RPL36AP21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.05427895
2cytidine metabolic process (GO:0046087)7.82194750
3cytidine catabolic process (GO:0006216)7.82194750
4cytidine deamination (GO:0009972)7.82194750
5pyrimidine ribonucleoside catabolic process (GO:0046133)7.05111217
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.96874929
7maturation of SSU-rRNA (GO:0030490)5.88002779
8leukocyte aggregation (GO:0070486)5.56910727
9activation of MAPKKK activity (GO:0000185)5.55764945
10ribosomal small subunit assembly (GO:0000028)4.80429644
11chaperone-mediated protein transport (GO:0072321)4.64231225
12viral transcription (GO:0019083)4.61727879
13ATP synthesis coupled proton transport (GO:0015986)4.60681033
14energy coupled proton transport, down electrochemical gradient (GO:0015985)4.60681033
15translational termination (GO:0006415)4.40466861
16regulation of activation of Janus kinase activity (GO:0010533)4.39880281
17macrophage chemotaxis (GO:0048246)4.36315855
18positive regulation of defense response to virus by host (GO:0002230)4.36194417
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.30261630
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.27373069
21metallo-sulfur cluster assembly (GO:0031163)4.21145042
22iron-sulfur cluster assembly (GO:0016226)4.21145042
23negative regulation by host of viral transcription (GO:0043922)4.21100019
24positive regulation of monocyte chemotaxis (GO:0090026)4.20003622
25ribosomal small subunit biogenesis (GO:0042274)4.01973799
26translational elongation (GO:0006414)3.97459653
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87779358
28protein targeting to ER (GO:0045047)3.85888469
29cotranslational protein targeting to membrane (GO:0006613)3.85658759
30eosinophil chemotaxis (GO:0048245)3.81751613
31respiratory electron transport chain (GO:0022904)3.71213636
32regulation of chronic inflammatory response (GO:0002676)3.69796844
33protein localization to endoplasmic reticulum (GO:0070972)3.67738355
34electron transport chain (GO:0022900)3.66882805
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.63271252
36pyrimidine nucleoside catabolic process (GO:0046135)3.61321200
37sequestering of actin monomers (GO:0042989)3.55330401
38positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.55063245
39eosinophil migration (GO:0072677)3.48204051
40positive regulation of natural killer cell mediated immunity (GO:0002717)3.45325042
41regulation of regulatory T cell differentiation (GO:0045589)3.45237451
42positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)3.45038228
43behavioral response to nicotine (GO:0035095)3.39685977
44positive T cell selection (GO:0043368)3.39092543
45positive regulation of interleukin-8 secretion (GO:2000484)3.35651019
46positive regulation of T cell apoptotic process (GO:0070234)3.33032778
47protein neddylation (GO:0045116)3.32298408
48cellular protein complex disassembly (GO:0043624)3.26053532
49viral life cycle (GO:0019058)3.25559379
50cellular response to interleukin-15 (GO:0071350)3.18829796
51cytolysis (GO:0019835)3.17757172
52glycoprotein catabolic process (GO:0006516)3.17662593
53positive thymic T cell selection (GO:0045059)3.15580865
54positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.13412776
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.09231942
56nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.08744217
57regulation of natural killer cell mediated immunity (GO:0002715)3.03438755
58regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.03438755
59negative regulation of viral genome replication (GO:0045071)3.02613865
60negative regulation of T cell apoptotic process (GO:0070233)2.99591960
61antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96286308
62Arp2/3 complex-mediated actin nucleation (GO:0034314)2.93409897
63male meiosis I (GO:0007141)2.91635985
64protein complex biogenesis (GO:0070271)2.90859144
65rRNA transcription (GO:0009303)2.89669417
66lymphocyte chemotaxis (GO:0048247)2.89110045
67regulation of interleukin-8 secretion (GO:2000482)2.85516049
68positive regulation of calcium-mediated signaling (GO:0050850)2.84524895
69positive regulation of translational initiation (GO:0045948)2.84032525
70establishment of protein localization to mitochondrial membrane (GO:0090151)2.83042394
71T cell migration (GO:0072678)2.76884692
72positive regulation of cell killing (GO:0031343)2.75907626
73translation (GO:0006412)2.74975208
74translational initiation (GO:0006413)2.73912760
75actin nucleation (GO:0045010)2.72084363
76antigen processing and presentation of endogenous antigen (GO:0019883)2.71303742
77regulation of leukocyte mediated cytotoxicity (GO:0001910)2.71301227
78pyrimidine-containing compound catabolic process (GO:0072529)2.68938466
79mitochondrial respiratory chain complex I assembly (GO:0032981)2.67229663
80NADH dehydrogenase complex assembly (GO:0010257)2.67229663
81mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67229663
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.66838927
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.66285862
84positive regulation of signal transduction by p53 class mediator (GO:1901798)2.65863978
85regulation of B cell receptor signaling pathway (GO:0050855)2.64921286
86regulation of lymphocyte chemotaxis (GO:1901623)2.64365673
87endoderm formation (GO:0001706)2.60103931
88detection of light stimulus involved in visual perception (GO:0050908)2.60054790
89detection of light stimulus involved in sensory perception (GO:0050962)2.60054790
90protein complex disassembly (GO:0043241)2.59452888
91response to interferon-beta (GO:0035456)2.59163665
92positive regulation of T cell mediated cytotoxicity (GO:0001916)2.58618493
93hydrogen ion transmembrane transport (GO:1902600)2.57695106
94regulation of lymphocyte migration (GO:2000401)2.56794273
95antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.56267530
96ncRNA 3-end processing (GO:0043628)2.55719936
97transmission of nerve impulse (GO:0019226)2.55506737
98proton transport (GO:0015992)2.54000398
99positive regulation of T cell chemotaxis (GO:0010820)2.53918835
100regulation of T cell chemotaxis (GO:0010819)2.53918835

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.30572533
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32634398
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24222008
4EZH2_22144423_ChIP-Seq_EOC_Human3.11979151
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.90666266
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.71922034
7VDR_22108803_ChIP-Seq_LS180_Human2.48054161
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.47661417
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47050140
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.26816787
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.16835944
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.07043502
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01995676
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.00239435
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87619441
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84999525
17LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.82852733
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.79585414
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77591790
20TP53_22573176_ChIP-Seq_HFKS_Human1.77042069
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75516063
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.72966208
23ZNF274_21170338_ChIP-Seq_K562_Hela1.65575934
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.64256596
25TAF2_19829295_ChIP-Seq_ESCs_Human1.61695775
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59745697
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.59357572
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.51927893
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49995730
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46169827
31VDR_23849224_ChIP-Seq_CD4+_Human1.46087963
32RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.41051970
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40313746
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.40021410
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.39224553
36AR_20517297_ChIP-Seq_VCAP_Human1.36885862
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.35440336
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.35196582
39SRF_21415370_ChIP-Seq_HL-1_Mouse1.33937536
40MYB_26560356_Chip-Seq_TH2_Human1.32854799
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.32417353
42NANOG_20526341_ChIP-Seq_ESCs_Human1.31515513
43STAT1_20625510_ChIP-Seq_HELA_Human1.30807583
44YY1_22570637_ChIP-Seq_MALME-3M_Human1.30667959
45ERA_21632823_ChIP-Seq_H3396_Human1.30599397
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30558919
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29686808
48PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.29384323
49JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29221712
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.28489593
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.27744325
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.27724047
53NCOR_22424771_ChIP-Seq_293T_Human1.27444239
54JARID2_20075857_ChIP-Seq_MESCs_Mouse1.26952688
55SA1_27219007_Chip-Seq_Bcells_Human1.26844524
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26289999
57CTCF_20526341_ChIP-Seq_ESCs_Human1.24821075
58GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.24095742
59FOXP3_21729870_ChIP-Seq_TREG_Human1.23264698
60E2F1_20622854_ChIP-Seq_HELA_Human1.19471226
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19334715
62GATA6_21074721_ChIP-Seq_CACO-2_Human1.18669767
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18200256
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18065627
65BCL6_27268052_Chip-Seq_Bcells_Human1.16622136
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16230226
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.15713615
68MYC_18940864_ChIP-ChIP_HL60_Human1.15576392
69SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15507444
70CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14576562
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12796447
72EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11226487
73IRF8_21731497_ChIP-ChIP_J774_Mouse1.09205826
74RUNX_20019798_ChIP-Seq_JUKART_Human1.08212665
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.06314087
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06314087
77POU5F1_16153702_ChIP-ChIP_HESCs_Human1.06144102
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05821880
79MAF_26560356_Chip-Seq_TH2_Human1.05702445
80GATA3_27048872_Chip-Seq_THYMUS_Human1.05085749
81GATA3_26560356_Chip-Seq_TH2_Human1.04352395
82MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02846286
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02427174
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.02315047
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01797268
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.01772311
87HTT_18923047_ChIP-ChIP_STHdh_Human1.01436398
88P53_21459846_ChIP-Seq_SAOS-2_Human0.99825354
89MYC_19829295_ChIP-Seq_ESCs_Human0.99117101
90RBPJ_21746931_ChIP-Seq_IB4_Human0.98897027
91RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98202521
92ERG_20517297_ChIP-Seq_VCAP_Human0.95828602
93VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95573445
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95154878
95SOX2_21211035_ChIP-Seq_LN229_Human0.94878808
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94723136
97PHF8_20622853_ChIP-Seq_HELA_Human0.94151840
98CIITA_25753668_ChIP-Seq_RAJI_Human0.93762830
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93058679
100CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92599748

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.98587158
2MP0005623_abnormal_meninges_morphology4.59883969
3MP0001348_abnormal_lacrimal_gland4.14216852
4MP0009379_abnormal_foot_pigmentation3.13653830
5MP0005377_hearing/vestibular/ear_phenot2.95853975
6MP0003878_abnormal_ear_physiology2.95853975
7MP0001835_abnormal_antigen_presentation2.46017621
8MP0004147_increased_porphyrin_level2.27380725
9MP0000372_irregular_coat_pigmentation2.09199808
10MP0002163_abnormal_gland_morphology2.05327179
11MP0003136_yellow_coat_color1.99204373
12MP0003786_premature_aging1.96994702
13MP0002638_abnormal_pupillary_reflex1.93069792
14MP0003011_delayed_dark_adaptation1.89210296
15MP0002138_abnormal_hepatobiliary_system1.89026363
16MP0009785_altered_susceptibility_to1.88676278
17MP0006292_abnormal_olfactory_placode1.88385767
18MP0005551_abnormal_eye_electrophysiolog1.79832390
19MP0000750_abnormal_muscle_regeneration1.79515896
20MP0001800_abnormal_humoral_immune1.73850294
21MP0005379_endocrine/exocrine_gland_phen1.70463448
22MP0001790_abnormal_immune_system1.65503230
23MP0005387_immune_system_phenotype1.65503230
24MP0001873_stomach_inflammation1.65338172
25MP0009333_abnormal_splenocyte_physiolog1.59519534
26MP0002277_abnormal_respiratory_mucosa1.58841924
27MP0002102_abnormal_ear_morphology1.58264760
28MP0004885_abnormal_endolymph1.54851629
29MP0003763_abnormal_thymus_physiology1.51316206
30MP0003646_muscle_fatigue1.45021698
31MP0001188_hyperpigmentation1.44418917
32MP0008872_abnormal_physiological_respon1.44381942
33MP0004145_abnormal_muscle_electrophysio1.43738785
34MP0002420_abnormal_adaptive_immunity1.42659088
35MP0002723_abnormal_immune_serum1.41413898
36MP0006082_CNS_inflammation1.39680938
37MP0001485_abnormal_pinna_reflex1.38824960
38MP0002938_white_spotting1.37556529
39MP0000685_abnormal_immune_system1.37504413
40MP0009384_cardiac_valve_regurgitation1.37390902
41MP0005025_abnormal_response_to1.37058156
42MP0001819_abnormal_immune_cell1.36463306
43MP0003866_abnormal_defecation1.31086969
44MP0001905_abnormal_dopamine_level1.29008083
45MP0005000_abnormal_immune_tolerance1.26890055
46MP0002095_abnormal_skin_pigmentation1.25985445
47MP0003137_abnormal_impulse_conducting1.25948295
48MP0003567_abnormal_fetal_cardiomyocyte1.24980280
49MP0006276_abnormal_autonomic_nervous1.24010750
50MP0003195_calcinosis1.18566207
51MP0002148_abnormal_hypersensitivity_rea1.17708379
52MP0004742_abnormal_vestibular_system1.17035424
53MP0004142_abnormal_muscle_tone1.16217555
54MP0000858_altered_metastatic_potential1.14743666
55MP0005389_reproductive_system_phenotype1.14729482
56MP0002933_joint_inflammation1.11769472
57MP0002160_abnormal_reproductive_system1.10458490
58MP0002452_abnormal_antigen_presenting1.09215139
59MP0004130_abnormal_muscle_cell1.03352081
60MP0005645_abnormal_hypothalamus_physiol1.02775051
61MP0010155_abnormal_intestine_physiology1.02091360
62MP0009745_abnormal_behavioral_response0.99660323
63MP0006072_abnormal_retinal_apoptosis0.98982954
64MP0002837_dystrophic_cardiac_calcinosis0.92451143
65MP0005253_abnormal_eye_physiology0.92273619
66MP0005083_abnormal_biliary_tract0.92011712
67MP0001919_abnormal_reproductive_system0.91218435
68MP0000716_abnormal_immune_system0.91187921
69MP0008875_abnormal_xenobiotic_pharmacok0.90153457
70MP0002067_abnormal_sensory_capabilities0.88375313
71MP0009764_decreased_sensitivity_to0.86902346
72MP0003880_abnormal_central_pattern0.86600863
73MP0008877_abnormal_DNA_methylation0.85755154
74MP0002736_abnormal_nociception_after0.83086043
75MP0000013_abnormal_adipose_tissue0.82739183
76MP0002876_abnormal_thyroid_physiology0.81168059
77MP0005646_abnormal_pituitary_gland0.79689329
78MP0001968_abnormal_touch/_nociception0.78756527
79MP0005410_abnormal_fertilization0.78346391
80MP0000689_abnormal_spleen_morphology0.77450256
81MP0003879_abnormal_hair_cell0.76932934
82MP0001970_abnormal_pain_threshold0.76579226
83MP0000762_abnormal_tongue_morphology0.76396089
84MP0005584_abnormal_enzyme/coenzyme_acti0.75778790
85MP0002733_abnormal_thermal_nociception0.75496552
86MP0005195_abnormal_posterior_eye0.72530885
87MP0001293_anophthalmia0.72257874
88MP0002722_abnormal_immune_system0.72256406
89MP0001845_abnormal_inflammatory_respons0.72256008
90MP0002405_respiratory_system_inflammati0.72138813
91MP0001529_abnormal_vocalization0.71980795
92MP0002272_abnormal_nervous_system0.71479907
93MP0010307_abnormal_tumor_latency0.71468588
94MP0002177_abnormal_outer_ear0.71275381
95MP0003936_abnormal_reproductive_system0.70437551
96MP0002398_abnormal_bone_marrow0.70313305
97MP0001986_abnormal_taste_sensitivity0.70295096
98MP0009765_abnormal_xenobiotic_induced0.70173980
99MP0005636_abnormal_mineral_homeostasis0.68568250
100MP0002653_abnormal_ependyma_morphology0.68551485

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)6.17201709
2Retinal atrophy (HP:0001105)6.16242377
3Cerebellar dysplasia (HP:0007033)6.10790343
4Retinal dysplasia (HP:0007973)5.86571443
5Decreased electroretinogram (ERG) amplitude (HP:0000654)5.23628908
6Hypoplasia of the pons (HP:0012110)5.21295726
7Abnormality of the pons (HP:0007361)4.87009766
8Abolished electroretinogram (ERG) (HP:0000550)4.43317468
9IgG deficiency (HP:0004315)4.03141380
10Aplasia/Hypoplasia affecting the retina (HP:0008061)3.95865305
11Increased IgM level (HP:0003496)3.86292813
12Acute necrotizing encephalopathy (HP:0006965)3.43216073
13Fatigue (HP:0012378)3.28321331
14Abnormality of T cell number (HP:0011839)3.28015841
15T lymphocytopenia (HP:0005403)3.27099338
16Abnormal mitochondria in muscle tissue (HP:0008316)3.09169994
17Mitochondrial inheritance (HP:0001427)3.09142846
18Congenital stationary night blindness (HP:0007642)3.06755866
19Severe muscular hypotonia (HP:0006829)2.88325957
20Recurrent bronchitis (HP:0002837)2.87195571
21Molar tooth sign on MRI (HP:0002419)2.86801801
22Abnormality of midbrain morphology (HP:0002418)2.86801801
23Elevated erythrocyte sedimentation rate (HP:0003565)2.80535769
24Difficulty climbing stairs (HP:0003551)2.80531869
253-Methylglutaconic aciduria (HP:0003535)2.73886938
26Progressive macrocephaly (HP:0004481)2.73433308
27Buphthalmos (HP:0000557)2.72930081
28Acute encephalopathy (HP:0006846)2.72173776
29Aplastic anemia (HP:0001915)2.69976944
30Hypoalbuminemia (HP:0003073)2.64477149
31Abnormal albumin level (HP:0012116)2.64477149
32Pallor (HP:0000980)2.64305359
33Increased CSF lactate (HP:0002490)2.62825441
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.61085500
35Abnormality of DNA repair (HP:0003254)2.59663451
36Decreased activity of mitochondrial respiratory chain (HP:0008972)2.53811927
37Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.53811927
38Hepatocellular necrosis (HP:0001404)2.49663551
39Entropion (HP:0000621)2.44632911
40Pancreatic fibrosis (HP:0100732)2.41958362
41Pancreatic cysts (HP:0001737)2.40147082
42Hypoproteinemia (HP:0003075)2.36906905
43Abnormal rod and cone electroretinograms (HP:0008323)2.33866371
44Colon cancer (HP:0003003)2.31762523
45Medial flaring of the eyebrow (HP:0010747)2.31714765
46Abnormality of eosinophils (HP:0001879)2.23320125
47Chronic otitis media (HP:0000389)2.23287908
48Increased intramyocellular lipid droplets (HP:0012240)2.22181747
49Abnormality of T cells (HP:0002843)2.19720105
50Chronic sinusitis (HP:0011109)2.15355772
51Eosinophilia (HP:0001880)2.15338526
52True hermaphroditism (HP:0010459)2.15008442
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.14637666
54Nasal polyposis (HP:0100582)2.09924653
55Cerebral edema (HP:0002181)2.09617952
56Lissencephaly (HP:0001339)2.09173377
57Lipid accumulation in hepatocytes (HP:0006561)2.09061781
58Hepatic necrosis (HP:0002605)2.08912519
59Sclerocornea (HP:0000647)2.07987171
60Bronchitis (HP:0012387)2.07680650
61Chronic hepatic failure (HP:0100626)2.05797550
62Reticulocytopenia (HP:0001896)2.05420286
63Increased muscle lipid content (HP:0009058)2.01631112
64Rectal prolapse (HP:0002035)1.96536976
65Generalized muscle weakness (HP:0003324)1.96263610
66Decreased central vision (HP:0007663)1.95917465
67Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.95751524
68Nephronophthisis (HP:0000090)1.95673963
69Abnormality of cells of the erythroid lineage (HP:0012130)1.95552344
70Increased hepatocellular lipid droplets (HP:0006565)1.94160372
71Abnormal drinking behavior (HP:0030082)1.90848109
72Polydipsia (HP:0001959)1.90848109
73Severe visual impairment (HP:0001141)1.89409733
74Erythroderma (HP:0001019)1.86593482
75Aplasia/Hypoplasia of the brainstem (HP:0007362)1.83311585
76Hypoplasia of the brainstem (HP:0002365)1.83311585
77Renal Fanconi syndrome (HP:0001994)1.81232797
78Hypothermia (HP:0002045)1.81201926
79Cellular immunodeficiency (HP:0005374)1.80360675
80Optic disc pallor (HP:0000543)1.79697760
81Leukocytosis (HP:0001974)1.78970716
82Pachygyria (HP:0001302)1.77209445
83Abnormality of the heme biosynthetic pathway (HP:0010472)1.76566590
84Type 2 muscle fiber atrophy (HP:0003554)1.76177045
85Lethargy (HP:0001254)1.74953429
86Obstructive lung disease (HP:0006536)1.73526495
87Chronic obstructive pulmonary disease (HP:0006510)1.73526495
88Methylmalonic acidemia (HP:0002912)1.70971714
89Abnormality of magnesium homeostasis (HP:0004921)1.70883940
90Encephalitis (HP:0002383)1.70801562
91Poikiloderma (HP:0001029)1.70666707
92Abnormality of the nasal mucosa (HP:0000433)1.70034325
93Megalocornea (HP:0000485)1.69852523
94Abnormal number of erythroid precursors (HP:0012131)1.66897646
95Keratitis (HP:0000491)1.65304108
96Gastrointestinal infarctions (HP:0005244)1.64374947
97Methylmalonic aciduria (HP:0012120)1.64052202
98Abnormality of the vitreous humor (HP:0004327)1.63037071
99Rib fusion (HP:0000902)1.62279455
100Polyuria (HP:0000103)1.61380197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.51656390
2MAP3K134.33725666
3KDR3.67142388
4MARK33.41776097
5STK103.14547600
6TESK23.07936355
7BCKDK2.97739328
8TAOK32.96150982
9STK162.67685827
10WNK42.64532584
11ADRBK22.37699423
12MAP3K92.29714204
13MAP4K12.20139429
14ARAF2.19221119
15TLK11.86780078
16GRK11.84246782
17PINK11.76456227
18ITK1.53839530
19PIM11.50322207
20PRKCQ1.33410503
21PDK21.23354392
22STK111.23208969
23MAP3K111.19164265
24MUSK1.14408380
25TIE11.08539189
26PTK2B1.01660407
27MAP4K20.99903801
28FRK0.96492197
29BRAF0.94001866
30SYK0.93719376
31GRK70.91232995
32LCK0.91147587
33MAP2K70.88162840
34BMPR1B0.86488646
35LIMK10.85623814
36PRKCH0.83802645
37TNK20.81555483
38CAMKK20.78225468
39STK390.74761278
40FES0.74442375
41TEC0.73516161
42ILK0.73406436
43BTK0.73009093
44MOS0.72819142
45PASK0.71797285
46PIK3CA0.71493046
47ZAK0.67605844
48CSK0.65138333
49DYRK20.64301244
50IKBKB0.63980887
51INSRR0.62968996
52RPS6KA50.61475317
53MAPK150.60674174
54LMTK20.57910173
55NTRK20.56929421
56GRK60.56633421
57CLK10.55355939
58CAMKK10.54584199
59OBSCN0.53788967
60MAPKAPK30.53381844
61NUAK10.51546685
62VRK20.50725767
63VRK10.49404895
64MAPK130.48708598
65FYN0.46654075
66AURKA0.46402858
67CAMK10.45773536
68PRKACA0.44536763
69LYN0.43792839
70OXSR10.43005749
71MYLK0.40280727
72PLK40.39664266
73PRKCA0.39053439
74IGF1R0.38674544
75MATK0.38647756
76PRKCG0.38379674
77WNK30.37869600
78CSNK1A10.36197328
79NME10.36046203
80TYRO30.34435069
81ADRBK10.34351370
82NLK0.33910224
83CDK190.33213512
84PIK3CG0.31909520
85CSNK2A20.31780370
86CAMK2A0.30502956
87NTRK10.29456363
88RAF10.27053637
89ZAP700.26556221
90MAP3K120.26156848
91MAP3K40.26039246
92CSNK2A10.25834767
93MAP2K60.25084206
94CSF1R0.24234612
95INSR0.23408159
96PRKCD0.22803458
97ROCK10.22751245
98SGK10.20919856
99PIM20.18982723
100BRSK20.18508810

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.41256925
2Oxidative phosphorylation_Homo sapiens_hsa001904.01397497
3Primary immunodeficiency_Homo sapiens_hsa053403.99032242
4Proteasome_Homo sapiens_hsa030503.43087312
5Parkinsons disease_Homo sapiens_hsa050123.30364043
6Graft-versus-host disease_Homo sapiens_hsa053322.59375563
7Autoimmune thyroid disease_Homo sapiens_hsa053202.58042949
8Antigen processing and presentation_Homo sapiens_hsa046122.48368988
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.41311825
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35439626
11Allograft rejection_Homo sapiens_hsa053302.34129501
12Alzheimers disease_Homo sapiens_hsa050102.20105227
13Huntingtons disease_Homo sapiens_hsa050162.11696503
14Cardiac muscle contraction_Homo sapiens_hsa042602.11582774
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.09800323
16RNA polymerase_Homo sapiens_hsa030201.95146893
17Linoleic acid metabolism_Homo sapiens_hsa005911.79906271
18Protein export_Homo sapiens_hsa030601.79542278
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.75628005
20Hematopoietic cell lineage_Homo sapiens_hsa046401.74977601
21T cell receptor signaling pathway_Homo sapiens_hsa046601.64716333
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63275789
23Type I diabetes mellitus_Homo sapiens_hsa049401.60167856
24NF-kappa B signaling pathway_Homo sapiens_hsa040641.57715322
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46324693
26Rheumatoid arthritis_Homo sapiens_hsa053231.45227895
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.42893363
28Phototransduction_Homo sapiens_hsa047441.39649681
29Homologous recombination_Homo sapiens_hsa034401.37988384
30Asthma_Homo sapiens_hsa053101.37693917
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.33946912
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.29256940
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.28957644
34Nitrogen metabolism_Homo sapiens_hsa009101.24220539
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20155478
36Caffeine metabolism_Homo sapiens_hsa002321.07671557
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.04108605
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02357753
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01499000
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99733911
41Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97599308
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.96808813
43Sulfur relay system_Homo sapiens_hsa041220.91683117
44Ether lipid metabolism_Homo sapiens_hsa005650.86698695
45Collecting duct acid secretion_Homo sapiens_hsa049660.81424626
46Pyrimidine metabolism_Homo sapiens_hsa002400.78959169
47Regulation of autophagy_Homo sapiens_hsa041400.75139959
48Olfactory transduction_Homo sapiens_hsa047400.74468749
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72743209
50Malaria_Homo sapiens_hsa051440.67452236
51Basal transcription factors_Homo sapiens_hsa030220.64512858
52Nicotine addiction_Homo sapiens_hsa050330.63509278
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.61528623
54Retinol metabolism_Homo sapiens_hsa008300.60580429
55Nucleotide excision repair_Homo sapiens_hsa034200.60303809
56Peroxisome_Homo sapiens_hsa041460.58728639
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58702449
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.57565163
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54818599
60Arachidonic acid metabolism_Homo sapiens_hsa005900.53506600
61Purine metabolism_Homo sapiens_hsa002300.49469045
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.47706728
63Viral myocarditis_Homo sapiens_hsa054160.47265717
64TNF signaling pathway_Homo sapiens_hsa046680.47217843
65Butanoate metabolism_Homo sapiens_hsa006500.45552290
66Chemical carcinogenesis_Homo sapiens_hsa052040.45493423
67RNA degradation_Homo sapiens_hsa030180.43590404
68Metabolic pathways_Homo sapiens_hsa011000.43502728
69Chemokine signaling pathway_Homo sapiens_hsa040620.43019007
70Measles_Homo sapiens_hsa051620.42356156
71Salmonella infection_Homo sapiens_hsa051320.41060729
72Insulin secretion_Homo sapiens_hsa049110.40788076
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.39311195
74Propanoate metabolism_Homo sapiens_hsa006400.37833674
75Systemic lupus erythematosus_Homo sapiens_hsa053220.36643610
76Fatty acid degradation_Homo sapiens_hsa000710.36205689
77Fat digestion and absorption_Homo sapiens_hsa049750.34649926
78Fatty acid metabolism_Homo sapiens_hsa012120.33754177
79Fanconi anemia pathway_Homo sapiens_hsa034600.32961912
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.32824133
81Mineral absorption_Homo sapiens_hsa049780.32431312
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31757849
83Leishmaniasis_Homo sapiens_hsa051400.30318851
84Morphine addiction_Homo sapiens_hsa050320.29997554
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27982429
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26434523
87Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25870395
88One carbon pool by folate_Homo sapiens_hsa006700.24186340
89Apoptosis_Homo sapiens_hsa042100.23671135
90Epstein-Barr virus infection_Homo sapiens_hsa051690.21874095
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.18895610
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18544893
93Osteoclast differentiation_Homo sapiens_hsa043800.18367282
94Prion diseases_Homo sapiens_hsa050200.18323705
95Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18106354
96Sulfur metabolism_Homo sapiens_hsa009200.17815343
97RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16792507
98MAPK signaling pathway_Homo sapiens_hsa040100.16615894
99Serotonergic synapse_Homo sapiens_hsa047260.16594913
100Ovarian steroidogenesis_Homo sapiens_hsa049130.16320987

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