ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.87617490
2	viral transcription (GO:0019083)	9.63961919
3	translational termination (GO:0006415)	9.19213175
4	ribosomal small subunit assembly (GO:0000028)	8.80973775
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.77976508
6	cotranslational protein targeting to membrane (GO:0006613)	7.67329571
7	translational elongation (GO:0006414)	7.66117638
8	maturation of SSU-rRNA (GO:0030490)	7.62392110
9	protein targeting to ER (GO:0045047)	7.61505396
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.32117066
11	protein localization to endoplasmic reticulum (GO:0070972)	7.15217077
12	cellular protein complex disassembly (GO:0043624)	7.05417492
13	viral life cycle (GO:0019058)	6.90316747
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.83908341
15	translational initiation (GO:0006413)	6.20172558
16	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.09001756
17	ATP synthesis coupled proton transport (GO:0015986)	6.09001756
18	protein complex disassembly (GO:0043241)	6.00703763
19	macromolecular complex disassembly (GO:0032984)	5.64295388
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.57452867
21	chaperone-mediated protein transport (GO:0072321)	5.44114956
22	ribosomal large subunit biogenesis (GO:0042273)	5.32733221
23	protein targeting to membrane (GO:0006612)	5.22422958
24	translation (GO:0006412)	5.08838780
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.85997870
26	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.84293719
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.83807889
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.83807889
29	NADH dehydrogenase complex assembly (GO:0010257)	4.83807889
30	protein neddylation (GO:0045116)	4.69660335
31	ribonucleoprotein complex biogenesis (GO:0022613)	4.62407523
32	mRNA catabolic process (GO:0006402)	4.58221678
33	substrate-independent telencephalic tangential migration (GO:0021826)	4.54819919
34	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.54819919
35	respiratory electron transport chain (GO:0022904)	4.44565686
36	protein complex biogenesis (GO:0070271)	4.42869638
37	electron transport chain (GO:0022900)	4.39405195
38	cellular component biogenesis (GO:0044085)	4.33792315
39	behavioral response to nicotine (GO:0035095)	4.18896645
40	RNA catabolic process (GO:0006401)	4.16213369
41	mitochondrial respiratory chain complex assembly (GO:0033108)	4.12173468
42	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.81077718
43	peptidyl-histidine modification (GO:0018202)	3.72782324
44	rRNA processing (GO:0006364)	3.70762843
45	DNA deamination (GO:0045006)	3.70474648
46	negative regulation of mast cell activation (GO:0033004)	3.68146238
47	rRNA metabolic process (GO:0016072)	3.62526554
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.59520914
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.56660127
50	ncRNA 3-end processing (GO:0043628)	3.54601632
51	ATP biosynthetic process (GO:0006754)	3.53787085
52	establishment of protein localization to membrane (GO:0090150)	3.52385272
53	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.47532560
54	protein targeting (GO:0006605)	3.47416417
55	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.40926337
56	nonmotile primary cilium assembly (GO:0035058)	3.37521151
57	GTP biosynthetic process (GO:0006183)	3.27726564
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.26493375
59	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.23247840
60	establishment of protein localization to organelle (GO:0072594)	3.23219032
61	termination of RNA polymerase III transcription (GO:0006386)	3.22276135
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.22276135
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.18118373
64	pyrimidine nucleotide catabolic process (GO:0006244)	3.10991913
65	water-soluble vitamin biosynthetic process (GO:0042364)	3.09229832
66	hydrogen ion transmembrane transport (GO:1902600)	3.08022628
67	protein targeting to mitochondrion (GO:0006626)	3.03023727
68	UTP biosynthetic process (GO:0006228)	3.02307577
69	regulation of mitochondrial translation (GO:0070129)	3.00504709
70	axonemal dynein complex assembly (GO:0070286)	2.99325570
71	cell proliferation in forebrain (GO:0021846)	2.98974789
72	pseudouridine synthesis (GO:0001522)	2.95498773
73	regulation of activation of Janus kinase activity (GO:0010533)	2.92868890
74	myoblast migration (GO:0051451)	2.91428176
75	ubiquinone biosynthetic process (GO:0006744)	2.84460510
76	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.84432981
77	establishment of protein localization to mitochondrion (GO:0072655)	2.82890554
78	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81609871
79	somite development (GO:0061053)	2.81363490
80	protein localization to membrane (GO:0072657)	2.80807520
81	respiratory chain complex IV assembly (GO:0008535)	2.80784008
82	nucleoside triphosphate biosynthetic process (GO:0009142)	2.78588812
83	epithelial cilium movement (GO:0003351)	2.76873106
84	UTP metabolic process (GO:0046051)	2.76374064
85	response to redox state (GO:0051775)	2.73228582
86	positive regulation of respiratory burst (GO:0060267)	2.72201179
87	iron-sulfur cluster assembly (GO:0016226)	2.70889641
88	metallo-sulfur cluster assembly (GO:0031163)	2.70889641
89	motile cilium assembly (GO:0044458)	2.68299915
90	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.67255373
91	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.67255373
92	cardiovascular system development (GO:0072358)	2.66989247
93	proton transport (GO:0015992)	2.66413887
94	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.66184829
95	ncRNA processing (GO:0034470)	2.63502038
96	cytochrome complex assembly (GO:0017004)	2.62679265
97	protein localization to mitochondrion (GO:0070585)	2.60824129
98	hydrogen transport (GO:0006818)	2.59562798
99	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.58904124
100	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.58401547

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.31440944
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.96155276
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.64113840
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.60881492
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.52880709
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.43851110
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.15884442
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.14129788
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.88295898
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.84030357
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.68337569
12	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.64323701
13	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.31375804
14	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.29619359
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25614112
16	TTF2_22483619_ChIP-Seq_HELA_Human	2.21687434
17	XRN2_22483619_ChIP-Seq_HELA_Human	2.20374322
18	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.19495416
19	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.10191825
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.04450244
21	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.87120330
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.82502395
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.80438023
24	VDR_23849224_ChIP-Seq_CD4+_Human	1.78384945
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.74413709
26	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.73512052
27	GABP_19822575_ChIP-Seq_HepG2_Human	1.66785281
28	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.65701209
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.65092460
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.63582332
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.63497980
32	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.62780808
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.61191852
34	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.60311895
35	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.52009387
36	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.51116801
37	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.45632019
38	VDR_22108803_ChIP-Seq_LS180_Human	1.44079762
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.42380870
40	ZNF274_21170338_ChIP-Seq_K562_Hela	1.41325716
41	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.40507908
42	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40133238
43	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.36167450
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35601842
45	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.35270234
46	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.33666108
47	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.30105528
48	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.29144284
49	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.27916750
50	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26794215
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25327218
52	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.24263724
53	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.22083738
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.19723572
55	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.19444111
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.17032883
57	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.16414504
58	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.16273114
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.15878466
60	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.15739264
61	NCOR_22424771_ChIP-Seq_293T_Human	1.14717337
62	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.12845415
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.10473214
64	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.09846984
65	EWS_26573619_Chip-Seq_HEK293_Human	1.07953388
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07627756
67	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07476070
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.07463551
69	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.06887762
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.05699990
71	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05406463
72	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.04941069
73	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.04349034
74	ERA_21632823_ChIP-Seq_H3396_Human	1.04252281
75	NANOG_20526341_ChIP-Seq_ESCs_Human	1.04083626
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03330552
77	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.02816921
78	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.02423850
79	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.99764789
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99368640
81	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.99133618
82	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.98258678
83	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.96535738
84	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96157043
85	CTCF_27219007_Chip-Seq_Bcells_Human	0.96065935
86	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.94189076
87	RNF2_27304074_Chip-Seq_NSC_Mouse	0.93888906
88	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.93707065
89	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92980598
90	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90818949
91	REST_21632747_ChIP-Seq_MESCs_Mouse	0.90669087
92	BCL6_27268052_Chip-Seq_Bcells_Human	0.90309862
93	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.89503655
94	CTCF_26484167_Chip-Seq_Bcells_Mouse	0.87989373
95	KDM5A_27292631_Chip-Seq_BREAST_Human	0.86548081
96	P53_21459846_ChIP-Seq_SAOS-2_Human	0.86379192
97	P68_20966046_ChIP-Seq_HELA_Human	0.86080036
98	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.86065328
99	SA1_27219007_Chip-Seq_Bcells_Human	0.85781739
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.85234203

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.99342199
2	MP0006292_abnormal_olfactory_placode	5.81838576
3	MP0003787_abnormal_imprinting	2.63761590
4	MP0003122_maternal_imprinting	2.62460831
5	MP0003123_paternal_imprinting	2.47358738
6	MP0002163_abnormal_gland_morphology	2.44157950
7	MP0008789_abnormal_olfactory_epithelium	2.20020758
8	MP0003646_muscle_fatigue	2.18234047
9	MP0008877_abnormal_DNA_methylation	2.15688655
10	MP0000049_abnormal_middle_ear	2.08951618
11	MP0003878_abnormal_ear_physiology	1.98115357
12	MP0005377_hearing/vestibular/ear_phenot	1.98115357
13	MP0001293_anophthalmia	1.97480190
14	MP0005646_abnormal_pituitary_gland	1.95546987
15	MP0005394_taste/olfaction_phenotype	1.90314698
16	MP0005499_abnormal_olfactory_system	1.90314698
17	MP0003121_genomic_imprinting	1.88087117
18	MP0004142_abnormal_muscle_tone	1.87858852
19	MP0002653_abnormal_ependyma_morphology	1.78136886
20	MP0005174_abnormal_tail_pigmentation	1.64910971
21	MP0001188_hyperpigmentation	1.58355556
22	MP0002938_white_spotting	1.54696876
23	MP0004885_abnormal_endolymph	1.54561337
24	MP0006072_abnormal_retinal_apoptosis	1.54247162
25	MP0001348_abnormal_lacrimal_gland	1.46949381
26	MP0004133_heterotaxia	1.45400316
27	MP0001529_abnormal_vocalization	1.41712247
28	MP0002160_abnormal_reproductive_system	1.38005060
29	MP0005379_endocrine/exocrine_gland_phen	1.36121945
30	MP0002095_abnormal_skin_pigmentation	1.35013529
31	MP0001968_abnormal_touch/_nociception	1.31080714
32	MP0002736_abnormal_nociception_after	1.30981227
33	MP0005389_reproductive_system_phenotype	1.27003407
34	MP0005551_abnormal_eye_electrophysiolog	1.26744168
35	MP0010030_abnormal_orbit_morphology	1.24754033
36	MP0006276_abnormal_autonomic_nervous	1.24444039
37	MP0005084_abnormal_gallbladder_morpholo	1.23173315
38	MP0000631_abnormal_neuroendocrine_gland	1.21552153
39	MP0002277_abnormal_respiratory_mucosa	1.21119414
40	MP0001984_abnormal_olfaction	1.17637316
41	MP0004145_abnormal_muscle_electrophysio	1.17145875
42	MP0003938_abnormal_ear_development	1.16655974
43	MP0003186_abnormal_redox_activity	1.15799874
44	MP0008872_abnormal_physiological_respon	1.13649229
45	MP0002822_catalepsy	1.13153392
46	MP0002272_abnormal_nervous_system	1.12075162
47	MP0002233_abnormal_nose_morphology	1.10196350
48	MP0002876_abnormal_thyroid_physiology	1.09428882
49	MP0002638_abnormal_pupillary_reflex	1.09193199
50	MP0008875_abnormal_xenobiotic_pharmacok	1.07334061
51	MP0005195_abnormal_posterior_eye	1.06937560
52	MP0001919_abnormal_reproductive_system	1.06828415
53	MP0002102_abnormal_ear_morphology	1.05287930
54	MP0003315_abnormal_perineum_morphology	1.04256331
55	MP0003786_premature_aging	1.03746075
56	MP0003567_abnormal_fetal_cardiomyocyte	1.02782452
57	MP0003119_abnormal_digestive_system	1.02284635
58	MP0002234_abnormal_pharynx_morphology	1.00899395
59	MP0001485_abnormal_pinna_reflex	0.98383349
60	MP0010368_abnormal_lymphatic_system	0.96220949
61	MP0003136_yellow_coat_color	0.96126020
62	MP0003693_abnormal_embryo_hatching	0.96097542
63	MP0001986_abnormal_taste_sensitivity	0.94938850
64	MP0003937_abnormal_limbs/digits/tail_de	0.94161358
65	MP0006036_abnormal_mitochondrial_physio	0.93428126
66	MP0003011_delayed_dark_adaptation	0.92275817
67	MP0000678_abnormal_parathyroid_gland	0.92238347
68	MP0002249_abnormal_larynx_morphology	0.91813343
69	MP0002210_abnormal_sex_determination	0.91482395
70	MP0002837_dystrophic_cardiac_calcinosis	0.90702485
71	MP0003942_abnormal_urinary_system	0.90496156
72	MP0002752_abnormal_somatic_nervous	0.89558420
73	MP0002184_abnormal_innervation	0.89289196
74	MP0003880_abnormal_central_pattern	0.87396546
75	MP0009745_abnormal_behavioral_response	0.86398230
76	MP0002557_abnormal_social/conspecific_i	0.86315833
77	MP0004742_abnormal_vestibular_system	0.83692139
78	MP0000778_abnormal_nervous_system	0.83674442
79	MP0000015_abnormal_ear_pigmentation	0.83480458
80	MP0001440_abnormal_grooming_behavior	0.83404216
81	MP0005391_vision/eye_phenotype	0.80622254
82	MP0000026_abnormal_inner_ear	0.80497660
83	MP0001324_abnormal_eye_pigmentation	0.80219647
84	MP0001502_abnormal_circadian_rhythm	0.78301714
85	MP0002928_abnormal_bile_duct	0.77718194
86	MP0000955_abnormal_spinal_cord	0.75983661
87	MP0001286_abnormal_eye_development	0.75842802
88	MP0005645_abnormal_hypothalamus_physiol	0.75177973
89	MP0003755_abnormal_palate_morphology	0.73303672
90	MP0002733_abnormal_thermal_nociception	0.72402794
91	MP0001970_abnormal_pain_threshold	0.72103697
92	MP0009046_muscle_twitch	0.71331641
93	MP0003936_abnormal_reproductive_system	0.70239561
94	MP0002092_abnormal_eye_morphology	0.67383161
95	MP0004019_abnormal_vitamin_homeostasis	0.66126889
96	MP0003879_abnormal_hair_cell	0.65186572
97	MP0005253_abnormal_eye_physiology	0.65170503
98	MP0005423_abnormal_somatic_nervous	0.64962858
99	MP0000653_abnormal_sex_gland	0.64106481
100	MP0003718_maternal_effect	0.63478082

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.50837537
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.97738889
3	Acute necrotizing encephalopathy (HP:0006965)	4.78378001
4	Macrocytic anemia (HP:0001972)	4.52385355
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.26374184
6	3-Methylglutaconic aciduria (HP:0003535)	4.17294970
7	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.02949755
8	Abnormal number of erythroid precursors (HP:0012131)	4.01581875
9	Mitochondrial inheritance (HP:0001427)	3.99494133
10	Acute encephalopathy (HP:0006846)	3.99448352
11	Abnormality of midbrain morphology (HP:0002418)	3.87919391
12	Molar tooth sign on MRI (HP:0002419)	3.87919391
13	Progressive macrocephaly (HP:0004481)	3.78975295
14	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.67209822
15	Increased CSF lactate (HP:0002490)	3.65221822
16	Pallor (HP:0000980)	3.50653110
17	Increased hepatocellular lipid droplets (HP:0006565)	3.32655974
18	Lipid accumulation in hepatocytes (HP:0006561)	3.14384497
19	Pancreatic fibrosis (HP:0100732)	2.99433784
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.98040924
21	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.95566748
22	Cerebral edema (HP:0002181)	2.94380112
23	Pancreatic cysts (HP:0001737)	2.88281631
24	Renal Fanconi syndrome (HP:0001994)	2.84637032
25	Abnormal rod and cone electroretinograms (HP:0008323)	2.76848087
26	Hepatocellular necrosis (HP:0001404)	2.69743604
27	Type II lissencephaly (HP:0007260)	2.64719464
28	Stenosis of the external auditory canal (HP:0000402)	2.59581258
29	Absent/shortened dynein arms (HP:0200106)	2.59455851
30	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.59455851
31	Hepatic necrosis (HP:0002605)	2.58088945
32	Increased intramyocellular lipid droplets (HP:0012240)	2.57893161
33	Absent thumb (HP:0009777)	2.56322064
34	Pendular nystagmus (HP:0012043)	2.49313910
35	Septo-optic dysplasia (HP:0100842)	2.43718061
36	Colon cancer (HP:0003003)	2.43541573
37	Asplenia (HP:0001746)	2.42250449
38	Increased serum lactate (HP:0002151)	2.42171360
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40516268
40	Optic disc pallor (HP:0000543)	2.37579972
41	Exertional dyspnea (HP:0002875)	2.37432045
42	Congenital stationary night blindness (HP:0007642)	2.37235338
43	Hyperglycinemia (HP:0002154)	2.36049689
44	Rib fusion (HP:0000902)	2.33996855
45	Testicular atrophy (HP:0000029)	2.33878600
46	True hermaphroditism (HP:0010459)	2.33248665
47	Abnormal respiratory motile cilium physiology (HP:0012261)	2.32151810
48	Polydipsia (HP:0001959)	2.28078492
49	Abnormal drinking behavior (HP:0030082)	2.28078492
50	Microretrognathia (HP:0000308)	2.27005926
51	Adrenal hypoplasia (HP:0000835)	2.26255836
52	Abnormal ciliary motility (HP:0012262)	2.23502037
53	Hypoplasia of the radius (HP:0002984)	2.23160892
54	Increased muscle lipid content (HP:0009058)	2.22181856
55	Depressed nasal ridge (HP:0000457)	2.19439597
56	Lactic acidosis (HP:0003128)	2.18594854
57	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.17571886
58	Myokymia (HP:0002411)	2.15840743
59	Abnormality of magnesium homeostasis (HP:0004921)	2.11863428
60	Respiratory failure (HP:0002878)	2.11332724
61	Chronic bronchitis (HP:0004469)	2.09307097
62	Chronic hepatic failure (HP:0100626)	2.08063219
63	Sclerocornea (HP:0000647)	2.07332396
64	Nephronophthisis (HP:0000090)	2.07245832
65	Exercise intolerance (HP:0003546)	2.05585524
66	Cystic liver disease (HP:0006706)	2.04125020
67	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.03045661
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.03045661
69	Medial flaring of the eyebrow (HP:0010747)	2.01954896
70	Double outlet right ventricle (HP:0001719)	2.01409826
71	Congenital malformation of the right heart (HP:0011723)	2.01409826
72	Polyuria (HP:0000103)	2.00475240
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.97502318
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.97502318
75	Partial duplication of thumb phalanx (HP:0009944)	1.95116027
76	Hypomagnesemia (HP:0002917)	1.94784875
77	Leukodystrophy (HP:0002415)	1.93714279
78	Anencephaly (HP:0002323)	1.93304354
79	Horseshoe kidney (HP:0000085)	1.93274535
80	Lethargy (HP:0001254)	1.92532434
81	Abnormal biliary tract physiology (HP:0012439)	1.91072586
82	Bile duct proliferation (HP:0001408)	1.91072586
83	Severe visual impairment (HP:0001141)	1.89519576
84	Triphalangeal thumb (HP:0001199)	1.88499325
85	Respiratory difficulties (HP:0002880)	1.84345779
86	Abnormality of renal resorption (HP:0011038)	1.82518823
87	11 pairs of ribs (HP:0000878)	1.82474511
88	Anophthalmia (HP:0000528)	1.81217399
89	Abnormality of urine glucose concentration (HP:0011016)	1.81180383
90	Glycosuria (HP:0003076)	1.81180383
91	Abnormality of the renal cortex (HP:0011035)	1.79583647
92	Supernumerary spleens (HP:0009799)	1.75349637
93	Congenital, generalized hypertrichosis (HP:0004540)	1.75153104
94	Pachygyria (HP:0001302)	1.74908570
95	Methylmalonic acidemia (HP:0002912)	1.73168625
96	Forearm undergrowth (HP:0009821)	1.72147321
97	Impulsivity (HP:0100710)	1.72061600
98	Hyperphosphaturia (HP:0003109)	1.70374015
99	Abnormal urine output (HP:0012590)	1.69669927
100	Methylmalonic aciduria (HP:0012120)	1.68766831

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	4.58454172
2	TIE1	3.78380281
3	NME2	3.62223623
4	LIMK1	3.08355283
5	ADRBK2	2.56285210
6	ZAK	2.45755256
7	DYRK2	2.43913395
8	GRK1	2.23440752
9	VRK2	2.20550742
10	TXK	2.16428131
11	BCKDK	2.01887474
12	LRRK2	1.96252947
13	WNK4	1.92701350
14	CDC7	1.91001820
15	CDK8	1.85168179
16	EPHB2	1.74825495
17	NUAK1	1.72044245
18	CDK19	1.60013664
19	BRSK1	1.58087735
20	CAMKK2	1.53002710
21	SRPK1	1.46166574
22	BMPR1B	1.43617564
23	TLK1	1.43612599
24	AURKA	1.29517329
25	BUB1	1.25294551
26	PIK3CA	1.19702330
27	CAMK1	1.17017919
28	PLK4	1.12791645
29	INSRR	1.11949404
30	WNK3	1.10550701
31	NME1	1.10001025
32	NEK1	1.09877378
33	TNIK	1.05990025
34	CDC42BPA	1.04399365
35	KDR	1.04354857
36	STK24	1.03669835
37	PINK1	1.01989682
38	AURKB	1.00571370
39	PASK	0.99054257
40	NTRK2	0.97153899
41	PRKCG	0.95065239
42	CSNK2A2	0.94377034
43	MAP4K2	0.91174692
44	NEK2	0.90853736
45	MINK1	0.90490829
46	CAMK1D	0.90367590
47	MAP4K1	0.87463174
48	EIF2AK1	0.85917445
49	MAP2K7	0.85566826
50	PTK6	0.84199860
51	MAP3K11	0.82789527
52	ADRBK1	0.82190924
53	CAMKK1	0.82031253
54	DMPK	0.81260136
55	VRK1	0.76664597
56	PLK1	0.76651605
57	EPHA4	0.76567465
58	ABL2	0.71736037
59	CHEK2	0.71493981
60	RPS6KB2	0.69575079
61	ILK	0.68429118
62	CSNK2A1	0.68335113
63	DYRK3	0.68291768
64	TEC	0.66715334
65	ATR	0.65373374
66	PIM2	0.63425750
67	CASK	0.63036187
68	TTK	0.62645224
69	MARK2	0.62546997
70	CSNK1E	0.60561686
71	PRKCI	0.60061694
72	PRKCQ	0.60052827
73	PAK3	0.59571306
74	PRKACA	0.58262281
75	RPS6KA5	0.56835720
76	MAP3K4	0.56659190
77	FRK	0.52782511
78	DAPK3	0.52570894
79	MKNK2	0.51849672
80	PDK2	0.50728099
81	TGFBR1	0.48166906
82	STK11	0.47671488
83	TRIM28	0.46730145
84	CHEK1	0.46136835
85	TAF1	0.44463750
86	OBSCN	0.44114136
87	BRSK2	0.42731703
88	PLK3	0.39756718
89	TYRO3	0.39661899
90	CAMK1G	0.38923469
91	MAPK15	0.37946148
92	GRK5	0.37871136
93	OXSR1	0.37864082
94	PRKCZ	0.37538410
95	IRAK4	0.37307942
96	WNK1	0.37225184
97	MAPK13	0.36182422
98	STK4	0.35040729
99	PRKCA	0.34665595
100	PRKDC	0.34503259

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.91854926
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.64250982
3	Parkinsons disease_Homo sapiens_hsa05012	3.83609152
4	Huntingtons disease_Homo sapiens_hsa05016	2.84486153
5	RNA polymerase_Homo sapiens_hsa03020	2.68806727
6	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.65250422
7	Alzheimers disease_Homo sapiens_hsa05010	2.61616131
8	Cardiac muscle contraction_Homo sapiens_hsa04260	2.53500584
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13636126
10	Homologous recombination_Homo sapiens_hsa03440	2.04318849
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.97398531
12	Protein export_Homo sapiens_hsa03060	1.93659929
13	Proteasome_Homo sapiens_hsa03050	1.82824124
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.78604931
15	RNA degradation_Homo sapiens_hsa03018	1.58260646
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.56492245
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54018159
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.46875406
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.46656752
20	One carbon pool by folate_Homo sapiens_hsa00670	1.45542546
21	Basal transcription factors_Homo sapiens_hsa03022	1.42452016
22	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38402527
23	Spliceosome_Homo sapiens_hsa03040	1.32602264
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.32413271
25	Mismatch repair_Homo sapiens_hsa03430	1.30693865
26	DNA replication_Homo sapiens_hsa03030	1.29290999
27	Sulfur relay system_Homo sapiens_hsa04122	1.26537106
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.19356297
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.17820713
30	Peroxisome_Homo sapiens_hsa04146	1.04736028
31	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.98929780
32	Purine metabolism_Homo sapiens_hsa00230	0.95762921
33	Nicotine addiction_Homo sapiens_hsa05033	0.94745125
34	Tryptophan metabolism_Homo sapiens_hsa00380	0.94468866
35	Base excision repair_Homo sapiens_hsa03410	0.92816713
36	Nitrogen metabolism_Homo sapiens_hsa00910	0.92279647
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91610919
38	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90633732
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86698518
40	Propanoate metabolism_Homo sapiens_hsa00640	0.85860987
41	RNA transport_Homo sapiens_hsa03013	0.85521563
42	Metabolic pathways_Homo sapiens_hsa01100	0.81292288
43	Asthma_Homo sapiens_hsa05310	0.80621602
44	Butanoate metabolism_Homo sapiens_hsa00650	0.80113624
45	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.78753008
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.76349212
47	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.74248980
48	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72696929
49	Phototransduction_Homo sapiens_hsa04744	0.70547207
50	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.70362079
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.68332609
52	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63956408
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55734051
54	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.55382527
55	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.54386219
56	Retinol metabolism_Homo sapiens_hsa00830	0.53144224
57	Caffeine metabolism_Homo sapiens_hsa00232	0.52477809
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.52123889
59	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51737103
60	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.51100876
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50392587
62	Sulfur metabolism_Homo sapiens_hsa00920	0.50027140
63	Fatty acid degradation_Homo sapiens_hsa00071	0.49733019
64	Pyruvate metabolism_Homo sapiens_hsa00620	0.48108106
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47356379
66	Morphine addiction_Homo sapiens_hsa05032	0.46792868
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.43786535
68	Folate biosynthesis_Homo sapiens_hsa00790	0.43496392
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43340363
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.43290037
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.43091292
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.42368991
73	Olfactory transduction_Homo sapiens_hsa04740	0.41196177
74	Primary immunodeficiency_Homo sapiens_hsa05340	0.39029640
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.38900710
76	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.38356903
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.37110279
78	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.36173312
79	Insulin secretion_Homo sapiens_hsa04911	0.36151157
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.35764798
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.35458354
82	Regulation of autophagy_Homo sapiens_hsa04140	0.35350710
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.34578849
84	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.33510451
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33276016
86	Allograft rejection_Homo sapiens_hsa05330	0.33016358
87	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.32456102
88	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.30379960
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30295684
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.29135344
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.26325775
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.26296728
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.24999429
94	Phenylalanine metabolism_Homo sapiens_hsa00360	0.23176531
95	Fatty acid elongation_Homo sapiens_hsa00062	0.21337044
96	Mineral absorption_Homo sapiens_hsa04978	0.19536828
97	Glutathione metabolism_Homo sapiens_hsa00480	0.17610920
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.15866351
99	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.14016444
100	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.13439482

RPL36AP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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