ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	8.37404955
2	ATP synthesis coupled proton transport (GO:0015986)	8.37404955
3	viral transcription (GO:0019083)	8.37039385
4	translational termination (GO:0006415)	8.05178171
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	7.99355397
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.38079645
7	cotranslational protein targeting to membrane (GO:0006613)	7.22487256
8	ribosomal small subunit biogenesis (GO:0042274)	7.17345066
9	protein targeting to ER (GO:0045047)	7.16568392
10	ribosomal small subunit assembly (GO:0000028)	6.99880473
11	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.90218416
12	protein localization to endoplasmic reticulum (GO:0070972)	6.80471157
13	translational elongation (GO:0006414)	6.65415088
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	6.56804553
15	respiratory electron transport chain (GO:0022904)	6.37188191
16	electron transport chain (GO:0022900)	6.20251275
17	cellular protein complex disassembly (GO:0043624)	6.07878128
18	viral life cycle (GO:0019058)	5.87633724
19	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.85056336
20	maturation of SSU-rRNA (GO:0030490)	5.65222598
21	ribosomal large subunit biogenesis (GO:0042273)	5.58335263
22	translational initiation (GO:0006413)	5.45627798
23	protein targeting to membrane (GO:0006612)	4.99156206
24	protein complex disassembly (GO:0043241)	4.98538866
25	translation (GO:0006412)	4.86330239
26	positive regulation of mast cell degranulation (GO:0043306)	4.83395313
27	positive regulation of mast cell activation involved in immune response (GO:0033008)	4.83395313
28	macromolecular complex disassembly (GO:0032984)	4.78203990
29	ATP biosynthetic process (GO:0006754)	4.64960581
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.57349690
31	NADH dehydrogenase complex assembly (GO:0010257)	4.57349690
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.57349690
33	regulation of cellular respiration (GO:0043457)	4.54855392
34	protein neddylation (GO:0045116)	4.46267824
35	regulation of hypersensitivity (GO:0002883)	4.43412960
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.41582373
37	chaperone-mediated protein transport (GO:0072321)	4.39877599
38	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.33602320
39	protein complex biogenesis (GO:0070271)	4.23517260
40	positive regulation of mast cell activation (GO:0033005)	4.20968496
41	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.18101091
42	hydrogen ion transmembrane transport (GO:1902600)	4.07065351
43	mRNA catabolic process (GO:0006402)	3.92566215
44	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.86289726
45	mitochondrial respiratory chain complex assembly (GO:0033108)	3.85425784
46	proteasome assembly (GO:0043248)	3.75254050
47	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.74913996
48	termination of RNA polymerase III transcription (GO:0006386)	3.74913996
49	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.72228960
50	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	3.70782366
51	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.68508621
52	proton transport (GO:0015992)	3.67901526
53	GTP biosynthetic process (GO:0006183)	3.67551383
54	RNA catabolic process (GO:0006401)	3.61559705
55	hydrogen transport (GO:0006818)	3.60623860
56	oxidative phosphorylation (GO:0006119)	3.60161471
57	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.58114993
58	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.57561814
59	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.56421823
60	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.56421823
61	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.54011538
62	establishment of protein localization to membrane (GO:0090150)	3.52509610
63	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.40228808
64	protein targeting (GO:0006605)	3.38665687
65	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.38574056
66	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.37110588
67	protein targeting to mitochondrion (GO:0006626)	3.33544360
68	deoxyribose phosphate catabolic process (GO:0046386)	3.33426888
69	nucleoside triphosphate biosynthetic process (GO:0009142)	3.31967079
70	negative regulation of heart rate (GO:0010459)	3.27300920
71	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	3.26096656
72	deoxyribonucleotide catabolic process (GO:0009264)	3.24489908
73	aldehyde catabolic process (GO:0046185)	3.23955985
74	cellular component biogenesis (GO:0044085)	3.18882518
75	one-carbon compound transport (GO:0019755)	3.18172359
76	spliceosomal complex assembly (GO:0000245)	3.16246314
77	pyrimidine nucleotide catabolic process (GO:0006244)	3.11779251
78	UTP biosynthetic process (GO:0006228)	3.10202460
79	ribonucleoprotein complex biogenesis (GO:0022613)	3.04446980
80	establishment of protein localization to organelle (GO:0072594)	2.99588238
81	protein localization to mitochondrion (GO:0070585)	2.99066866
82	establishment of protein localization to mitochondrion (GO:0072655)	2.95801178
83	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.93839170
84	immunoglobulin mediated immune response (GO:0016064)	2.93577277
85	respiratory chain complex IV assembly (GO:0008535)	2.89984727
86	mitochondrial transport (GO:0006839)	2.89765923
87	anterograde synaptic vesicle transport (GO:0048490)	2.87614929
88	guanosine-containing compound biosynthetic process (GO:1901070)	2.86867208
89	purine deoxyribonucleotide catabolic process (GO:0009155)	2.85977539
90	positive regulation of vesicle fusion (GO:0031340)	2.85186401
91	UTP metabolic process (GO:0046051)	2.84323557
92	protein localization to membrane (GO:0072657)	2.82527380
93	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81813933
94	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.79605389
95	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.79605389
96	GPI anchor biosynthetic process (GO:0006506)	2.77925069
97	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.74443717
98	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.73709148
99	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.69065254
100	aerobic respiration (GO:0009060)	2.65738972

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.95558283
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24792508
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.66660537
4	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.66639923
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56440555
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.37314421
7	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.00177332
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.93800806
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73137925
10	EZH2_22144423_ChIP-Seq_EOC_Human	2.62227071
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.57317216
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.47768067
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.36421179
14	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.35741754
15	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.25760856
16	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19903145
17	ELK1_19687146_ChIP-ChIP_HELA_Human	2.18196431
18	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.16448203
19	FOXP3_21729870_ChIP-Seq_TREG_Human	2.13714309
20	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.08889565
21	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.08104574
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.05256080
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.04982561
24	TTF2_22483619_ChIP-Seq_HELA_Human	1.92718345
25	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.92422446
26	VDR_22108803_ChIP-Seq_LS180_Human	1.86953704
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76323058
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.70579855
29	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.63030668
30	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.60812943
31	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.51111255
32	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.50148005
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.49296844
34	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.49100875
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.46607948
36	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.43149919
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.42311047
38	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.37957508
39	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.34643541
40	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31706545
41	TAF2_19829295_ChIP-Seq_ESCs_Human	1.30362797
42	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28043867
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.26672041
44	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.23888442
45	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.21996645
46	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.21820311
47	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.21279473
48	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.21147610
49	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.19840853
50	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.19506864
51	STAT1_20625510_ChIP-Seq_HELA_Human	1.19367179
52	TP53_22573176_ChIP-Seq_HFKS_Human	1.19312114
53	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.16747209
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.16695502
55	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.16044215
56	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.15111688
57	SPI1_23547873_ChIP-Seq_NB4_Human	1.14207389
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.12904407
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12429104
60	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11949649
61	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11664841
62	TAF15_26573619_Chip-Seq_HEK293_Human	1.11445623
63	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.10210424
64	AR_20517297_ChIP-Seq_VCAP_Human	1.10183904
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09932255
66	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06362047
67	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.06040511
68	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04984323
69	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04526167
70	EWS_26573619_Chip-Seq_HEK293_Human	1.04161240
71	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.02800936
72	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.02395833
73	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.02256270
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02237991
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02237991
76	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00090962
77	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.98476918
78	ERG_20517297_ChIP-Seq_VCAP_Human	0.96935865
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96020141
80	CIITA_25753668_ChIP-Seq_RAJI_Human	0.95406112
81	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.93262038
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.92278940
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.92084451
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.91068267
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.91068267
86	BCL6_27268052_Chip-Seq_Bcells_Human	0.90980341
87	FUS_26573619_Chip-Seq_HEK293_Human	0.90659886
88	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.90415313
89	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.89373828
90	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.89023814
91	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88779102
92	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.87390050
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.87079120
94	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86931128
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.86513439
96	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.86348025
97	SPI1_20517297_ChIP-Seq_HL60_Human	0.83327796
98	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.82654899
99	NCOR_22424771_ChIP-Seq_293T_Human	0.82184460
100	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.82002815

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	8.61613378
2	MP0001835_abnormal_antigen_presentation	4.47711452
3	MP0003806_abnormal_nucleotide_metabolis	3.09446394
4	MP0005646_abnormal_pituitary_gland	2.95715063
5	MP0000516_abnormal_urinary_system	2.80799504
6	MP0005367_renal/urinary_system_phenotyp	2.80799504
7	MP0005671_abnormal_response_to	2.73953729
8	MP0004142_abnormal_muscle_tone	2.59499112
9	MP0006292_abnormal_olfactory_placode	2.50321127
10	MP0006036_abnormal_mitochondrial_physio	2.41321357
11	MP0001529_abnormal_vocalization	2.40161937
12	MP0003646_muscle_fatigue	2.11554299
13	MP0004145_abnormal_muscle_electrophysio	2.11129823
14	MP0003186_abnormal_redox_activity	2.04781148
15	MP0002163_abnormal_gland_morphology	2.01547270
16	MP0005670_abnormal_white_adipose	1.87641052
17	MP0004147_increased_porphyrin_level	1.85706486
18	MP0005075_abnormal_melanosome_morpholog	1.82252441
19	MP0002876_abnormal_thyroid_physiology	1.78567820
20	MP0002837_dystrophic_cardiac_calcinosis	1.70957845
21	MP0008875_abnormal_xenobiotic_pharmacok	1.68872018
22	MP0008789_abnormal_olfactory_epithelium	1.60528325
23	MP0009764_decreased_sensitivity_to	1.58817364
24	MP0009046_muscle_twitch	1.58525721
25	MP0005360_urolithiasis	1.58405714
26	MP0001905_abnormal_dopamine_level	1.57891244
27	MP0000372_irregular_coat_pigmentation	1.56032493
28	MP0009785_altered_susceptibility_to	1.43964175
29	MP0002090_abnormal_vision	1.43831452
30	MP0005408_hypopigmentation	1.42072905
31	MP0004885_abnormal_endolymph	1.37104359
32	MP0000569_abnormal_digit_pigmentation	1.36348859
33	MP0002148_abnormal_hypersensitivity_rea	1.29415367
34	MP0001800_abnormal_humoral_immune	1.28504824
35	MP0005174_abnormal_tail_pigmentation	1.27644106
36	MP0002095_abnormal_skin_pigmentation	1.25600751
37	MP0001188_hyperpigmentation	1.23254646
38	MP0003315_abnormal_perineum_morphology	1.22504364
39	MP0001986_abnormal_taste_sensitivity	1.22293457
40	MP0001756_abnormal_urination	1.17209959
41	MP0005394_taste/olfaction_phenotype	1.14655173
42	MP0005499_abnormal_olfactory_system	1.14655173
43	MP0005332_abnormal_amino_acid	1.13397495
44	MP0008872_abnormal_physiological_respon	1.11919482
45	MP0001486_abnormal_startle_reflex	1.08920905
46	MP0001970_abnormal_pain_threshold	1.07938547
47	MP0005636_abnormal_mineral_homeostasis	1.06384743
48	MP0005379_endocrine/exocrine_gland_phen	1.05841901
49	MP0000049_abnormal_middle_ear	1.05082122
50	MP0002272_abnormal_nervous_system	1.04252162
51	MP0001984_abnormal_olfaction	1.04154957
52	MP0000685_abnormal_immune_system	1.03248569
53	MP0001440_abnormal_grooming_behavior	1.02798198
54	MP0002452_abnormal_antigen_presenting	0.99916156
55	MP0005085_abnormal_gallbladder_physiolo	0.96891427
56	MP0002938_white_spotting	0.96637636
57	MP0006082_CNS_inflammation	0.95601880
58	MP0005551_abnormal_eye_electrophysiolog	0.94022918
59	MP0006072_abnormal_retinal_apoptosis	0.92213608
60	MP0003880_abnormal_central_pattern	0.87178483
61	MP0003786_premature_aging	0.86769130
62	MP0002234_abnormal_pharynx_morphology	0.83725756
63	MP0009745_abnormal_behavioral_response	0.83599715
64	MP0005187_abnormal_penis_morphology	0.83006670
65	MP0005535_abnormal_body_temperature	0.82259458
66	MP0005000_abnormal_immune_tolerance	0.81137760
67	MP0001873_stomach_inflammation	0.80680225
68	MP0005377_hearing/vestibular/ear_phenot	0.77310416
69	MP0003878_abnormal_ear_physiology	0.77310416
70	MP0000681_abnormal_thyroid_gland	0.76559234
71	MP0000631_abnormal_neuroendocrine_gland	0.74575010
72	MP0002723_abnormal_immune_serum	0.74047809
73	MP0001324_abnormal_eye_pigmentation	0.72928122
74	MP0005645_abnormal_hypothalamus_physiol	0.72788313
75	MP0001663_abnormal_digestive_system	0.72217425
76	MP0002166_altered_tumor_susceptibility	0.71605138
77	MP0005195_abnormal_posterior_eye	0.71474826
78	MP0010386_abnormal_urinary_bladder	0.71426402
79	MP0001485_abnormal_pinna_reflex	0.71258820
80	MP0005025_abnormal_response_to	0.70706172
81	MP0006276_abnormal_autonomic_nervous	0.70268525
82	MP0001764_abnormal_homeostasis	0.69894928
83	MP0002638_abnormal_pupillary_reflex	0.69116896
84	MP0000534_abnormal_ureter_morphology	0.67993924
85	MP0010030_abnormal_orbit_morphology	0.67851315
86	MP0005389_reproductive_system_phenotype	0.67459985
87	MP0001765_abnormal_ion_homeostasis	0.67135512
88	MP0005166_decreased_susceptibility_to	0.66678511
89	MP0009333_abnormal_splenocyte_physiolog	0.65621771
90	MP0001819_abnormal_immune_cell	0.64240881
91	MP0003075_altered_response_to	0.63039981
92	MP0003136_yellow_coat_color	0.62330503
93	MP0000678_abnormal_parathyroid_gland	0.62075067
94	MP0003011_delayed_dark_adaptation	0.59659504
95	MP0002064_seizures	0.59570246
96	MP0009053_abnormal_anal_canal	0.59506017
97	MP0009643_abnormal_urine_homeostasis	0.58331574
98	MP0008469_abnormal_protein_level	0.58184994
99	MP0002160_abnormal_reproductive_system	0.57325739
100	MP0002420_abnormal_adaptive_immunity	0.56938907

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.61126673
2	Abnormal mitochondria in muscle tissue (HP:0008316)	6.07590072
3	Hepatocellular necrosis (HP:0001404)	6.00829281
4	Mitochondrial inheritance (HP:0001427)	5.89980794
5	Progressive macrocephaly (HP:0004481)	5.53618919
6	Acute encephalopathy (HP:0006846)	5.41404741
7	Hepatic necrosis (HP:0002605)	5.27182301
8	Increased CSF lactate (HP:0002490)	5.20153329
9	3-Methylglutaconic aciduria (HP:0003535)	5.00836217
10	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.72738867
11	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.72738867
12	Increased hepatocellular lipid droplets (HP:0006565)	4.54749189
13	Lipid accumulation in hepatocytes (HP:0006561)	4.45132523
14	Renal Fanconi syndrome (HP:0001994)	4.27065961
15	Macrocytic anemia (HP:0001972)	4.12455231
16	Cerebral edema (HP:0002181)	4.11179432
17	Increased intramyocellular lipid droplets (HP:0012240)	4.10479843
18	Exertional dyspnea (HP:0002875)	3.96397265
19	Reticulocytopenia (HP:0001896)	3.91190541
20	Increased muscle lipid content (HP:0009058)	3.70361528
21	Congenital, generalized hypertrichosis (HP:0004540)	3.54245310
22	Pallor (HP:0000980)	3.52325433
23	Abnormality of cells of the erythroid lineage (HP:0012130)	3.48620760
24	Abnormal hemoglobin (HP:0011902)	3.47070316
25	Leukodystrophy (HP:0002415)	3.41867001
26	Respiratory failure (HP:0002878)	3.37710289
27	Myokymia (HP:0002411)	3.14297719
28	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.12963796
29	Respiratory difficulties (HP:0002880)	3.10989132
30	Increased serum lactate (HP:0002151)	3.07162952
31	Absent/shortened dynein arms (HP:0200106)	3.06914992
32	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.06914992
33	Lactic acidosis (HP:0003128)	3.04567857
34	Obstructive lung disease (HP:0006536)	2.79549728
35	Chronic obstructive pulmonary disease (HP:0006510)	2.79549728
36	Optic disc pallor (HP:0000543)	2.79359451
37	Abnormality of renal resorption (HP:0011038)	2.75009774
38	Abnormal number of erythroid precursors (HP:0012131)	2.70174909
39	CNS demyelination (HP:0007305)	2.67942205
40	Microretrognathia (HP:0000308)	2.66339157
41	Aplastic anemia (HP:0001915)	2.64346474
42	Exercise intolerance (HP:0003546)	2.58648580
43	Molar tooth sign on MRI (HP:0002419)	2.53868403
44	Abnormality of midbrain morphology (HP:0002418)	2.53868403
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.48023122
46	Cleft eyelid (HP:0000625)	2.34721811
47	Abnormality of alanine metabolism (HP:0010916)	2.26508187
48	Hyperalaninemia (HP:0003348)	2.26508187
49	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.26508187
50	Lethargy (HP:0001254)	2.25790430
51	Glycosuria (HP:0003076)	2.23224781
52	Abnormality of urine glucose concentration (HP:0011016)	2.23224781
53	Generalized aminoaciduria (HP:0002909)	2.21318398
54	Multiple enchondromatosis (HP:0005701)	2.15992684
55	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.10087438
56	X-linked dominant inheritance (HP:0001423)	2.08269515
57	Emotional lability (HP:0000712)	2.01414276
58	Hyperphosphaturia (HP:0003109)	2.00827318
59	Radial bowing (HP:0002986)	1.97775297
60	Abnormal respiratory epithelium morphology (HP:0012253)	1.96344868
61	Abnormal respiratory motile cilium morphology (HP:0005938)	1.96344868
62	Stenosis of the external auditory canal (HP:0000402)	1.96056684
63	Decreased central vision (HP:0007663)	1.95671875
64	Rectal fistula (HP:0100590)	1.93679906
65	Rectovaginal fistula (HP:0000143)	1.93679906
66	Blindness (HP:0000618)	1.88908774
67	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.88373937
68	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.88271772
69	Concave nail (HP:0001598)	1.87910609
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.84939612
71	Porencephaly (HP:0002132)	1.84496116
72	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.83803416
73	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	1.83454031
74	Testicular atrophy (HP:0000029)	1.82718340
75	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.82268373
76	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.80031783
77	Abnormal ciliary motility (HP:0012262)	1.79819341
78	Vomiting (HP:0002013)	1.77705450
79	Ureteral stenosis (HP:0000071)	1.77624598
80	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.74100458
81	Triphalangeal thumb (HP:0001199)	1.73634049
82	Hemoptysis (HP:0002105)	1.73045425
83	Pancreatic cysts (HP:0001737)	1.71801233
84	Abnormality of the prostate (HP:0008775)	1.71295728
85	Alveolar cell carcinoma (HP:0006519)	1.71116442
86	Gliosis (HP:0002171)	1.70852418
87	Abolished electroretinogram (ERG) (HP:0000550)	1.69997250
88	Medial flaring of the eyebrow (HP:0010747)	1.68541142
89	Abnormal rod and cone electroretinograms (HP:0008323)	1.68090062
90	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.67613220
91	Median cleft lip (HP:0000161)	1.64526760
92	Congenital stationary night blindness (HP:0007642)	1.63971380
93	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	1.61245667
94	Short middle phalanx of the 5th finger (HP:0004220)	1.60223077
95	Woolly hair (HP:0002224)	1.60091940
96	Gait imbalance (HP:0002141)	1.59936571
97	Hypoplasia of the radius (HP:0002984)	1.59234494
98	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.58658721
99	Abnormality of magnesium homeostasis (HP:0004921)	1.58395580
100	Hypoproteinemia (HP:0003075)	1.56986664

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	5.91387412
2	BMPR2	5.06603112
3	MAP3K12	4.78939591
4	NME2	4.29188801
5	MYLK	3.11723605
6	ILK	2.80787258
7	SCYL2	2.54428994
8	TLK1	2.17339195
9	MAP4K2	2.07843359
10	CSF1R	1.85765317
11	BCKDK	1.84312259
12	NUAK1	1.77676795
13	NEK1	1.71648889
14	OXSR1	1.71556229
15	DYRK2	1.69411086
16	DAPK3	1.69309789
17	PDK2	1.45386687
18	FLT3	1.44625120
19	AKT3	1.37324120
20	STK16	1.33599542
21	LRRK2	1.31485129
22	IKBKB	1.18819266
23	PIM2	1.15197420
24	PLK4	1.15065426
25	ARAF	1.13427523
26	KIT	1.13247324
27	DAPK1	1.12474293
28	MAP3K13	1.11826713
29	INSRR	1.10149315
30	GRK1	1.08011250
31	BRAF	1.01521710
32	ABL2	1.01433722
33	RPS6KA5	1.00679087
34	AURKB	0.98979998
35	LYN	0.98961915
36	WNK4	0.98799254
37	GRK6	0.94359090
38	KDR	0.93956074
39	OBSCN	0.90949222
40	CSNK2A2	0.85551977
41	CAMK1	0.80011814
42	RPS6KA4	0.78175994
43	ZAK	0.77091452
44	FES	0.77073990
45	VRK2	0.76977801
46	TXK	0.75194808
47	TIE1	0.73525769
48	ERBB3	0.73222734
49	MUSK	0.69457067
50	FRK	0.68393660
51	CSNK2A1	0.67600472
52	PKN1	0.66738531
53	WNK3	0.64664099
54	ADRBK2	0.64612945
55	CDK8	0.63345193
56	TAOK2	0.61695441
57	DYRK1B	0.57449472
58	TEC	0.56979542
59	BTK	0.54425881
60	CSNK1G3	0.54146802
61	TAOK3	0.53667513
62	PRKACA	0.52956961
63	GRK7	0.52875658
64	CSNK1G2	0.52406472
65	TYK2	0.51748334
66	TRPM7	0.50731517
67	CDC7	0.50152264
68	PIM1	0.49943358
69	MOS	0.48850261
70	ADRBK1	0.48613802
71	PIK3CA	0.48486404
72	RIPK4	0.48201047
73	SYK	0.47678157
74	ROCK1	0.47649427
75	PRKG1	0.47096411
76	PRKCD	0.45834853
77	MINK1	0.45444886
78	PRKCE	0.45043502
79	CDK3	0.44228575
80	PIK3CG	0.44204577
81	CDK11A	0.43274997
82	CDK14	0.41732713
83	PAK1	0.41501442
84	MAPKAPK5	0.40393177
85	PRKCA	0.38387249
86	DYRK3	0.38221178
87	CAMK2D	0.38132144
88	MATK	0.38078404
89	LCK	0.37210792
90	ITK	0.36889122
91	BMPR1B	0.36334204
92	EGFR	0.35343662
93	BLK	0.34935988
94	CSNK1A1	0.34248298
95	CSNK1E	0.33595998
96	CCNB1	0.32538174
97	MAPK15	0.32195478
98	CAMK2A	0.30961025
99	CSNK1A1L	0.30615645
100	ATR	0.29999971

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.58187467
2	Ribosome_Homo sapiens_hsa03010	5.18656072
3	Oxidative phosphorylation_Homo sapiens_hsa00190	4.47529266
4	Allograft rejection_Homo sapiens_hsa05330	3.79948882
5	Parkinsons disease_Homo sapiens_hsa05012	3.71496329
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.66408516
7	Graft-versus-host disease_Homo sapiens_hsa05332	3.48118435
8	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.35288017
9	Type I diabetes mellitus_Homo sapiens_hsa04940	3.04058623
10	Protein export_Homo sapiens_hsa03060	2.78808160
11	Huntingtons disease_Homo sapiens_hsa05016	2.57719780
12	Alzheimers disease_Homo sapiens_hsa05010	2.54803549
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.36306662
14	Cardiac muscle contraction_Homo sapiens_hsa04260	2.24007327
15	Proteasome_Homo sapiens_hsa03050	2.20559385
16	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.08403766
17	Viral myocarditis_Homo sapiens_hsa05416	2.05416981
18	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.85051001
19	Rheumatoid arthritis_Homo sapiens_hsa05323	1.84735001
20	RNA polymerase_Homo sapiens_hsa03020	1.80675861
21	Antigen processing and presentation_Homo sapiens_hsa04612	1.70885821
22	Leishmaniasis_Homo sapiens_hsa05140	1.47835433
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.34076389
24	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.22827393
25	One carbon pool by folate_Homo sapiens_hsa00670	1.14413849
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.09865315
27	Homologous recombination_Homo sapiens_hsa03440	0.90678090
28	RNA degradation_Homo sapiens_hsa03018	0.79943533
29	DNA replication_Homo sapiens_hsa03030	0.73136007
30	Pyrimidine metabolism_Homo sapiens_hsa00240	0.72860326
31	Regulation of autophagy_Homo sapiens_hsa04140	0.71981917
32	Mismatch repair_Homo sapiens_hsa03430	0.66872509
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65933844
34	Phagosome_Homo sapiens_hsa04145	0.65150130
35	Linoleic acid metabolism_Homo sapiens_hsa00591	0.64922469
36	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.61395069
37	Spliceosome_Homo sapiens_hsa03040	0.61019051
38	Collecting duct acid secretion_Homo sapiens_hsa04966	0.60699754
39	Toxoplasmosis_Homo sapiens_hsa05145	0.59457880
40	Tuberculosis_Homo sapiens_hsa05152	0.57291548
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.49973999
42	Sulfur relay system_Homo sapiens_hsa04122	0.49792914
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49726676
44	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.47703425
45	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.46991599
46	Olfactory transduction_Homo sapiens_hsa04740	0.46396240
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46214914
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.45405996
49	Nucleotide excision repair_Homo sapiens_hsa03420	0.43115745
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43098469
51	Phototransduction_Homo sapiens_hsa04744	0.42979655
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.42433141
53	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.41273182
54	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.40876194
55	Metabolic pathways_Homo sapiens_hsa01100	0.39788095
56	Purine metabolism_Homo sapiens_hsa00230	0.39542603
57	Influenza A_Homo sapiens_hsa05164	0.37954710
58	RNA transport_Homo sapiens_hsa03013	0.37510638
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36845166
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.36376070
61	Tyrosine metabolism_Homo sapiens_hsa00350	0.36352675
62	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.35712940
63	Fanconi anemia pathway_Homo sapiens_hsa03460	0.35398595
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32307053
65	African trypanosomiasis_Homo sapiens_hsa05143	0.29729639
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.29583611
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.29173190
68	Herpes simplex infection_Homo sapiens_hsa05168	0.26296127
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.26125599
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.25762445
71	Peroxisome_Homo sapiens_hsa04146	0.25505017
72	Fatty acid degradation_Homo sapiens_hsa00071	0.25365075
73	Phenylalanine metabolism_Homo sapiens_hsa00360	0.25291815
74	Nicotine addiction_Homo sapiens_hsa05033	0.23688183
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.23188307
76	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22082598
77	Nitrogen metabolism_Homo sapiens_hsa00910	0.21772861
78	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.20961623
79	Retinol metabolism_Homo sapiens_hsa00830	0.19949658
80	Salmonella infection_Homo sapiens_hsa05132	0.19432767
81	Caffeine metabolism_Homo sapiens_hsa00232	0.17750988
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.15265699
83	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.14710408
84	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.14689004
85	Fatty acid elongation_Homo sapiens_hsa00062	0.14131999
86	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.13036457
87	Propanoate metabolism_Homo sapiens_hsa00640	0.11371277
88	Base excision repair_Homo sapiens_hsa03410	0.10230317
89	Malaria_Homo sapiens_hsa05144	0.10195987
90	Folate biosynthesis_Homo sapiens_hsa00790	0.07776893
91	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.06845695
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.06519619
93	Arginine and proline metabolism_Homo sapiens_hsa00330	0.05540623
94	Glutathione metabolism_Homo sapiens_hsa00480	0.05356542
95	Arginine biosynthesis_Homo sapiens_hsa00220	0.04850967
96	Bladder cancer_Homo sapiens_hsa05219	0.04717018
97	Pyruvate metabolism_Homo sapiens_hsa00620	0.04093927
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.03851347
99	Primary immunodeficiency_Homo sapiens_hsa05340	0.02062032
100	Butanoate metabolism_Homo sapiens_hsa00650	-0.0015758

RPL36AP29

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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