ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.13617391
2	response to pheromone (GO:0019236)	5.14096112
3	viral transcription (GO:0019083)	5.00157876
4	translational termination (GO:0006415)	4.97050924
5	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.60237950
6	substrate-independent telencephalic tangential migration (GO:0021826)	4.60237950
7	ovulation cycle (GO:0042698)	4.32894147
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.32431604
9	cotranslational protein targeting to membrane (GO:0006613)	4.30098329
10	protein targeting to ER (GO:0045047)	4.23930749
11	ribosomal small subunit biogenesis (GO:0042274)	4.12325321
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.05157786
13	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.03917362
14	protein localization to endoplasmic reticulum (GO:0070972)	3.99547036
15	inner ear receptor cell development (GO:0060119)	3.95008967
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.93366879
17	maturation of SSU-rRNA (GO:0030490)	3.90574130
18	translational elongation (GO:0006414)	3.86761389
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.82006098
20	cellular protein complex disassembly (GO:0043624)	3.73019153
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72428919
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72428919
23	NADH dehydrogenase complex assembly (GO:0010257)	3.72428919
24	cell proliferation in forebrain (GO:0021846)	3.66832110
25	protein complex biogenesis (GO:0070271)	3.65422948
26	viral life cycle (GO:0019058)	3.65231164
27	nonmotile primary cilium assembly (GO:0035058)	3.63666439
28	ATP synthesis coupled proton transport (GO:0015986)	3.54859702
29	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.54859702
30	chaperone-mediated protein transport (GO:0072321)	3.48472749
31	respiratory chain complex IV assembly (GO:0008535)	3.48454128
32	behavioral response to nicotine (GO:0035095)	3.41365337
33	kynurenine metabolic process (GO:0070189)	3.40855071
34	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.32758030
35	respiratory electron transport chain (GO:0022904)	3.30135343
36	nucleobase catabolic process (GO:0046113)	3.28543722
37	electron transport chain (GO:0022900)	3.27551668
38	neuron fate determination (GO:0048664)	3.27038944
39	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.20676173
40	somite development (GO:0061053)	3.12879529
41	protein complex disassembly (GO:0043241)	3.11672281
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.10506282
43	neurofilament cytoskeleton organization (GO:0060052)	3.04853889
44	protein polyglutamylation (GO:0018095)	3.04484835
45	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.03641154
46	macromolecular complex disassembly (GO:0032984)	3.02241882
47	translational initiation (GO:0006413)	3.01384950
48	platelet dense granule organization (GO:0060155)	2.95435658
49	cytochrome complex assembly (GO:0017004)	2.95225910
50	hypothalamus development (GO:0021854)	2.92125933
51	glycerophospholipid catabolic process (GO:0046475)	2.87058881
52	regulation of cilium movement (GO:0003352)	2.86778283
53	protein neddylation (GO:0045116)	2.85253703
54	spinal cord association neuron differentiation (GO:0021527)	2.83745765
55	segment specification (GO:0007379)	2.83445984
56	amine catabolic process (GO:0009310)	2.80798928
57	cellular biogenic amine catabolic process (GO:0042402)	2.80798928
58	protein targeting to membrane (GO:0006612)	2.79639573
59	auditory receptor cell differentiation (GO:0042491)	2.77073961
60	regulation of transmission of nerve impulse (GO:0051969)	2.76024947
61	parturition (GO:0007567)	2.74868179
62	photoreceptor cell maintenance (GO:0045494)	2.74619076
63	microtubule severing (GO:0051013)	2.73255990
64	neuronal action potential propagation (GO:0019227)	2.71664430
65	indole-containing compound catabolic process (GO:0042436)	2.71544070
66	indolalkylamine catabolic process (GO:0046218)	2.71544070
67	tryptophan catabolic process (GO:0006569)	2.71544070
68	negative regulation of multicellular organism growth (GO:0040015)	2.70909043
69	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.70071872
70	epithelial cilium movement (GO:0003351)	2.69896642
71	tyrosine phosphorylation of STAT protein (GO:0007260)	2.69062122
72	translation (GO:0006412)	2.66077850
73	axon ensheathment in central nervous system (GO:0032291)	2.64927059
74	central nervous system myelination (GO:0022010)	2.64927059
75	anterograde synaptic vesicle transport (GO:0048490)	2.59366288
76	startle response (GO:0001964)	2.59204632
77	intraciliary transport (GO:0042073)	2.57418537
78	cardiovascular system development (GO:0072358)	2.57370838
79	negative regulation of systemic arterial blood pressure (GO:0003085)	2.55859352
80	hydrogen ion transmembrane transport (GO:1902600)	2.55439723
81	positive regulation of neurological system process (GO:0031646)	2.54447365
82	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.54173312
83	body morphogenesis (GO:0010171)	2.52530460
84	short-term memory (GO:0007614)	2.51835962
85	proton transport (GO:0015992)	2.50643363
86	water-soluble vitamin biosynthetic process (GO:0042364)	2.49510606
87	pattern specification involved in kidney development (GO:0061004)	2.47515144
88	ribosomal large subunit biogenesis (GO:0042273)	2.47131800
89	regulation of cellular respiration (GO:0043457)	2.46291685
90	dendritic spine morphogenesis (GO:0060997)	2.46272514
91	hydrogen transport (GO:0006818)	2.43936479
92	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.43360549
93	arginine catabolic process (GO:0006527)	2.43312991
94	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.40599138
95	retinal rod cell development (GO:0046548)	2.39857390
96	tongue development (GO:0043586)	2.38942305
97	positive regulation of prostaglandin secretion (GO:0032308)	2.38657330
98	positive regulation of organelle assembly (GO:1902117)	2.38182120
99	behavioral defense response (GO:0002209)	2.38075452
100	behavioral fear response (GO:0001662)	2.38075452

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.16971110
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.97924807
3	VDR_22108803_ChIP-Seq_LS180_Human	3.63401585
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.31559513
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.07415530
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.06375658
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.54524335
8	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.35429424
9	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.24927260
10	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.08164685
11	RNF2_27304074_Chip-Seq_NSC_Mouse	2.07356718
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03815683
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.91545122
14	FUS_26573619_Chip-Seq_HEK293_Human	1.87385669
15	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.83135350
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.78278700
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.71794856
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.70905638
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.66786206
20	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.65849549
21	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.62328613
22	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.61912830
23	P300_19829295_ChIP-Seq_ESCs_Human	1.58673016
24	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.53973517
25	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.53452574
26	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52506406
27	EWS_26573619_Chip-Seq_HEK293_Human	1.52219344
28	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51551567
29	GBX2_23144817_ChIP-Seq_PC3_Human	1.50979757
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.49061354
31	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.48400582
32	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.46286705
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44912029
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.42197251
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41825039
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39528588
37	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.39186577
38	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.36392396
39	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.35637834
40	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34434028
41	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.33575188
42	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31883873
43	MYC_18940864_ChIP-ChIP_HL60_Human	1.31660511
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.28172686
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27889019
46	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.27803842
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.26929419
48	TP53_22573176_ChIP-Seq_HFKS_Human	1.26851805
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.24526878
50	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.24277979
51	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.24277979
52	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23065436
53	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22684591
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.20948476
55	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18642524
56	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18061995
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17549890
58	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16315464
59	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.16062122
60	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.15975300
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15218425
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.15036231
63	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14477392
64	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.12824164
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.12575006
66	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.12248168
67	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09075684
68	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.08432024
69	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.08062080
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.08045557
71	AR_25329375_ChIP-Seq_VCAP_Human	1.07416758
72	JUN_21703547_ChIP-Seq_K562_Human	1.07037090
73	NCOR_22424771_ChIP-Seq_293T_Human	1.06903992
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04320156
75	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04312739
76	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03843498
77	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03843498
78	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.03683196
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03472863
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.03472863
81	RXR_22108803_ChIP-Seq_LS180_Human	1.03136530
82	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.02206000
83	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.02086408
84	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.02015378
85	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.01473286
86	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.01428883
87	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.00475000
88	ER_23166858_ChIP-Seq_MCF-7_Human	1.00223705
89	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.00168796
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99038711
91	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98820319
92	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97440847
93	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96836597
94	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.94431299
95	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.93947820
96	TCF4_23295773_ChIP-Seq_U87_Human	0.93766370
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93568159
98	CBP_20019798_ChIP-Seq_JUKART_Human	0.93568159
99	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.93197648
100	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.92676231

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	3.91482388
2	MP0003122_maternal_imprinting	3.69949473
3	MP0002163_abnormal_gland_morphology	3.66712989
4	MP0009379_abnormal_foot_pigmentation	3.61931984
5	MP0005646_abnormal_pituitary_gland	3.31935383
6	MP0008877_abnormal_DNA_methylation	3.28587858
7	MP0006292_abnormal_olfactory_placode	2.96652839
8	MP0003123_paternal_imprinting	2.69823035
9	MP0002638_abnormal_pupillary_reflex	2.38179125
10	MP0003121_genomic_imprinting	2.37607700
11	MP0008789_abnormal_olfactory_epithelium	2.30522129
12	MP0005645_abnormal_hypothalamus_physiol	2.23147780
13	MP0005379_endocrine/exocrine_gland_phen	2.09885084
14	MP0004142_abnormal_muscle_tone	2.06126193
15	MP0003878_abnormal_ear_physiology	2.04735269
16	MP0005377_hearing/vestibular/ear_phenot	2.04735269
17	MP0005499_abnormal_olfactory_system	2.04114349
18	MP0005394_taste/olfaction_phenotype	2.04114349
19	MP0000427_abnormal_hair_cycle	2.01806195
20	MP0006276_abnormal_autonomic_nervous	2.00104692
21	MP0001485_abnormal_pinna_reflex	1.91605436
22	MP0005187_abnormal_penis_morphology	1.91115500
23	MP0005551_abnormal_eye_electrophysiolog	1.88530212
24	MP0003315_abnormal_perineum_morphology	1.71664693
25	MP0002557_abnormal_social/conspecific_i	1.67643488
26	MP0009046_muscle_twitch	1.61206016
27	MP0000778_abnormal_nervous_system	1.61055612
28	MP0003890_abnormal_embryonic-extraembry	1.57567338
29	MP0002653_abnormal_ependyma_morphology	1.54679042
30	MP0003880_abnormal_central_pattern	1.47423905
31	MP0006072_abnormal_retinal_apoptosis	1.43534308
32	MP0001984_abnormal_olfaction	1.42826917
33	MP0002837_dystrophic_cardiac_calcinosis	1.40819623
34	MP0004133_heterotaxia	1.39444453
35	MP0002272_abnormal_nervous_system	1.36887420
36	MP0000631_abnormal_neuroendocrine_gland	1.36053455
37	MP0002233_abnormal_nose_morphology	1.35062137
38	MP0004885_abnormal_endolymph	1.34084334
39	MP0000566_synostosis	1.33066398
40	MP0003011_delayed_dark_adaptation	1.31538482
41	MP0005195_abnormal_posterior_eye	1.27618975
42	MP0003938_abnormal_ear_development	1.27013932
43	MP0003136_yellow_coat_color	1.25047941
44	MP0005084_abnormal_gallbladder_morpholo	1.24910123
45	MP0002160_abnormal_reproductive_system	1.23448225
46	MP0000049_abnormal_middle_ear	1.23144678
47	MP0008995_early_reproductive_senescence	1.22800955
48	MP0002102_abnormal_ear_morphology	1.22288242
49	MP0000955_abnormal_spinal_cord	1.21229081
50	MP0001293_anophthalmia	1.19101949
51	MP0001486_abnormal_startle_reflex	1.16047083
52	MP0002938_white_spotting	1.14129155
53	MP0001440_abnormal_grooming_behavior	1.11529876
54	MP0009745_abnormal_behavioral_response	1.11110203
55	MP0002752_abnormal_somatic_nervous	1.09266169
56	MP0001986_abnormal_taste_sensitivity	1.08359562
57	MP0000026_abnormal_inner_ear	1.06463545
58	MP0008872_abnormal_physiological_respon	1.05218170
59	MP0003755_abnormal_palate_morphology	1.05020431
60	MP0000613_abnormal_salivary_gland	1.03560265
61	MP0002736_abnormal_nociception_after	1.03520120
62	MP0004859_abnormal_synaptic_plasticity	1.01064509
63	MP0003937_abnormal_limbs/digits/tail_de	1.00188154
64	MP0010030_abnormal_orbit_morphology	0.98409027
65	MP0001970_abnormal_pain_threshold	0.97873752
66	MP0001968_abnormal_touch/_nociception	0.97635633
67	MP0005253_abnormal_eye_physiology	0.97203723
68	MP0001286_abnormal_eye_development	0.97171798
69	MP0001905_abnormal_dopamine_level	0.96796289
70	MP0000647_abnormal_sebaceous_gland	0.93898321
71	MP0003567_abnormal_fetal_cardiomyocyte	0.93712968
72	MP0003635_abnormal_synaptic_transmissio	0.91540861
73	MP0002184_abnormal_innervation	0.89983456
74	MP0002572_abnormal_emotion/affect_behav	0.89856685
75	MP0009780_abnormal_chondrocyte_physiolo	0.86895746
76	MP0004043_abnormal_pH_regulation	0.86785521
77	MP0002734_abnormal_mechanical_nocicepti	0.86047342
78	MP0005423_abnormal_somatic_nervous	0.84123098
79	MP0001963_abnormal_hearing_physiology	0.84120811
80	MP0002876_abnormal_thyroid_physiology	0.84060962
81	MP0002822_catalepsy	0.83949647
82	MP0002254_reproductive_system_inflammat	0.82828243
83	MP0002064_seizures	0.82118964
84	MP0002882_abnormal_neuron_morphology	0.81599184
85	MP0001529_abnormal_vocalization	0.81110284
86	MP0002063_abnormal_learning/memory/cond	0.80969799
87	MP0004019_abnormal_vitamin_homeostasis	0.79925065
88	MP0002095_abnormal_skin_pigmentation	0.79907577
89	MP0002210_abnormal_sex_determination	0.78639530
90	MP0001502_abnormal_circadian_rhythm	0.77492180
91	MP0005389_reproductive_system_phenotype	0.77150144
92	MP0002928_abnormal_bile_duct	0.75244727
93	MP0002067_abnormal_sensory_capabilities	0.72680927
94	MP0003879_abnormal_hair_cell	0.70251699
95	MP0002090_abnormal_vision	0.69544850
96	MP0003942_abnormal_urinary_system	0.68899648
97	MP0002733_abnormal_thermal_nociception	0.68873953
98	MP0000569_abnormal_digit_pigmentation	0.66408951
99	MP0003861_abnormal_nervous_system	0.66204397
100	MP0001542_abnormal_bone_strength	0.65262415

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	4.34435400
2	Pancreatic fibrosis (HP:0100732)	4.20674139
3	Acute necrotizing encephalopathy (HP:0006965)	3.79950652
4	Medial flaring of the eyebrow (HP:0010747)	3.73275291
5	Reticulocytopenia (HP:0001896)	3.55903467
6	Abnormality of midbrain morphology (HP:0002418)	3.52492221
7	Molar tooth sign on MRI (HP:0002419)	3.52492221
8	True hermaphroditism (HP:0010459)	3.37011963
9	Gait imbalance (HP:0002141)	3.31438087
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.25020265
11	Chronic hepatic failure (HP:0100626)	3.23897583
12	Pancreatic cysts (HP:0001737)	3.20815313
13	Acute encephalopathy (HP:0006846)	3.19186334
14	Nephronophthisis (HP:0000090)	3.16669295
15	Abnormal rod and cone electroretinograms (HP:0008323)	3.14133536
16	Progressive macrocephaly (HP:0004481)	3.13632101
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12602505
18	Congenital primary aphakia (HP:0007707)	3.03483412
19	Mitochondrial inheritance (HP:0001427)	3.02386911
20	Rib fusion (HP:0000902)	2.85285049
21	Sclerocornea (HP:0000647)	2.85038233
22	Abnormality of the renal medulla (HP:0100957)	2.82662245
23	Nephrogenic diabetes insipidus (HP:0009806)	2.78907247
24	Agitation (HP:0000713)	2.78881542
25	Colon cancer (HP:0003003)	2.78463433
26	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.78387151
27	Increased CSF lactate (HP:0002490)	2.76901302
28	Congenital stationary night blindness (HP:0007642)	2.66124330
29	Enlarged penis (HP:0000040)	2.65470611
30	Hyperthyroidism (HP:0000836)	2.65355657
31	Oligodactyly (hands) (HP:0001180)	2.63246256
32	Abnormality of cells of the erythroid lineage (HP:0012130)	2.59951454
33	Febrile seizures (HP:0002373)	2.58606446
34	Stenosis of the external auditory canal (HP:0000402)	2.58463075
35	Optic nerve hypoplasia (HP:0000609)	2.57099959
36	Poor suck (HP:0002033)	2.56490666
37	Absent septum pellucidum (HP:0001331)	2.56223164
38	Macrocytic anemia (HP:0001972)	2.52016975
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.51855496
40	Anencephaly (HP:0002323)	2.51373008
41	Asplenia (HP:0001746)	2.50643298
42	Myokymia (HP:0002411)	2.50080380
43	Growth hormone deficiency (HP:0000824)	2.49295451
44	Adrenal hypoplasia (HP:0000835)	2.48626641
45	Poor coordination (HP:0002370)	2.45455548
46	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.41292089
47	Abnormal pancreas size (HP:0012094)	2.36360365
48	Polyphagia (HP:0002591)	2.36127067
49	Vaginal atresia (HP:0000148)	2.34132730
50	Abolished electroretinogram (ERG) (HP:0000550)	2.32066359
51	Abnormality of the labia minora (HP:0012880)	2.31238938
52	Genital tract atresia (HP:0001827)	2.25033577
53	Hepatocellular necrosis (HP:0001404)	2.23699904
54	Cerebral edema (HP:0002181)	2.22733790
55	Abnormality of abdominal situs (HP:0011620)	2.22701542
56	Abdominal situs inversus (HP:0003363)	2.22701542
57	Hypogonadotrophic hypogonadism (HP:0000044)	2.19194720
58	Male pseudohermaphroditism (HP:0000037)	2.19137025
59	Congenital hepatic fibrosis (HP:0002612)	2.18118269
60	Oligodactyly (HP:0012165)	2.17390829
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.17157662
62	Abnormality of the renal cortex (HP:0011035)	2.16556895
63	Maternal diabetes (HP:0009800)	2.13092858
64	Cystic liver disease (HP:0006706)	2.12257297
65	Anosmia (HP:0000458)	2.10993418
66	Left ventricular hypertrophy (HP:0001712)	2.10660836
67	Hip dysplasia (HP:0001385)	2.10482552
68	Pendular nystagmus (HP:0012043)	2.10025134
69	Limb dystonia (HP:0002451)	2.04195296
70	Neoplasm of the adrenal cortex (HP:0100641)	2.02628034
71	Keratoconus (HP:0000563)	1.99810313
72	Increased corneal curvature (HP:0100692)	1.99810313
73	Diastasis recti (HP:0001540)	1.98954519
74	Lissencephaly (HP:0001339)	1.94721484
75	Anophthalmia (HP:0000528)	1.94637392
76	Abnormality of the corticospinal tract (HP:0002492)	1.94257945
77	Postaxial foot polydactyly (HP:0001830)	1.92858910
78	Tubular atrophy (HP:0000092)	1.92635774
79	Optic disc pallor (HP:0000543)	1.92620377
80	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.91264184
81	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.91264184
82	Specific learning disability (HP:0001328)	1.88778858
83	Postaxial hand polydactyly (HP:0001162)	1.87601222
84	Abnormal number of incisors (HP:0011064)	1.87101756
85	Narrow forehead (HP:0000341)	1.84883163
86	Lipid accumulation in hepatocytes (HP:0006561)	1.81650362
87	Hepatoblastoma (HP:0002884)	1.80796249
88	Shawl scrotum (HP:0000049)	1.80075681
89	Astigmatism (HP:0000483)	1.79891443
90	Polydipsia (HP:0001959)	1.78486568
91	Abnormal drinking behavior (HP:0030082)	1.78486568
92	Preaxial hand polydactyly (HP:0001177)	1.78124825
93	Small hand (HP:0200055)	1.77826736
94	Abnormal eating behavior (HP:0100738)	1.77633902
95	Increased hepatocellular lipid droplets (HP:0006565)	1.75328505
96	CNS hypomyelination (HP:0003429)	1.75210984
97	Hepatic necrosis (HP:0002605)	1.74637436
98	Aganglionic megacolon (HP:0002251)	1.74606203
99	Abnormality of the metopic suture (HP:0005556)	1.72737705
100	Absent thumb (HP:0009777)	1.71294877

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK39	4.04134874
2	MAP3K12	3.57694360
3	CASK	3.46601086
4	STK16	3.05634721
5	OXSR1	2.80464650
6	FRK	2.73600739
7	PAK3	2.61935734
8	TNIK	2.61601247
9	MST4	2.28873414
10	DYRK2	2.21215866
11	MAPK13	1.94222886
12	LIMK1	1.91114627
13	WNK4	1.79568117
14	BMPR1B	1.78931828
15	MARK1	1.64425225
16	WNK3	1.57359377
17	NUAK1	1.54932059
18	GRK1	1.51968851
19	MAP4K2	1.50440504
20	MAP2K7	1.47058038
21	PRKCG	1.45739547
22	EIF2AK3	1.40203325
23	DMPK	1.40087863
24	MYLK	1.39590369
25	NEK1	1.34194310
26	MKNK2	1.34045327
27	STK3	1.30054689
28	ILK	1.23664600
29	PRKCI	1.21876018
30	GRK7	1.20648884
31	PINK1	1.20344337
32	PIK3CA	1.19932205
33	LRRK2	1.18226553
34	PLK4	1.09187855
35	CDK19	1.09075297
36	PHKG2	1.07895599
37	PHKG1	1.07895599
38	MINK1	1.07555133
39	ADRBK1	1.04976137
40	DAPK3	1.01848257
41	PRKCE	0.96217137
42	MAP3K4	0.96090969
43	BRSK2	0.93933523
44	PRKCQ	0.93687219
45	EPHB2	0.91329103
46	NTRK2	0.87016517
47	ADRBK2	0.86023508
48	EPHA4	0.85182197
49	STK38L	0.84685396
50	SGK223	0.81384998
51	SGK494	0.81384998
52	MAP2K4	0.76915530
53	STK11	0.75232387
54	CAMK1	0.74580822
55	TRIM28	0.74444117
56	ACVR1B	0.73364075
57	BRSK1	0.71919170
58	PLK2	0.71253735
59	CSNK1G2	0.70452855
60	CAMKK2	0.68955792
61	FER	0.66053361
62	PDK2	0.65246572
63	ABL2	0.64415148
64	CAMK1D	0.64412516
65	PKN1	0.64263059
66	ROCK1	0.62746547
67	ZAK	0.62329192
68	PRKCZ	0.62214608
69	PRKACA	0.61500173
70	INSRR	0.59268321
71	CHEK2	0.58960568
72	CAMK2D	0.58026667
73	PLK3	0.57724311
74	CAMK1G	0.52404797
75	PRKG1	0.50647874
76	GRK5	0.49713719
77	SGK2	0.49595602
78	CSNK2A2	0.49118448
79	SGK1	0.49018701
80	TGFBR1	0.48956765
81	CAMK2A	0.47394058
82	PLK1	0.46417253
83	CAMK4	0.44194918
84	BCR	0.43197337
85	CSNK1E	0.42960831
86	DAPK1	0.42454451
87	TYRO3	0.41650114
88	STK38	0.41311715
89	CSNK1A1	0.40623208
90	TIE1	0.40530842
91	ROCK2	0.40403907
92	OBSCN	0.40207691
93	CAMK2G	0.38575572
94	PNCK	0.38430994
95	BCKDK	0.38403378
96	AKT3	0.38336110
97	PAK1	0.37824257
98	PIK3CG	0.36306264
99	PRKD3	0.36227300
100	PRKACB	0.35216698

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.51927951
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.13936004
3	Parkinsons disease_Homo sapiens_hsa05012	3.45421820
4	Protein export_Homo sapiens_hsa03060	2.60969802
5	Phototransduction_Homo sapiens_hsa04744	2.59103624
6	Huntingtons disease_Homo sapiens_hsa05016	2.52922527
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.44917774
8	Alzheimers disease_Homo sapiens_hsa05010	2.42913837
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.38852116
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.37898041
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.21872201
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.94974256
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81938945
14	Butanoate metabolism_Homo sapiens_hsa00650	1.78469181
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.78258056
16	Nicotine addiction_Homo sapiens_hsa05033	1.77867685
17	Sulfur relay system_Homo sapiens_hsa04122	1.70627030
18	One carbon pool by folate_Homo sapiens_hsa00670	1.62587292
19	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.54588001
20	Caffeine metabolism_Homo sapiens_hsa00232	1.49407043
21	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47155127
22	RNA polymerase_Homo sapiens_hsa03020	1.44222752
23	Steroid biosynthesis_Homo sapiens_hsa00100	1.37559949
24	Olfactory transduction_Homo sapiens_hsa04740	1.27663247
25	Glutathione metabolism_Homo sapiens_hsa00480	1.19720890
26	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.16864558
27	Homologous recombination_Homo sapiens_hsa03440	1.16707330
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.15322547
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.14779791
30	Insulin secretion_Homo sapiens_hsa04911	1.13943813
31	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.13535487
32	Basal cell carcinoma_Homo sapiens_hsa05217	1.12593936
33	Peroxisome_Homo sapiens_hsa04146	1.11618210
34	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.11253772
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.10581229
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.07703652
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.06176115
38	Folate biosynthesis_Homo sapiens_hsa00790	1.03433680
39	Proteasome_Homo sapiens_hsa03050	1.03338634
40	Basal transcription factors_Homo sapiens_hsa03022	1.03296905
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00722556
42	Propanoate metabolism_Homo sapiens_hsa00640	1.00126115
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.97644964
44	Morphine addiction_Homo sapiens_hsa05032	0.95027644
45	RNA degradation_Homo sapiens_hsa03018	0.94804145
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.93094851
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.92546037
48	Fatty acid elongation_Homo sapiens_hsa00062	0.88754026
49	GABAergic synapse_Homo sapiens_hsa04727	0.79822629
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79377516
51	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.78304732
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.78177374
53	Fatty acid degradation_Homo sapiens_hsa00071	0.77921896
54	Selenocompound metabolism_Homo sapiens_hsa00450	0.77502493
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.75717270
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73605114
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72789792
58	Ether lipid metabolism_Homo sapiens_hsa00565	0.71438537
59	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.70760941
60	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.68686021
61	Metabolic pathways_Homo sapiens_hsa01100	0.68558900
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65795044
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.65288700
64	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.64328134
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64123421
66	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.63908597
67	Retinol metabolism_Homo sapiens_hsa00830	0.62981357
68	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.61989148
69	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.61913773
70	p53 signaling pathway_Homo sapiens_hsa04115	0.61227836
71	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.60997458
72	Dopaminergic synapse_Homo sapiens_hsa04728	0.60494512
73	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.59432459
74	Pyruvate metabolism_Homo sapiens_hsa00620	0.58008053
75	Hippo signaling pathway_Homo sapiens_hsa04390	0.55393004
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.55322433
77	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.54787482
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54511666
79	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53588168
80	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.52348105
81	Purine metabolism_Homo sapiens_hsa00230	0.51544697
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.50082531
83	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.49120648
84	Axon guidance_Homo sapiens_hsa04360	0.49095398
85	Pyrimidine metabolism_Homo sapiens_hsa00240	0.48051472
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.47893034
87	Asthma_Homo sapiens_hsa05310	0.46807990
88	Circadian entrainment_Homo sapiens_hsa04713	0.46025721
89	Salivary secretion_Homo sapiens_hsa04970	0.44930172
90	Cocaine addiction_Homo sapiens_hsa05030	0.44449352
91	Melanoma_Homo sapiens_hsa05218	0.43139310
92	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.35387522
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.34807101
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.33224768
95	Gastric acid secretion_Homo sapiens_hsa04971	0.31244122
96	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30977005
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.30447096
98	Melanogenesis_Homo sapiens_hsa04916	0.29894032
99	Serotonergic synapse_Homo sapiens_hsa04726	0.29532686
100	Amphetamine addiction_Homo sapiens_hsa05031	0.29471418

RPL36AP33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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