RPL36AP39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)8.95955606
2ribosomal small subunit biogenesis (GO:0042274)8.75718292
3translational termination (GO:0006415)8.57339657
4ribosomal small subunit assembly (GO:0000028)7.89598286
5maturation of SSU-rRNA (GO:0030490)7.44323946
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.08065276
7cotranslational protein targeting to membrane (GO:0006613)6.98069148
8translational elongation (GO:0006414)6.95775107
9protein targeting to ER (GO:0045047)6.95220879
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.67803829
11protein localization to endoplasmic reticulum (GO:0070972)6.55839288
12cellular protein complex disassembly (GO:0043624)6.54671810
13viral life cycle (GO:0019058)6.45895730
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.38881299
15protein complex disassembly (GO:0043241)5.64428984
16translational initiation (GO:0006413)5.36605484
17macromolecular complex disassembly (GO:0032984)5.34310552
18behavioral response to nicotine (GO:0035095)5.17666829
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.88113293
20ATP synthesis coupled proton transport (GO:0015986)4.88113293
21protein targeting to membrane (GO:0006612)4.82125368
22ribosomal large subunit biogenesis (GO:0042273)4.81591064
23chaperone-mediated protein transport (GO:0072321)4.78217798
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.78095346
25substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.76519196
26substrate-independent telencephalic tangential migration (GO:0021826)4.76519196
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.36559027
28pattern specification involved in kidney development (GO:0061004)4.18041390
29mitochondrial respiratory chain complex I assembly (GO:0032981)4.16277570
30NADH dehydrogenase complex assembly (GO:0010257)4.16277570
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.16277570
32mRNA catabolic process (GO:0006402)4.12972904
33tongue development (GO:0043586)4.09382369
34mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.06644122
35translation (GO:0006412)4.06622635
36protein neddylation (GO:0045116)4.05409570
37cell proliferation in forebrain (GO:0021846)4.00752030
38ribonucleoprotein complex biogenesis (GO:0022613)3.99311663
39protein complex biogenesis (GO:0070271)3.96346450
40mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92449422
41cellular component biogenesis (GO:0044085)3.84127535
42epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.83762269
43nonmotile primary cilium assembly (GO:0035058)3.80147332
44RNA catabolic process (GO:0006401)3.71326844
45hypothalamus development (GO:0021854)3.64476408
46mitochondrial respiratory chain complex assembly (GO:0033108)3.59164202
47respiratory electron transport chain (GO:0022904)3.54243785
48electron transport chain (GO:0022900)3.53708189
49neuron fate determination (GO:0048664)3.38255134
50establishment of protein localization to membrane (GO:0090150)3.36428934
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.34735895
52somite development (GO:0061053)3.34299218
53segment specification (GO:0007379)3.31671008
54negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.29655188
55axon ensheathment in central nervous system (GO:0032291)3.27658383
56central nervous system myelination (GO:0022010)3.27658383
57GTP biosynthetic process (GO:0006183)3.25732893
58pyrimidine nucleotide catabolic process (GO:0006244)3.18807522
59protein targeting (GO:0006605)3.15848027
60cardiovascular system development (GO:0072358)3.14184178
61auditory receptor cell differentiation (GO:0042491)3.11272455
62regulation of cilium movement (GO:0003352)3.06380549
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.99202827
64epithelial cilium movement (GO:0003351)2.98140198
65establishment of protein localization to organelle (GO:0072594)2.94167821
66Sertoli cell development (GO:0060009)2.93982921
67synaptic transmission, cholinergic (GO:0007271)2.92912634
68ATP biosynthetic process (GO:0006754)2.90824911
69purine nucleoside triphosphate biosynthetic process (GO:0009145)2.90540309
70tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.86815972
71RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.86815972
72intraciliary transport (GO:0042073)2.82617993
73negative regulation of response to food (GO:0032096)2.81989482
74negative regulation of appetite (GO:0032099)2.81989482
75nephron epithelium morphogenesis (GO:0072088)2.80367187
76nephron tubule morphogenesis (GO:0072078)2.80367187
77pyrimidine nucleobase catabolic process (GO:0006208)2.77795375
78UTP biosynthetic process (GO:0006228)2.77521840
79water-soluble vitamin biosynthetic process (GO:0042364)2.75670924
80regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.75302858
81positive regulation of T cell apoptotic process (GO:0070234)2.73952587
82neuronal stem cell maintenance (GO:0097150)2.73586688
83protein localization to membrane (GO:0072657)2.71469600
84UTP metabolic process (GO:0046051)2.68809858
85telencephalon development (GO:0021537)2.68024442
86positive regulation of respiratory burst (GO:0060267)2.67927742
87ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65784681
88meiotic chromosome segregation (GO:0045132)2.65703999
89hydrogen ion transmembrane transport (GO:1902600)2.63186050
90short-term memory (GO:0007614)2.58095741
91negative regulation of DNA-templated transcription, elongation (GO:0032785)2.57280840
92rRNA processing (GO:0006364)2.56893345
93intracellular protein transmembrane import (GO:0044743)2.54533649
94rRNA metabolic process (GO:0016072)2.54059225
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50865587
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.49205362
97cilium movement (GO:0003341)2.48782493
98head development (GO:0060322)2.48236418
99cerebral cortex radially oriented cell migration (GO:0021799)2.47704078
100axonemal dynein complex assembly (GO:0070286)2.45466413

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.22365777
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.21896526
3GABP_17652178_ChIP-ChIP_JURKAT_Human2.68073692
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.65479230
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.43364173
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36405541
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31612803
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24942053
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.05238992
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.02250588
11EZH2_27294783_Chip-Seq_ESCs_Mouse1.94834119
12MYC_18555785_ChIP-Seq_MESCs_Mouse1.89897756
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.86009188
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82134447
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.81536857
16EST1_17652178_ChIP-ChIP_JURKAT_Human1.80312285
17ZNF274_21170338_ChIP-Seq_K562_Hela1.80022907
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79286072
19IRF1_19129219_ChIP-ChIP_H3396_Human1.78389099
20VDR_22108803_ChIP-Seq_LS180_Human1.77483184
21SUZ12_27294783_Chip-Seq_ESCs_Mouse1.73153586
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.65707551
23REST_21632747_ChIP-Seq_MESCs_Mouse1.63805130
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62958019
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.62424232
26GATA1_26923725_Chip-Seq_HPCs_Mouse1.60762971
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.58089123
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56503417
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.50445969
30TTF2_22483619_ChIP-Seq_HELA_Human1.44418767
31CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41784667
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.41253427
33XRN2_22483619_ChIP-Seq_HELA_Human1.39991047
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39803313
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39803313
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39735740
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.38813065
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37992811
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36563726
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35609080
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34237195
42CTCF_27219007_Chip-Seq_Bcells_Human1.33254715
43CTCF_18555785_ChIP-Seq_MESCs_Mouse1.29918823
44GABP_19822575_ChIP-Seq_HepG2_Human1.29820832
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.28541025
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27299448
47MYC_18940864_ChIP-ChIP_HL60_Human1.27186270
48ETV2_25802403_ChIP-Seq_MESCs_Mouse1.24267370
49GATA3_21878914_ChIP-Seq_MCF-7_Human1.20540436
50SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.20495233
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.20377235
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.19025165
53CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18930407
54ERA_21632823_ChIP-Seq_H3396_Human1.17512622
55RNF2_27304074_Chip-Seq_NSC_Mouse1.16389727
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15817129
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15330921
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.14397253
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14254600
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.13206346
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.12872800
62SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11741875
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10150532
64OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08782028
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08100748
66SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08095010
67EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07272059
68TAF2_19829295_ChIP-Seq_ESCs_Human1.04491630
69TP53_22573176_ChIP-Seq_HFKS_Human1.03552210
70SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03511600
71NANOG_20526341_ChIP-Seq_ESCs_Human0.99832573
72RING1B_27294783_Chip-Seq_ESCs_Mouse0.99243572
73NCOR_22424771_ChIP-Seq_293T_Human0.99013462
74YY1_22570637_ChIP-Seq_MALME-3M_Human0.98638771
75SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.98226899
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.96351696
77RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96204938
78CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95385390
79RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.95004865
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94099739
81FOXP1_21924763_ChIP-Seq_HESCs_Human0.91174681
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91054251
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91035151
84P68_20966046_ChIP-Seq_HELA_Human0.90882448
85ELK1_19687146_ChIP-ChIP_HELA_Human0.90030736
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89958687
87E2F1_17053090_ChIP-ChIP_MCF-7_Human0.89285225
88P53_21459846_ChIP-Seq_SAOS-2_Human0.88990633
89MYC_19829295_ChIP-Seq_ESCs_Human0.88074708
90VDR_23849224_ChIP-Seq_CD4+_Human0.86093945
91NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86052285
92FOXH1_21741376_ChIP-Seq_EPCs_Human0.85544905
93BCL6_27268052_Chip-Seq_Bcells_Human0.85329473
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84709876
95E2F1_20622854_ChIP-Seq_HELA_Human0.83901970
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.83883860
97CTCF_20526341_ChIP-Seq_ESCs_Human0.83523205
98WDR5_24793694_ChIP-Seq_LNCAP_Human0.83212807
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82435751
100SRY_22984422_ChIP-ChIP_TESTIS_Rat0.81448708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.91323690
2MP0006292_abnormal_olfactory_placode5.23410680
3MP0003787_abnormal_imprinting3.75917596
4MP0003123_paternal_imprinting2.95681710
5MP0003122_maternal_imprinting2.88808062
6MP0008789_abnormal_olfactory_epithelium2.84417472
7MP0002653_abnormal_ependyma_morphology2.74811668
8MP0003121_genomic_imprinting2.48626447
9MP0002163_abnormal_gland_morphology2.41891540
10MP0005499_abnormal_olfactory_system2.36978177
11MP0005394_taste/olfaction_phenotype2.36978177
12MP0008877_abnormal_DNA_methylation2.09324333
13MP0010030_abnormal_orbit_morphology2.09080598
14MP0001293_anophthalmia1.96719321
15MP0000049_abnormal_middle_ear1.89422877
16MP0004142_abnormal_muscle_tone1.89035276
17MP0003136_yellow_coat_color1.86945805
18MP0000566_synostosis1.86302945
19MP0005646_abnormal_pituitary_gland1.83270370
20MP0000778_abnormal_nervous_system1.82484674
21MP0003878_abnormal_ear_physiology1.80589573
22MP0005377_hearing/vestibular/ear_phenot1.80589573
23MP0006276_abnormal_autonomic_nervous1.76386747
24MP0001984_abnormal_olfaction1.74853920
25MP0003880_abnormal_central_pattern1.58507884
26MP0002837_dystrophic_cardiac_calcinosis1.54828697
27MP0004133_heterotaxia1.52981548
28MP0004885_abnormal_endolymph1.47748585
29MP0001529_abnormal_vocalization1.46072122
30MP0000631_abnormal_neuroendocrine_gland1.45504902
31MP0005379_endocrine/exocrine_gland_phen1.44248284
32MP0002234_abnormal_pharynx_morphology1.42976337
33MP0001968_abnormal_touch/_nociception1.40013371
34MP0002233_abnormal_nose_morphology1.33253351
35MP0001485_abnormal_pinna_reflex1.32439787
36MP0009053_abnormal_anal_canal1.28272327
37MP0002272_abnormal_nervous_system1.27044525
38MP0002938_white_spotting1.25804439
39MP0005195_abnormal_posterior_eye1.22463016
40MP0001905_abnormal_dopamine_level1.21174071
41MP0006072_abnormal_retinal_apoptosis1.20960695
42MP0003938_abnormal_ear_development1.17632730
43MP0000026_abnormal_inner_ear1.16283797
44MP0002736_abnormal_nociception_after1.15912260
45MP0003183_abnormal_peptide_metabolism1.15187782
46MP0003646_muscle_fatigue1.15164744
47MP0002638_abnormal_pupillary_reflex1.12590284
48MP0005423_abnormal_somatic_nervous1.12584121
49MP0005551_abnormal_eye_electrophysiolog1.11920422
50MP0003315_abnormal_perineum_morphology1.11908703
51MP0002184_abnormal_innervation1.08978423
52MP0000955_abnormal_spinal_cord1.08566450
53MP0002095_abnormal_skin_pigmentation1.05812055
54MP0002752_abnormal_somatic_nervous1.04158436
55MP0001970_abnormal_pain_threshold1.04031555
56MP0002733_abnormal_thermal_nociception1.03614313
57MP0003937_abnormal_limbs/digits/tail_de1.02487839
58MP0003635_abnormal_synaptic_transmissio1.02463559
59MP0002557_abnormal_social/conspecific_i1.01571234
60MP0001348_abnormal_lacrimal_gland0.99214400
61MP0002063_abnormal_learning/memory/cond0.98900532
62MP0009745_abnormal_behavioral_response0.98754933
63MP0002572_abnormal_emotion/affect_behav0.96906626
64MP0000613_abnormal_salivary_gland0.95116612
65MP0001286_abnormal_eye_development0.94607531
66MP0003186_abnormal_redox_activity0.93853278
67MP0001440_abnormal_grooming_behavior0.93400023
68MP0008872_abnormal_physiological_respon0.92270820
69MP0002876_abnormal_thyroid_physiology0.92193600
70MP0000372_irregular_coat_pigmentation0.92156141
71MP0003011_delayed_dark_adaptation0.91184523
72MP0003755_abnormal_palate_morphology0.88258177
73MP0002102_abnormal_ear_morphology0.87892503
74MP0003942_abnormal_urinary_system0.87561385
75MP0003879_abnormal_hair_cell0.85007761
76MP0002734_abnormal_mechanical_nocicepti0.83485351
77MP0001963_abnormal_hearing_physiology0.82802678
78MP0002160_abnormal_reproductive_system0.82700056
79MP0002210_abnormal_sex_determination0.82458280
80MP0001486_abnormal_startle_reflex0.82403832
81MP0002249_abnormal_larynx_morphology0.82123918
82MP0004043_abnormal_pH_regulation0.80918564
83MP0005389_reproductive_system_phenotype0.80867315
84MP0004130_abnormal_muscle_cell0.80348041
85MP0005174_abnormal_tail_pigmentation0.80321801
86MP0005408_hypopigmentation0.79593728
87MP0004742_abnormal_vestibular_system0.79015083
88MP0009046_muscle_twitch0.77981510
89MP0004145_abnormal_muscle_electrophysio0.77503180
90MP0002882_abnormal_neuron_morphology0.77336560
91MP0001919_abnormal_reproductive_system0.76782526
92MP0004859_abnormal_synaptic_plasticity0.76517258
93MP0002152_abnormal_brain_morphology0.76216635
94MP0001188_hyperpigmentation0.74205707
95MP0003861_abnormal_nervous_system0.73218994
96MP0002064_seizures0.71374417
97MP0002067_abnormal_sensory_capabilities0.70999641
98MP0008875_abnormal_xenobiotic_pharmacok0.70491174
99MP0005391_vision/eye_phenotype0.69539515
100MP0002697_abnormal_eye_size0.68632429

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.23758892
2Abnormality of cells of the erythroid lineage (HP:0012130)5.08868548
3Macrocytic anemia (HP:0001972)4.23176392
4Septo-optic dysplasia (HP:0100842)3.82066969
5Acute necrotizing encephalopathy (HP:0006965)3.77809265
6Molar tooth sign on MRI (HP:0002419)3.63529309
7Abnormality of midbrain morphology (HP:0002418)3.63529309
8Pancreatic fibrosis (HP:0100732)3.53145800
9Abnormal number of erythroid precursors (HP:0012131)3.52082270
10Medial flaring of the eyebrow (HP:0010747)3.47645953
11Pallor (HP:0000980)3.38135784
12Absent rod-and cone-mediated responses on ERG (HP:0007688)3.34698222
13Abnormal mitochondria in muscle tissue (HP:0008316)3.31633130
14Acute encephalopathy (HP:0006846)3.29542187
15Rib fusion (HP:0000902)3.20483963
16Pancreatic cysts (HP:0001737)3.11451054
17Gait imbalance (HP:0002141)3.11103398
18Nonprogressive disorder (HP:0003680)3.10809221
19Mitochondrial inheritance (HP:0001427)3.07648473
20Type II lissencephaly (HP:0007260)3.00154855
21Congenital primary aphakia (HP:0007707)2.93426961
22Absent thumb (HP:0009777)2.87508591
23Progressive macrocephaly (HP:0004481)2.86165936
24Stenosis of the external auditory canal (HP:0000402)2.85893499
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.83194485
26Abnormal rod and cone electroretinograms (HP:0008323)2.80509462
273-Methylglutaconic aciduria (HP:0003535)2.78239381
28Nephrogenic diabetes insipidus (HP:0009806)2.78116750
29True hermaphroditism (HP:0010459)2.65854750
30Increased CSF lactate (HP:0002490)2.62559364
31Hypoplasia of the radius (HP:0002984)2.61169546
32Asplenia (HP:0001746)2.52609074
33Aplasia/Hypoplasia of the spleen (HP:0010451)2.51920133
34Sclerocornea (HP:0000647)2.48602736
35Partial duplication of thumb phalanx (HP:0009944)2.46319519
36Anophthalmia (HP:0000528)2.46190877
37Depressed nasal ridge (HP:0000457)2.45737912
38Lipid accumulation in hepatocytes (HP:0006561)2.41362324
39Cystic liver disease (HP:0006706)2.38945426
40Poor coordination (HP:0002370)2.37915214
41Oligodactyly (HP:0012165)2.36829718
42Absent septum pellucidum (HP:0001331)2.34457188
43Cerebral edema (HP:0002181)2.33987946
44Maternal diabetes (HP:0009800)2.31930408
45Oligodactyly (hands) (HP:0001180)2.31049980
46Colon cancer (HP:0003003)2.26042908
47Increased hepatocellular lipid droplets (HP:0006565)2.26023913
48Hepatocellular necrosis (HP:0001404)2.21625788
49Forearm undergrowth (HP:0009821)2.20088535
50Nephronophthisis (HP:0000090)2.18553416
51Adrenal hypoplasia (HP:0000835)2.17569222
52Vaginal atresia (HP:0000148)2.16697950
53Myokymia (HP:0002411)2.14710355
54Congenital stationary night blindness (HP:0007642)2.13841010
55Anencephaly (HP:0002323)2.13130556
56Abnormality of the labia minora (HP:0012880)2.06624747
57Genital tract atresia (HP:0001827)2.06413304
58Abnormality of the diencephalon (HP:0010662)2.06333973
5911 pairs of ribs (HP:0000878)2.05064076
60Renal Fanconi syndrome (HP:0001994)2.03675165
61Supernumerary spleens (HP:0009799)2.03630822
62Optic nerve hypoplasia (HP:0000609)2.02323488
63Chronic hepatic failure (HP:0100626)2.01406120
64Hypoplasia of the ulna (HP:0003022)2.00925148
65Postaxial foot polydactyly (HP:0001830)2.00471088
66Lissencephaly (HP:0001339)1.98881143
67Optic disc pallor (HP:0000543)1.98193969
68Hepatic necrosis (HP:0002605)1.97952799
69Hyperglycinemia (HP:0002154)1.97611679
70Hip dysplasia (HP:0001385)1.96097979
71Partial duplication of the phalanx of hand (HP:0009999)1.95725644
72Growth hormone deficiency (HP:0000824)1.94529590
73Abnormal biliary tract physiology (HP:0012439)1.91377654
74Bile duct proliferation (HP:0001408)1.91377654
75Abnormal drinking behavior (HP:0030082)1.90968334
76Polydipsia (HP:0001959)1.90968334
77Hyperthyroidism (HP:0000836)1.88711748
78Cerebellar dysplasia (HP:0007033)1.87865603
79Increased intramyocellular lipid droplets (HP:0012240)1.86955776
80Pendular nystagmus (HP:0012043)1.86929710
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.85950788
82Pachygyria (HP:0001302)1.85806024
83Abnormal hemoglobin (HP:0011902)1.84736422
84Triphalangeal thumb (HP:0001199)1.84250051
85Abnormality of the renal medulla (HP:0100957)1.83933908
86Abnormality of the aortic arch (HP:0012303)1.81039726
87Holoprosencephaly (HP:0001360)1.80049074
88Postaxial hand polydactyly (HP:0001162)1.76316647
89Aplasia/Hypoplasia of the tongue (HP:0010295)1.75704243
90Abnormal hair whorl (HP:0010721)1.75601546
91Increased muscle lipid content (HP:0009058)1.73968459
92Tubular atrophy (HP:0000092)1.72628155
93Anomalous pulmonary venous return (HP:0010772)1.72480859
94Microretrognathia (HP:0000308)1.71103911
95Horseshoe kidney (HP:0000085)1.71031970
96Aganglionic megacolon (HP:0002251)1.70288259
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.69768782
98Parakeratosis (HP:0001036)1.68284216
99Abnormal ciliary motility (HP:0012262)1.68208791
100Abnormal number of incisors (HP:0011064)1.66456107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.27816516
2CDK193.12693214
3EPHB23.01174942
4DYRK22.83565560
5STK162.50444726
6PIK3CA2.38536823
7LRRK22.32522701
8ADRBK22.25483934
9CASK2.20359925
10WNK32.04147254
11PINK11.95888213
12BMPR1B1.86248905
13BCKDK1.83777645
14GRK11.77892658
15TYRO31.76647914
16CAMK1D1.73488149
17NTRK21.71762549
18MAP3K41.67708974
19MAP2K71.59722433
20MAP3K111.58951814
21CDC71.53295530
22EPHA41.50383601
23LIMK11.44157304
24CAMK11.40147784
25DYRK1B1.38848214
26WNK11.37832170
27TLK11.36401539
28CAMK1G1.34912665
29PRKCG1.32068212
30MAP4K21.30076687
31CAMKK21.26215541
32NME21.25044824
33TIE11.22377115
34TNIK1.19915347
35STK391.17407533
36MARK11.16743736
37MAP2K41.14236128
38STK111.13588543
39ABL21.09613570
40PLK41.08214119
41BRAF1.05406537
42NUAK11.01249674
43MAP3K120.99341730
44ZAK0.96993643
45CAMKK10.96971008
46DAPK30.95317887
47NEK20.93920275
48FRK0.93270770
49ADRBK10.90965369
50MARK20.89207774
51SGK2230.88029699
52SGK4940.88029699
53AURKA0.86589739
54PHKG10.83176845
55PHKG20.83176845
56PRKCZ0.82717805
57TNK20.82697565
58CSNK2A20.78487461
59PAK30.77159190
60CDK80.76883651
61CHEK20.75719225
62AURKB0.75148417
63MUSK0.75080760
64MAPK130.73526140
65PRKCH0.72244722
66PTK60.71600815
67RPS6KA60.70489843
68PRKACA0.68047411
69PRKCI0.67921535
70PRKCQ0.67234133
71STK30.66706481
72CSNK1E0.66296690
73DMPK0.65753822
74PIM20.65413304
75PLK10.64539354
76SGK10.64426181
77MINK10.63758814
78OXSR10.61397022
79NTRK10.60118300
80CAMK40.59852716
81NEK10.56322756
82TRIM280.54915663
83TXK0.52709689
84DYRK30.50701720
85INSRR0.49987076
86CSNK1A10.49929475
87RPS6KC10.49170855
88RPS6KL10.49170855
89DAPK20.48412753
90CSNK2A10.48119661
91DYRK1A0.46622563
92AKT10.46474482
93PRKD30.45137751
94MAPK150.42815547
95PKN10.41139637
96CDK140.39395605
97MKNK20.39313247
98MAP3K90.38764547
99CDK11A0.37688600
100OBSCN0.36224639

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.81039480
2Oxidative phosphorylation_Homo sapiens_hsa001904.37865299
3Parkinsons disease_Homo sapiens_hsa050123.58475907
4Cardiac muscle contraction_Homo sapiens_hsa042602.92972789
5Huntingtons disease_Homo sapiens_hsa050162.76816850
6Alzheimers disease_Homo sapiens_hsa050102.52144864
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.44777341
8Sulfur relay system_Homo sapiens_hsa041222.31953929
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.29042686
10RNA polymerase_Homo sapiens_hsa030201.98513066
11Linoleic acid metabolism_Homo sapiens_hsa005911.95030162
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86274389
13alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.58883485
14Protein export_Homo sapiens_hsa030601.57602922
15Caffeine metabolism_Homo sapiens_hsa002321.55073466
16Homologous recombination_Homo sapiens_hsa034401.52151135
17Basal cell carcinoma_Homo sapiens_hsa052171.50399437
18Mismatch repair_Homo sapiens_hsa034301.49170127
19RNA degradation_Homo sapiens_hsa030181.43884231
20Nicotine addiction_Homo sapiens_hsa050331.41658424
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36736464
22DNA replication_Homo sapiens_hsa030301.29862403
23Phototransduction_Homo sapiens_hsa047441.25868944
24Pyrimidine metabolism_Homo sapiens_hsa002401.24803359
25Hedgehog signaling pathway_Homo sapiens_hsa043401.22799145
26Nucleotide excision repair_Homo sapiens_hsa034201.22481421
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21152072
28Fanconi anemia pathway_Homo sapiens_hsa034601.16496875
29One carbon pool by folate_Homo sapiens_hsa006701.12228346
30Basal transcription factors_Homo sapiens_hsa030221.12114278
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11172356
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09729421
33Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99597487
34Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.96007883
35Arachidonic acid metabolism_Homo sapiens_hsa005900.94963550
36Notch signaling pathway_Homo sapiens_hsa043300.93495134
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.89859536
38Steroid biosynthesis_Homo sapiens_hsa001000.89331705
39Fat digestion and absorption_Homo sapiens_hsa049750.87661858
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82888749
41Proteasome_Homo sapiens_hsa030500.82856073
42Ether lipid metabolism_Homo sapiens_hsa005650.77054068
43Propanoate metabolism_Homo sapiens_hsa006400.75896505
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75313798
45Butanoate metabolism_Homo sapiens_hsa006500.75298159
46Asthma_Homo sapiens_hsa053100.74334549
47Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73255954
48Metabolic pathways_Homo sapiens_hsa011000.72614208
49Tryptophan metabolism_Homo sapiens_hsa003800.72088955
50Chemical carcinogenesis_Homo sapiens_hsa052040.71692853
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.68770068
52Hippo signaling pathway_Homo sapiens_hsa043900.67892403
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.67047435
54Morphine addiction_Homo sapiens_hsa050320.65773135
55Base excision repair_Homo sapiens_hsa034100.65676158
56beta-Alanine metabolism_Homo sapiens_hsa004100.64625914
57Peroxisome_Homo sapiens_hsa041460.64502012
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62072995
59Olfactory transduction_Homo sapiens_hsa047400.61993077
60Purine metabolism_Homo sapiens_hsa002300.61970843
61Folate biosynthesis_Homo sapiens_hsa007900.61221081
62Axon guidance_Homo sapiens_hsa043600.60324715
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59431942
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.57624714
65Retinol metabolism_Homo sapiens_hsa008300.56587638
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.56296355
67RNA transport_Homo sapiens_hsa030130.56151770
68Spliceosome_Homo sapiens_hsa030400.55916305
69Collecting duct acid secretion_Homo sapiens_hsa049660.53333403
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50564874
71Nitrogen metabolism_Homo sapiens_hsa009100.50539589
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.50510083
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49920462
74Glycerolipid metabolism_Homo sapiens_hsa005610.48919466
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.48039016
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47734209
77Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45244875
78Glutamatergic synapse_Homo sapiens_hsa047240.43542767
79Insulin secretion_Homo sapiens_hsa049110.40625583
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.40294687
81Taste transduction_Homo sapiens_hsa047420.39664844
82Synaptic vesicle cycle_Homo sapiens_hsa047210.39036662
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.38902226
84Fatty acid degradation_Homo sapiens_hsa000710.38109478
85Wnt signaling pathway_Homo sapiens_hsa043100.37779978
86Pyruvate metabolism_Homo sapiens_hsa006200.37396226
87GABAergic synapse_Homo sapiens_hsa047270.35232511
88Regulation of autophagy_Homo sapiens_hsa041400.31656991
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30510056
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30131684
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.28588906
92Ovarian steroidogenesis_Homo sapiens_hsa049130.27411641
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27028529
94Serotonergic synapse_Homo sapiens_hsa047260.26320703
95Tyrosine metabolism_Homo sapiens_hsa003500.23040365
96Starch and sucrose metabolism_Homo sapiens_hsa005000.19142738
97Dopaminergic synapse_Homo sapiens_hsa047280.18477094
98Melanogenesis_Homo sapiens_hsa049160.17075865
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.17073383
100Ras signaling pathway_Homo sapiens_hsa040140.15492820

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