RPL36AP40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.25817439
2maturation of SSU-rRNA (GO:0030490)6.12712638
3regulation of immunoglobulin secretion (GO:0051023)5.85528502
4viral transcription (GO:0019083)5.53773489
5ribosomal small subunit assembly (GO:0000028)5.53623261
6translational termination (GO:0006415)5.39345312
7DNA deamination (GO:0045006)4.95991141
8regulation of isotype switching to IgG isotypes (GO:0048302)4.91734234
9nonmotile primary cilium assembly (GO:0035058)4.90183371
10chaperone-mediated protein transport (GO:0072321)4.76101064
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.73125136
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.68633829
13translational elongation (GO:0006414)4.66041332
14cotranslational protein targeting to membrane (GO:0006613)4.65582354
15protein targeting to ER (GO:0045047)4.62384478
16positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)4.49880679
17gamma-aminobutyric acid transport (GO:0015812)4.42748438
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.42743855
19behavioral response to nicotine (GO:0035095)4.41254968
20protein localization to endoplasmic reticulum (GO:0070972)4.34287994
21amine catabolic process (GO:0009310)4.23166065
22cellular biogenic amine catabolic process (GO:0042402)4.23166065
23substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.12945650
24substrate-independent telencephalic tangential migration (GO:0021826)4.12945650
25regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.05307074
26cellular protein complex disassembly (GO:0043624)4.00849572
27viral life cycle (GO:0019058)3.98735351
28CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.87935889
29GTP biosynthetic process (GO:0006183)3.77644226
30nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.74135617
31cardiovascular system development (GO:0072358)3.73969660
32ATP synthesis coupled proton transport (GO:0015986)3.65693773
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.65693773
34regulation of chronic inflammatory response (GO:0002676)3.60590047
35translational initiation (GO:0006413)3.59221987
36mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51321995
37water-soluble vitamin biosynthetic process (GO:0042364)3.46337691
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.35329447
39protein complex disassembly (GO:0043241)3.33605065
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.32137632
41UTP biosynthetic process (GO:0006228)3.29017115
42establishment of mitochondrion localization (GO:0051654)3.25734845
43negative regulation of telomere maintenance (GO:0032205)3.25633510
44macromolecular complex disassembly (GO:0032984)3.21891999
45translation (GO:0006412)3.20920985
46positive regulation of defense response to virus by host (GO:0002230)3.14277493
47interferon-gamma production (GO:0032609)3.09863081
48UTP metabolic process (GO:0046051)3.07793490
49establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.05735261
50mitochondrion transport along microtubule (GO:0047497)3.05735261
51protein targeting to membrane (GO:0006612)3.03218399
52regulation of cilium movement (GO:0003352)2.96276768
53ribosomal large subunit biogenesis (GO:0042273)2.92766626
54protein-cofactor linkage (GO:0018065)2.92264443
55positive regulation of T cell apoptotic process (GO:0070234)2.90622873
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.89723077
57glycine transport (GO:0015816)2.89477993
58ribonucleoprotein complex biogenesis (GO:0022613)2.88889163
59protein neddylation (GO:0045116)2.87744356
60protein complex biogenesis (GO:0070271)2.87129002
61head development (GO:0060322)2.87056117
62cellular component biogenesis (GO:0044085)2.85369573
63positive regulation of isotype switching (GO:0045830)2.85293229
64electron transport chain (GO:0022900)2.84505044
65cell proliferation in forebrain (GO:0021846)2.82848349
66regulation of podosome assembly (GO:0071801)2.79928433
67respiratory electron transport chain (GO:0022904)2.79305373
68somite development (GO:0061053)2.79145575
69mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.78316999
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.78316999
71NADH dehydrogenase complex assembly (GO:0010257)2.78316999
72axonal fasciculation (GO:0007413)2.76432860
73positive regulation of activated T cell proliferation (GO:0042104)2.72370336
74nuclear-transcribed mRNA catabolic process (GO:0000956)2.70464856
75positive regulation of DNA recombination (GO:0045911)2.67536276
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66960475
77negative regulation of T-helper cell differentiation (GO:0045623)2.65022081
78negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.65022081
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.62804795
80isotype switching (GO:0045190)2.62804795
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.62804795
82rRNA processing (GO:0006364)2.62443776
83negative regulation of DNA-templated transcription, elongation (GO:0032785)2.62127653
84genetic imprinting (GO:0071514)2.61920394
85positive regulation of immunoglobulin production (GO:0002639)2.61836400
86rRNA metabolic process (GO:0016072)2.60314782
87retinal rod cell development (GO:0046548)2.60118634
88preassembly of GPI anchor in ER membrane (GO:0016254)2.59906900
89CTP metabolic process (GO:0046036)2.59664886
90CTP biosynthetic process (GO:0006241)2.59664886
91L-fucose metabolic process (GO:0042354)2.58138891
92L-fucose catabolic process (GO:0042355)2.58138891
93fucose catabolic process (GO:0019317)2.58138891
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57966902
95epithelial cilium movement (GO:0003351)2.57874638
96alpha-beta T cell differentiation involved in immune response (GO:0002293)2.57231805
97alpha-beta T cell activation involved in immune response (GO:0002287)2.57231805
98T cell differentiation involved in immune response (GO:0002292)2.57231805
99male meiosis I (GO:0007141)2.57165917
100mRNA catabolic process (GO:0006402)2.57130500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.71363114
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.66602713
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.04447621
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.77883755
5VDR_22108803_ChIP-Seq_LS180_Human3.28029033
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73631413
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.69543127
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.60079328
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.39102862
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.21844624
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.16882662
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.07425341
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.01096807
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95298850
15BP1_19119308_ChIP-ChIP_Hs578T_Human1.92494823
16ZNF274_21170338_ChIP-Seq_K562_Hela1.91625176
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86837002
18IKZF1_21737484_ChIP-ChIP_HCT116_Human1.67483403
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66718698
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66257713
21EED_16625203_ChIP-ChIP_MESCs_Mouse1.62913545
22TP53_22573176_ChIP-Seq_HFKS_Human1.59441545
23REST_21632747_ChIP-Seq_MESCs_Mouse1.59414362
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.58628106
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.57634263
26TTF2_22483619_ChIP-Seq_HELA_Human1.55718943
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.52497825
28MYC_18940864_ChIP-ChIP_HL60_Human1.48637284
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.47502447
30VDR_23849224_ChIP-Seq_CD4+_Human1.45355484
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.44563699
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.43072358
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.42341768
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40912161
35GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37228936
36ERA_21632823_ChIP-Seq_H3396_Human1.37158196
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36933185
38ELK1_19687146_ChIP-ChIP_HELA_Human1.36927236
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33656947
40CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33158027
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32936021
42SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31393875
43PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.29319480
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29228385
45ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27986889
46NANOG_20526341_ChIP-Seq_ESCs_Human1.26698465
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25754764
48CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.25050246
49IRF1_19129219_ChIP-ChIP_H3396_Human1.23459877
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.17773609
51RNF2_27304074_Chip-Seq_NSC_Mouse1.17334939
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16463019
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.16297118
54NCOR_22424771_ChIP-Seq_293T_Human1.16003162
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.15902372
56JARID2_20075857_ChIP-Seq_MESCs_Mouse1.15296677
57EWS_26573619_Chip-Seq_HEK293_Human1.15263046
58SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.15034436
59TAF2_19829295_ChIP-Seq_ESCs_Human1.13734637
60MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13636156
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12546044
62CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12453316
63FOXP3_21729870_ChIP-Seq_TREG_Human1.11188827
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.10228914
65REST_18959480_ChIP-ChIP_MESCs_Mouse1.09099601
66GABP_19822575_ChIP-Seq_HepG2_Human1.08796499
67YY1_22570637_ChIP-Seq_MALME-3M_Human1.07040477
68GBX2_23144817_ChIP-Seq_PC3_Human1.06152587
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05739186
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.04999643
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04574936
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03767256
73RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02624415
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01083898
75AR_20517297_ChIP-Seq_VCAP_Human0.98937391
76RNF2_18974828_ChIP-Seq_MESCs_Mouse0.98695413
77EZH2_18974828_ChIP-Seq_MESCs_Mouse0.98695413
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97812936
79SRF_21415370_ChIP-Seq_HL-1_Mouse0.97251686
80SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95986632
81FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95521555
82FOXA1_25329375_ChIP-Seq_VCAP_Human0.95521555
83TP63_19390658_ChIP-ChIP_HaCaT_Human0.93744856
84SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92824988
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91635816
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91635816
87CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91303962
88HOXB7_26014856_ChIP-Seq_BT474_Human0.91009754
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.89421504
90PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88913148
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.88323453
92IGF1R_20145208_ChIP-Seq_DFB_Human0.88233502
93P53_21459846_ChIP-Seq_SAOS-2_Human0.87494796
94FOXP1_21924763_ChIP-Seq_HESCs_Human0.87033151
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.86500983
96MYC_19829295_ChIP-Seq_ESCs_Human0.85461295
97SOX2_19829295_ChIP-Seq_ESCs_Human0.85395078
98NANOG_19829295_ChIP-Seq_ESCs_Human0.85395078
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.84529656
100XRN2_22483619_ChIP-Seq_HELA_Human0.84198351

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004858_abnormal_nervous_system5.39807407
2MP0009379_abnormal_foot_pigmentation4.00352178
3MP0004142_abnormal_muscle_tone3.98426850
4MP0006292_abnormal_olfactory_placode3.51575446
5MP0003122_maternal_imprinting3.46886511
6MP0001348_abnormal_lacrimal_gland2.63798166
7MP0000569_abnormal_digit_pigmentation2.48633669
8MP0008877_abnormal_DNA_methylation2.33223586
9MP0002653_abnormal_ependyma_morphology2.33049676
10MP0008789_abnormal_olfactory_epithelium2.27977342
11MP0006276_abnormal_autonomic_nervous2.23673587
12MP0003787_abnormal_imprinting2.12296943
13MP0003121_genomic_imprinting1.97609666
14MP0005499_abnormal_olfactory_system1.85451303
15MP0005394_taste/olfaction_phenotype1.85451303
16MP0004885_abnormal_endolymph1.84551093
17MP0002138_abnormal_hepatobiliary_system1.82718959
18MP0003880_abnormal_central_pattern1.82337888
19MP0002163_abnormal_gland_morphology1.77992546
20MP0004742_abnormal_vestibular_system1.72171189
21MP0008875_abnormal_xenobiotic_pharmacok1.71815957
22MP0002277_abnormal_respiratory_mucosa1.71621947
23MP0003646_muscle_fatigue1.70687876
24MP0005423_abnormal_somatic_nervous1.69024333
25MP0001984_abnormal_olfaction1.66090416
26MP0001873_stomach_inflammation1.61159845
27MP0005387_immune_system_phenotype1.60273254
28MP0001790_abnormal_immune_system1.60273254
29MP0002102_abnormal_ear_morphology1.58416702
30MP0005551_abnormal_eye_electrophysiolog1.58124534
31MP0002272_abnormal_nervous_system1.53781827
32MP0008872_abnormal_physiological_respon1.50856704
33MP0000372_irregular_coat_pigmentation1.50680453
34MP0002184_abnormal_innervation1.49209863
35MP0005645_abnormal_hypothalamus_physiol1.48141767
36MP0002876_abnormal_thyroid_physiology1.45136572
37MP0005671_abnormal_response_to1.44595168
38MP0001835_abnormal_antigen_presentation1.44303170
39MP0001188_hyperpigmentation1.43681294
40MP0001986_abnormal_taste_sensitivity1.40890931
41MP0000778_abnormal_nervous_system1.38900281
42MP0002095_abnormal_skin_pigmentation1.38010740
43MP0004147_increased_porphyrin_level1.36228957
44MP0001529_abnormal_vocalization1.33013422
45MP0006072_abnormal_retinal_apoptosis1.26596209
46MP0009046_muscle_twitch1.25236378
47MP0005075_abnormal_melanosome_morpholog1.24475590
48MP0004145_abnormal_muscle_electrophysio1.22290952
49MP0002063_abnormal_learning/memory/cond1.22177625
50MP0001440_abnormal_grooming_behavior1.19057899
51MP0002572_abnormal_emotion/affect_behav1.15835247
52MP0001485_abnormal_pinna_reflex1.14159341
53MP0000685_abnormal_immune_system1.13862955
54MP0001905_abnormal_dopamine_level1.13440053
55MP0002160_abnormal_reproductive_system1.13427981
56MP0009745_abnormal_behavioral_response1.11413948
57MP0003011_delayed_dark_adaptation1.10389137
58MP0002557_abnormal_social/conspecific_i1.09260252
59MP0005174_abnormal_tail_pigmentation1.08129929
60MP0005389_reproductive_system_phenotype1.06741966
61MP0003879_abnormal_hair_cell1.06056835
62MP0003123_paternal_imprinting1.04960569
63MP0000049_abnormal_middle_ear1.04619031
64MP0001968_abnormal_touch/_nociception1.03970403
65MP0001502_abnormal_circadian_rhythm1.02673942
66MP0000015_abnormal_ear_pigmentation1.02608276
67MP0001970_abnormal_pain_threshold1.00795061
68MP0000604_amyloidosis1.00144004
69MP0002938_white_spotting0.98690076
70MP0002733_abnormal_thermal_nociception0.95269046
71MP0001919_abnormal_reproductive_system0.94294323
72MP0003878_abnormal_ear_physiology0.93938085
73MP0005377_hearing/vestibular/ear_phenot0.93938085
74MP0005084_abnormal_gallbladder_morpholo0.93732005
75MP0001853_heart_inflammation0.93460035
76MP0005408_hypopigmentation0.93130447
77MP0001800_abnormal_humoral_immune0.93126178
78MP0002752_abnormal_somatic_nervous0.92122544
79MP0000026_abnormal_inner_ear0.88789311
80MP0001293_anophthalmia0.87161297
81MP0000955_abnormal_spinal_cord0.86231600
82MP0002234_abnormal_pharynx_morphology0.84944940
83MP0003890_abnormal_embryonic-extraembry0.83867997
84MP0002882_abnormal_neuron_morphology0.83318515
85MP0003635_abnormal_synaptic_transmissio0.82212953
86MP0002736_abnormal_nociception_after0.81615745
87MP0002928_abnormal_bile_duct0.79526553
88MP0004133_heterotaxia0.78650856
89MP0000631_abnormal_neuroendocrine_gland0.75205732
90MP0005310_abnormal_salivary_gland0.73576931
91MP0005195_abnormal_posterior_eye0.73302268
92MP0003329_amyloid_beta_deposits0.71847910
93MP0002734_abnormal_mechanical_nocicepti0.71361736
94MP0003136_yellow_coat_color0.70070187
95MP0001963_abnormal_hearing_physiology0.69626221
96MP0000427_abnormal_hair_cycle0.68765127
97MP0005379_endocrine/exocrine_gland_phen0.67135355
98MP0001501_abnormal_sleep_pattern0.66922032
99MP0002229_neurodegeneration0.66044372
100MP0003567_abnormal_fetal_cardiomyocyte0.65485558

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.22926400
2Molar tooth sign on MRI (HP:0002419)5.08190588
3Abnormality of midbrain morphology (HP:0002418)5.08190588
4Pancreatic fibrosis (HP:0100732)4.20881380
5Pancreatic cysts (HP:0001737)4.16995250
6Failure to thrive in infancy (HP:0001531)3.99874567
7Medial flaring of the eyebrow (HP:0010747)3.97537181
8Acute necrotizing encephalopathy (HP:0006965)3.92993632
9Gait imbalance (HP:0002141)3.87776505
10Congenital primary aphakia (HP:0007707)3.62633786
11Stomatitis (HP:0010280)3.61215176
12Abnormal hair whorl (HP:0010721)3.50675106
13Abnormality of the labia minora (HP:0012880)3.45189136
14Nephronophthisis (HP:0000090)3.35928378
15Abnormal mitochondria in muscle tissue (HP:0008316)3.32411843
16Acute encephalopathy (HP:0006846)3.28742671
17True hermaphroditism (HP:0010459)3.28740876
18Abnormality of cells of the erythroid lineage (HP:0012130)3.27274620
19Nephrogenic diabetes insipidus (HP:0009806)3.20010335
20Cystic liver disease (HP:0006706)3.19055739
21Polyphagia (HP:0002591)3.06428222
22Progressive macrocephaly (HP:0004481)3.06019125
23Absent rod-and cone-mediated responses on ERG (HP:0007688)3.05257903
24Mitochondrial inheritance (HP:0001427)2.94614877
25Pendular nystagmus (HP:0012043)2.91621254
26Congenital stationary night blindness (HP:0007642)2.90423725
27Poor coordination (HP:0002370)2.86859583
28Increased CSF lactate (HP:0002490)2.85402441
29Poor suck (HP:0002033)2.82628698
30Oligomenorrhea (HP:0000876)2.78061230
31Increased hepatocellular lipid droplets (HP:0006565)2.73643577
32Abnormal rod and cone electroretinograms (HP:0008323)2.72760399
33Abnormality of the renal cortex (HP:0011035)2.68826263
34Polydipsia (HP:0001959)2.67278956
35Abnormal drinking behavior (HP:0030082)2.67278956
36Abnormality of the renal medulla (HP:0100957)2.64502795
37Absent thumb (HP:0009777)2.58006330
38Vaginal atresia (HP:0000148)2.55484379
39Tubular atrophy (HP:0000092)2.54170457
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.52102393
41Absent/shortened dynein arms (HP:0200106)2.52102393
42Lipid accumulation in hepatocytes (HP:0006561)2.49357243
43Macrocytic anemia (HP:0001972)2.47185092
44Sclerocornea (HP:0000647)2.44860088
45IgG deficiency (HP:0004315)2.43959730
46Optic disc pallor (HP:0000543)2.41036550
47Cerebral edema (HP:0002181)2.39536273
48Genital tract atresia (HP:0001827)2.39214028
49Increased IgM level (HP:0003496)2.38628676
50Renal cortical cysts (HP:0000803)2.35032589
51Hip dysplasia (HP:0001385)2.34397356
52Postaxial foot polydactyly (HP:0001830)2.32734738
53Abnormal number of erythroid precursors (HP:0012131)2.30068746
54Specific learning disability (HP:0001328)2.29114526
55Type II lissencephaly (HP:0007260)2.27597460
56Aplasia/Hypoplasia of the spleen (HP:0010451)2.22693810
57Pallor (HP:0000980)2.19344005
58Anencephaly (HP:0002323)2.19245996
59Abnormal respiratory epithelium morphology (HP:0012253)2.19168605
60Abnormal respiratory motile cilium morphology (HP:0005938)2.19168605
61Narrow forehead (HP:0000341)2.18110108
62Elevated erythrocyte sedimentation rate (HP:0003565)2.09359264
63Asplenia (HP:0001746)2.08431330
64Aplasia/Hypoplasia of the tongue (HP:0010295)2.08300160
65Supernumerary spleens (HP:0009799)2.07974985
66Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07226227
67Polyuria (HP:0000103)2.06166070
68Abnormality of the nasal septum (HP:0000419)2.04979892
69Congenital hepatic fibrosis (HP:0002612)2.01062980
70Hypoplasia of the radius (HP:0002984)1.96910253
71Aganglionic megacolon (HP:0002251)1.95787569
72Abnormal eating behavior (HP:0100738)1.93013614
73Bile duct proliferation (HP:0001408)1.87496556
74Abnormal biliary tract physiology (HP:0012439)1.87496556
75Growth hormone deficiency (HP:0000824)1.86729318
76Status epilepticus (HP:0002133)1.86661568
77Hypoplasia of the ulna (HP:0003022)1.86573503
78Abnormal ciliary motility (HP:0012262)1.86002427
79Sleep apnea (HP:0010535)1.85392475
80Postaxial hand polydactyly (HP:0001162)1.85216657
81Abnormality of DNA repair (HP:0003254)1.83681357
82Forearm undergrowth (HP:0009821)1.83141388
83Median cleft lip (HP:0000161)1.82001821
84Renal Fanconi syndrome (HP:0001994)1.81499746
85Horseshoe kidney (HP:0000085)1.80329543
86Febrile seizures (HP:0002373)1.79331293
87Progressive microcephaly (HP:0000253)1.79330633
88Preaxial hand polydactyly (HP:0001177)1.77259166
89Abnormality of renal resorption (HP:0011038)1.74328681
90Hypogonadotrophic hypogonadism (HP:0000044)1.74164713
91Increased serum lactate (HP:0002151)1.73872145
92Chorioretinal atrophy (HP:0000533)1.73187787
93Aplasia/Hypoplasia of the lens (HP:0008063)1.73062338
94Male pseudohermaphroditism (HP:0000037)1.72433314
95Astigmatism (HP:0000483)1.71801077
96Agitation (HP:0000713)1.71230093
97Depressed nasal ridge (HP:0000457)1.71190631
98Leukodystrophy (HP:0002415)1.67998711
99Chronic hepatic failure (HP:0100626)1.67449593
100Aplasia/Hypoplasia of the ulna (HP:0006495)1.65012922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK43.69261531
2PINK13.58057238
3TXK3.56465844
4BMPR1B2.33565797
5STK392.33024718
6ADRBK22.13608771
7DYRK22.11836345
8MAPK132.02770454
9CASK1.98984206
10CAMK11.97044708
11TLK11.92200339
12EPHB21.91532792
13MAPKAPK31.88736365
14LRRK21.87676761
15ZAK1.74278636
16BCKDK1.69559757
17GRK11.68396527
18PIK3CA1.66553081
19OXSR11.58834407
20MAP2K61.57307768
21NUAK11.52497707
22CDK191.50075951
23PRKCH1.46487088
24MAP3K111.42500897
25NME11.36569202
26MAP3K91.36320221
27PHKG21.32357524
28PHKG11.32357524
29PRKCG1.30942058
30TIE11.23958569
31MAP4K11.20343532
32PAK31.17845250
33PRKCQ1.15199848
34TYRO31.15006204
35TEC1.13164408
36FRK1.12618173
37EIF2AK11.09087102
38ITK1.07261413
39CAMK1D0.98103427
40MUSK0.96604316
41RPS6KA60.91120110
42CAMKK20.90644818
43PRKD30.89172091
44NME20.89147795
45TAOK30.85952589
46RPS6KA20.85798268
47MARK10.85208130
48SRPK10.85074034
49BRAF0.82127246
50MAP4K20.81075303
51CAMK1G0.80951062
52WNK30.77899996
53KSR10.77744149
54DMPK0.77726818
55RPS6KC10.77218031
56RPS6KL10.77218031
57STK110.74474213
58TNIK0.72840834
59IKBKB0.70725152
60FES0.70610400
61PRKCZ0.70218196
62EIF2AK30.69909218
63STK160.68501463
64AKT30.65443122
65SGK4940.62398794
66SGK2230.62398794
67RPS6KA40.62136999
68PRKCI0.61667815
69NTRK20.60617326
70TSSK60.60242858
71PRKACA0.59428167
72BTK0.59208796
73SGK30.58531882
74IRAK10.57810822
75MKNK20.56632838
76ARAF0.56572582
77PRKCD0.54600537
78PASK0.54434720
79RPS6KA10.54374735
80PRKAA10.54320610
81INSRR0.53806457
82ADRBK10.53586890
83MAP3K120.53171701
84CSNK2A20.50396717
85MINK10.49813449
86PRKACG0.44390172
87MAP3K40.44339208
88CAMKK10.44319782
89WNK10.43580081
90LCK0.43546828
91DYRK30.42152198
92PNCK0.40828484
93CSNK1E0.40190932
94PRKCA0.38267629
95SGK10.38065441
96CAMK2A0.37914885
97EPHA30.37594816
98CSNK1A10.35439706
99CAMK40.34444653
100CSNK2A10.33497042

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.85751457
2Oxidative phosphorylation_Homo sapiens_hsa001903.47568896
3Sulfur relay system_Homo sapiens_hsa041223.22248145
4Parkinsons disease_Homo sapiens_hsa050122.94745690
5Protein export_Homo sapiens_hsa030602.58104235
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.53510487
7Asthma_Homo sapiens_hsa053102.41776197
8RNA polymerase_Homo sapiens_hsa030202.34974431
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.28322530
10Proteasome_Homo sapiens_hsa030502.14882589
11Cardiac muscle contraction_Homo sapiens_hsa042602.14403519
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.03819134
13Autoimmune thyroid disease_Homo sapiens_hsa053202.03635360
14Huntingtons disease_Homo sapiens_hsa050162.02288141
15Allograft rejection_Homo sapiens_hsa053302.00999750
16Primary immunodeficiency_Homo sapiens_hsa053401.97134905
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90657167
18Alzheimers disease_Homo sapiens_hsa050101.88507732
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.83628380
20Basal transcription factors_Homo sapiens_hsa030221.75842618
21Linoleic acid metabolism_Homo sapiens_hsa005911.70289707
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.64302369
23Homologous recombination_Homo sapiens_hsa034401.60576500
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.51345999
25Caffeine metabolism_Homo sapiens_hsa002321.49014363
26Pyrimidine metabolism_Homo sapiens_hsa002401.43923480
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.41595838
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41486369
29Dorso-ventral axis formation_Homo sapiens_hsa043201.40152537
30Nicotine addiction_Homo sapiens_hsa050331.38084870
31RNA degradation_Homo sapiens_hsa030181.36563838
32Phototransduction_Homo sapiens_hsa047441.27525788
33Steroid biosynthesis_Homo sapiens_hsa001001.25083044
34Fanconi anemia pathway_Homo sapiens_hsa034601.23765762
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22127357
36Butanoate metabolism_Homo sapiens_hsa006501.22056650
37Vitamin B6 metabolism_Homo sapiens_hsa007501.12974291
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11092746
39Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11023743
40One carbon pool by folate_Homo sapiens_hsa006701.09296431
41Nitrogen metabolism_Homo sapiens_hsa009101.09285789
42Nucleotide excision repair_Homo sapiens_hsa034201.04896818
43T cell receptor signaling pathway_Homo sapiens_hsa046601.04870434
44DNA replication_Homo sapiens_hsa030301.02351108
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97000933
46Cyanoamino acid metabolism_Homo sapiens_hsa004600.96816155
47Morphine addiction_Homo sapiens_hsa050320.93210411
48Fatty acid biosynthesis_Homo sapiens_hsa000610.92565072
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91028794
50Propanoate metabolism_Homo sapiens_hsa006400.82274023
51Hematopoietic cell lineage_Homo sapiens_hsa046400.81970230
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81501128
53Peroxisome_Homo sapiens_hsa041460.81015754
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.78628534
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77608430
56Sulfur metabolism_Homo sapiens_hsa009200.76438041
57Ether lipid metabolism_Homo sapiens_hsa005650.75464524
58Tryptophan metabolism_Homo sapiens_hsa003800.73180306
59Jak-STAT signaling pathway_Homo sapiens_hsa046300.72862673
60Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71061063
61GABAergic synapse_Homo sapiens_hsa047270.69190973
62Purine metabolism_Homo sapiens_hsa002300.67835899
63Fat digestion and absorption_Homo sapiens_hsa049750.61804351
64Metabolic pathways_Homo sapiens_hsa011000.57787994
65Insulin secretion_Homo sapiens_hsa049110.57380231
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56721561
67Arachidonic acid metabolism_Homo sapiens_hsa005900.54071459
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.53898861
69Type I diabetes mellitus_Homo sapiens_hsa049400.53708881
70Mismatch repair_Homo sapiens_hsa034300.51403867
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51006646
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.50041214
73RNA transport_Homo sapiens_hsa030130.50014443
74Graft-versus-host disease_Homo sapiens_hsa053320.46872168
75Mineral absorption_Homo sapiens_hsa049780.44316776
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.43555724
77Regulation of autophagy_Homo sapiens_hsa041400.42125359
78Retinol metabolism_Homo sapiens_hsa008300.39497177
79Axon guidance_Homo sapiens_hsa043600.39457958
80Rheumatoid arthritis_Homo sapiens_hsa053230.38344451
81Spliceosome_Homo sapiens_hsa030400.38041421
82Chemical carcinogenesis_Homo sapiens_hsa052040.36992109
83Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.36080703
84Synaptic vesicle cycle_Homo sapiens_hsa047210.35574511
85Arginine and proline metabolism_Homo sapiens_hsa003300.34897716
86Collecting duct acid secretion_Homo sapiens_hsa049660.34755807
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.33506608
88Fatty acid metabolism_Homo sapiens_hsa012120.31820739
89Serotonergic synapse_Homo sapiens_hsa047260.30238388
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29656493
91Glutamatergic synapse_Homo sapiens_hsa047240.26478417
92Olfactory transduction_Homo sapiens_hsa047400.24979913
93Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23186815
94Glycerolipid metabolism_Homo sapiens_hsa005610.21848634
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.19821258
96Measles_Homo sapiens_hsa051620.19799024
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19609158
98Basal cell carcinoma_Homo sapiens_hsa052170.17719921
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.16740473
100Ovarian steroidogenesis_Homo sapiens_hsa049130.16500197

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