ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein neddylation (GO:0045116)	6.65565630
2	DNA deamination (GO:0045006)	5.69443609
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.95260743
4	pyrimidine nucleobase catabolic process (GO:0006208)	4.84982469
5	behavioral response to nicotine (GO:0035095)	4.64152894
6	chaperone-mediated protein transport (GO:0072321)	4.47739534
7	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.45702059
8	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.42558565
9	nonmotile primary cilium assembly (GO:0035058)	4.37614475
10	cytidine deamination (GO:0009972)	4.13469461
11	cytidine metabolic process (GO:0046087)	4.13469461
12	cytidine catabolic process (GO:0006216)	4.13469461
13	nucleobase catabolic process (GO:0046113)	3.99576113
14	regulation of respiratory system process (GO:0044065)	3.78669845
15	replication fork processing (GO:0031297)	3.77757436
16	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	3.70858712
17	response to redox state (GO:0051775)	3.68497538
18	retinal ganglion cell axon guidance (GO:0031290)	3.68495160
19	sequestering of actin monomers (GO:0042989)	3.63311042
20	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.61646356
21	regulation of mitotic spindle checkpoint (GO:1903504)	3.58588300
22	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.58588300
23	protein complex biogenesis (GO:0070271)	3.49612115
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.49052189
25	NADH dehydrogenase complex assembly (GO:0010257)	3.49052189
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.49052189
27	negative regulation of response to food (GO:0032096)	3.45716332
28	negative regulation of appetite (GO:0032099)	3.45716332
29	regulation of cilium movement (GO:0003352)	3.42912195
30	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.39464608
31	signal peptide processing (GO:0006465)	3.38585538
32	olfactory bulb development (GO:0021772)	3.36105565
33	postsynaptic membrane organization (GO:0001941)	3.30348951
34	neuronal action potential propagation (GO:0019227)	3.20580098
35	dendritic spine morphogenesis (GO:0060997)	3.14904074
36	negative regulation of DNA recombination (GO:0045910)	3.14408732
37	axoneme assembly (GO:0035082)	3.12564607
38	negative regulation by host of viral transcription (GO:0043922)	3.09280053
39	DNA double-strand break processing (GO:0000729)	3.02129634
40	inner mitochondrial membrane organization (GO:0007007)	3.01917060
41	protein polyglutamylation (GO:0018095)	3.00753782
42	mitochondrial respiratory chain complex assembly (GO:0033108)	3.00707145
43	axonal fasciculation (GO:0007413)	3.00137165
44	spinal cord association neuron differentiation (GO:0021527)	3.00111431
45	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.93832477
46	regulation of respiratory gaseous exchange (GO:0043576)	2.93590295
47	negative regulation of telomere maintenance (GO:0032205)	2.86268765
48	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.86137706
49	ATP synthesis coupled proton transport (GO:0015986)	2.86137706
50	cytochrome complex assembly (GO:0017004)	2.86132800
51	respiratory chain complex IV assembly (GO:0008535)	2.85028546
52	DNA demethylation (GO:0080111)	2.82841497
53	response to pheromone (GO:0019236)	2.77994997
54	negative regulation of axon extension involved in axon guidance (GO:0048843)	2.76380973
55	ovulation cycle (GO:0042698)	2.75647948
56	cellular ketone body metabolic process (GO:0046950)	2.72369742
57	regulation of collateral sprouting (GO:0048670)	2.71157567
58	regulation of action potential (GO:0098900)	2.70674023
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.69231570
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.69231570
61	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.69091242
62	nucleotide transmembrane transport (GO:1901679)	2.69021346
63	isoprenoid biosynthetic process (GO:0008299)	2.68917725
64	hydrogen ion transmembrane transport (GO:1902600)	2.68841557
65	DNA strand renaturation (GO:0000733)	2.68424390
66	electron transport chain (GO:0022900)	2.66568997
67	respiratory electron transport chain (GO:0022904)	2.66530668
68	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.66374230
69	photoreceptor cell maintenance (GO:0045494)	2.64652541
70	response to misfolded protein (GO:0051788)	2.64578609
71	piRNA metabolic process (GO:0034587)	2.63934733
72	proton transport (GO:0015992)	2.63594318
73	male meiosis (GO:0007140)	2.62640416
74	arginine catabolic process (GO:0006527)	2.62384524
75	microtubule bundle formation (GO:0001578)	2.61729649
76	ncRNA 3-end processing (GO:0043628)	2.60641158
77	intracellular protein transmembrane import (GO:0044743)	2.59282962
78	attachment of spindle microtubules to kinetochore (GO:0008608)	2.58248802
79	hydrogen transport (GO:0006818)	2.58104301
80	spinal cord development (GO:0021510)	2.57866638
81	proteasome assembly (GO:0043248)	2.57665527
82	cellular biogenic amine catabolic process (GO:0042402)	2.57078931
83	amine catabolic process (GO:0009310)	2.57078931
84	DNA damage response, detection of DNA damage (GO:0042769)	2.54929955
85	negative regulation of axon guidance (GO:1902668)	2.54623163
86	epithelial cilium movement (GO:0003351)	2.53980659
87	establishment of mitochondrion localization (GO:0051654)	2.53774866
88	neuron recognition (GO:0008038)	2.53659129
89	protein-cofactor linkage (GO:0018065)	2.52380804
90	melanosome localization (GO:0032400)	2.50403987
91	synaptic transmission, cholinergic (GO:0007271)	2.50257732
92	adaptation of signaling pathway (GO:0023058)	2.50177163
93	presynaptic membrane organization (GO:0097090)	2.49339503
94	presynaptic membrane assembly (GO:0097105)	2.48684149
95	neural tube formation (GO:0001841)	2.46917468
96	cilium morphogenesis (GO:0060271)	2.46809018
97	intraciliary transport (GO:0042073)	2.46589228
98	cell proliferation in forebrain (GO:0021846)	2.45764302
99	regulation of microtubule-based movement (GO:0060632)	2.44685213
100	membrane hyperpolarization (GO:0060081)	2.44479156

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.82676837
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.43126815
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.25521531
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.03874040
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.85911943
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.72185028
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.71843368
8	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.69169018
9	VDR_22108803_ChIP-Seq_LS180_Human	2.44710049
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.38456823
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.34722521
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.34206635
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.25524863
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.07623314
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.04409252
16	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.02277102
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.95613179
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.91867896
19	IGF1R_20145208_ChIP-Seq_DFB_Human	1.87164680
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.80909043
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80596543
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.79729899
23	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.79113900
24	EWS_26573619_Chip-Seq_HEK293_Human	1.78160554
25	P300_19829295_ChIP-Seq_ESCs_Human	1.74308719
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.72698927
27	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.70797478
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.68573496
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.59479140
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.57261987
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.55319225
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.53293545
33	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.50171445
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.48295516
35	FUS_26573619_Chip-Seq_HEK293_Human	1.43509606
36	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40651002
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.37797671
38	SMAD4_21799915_ChIP-Seq_A2780_Human	1.33653588
39	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.30794369
40	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.30480663
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.29926513
42	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.29373656
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.28397978
44	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.27900400
45	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26788195
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.26725440
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.26725440
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.26200590
49	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26199930
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.26199930
51	VDR_23849224_ChIP-Seq_CD4+_Human	1.25746875
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22233666
53	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.21974580
54	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.18948228
55	BCAT_22108803_ChIP-Seq_LS180_Human	1.17978527
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17449269
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17382511
58	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.17127358
59	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16582097
60	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15174517
61	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.13650841
62	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.12839633
63	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.11502453
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10389765
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10028596
66	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09896051
67	AR_25329375_ChIP-Seq_VCAP_Human	1.09507689
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09467046
69	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.09457830
70	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.09410964
71	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.08737364
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08085463
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.07518130
74	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.07446171
75	P53_22387025_ChIP-Seq_ESCs_Mouse	1.07354556
76	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.06632432
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.05708744
78	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05214040
79	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.04026806
80	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.03779279
81	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.02608002
82	FOXP3_21729870_ChIP-Seq_TREG_Human	1.02549897
83	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.02277886
84	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.02253846
85	TCF4_23295773_ChIP-Seq_U87_Human	1.01924790
86	STAT3_23295773_ChIP-Seq_U87_Human	1.01339262
87	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00420155
88	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.00298382
89	MYC_18940864_ChIP-ChIP_HL60_Human	0.99429426
90	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.99375344
91	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98979376
92	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.98636969
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.98378864
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.98147030
95	SOX2_19829295_ChIP-Seq_ESCs_Human	0.97099187
96	NANOG_19829295_ChIP-Seq_ESCs_Human	0.97099187
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96738987
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.95394832
99	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95281905
100	P300_18555785_Chip-Seq_ESCs_Mouse	0.94868581

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005423_abnormal_somatic_nervous	3.80392596
2	MP0008877_abnormal_DNA_methylation	3.35322379
3	MP0001984_abnormal_olfaction	3.21838579
4	MP0003122_maternal_imprinting	2.66082230
5	MP0008789_abnormal_olfactory_epithelium	2.62972934
6	MP0003787_abnormal_imprinting	2.53236243
7	MP0000569_abnormal_digit_pigmentation	2.47469969
8	MP0001968_abnormal_touch/_nociception	2.28461960
9	MP0005551_abnormal_eye_electrophysiolog	2.23322058
10	MP0005394_taste/olfaction_phenotype	2.12184567
11	MP0005499_abnormal_olfactory_system	2.12184567
12	MP0003121_genomic_imprinting	2.10401690
13	MP0005645_abnormal_hypothalamus_physiol	2.10099584
14	MP0003880_abnormal_central_pattern	2.09721156
15	MP0002736_abnormal_nociception_after	2.07471220
16	MP0004142_abnormal_muscle_tone	2.07125175
17	MP0006276_abnormal_autonomic_nervous	1.96386242
18	MP0004147_increased_porphyrin_level	1.92568644
19	MP0000778_abnormal_nervous_system	1.84990748
20	MP0003011_delayed_dark_adaptation	1.82342494
21	MP0002653_abnormal_ependyma_morphology	1.81586203
22	MP0008995_early_reproductive_senescence	1.75574679
23	MP0002272_abnormal_nervous_system	1.71070345
24	MP0003786_premature_aging	1.68452267
25	MP0002928_abnormal_bile_duct	1.64892169
26	MP0009046_muscle_twitch	1.63143025
27	MP0005253_abnormal_eye_physiology	1.62550408
28	MP0004145_abnormal_muscle_electrophysio	1.62284987
29	MP0009745_abnormal_behavioral_response	1.60308372
30	MP0000427_abnormal_hair_cycle	1.59604695
31	MP0006292_abnormal_olfactory_placode	1.56889560
32	MP0001529_abnormal_vocalization	1.55761660
33	MP0002735_abnormal_chemical_nociception	1.54185065
34	MP0001188_hyperpigmentation	1.54039050
35	MP0001485_abnormal_pinna_reflex	1.52475463
36	MP0001293_anophthalmia	1.49827185
37	MP0004742_abnormal_vestibular_system	1.46772617
38	MP0003646_muscle_fatigue	1.43307765
39	MP0004885_abnormal_endolymph	1.41457589
40	MP0002063_abnormal_learning/memory/cond	1.38192097
41	MP0002557_abnormal_social/conspecific_i	1.37980040
42	MP0002572_abnormal_emotion/affect_behav	1.37226695
43	MP0001970_abnormal_pain_threshold	1.37068716
44	MP0003635_abnormal_synaptic_transmissio	1.37003053
45	MP0002909_abnormal_adrenal_gland	1.36979638
46	MP0006072_abnormal_retinal_apoptosis	1.36364196
47	MP0001502_abnormal_circadian_rhythm	1.36026488
48	MP0004133_heterotaxia	1.33920727
49	MP0002938_white_spotting	1.32212121
50	MP0001486_abnormal_startle_reflex	1.30798335
51	MP0000631_abnormal_neuroendocrine_gland	1.28913738
52	MP0002163_abnormal_gland_morphology	1.27875453
53	MP0001905_abnormal_dopamine_level	1.26216835
54	MP0002837_dystrophic_cardiac_calcinosis	1.22494127
55	MP0002234_abnormal_pharynx_morphology	1.22437045
56	MP0003186_abnormal_redox_activity	1.21001533
57	MP0002734_abnormal_mechanical_nocicepti	1.20929288
58	MP0002067_abnormal_sensory_capabilities	1.20115733
59	MP0002160_abnormal_reproductive_system	1.18735327
60	MP0002064_seizures	1.17724612
61	MP0005391_vision/eye_phenotype	1.16088902
62	MP0000955_abnormal_spinal_cord	1.15791820
63	MP0001440_abnormal_grooming_behavior	1.15733609
64	MP0008872_abnormal_physiological_respon	1.14687903
65	MP0002733_abnormal_thermal_nociception	1.12562988
66	MP0005084_abnormal_gallbladder_morpholo	1.10964243
67	MP0002184_abnormal_innervation	1.09283649
68	MP0005389_reproductive_system_phenotype	1.08573109
69	MP0002638_abnormal_pupillary_reflex	1.06741560
70	MP0002752_abnormal_somatic_nervous	1.06740276
71	MP0002102_abnormal_ear_morphology	1.05042080
72	MP0000647_abnormal_sebaceous_gland	1.04957728
73	MP0004043_abnormal_pH_regulation	1.04558686
74	MP0002751_abnormal_autonomic_nervous	1.04084614
75	MP0003195_calcinosis	1.01455934
76	MP0002882_abnormal_neuron_morphology	1.01090627
77	MP0002095_abnormal_skin_pigmentation	0.99568940
78	MP0005195_abnormal_posterior_eye	0.97127813
79	MP0001986_abnormal_taste_sensitivity	0.94506842
80	MP0000049_abnormal_middle_ear	0.94415732
81	MP0004924_abnormal_behavior	0.90170587
82	MP0005386_behavior/neurological_phenoty	0.90170587
83	MP0002233_abnormal_nose_morphology	0.89364507
84	MP0001348_abnormal_lacrimal_gland	0.89154773
85	MP0001919_abnormal_reproductive_system	0.88560888
86	MP0005367_renal/urinary_system_phenotyp	0.87366495
87	MP0000516_abnormal_urinary_system	0.87366495
88	MP0000230_abnormal_systemic_arterial	0.86540777
89	MP0002876_abnormal_thyroid_physiology	0.86414968
90	MP0002210_abnormal_sex_determination	0.84578755
91	MP0003119_abnormal_digestive_system	0.81557170
92	MP0003123_paternal_imprinting	0.79080426
93	MP0003698_abnormal_male_reproductive	0.77421590
94	MP0002090_abnormal_vision	0.77346921
95	MP0002152_abnormal_brain_morphology	0.75590914
96	MP0004215_abnormal_myocardial_fiber	0.73607415
97	MP0008007_abnormal_cellular_replicative	0.73098695
98	MP0008569_lethality_at_weaning	0.73094404
99	MP0004811_abnormal_neuron_physiology	0.72814408
100	MP0005174_abnormal_tail_pigmentation	0.72485523

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.98816866
2	Pancreatic fibrosis (HP:0100732)	3.95125393
3	Hepatocellular necrosis (HP:0001404)	3.62025875
4	Acute necrotizing encephalopathy (HP:0006965)	3.61188948
5	Abnormality of midbrain morphology (HP:0002418)	3.57314827
6	Molar tooth sign on MRI (HP:0002419)	3.57314827
7	Medial flaring of the eyebrow (HP:0010747)	3.57011085
8	True hermaphroditism (HP:0010459)	3.52108019
9	Acute encephalopathy (HP:0006846)	3.41696661
10	Mitochondrial inheritance (HP:0001427)	3.37058457
11	Gait imbalance (HP:0002141)	3.33988252
12	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.32003877
13	Nephronophthisis (HP:0000090)	3.27919525
14	Nephrogenic diabetes insipidus (HP:0009806)	3.11860162
15	Hepatic necrosis (HP:0002605)	3.06049228
16	Agitation (HP:0000713)	3.03830731
17	Abnormal mitochondria in muscle tissue (HP:0008316)	2.97970419
18	Progressive macrocephaly (HP:0004481)	2.97728592
19	Abnormal rod and cone electroretinograms (HP:0008323)	2.96818898
20	Congenital primary aphakia (HP:0007707)	2.94874894
21	Increased CSF lactate (HP:0002490)	2.88328982
22	Postaxial foot polydactyly (HP:0001830)	2.76000093
23	Abnormality of the renal medulla (HP:0100957)	2.69682176
24	Polyphagia (HP:0002591)	2.68665569
25	Focal seizures (HP:0007359)	2.68659162
26	Abnormality of the labia minora (HP:0012880)	2.64075897
27	Hypomagnesemia (HP:0002917)	2.63781165
28	Hyperventilation (HP:0002883)	2.60590495
29	Cystic liver disease (HP:0006706)	2.60316428
30	Sclerocornea (HP:0000647)	2.55622819
31	Broad-based gait (HP:0002136)	2.46599693
32	Optic disc pallor (HP:0000543)	2.45081594
33	Occipital encephalocele (HP:0002085)	2.44525732
34	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.43000684
35	Chronic hepatic failure (HP:0100626)	2.40281770
36	Vaginal atresia (HP:0000148)	2.36553560
37	Genital tract atresia (HP:0001827)	2.34511058
38	Lissencephaly (HP:0001339)	2.34126884
39	Abnormality of the renal cortex (HP:0011035)	2.33232203
40	Febrile seizures (HP:0002373)	2.30752745
41	Cerebral edema (HP:0002181)	2.28050064
42	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.27395258
43	Hyperglycinemia (HP:0002154)	2.26771062
44	Congenital stationary night blindness (HP:0007642)	2.24714515
45	Atonic seizures (HP:0010819)	2.21433173
46	Abnormality of magnesium homeostasis (HP:0004921)	2.20815998
47	Genetic anticipation (HP:0003743)	2.17198564
48	Constricted visual fields (HP:0001133)	2.16940249
49	Narrow forehead (HP:0000341)	2.13222654
50	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.12664198
51	Anencephaly (HP:0002323)	2.11590570
52	3-Methylglutaconic aciduria (HP:0003535)	2.08116142
53	Postaxial hand polydactyly (HP:0001162)	2.07703881
54	Male pseudohermaphroditism (HP:0000037)	2.07479983
55	Pachygyria (HP:0001302)	2.07215978
56	Myokymia (HP:0002411)	2.05066560
57	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.03787031
58	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.03787031
59	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.03015783
60	Hypothermia (HP:0002045)	2.02810117
61	Abnormality of the corticospinal tract (HP:0002492)	2.02151878
62	Poor coordination (HP:0002370)	2.02106034
63	Preaxial hand polydactyly (HP:0001177)	2.01699974
64	Methylmalonic aciduria (HP:0012120)	2.00015142
65	Amblyopia (HP:0000646)	1.99095456
66	Congenital hepatic fibrosis (HP:0002612)	1.95181167
67	Reticulocytopenia (HP:0001896)	1.94449406
68	Failure to thrive in infancy (HP:0001531)	1.93880233
69	Polyuria (HP:0000103)	1.93693753
70	Generalized tonic-clonic seizures (HP:0002069)	1.92555827
71	Abolished electroretinogram (ERG) (HP:0000550)	1.92449151
72	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.91990396
73	Optic nerve hypoplasia (HP:0000609)	1.91709753
74	Type 2 muscle fiber atrophy (HP:0003554)	1.91602061
75	Abnormality of alanine metabolism (HP:0010916)	1.87930099
76	Hyperalaninemia (HP:0003348)	1.87930099
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87930099
78	Septo-optic dysplasia (HP:0100842)	1.86957020
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.86518752
80	Limb dystonia (HP:0002451)	1.86155527
81	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.85851984
82	Hypoplasia of the brainstem (HP:0002365)	1.85851984
83	Tubular atrophy (HP:0000092)	1.84973406
84	Respiratory failure (HP:0002878)	1.84931022
85	Polydipsia (HP:0001959)	1.84223407
86	Abnormal drinking behavior (HP:0030082)	1.84223407
87	Highly arched eyebrow (HP:0002553)	1.84007904
88	Hip dysplasia (HP:0001385)	1.82994906
89	Small hand (HP:0200055)	1.81894981
90	Facial cleft (HP:0002006)	1.80971678
91	Adrenal hypoplasia (HP:0000835)	1.80003392
92	Lactic acidosis (HP:0003128)	1.79783092
93	Bile duct proliferation (HP:0001408)	1.78560579
94	Abnormal biliary tract physiology (HP:0012439)	1.78560579
95	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77383486
96	Tubulointerstitial nephritis (HP:0001970)	1.76792614
97	Renal cortical cysts (HP:0000803)	1.76681323
98	Amyotrophic lateral sclerosis (HP:0007354)	1.75953973
99	Chorioretinal atrophy (HP:0000533)	1.75499257
100	Methylmalonic acidemia (HP:0002912)	1.75488633

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CASK	4.30801168
2	MARK1	3.59482162
3	WNK3	3.32194168
4	TXK	2.89516740
5	WNK4	2.50250084
6	FRK	2.47024627
7	TRIM28	2.46053585
8	MAP3K4	2.10443483
9	STK39	1.96110380
10	NUAK1	1.95497280
11	DYRK2	1.90889733
12	AKT3	1.90374065
13	PDK2	1.89978180
14	MKNK2	1.77927079
15	MAPK13	1.74698370
16	MAP4K2	1.70594817
17	BCR	1.67443619
18	BUB1	1.65541313
19	MAP2K7	1.51805842
20	EPHB2	1.47942401
21	BCKDK	1.45685909
22	PINK1	1.42735593
23	OXSR1	1.41605093
24	GRK1	1.39768676
25	ADRBK2	1.37486173
26	CAMK1D	1.36803897
27	LIMK1	1.35429798
28	SIK3	1.33407409
29	SRPK1	1.32940636
30	NTRK2	1.29529343
31	MINK1	1.28101522
32	STK16	1.26127742
33	CAMK1G	1.26058615
34	PIK3CA	1.23007099
35	ERBB3	1.22486088
36	DYRK3	1.22436782
37	PLK4	1.21785806
38	PAK3	1.18703284
39	BMPR1B	1.15594785
40	MST4	1.13463651
41	TNIK	1.06902739
42	ZAK	1.04158663
43	CDC7	0.98528828
44	CAMK1	0.92362953
45	CSNK1G2	0.85995373
46	EPHA4	0.85037724
47	PRKCG	0.84852109
48	PRKCQ	0.84318763
49	NME1	0.78255570
50	DYRK1A	0.73977187
51	MKNK1	0.73915682
52	PKN1	0.73767608
53	NEK1	0.73529397
54	FES	0.70897321
55	FER	0.70134294
56	PLK2	0.69349769
57	PNCK	0.68543124
58	INSRR	0.67418207
59	ITK	0.66961960
60	PRKCE	0.66926009
61	ROCK1	0.63811846
62	RPS6KA4	0.59960639
63	BRAF	0.56443710
64	PLK3	0.54593098
65	CAMK2A	0.53535804
66	ACVR1B	0.52896749
67	WEE1	0.51884403
68	VRK1	0.51134592
69	FGFR2	0.50818759
70	PLK1	0.50541017
71	WNK1	0.49690216
72	PRKACA	0.49286360
73	SGK223	0.49025414
74	SGK494	0.49025414
75	NTRK3	0.48530103
76	PRKCZ	0.47714708
77	CSNK1A1	0.46938599
78	CSNK1G1	0.43861703
79	TLK1	0.42623500
80	RPS6KA5	0.42208007
81	NEK2	0.39083716
82	CDK5	0.38156647
83	CSNK1D	0.36655262
84	PHKG2	0.36548853
85	PHKG1	0.36548853
86	KSR1	0.36227333
87	ADRBK1	0.35002865
88	CSNK2A1	0.34849520
89	ATM	0.34826831
90	CSNK1E	0.34766336
91	PRKCA	0.33836730
92	CAMKK2	0.33631955
93	CSNK1G3	0.33590924
94	CAMK2D	0.32269156
95	OBSCN	0.32113257
96	MAP2K4	0.32020394
97	DMPK	0.31290204
98	CDK19	0.31283099
99	CSNK2A2	0.31145376
100	BRSK2	0.30861897

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.85082167
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.56144935
3	Protein export_Homo sapiens_hsa03060	3.44873008
4	Parkinsons disease_Homo sapiens_hsa05012	3.04504585
5	Proteasome_Homo sapiens_hsa03050	2.99925335
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.61044655
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.59883106
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.52615347
9	Propanoate metabolism_Homo sapiens_hsa00640	2.32035605
10	Basal transcription factors_Homo sapiens_hsa03022	2.21963505
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.16099534
12	Steroid biosynthesis_Homo sapiens_hsa00100	2.16093273
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.14865956
14	Alzheimers disease_Homo sapiens_hsa05010	1.97144496
15	Butanoate metabolism_Homo sapiens_hsa00650	1.94772623
16	Homologous recombination_Homo sapiens_hsa03440	1.94052147
17	Huntingtons disease_Homo sapiens_hsa05016	1.90724041
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.73606109
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73087956
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69287680
21	Nicotine addiction_Homo sapiens_hsa05033	1.63786884
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57576845
23	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47768222
24	Phototransduction_Homo sapiens_hsa04744	1.47030294
25	Nucleotide excision repair_Homo sapiens_hsa03420	1.45864054
26	RNA polymerase_Homo sapiens_hsa03020	1.42610981
27	Peroxisome_Homo sapiens_hsa04146	1.42593689
28	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.39378402
29	RNA degradation_Homo sapiens_hsa03018	1.34012566
30	Caffeine metabolism_Homo sapiens_hsa00232	1.20475698
31	Mismatch repair_Homo sapiens_hsa03430	1.20227788
32	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.19355082
33	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.09852831
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.06798330
35	beta-Alanine metabolism_Homo sapiens_hsa00410	1.04738811
36	Fanconi anemia pathway_Homo sapiens_hsa03460	1.03700469
37	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.03565572
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.99825845
39	Primary immunodeficiency_Homo sapiens_hsa05340	0.99077424
40	Ether lipid metabolism_Homo sapiens_hsa00565	0.98239570
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.93762198
42	RNA transport_Homo sapiens_hsa03013	0.91803734
43	Fatty acid elongation_Homo sapiens_hsa00062	0.90356140
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.90149750
45	GABAergic synapse_Homo sapiens_hsa04727	0.83750110
46	Glutamatergic synapse_Homo sapiens_hsa04724	0.83251986
47	Insulin secretion_Homo sapiens_hsa04911	0.80916752
48	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.78456295
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.78141711
50	Fatty acid degradation_Homo sapiens_hsa00071	0.77770646
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.77267202
52	Dopaminergic synapse_Homo sapiens_hsa04728	0.76089615
53	Taste transduction_Homo sapiens_hsa04742	0.75433869
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73624699
55	Ribosome_Homo sapiens_hsa03010	0.72828184
56	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.70945836
57	Selenocompound metabolism_Homo sapiens_hsa00450	0.70915239
58	Morphine addiction_Homo sapiens_hsa05032	0.70112261
59	Retinol metabolism_Homo sapiens_hsa00830	0.64336965
60	Metabolic pathways_Homo sapiens_hsa01100	0.63814132
61	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.62190777
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61402573
63	Rheumatoid arthritis_Homo sapiens_hsa05323	0.60077333
64	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.59606949
65	Circadian entrainment_Homo sapiens_hsa04713	0.59080413
66	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.58786246
67	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57532623
68	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.56780681
69	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.54698253
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.54143785
71	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53574494
72	Vibrio cholerae infection_Homo sapiens_hsa05110	0.53132515
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.52721898
74	Serotonergic synapse_Homo sapiens_hsa04726	0.49371890
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.48431713
76	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47898852
77	Olfactory transduction_Homo sapiens_hsa04740	0.47441815
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44126104
79	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.43151526
80	Amphetamine addiction_Homo sapiens_hsa05031	0.42873338
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42537852
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.41626562
83	Oocyte meiosis_Homo sapiens_hsa04114	0.41322837
84	Axon guidance_Homo sapiens_hsa04360	0.40209461
85	Salivary secretion_Homo sapiens_hsa04970	0.39939993
86	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38160369
87	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37987211
88	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.36348939
89	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.35156830
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34491442
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.33629217
92	Cocaine addiction_Homo sapiens_hsa05030	0.33049657
93	Purine metabolism_Homo sapiens_hsa00230	0.31660804
94	Salmonella infection_Homo sapiens_hsa05132	0.31304003
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.28667574
96	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.28515540
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28392649
98	Non-homologous end-joining_Homo sapiens_hsa03450	0.27591014
99	Sulfur metabolism_Homo sapiens_hsa00920	0.27566264
100	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27460053

RPL36AP41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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