ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	translational termination (GO:0006415)	9.97872063
2	ribosomal small subunit assembly (GO:0000028)	8.86057111
3	translational elongation (GO:0006414)	8.33405185
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	8.27695488
5	cotranslational protein targeting to membrane (GO:0006613)	8.12794090
6	protein targeting to ER (GO:0045047)	8.10754761
7	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.79364993
8	cellular protein complex disassembly (GO:0043624)	7.61182798
9	protein localization to endoplasmic reticulum (GO:0070972)	7.61019355
10	viral life cycle (GO:0019058)	7.51840674
11	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	7.26691201
12	maturation of SSU-rRNA (GO:0030490)	7.00076871
13	chaperone-mediated protein transport (GO:0072321)	6.72761039
14	protein complex disassembly (GO:0043241)	6.44759882
15	translational initiation (GO:0006413)	6.23764677
16	macromolecular complex disassembly (GO:0032984)	6.00646168
17	ATP synthesis coupled proton transport (GO:0015986)	5.75546103
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.75546103
19	protein targeting to membrane (GO:0006612)	5.68836832
20	ribosomal large subunit biogenesis (GO:0042273)	5.33694254
21	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.97689315
22	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.94661787
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.84703133
24	translation (GO:0006412)	4.82086449
25	mRNA catabolic process (GO:0006402)	4.61966965
26	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.47315579
27	substrate-independent telencephalic tangential migration (GO:0021826)	4.47315579
28	ribonucleoprotein complex biogenesis (GO:0022613)	4.30831500
29	cellular component biogenesis (GO:0044085)	4.20088711
30	respiratory electron transport chain (GO:0022904)	4.13178908
31	behavioral response to nicotine (GO:0035095)	4.12969369
32	RNA catabolic process (GO:0006401)	4.12911724
33	electron transport chain (GO:0022900)	4.05592922
34	protein complex biogenesis (GO:0070271)	3.97752706
35	establishment of protein localization to membrane (GO:0090150)	3.93738796
36	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.91008649
37	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.91008649
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.87793223
39	NADH dehydrogenase complex assembly (GO:0010257)	3.87793223
40	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.87793223
41	cell proliferation in forebrain (GO:0021846)	3.85042059
42	protein targeting (GO:0006605)	3.61481610
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60843112
44	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.50896180
45	ATP biosynthetic process (GO:0006754)	3.48271992
46	protein neddylation (GO:0045116)	3.45362458
47	CTP metabolic process (GO:0046036)	3.41357367
48	CTP biosynthetic process (GO:0006241)	3.41357367
49	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.40925626
50	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.38719909
51	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.34421717
52	ncRNA 3-end processing (GO:0043628)	3.31735474
53	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.30263222
54	establishment of protein localization to organelle (GO:0072594)	3.26457454
55	GTP biosynthetic process (GO:0006183)	3.17662131
56	protein localization to membrane (GO:0072657)	3.14297442
57	DNA deamination (GO:0045006)	3.07787618
58	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.05182247
59	pattern specification involved in kidney development (GO:0061004)	3.05139906
60	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.03896906
61	pyrimidine nucleotide catabolic process (GO:0006244)	3.03695498
62	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.03484178
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.00808873
64	cardiovascular system development (GO:0072358)	2.99757888
65	activation of MAPKKK activity (GO:0000185)	2.99138171
66	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.95615235
67	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.92862969
68	forebrain morphogenesis (GO:0048853)	2.86783506
69	positive regulation of T cell apoptotic process (GO:0070234)	2.84929442
70	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.82353498
71	nucleoside triphosphate biosynthetic process (GO:0009142)	2.81330826
72	hydrogen ion transmembrane transport (GO:1902600)	2.78765063
73	regulation of cellular respiration (GO:0043457)	2.75563641
74	segment specification (GO:0007379)	2.74472811
75	neuron fate determination (GO:0048664)	2.71377485
76	positive regulation of respiratory burst (GO:0060267)	2.71233449
77	UTP biosynthetic process (GO:0006228)	2.69396214
78	spinal cord association neuron differentiation (GO:0021527)	2.68286293
79	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.65249927
80	intracellular protein transmembrane import (GO:0044743)	2.59010086
81	somite development (GO:0061053)	2.57565313
82	nonmotile primary cilium assembly (GO:0035058)	2.54897514
83	negative regulation of appetite (GO:0032099)	2.51734751
84	negative regulation of response to food (GO:0032096)	2.51734751
85	rRNA metabolic process (GO:0016072)	2.50378781
86	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.49153341
87	axon ensheathment in central nervous system (GO:0032291)	2.44657054
88	central nervous system myelination (GO:0022010)	2.44657054
89	hypothalamus development (GO:0021854)	2.44652375
90	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.44003265
91	proton transport (GO:0015992)	2.43990382
92	tongue development (GO:0043586)	2.43626004
93	protein polyglutamylation (GO:0018095)	2.41075783
94	UTP metabolic process (GO:0046051)	2.40970486
95	rRNA processing (GO:0006364)	2.40501744
96	nucleotide salvage (GO:0043173)	2.39612804
97	hydrogen transport (GO:0006818)	2.36839438
98	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.33783487
99	viral transcription (GO:0019083)	10.4664596
100	ribosomal small subunit biogenesis (GO:0042274)	10.4621870

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.45953331
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.74201903
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.41679481
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.79356401
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.46015909
6	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.36104893
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.29849930
8	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.22600288
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.15451914
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.14789328
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.12890282
12	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.06442915
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.04561248
14	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.04127951
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.03332814
16	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.02526420
17	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.98933105
18	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.90123682
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88093805
20	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.87510878
21	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.82991911
22	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.76484633
23	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.74520882
24	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.71856139
25	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.71180148
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.68277753
27	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.66402742
28	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.66402742
29	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.64412811
30	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.64184376
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.63751742
32	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.63298084
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.63073225
34	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.59344177
35	VDR_22108803_ChIP-Seq_LS180_Human	1.58684196
36	XRN2_22483619_ChIP-Seq_HELA_Human	1.57646771
37	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.57177075
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.56444984
39	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.53126162
40	RNF2_27304074_Chip-Seq_NSC_Mouse	1.52490617
41	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.51355490
42	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.51012657
43	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.40943006
44	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.39049789
45	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.38625454
46	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37564919
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.37396345
48	ZNF274_21170338_ChIP-Seq_K562_Hela	1.35326692
49	CTCF_27219007_Chip-Seq_Bcells_Human	1.35070077
50	SA1_27219007_Chip-Seq_Bcells_Human	1.33363890
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33129009
52	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.32075697
53	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.27664333
54	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.27379310
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.27075168
56	TP53_22573176_ChIP-Seq_HFKS_Human	1.25116983
57	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.25064977
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23426079
59	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22471337
60	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.21297026
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.20550382
62	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19815747
63	NANOG_20526341_ChIP-Seq_ESCs_Human	1.19653928
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.18917540
65	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16854592
66	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.16113415
67	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.15173132
68	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14141324
69	NCOR_22424771_ChIP-Seq_293T_Human	1.13002383
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12527930
71	E2F1_20622854_ChIP-Seq_HELA_Human	1.12384812
72	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.11593510
73	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.11326059
74	BCL6_27268052_Chip-Seq_Bcells_Human	1.10342728
75	ERA_21632823_ChIP-Seq_H3396_Human	1.10018359
76	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.09976070
77	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.07772410
78	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07288106
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06943221
80	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.06758565
81	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.06569709
82	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.05226080
83	MYC_18940864_ChIP-ChIP_HL60_Human	1.04900003
84	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.01584482
85	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00836446
86	P68_20966046_ChIP-Seq_HELA_Human	1.00119540
87	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.99478851
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.97204944
89	SOX2_21211035_ChIP-Seq_LN229_Human	0.93728312
90	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92676433
91	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.91367858
92	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.90895882
93	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89687544
94	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.88633706
95	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87972107
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.87711166
97	P53_21459846_ChIP-Seq_SAOS-2_Human	0.87323988
98	MYC_19829295_ChIP-Seq_ESCs_Human	0.86400306
99	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.85338882
100	FOXP3_21729870_ChIP-Seq_TREG_Human	0.85156127

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	8.19297133
2	MP0006292_abnormal_olfactory_placode	4.83184166
3	MP0002163_abnormal_gland_morphology	3.12585683
4	MP0002837_dystrophic_cardiac_calcinosis	2.81118391
5	MP0003646_muscle_fatigue	2.70206228
6	MP0002638_abnormal_pupillary_reflex	2.52439856
7	MP0003787_abnormal_imprinting	2.46015638
8	MP0002653_abnormal_ependyma_morphology	2.17620991
9	MP0005623_abnormal_meninges_morphology	2.08788221
10	MP0003121_genomic_imprinting	2.04284840
11	MP0003123_paternal_imprinting	2.03890749
12	MP0003122_maternal_imprinting	2.03393532
13	MP0008789_abnormal_olfactory_epithelium	2.02716199
14	MP0005377_hearing/vestibular/ear_phenot	2.00945684
15	MP0003878_abnormal_ear_physiology	2.00945684
16	MP0006276_abnormal_autonomic_nervous	1.82233858
17	MP0005379_endocrine/exocrine_gland_phen	1.74942022
18	MP0004142_abnormal_muscle_tone	1.74422893
19	MP0001529_abnormal_vocalization	1.66447242
20	MP0005394_taste/olfaction_phenotype	1.66322716
21	MP0005499_abnormal_olfactory_system	1.66322716
22	MP0004145_abnormal_muscle_electrophysio	1.63766698
23	MP0002938_white_spotting	1.59911995
24	MP0000049_abnormal_middle_ear	1.58160382
25	MP0003879_abnormal_hair_cell	1.49375523
26	MP0002234_abnormal_pharynx_morphology	1.45752523
27	MP0003880_abnormal_central_pattern	1.44389072
28	MP0005551_abnormal_eye_electrophysiolog	1.42026544
29	MP0001986_abnormal_taste_sensitivity	1.41985478
30	MP0002160_abnormal_reproductive_system	1.39862493
31	MP0001905_abnormal_dopamine_level	1.39003491
32	MP0004885_abnormal_endolymph	1.34582534
33	MP0000778_abnormal_nervous_system	1.30904733
34	MP0004858_abnormal_nervous_system	1.30274242
35	MP0003011_delayed_dark_adaptation	1.25204831
36	MP0004147_increased_porphyrin_level	1.22550462
37	MP0002095_abnormal_skin_pigmentation	1.22398612
38	MP0000631_abnormal_neuroendocrine_gland	1.22375938
39	MP0001293_anophthalmia	1.20221673
40	MP0005389_reproductive_system_phenotype	1.19858435
41	MP0002272_abnormal_nervous_system	1.17838070
42	MP0002822_catalepsy	1.15113152
43	MP0005195_abnormal_posterior_eye	1.14990431
44	MP0008775_abnormal_heart_ventricle	1.11146969
45	MP0000678_abnormal_parathyroid_gland	1.08532396
46	MP0005423_abnormal_somatic_nervous	1.08202067
47	MP0005646_abnormal_pituitary_gland	1.07628879
48	MP0006072_abnormal_retinal_apoptosis	1.06921024
49	MP0002736_abnormal_nociception_after	1.04520634
50	MP0000750_abnormal_muscle_regeneration	1.04476440
51	MP0003186_abnormal_redox_activity	1.04106433
52	MP0009745_abnormal_behavioral_response	1.02504464
53	MP0002752_abnormal_somatic_nervous	1.01814204
54	MP0000026_abnormal_inner_ear	1.00676095
55	MP0004133_heterotaxia	1.00270022
56	MP0008877_abnormal_DNA_methylation	0.99675444
57	MP0009046_muscle_twitch	0.99600109
58	MP0005671_abnormal_response_to	0.99271119
59	MP0001968_abnormal_touch/_nociception	0.97436913
60	MP0004130_abnormal_muscle_cell	0.96257634
61	MP0001485_abnormal_pinna_reflex	0.95463591
62	MP0009250_abnormal_appendicular_skeleto	0.94379703
63	MP0001919_abnormal_reproductive_system	0.93338051
64	MP0002184_abnormal_innervation	0.92470951
65	MP0008872_abnormal_physiological_respon	0.91871785
66	MP0003938_abnormal_ear_development	0.90497254
67	MP0002557_abnormal_social/conspecific_i	0.90238852
68	MP0000955_abnormal_spinal_cord	0.89827195
69	MP0003136_yellow_coat_color	0.88757503
70	MP0009384_cardiac_valve_regurgitation	0.87426705
71	MP0002572_abnormal_emotion/affect_behav	0.86077268
72	MP0010030_abnormal_orbit_morphology	0.84724847
73	MP0002102_abnormal_ear_morphology	0.84599402
74	MP0001440_abnormal_grooming_behavior	0.82092965
75	MP0001970_abnormal_pain_threshold	0.81644250
76	MP0001286_abnormal_eye_development	0.81504612
77	MP0002233_abnormal_nose_morphology	0.81271432
78	MP0001348_abnormal_lacrimal_gland	0.81004597
79	MP0002249_abnormal_larynx_morphology	0.80473274
80	MP0008875_abnormal_xenobiotic_pharmacok	0.80352759
81	MP0002876_abnormal_thyroid_physiology	0.80304406
82	MP0000372_irregular_coat_pigmentation	0.79543959
83	MP0003755_abnormal_palate_morphology	0.78825610
84	MP0004742_abnormal_vestibular_system	0.75717666
85	MP0009053_abnormal_anal_canal	0.75442839
86	MP0003942_abnormal_urinary_system	0.74070010
87	MP0002063_abnormal_learning/memory/cond	0.73645612
88	MP0001663_abnormal_digestive_system	0.72525712
89	MP0002067_abnormal_sensory_capabilities	0.70805474
90	MP0009765_abnormal_xenobiotic_induced	0.70465388
91	MP0002116_abnormal_craniofacial_bone	0.70360838
92	MP0002733_abnormal_thermal_nociception	0.70300856
93	MP0001727_abnormal_embryo_implantation	0.69741582
94	MP0002882_abnormal_neuron_morphology	0.69119899
95	MP0001873_stomach_inflammation	0.68609208
96	MP0003119_abnormal_digestive_system	0.67721595
97	MP0001963_abnormal_hearing_physiology	0.67609347
98	MP0006082_CNS_inflammation	0.67049962
99	MP0001486_abnormal_startle_reflex	0.64874038
100	MP0000762_abnormal_tongue_morphology	0.64647623

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of cells of the erythroid lineage (HP:0012130)	5.32285838
2	Reticulocytopenia (HP:0001896)	4.93713249
3	Acute necrotizing encephalopathy (HP:0006965)	4.69928601
4	Pallor (HP:0000980)	4.36313214
5	Abnormal number of erythroid precursors (HP:0012131)	4.18484959
6	Macrocytic anemia (HP:0001972)	4.17407994
7	Abnormal mitochondria in muscle tissue (HP:0008316)	4.16327807
8	Type II lissencephaly (HP:0007260)	4.13914043
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.87347695
10	Hypoplasia of the pons (HP:0012110)	3.85473922
11	Mitochondrial inheritance (HP:0001427)	3.81827843
12	Progressive macrocephaly (HP:0004481)	3.80216199
13	Acute encephalopathy (HP:0006846)	3.79788469
14	Cerebellar dysplasia (HP:0007033)	3.74865959
15	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.65756282
16	Abnormality of the pons (HP:0007361)	3.35734582
17	Increased CSF lactate (HP:0002490)	3.23183671
18	Retinal atrophy (HP:0001105)	3.20553963
19	Retinal dysplasia (HP:0007973)	3.13084347
20	Abnormality of midbrain morphology (HP:0002418)	3.09974474
21	Molar tooth sign on MRI (HP:0002419)	3.09974474
22	Increased hepatocellular lipid droplets (HP:0006565)	3.06063826
23	Lipid accumulation in hepatocytes (HP:0006561)	2.95901126
24	Cerebral edema (HP:0002181)	2.94946805
25	Abolished electroretinogram (ERG) (HP:0000550)	2.86020380
26	Hepatocellular necrosis (HP:0001404)	2.85240063
27	Pancreatic fibrosis (HP:0100732)	2.83209004
28	Septo-optic dysplasia (HP:0100842)	2.82416687
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.82350000
30	Abnormal rod and cone electroretinograms (HP:0008323)	2.79361122
31	Dyskinesia (HP:0100660)	2.74035704
32	Renal Fanconi syndrome (HP:0001994)	2.71725484
33	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.56816398
34	Absent/shortened dynein arms (HP:0200106)	2.56816398
35	Decreased muscle mass (HP:0003199)	2.55653540
36	Myokymia (HP:0002411)	2.54524846
37	3-Methylglutaconic aciduria (HP:0003535)	2.50720636
38	Optic disc pallor (HP:0000543)	2.50376839
39	Increased intramyocellular lipid droplets (HP:0012240)	2.47815875
40	Pendular nystagmus (HP:0012043)	2.46403140
41	Stenosis of the external auditory canal (HP:0000402)	2.44685257
42	Hyperglycinemia (HP:0002154)	2.39626389
43	True hermaphroditism (HP:0010459)	2.36676218
44	Chronic hepatic failure (HP:0100626)	2.35989119
45	Hepatic necrosis (HP:0002605)	2.35600640
46	Asplenia (HP:0001746)	2.35472115
47	Absent thumb (HP:0009777)	2.35046188
48	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.33729767
49	Medial flaring of the eyebrow (HP:0010747)	2.33068177
50	Pancreatic cysts (HP:0001737)	2.30566298
51	Partial duplication of thumb phalanx (HP:0009944)	2.21004922
52	Sclerocornea (HP:0000647)	2.20793176
53	Abnormal hemoglobin (HP:0011902)	2.17623470
54	Partial duplication of the phalanx of hand (HP:0009999)	2.17573925
55	Increased muscle lipid content (HP:0009058)	2.15453781
56	Congenital stationary night blindness (HP:0007642)	2.14303131
57	Adrenal hypoplasia (HP:0000835)	2.14253636
58	Exertional dyspnea (HP:0002875)	2.11819611
59	Rib fusion (HP:0000902)	2.09786757
60	Anencephaly (HP:0002323)	2.09630979
61	Hyperthyroidism (HP:0000836)	2.08891211
62	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.06286930
63	Depressed nasal ridge (HP:0000457)	2.03121529
64	Severe muscular hypotonia (HP:0006829)	2.02004861
65	Leukodystrophy (HP:0002415)	1.99294187
66	Abnormality of DNA repair (HP:0003254)	1.96940454
67	Nephronophthisis (HP:0000090)	1.96897845
68	Constricted visual fields (HP:0001133)	1.91894975
69	Lissencephaly (HP:0001339)	1.91768468
70	Decreased central vision (HP:0007663)	1.88244359
71	Respiratory failure (HP:0002878)	1.88131730
72	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87873044
73	Abnormal respiratory epithelium morphology (HP:0012253)	1.87721714
74	Abnormal respiratory motile cilium morphology (HP:0005938)	1.87721714
75	Buphthalmos (HP:0000557)	1.87162830
76	Diastasis recti (HP:0001540)	1.83956714
77	Poor suck (HP:0002033)	1.82762956
78	Hyperphosphaturia (HP:0003109)	1.82698048
79	Abnormality of renal resorption (HP:0011038)	1.81261028
80	Short femoral neck (HP:0100864)	1.79705813
81	Holoprosencephaly (HP:0001360)	1.78441374
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77429251
83	Cystic liver disease (HP:0006706)	1.76550485
84	Renal dysplasia (HP:0000110)	1.75630717
85	Hypoplasia of the ulna (HP:0003022)	1.75425418
86	Maternal diabetes (HP:0009800)	1.75384152
87	Lactic acidosis (HP:0003128)	1.74917758
88	Abnormal drinking behavior (HP:0030082)	1.73219659
89	Polydipsia (HP:0001959)	1.73219659
90	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.69358234
91	Colon cancer (HP:0003003)	1.68855371
92	Hypoplasia of the radius (HP:0002984)	1.68481787
93	Abnormality of the renal medulla (HP:0100957)	1.68427624
94	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.67923971
95	Anophthalmia (HP:0000528)	1.67589872
96	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.67051896
97	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.67051896
98	Congenital, generalized hypertrichosis (HP:0004540)	1.66950641
99	Concave nail (HP:0001598)	1.66643746
100	Acanthocytosis (HP:0001927)	1.65932078

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.80792087
2	PASK	3.11871941
3	NME2	3.09369991
4	MARK3	2.63729527
5	CDK19	2.38755527
6	PIK3CA	2.36654434
7	TXK	2.24171397
8	STK16	2.17920341
9	LRRK2	2.08720775
10	DYRK2	2.04904379
11	STK11	1.95732452
12	WNK4	1.94671673
13	GRK1	1.81483250
14	CAMKK1	1.76309979
15	ADRBK2	1.69993711
16	LIMK1	1.66441774
17	MAP4K1	1.64854774
18	MAP4K2	1.61871388
19	EPHA4	1.55323730
20	KIT	1.51112264
21	TIE1	1.49780152
22	PIM1	1.45754014
23	MAP3K11	1.44295283
24	MAP2K7	1.40012728
25	WNK3	1.33522116
26	NTRK2	1.28935188
27	CDC7	1.28589566
28	STK10	1.28066571
29	PRKCG	1.27532464
30	EPHB2	1.24527508
31	PIM2	1.21719456
32	TYRO3	1.20813132
33	FRK	1.20796828
34	CAMKK2	1.12753935
35	ABL2	1.12189036
36	CAMK1	1.10458902
37	INSRR	1.06832805
38	TEC	1.00129830
39	OBSCN	0.97636288
40	PDK2	0.97494640
41	DAPK3	0.96256713
42	AURKA	0.94805665
43	MUSK	0.93700254
44	PKN1	0.93370923
45	IKBKB	0.91553127
46	MAP3K4	0.90045874
47	BMPR1B	0.86921301
48	PRKCQ	0.84979655
49	BRAF	0.84442903
50	MINK1	0.84139381
51	PLK4	0.83427921
52	PRKACA	0.82551666
53	ILK	0.80512268
54	RPS6KA6	0.78938874
55	ADRBK1	0.78804009
56	MYLK	0.78260019
57	MAPK15	0.77376135
58	PINK1	0.77186821
59	RPS6KA5	0.76599695
60	ARAF	0.75949574
61	PRKCH	0.75551122
62	CSNK2A2	0.74895952
63	SIK2	0.73737369
64	LCK	0.72079331
65	BTK	0.72051563
66	DYRK1B	0.70263268
67	MAP3K13	0.68798972
68	NEK2	0.68586418
69	TLK1	0.64684012
70	SGK223	0.64653662
71	SGK494	0.64653662
72	NTRK3	0.64540028
73	PRKCD	0.61955737
74	CSNK2A1	0.59297239
75	RPS6KL1	0.59271531
76	RPS6KC1	0.59271531
77	FES	0.57701309
78	PRKCA	0.57358624
79	DYRK3	0.56976597
80	BRSK1	0.56845830
81	SYK	0.54810140
82	PRKCZ	0.54599637
83	KDR	0.53936092
84	MAPK13	0.53236353
85	AURKB	0.52947736
86	CSNK1A1	0.51044457
87	MARK2	0.49887010
88	OXSR1	0.49102386
89	CASK	0.47441852
90	PLK1	0.45970501
91	PRKACG	0.45825479
92	STK39	0.45775771
93	CDK8	0.45239826
94	CHEK2	0.43992527
95	CAMK2A	0.43503854
96	MAP3K12	0.42863968
97	SGK1	0.40314801
98	DYRK1A	0.39448287
99	MARK1	0.37951962
100	CSNK1E	0.37889984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	8.46315774
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.72955526
3	Parkinsons disease_Homo sapiens_hsa05012	3.90808116
4	Sulfur relay system_Homo sapiens_hsa04122	3.40621779
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.87751753
6	Alzheimers disease_Homo sapiens_hsa05010	2.78928154
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.78679893
8	Huntingtons disease_Homo sapiens_hsa05016	2.77798231
9	Asthma_Homo sapiens_hsa05310	2.18765879
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.86242958
11	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.64100914
12	Phototransduction_Homo sapiens_hsa04744	1.49113804
13	RNA polymerase_Homo sapiens_hsa03020	1.47333802
14	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.40823589
15	Graft-versus-host disease_Homo sapiens_hsa05332	1.40706323
16	Allograft rejection_Homo sapiens_hsa05330	1.40311176
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.35060488
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34769583
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.32102525
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.29652830
21	Protein export_Homo sapiens_hsa03060	1.19190850
22	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17576479
23	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	1.14055753
24	RNA degradation_Homo sapiens_hsa03018	1.10804828
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.04897934
26	Nicotine addiction_Homo sapiens_hsa05033	1.04201038
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03460309
28	Homologous recombination_Homo sapiens_hsa03440	0.99279796
29	Sulfur metabolism_Homo sapiens_hsa00920	0.96855930
30	Olfactory transduction_Homo sapiens_hsa04740	0.96145109
31	Proteasome_Homo sapiens_hsa03050	0.90196972
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.88062285
33	Fat digestion and absorption_Homo sapiens_hsa04975	0.84800671
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.81181209
35	Tryptophan metabolism_Homo sapiens_hsa00380	0.75391254
36	Fanconi anemia pathway_Homo sapiens_hsa03460	0.73892923
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72968035
38	One carbon pool by folate_Homo sapiens_hsa00670	0.71923128
39	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.70161211
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.68822397
41	Tyrosine metabolism_Homo sapiens_hsa00350	0.66910789
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.66548821
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.65866322
44	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65768711
45	Metabolic pathways_Homo sapiens_hsa01100	0.65497175
46	Retinol metabolism_Homo sapiens_hsa00830	0.63322587
47	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.61404965
48	DNA replication_Homo sapiens_hsa03030	0.60359012
49	Insulin secretion_Homo sapiens_hsa04911	0.58631493
50	Morphine addiction_Homo sapiens_hsa05032	0.58456244
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58010149
52	Purine metabolism_Homo sapiens_hsa00230	0.57603353
53	Rheumatoid arthritis_Homo sapiens_hsa05323	0.55576181
54	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.55160041
55	Peroxisome_Homo sapiens_hsa04146	0.54139933
56	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53520052
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.52271751
58	Basal transcription factors_Homo sapiens_hsa03022	0.50495128
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50427068
60	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.49272858
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.47704933
62	Butanoate metabolism_Homo sapiens_hsa00650	0.47444755
63	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47066905
64	Collecting duct acid secretion_Homo sapiens_hsa04966	0.46789875
65	Regulation of autophagy_Homo sapiens_hsa04140	0.45751940
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44989087
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44426730
68	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.43830823
69	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42924741
70	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42421267
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41632251
72	Caffeine metabolism_Homo sapiens_hsa00232	0.40911343
73	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38366291
74	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.37984006
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.37778240
76	GABAergic synapse_Homo sapiens_hsa04727	0.37638550
77	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.37267265
78	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35559317
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35274356
80	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34367544
81	Nucleotide excision repair_Homo sapiens_hsa03420	0.33823337
82	Ether lipid metabolism_Homo sapiens_hsa00565	0.33759432
83	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.33419757
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.33338930
85	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.31824872
86	Serotonergic synapse_Homo sapiens_hsa04726	0.30546355
87	Mismatch repair_Homo sapiens_hsa03430	0.30133326
88	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.29840903
89	Fatty acid degradation_Homo sapiens_hsa00071	0.29617829
90	Primary immunodeficiency_Homo sapiens_hsa05340	0.28393692
91	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.25882266
92	Taste transduction_Homo sapiens_hsa04742	0.25534450
93	Viral myocarditis_Homo sapiens_hsa05416	0.23703245
94	Axon guidance_Homo sapiens_hsa04360	0.22616037
95	Cocaine addiction_Homo sapiens_hsa05030	0.22584098
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.22237264
97	Antigen processing and presentation_Homo sapiens_hsa04612	0.21949050
98	Dopaminergic synapse_Homo sapiens_hsa04728	0.20937719
99	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.20413006
100	Base excision repair_Homo sapiens_hsa03410	0.20272508

RPL36AP43

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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