RPL36AP43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)9.97872063
2ribosomal small subunit assembly (GO:0000028)8.86057111
3translational elongation (GO:0006414)8.33405185
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.27695488
5cotranslational protein targeting to membrane (GO:0006613)8.12794090
6protein targeting to ER (GO:0045047)8.10754761
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.79364993
8cellular protein complex disassembly (GO:0043624)7.61182798
9protein localization to endoplasmic reticulum (GO:0070972)7.61019355
10viral life cycle (GO:0019058)7.51840674
11nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.26691201
12maturation of SSU-rRNA (GO:0030490)7.00076871
13chaperone-mediated protein transport (GO:0072321)6.72761039
14protein complex disassembly (GO:0043241)6.44759882
15translational initiation (GO:0006413)6.23764677
16macromolecular complex disassembly (GO:0032984)6.00646168
17ATP synthesis coupled proton transport (GO:0015986)5.75546103
18energy coupled proton transport, down electrochemical gradient (GO:0015985)5.75546103
19protein targeting to membrane (GO:0006612)5.68836832
20ribosomal large subunit biogenesis (GO:0042273)5.33694254
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97689315
22nuclear-transcribed mRNA catabolic process (GO:0000956)4.94661787
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.84703133
24translation (GO:0006412)4.82086449
25mRNA catabolic process (GO:0006402)4.61966965
26substrate-independent telencephalic tangential migration (GO:0021826)4.47315579
27substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.47315579
28ribonucleoprotein complex biogenesis (GO:0022613)4.30831500
29cellular component biogenesis (GO:0044085)4.20088711
30respiratory electron transport chain (GO:0022904)4.13178908
31behavioral response to nicotine (GO:0035095)4.12969369
32RNA catabolic process (GO:0006401)4.12911724
33electron transport chain (GO:0022900)4.05592922
34protein complex biogenesis (GO:0070271)3.97752706
35establishment of protein localization to membrane (GO:0090150)3.93738796
36tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.91008649
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.91008649
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.87793223
39NADH dehydrogenase complex assembly (GO:0010257)3.87793223
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.87793223
41cell proliferation in forebrain (GO:0021846)3.85042059
42protein targeting (GO:0006605)3.61481610
43mitochondrial respiratory chain complex assembly (GO:0033108)3.60843112
44pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.50896180
45ATP biosynthetic process (GO:0006754)3.48271992
46protein neddylation (GO:0045116)3.45362458
47CTP biosynthetic process (GO:0006241)3.41357367
48CTP metabolic process (GO:0046036)3.41357367
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.40925626
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.38719909
51ribonucleoside triphosphate biosynthetic process (GO:0009201)3.34421717
52ncRNA 3-end processing (GO:0043628)3.31735474
53purine nucleoside triphosphate biosynthetic process (GO:0009145)3.30263222
54establishment of protein localization to organelle (GO:0072594)3.26457454
55GTP biosynthetic process (GO:0006183)3.17662131
56protein localization to membrane (GO:0072657)3.14297442
57DNA deamination (GO:0045006)3.07787618
58pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05182247
59pattern specification involved in kidney development (GO:0061004)3.05139906
60pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03896906
61pyrimidine nucleotide catabolic process (GO:0006244)3.03695498
62pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.03484178
63exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.00808873
64cardiovascular system development (GO:0072358)2.99757888
65activation of MAPKKK activity (GO:0000185)2.99138171
66deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.95615235
67nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92862969
68forebrain morphogenesis (GO:0048853)2.86783506
69positive regulation of T cell apoptotic process (GO:0070234)2.84929442
70pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.82353498
71nucleoside triphosphate biosynthetic process (GO:0009142)2.81330826
72hydrogen ion transmembrane transport (GO:1902600)2.78765063
73regulation of cellular respiration (GO:0043457)2.75563641
74segment specification (GO:0007379)2.74472811
75neuron fate determination (GO:0048664)2.71377485
76positive regulation of respiratory burst (GO:0060267)2.71233449
77UTP biosynthetic process (GO:0006228)2.69396214
78spinal cord association neuron differentiation (GO:0021527)2.68286293
79epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65249927
80intracellular protein transmembrane import (GO:0044743)2.59010086
81somite development (GO:0061053)2.57565313
82nonmotile primary cilium assembly (GO:0035058)2.54897514
83negative regulation of appetite (GO:0032099)2.51734751
84negative regulation of response to food (GO:0032096)2.51734751
85rRNA metabolic process (GO:0016072)2.50378781
86positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49153341
87axon ensheathment in central nervous system (GO:0032291)2.44657054
88central nervous system myelination (GO:0022010)2.44657054
89hypothalamus development (GO:0021854)2.44652375
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.44003265
91proton transport (GO:0015992)2.43990382
92tongue development (GO:0043586)2.43626004
93protein polyglutamylation (GO:0018095)2.41075783
94UTP metabolic process (GO:0046051)2.40970486
95rRNA processing (GO:0006364)2.40501744
96nucleotide salvage (GO:0043173)2.39612804
97hydrogen transport (GO:0006818)2.36839438
98positive regulation of potassium ion transmembrane transport (GO:1901381)2.33783487
99viral transcription (GO:0019083)10.4664596
100ribosomal small subunit biogenesis (GO:0042274)10.4621870

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.45953331
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.74201903
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.41679481
4GABP_17652178_ChIP-ChIP_JURKAT_Human2.79356401
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46015909
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.36104893
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.29849930
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.22600288
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15451914
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.14789328
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12890282
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.06442915
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.04561248
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04127951
15SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03332814
16NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.02526420
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98933105
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90123682
19MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88093805
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87510878
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.82991911
22TP53_20018659_ChIP-ChIP_R1E_Mouse1.76484633
23CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.74520882
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.71856139
25POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.71180148
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68277753
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66402742
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66402742
29CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.64412811
30KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.64184376
31IRF1_19129219_ChIP-ChIP_H3396_Human1.63751742
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.63298084
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.63073225
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.59344177
35VDR_22108803_ChIP-Seq_LS180_Human1.58684196
36XRN2_22483619_ChIP-Seq_HELA_Human1.57646771
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57177075
38JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56444984
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53126162
40RNF2_27304074_Chip-Seq_NSC_Mouse1.52490617
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51355490
42SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.51012657
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40943006
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.39049789
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38625454
46REST_21632747_ChIP-Seq_MESCs_Mouse1.37564919
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37396345
48ZNF274_21170338_ChIP-Seq_K562_Hela1.35326692
49CTCF_27219007_Chip-Seq_Bcells_Human1.35070077
50SA1_27219007_Chip-Seq_Bcells_Human1.33363890
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33129009
52SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.32075697
53RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.27664333
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27379310
55TAF2_19829295_ChIP-Seq_ESCs_Human1.27075168
56TP53_22573176_ChIP-Seq_HFKS_Human1.25116983
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.25064977
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23426079
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22471337
60RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21297026
61TTF2_22483619_ChIP-Seq_HELA_Human1.20550382
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19815747
63NANOG_20526341_ChIP-Seq_ESCs_Human1.19653928
64RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18917540
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16854592
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16113415
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.15173132
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.14141324
69NCOR_22424771_ChIP-Seq_293T_Human1.13002383
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12527930
71E2F1_20622854_ChIP-Seq_HELA_Human1.12384812
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.11593510
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11326059
74BCL6_27268052_Chip-Seq_Bcells_Human1.10342728
75ERA_21632823_ChIP-Seq_H3396_Human1.10018359
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09976070
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.07772410
78CTCF_20526341_ChIP-Seq_ESCs_Human1.07288106
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.06943221
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.06758565
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06569709
82CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05226080
83MYC_18940864_ChIP-ChIP_HL60_Human1.04900003
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01584482
85GATA3_21878914_ChIP-Seq_MCF-7_Human1.00836446
86P68_20966046_ChIP-Seq_HELA_Human1.00119540
87FOXP1_21924763_ChIP-Seq_HESCs_Human0.99478851
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.97204944
89SOX2_21211035_ChIP-Seq_LN229_Human0.93728312
90FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92676433
91PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91367858
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.90895882
93CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89687544
94THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88633706
95P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87972107
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.87711166
97P53_21459846_ChIP-Seq_SAOS-2_Human0.87323988
98MYC_19829295_ChIP-Seq_ESCs_Human0.86400306
99MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85338882
100FOXP3_21729870_ChIP-Seq_TREG_Human0.85156127

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.19297133
2MP0006292_abnormal_olfactory_placode4.83184166
3MP0002163_abnormal_gland_morphology3.12585683
4MP0002837_dystrophic_cardiac_calcinosis2.81118391
5MP0003646_muscle_fatigue2.70206228
6MP0002638_abnormal_pupillary_reflex2.52439856
7MP0003787_abnormal_imprinting2.46015638
8MP0002653_abnormal_ependyma_morphology2.17620991
9MP0005623_abnormal_meninges_morphology2.08788221
10MP0003121_genomic_imprinting2.04284840
11MP0003123_paternal_imprinting2.03890749
12MP0003122_maternal_imprinting2.03393532
13MP0008789_abnormal_olfactory_epithelium2.02716199
14MP0005377_hearing/vestibular/ear_phenot2.00945684
15MP0003878_abnormal_ear_physiology2.00945684
16MP0006276_abnormal_autonomic_nervous1.82233858
17MP0005379_endocrine/exocrine_gland_phen1.74942022
18MP0004142_abnormal_muscle_tone1.74422893
19MP0001529_abnormal_vocalization1.66447242
20MP0005499_abnormal_olfactory_system1.66322716
21MP0005394_taste/olfaction_phenotype1.66322716
22MP0004145_abnormal_muscle_electrophysio1.63766698
23MP0002938_white_spotting1.59911995
24MP0000049_abnormal_middle_ear1.58160382
25MP0003879_abnormal_hair_cell1.49375523
26MP0002234_abnormal_pharynx_morphology1.45752523
27MP0003880_abnormal_central_pattern1.44389072
28MP0005551_abnormal_eye_electrophysiolog1.42026544
29MP0001986_abnormal_taste_sensitivity1.41985478
30MP0002160_abnormal_reproductive_system1.39862493
31MP0001905_abnormal_dopamine_level1.39003491
32MP0004885_abnormal_endolymph1.34582534
33MP0000778_abnormal_nervous_system1.30904733
34MP0004858_abnormal_nervous_system1.30274242
35MP0003011_delayed_dark_adaptation1.25204831
36MP0004147_increased_porphyrin_level1.22550462
37MP0002095_abnormal_skin_pigmentation1.22398612
38MP0000631_abnormal_neuroendocrine_gland1.22375938
39MP0001293_anophthalmia1.20221673
40MP0005389_reproductive_system_phenotype1.19858435
41MP0002272_abnormal_nervous_system1.17838070
42MP0002822_catalepsy1.15113152
43MP0005195_abnormal_posterior_eye1.14990431
44MP0008775_abnormal_heart_ventricle1.11146969
45MP0000678_abnormal_parathyroid_gland1.08532396
46MP0005423_abnormal_somatic_nervous1.08202067
47MP0005646_abnormal_pituitary_gland1.07628879
48MP0006072_abnormal_retinal_apoptosis1.06921024
49MP0002736_abnormal_nociception_after1.04520634
50MP0000750_abnormal_muscle_regeneration1.04476440
51MP0003186_abnormal_redox_activity1.04106433
52MP0009745_abnormal_behavioral_response1.02504464
53MP0002752_abnormal_somatic_nervous1.01814204
54MP0000026_abnormal_inner_ear1.00676095
55MP0004133_heterotaxia1.00270022
56MP0008877_abnormal_DNA_methylation0.99675444
57MP0009046_muscle_twitch0.99600109
58MP0005671_abnormal_response_to0.99271119
59MP0001968_abnormal_touch/_nociception0.97436913
60MP0004130_abnormal_muscle_cell0.96257634
61MP0001485_abnormal_pinna_reflex0.95463591
62MP0009250_abnormal_appendicular_skeleto0.94379703
63MP0001919_abnormal_reproductive_system0.93338051
64MP0002184_abnormal_innervation0.92470951
65MP0008872_abnormal_physiological_respon0.91871785
66MP0003938_abnormal_ear_development0.90497254
67MP0002557_abnormal_social/conspecific_i0.90238852
68MP0000955_abnormal_spinal_cord0.89827195
69MP0003136_yellow_coat_color0.88757503
70MP0009384_cardiac_valve_regurgitation0.87426705
71MP0002572_abnormal_emotion/affect_behav0.86077268
72MP0010030_abnormal_orbit_morphology0.84724847
73MP0002102_abnormal_ear_morphology0.84599402
74MP0001440_abnormal_grooming_behavior0.82092965
75MP0001970_abnormal_pain_threshold0.81644250
76MP0001286_abnormal_eye_development0.81504612
77MP0002233_abnormal_nose_morphology0.81271432
78MP0001348_abnormal_lacrimal_gland0.81004597
79MP0002249_abnormal_larynx_morphology0.80473274
80MP0008875_abnormal_xenobiotic_pharmacok0.80352759
81MP0002876_abnormal_thyroid_physiology0.80304406
82MP0000372_irregular_coat_pigmentation0.79543959
83MP0003755_abnormal_palate_morphology0.78825610
84MP0004742_abnormal_vestibular_system0.75717666
85MP0009053_abnormal_anal_canal0.75442839
86MP0003942_abnormal_urinary_system0.74070010
87MP0002063_abnormal_learning/memory/cond0.73645612
88MP0001663_abnormal_digestive_system0.72525712
89MP0002067_abnormal_sensory_capabilities0.70805474
90MP0009765_abnormal_xenobiotic_induced0.70465388
91MP0002116_abnormal_craniofacial_bone0.70360838
92MP0002733_abnormal_thermal_nociception0.70300856
93MP0001727_abnormal_embryo_implantation0.69741582
94MP0002882_abnormal_neuron_morphology0.69119899
95MP0001873_stomach_inflammation0.68609208
96MP0003119_abnormal_digestive_system0.67721595
97MP0001963_abnormal_hearing_physiology0.67609347
98MP0006082_CNS_inflammation0.67049962
99MP0001486_abnormal_startle_reflex0.64874038
100MP0000762_abnormal_tongue_morphology0.64647623

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.32285838
2Reticulocytopenia (HP:0001896)4.93713249
3Acute necrotizing encephalopathy (HP:0006965)4.69928601
4Pallor (HP:0000980)4.36313214
5Abnormal number of erythroid precursors (HP:0012131)4.18484959
6Macrocytic anemia (HP:0001972)4.17407994
7Abnormal mitochondria in muscle tissue (HP:0008316)4.16327807
8Type II lissencephaly (HP:0007260)4.13914043
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.87347695
10Hypoplasia of the pons (HP:0012110)3.85473922
11Mitochondrial inheritance (HP:0001427)3.81827843
12Progressive macrocephaly (HP:0004481)3.80216199
13Acute encephalopathy (HP:0006846)3.79788469
14Cerebellar dysplasia (HP:0007033)3.74865959
15Decreased electroretinogram (ERG) amplitude (HP:0000654)3.65756282
16Abnormality of the pons (HP:0007361)3.35734582
17Increased CSF lactate (HP:0002490)3.23183671
18Retinal atrophy (HP:0001105)3.20553963
19Retinal dysplasia (HP:0007973)3.13084347
20Molar tooth sign on MRI (HP:0002419)3.09974474
21Abnormality of midbrain morphology (HP:0002418)3.09974474
22Increased hepatocellular lipid droplets (HP:0006565)3.06063826
23Lipid accumulation in hepatocytes (HP:0006561)2.95901126
24Cerebral edema (HP:0002181)2.94946805
25Abolished electroretinogram (ERG) (HP:0000550)2.86020380
26Hepatocellular necrosis (HP:0001404)2.85240063
27Pancreatic fibrosis (HP:0100732)2.83209004
28Septo-optic dysplasia (HP:0100842)2.82416687
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82350000
30Abnormal rod and cone electroretinograms (HP:0008323)2.79361122
31Dyskinesia (HP:0100660)2.74035704
32Renal Fanconi syndrome (HP:0001994)2.71725484
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.56816398
34Absent/shortened dynein arms (HP:0200106)2.56816398
35Decreased muscle mass (HP:0003199)2.55653540
36Myokymia (HP:0002411)2.54524846
373-Methylglutaconic aciduria (HP:0003535)2.50720636
38Optic disc pallor (HP:0000543)2.50376839
39Increased intramyocellular lipid droplets (HP:0012240)2.47815875
40Pendular nystagmus (HP:0012043)2.46403140
41Stenosis of the external auditory canal (HP:0000402)2.44685257
42Hyperglycinemia (HP:0002154)2.39626389
43True hermaphroditism (HP:0010459)2.36676218
44Chronic hepatic failure (HP:0100626)2.35989119
45Hepatic necrosis (HP:0002605)2.35600640
46Asplenia (HP:0001746)2.35472115
47Absent thumb (HP:0009777)2.35046188
48Aplasia/Hypoplasia of the spleen (HP:0010451)2.33729767
49Medial flaring of the eyebrow (HP:0010747)2.33068177
50Pancreatic cysts (HP:0001737)2.30566298
51Partial duplication of thumb phalanx (HP:0009944)2.21004922
52Sclerocornea (HP:0000647)2.20793176
53Abnormal hemoglobin (HP:0011902)2.17623470
54Partial duplication of the phalanx of hand (HP:0009999)2.17573925
55Increased muscle lipid content (HP:0009058)2.15453781
56Congenital stationary night blindness (HP:0007642)2.14303131
57Adrenal hypoplasia (HP:0000835)2.14253636
58Exertional dyspnea (HP:0002875)2.11819611
59Rib fusion (HP:0000902)2.09786757
60Anencephaly (HP:0002323)2.09630979
61Hyperthyroidism (HP:0000836)2.08891211
62Aplasia/Hypoplasia affecting the retina (HP:0008061)2.06286930
63Depressed nasal ridge (HP:0000457)2.03121529
64Severe muscular hypotonia (HP:0006829)2.02004861
65Leukodystrophy (HP:0002415)1.99294187
66Abnormality of DNA repair (HP:0003254)1.96940454
67Nephronophthisis (HP:0000090)1.96897845
68Constricted visual fields (HP:0001133)1.91894975
69Lissencephaly (HP:0001339)1.91768468
70Decreased central vision (HP:0007663)1.88244359
71Respiratory failure (HP:0002878)1.88131730
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.87873044
73Abnormal respiratory motile cilium morphology (HP:0005938)1.87721714
74Abnormal respiratory epithelium morphology (HP:0012253)1.87721714
75Buphthalmos (HP:0000557)1.87162830
76Diastasis recti (HP:0001540)1.83956714
77Poor suck (HP:0002033)1.82762956
78Hyperphosphaturia (HP:0003109)1.82698048
79Abnormality of renal resorption (HP:0011038)1.81261028
80Short femoral neck (HP:0100864)1.79705813
81Holoprosencephaly (HP:0001360)1.78441374
82Abnormal respiratory motile cilium physiology (HP:0012261)1.77429251
83Cystic liver disease (HP:0006706)1.76550485
84Renal dysplasia (HP:0000110)1.75630717
85Hypoplasia of the ulna (HP:0003022)1.75425418
86Maternal diabetes (HP:0009800)1.75384152
87Lactic acidosis (HP:0003128)1.74917758
88Polydipsia (HP:0001959)1.73219659
89Abnormal drinking behavior (HP:0030082)1.73219659
90Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.69358234
91Colon cancer (HP:0003003)1.68855371
92Hypoplasia of the radius (HP:0002984)1.68481787
93Abnormality of the renal medulla (HP:0100957)1.68427624
94Abnormality of the phalanges of the 5th finger (HP:0004213)1.67923971
95Anophthalmia (HP:0000528)1.67589872
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67051896
97Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67051896
98Congenital, generalized hypertrichosis (HP:0004540)1.66950641
99Concave nail (HP:0001598)1.66643746
100Acanthocytosis (HP:0001927)1.65932078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK3.80792087
2PASK3.11871941
3NME23.09369991
4MARK32.63729527
5CDK192.38755527
6PIK3CA2.36654434
7TXK2.24171397
8STK162.17920341
9LRRK22.08720775
10DYRK22.04904379
11STK111.95732452
12WNK41.94671673
13GRK11.81483250
14CAMKK11.76309979
15ADRBK21.69993711
16LIMK11.66441774
17MAP4K11.64854774
18MAP4K21.61871388
19EPHA41.55323730
20KIT1.51112264
21TIE11.49780152
22PIM11.45754014
23MAP3K111.44295283
24MAP2K71.40012728
25WNK31.33522116
26NTRK21.28935188
27CDC71.28589566
28STK101.28066571
29PRKCG1.27532464
30EPHB21.24527508
31PIM21.21719456
32TYRO31.20813132
33FRK1.20796828
34CAMKK21.12753935
35ABL21.12189036
36CAMK11.10458902
37INSRR1.06832805
38TEC1.00129830
39OBSCN0.97636288
40PDK20.97494640
41DAPK30.96256713
42AURKA0.94805665
43MUSK0.93700254
44PKN10.93370923
45IKBKB0.91553127
46MAP3K40.90045874
47BMPR1B0.86921301
48PRKCQ0.84979655
49BRAF0.84442903
50MINK10.84139381
51PLK40.83427921
52PRKACA0.82551666
53ILK0.80512268
54RPS6KA60.78938874
55ADRBK10.78804009
56MYLK0.78260019
57MAPK150.77376135
58PINK10.77186821
59RPS6KA50.76599695
60ARAF0.75949574
61PRKCH0.75551122
62CSNK2A20.74895952
63SIK20.73737369
64LCK0.72079331
65BTK0.72051563
66DYRK1B0.70263268
67MAP3K130.68798972
68NEK20.68586418
69TLK10.64684012
70SGK2230.64653662
71SGK4940.64653662
72NTRK30.64540028
73PRKCD0.61955737
74CSNK2A10.59297239
75RPS6KL10.59271531
76RPS6KC10.59271531
77FES0.57701309
78PRKCA0.57358624
79DYRK30.56976597
80BRSK10.56845830
81SYK0.54810140
82PRKCZ0.54599637
83KDR0.53936092
84MAPK130.53236353
85AURKB0.52947736
86CSNK1A10.51044457
87MARK20.49887010
88OXSR10.49102386
89CASK0.47441852
90PLK10.45970501
91PRKACG0.45825479
92STK390.45775771
93CDK80.45239826
94CHEK20.43992527
95CAMK2A0.43503854
96MAP3K120.42863968
97SGK10.40314801
98DYRK1A0.39448287
99MARK10.37951962
100CSNK1E0.37889984

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.46315774
2Oxidative phosphorylation_Homo sapiens_hsa001904.72955526
3Parkinsons disease_Homo sapiens_hsa050123.90808116
4Sulfur relay system_Homo sapiens_hsa041223.40621779
5Cardiac muscle contraction_Homo sapiens_hsa042602.87751753
6Alzheimers disease_Homo sapiens_hsa050102.78928154
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.78679893
8Huntingtons disease_Homo sapiens_hsa050162.77798231
9Asthma_Homo sapiens_hsa053102.18765879
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.86242958
11Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.64100914
12Phototransduction_Homo sapiens_hsa047441.49113804
13RNA polymerase_Homo sapiens_hsa030201.47333802
14Autoimmune thyroid disease_Homo sapiens_hsa053201.40823589
15Graft-versus-host disease_Homo sapiens_hsa053321.40706323
16Allograft rejection_Homo sapiens_hsa053301.40311176
17Linoleic acid metabolism_Homo sapiens_hsa005911.35060488
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34769583
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.32102525
20SNARE interactions in vesicular transport_Homo sapiens_hsa041301.29652830
21Protein export_Homo sapiens_hsa030601.19190850
22Pyrimidine metabolism_Homo sapiens_hsa002401.17576479
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14055753
24RNA degradation_Homo sapiens_hsa030181.10804828
25Type I diabetes mellitus_Homo sapiens_hsa049401.04897934
26Nicotine addiction_Homo sapiens_hsa050331.04201038
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03460309
28Homologous recombination_Homo sapiens_hsa034400.99279796
29Sulfur metabolism_Homo sapiens_hsa009200.96855930
30Olfactory transduction_Homo sapiens_hsa047400.96145109
31Proteasome_Homo sapiens_hsa030500.90196972
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88062285
33Fat digestion and absorption_Homo sapiens_hsa049750.84800671
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.81181209
35Tryptophan metabolism_Homo sapiens_hsa003800.75391254
36Fanconi anemia pathway_Homo sapiens_hsa034600.73892923
37Arachidonic acid metabolism_Homo sapiens_hsa005900.72968035
38One carbon pool by folate_Homo sapiens_hsa006700.71923128
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70161211
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68822397
41Tyrosine metabolism_Homo sapiens_hsa003500.66910789
42Basal cell carcinoma_Homo sapiens_hsa052170.66548821
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65866322
44Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65768711
45Metabolic pathways_Homo sapiens_hsa011000.65497175
46Retinol metabolism_Homo sapiens_hsa008300.63322587
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.61404965
48DNA replication_Homo sapiens_hsa030300.60359012
49Insulin secretion_Homo sapiens_hsa049110.58631493
50Morphine addiction_Homo sapiens_hsa050320.58456244
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.58010149
52Purine metabolism_Homo sapiens_hsa002300.57603353
53Rheumatoid arthritis_Homo sapiens_hsa053230.55576181
54Staphylococcus aureus infection_Homo sapiens_hsa051500.55160041
55Peroxisome_Homo sapiens_hsa041460.54139933
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53520052
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52271751
58Basal transcription factors_Homo sapiens_hsa030220.50495128
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50427068
60Systemic lupus erythematosus_Homo sapiens_hsa053220.49272858
61Nitrogen metabolism_Homo sapiens_hsa009100.47704933
62Butanoate metabolism_Homo sapiens_hsa006500.47444755
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47066905
64Collecting duct acid secretion_Homo sapiens_hsa049660.46789875
65Regulation of autophagy_Homo sapiens_hsa041400.45751940
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.44989087
67Hedgehog signaling pathway_Homo sapiens_hsa043400.44426730
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43830823
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42924741
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.42421267
71Chemical carcinogenesis_Homo sapiens_hsa052040.41632251
72Caffeine metabolism_Homo sapiens_hsa002320.40911343
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38366291
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37984006
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37778240
76GABAergic synapse_Homo sapiens_hsa047270.37638550
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37267265
78beta-Alanine metabolism_Homo sapiens_hsa004100.35559317
79Glycerolipid metabolism_Homo sapiens_hsa005610.35274356
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.34367544
81Nucleotide excision repair_Homo sapiens_hsa034200.33823337
82Ether lipid metabolism_Homo sapiens_hsa005650.33759432
83Carbohydrate digestion and absorption_Homo sapiens_hsa049730.33419757
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33338930
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31824872
86Serotonergic synapse_Homo sapiens_hsa047260.30546355
87Mismatch repair_Homo sapiens_hsa034300.30133326
88Hematopoietic cell lineage_Homo sapiens_hsa046400.29840903
89Fatty acid degradation_Homo sapiens_hsa000710.29617829
90Primary immunodeficiency_Homo sapiens_hsa053400.28393692
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25882266
92Taste transduction_Homo sapiens_hsa047420.25534450
93Viral myocarditis_Homo sapiens_hsa054160.23703245
94Axon guidance_Homo sapiens_hsa043600.22616037
95Cocaine addiction_Homo sapiens_hsa050300.22584098
96Phenylalanine metabolism_Homo sapiens_hsa003600.22237264
97Antigen processing and presentation_Homo sapiens_hsa046120.21949050
98Dopaminergic synapse_Homo sapiens_hsa047280.20937719
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20413006
100Base excision repair_Homo sapiens_hsa034100.20272508

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