RPL36AP45

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine ribonucleoside catabolic process (GO:0046133)9.92609440
2DNA deamination (GO:0045006)9.88219218
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450919.59508148
4Arp2/3 complex-mediated actin nucleation (GO:0034314)5.32929500
5negative regulation by host of viral transcription (GO:0043922)5.12726559
6eosinophil chemotaxis (GO:0048245)5.07024701
7negative regulation of T cell apoptotic process (GO:0070233)4.99439595
8pyrimidine nucleoside catabolic process (GO:0046135)4.91837911
9positive regulation of interleukin-8 secretion (GO:2000484)4.88314020
10sequestering of actin monomers (GO:0042989)4.83864326
11actin nucleation (GO:0045010)4.82494419
12positive T cell selection (GO:0043368)4.76464500
13eosinophil migration (GO:0072677)4.60062807
14regulation of regulatory T cell differentiation (GO:0045589)4.58812323
15regulation of activation of Janus kinase activity (GO:0010533)4.48304325
16positive thymic T cell selection (GO:0045059)4.48051053
17positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.37978980
18cytolysis (GO:0019835)4.35190019
19positive regulation of natural killer cell mediated immunity (GO:0002717)4.32881541
20negative regulation of viral genome replication (GO:0045071)4.28147015
21protein neddylation (GO:0045116)4.14136472
22positive regulation of B cell differentiation (GO:0045579)4.13601683
23macrophage chemotaxis (GO:0048246)4.03286832
24positive regulation of tolerance induction (GO:0002645)3.95632535
25mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95116857
26positive regulation of calcium-mediated signaling (GO:0050850)3.93242587
27regulation of T cell tolerance induction (GO:0002664)3.89442475
28T cell migration (GO:0072678)3.86846107
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.86251724
30positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.81834183
31cellular response to interleukin-15 (GO:0071350)3.81707022
32regulation of chronic inflammatory response (GO:0002676)3.81667210
33regulation of lymphocyte chemotaxis (GO:1901623)3.79418926
34mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.77148465
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.71331535
36regulation of natural killer cell mediated immunity (GO:0002715)3.71331535
37regulation of interleukin-8 secretion (GO:2000482)3.70178677
38negative T cell selection (GO:0043383)3.62028045
39negative regulation of lymphocyte apoptotic process (GO:0070229)3.58415238
40ATP synthesis coupled proton transport (GO:0015986)3.55075848
41energy coupled proton transport, down electrochemical gradient (GO:0015985)3.55075848
42respiratory electron transport chain (GO:0022904)3.46614622
43positive regulation of lymphocyte migration (GO:2000403)3.44674873
44regulation of cellular amino acid metabolic process (GO:0006521)3.44534373
45regulation of B cell receptor signaling pathway (GO:0050855)3.43825338
46positive regulation of cell killing (GO:0031343)3.42733413
47positive regulation of T cell chemotaxis (GO:0010820)3.42293568
48regulation of T cell chemotaxis (GO:0010819)3.42293568
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.42250873
50electron transport chain (GO:0022900)3.39226112
51positive regulation of monocyte chemotaxis (GO:0090026)3.35446119
52regulation of B cell differentiation (GO:0045577)3.35243685
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.35215191
54iron-sulfur cluster assembly (GO:0016226)3.32160841
55metallo-sulfur cluster assembly (GO:0031163)3.32160841
56thymic T cell selection (GO:0045061)3.29098835
57DNA demethylation (GO:0080111)3.28717537
58regulation of T cell receptor signaling pathway (GO:0050856)3.27738998
59antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27122426
60regulation of T cell apoptotic process (GO:0070232)3.25868104
61positive regulation of T cell apoptotic process (GO:0070234)3.25732695
62pyrimidine-containing compound catabolic process (GO:0072529)3.25330925
63positive regulation of T cell mediated cytotoxicity (GO:0001916)3.25112569
64T cell receptor signaling pathway (GO:0050852)3.21584854
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21437208
66positive regulation of gamma-delta T cell activation (GO:0046645)3.16005996
67T cell costimulation (GO:0031295)3.15908531
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13428494
69lymphocyte costimulation (GO:0031294)3.12191904
70proteasome assembly (GO:0043248)3.12150669
71regulation of tolerance induction (GO:0002643)3.09699172
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.09615051
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.09615051
74positive regulation of interleukin-1 beta secretion (GO:0050718)3.09598131
75signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06597932
76signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06597932
77signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06597932
78negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.06553386
79regulation of cell killing (GO:0031341)3.06269608
80regulation of viral genome replication (GO:0045069)3.06010601
81positive regulation of translational initiation (GO:0045948)3.03769867
82antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.03748028
83T cell selection (GO:0045058)3.03398760
84monocyte chemotaxis (GO:0002548)3.00065438
85positive regulation of defense response to virus by host (GO:0002230)2.96731701
86negative regulation of B cell proliferation (GO:0030889)2.96354170
87positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.96066735
88ribosomal small subunit assembly (GO:0000028)2.95041235
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.94519442
90positive regulation of interleukin-1 secretion (GO:0050716)2.92418390
91pyrimidine ribonucleoside metabolic process (GO:0046131)2.91465617
92response to interleukin-15 (GO:0070672)2.90467908
93regulation of chemokine-mediated signaling pathway (GO:0070099)2.90405795
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90053812
95negative regulation of ligase activity (GO:0051352)2.90053812
96signal transduction involved in DNA damage checkpoint (GO:0072422)2.89511367
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89511367
98cytidine deamination (GO:0009972)11.1676164
99cytidine metabolic process (GO:0046087)11.1676164
100cytidine catabolic process (GO:0006216)11.1676164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human8.07030028
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.04247705
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.81286683
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57875050
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.50002290
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.02071261
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.86795804
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.80463531
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75344231
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.60447281
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.44881978
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.42516283
13MYB_26560356_Chip-Seq_TH2_Human2.34725369
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.32519981
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.28067080
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26164002
17VDR_22108803_ChIP-Seq_LS180_Human2.15826031
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09643157
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.05084862
20VDR_23849224_ChIP-Seq_CD4+_Human2.05004147
21EZH2_22144423_ChIP-Seq_EOC_Human1.98804109
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85557534
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83971470
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81137729
25RUNX_20019798_ChIP-Seq_JUKART_Human1.79594146
26GATA3_27048872_Chip-Seq_THYMUS_Human1.78375614
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78230229
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77103200
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.71055016
30HTT_18923047_ChIP-ChIP_STHdh_Human1.70875923
31IGF1R_20145208_ChIP-Seq_DFB_Human1.64877950
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.58581974
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58294358
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.57325850
35GATA3_26560356_Chip-Seq_TH2_Human1.50012816
36MYB_26560356_Chip-Seq_TH1_Human1.47744670
37FOXP3_21729870_ChIP-Seq_TREG_Human1.46347769
38ZNF274_21170338_ChIP-Seq_K562_Hela1.43307229
39CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42596875
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.41070629
41SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35771773
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.34603640
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31642969
44PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28053336
45RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.23994244
46MAF_26560356_Chip-Seq_TH2_Human1.22455811
47TP53_22573176_ChIP-Seq_HFKS_Human1.21907710
48NANOG_20526341_ChIP-Seq_ESCs_Human1.20918651
49NCOR_22424771_ChIP-Seq_293T_Human1.20908578
50UTX_26944678_Chip-Seq_JUKART_Human1.20548084
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19173789
52STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.18945691
53TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18899985
54TAF2_19829295_ChIP-Seq_ESCs_Human1.17607678
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15792994
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14007728
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13622770
58AR_20517297_ChIP-Seq_VCAP_Human1.13399486
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11925143
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11683990
61CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11196916
62ELK1_19687146_ChIP-ChIP_HELA_Human1.11192658
63BCL6_27268052_Chip-Seq_Bcells_Human1.06416274
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06327531
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.04925158
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04925158
67GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.04794698
68TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02112113
69CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01546164
70CTCF_20526341_ChIP-Seq_ESCs_Human1.01202469
71MYC_19829295_ChIP-Seq_ESCs_Human1.01072466
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98737500
73GATA3_21878914_ChIP-Seq_MCF-7_Human0.98569524
74HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97168054
75GATA6_21074721_ChIP-Seq_CACO-2_Human0.96538818
76ERG_20517297_ChIP-Seq_VCAP_Human0.95403791
77NFE2_27457419_Chip-Seq_LIVER_Mouse0.95217955
78SOX2_19829295_ChIP-Seq_ESCs_Human0.94294640
79NANOG_19829295_ChIP-Seq_ESCs_Human0.94294640
80FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93552428
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93218512
82FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92325939
83YY1_22570637_ChIP-Seq_MALME-3M_Human0.92185815
84MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.91782707
85MAF_26560356_Chip-Seq_TH1_Human0.91768553
86POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91656987
87CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.91200694
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90484914
89GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.90086538
90RBPJ_21746931_ChIP-Seq_IB4_Human0.90063766
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.89423523
92MYC_18940864_ChIP-ChIP_HL60_Human0.89380305
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89063450
94AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87779833
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.87678997
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.87336475
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87249075
98CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86638043
99ERA_21632823_ChIP-Seq_H3396_Human0.85828370
100RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.85488031

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.37416897
2MP0009785_altered_susceptibility_to3.71050824
3MP0009333_abnormal_splenocyte_physiolog3.27293596
4MP0003763_abnormal_thymus_physiology3.15304089
5MP0001835_abnormal_antigen_presentation2.84152225
6MP0001873_stomach_inflammation2.73494884
7MP0006082_CNS_inflammation2.51475644
8MP0005000_abnormal_immune_tolerance2.50917345
9MP0002163_abnormal_gland_morphology2.30007717
10MP0002148_abnormal_hypersensitivity_rea2.27520856
11MP0005025_abnormal_response_to2.24465914
12MP0001800_abnormal_humoral_immune2.19822315
13MP0002420_abnormal_adaptive_immunity2.13982534
14MP0003866_abnormal_defecation2.12276791
15MP0002723_abnormal_immune_serum2.03527346
16MP0001819_abnormal_immune_cell2.03494918
17MP0002102_abnormal_ear_morphology2.00851094
18MP0001919_abnormal_reproductive_system1.97920734
19MP0002166_altered_tumor_susceptibility1.89839102
20MP0001790_abnormal_immune_system1.86868627
21MP0005387_immune_system_phenotype1.86868627
22MP0002933_joint_inflammation1.79245081
23MP0005645_abnormal_hypothalamus_physiol1.77610294
24MP0003646_muscle_fatigue1.69872224
25MP0000716_abnormal_immune_system1.64343329
26MP0002452_abnormal_antigen_presenting1.56409033
27MP0002405_respiratory_system_inflammati1.56247801
28MP0005379_endocrine/exocrine_gland_phen1.56221144
29MP0000703_abnormal_thymus_morphology1.55961089
30MP0002398_abnormal_bone_marrow1.55271176
31MP0010155_abnormal_intestine_physiology1.54614901
32MP0009379_abnormal_foot_pigmentation1.53116855
33MP0002006_tumorigenesis1.50938460
34MP0004145_abnormal_muscle_electrophysio1.49515943
35MP0005083_abnormal_biliary_tract1.48136888
36MP0005377_hearing/vestibular/ear_phenot1.47349362
37MP0003878_abnormal_ear_physiology1.47349362
38MP0004147_increased_porphyrin_level1.46944561
39MP0005389_reproductive_system_phenotype1.45821790
40MP0002722_abnormal_immune_system1.41681334
41MP0000685_abnormal_immune_system1.41257136
42MP0003011_delayed_dark_adaptation1.40148454
43MP0003448_altered_tumor_morphology1.40057362
44MP0003786_premature_aging1.36532723
45MP0001188_hyperpigmentation1.35786362
46MP0001845_abnormal_inflammatory_respons1.33911481
47MP0000689_abnormal_spleen_morphology1.33871645
48MP0001853_heart_inflammation1.33726874
49MP0002277_abnormal_respiratory_mucosa1.27031581
50MP0003880_abnormal_central_pattern1.22466518
51MP0003137_abnormal_impulse_conducting1.22197803
52MP0001905_abnormal_dopamine_level1.21759480
53MP0008872_abnormal_physiological_respon1.21443714
54MP0000372_irregular_coat_pigmentation1.19348882
55MP0002429_abnormal_blood_cell1.18884013
56MP0001485_abnormal_pinna_reflex1.13090004
57MP0006072_abnormal_retinal_apoptosis1.12584834
58MP0009763_increased_sensitivity_to1.10784631
59MP0005646_abnormal_pituitary_gland1.09316469
60MP0002736_abnormal_nociception_after1.09245039
61MP0005551_abnormal_eye_electrophysiolog1.09154637
62MP0002837_dystrophic_cardiac_calcinosis1.08439205
63MP0002876_abnormal_thyroid_physiology1.04385031
64MP0001968_abnormal_touch/_nociception1.04256128
65MP0003436_decreased_susceptibility_to1.02662921
66MP0002419_abnormal_innate_immunity1.02001000
67MP0002693_abnormal_pancreas_physiology0.97500243
68MP0008995_early_reproductive_senescence0.96291995
69MP0005075_abnormal_melanosome_morpholog0.95685018
70MP0008469_abnormal_protein_level0.93219700
71MP0006276_abnormal_autonomic_nervous0.92425214
72MP0009764_decreased_sensitivity_to0.92134999
73MP0002160_abnormal_reproductive_system0.92052956
74MP0005084_abnormal_gallbladder_morpholo0.89668953
75MP0001984_abnormal_olfaction0.89577352
76MP0005253_abnormal_eye_physiology0.88767872
77MP0002138_abnormal_hepatobiliary_system0.86392275
78MP0008877_abnormal_DNA_methylation0.84370357
79MP0003195_calcinosis0.83894371
80MP0003045_fibrosis0.83036941
81MP0010386_abnormal_urinary_bladder0.78987798
82MP0002638_abnormal_pupillary_reflex0.78314774
83MP0008875_abnormal_xenobiotic_pharmacok0.78236852
84MP0003567_abnormal_fetal_cardiomyocyte0.78045611
85MP0009765_abnormal_xenobiotic_induced0.77562612
86MP0006036_abnormal_mitochondrial_physio0.75955511
87MP0005310_abnormal_salivary_gland0.75769735
88MP0002095_abnormal_skin_pigmentation0.75091071
89MP0005636_abnormal_mineral_homeostasis0.75066572
90MP0001661_extended_life_span0.73361476
91MP0004885_abnormal_endolymph0.72844621
92MP0009745_abnormal_behavioral_response0.72449858
93MP0001348_abnormal_lacrimal_gland0.72275204
94MP0001542_abnormal_bone_strength0.71357029
95MP0008873_increased_physiological_sensi0.71040884
96MP0005464_abnormal_platelet_physiology0.70647636
97MP0002019_abnormal_tumor_incidence0.70293982
98MP0008789_abnormal_olfactory_epithelium0.69706775
99MP0005410_abnormal_fertilization0.68578481
100MP0001119_abnormal_female_reproductive0.68347331

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)6.45453087
2T lymphocytopenia (HP:0005403)5.40330615
3Abnormality of T cell number (HP:0011839)5.32237332
4Hypoproteinemia (HP:0003075)4.41769483
5Autoimmune hemolytic anemia (HP:0001890)4.39676577
6IgG deficiency (HP:0004315)4.31882934
7Increased IgM level (HP:0003496)4.16144999
8Acute necrotizing encephalopathy (HP:0006965)4.06823693
9Mitochondrial inheritance (HP:0001427)3.97399704
10Severe combined immunodeficiency (HP:0004430)3.91594574
113-Methylglutaconic aciduria (HP:0003535)3.81549504
12Abnormal mitochondria in muscle tissue (HP:0008316)3.80632155
13Elevated erythrocyte sedimentation rate (HP:0003565)3.74242932
14Abnormality of T cells (HP:0002843)3.59251198
15Increased intramyocellular lipid droplets (HP:0012240)3.56584196
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.48795608
17Progressive macrocephaly (HP:0004481)3.34326476
18Abnormality of eosinophils (HP:0001879)3.28080816
19Acute encephalopathy (HP:0006846)3.24616106
20Increased CSF lactate (HP:0002490)3.22953912
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.22553138
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.22553138
23Thyroiditis (HP:0100646)3.17636759
24Hepatocellular necrosis (HP:0001404)3.11876240
25Cerebral edema (HP:0002181)3.04893087
26Combined immunodeficiency (HP:0005387)3.03629097
27Abnormality of the prostate (HP:0008775)3.01697961
28Increased hepatocellular lipid droplets (HP:0006565)3.00820992
29Increased muscle lipid content (HP:0009058)2.94598414
30Chronic diarrhea (HP:0002028)2.79697642
31Abnormality of B cell number (HP:0010975)2.77158436
32Eosinophilia (HP:0001880)2.74936532
33Congenital stationary night blindness (HP:0007642)2.74264445
34Abnormal albumin level (HP:0012116)2.72556213
35Hypoalbuminemia (HP:0003073)2.72556213
36Encephalitis (HP:0002383)2.71626742
37Hepatic necrosis (HP:0002605)2.70978314
38Renal Fanconi syndrome (HP:0001994)2.67599709
39Lipid accumulation in hepatocytes (HP:0006561)2.64305367
40Abnormal rod and cone electroretinograms (HP:0008323)2.64070831
41Lymphopenia (HP:0001888)2.61159297
42Stomatitis (HP:0010280)2.55278225
43Pancreatic cysts (HP:0001737)2.54994564
44Abnormality of cells of the lymphoid lineage (HP:0012140)2.53304419
45Autoimmune thrombocytopenia (HP:0001973)2.52432601
46Abnormal delayed hypersensitivity skin test (HP:0002963)2.50712097
47Pancytopenia (HP:0001876)2.45272871
48Amyotrophic lateral sclerosis (HP:0007354)2.39341843
49Ureteral stenosis (HP:0000071)2.38878892
50Optic disc pallor (HP:0000543)2.36412341
51Leukocytosis (HP:0001974)2.34238647
52Hypoplasia of the thymus (HP:0000778)2.29878071
53Chronic obstructive pulmonary disease (HP:0006510)2.29525555
54Obstructive lung disease (HP:0006536)2.29525555
55Abnormality of macrophages (HP:0004311)2.28582849
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.25227696
57Attenuation of retinal blood vessels (HP:0007843)2.24858977
58Gangrene (HP:0100758)2.21124914
59Meningitis (HP:0001287)2.20462890
60B lymphocytopenia (HP:0010976)2.18005406
61Lactic acidosis (HP:0003128)2.16573174
62True hermaphroditism (HP:0010459)2.16365691
63Recurrent bronchitis (HP:0002837)2.16230627
64Joint swelling (HP:0001386)2.15301786
65Ureteral obstruction (HP:0006000)2.14346983
66Lethargy (HP:0001254)2.12054609
67Severe visual impairment (HP:0001141)2.09064762
68Hemiplegia (HP:0002301)2.08281000
69Increased serum lactate (HP:0002151)2.07908908
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.05108046
71Decreased central vision (HP:0007663)2.04333694
72Chronic mucocutaneous candidiasis (HP:0002728)2.04171265
73Recurrent cutaneous fungal infections (HP:0011370)2.04171265
74Pancreatic fibrosis (HP:0100732)2.02046960
75Renal cortical cysts (HP:0000803)2.01902618
76Granulocytopenia (HP:0001913)2.00973690
77Oral leukoplakia (HP:0002745)1.99564295
78Exercise intolerance (HP:0003546)1.99080910
79Molar tooth sign on MRI (HP:0002419)1.96382244
80Abnormality of midbrain morphology (HP:0002418)1.96382244
81Hypergammaglobulinemia (HP:0010702)1.96004744
82Recurrent otitis media (HP:0000403)1.93477752
83Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.93079582
84Exertional dyspnea (HP:0002875)1.91666175
85Pulmonary infiltrates (HP:0002113)1.90107877
86Respiratory failure (HP:0002878)1.89083937
87Lymphoma (HP:0002665)1.87151890
88Carpal bone hypoplasia (HP:0001498)1.86323940
89Gastrointestinal infarctions (HP:0005244)1.84753560
90Chest pain (HP:0100749)1.83278173
91Constricted visual fields (HP:0001133)1.82228089
92Methylmalonic aciduria (HP:0012120)1.82027656
93Abolished electroretinogram (ERG) (HP:0000550)1.81872526
94Abnormality of T cell physiology (HP:0011840)1.81152255
95Hemoptysis (HP:0002105)1.80955095
96IgM deficiency (HP:0002850)1.78129429
97Bronchitis (HP:0012387)1.77421740
98Radial bowing (HP:0002986)1.76378467
99Pancreatitis (HP:0001733)1.74398297
100Ketosis (HP:0001946)1.73972870

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK7.37343192
2KDR6.32670129
3TESK23.94252000
4BCKDK3.67572201
5ITK2.35836053
6TESK12.12620012
7MAP4K12.06929092
8LIMK11.98319028
9BUB11.89879760
10VRK21.85344795
11ADRBK21.80935636
12MAP3K121.68610363
13FES1.59913930
14GRK11.58044030
15ZAK1.56510599
16MAP4K21.48873275
17MST41.48226495
18PRKCQ1.35845066
19CSK1.35638099
20VRK11.32696108
21SYK1.24765473
22TAOK31.24084056
23GRK71.23532962
24MAP3K111.22272034
25STK161.21396866
26SCYL21.19529733
27TLK11.19321812
28LCK1.17390541
29WNK41.15535989
30TEC1.05816395
31PINK11.01823216
32MAP2K71.01146225
33NUAK10.97955433
34PIM20.97871720
35BTK0.96183180
36BCR0.94866556
37PIK3CA0.91396537
38MUSK0.89585166
39MYLK0.87749479
40TNK20.85871150
41MAP2K60.85861866
42GRK60.85220592
43PASK0.80002350
44TIE10.79251337
45CAMKK20.79238494
46LYN0.78455191
47IKBKB0.78279760
48ZAP700.74999047
49NME10.72227109
50TYRO30.71032372
51DAPK10.68689232
52FYN0.68302277
53MAPKAPK30.67546860
54RPS6KA50.65368004
55CSNK1G30.64248727
56OBSCN0.63923229
57INSRR0.63244871
58PIK3CG0.62987302
59FRK0.60697070
60AURKA0.58847995
61WNK30.58770894
62TRIM280.58553417
63CDK190.56501664
64BMPR1B0.56415404
65PIM10.55900613
66MAP3K50.55298847
67DAPK20.54869808
68CSF1R0.52976065
69ROCK10.51752185
70RPS6KA40.50742486
71CAMKK10.50548411
72SRPK10.50335261
73IKBKE0.49645091
74EIF2AK30.49547147
75IGF1R0.49530413
76MAPK130.47085618
77CSNK1G20.46386476
78PAK10.46279759
79PRKCA0.45612625
80JAK30.44823900
81CAMK2A0.43649975
82CSNK1A1L0.41314469
83ADRBK10.40517278
84PLK40.40288259
85PRKACA0.38757163
86INSR0.36057459
87DAPK30.35775496
88CSNK1G10.35534055
89DYRK20.35234480
90OXSR10.34801526
91CSNK2A10.34196150
92CLK10.30872862
93TBK10.30413786
94PLK20.28267838
95PDK20.27364767
96ATR0.26858806
97ARAF0.26410125
98CSNK1A10.25359854
99MATK0.24951091
100JAK20.22197865

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.24102143
2Proteasome_Homo sapiens_hsa030504.92543366
3Oxidative phosphorylation_Homo sapiens_hsa001903.87210875
4Parkinsons disease_Homo sapiens_hsa050123.22783118
5Graft-versus-host disease_Homo sapiens_hsa053323.00630738
6Autoimmune thyroid disease_Homo sapiens_hsa053202.85194392
7Antigen processing and presentation_Homo sapiens_hsa046122.75402544
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.59738420
9Allograft rejection_Homo sapiens_hsa053302.57414868
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.41989283
11Hematopoietic cell lineage_Homo sapiens_hsa046402.37828319
12Ribosome_Homo sapiens_hsa030102.23723827
13T cell receptor signaling pathway_Homo sapiens_hsa046602.20365317
14Alzheimers disease_Homo sapiens_hsa050102.19402707
15Type I diabetes mellitus_Homo sapiens_hsa049402.10535640
16Protein export_Homo sapiens_hsa030602.03105052
17RNA polymerase_Homo sapiens_hsa030202.02605544
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.01105453
19Huntingtons disease_Homo sapiens_hsa050161.91492959
20Rheumatoid arthritis_Homo sapiens_hsa053231.90551124
21Cardiac muscle contraction_Homo sapiens_hsa042601.71946131
22Phototransduction_Homo sapiens_hsa047441.48575827
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34233937
24Salmonella infection_Homo sapiens_hsa051321.34156518
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30512934
26Measles_Homo sapiens_hsa051621.23790543
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19160126
28Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08289318
29Nitrogen metabolism_Homo sapiens_hsa009100.99857664
30Linoleic acid metabolism_Homo sapiens_hsa005910.96090811
31Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.95976629
32Shigellosis_Homo sapiens_hsa051310.95825359
33NF-kappa B signaling pathway_Homo sapiens_hsa040640.95655860
34Viral myocarditis_Homo sapiens_hsa054160.93932760
35Peroxisome_Homo sapiens_hsa041460.92626908
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91619496
37Pyrimidine metabolism_Homo sapiens_hsa002400.87291899
38Malaria_Homo sapiens_hsa051440.86468702
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85191530
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84748651
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.84096242
42Intestinal immune network for IgA production_Homo sapiens_hsa046720.83716563
43Collecting duct acid secretion_Homo sapiens_hsa049660.83151922
44Caffeine metabolism_Homo sapiens_hsa002320.82072078
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76911095
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76373778
47Propanoate metabolism_Homo sapiens_hsa006400.71584592
48NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71049907
49Homologous recombination_Homo sapiens_hsa034400.70827406
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69716354
51Retinol metabolism_Homo sapiens_hsa008300.63452741
52Butanoate metabolism_Homo sapiens_hsa006500.62206302
53Asthma_Homo sapiens_hsa053100.61901317
54RNA degradation_Homo sapiens_hsa030180.61489164
55Systemic lupus erythematosus_Homo sapiens_hsa053220.61372422
56Purine metabolism_Homo sapiens_hsa002300.59780510
57Olfactory transduction_Homo sapiens_hsa047400.58819962
58DNA replication_Homo sapiens_hsa030300.56969188
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54599647
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.52399713
61Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50409888
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.49556045
63Fanconi anemia pathway_Homo sapiens_hsa034600.48557233
64Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45935537
65Chemical carcinogenesis_Homo sapiens_hsa052040.42987503
66Nicotine addiction_Homo sapiens_hsa050330.42168229
67Fatty acid elongation_Homo sapiens_hsa000620.41706066
68Chemokine signaling pathway_Homo sapiens_hsa040620.41649313
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41098233
70One carbon pool by folate_Homo sapiens_hsa006700.40146001
71Nucleotide excision repair_Homo sapiens_hsa034200.40102656
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39780554
73Metabolic pathways_Homo sapiens_hsa011000.39371796
74Spliceosome_Homo sapiens_hsa030400.38164579
75Mismatch repair_Homo sapiens_hsa034300.36001046
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.35423058
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.34806792
78Ether lipid metabolism_Homo sapiens_hsa005650.33887450
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.33460810
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32505222
81Prion diseases_Homo sapiens_hsa050200.31215657
82Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28963010
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28665687
84Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27740730
85Tryptophan metabolism_Homo sapiens_hsa003800.27728864
86Epstein-Barr virus infection_Homo sapiens_hsa051690.26962832
87Herpes simplex infection_Homo sapiens_hsa051680.22862956
88Morphine addiction_Homo sapiens_hsa050320.21128963
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20283030
90Taste transduction_Homo sapiens_hsa047420.19136297
91Legionellosis_Homo sapiens_hsa051340.17955683
92Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.17551212
93Staphylococcus aureus infection_Homo sapiens_hsa051500.16920380
94African trypanosomiasis_Homo sapiens_hsa051430.16545408
95Arachidonic acid metabolism_Homo sapiens_hsa005900.15812341
96Fat digestion and absorption_Homo sapiens_hsa049750.15755969
97GABAergic synapse_Homo sapiens_hsa047270.15674038
98Sulfur metabolism_Homo sapiens_hsa009200.15617427
99Steroid biosynthesis_Homo sapiens_hsa001000.15159908
100Alcoholism_Homo sapiens_hsa050340.14062089

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