ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.76856089
2	translational termination (GO:0006415)	9.25589889
3	maturation of SSU-rRNA (GO:0030490)	8.73841223
4	ribosomal small subunit assembly (GO:0000028)	8.68377549
5	translational elongation (GO:0006414)	7.88719131
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.70675973
7	cotranslational protein targeting to membrane (GO:0006613)	7.58517582
8	protein targeting to ER (GO:0045047)	7.51394353
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.18073500
10	cellular protein complex disassembly (GO:0043624)	7.04816472
11	protein localization to endoplasmic reticulum (GO:0070972)	7.04122406
12	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.86862421
13	viral life cycle (GO:0019058)	6.85023701
14	ATP synthesis coupled proton transport (GO:0015986)	6.62244643
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.62244643
16	translational initiation (GO:0006413)	6.06967508
17	protein complex disassembly (GO:0043241)	5.92623491
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.82233320
19	chaperone-mediated protein transport (GO:0072321)	5.56659496
20	macromolecular complex disassembly (GO:0032984)	5.52752260
21	protein targeting to membrane (GO:0006612)	5.20929387
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.07997473
23	respiratory electron transport chain (GO:0022904)	5.03035313
24	translation (GO:0006412)	4.95635754
25	electron transport chain (GO:0022900)	4.92255590
26	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.89675453
27	substrate-independent telencephalic tangential migration (GO:0021826)	4.89675453
28	ribosomal large subunit biogenesis (GO:0042273)	4.88094581
29	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.75899301
30	NADH dehydrogenase complex assembly (GO:0010257)	4.75899301
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.75899301
32	ncRNA 3-end processing (GO:0043628)	4.72861407
33	protein neddylation (GO:0045116)	4.66281141
34	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.65268079
35	ribonucleoprotein complex biogenesis (GO:0022613)	4.62522073
36	mRNA catabolic process (GO:0006402)	4.39547816
37	ATP biosynthetic process (GO:0006754)	4.18290293
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.13492070
39	cellular component biogenesis (GO:0044085)	4.13326258
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.02520246
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.02474606
42	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.02367442
43	GTP biosynthetic process (GO:0006183)	3.98297696
44	somite development (GO:0061053)	3.95474492
45	RNA catabolic process (GO:0006401)	3.89463254
46	protein complex biogenesis (GO:0070271)	3.83876168
47	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.73278166
48	oxygen transport (GO:0015671)	3.70547515
49	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60529212
50	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.58675910
51	UTP biosynthetic process (GO:0006228)	3.57004742
52	protein targeting (GO:0006605)	3.53731692
53	nonmotile primary cilium assembly (GO:0035058)	3.53661256
54	pyrimidine nucleotide catabolic process (GO:0006244)	3.52100965
55	establishment of protein localization to membrane (GO:0090150)	3.48705950
56	telencephalon development (GO:0021537)	3.47016604
57	protein targeting to mitochondrion (GO:0006626)	3.43572348
58	myoblast migration (GO:0051451)	3.38300210
59	chromatin remodeling at centromere (GO:0031055)	3.35947716
60	rRNA processing (GO:0006364)	3.35743256
61	kinetochore assembly (GO:0051382)	3.23838045
62	rRNA metabolic process (GO:0016072)	3.22038528
63	guanosine-containing compound biosynthetic process (GO:1901070)	3.19664079
64	UTP metabolic process (GO:0046051)	3.18746481
65	pseudouridine synthesis (GO:0001522)	3.18318233
66	oxidative phosphorylation (GO:0006119)	3.17579126
67	nucleoside triphosphate biosynthetic process (GO:0009142)	3.17375181
68	gas transport (GO:0015669)	3.12830533
69	hydrogen ion transmembrane transport (GO:1902600)	3.11938483
70	establishment of protein localization to organelle (GO:0072594)	3.11377910
71	establishment of protein localization to mitochondrion (GO:0072655)	3.03543339
72	CTP biosynthetic process (GO:0006241)	3.02768052
73	CTP metabolic process (GO:0046036)	3.02768052
74	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.99193637
75	protein localization to mitochondrion (GO:0070585)	2.93252358
76	behavioral response to nicotine (GO:0035095)	2.91751339
77	protein localization to membrane (GO:0072657)	2.89746307
78	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.88309828
79	homocysteine metabolic process (GO:0050667)	2.84313542
80	CENP-A containing nucleosome assembly (GO:0034080)	2.83296845
81	peptidyl-histidine modification (GO:0018202)	2.83229745
82	response to redox state (GO:0051775)	2.82076469
83	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81786549
84	cell proliferation in forebrain (GO:0021846)	2.80669422
85	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.79488151
86	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.78252566
87	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.77426418
88	regulation of cellular respiration (GO:0043457)	2.76200708
89	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.71163723
90	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.71163723
91	mitochondrial transport (GO:0006839)	2.70202645
92	segment specification (GO:0007379)	2.63955484
93	S-adenosylmethionine metabolic process (GO:0046500)	2.59618611
94	ribosome biogenesis (GO:0042254)	2.59182070
95	establishment of epithelial cell polarity (GO:0090162)	2.58689219
96	proton transport (GO:0015992)	2.54729075
97	peripheral nervous system neuron development (GO:0048935)	2.54296694
98	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.54207119
99	protein-cofactor linkage (GO:0018065)	2.54086094
100	ribosomal small subunit biogenesis (GO:0042274)	10.2663991

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.10119312
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.56912911
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.80082427
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72594199
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.16057416
6	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.07826573
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.97241789
8	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.91530713
9	XRN2_22483619_ChIP-Seq_HELA_Human	2.71573253
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.58705951
11	ZNF263_19887448_ChIP-Seq_K562_Human	2.54617284
12	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.50815349
13	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.44430783
14	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.35568073
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.35322736
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.25855929
17	TTF2_22483619_ChIP-Seq_HELA_Human	2.23827964
18	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.20672152
19	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.12735188
20	VDR_22108803_ChIP-Seq_LS180_Human	2.11441293
21	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.02557951
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93755403
23	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.93549224
24	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.91828826
25	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.78794880
26	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.72481732
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69273622
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.65906595
29	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65789012
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.64018090
31	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.63986613
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.62905786
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.62626118
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.57801569
35	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.56494591
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.52021176
37	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.51821535
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51425400
39	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.51246235
40	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49015680
41	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.48840853
42	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.46691967
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.43894934
44	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.42884788
45	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.41072213
46	IGF1R_20145208_ChIP-Seq_DFB_Human	1.40086044
47	FOXP3_21729870_ChIP-Seq_TREG_Human	1.38709478
48	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.38199162
49	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.35989334
50	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.32609445
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.30688252
52	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30079952
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.29834160
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.24414679
55	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.23314433
56	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.23314433
57	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.21291006
58	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.19241328
59	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18699089
60	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.18438057
61	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.17756239
62	SA1_27219007_Chip-Seq_Bcells_Human	1.16683580
63	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.15331670
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.14918702
65	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.12583107
66	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.11624687
67	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.11624687
68	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.11624687
69	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11207763
70	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.09997900
71	DCP1A_22483619_ChIP-Seq_HELA_Human	1.07542454
72	KDM5A_27292631_Chip-Seq_BREAST_Human	1.07226775
73	BCL6_27268052_Chip-Seq_Bcells_Human	1.06775463
74	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.06697170
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06249461
76	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.06217191
77	VDR_21846776_ChIP-Seq_THP-1_Human	1.03621243
78	ELK1_19687146_ChIP-ChIP_HELA_Human	1.03473121
79	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.02883277
80	CTCF_27219007_Chip-Seq_Bcells_Human	1.02783167
81	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.01293827
82	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96286202
83	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.95442474
84	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.95243754
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94547587
86	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93015334
87	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.92261868
88	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.91972152
89	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.91111188
90	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.90297123
91	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89506136
92	P68_20966046_ChIP-Seq_HELA_Human	0.88306391
93	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.88246086
94	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.87863444
95	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86718701
96	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.84395240
97	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.83819348
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.82097442
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.82008757
100	SA1_27219007_Chip-Seq_ERYTHROID_Human	0.81671093

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.90284941
2	MP0006292_abnormal_olfactory_placode	6.63891991
3	MP0003646_muscle_fatigue	3.59744109
4	MP0004145_abnormal_muscle_electrophysio	2.79986119
5	MP0000049_abnormal_middle_ear	2.53986772
6	MP0002163_abnormal_gland_morphology	2.45980658
7	MP0003122_maternal_imprinting	2.36117199
8	MP0003123_paternal_imprinting	2.21089995
9	MP0005377_hearing/vestibular/ear_phenot	2.05184490
10	MP0003878_abnormal_ear_physiology	2.05184490
11	MP0004147_increased_porphyrin_level	1.98162440
12	MP0000015_abnormal_ear_pigmentation	1.94599773
13	MP0004142_abnormal_muscle_tone	1.94197477
14	MP0002095_abnormal_skin_pigmentation	1.81469473
15	MP0002234_abnormal_pharynx_morphology	1.77984657
16	MP0003186_abnormal_redox_activity	1.72879127
17	MP0003136_yellow_coat_color	1.63792809
18	MP0000678_abnormal_parathyroid_gland	1.62053309
19	MP0001293_anophthalmia	1.60865595
20	MP0006036_abnormal_mitochondrial_physio	1.55362956
21	MP0003787_abnormal_imprinting	1.55179215
22	MP0002638_abnormal_pupillary_reflex	1.52357972
23	MP0010030_abnormal_orbit_morphology	1.49948974
24	MP0006276_abnormal_autonomic_nervous	1.49754091
25	MP0003693_abnormal_embryo_hatching	1.47537564
26	MP0008789_abnormal_olfactory_epithelium	1.44169719
27	MP0004858_abnormal_nervous_system	1.36072814
28	MP0003121_genomic_imprinting	1.35474567
29	MP0002160_abnormal_reproductive_system	1.33300823
30	MP0005083_abnormal_biliary_tract	1.32032416
31	MP0002837_dystrophic_cardiac_calcinosis	1.30343755
32	MP0002102_abnormal_ear_morphology	1.29240153
33	MP0001270_distended_abdomen	1.27993913
34	MP0003938_abnormal_ear_development	1.24901154
35	MP0008775_abnormal_heart_ventricle	1.23994087
36	MP0005670_abnormal_white_adipose	1.21094464
37	MP0002653_abnormal_ependyma_morphology	1.18767428
38	MP0005499_abnormal_olfactory_system	1.17842725
39	MP0005394_taste/olfaction_phenotype	1.17842725
40	MP0004885_abnormal_endolymph	1.17222107
41	MP0002177_abnormal_outer_ear	1.15963096
42	MP0000749_muscle_degeneration	1.15818112
43	MP0000750_abnormal_muscle_regeneration	1.13759010
44	MP0000631_abnormal_neuroendocrine_gland	1.13259596
45	MP0005646_abnormal_pituitary_gland	1.11556701
46	MP0008877_abnormal_DNA_methylation	1.09711052
47	MP0001188_hyperpigmentation	1.09158675
48	MP0002132_abnormal_respiratory_system	1.08220995
49	MP0001348_abnormal_lacrimal_gland	1.07497893
50	MP0000372_irregular_coat_pigmentation	1.07110049
51	MP0009046_muscle_twitch	1.03673612
52	MP0005379_endocrine/exocrine_gland_phen	1.02609589
53	MP0008058_abnormal_DNA_repair	0.98310912
54	MP0001968_abnormal_touch/_nociception	0.96748727
55	MP0002184_abnormal_innervation	0.95342502
56	MP0008932_abnormal_embryonic_tissue	0.94587414
57	MP0003567_abnormal_fetal_cardiomyocyte	0.93475306
58	MP0000955_abnormal_spinal_cord	0.91777402
59	MP0004233_abnormal_muscle_weight	0.90546805
60	MP0002752_abnormal_somatic_nervous	0.90481454
61	MP0004130_abnormal_muscle_cell	0.90137838
62	MP0003137_abnormal_impulse_conducting	0.90046993
63	MP0002116_abnormal_craniofacial_bone	0.88652799
64	MP0002932_abnormal_joint_morphology	0.87664779
65	MP0003937_abnormal_limbs/digits/tail_de	0.87315407
66	MP0000751_myopathy	0.86888298
67	MP0000778_abnormal_nervous_system	0.85211226
68	MP0002938_white_spotting	0.84924578
69	MP0005084_abnormal_gallbladder_morpholo	0.82159617
70	MP0003879_abnormal_hair_cell	0.82077686
71	MP0000026_abnormal_inner_ear	0.81247501
72	MP0008875_abnormal_xenobiotic_pharmacok	0.80848740
73	MP0005389_reproductive_system_phenotype	0.78723622
74	MP0002127_abnormal_cardiovascular_syste	0.78249931
75	MP0002233_abnormal_nose_morphology	0.77650464
76	MP0003755_abnormal_palate_morphology	0.77428082
77	MP0003880_abnormal_central_pattern	0.77011192
78	MP0002272_abnormal_nervous_system	0.76779999
79	MP0004133_heterotaxia	0.76104080
80	MP0009250_abnormal_appendicular_skeleto	0.75493728
81	MP0001324_abnormal_eye_pigmentation	0.72962486
82	MP0001984_abnormal_olfaction	0.71882016
83	MP0001286_abnormal_eye_development	0.71280155
84	MP0004742_abnormal_vestibular_system	0.70502643
85	MP0005636_abnormal_mineral_homeostasis	0.69104977
86	MP0002111_abnormal_tail_morphology	0.68447171
87	MP0005195_abnormal_posterior_eye	0.67872827
88	MP0002736_abnormal_nociception_after	0.67432393
89	MP0000759_abnormal_skeletal_muscle	0.67299330
90	MP0002697_abnormal_eye_size	0.65475364
91	MP0002557_abnormal_social/conspecific_i	0.65326894
92	MP0005257_abnormal_intraocular_pressure	0.65148525
93	MP0001905_abnormal_dopamine_level	0.63699099
94	MP0002210_abnormal_sex_determination	0.63172441
95	MP0001440_abnormal_grooming_behavior	0.62847317
96	MP0001299_abnormal_eye_distance/	0.62606124
97	MP0000733_abnormal_muscle_development	0.62064465
98	MP0005423_abnormal_somatic_nervous	0.61775418
99	MP0005174_abnormal_tail_pigmentation	0.61454431
100	MP0008872_abnormal_physiological_respon	0.61040596

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.77544368
2	Reticulocytopenia (HP:0001896)	5.68334437
3	Abnormality of cells of the erythroid lineage (HP:0012130)	5.43947230
4	Abnormal mitochondria in muscle tissue (HP:0008316)	5.34678169
5	Acute encephalopathy (HP:0006846)	4.83324111
6	Abnormal hemoglobin (HP:0011902)	4.76828589
7	Abnormal number of erythroid precursors (HP:0012131)	4.66021462
8	Macrocytic anemia (HP:0001972)	4.61686102
9	Mitochondrial inheritance (HP:0001427)	4.59790631
10	Progressive macrocephaly (HP:0004481)	4.57171686
11	Pallor (HP:0000980)	4.50643787
12	Increased CSF lactate (HP:0002490)	4.22945489
13	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.13201607
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.91511876
15	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.91511876
16	Cerebral edema (HP:0002181)	3.69439561
17	Increased intramyocellular lipid droplets (HP:0012240)	3.65002105
18	Hepatocellular necrosis (HP:0001404)	3.43019529
19	Abnormality of the heme biosynthetic pathway (HP:0010472)	3.31787109
20	Hepatic necrosis (HP:0002605)	3.28833524
21	Decreased circulating renin level (HP:0003351)	3.28513582
22	Molar tooth sign on MRI (HP:0002419)	3.27384291
23	Abnormality of midbrain morphology (HP:0002418)	3.27384291
24	Pancreatic fibrosis (HP:0100732)	3.16611213
25	Anencephaly (HP:0002323)	3.11197469
26	Increased hepatocellular lipid droplets (HP:0006565)	2.98130959
27	Increased muscle lipid content (HP:0009058)	2.91806080
28	Pancreatic cysts (HP:0001737)	2.88753787
29	Respiratory failure (HP:0002878)	2.77616554
30	Renal Fanconi syndrome (HP:0001994)	2.76136476
31	Microretrognathia (HP:0000308)	2.70089479
32	3-Methylglutaconic aciduria (HP:0003535)	2.67081031
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.63241149
34	Lactic acidosis (HP:0003128)	2.63202427
35	Exercise intolerance (HP:0003546)	2.62121534
36	True hermaphroditism (HP:0010459)	2.47719416
37	Increased serum lactate (HP:0002151)	2.45897918
38	Leukodystrophy (HP:0002415)	2.45055005
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41731586
40	Abnormality of alanine metabolism (HP:0010916)	2.41731586
41	Hyperalaninemia (HP:0003348)	2.41731586
42	Lipid accumulation in hepatocytes (HP:0006561)	2.38888963
43	Exertional dyspnea (HP:0002875)	2.37474016
44	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.36399113
45	Depressed nasal ridge (HP:0000457)	2.31757126
46	Abnormality of reticulocytes (HP:0004312)	2.29394764
47	Sclerocornea (HP:0000647)	2.22494272
48	Hyperthyroidism (HP:0000836)	2.21021076
49	Optic disc pallor (HP:0000543)	2.16136844
50	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.14046765
51	Absent thumb (HP:0009777)	2.13746433
52	Abnormal number of incisors (HP:0011064)	2.12087174
53	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.07558979
54	Respiratory difficulties (HP:0002880)	2.07138249
55	Cystic liver disease (HP:0006706)	2.06895674
56	Occipital encephalocele (HP:0002085)	2.06649688
57	Neoplasm of head and neck (HP:0012288)	2.03635762
58	Esophageal neoplasm (HP:0100751)	2.03635762
59	Abnormal rod and cone electroretinograms (HP:0008323)	2.03199274
60	Abnormal drinking behavior (HP:0030082)	2.01146623
61	Polydipsia (HP:0001959)	2.01146623
62	Partial duplication of thumb phalanx (HP:0009944)	1.99654405
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99508280
64	Rectal prolapse (HP:0002035)	1.94273426
65	Hyperphosphaturia (HP:0003109)	1.92825378
66	Lethargy (HP:0001254)	1.87737198
67	Pendular nystagmus (HP:0012043)	1.87275013
68	Abnormality of the anterior horn cell (HP:0006802)	1.83757139
69	Degeneration of anterior horn cells (HP:0002398)	1.83757139
70	Type 2 muscle fiber atrophy (HP:0003554)	1.83606687
71	Hypoplasia of the radius (HP:0002984)	1.82823904
72	Flat capital femoral epiphysis (HP:0003370)	1.82216374
73	Broad distal phalanx of finger (HP:0009836)	1.81955373
74	Truncus arteriosus (HP:0001660)	1.81821046
75	11 pairs of ribs (HP:0000878)	1.81392483
76	Down-sloping shoulders (HP:0200021)	1.81036675
77	Short middle phalanx of the 5th finger (HP:0004220)	1.80249154
78	Generalized aminoaciduria (HP:0002909)	1.78327281
79	Partial duplication of the phalanx of hand (HP:0009999)	1.77770667
80	Homocystinuria (HP:0002156)	1.76926082
81	Abnormality of homocysteine metabolism (HP:0010919)	1.76926082
82	Double outlet right ventricle (HP:0001719)	1.75515201
83	Congenital malformation of the right heart (HP:0011723)	1.75515201
84	Abnormality of urine glucose concentration (HP:0011016)	1.75034121
85	Glycosuria (HP:0003076)	1.75034121
86	Muscle fiber atrophy (HP:0100295)	1.74814079
87	Myokymia (HP:0002411)	1.74610013
88	Median cleft lip (HP:0000161)	1.74129165
89	X-linked dominant inheritance (HP:0001423)	1.72374656
90	Anomalous pulmonary venous return (HP:0010772)	1.72271611
91	Cleft eyelid (HP:0000625)	1.71183061
92	Abnormality of magnesium homeostasis (HP:0004921)	1.69584864
93	Porencephaly (HP:0002132)	1.69403541
94	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69208803
95	Absent/shortened dynein arms (HP:0200106)	1.69208803
96	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68671013
97	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.67520262
98	Abnormality of renal resorption (HP:0011038)	1.65934414
99	Hyperglycinemia (HP:0002154)	1.65752776
100	Increased serum pyruvate (HP:0003542)	1.64922751

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.35849430
2	PDK2	4.75620797
3	BCKDK	3.51072824
4	EPHB2	2.67583034
5	OBSCN	2.66964545
6	NEK1	2.55900639
7	LRRK2	2.32135752
8	PIK3CA	2.12683344
9	BLK	2.09501648
10	ADRBK2	2.08286182
11	TAOK1	2.05487240
12	ABL2	2.02409787
13	MARK2	1.85851673
14	PINK1	1.78033110
15	WNK4	1.60766622
16	CDC7	1.59641134
17	GRK1	1.42845953
18	DYRK2	1.38837418
19	AURKA	1.35840115
20	EIF2AK1	1.33834759
21	BUB1	1.28613871
22	DYRK3	1.26130117
23	MAP2K7	1.25321579
24	PHKG2	1.24524343
25	PHKG1	1.24524343
26	EPHA4	1.22159187
27	PLK4	1.22111068
28	LIMK1	1.17558376
29	ADRBK1	1.14057347
30	AURKB	1.10061691
31	STK11	1.07867257
32	NUAK1	1.02807013
33	TNIK	1.01969936
34	CCNB1	1.01167570
35	TIE1	0.99020707
36	CAMK1	0.97995223
37	STK4	0.96018334
38	MAPK12	0.94817541
39	MAP3K11	0.94612542
40	NME1	0.94472608
41	PIM2	0.94253463
42	CSNK2A2	0.93266597
43	GRK7	0.90910672
44	CAMKK2	0.90747456
45	PRKCG	0.88085042
46	RPS6KA6	0.86782227
47	NTRK2	0.84030812
48	CSNK2A1	0.82957557
49	DYRK1B	0.80522270
50	CDK19	0.80218357
51	TRIM28	0.80112835
52	PRKACA	0.80042941
53	RPS6KL1	0.78880034
54	RPS6KC1	0.78880034
55	ILK	0.76754625
56	PLK1	0.76582885
57	CHEK2	0.76427832
58	TTN	0.73764662
59	STK16	0.70849948
60	RPS6KA5	0.70742247
61	TLK1	0.70532916
62	DMPK	0.69311287
63	RPS6KB1	0.67729323
64	MARK1	0.65870561
65	PRKCI	0.63322668
66	BMPR1B	0.62864294
67	TRPM7	0.62331629
68	GRK5	0.60552510
69	MOS	0.60078289
70	MUSK	0.58443842
71	INSRR	0.58153524
72	BRAF	0.55672457
73	MKNK2	0.55187587
74	MELK	0.53036535
75	CSNK1E	0.52274688
76	WNK3	0.50311032
77	CAMK2A	0.49600787
78	CAMK1D	0.48758167
79	CAMK2D	0.48593329
80	CHEK1	0.47776494
81	PRKCQ	0.46884337
82	CASK	0.45610062
83	IKBKB	0.44892937
84	RPS6KA1	0.42918304
85	ARAF	0.42423555
86	RPS6KA2	0.42213199
87	CAMK4	0.41510667
88	PRKDC	0.41073276
89	CAMK2G	0.40212028
90	AKT1	0.37691824
91	CSNK1A1	0.35746439
92	DYRK1A	0.35402148
93	AKT2	0.34667661
94	PRKACG	0.34485636
95	PIM1	0.33520350
96	PRKCH	0.32412430
97	PRKACB	0.31246978
98	PIK3CG	0.31179637
99	DAPK3	0.30696549
100	CAMK1G	0.30587304

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	8.16273611
2	Oxidative phosphorylation_Homo sapiens_hsa00190	5.02545647
3	Parkinsons disease_Homo sapiens_hsa05012	4.45300094
4	Cardiac muscle contraction_Homo sapiens_hsa04260	3.47684402
5	Huntingtons disease_Homo sapiens_hsa05016	3.33906834
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.03905367
7	Alzheimers disease_Homo sapiens_hsa05010	3.03422684
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.96832893
9	One carbon pool by folate_Homo sapiens_hsa00670	2.64571021
10	RNA polymerase_Homo sapiens_hsa03020	1.95577524
11	DNA replication_Homo sapiens_hsa03030	1.70557242
12	Sulfur relay system_Homo sapiens_hsa04122	1.65500640
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.58172020
14	Homologous recombination_Homo sapiens_hsa03440	1.43614383
15	Folate biosynthesis_Homo sapiens_hsa00790	1.42110398
16	Pyrimidine metabolism_Homo sapiens_hsa00240	1.41754872
17	Spliceosome_Homo sapiens_hsa03040	1.39746152
18	Mismatch repair_Homo sapiens_hsa03430	1.37234248
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.35738245
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.28804891
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25120746
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.14943626
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.12867311
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.10057083
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.07214941
26	Proteasome_Homo sapiens_hsa03050	1.02887675
27	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.97175534
28	Purine metabolism_Homo sapiens_hsa00230	0.96092126
29	Base excision repair_Homo sapiens_hsa03410	0.95957938
30	RNA transport_Homo sapiens_hsa03013	0.95475363
31	RNA degradation_Homo sapiens_hsa03018	0.90835074
32	Linoleic acid metabolism_Homo sapiens_hsa00591	0.90689035
33	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.88278328
34	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87933767
35	Metabolic pathways_Homo sapiens_hsa01100	0.85304513
36	Protein export_Homo sapiens_hsa03060	0.84096902
37	Basal transcription factors_Homo sapiens_hsa03022	0.83403507
38	Nitrogen metabolism_Homo sapiens_hsa00910	0.75610217
39	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72613909
40	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.71179884
41	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.69484809
42	Basal cell carcinoma_Homo sapiens_hsa05217	0.69351487
43	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.69124923
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.66655738
45	Steroid biosynthesis_Homo sapiens_hsa00100	0.65540688
46	Nicotine addiction_Homo sapiens_hsa05033	0.65321120
47	Fatty acid elongation_Homo sapiens_hsa00062	0.62838429
48	Peroxisome_Homo sapiens_hsa04146	0.62236897
49	Sulfur metabolism_Homo sapiens_hsa00920	0.56762667
50	Arginine and proline metabolism_Homo sapiens_hsa00330	0.56322065
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54608740
52	Phenylalanine metabolism_Homo sapiens_hsa00360	0.52894556
53	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.50882557
54	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.50015266
55	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49828372
56	Fat digestion and absorption_Homo sapiens_hsa04975	0.49141506
57	Tyrosine metabolism_Homo sapiens_hsa00350	0.48309706
58	Tryptophan metabolism_Homo sapiens_hsa00380	0.48200440
59	Propanoate metabolism_Homo sapiens_hsa00640	0.48083057
60	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.47993206
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.47162321
62	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.45809643
63	Fatty acid degradation_Homo sapiens_hsa00071	0.45792166
64	Butanoate metabolism_Homo sapiens_hsa00650	0.43887921
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41988205
66	Morphine addiction_Homo sapiens_hsa05032	0.38983861
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38255895
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.35934362
69	Carbon metabolism_Homo sapiens_hsa01200	0.35247685
70	Olfactory transduction_Homo sapiens_hsa04740	0.33522373
71	Insulin secretion_Homo sapiens_hsa04911	0.30253229
72	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30189287
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29767955
74	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.29312753
75	Melanoma_Homo sapiens_hsa05218	0.25253922
76	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.25220518
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.23883268
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.22486636
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20608396
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20141214
81	Retinol metabolism_Homo sapiens_hsa00830	0.19140198
82	GABAergic synapse_Homo sapiens_hsa04727	0.18786529
83	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.18078093
84	Bile secretion_Homo sapiens_hsa04976	0.16291438
85	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.15923633
86	Fatty acid metabolism_Homo sapiens_hsa01212	0.15872889
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.15405268
88	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.15035045
89	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.14948742
90	Taste transduction_Homo sapiens_hsa04742	0.14814754
91	p53 signaling pathway_Homo sapiens_hsa04115	0.14426447
92	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.13951074
93	Selenocompound metabolism_Homo sapiens_hsa00450	0.13937014
94	Hippo signaling pathway_Homo sapiens_hsa04390	0.13533335
95	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.13160553
96	Phototransduction_Homo sapiens_hsa04744	0.13103086
97	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.12242585
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.10287166
99	Axon guidance_Homo sapiens_hsa04360	0.08995747
100	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.08892417

RPL36AP48

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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