RPL36AP51

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.59243096
2viral transcription (GO:0019083)9.34786646
3translational termination (GO:0006415)8.97672014
4ribosomal small subunit assembly (GO:0000028)8.14401491
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.36132154
6cotranslational protein targeting to membrane (GO:0006613)7.28153088
7translational elongation (GO:0006414)7.27127421
8protein targeting to ER (GO:0045047)7.18800828
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.86881448
10cellular protein complex disassembly (GO:0043624)6.79453027
11viral life cycle (GO:0019058)6.77432754
12protein localization to endoplasmic reticulum (GO:0070972)6.71751064
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.56468849
14maturation of SSU-rRNA (GO:0030490)6.26784625
15protein complex disassembly (GO:0043241)5.79289650
16ribosomal large subunit biogenesis (GO:0042273)5.77866822
17translational initiation (GO:0006413)5.59740985
18macromolecular complex disassembly (GO:0032984)5.42560383
19behavioral response to nicotine (GO:0035095)5.32130188
20ATP synthesis coupled proton transport (GO:0015986)5.06368519
21energy coupled proton transport, down electrochemical gradient (GO:0015985)5.06368519
22ribonucleoprotein complex biogenesis (GO:0022613)4.93567065
23protein targeting to membrane (GO:0006612)4.89121703
24cell proliferation in forebrain (GO:0021846)4.58111396
25nuclear-transcribed mRNA catabolic process (GO:0000956)4.42127659
26translation (GO:0006412)4.37597407
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.29806776
28cellular component biogenesis (GO:0044085)4.20803584
29mRNA catabolic process (GO:0006402)4.15865190
30epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.04404358
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.04283774
32regulation of cellular respiration (GO:0043457)4.02885799
33chaperone-mediated protein transport (GO:0072321)3.88402213
34protein neddylation (GO:0045116)3.79457591
35RNA catabolic process (GO:0006401)3.60069188
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.56215160
37NADH dehydrogenase complex assembly (GO:0010257)3.56215160
38mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56215160
39electron transport chain (GO:0022900)3.52819644
40respiratory electron transport chain (GO:0022904)3.51881489
41substrate-independent telencephalic tangential migration (GO:0021826)3.46716563
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.46716563
43pyrimidine nucleobase catabolic process (GO:0006208)3.45087228
44axonemal dynein complex assembly (GO:0070286)3.43811747
45negative regulation of mast cell activation (GO:0033004)3.35137817
46ATP biosynthetic process (GO:0006754)3.27368990
47ubiquinone biosynthetic process (GO:0006744)3.26155291
48establishment of protein localization to membrane (GO:0090150)3.23544192
49forebrain morphogenesis (GO:0048853)3.20919695
50protein complex biogenesis (GO:0070271)3.17745948
51protein targeting (GO:0006605)3.17435959
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.15472209
53negative regulation of cardiac muscle hypertrophy (GO:0010614)3.15196584
54negative regulation of glycogen biosynthetic process (GO:0045719)3.11320221
55ribosome biogenesis (GO:0042254)3.03816672
56mitochondrion transport along microtubule (GO:0047497)3.03298145
57establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03298145
58ubiquinone metabolic process (GO:0006743)3.02741559
59purine nucleoside triphosphate biosynthetic process (GO:0009145)3.02580854
60regulation of cilium movement (GO:0003352)2.98342272
61epithelial cilium movement (GO:0003351)2.95796588
62regulation of microtubule-based movement (GO:0060632)2.94127479
63establishment of mitochondrion localization (GO:0051654)2.93812500
64positive regulation of T cell apoptotic process (GO:0070234)2.92734218
65cardiovascular system development (GO:0072358)2.89914545
66termination of RNA polymerase III transcription (GO:0006386)2.89692228
67transcription elongation from RNA polymerase III promoter (GO:0006385)2.89692228
68response to redox state (GO:0051775)2.88782434
69peptidyl-histidine modification (GO:0018202)2.88633694
70establishment of protein localization to organelle (GO:0072594)2.88140372
71rRNA processing (GO:0006364)2.85840107
72mitochondrial respiratory chain complex assembly (GO:0033108)2.83888974
73negative regulation of muscle hypertrophy (GO:0014741)2.83779517
74regulation of activation of Janus kinase activity (GO:0010533)2.82858454
75protein polyglutamylation (GO:0018095)2.82704911
76synaptic transmission, cholinergic (GO:0007271)2.82549021
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80289889
78GTP biosynthetic process (GO:0006183)2.77799068
79rRNA metabolic process (GO:0016072)2.77115376
80DNA deamination (GO:0045006)2.76223378
81negative regulation of response to food (GO:0032096)2.76215972
82negative regulation of appetite (GO:0032099)2.76215972
83establishment of protein localization to mitochondrial membrane (GO:0090151)2.74580533
84nucleobase catabolic process (GO:0046113)2.73018383
85respiratory chain complex IV assembly (GO:0008535)2.71277727
86ncRNA 3-end processing (GO:0043628)2.68849633
87maturation of 5.8S rRNA (GO:0000460)2.66718644
88motile cilium assembly (GO:0044458)2.66540673
89regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.66121827
90pattern specification involved in kidney development (GO:0061004)2.62504105
91spinal cord association neuron differentiation (GO:0021527)2.61649208
92nonmotile primary cilium assembly (GO:0035058)2.61501351
93sequestering of actin monomers (GO:0042989)2.60801165
94cilium movement (GO:0003341)2.60214613
95protein localization to membrane (GO:0072657)2.59241381
96quinone biosynthetic process (GO:1901663)2.58693532
97membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.57730459
98transmission of nerve impulse (GO:0019226)2.50953244
99regulation of energy homeostasis (GO:2000505)2.50425616
100neuron fate determination (GO:0048664)2.48122224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.50032544
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.43572661
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.09505270
4NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.44078010
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.35628167
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.24179612
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.16679306
8ZNF274_21170338_ChIP-Seq_K562_Hela2.15915537
9EZH2_27294783_Chip-Seq_ESCs_Mouse2.15077297
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.11615573
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.10020817
12SRY_22984422_ChIP-ChIP_TESTIS_Rat2.03003596
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.00887298
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.94888282
15BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91460636
16JARID2_20075857_ChIP-Seq_MESCs_Mouse1.87113468
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86998074
18IRF1_19129219_ChIP-ChIP_H3396_Human1.83743722
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82683239
20REST_21632747_ChIP-Seq_MESCs_Mouse1.79958436
21VDR_22108803_ChIP-Seq_LS180_Human1.70703552
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.69185896
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.66548735
24MYC_18555785_ChIP-Seq_MESCs_Mouse1.65009905
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64941682
26XRN2_22483619_ChIP-Seq_HELA_Human1.62716968
27CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.61671580
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.60127011
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.55980152
30HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.55670218
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.53642316
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.53642316
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.53502728
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53347563
35RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53316886
36SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.53010974
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51677847
38KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.49523979
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.46153070
40TAF2_19829295_ChIP-Seq_ESCs_Human1.43750474
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43097687
42EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.40783644
43TTF2_22483619_ChIP-Seq_HELA_Human1.39593326
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.36796686
45TP53_22573176_ChIP-Seq_HFKS_Human1.33749205
46CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32824607
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32142663
48CTCF_27219007_Chip-Seq_Bcells_Human1.31556293
49NANOG_20526341_ChIP-Seq_ESCs_Human1.31259258
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27582970
51RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.27341743
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.26535324
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.25496051
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24808800
55P68_20966046_ChIP-Seq_HELA_Human1.24474808
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.21282900
57SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20224100
58TP53_20018659_ChIP-ChIP_R1E_Mouse1.19158930
59ELF1_20517297_ChIP-Seq_JURKAT_Human1.18690066
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16867279
61KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16842655
62BCL6_27268052_Chip-Seq_Bcells_Human1.16063331
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.15949274
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.15912018
65FOXP1_21924763_ChIP-Seq_HESCs_Human1.15785927
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15641778
67CTCF_20526341_ChIP-Seq_ESCs_Human1.14133982
68SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.13301602
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13078345
70CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12758475
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12103185
72SA1_27219007_Chip-Seq_Bcells_Human1.11598456
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11547281
74NCOR_22424771_ChIP-Seq_293T_Human1.11391529
75MYC_18940864_ChIP-ChIP_HL60_Human1.10543194
76RAC3_21632823_ChIP-Seq_H3396_Human1.10399985
77E2F1_20622854_ChIP-Seq_HELA_Human1.10383604
78EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.09144087
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08897345
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08834192
81ERA_21632823_ChIP-Seq_H3396_Human1.08581290
82YY1_22570637_ChIP-Seq_MALME-3M_Human1.08414626
83GABP_19822575_ChIP-Seq_HepG2_Human1.05886158
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05503001
85P300_27268052_Chip-Seq_Bcells_Human1.05090753
86THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04315336
87RNF2_27304074_Chip-Seq_NSC_Mouse1.04000981
88MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02151641
89TP63_19390658_ChIP-ChIP_HaCaT_Human1.01631631
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.01127204
91CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99948828
92MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98850300
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.98212920
94OCT4_19829295_ChIP-Seq_ESCs_Human0.98068624
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97262736
96TET1_21451524_ChIP-Seq_MESCs_Mouse0.97194414
97P53_21459846_ChIP-Seq_SAOS-2_Human0.95941372
98IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94981777
99MYC_19079543_ChIP-ChIP_MESCs_Mouse0.94809658
100TP53_22127205_ChIP-Seq_IMR90_Human0.94718661

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.50505870
2MP0006292_abnormal_olfactory_placode5.17383113
3MP0002653_abnormal_ependyma_morphology4.30176237
4MP0002837_dystrophic_cardiac_calcinosis2.99214284
5MP0003787_abnormal_imprinting2.96043100
6MP0003122_maternal_imprinting2.91593277
7MP0003123_paternal_imprinting2.85706056
8MP0008789_abnormal_olfactory_epithelium2.55498014
9MP0002163_abnormal_gland_morphology2.42197484
10MP0003646_muscle_fatigue2.37341035
11MP0005394_taste/olfaction_phenotype2.36211385
12MP0005499_abnormal_olfactory_system2.36211385
13MP0000049_abnormal_middle_ear2.13764473
14MP0002102_abnormal_ear_morphology2.01726089
15MP0001986_abnormal_taste_sensitivity2.00803214
16MP0004145_abnormal_muscle_electrophysio1.98643732
17MP0004142_abnormal_muscle_tone1.94269940
18MP0001348_abnormal_lacrimal_gland1.92968256
19MP0003121_genomic_imprinting1.92932888
20MP0005377_hearing/vestibular/ear_phenot1.85305851
21MP0003878_abnormal_ear_physiology1.85305851
22MP0008877_abnormal_DNA_methylation1.73873306
23MP0005379_endocrine/exocrine_gland_phen1.73452391
24MP0002160_abnormal_reproductive_system1.61415768
25MP0001968_abnormal_touch/_nociception1.58366115
26MP0001293_anophthalmia1.51026690
27MP0005646_abnormal_pituitary_gland1.46255986
28MP0002733_abnormal_thermal_nociception1.46117753
29MP0000678_abnormal_parathyroid_gland1.42768856
30MP0006276_abnormal_autonomic_nervous1.38533805
31MP0002272_abnormal_nervous_system1.37829898
32MP0005389_reproductive_system_phenotype1.35819107
33MP0009046_muscle_twitch1.34174446
34MP0002736_abnormal_nociception_after1.30887192
35MP0002638_abnormal_pupillary_reflex1.30337608
36MP0001485_abnormal_pinna_reflex1.29998553
37MP0001970_abnormal_pain_threshold1.26517892
38MP0004130_abnormal_muscle_cell1.26331397
39MP0009745_abnormal_behavioral_response1.25247451
40MP0000778_abnormal_nervous_system1.16439366
41MP0008872_abnormal_physiological_respon1.16412826
42MP0003880_abnormal_central_pattern1.14947303
43MP0001984_abnormal_olfaction1.14281744
44MP0001440_abnormal_grooming_behavior1.13048523
45MP0003186_abnormal_redox_activity1.12715216
46MP0001529_abnormal_vocalization1.11597317
47MP0005551_abnormal_eye_electrophysiolog1.11271251
48MP0002095_abnormal_skin_pigmentation1.11258011
49MP0003938_abnormal_ear_development1.09054738
50MP0005423_abnormal_somatic_nervous1.07940473
51MP0004133_heterotaxia1.06788092
52MP0001919_abnormal_reproductive_system1.04691703
53MP0004885_abnormal_endolymph1.03128626
54MP0006054_spinal_hemorrhage1.02903349
55MP0002735_abnormal_chemical_nociception1.01931554
56MP0002234_abnormal_pharynx_morphology1.01590626
57MP0003635_abnormal_synaptic_transmissio1.01168895
58MP0000569_abnormal_digit_pigmentation1.00239879
59MP0004742_abnormal_vestibular_system0.97737609
60MP0003879_abnormal_hair_cell0.96873949
61MP0003011_delayed_dark_adaptation0.96184382
62MP0010030_abnormal_orbit_morphology0.95775401
63MP0002938_white_spotting0.95769170
64MP0001905_abnormal_dopamine_level0.94283758
65MP0000631_abnormal_neuroendocrine_gland0.94035789
66MP0001502_abnormal_circadian_rhythm0.93948763
67MP0004084_abnormal_cardiac_muscle0.93311800
68MP0005174_abnormal_tail_pigmentation0.92813591
69MP0002557_abnormal_social/conspecific_i0.92567736
70MP0003942_abnormal_urinary_system0.90076471
71MP0000026_abnormal_inner_ear0.88363952
72MP0002063_abnormal_learning/memory/cond0.88345378
73MP0002734_abnormal_mechanical_nocicepti0.88123093
74MP0008775_abnormal_heart_ventricle0.88062077
75MP0005195_abnormal_posterior_eye0.87045505
76MP0002572_abnormal_emotion/affect_behav0.86426554
77MP0002277_abnormal_respiratory_mucosa0.86335819
78MP0002249_abnormal_larynx_morphology0.85197867
79MP0002876_abnormal_thyroid_physiology0.85186854
80MP0002822_catalepsy0.85025399
81MP0006072_abnormal_retinal_apoptosis0.82494516
82MP0001286_abnormal_eye_development0.82434539
83MP0002752_abnormal_somatic_nervous0.79951731
84MP0002064_seizures0.79236411
85MP0002184_abnormal_innervation0.78986222
86MP0000015_abnormal_ear_pigmentation0.77531105
87MP0001963_abnormal_hearing_physiology0.76981894
88MP0003936_abnormal_reproductive_system0.76579103
89MP0002233_abnormal_nose_morphology0.76156631
90MP0004859_abnormal_synaptic_plasticity0.74819208
91MP0000955_abnormal_spinal_cord0.74626488
92MP0003693_abnormal_embryo_hatching0.74597120
93MP0003937_abnormal_limbs/digits/tail_de0.73404497
94MP0001324_abnormal_eye_pigmentation0.68765545
95MP0009250_abnormal_appendicular_skeleto0.68051572
96MP0003755_abnormal_palate_morphology0.67652684
97MP0002697_abnormal_eye_size0.67164804
98MP0003136_yellow_coat_color0.66474436
99MP0003567_abnormal_fetal_cardiomyocyte0.65460147
100MP0002116_abnormal_craniofacial_bone0.65371529

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.43603589
2Abnormality of cells of the erythroid lineage (HP:0012130)5.26340219
3Chronic hepatic failure (HP:0100626)5.21928400
4Acute necrotizing encephalopathy (HP:0006965)4.35004329
5Abnormal number of erythroid precursors (HP:0012131)4.33143425
6Abnormal mitochondria in muscle tissue (HP:0008316)3.82919923
7Dynein arm defect of respiratory motile cilia (HP:0012255)3.80024764
8Absent/shortened dynein arms (HP:0200106)3.80024764
9Macrocytic anemia (HP:0001972)3.78412160
10Mitochondrial inheritance (HP:0001427)3.49260727
11Acute encephalopathy (HP:0006846)3.48620111
12Progressive macrocephaly (HP:0004481)3.44978750
13Septo-optic dysplasia (HP:0100842)3.28101433
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.21911991
15Abnormal ciliary motility (HP:0012262)3.19635125
16Pancreatic cysts (HP:0001737)3.16129701
17Pallor (HP:0000980)3.15596721
18Abnormality of midbrain morphology (HP:0002418)3.14345859
19Molar tooth sign on MRI (HP:0002419)3.14345859
20Abnormal respiratory motile cilium physiology (HP:0012261)3.09993775
21Increased CSF lactate (HP:0002490)3.07688218
22Pancreatic fibrosis (HP:0100732)3.03386029
23Abnormal respiratory motile cilium morphology (HP:0005938)2.78486746
24Abnormal respiratory epithelium morphology (HP:0012253)2.78486746
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74463964
26Renal Fanconi syndrome (HP:0001994)2.74252889
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.63415372
28Anophthalmia (HP:0000528)2.62188852
29Increased hepatocellular lipid droplets (HP:0006565)2.61493549
30Abnormal rod and cone electroretinograms (HP:0008323)2.55197181
31Tubular atrophy (HP:0000092)2.55172258
32Pendular nystagmus (HP:0012043)2.54379328
33Rib fusion (HP:0000902)2.53242501
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.52169823
35Cystic liver disease (HP:0006706)2.51794934
36Cerebral edema (HP:0002181)2.49941258
37Stenosis of the external auditory canal (HP:0000402)2.49597187
38Asplenia (HP:0001746)2.47973121
39Myokymia (HP:0002411)2.42098592
40Nephronophthisis (HP:0000090)2.41980723
41Congenital stationary night blindness (HP:0007642)2.40801426
42Optic disc pallor (HP:0000543)2.35395405
43Type II lissencephaly (HP:0007260)2.34397525
44True hermaphroditism (HP:0010459)2.33990139
45Renovascular hypertension (HP:0100817)2.33611587
46Abnormality of the diencephalon (HP:0010662)2.33294740
47Polydipsia (HP:0001959)2.32979116
48Abnormal drinking behavior (HP:0030082)2.32979116
49Hyperthyroidism (HP:0000836)2.32910514
50Lipid accumulation in hepatocytes (HP:0006561)2.32900935
513-Methylglutaconic aciduria (HP:0003535)2.31794350
52Abnormal number of incisors (HP:0011064)2.29635981
53Adrenal hypoplasia (HP:0000835)2.26726742
54Hepatocellular necrosis (HP:0001404)2.26510876
55Elfin facies (HP:0004428)2.25768651
56Absent thumb (HP:0009777)2.14623324
57Sclerocornea (HP:0000647)2.12865414
58Rhinitis (HP:0012384)2.07153258
59Depressed nasal ridge (HP:0000457)2.05616093
60Hepatic necrosis (HP:0002605)2.04868430
61Renal duplication (HP:0000075)2.04754948
62Abnormality of the renal medulla (HP:0100957)2.03019444
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01489225
64Absent septum pellucidum (HP:0001331)1.98763084
65Increased serum lactate (HP:0002151)1.98317880
66Anencephaly (HP:0002323)1.97461282
67Overriding aorta (HP:0002623)1.97007819
68Severe visual impairment (HP:0001141)1.96884390
69Elevated erythrocyte sedimentation rate (HP:0003565)1.94166771
70Oligodactyly (hands) (HP:0001180)1.93299993
71Limb dystonia (HP:0002451)1.92758183
72Abnormal hemoglobin (HP:0011902)1.92731646
73Medial flaring of the eyebrow (HP:0010747)1.89997631
74Testicular atrophy (HP:0000029)1.89412583
75Agitation (HP:0000713)1.88766121
76Stomatitis (HP:0010280)1.88753286
77Microretrognathia (HP:0000308)1.87897863
78Optic nerve hypoplasia (HP:0000609)1.87487599
79Growth hormone deficiency (HP:0000824)1.86120401
80Abnormality of the renal cortex (HP:0011035)1.85342818
81Leukodystrophy (HP:0002415)1.84423667
82Impulsivity (HP:0100710)1.84154417
83Tubulointerstitial nephritis (HP:0001970)1.83855328
84Maternal diabetes (HP:0009800)1.83534351
85Abnormality of renal resorption (HP:0011038)1.83491393
86Chronic bronchitis (HP:0004469)1.82939202
87Optic nerve coloboma (HP:0000588)1.80501974
88Increased intramyocellular lipid droplets (HP:0012240)1.79448077
89Bile duct proliferation (HP:0001408)1.79048997
90Abnormal biliary tract physiology (HP:0012439)1.79048997
91Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.78123899
92Hypogonadotrophic hypogonadism (HP:0000044)1.76262755
93Postaxial foot polydactyly (HP:0001830)1.74377997
94Progressive cerebellar ataxia (HP:0002073)1.74288255
95Type 2 muscle fiber atrophy (HP:0003554)1.74110798
96Oligodactyly (HP:0012165)1.69502025
97Polyuria (HP:0000103)1.68593368
98Abnormality of urine glucose concentration (HP:0011016)1.66171085
99Glycosuria (HP:0003076)1.66171085
100Occipital encephalocele (HP:0002085)1.65762723

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK5.53861591
2CAMKK14.31560132
3CAMKK23.71545501
4WNK42.76908936
5ADRBK22.72404050
6LIMK12.56888093
7TXK2.41134945
8LRRK22.39639264
9DYRK22.30614254
10BCKDK2.01804863
11BRSK11.94616173
12MAP3K131.81890535
13GRK11.71270633
14MAP3K111.67305977
15NME21.60220693
16NUAK11.51807720
17PINK11.51670679
18BRSK21.44163213
19TIE11.40873910
20CASK1.40642214
21EPHB21.36576417
22ZAK1.22293326
23CDC42BPA1.22073731
24CDK81.22025082
25MARK11.20386987
26CDK191.20072525
27NTRK21.20060309
28MAPK131.17639107
29SIK21.15370352
30PDK21.10473432
31PTK61.07864595
32MAP4K21.07844511
33PRKCQ1.07146093
34TLK11.07110499
35PRKCG1.04991661
36AURKA1.02412728
37MAP2K71.00934015
38CAMK11.00914141
39MAP4K10.99174991
40FRK0.98635924
41INSRR0.96121648
42TYRO30.94385189
43NEK20.91962712
44STK160.90868980
45BMPR1B0.90535034
46KDR0.89314791
47STK110.87858111
48MKNK20.86835797
49PIK3CA0.86169471
50ADRBK10.83458942
51RPS6KA50.80161884
52BTK0.79872114
53SRPK10.75199466
54EPHA40.73327127
55PAK30.73186372
56PHKG20.71505862
57PHKG10.71505862
58WNK10.70867494
59PIM20.67255177
60MINK10.64931875
61PRKCZ0.64253549
62WNK30.62772086
63PRKACA0.59094769
64MAP3K40.58000911
65CDC70.57971825
66CAMK1D0.57076451
67SGK2230.55850210
68SGK4940.55850210
69PRKCD0.55033120
70OBSCN0.54966113
71CSNK1G20.53126256
72PRKCH0.52893708
73CSNK2A20.52723646
74ABL20.52517330
75CAMK40.51681431
76SGK10.50925433
77RPS6KA60.50817455
78STK390.50462577
79CSNK1G30.49964818
80OXSR10.48838412
81CSNK1E0.46521253
82PLK40.46094255
83TEC0.43913717
84PRKCA0.41771875
85ITK0.41324895
86CAMK1G0.40884879
87MARK20.39852754
88SYK0.38899420
89LCK0.38894969
90RIPK40.38558339
91RPS6KA10.38125235
92MAPK120.37852989
93PLK10.36251392
94ATR0.34670873
95MUSK0.34548444
96PRKCI0.33776851
97CSNK1G10.33368729
98IKBKB0.32777259
99ROCK10.32365611
100RPS6KA30.32121614

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.93485368
2Oxidative phosphorylation_Homo sapiens_hsa001904.01050354
3Parkinsons disease_Homo sapiens_hsa050123.51424413
4Cardiac muscle contraction_Homo sapiens_hsa042602.69545336
5Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.59755040
6RNA polymerase_Homo sapiens_hsa030202.48218483
7Alzheimers disease_Homo sapiens_hsa050102.40250486
8Huntingtons disease_Homo sapiens_hsa050162.40074328
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.13077118
10Sulfur relay system_Homo sapiens_hsa041222.06607011
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00343528
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.97778040
13Linoleic acid metabolism_Homo sapiens_hsa005911.78634701
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70630256
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60184964
16Steroid biosynthesis_Homo sapiens_hsa001001.58972381
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56077053
18Protein export_Homo sapiens_hsa030601.42240946
19Butanoate metabolism_Homo sapiens_hsa006501.33773603
20Nicotine addiction_Homo sapiens_hsa050331.29183654
21Pyrimidine metabolism_Homo sapiens_hsa002401.26439639
22Nitrogen metabolism_Homo sapiens_hsa009101.23291634
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22456954
24RNA degradation_Homo sapiens_hsa030181.16039892
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13805538
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.12044777
27Vitamin B6 metabolism_Homo sapiens_hsa007501.11567945
28Homologous recombination_Homo sapiens_hsa034401.09996100
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07754819
30Peroxisome_Homo sapiens_hsa041461.07660322
31Phototransduction_Homo sapiens_hsa047441.07282371
32Arachidonic acid metabolism_Homo sapiens_hsa005901.03950522
33Tryptophan metabolism_Homo sapiens_hsa003800.96779727
34Fat digestion and absorption_Homo sapiens_hsa049750.94535152
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90433992
36Insulin secretion_Homo sapiens_hsa049110.89288808
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88824401
38Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87502885
39Olfactory transduction_Homo sapiens_hsa047400.83584625
40Sulfur metabolism_Homo sapiens_hsa009200.78552345
41Morphine addiction_Homo sapiens_hsa050320.76671698
42Glycerolipid metabolism_Homo sapiens_hsa005610.76107442
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74852880
44Steroid hormone biosynthesis_Homo sapiens_hsa001400.72099856
45Primary immunodeficiency_Homo sapiens_hsa053400.71713999
46Asthma_Homo sapiens_hsa053100.71511693
47Metabolic pathways_Homo sapiens_hsa011000.71408648
48Caffeine metabolism_Homo sapiens_hsa002320.69869251
49Purine metabolism_Homo sapiens_hsa002300.67599915
50Retinol metabolism_Homo sapiens_hsa008300.64778767
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64338745
52Taste transduction_Homo sapiens_hsa047420.64255852
53Proteasome_Homo sapiens_hsa030500.62292877
54Fanconi anemia pathway_Homo sapiens_hsa034600.60582460
55Basal cell carcinoma_Homo sapiens_hsa052170.60486233
56Ether lipid metabolism_Homo sapiens_hsa005650.59860592
57Cocaine addiction_Homo sapiens_hsa050300.59539182
58Chemical carcinogenesis_Homo sapiens_hsa052040.58536801
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.58446008
60Arginine and proline metabolism_Homo sapiens_hsa003300.56130876
61One carbon pool by folate_Homo sapiens_hsa006700.54657123
62Regulation of autophagy_Homo sapiens_hsa041400.54123332
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53204369
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52833547
65Serotonergic synapse_Homo sapiens_hsa047260.50569654
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50525984
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50218925
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49286788
69Basal transcription factors_Homo sapiens_hsa030220.48794173
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47867485
71Hedgehog signaling pathway_Homo sapiens_hsa043400.47596008
72Folate biosynthesis_Homo sapiens_hsa007900.47028922
73Ovarian steroidogenesis_Homo sapiens_hsa049130.46882586
74Tyrosine metabolism_Homo sapiens_hsa003500.45974664
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45386903
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44599082
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.44505395
78GABAergic synapse_Homo sapiens_hsa047270.42877212
79Axon guidance_Homo sapiens_hsa043600.42454384
80beta-Alanine metabolism_Homo sapiens_hsa004100.41864782
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41386373
82Propanoate metabolism_Homo sapiens_hsa006400.41118997
83Drug metabolism - other enzymes_Homo sapiens_hsa009830.41014791
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.40083253
85Collecting duct acid secretion_Homo sapiens_hsa049660.39865195
86Thyroid hormone synthesis_Homo sapiens_hsa049180.38410052
87Glutamatergic synapse_Homo sapiens_hsa047240.34628862
88Cholinergic synapse_Homo sapiens_hsa047250.31368593
89Dopaminergic synapse_Homo sapiens_hsa047280.31114245
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30189127
91Spliceosome_Homo sapiens_hsa030400.29761497
92Autoimmune thyroid disease_Homo sapiens_hsa053200.28751128
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26752472
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.25651075
95Galactose metabolism_Homo sapiens_hsa000520.24632721
96Rheumatoid arthritis_Homo sapiens_hsa053230.24483073
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.23940278
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23883564
99Graft-versus-host disease_Homo sapiens_hsa053320.23665245
100Allograft rejection_Homo sapiens_hsa053300.23473501

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