ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.19624357
2	viral transcription (GO:0019083)	8.12304386
3	translational termination (GO:0006415)	7.85668441
4	ribosomal small subunit assembly (GO:0000028)	7.19360457
5	maturation of SSU-rRNA (GO:0030490)	7.04935250
6	establishment of protein localization to mitochondrial membrane (GO:0090151)	6.75520584
7	ATP synthesis coupled proton transport (GO:0015986)	6.68743206
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.68743206
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.66153560
10	translational elongation (GO:0006414)	6.57356963
11	cotranslational protein targeting to membrane (GO:0006613)	6.52397977
12	protein targeting to ER (GO:0045047)	6.49839871
13	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.27372148
14	protein localization to endoplasmic reticulum (GO:0070972)	6.14322939
15	cellular protein complex disassembly (GO:0043624)	6.08886571
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.94980103
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.76433965
18	viral life cycle (GO:0019058)	5.73168903
19	chaperone-mediated protein transport (GO:0072321)	5.13693766
20	protein complex disassembly (GO:0043241)	5.13395094
21	translational initiation (GO:0006413)	5.07051009
22	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.93790233
23	macromolecular complex disassembly (GO:0032984)	4.83043453
24	ribosomal large subunit biogenesis (GO:0042273)	4.80896285
25	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.72772988
26	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.72772988
27	NADH dehydrogenase complex assembly (GO:0010257)	4.72772988
28	translation (GO:0006412)	4.43676491
29	respiratory electron transport chain (GO:0022904)	4.42512117
30	electron transport chain (GO:0022900)	4.39758870
31	protein targeting to membrane (GO:0006612)	4.39232666
32	protein complex biogenesis (GO:0070271)	4.29421733
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.08344419
34	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.99284498
35	ATP biosynthetic process (GO:0006754)	3.99168436
36	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.93438591
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.91879620
38	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.86970891
39	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.86970891
40	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.86071012
41	mRNA catabolic process (GO:0006402)	3.84433933
42	behavioral response to nicotine (GO:0035095)	3.81877664
43	GTP biosynthetic process (GO:0006183)	3.75294082
44	base-excision repair, AP site formation (GO:0006285)	3.75102280
45	ribonucleoprotein complex biogenesis (GO:0022613)	3.74106343
46	cellular component biogenesis (GO:0044085)	3.72187884
47	termination of RNA polymerase III transcription (GO:0006386)	3.60713438
48	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.60713438
49	peptidyl-histidine modification (GO:0018202)	3.56111572
50	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.55466841
51	pyrimidine nucleotide catabolic process (GO:0006244)	3.50601368
52	RNA catabolic process (GO:0006401)	3.49393895
53	inner mitochondrial membrane organization (GO:0007007)	3.49239337
54	centriole replication (GO:0007099)	3.49215180
55	response to pheromone (GO:0019236)	3.47039081
56	protein neddylation (GO:0045116)	3.45854824
57	respiratory chain complex IV assembly (GO:0008535)	3.39148576
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.35547644
59	UTP biosynthetic process (GO:0006228)	3.33807218
60	tongue development (GO:0043586)	3.28631846
61	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.26883509
62	establishment of protein localization to membrane (GO:0090150)	3.20093613
63	intracellular protein transmembrane import (GO:0044743)	3.18234101
64	respiratory tube development (GO:0030323)	3.17600114
65	deoxyribonucleotide catabolic process (GO:0009264)	3.16300192
66	kidney morphogenesis (GO:0060993)	3.12820279
67	UTP metabolic process (GO:0046051)	3.10598752
68	rRNA processing (GO:0006364)	3.09666928
69	metanephric nephron tubule development (GO:0072234)	3.09532490
70	metanephric tubule development (GO:0072170)	3.09532490
71	protein targeting to mitochondrion (GO:0006626)	3.07020085
72	rRNA metabolic process (GO:0016072)	3.04743531
73	hydrogen ion transmembrane transport (GO:1902600)	3.04041434
74	deoxyribose phosphate catabolic process (GO:0046386)	3.03372913
75	nucleoside triphosphate biosynthetic process (GO:0009142)	3.02018943
76	protein localization to mitochondrion (GO:0070585)	2.99317877
77	establishment of protein localization to mitochondrion (GO:0072655)	2.95686373
78	protein targeting (GO:0006605)	2.95470613
79	platelet dense granule organization (GO:0060155)	2.94415817
80	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.93333002
81	phenol-containing compound catabolic process (GO:0019336)	2.92072553
82	parturition (GO:0007567)	2.88640706
83	CTP biosynthetic process (GO:0006241)	2.88339865
84	CTP metabolic process (GO:0046036)	2.88339865
85	oxidative phosphorylation (GO:0006119)	2.86740803
86	lung-associated mesenchyme development (GO:0060484)	2.81010017
87	cell proliferation in forebrain (GO:0021846)	2.80301647
88	cardiovascular system development (GO:0072358)	2.78161256
89	pseudouridine synthesis (GO:0001522)	2.78018027
90	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.77741086
91	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	2.77360077
92	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.74195445
93	substrate-independent telencephalic tangential migration (GO:0021826)	2.74195445
94	establishment of protein localization to organelle (GO:0072594)	2.74072887
95	protein-cofactor linkage (GO:0018065)	2.73500006
96	cytochrome complex assembly (GO:0017004)	2.71810111
97	axon ensheathment in central nervous system (GO:0032291)	2.71247772
98	central nervous system myelination (GO:0022010)	2.71247772
99	proton transport (GO:0015992)	2.70158123
100	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.69805738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.89553817
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.13712239
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.91038948
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65725339
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.63252564
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.52173037
7	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.40175502
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.16646394
9	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.99245136
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.92356137
11	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.90454435
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.90238997
13	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.90026172
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.42656715
15	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.28846770
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.26340872
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.08713002
18	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.05397154
19	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.03861404
20	VDR_23849224_ChIP-Seq_CD4+_Human	2.01267805
21	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00266732
22	TTF2_22483619_ChIP-Seq_HELA_Human	1.96628182
23	VDR_22108803_ChIP-Seq_LS180_Human	1.96478644
24	IRF1_19129219_ChIP-ChIP_H3396_Human	1.89694474
25	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.88210810
26	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.77561132
27	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.75295992
28	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.74813522
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67061200
30	XRN2_22483619_ChIP-Seq_HELA_Human	1.63815706
31	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.63583837
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.62537329
33	GABP_19822575_ChIP-Seq_HepG2_Human	1.60650138
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.60183818
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57610756
36	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.55513298
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55305383
38	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.53259158
39	ZNF274_21170338_ChIP-Seq_K562_Hela	1.52544338
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.47820096
41	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.46689730
42	CIITA_25753668_ChIP-Seq_RAJI_Human	1.46033021
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.44835451
44	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.44812125
45	EWS_26573619_Chip-Seq_HEK293_Human	1.44701452
46	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.33953331
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.27990817
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.25833758
49	TAF15_26573619_Chip-Seq_HEK293_Human	1.24408076
50	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.23814949
51	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23440511
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.19023993
53	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.18690958
54	TAF2_19829295_ChIP-Seq_ESCs_Human	1.18300336
55	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.12936066
56	FUS_26573619_Chip-Seq_HEK293_Human	1.10475609
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.09712482
58	DCP1A_22483619_ChIP-Seq_HELA_Human	1.08092992
59	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.07653754
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07608218
61	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07608218
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07320989
63	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.07152095
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.06321529
65	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04906118
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.04727423
67	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.02864188
68	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02702518
69	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.00934087
70	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00409226
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00135913
72	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.97622152
73	MYC_19829295_ChIP-Seq_ESCs_Human	0.96730746
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96027347
75	SOX2_19829295_ChIP-Seq_ESCs_Human	0.95636981
76	NANOG_19829295_ChIP-Seq_ESCs_Human	0.95636981
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94397341
78	NCOR_22424771_ChIP-Seq_293T_Human	0.93568235
79	NANOG_20526341_ChIP-Seq_ESCs_Human	0.93563128
80	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.92671389
81	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.92134824
82	AR_20517297_ChIP-Seq_VCAP_Human	0.91607732
83	RNF2_27304074_Chip-Seq_NSC_Mouse	0.90291311
84	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.89955326
85	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.89939192
86	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88820208
87	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.88107042
88	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87264539
89	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.87042056
90	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.82871252
91	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.82681445
92	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.82592479
93	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.82193552
94	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.80422496
95	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.80183784
96	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.79789476
97	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.79334566
98	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.78994101
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.78932845
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.78521882

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.97456629
2	MP0006292_abnormal_olfactory_placode	5.10941470
3	MP0005646_abnormal_pituitary_gland	4.30159016
4	MP0002653_abnormal_ependyma_morphology	3.21052502
5	MP0010030_abnormal_orbit_morphology	2.86565171
6	MP0008789_abnormal_olfactory_epithelium	2.55604565
7	MP0003693_abnormal_embryo_hatching	2.29050163
8	MP0003122_maternal_imprinting	2.14463662
9	MP0000049_abnormal_middle_ear	2.12122390
10	MP0008875_abnormal_xenobiotic_pharmacok	2.05592002
11	MP0002163_abnormal_gland_morphology	2.03715415
12	MP0001346_abnormal_lacrimal_gland	2.01903959
13	MP0002837_dystrophic_cardiac_calcinosis	1.97672424
14	MP0005394_taste/olfaction_phenotype	1.95957959
15	MP0005499_abnormal_olfactory_system	1.95957959
16	MP0002234_abnormal_pharynx_morphology	1.95565619
17	MP0004147_increased_porphyrin_level	1.94479734
18	MP0003787_abnormal_imprinting	1.87042103
19	MP0002102_abnormal_ear_morphology	1.77632953
20	MP0005377_hearing/vestibular/ear_phenot	1.74733770
21	MP0003878_abnormal_ear_physiology	1.74733770
22	MP0005671_abnormal_response_to	1.72501981
23	MP0001485_abnormal_pinna_reflex	1.61976129
24	MP0001293_anophthalmia	1.57218670
25	MP0003880_abnormal_central_pattern	1.54848244
26	MP0004142_abnormal_muscle_tone	1.52199922
27	MP0002938_white_spotting	1.49806371
28	MP0003315_abnormal_perineum_morphology	1.43879126
29	MP0002095_abnormal_skin_pigmentation	1.40118589
30	MP0008877_abnormal_DNA_methylation	1.39332584
31	MP0002160_abnormal_reproductive_system	1.37135673
32	MP0003646_muscle_fatigue	1.36436662
33	MP0002638_abnormal_pupillary_reflex	1.27321736
34	MP0004885_abnormal_endolymph	1.22769323
35	MP0000372_irregular_coat_pigmentation	1.21857283
36	MP0002272_abnormal_nervous_system	1.21542910
37	MP0005379_endocrine/exocrine_gland_phen	1.21418263
38	MP0003806_abnormal_nucleotide_metabolis	1.19826476
39	MP0005389_reproductive_system_phenotype	1.13843547
40	MP0002736_abnormal_nociception_after	1.13157921
41	MP0004145_abnormal_muscle_electrophysio	1.12881677
42	MP0000026_abnormal_inner_ear	1.11903648
43	MP0000778_abnormal_nervous_system	1.10922698
44	MP0000678_abnormal_parathyroid_gland	1.09574381
45	MP0005174_abnormal_tail_pigmentation	1.08131986
46	MP0009053_abnormal_anal_canal	1.05751328
47	MP0008872_abnormal_physiological_respon	1.05483492
48	MP0001905_abnormal_dopamine_level	1.05483168
49	MP0005551_abnormal_eye_electrophysiolog	1.04365249
50	MP0005195_abnormal_posterior_eye	1.04279364
51	MP0004742_abnormal_vestibular_system	1.02947297
52	MP0003123_paternal_imprinting	1.01436950
53	MP0003121_genomic_imprinting	1.01270892
54	MP0005408_hypopigmentation	1.00882662
55	MP0003938_abnormal_ear_development	1.00511644
56	MP0001502_abnormal_circadian_rhythm	1.00308256
57	MP0006072_abnormal_retinal_apoptosis	0.99769777
58	MP0004133_heterotaxia	0.98596080
59	MP0005187_abnormal_penis_morphology	0.98544214
60	MP0001486_abnormal_startle_reflex	0.97259522
61	MP0002210_abnormal_sex_determination	0.96679981
62	MP0005248_abnormal_Harderian_gland	0.94187525
63	MP0001986_abnormal_taste_sensitivity	0.92737105
64	MP0001529_abnormal_vocalization	0.91044877
65	MP0003283_abnormal_digestive_organ	0.90880800
66	MP0001286_abnormal_eye_development	0.90077073
67	MP0001919_abnormal_reproductive_system	0.89824320
68	MP0000631_abnormal_neuroendocrine_gland	0.88874316
69	MP0001440_abnormal_grooming_behavior	0.88232654
70	MP0001835_abnormal_antigen_presentation	0.88159840
71	MP0009745_abnormal_behavioral_response	0.86887656
72	MP0000516_abnormal_urinary_system	0.86313306
73	MP0005367_renal/urinary_system_phenotyp	0.86313306
74	MP0009046_muscle_twitch	0.83697249
75	MP0002876_abnormal_thyroid_physiology	0.83471089
76	MP0001968_abnormal_touch/_nociception	0.83011475
77	MP0006036_abnormal_mitochondrial_physio	0.82034844
78	MP0003186_abnormal_redox_activity	0.81657017
79	MP0003937_abnormal_limbs/digits/tail_de	0.81144308
80	MP0002249_abnormal_larynx_morphology	0.78354575
81	MP0001119_abnormal_female_reproductive	0.73642073
82	MP0009333_abnormal_splenocyte_physiolog	0.73154696
83	MP0005332_abnormal_amino_acid	0.73032227
84	MP0008775_abnormal_heart_ventricle	0.70884852
85	MP0006276_abnormal_autonomic_nervous	0.70357087
86	MP0000613_abnormal_salivary_gland	0.69936546
87	MP0002177_abnormal_outer_ear	0.69856870
88	MP0001663_abnormal_digestive_system	0.69107066
89	MP0000015_abnormal_ear_pigmentation	0.68673391
90	MP0001963_abnormal_hearing_physiology	0.68414553
91	MP0002557_abnormal_social/conspecific_i	0.68091321
92	MP0000653_abnormal_sex_gland	0.67349023
93	MP0005075_abnormal_melanosome_morpholog	0.67136123
94	MP0002752_abnormal_somatic_nervous	0.66700142
95	MP0003936_abnormal_reproductive_system	0.66262921
96	MP0001800_abnormal_humoral_immune	0.65517777
97	MP0003718_maternal_effect	0.65362605
98	MP0008058_abnormal_DNA_repair	0.65130996
99	MP0001145_abnormal_male_reproductive	0.64788283
100	MP0001324_abnormal_eye_pigmentation	0.63039326

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.97685735
2	Acute necrotizing encephalopathy (HP:0006965)	4.80938450
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.55886003
4	Mitochondrial inheritance (HP:0001427)	4.46188244
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.40091187
6	Hepatocellular necrosis (HP:0001404)	4.20546983
7	Pancreatic fibrosis (HP:0100732)	4.16449517
8	Increased CSF lactate (HP:0002490)	4.12716754
9	Progressive macrocephaly (HP:0004481)	4.04567905
10	True hermaphroditism (HP:0010459)	3.99972930
11	Acute encephalopathy (HP:0006846)	3.86734929
12	Abnormal number of erythroid precursors (HP:0012131)	3.82848959
13	Pancreatic cysts (HP:0001737)	3.78076493
14	Increased hepatocellular lipid droplets (HP:0006565)	3.53494370
15	Macrocytic anemia (HP:0001972)	3.46531269
16	Hepatic necrosis (HP:0002605)	3.40027071
17	3-Methylglutaconic aciduria (HP:0003535)	3.25954644
18	Lipid accumulation in hepatocytes (HP:0006561)	3.21609443
19	Anencephaly (HP:0002323)	2.97251019
20	Sclerocornea (HP:0000647)	2.96370434
21	Increased intramyocellular lipid droplets (HP:0012240)	2.95516837
22	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.93961974
23	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.93961974
24	Cerebral edema (HP:0002181)	2.91607687
25	Abnormality of midbrain morphology (HP:0002418)	2.85847567
26	Molar tooth sign on MRI (HP:0002419)	2.85847567
27	Cystic liver disease (HP:0006706)	2.80743625
28	Pallor (HP:0000980)	2.78313428
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.77688070
30	Septo-optic dysplasia (HP:0100842)	2.76360090
31	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.76189539
32	Increased serum lactate (HP:0002151)	2.75926917
33	Renal Fanconi syndrome (HP:0001994)	2.71043589
34	Stenosis of the external auditory canal (HP:0000402)	2.70719056
35	Colon cancer (HP:0003003)	2.70631894
36	Exertional dyspnea (HP:0002875)	2.56977983
37	Microretrognathia (HP:0000308)	2.49714887
38	Absent thumb (HP:0009777)	2.47689880
39	Respiratory failure (HP:0002878)	2.42688147
40	Male pseudohermaphroditism (HP:0000037)	2.41372857
41	Postaxial foot polydactyly (HP:0001830)	2.41203277
42	Increased muscle lipid content (HP:0009058)	2.39550513
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.36847718
44	Asplenia (HP:0001746)	2.36252024
45	Hypoplasia of the radius (HP:0002984)	2.35915282
46	Maternal diabetes (HP:0009800)	2.35407066
47	Lactic acidosis (HP:0003128)	2.33426635
48	Pendular nystagmus (HP:0012043)	2.29699978
49	Leukodystrophy (HP:0002415)	2.29060908
50	Triphalangeal thumb (HP:0001199)	2.28151343
51	Optic disc pallor (HP:0000543)	2.26019933
52	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.25438142
53	Depressed nasal ridge (HP:0000457)	2.19153764
54	Oligodactyly (hands) (HP:0001180)	2.16307872
55	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.16130710
56	Forearm undergrowth (HP:0009821)	2.15726948
57	Cleft eyelid (HP:0000625)	2.12435097
58	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.10419884
59	Holoprosencephaly (HP:0001360)	2.10241790
60	Exercise intolerance (HP:0003546)	2.06143492
61	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05716898
62	Preaxial hand polydactyly (HP:0001177)	2.05504569
63	Occipital encephalocele (HP:0002085)	2.05477546
64	Nephronophthisis (HP:0000090)	2.01872242
65	Bile duct proliferation (HP:0001408)	2.00814283
66	Abnormal biliary tract physiology (HP:0012439)	2.00814283
67	Abnormality of renal resorption (HP:0011038)	1.98790141
68	Anophthalmia (HP:0000528)	1.98203844
69	Hypoplasia of the ulna (HP:0003022)	1.97988306
70	Chromsome breakage (HP:0040012)	1.97233502
71	Congenital hepatic fibrosis (HP:0002612)	1.97145189
72	Decreased central vision (HP:0007663)	1.95322272
73	Hypoplasia of the uterus (HP:0000013)	1.95170710
74	Meckel diverticulum (HP:0002245)	1.95086568
75	Aplasia/hypoplasia of the uterus (HP:0008684)	1.95027398
76	Abnormality of the renal medulla (HP:0100957)	1.94851812
77	Type II lissencephaly (HP:0007260)	1.94517259
78	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.92474307
79	Short thumb (HP:0009778)	1.91408138
80	Oligodactyly (HP:0012165)	1.91396052
81	Abnormality of magnesium homeostasis (HP:0004921)	1.91207778
82	Optic nerve coloboma (HP:0000588)	1.88358420
83	Abnormality of the ileum (HP:0001549)	1.86436768
84	Myokymia (HP:0002411)	1.84709781
85	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.84699976
86	Abnormality of cochlea (HP:0000375)	1.84271654
87	Congenital stationary night blindness (HP:0007642)	1.84149696
88	Ectopic kidney (HP:0000086)	1.84147300
89	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.83818908
90	Absent septum pellucidum (HP:0001331)	1.83700884
91	Supernumerary spleens (HP:0009799)	1.82297619
92	Abnormality of the renal cortex (HP:0011035)	1.81744698
93	Congenital, generalized hypertrichosis (HP:0004540)	1.79059644
94	Medial flaring of the eyebrow (HP:0010747)	1.78721724
95	Abnormality of the labia minora (HP:0012880)	1.77735577
96	Abnormality of the renal collecting system (HP:0004742)	1.77216234
97	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.77154303
98	Abnormal sex determination (HP:0012244)	1.75930007
99	Sex reversal (HP:0012245)	1.75930007
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.74886663

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	4.81203165
2	NUAK1	3.38796945
3	NME2	3.17707442
4	BMPR2	2.87422783
5	TLK1	2.83121427
6	NEK1	2.57644014
7	MAP3K12	2.52494508
8	DYRK2	2.45590639
9	PLK4	2.42724150
10	BUB1	2.34986487
11	MAP4K2	2.26155513
12	LRRK2	2.23992431
13	WNK4	2.17305321
14	TAOK3	2.07698686
15	BCKDK	1.97582807
16	TXK	1.96470002
17	MST4	1.91348304
18	MYLK	1.70807802
19	VRK2	1.61031152
20	STK16	1.52999975
21	EPHA4	1.42556802
22	CDC7	1.38430583
23	GRK1	1.35827558
24	AURKB	1.34149235
25	ADRBK2	1.31212129
26	TIE1	1.29957829
27	MARK3	1.25240996
28	CDK8	1.23601467
29	OXSR1	1.19435005
30	STK11	1.07993816
31	TRIM28	1.05804993
32	KDR	1.04811225
33	STK39	1.04049200
34	WNK3	1.03469427
35	ILK	1.01796531
36	ZAK	1.01762336
37	WNK1	1.00082626
38	BMPR1B	0.98489435
39	PASK	0.96958850
40	DAPK3	0.94812118
41	STK38L	0.94640910
42	FRK	0.94511839
43	CAMK1	0.91634456
44	CAMKK2	0.85766833
45	CSF1R	0.81233778
46	IKBKB	0.78403544
47	SRPK1	0.77684700
48	OBSCN	0.76770817
49	CAMK1D	0.76440121
50	SCYL2	0.75963897
51	INSRR	0.75800899
52	FLT3	0.74307819
53	ABL2	0.73319693
54	MUSK	0.72627216
55	TEC	0.69923053
56	PINK1	0.67483193
57	CSNK1G2	0.67357049
58	VRK1	0.66917420
59	ITK	0.65103663
60	DMPK	0.65051778
61	PTK6	0.64933809
62	CSNK2A2	0.64319980
63	CSNK2A1	0.62530013
64	RPS6KA6	0.61820839
65	PLK1	0.61378589
66	BTK	0.59416317
67	GRK5	0.56188382
68	PLK2	0.55325199
69	MAPK13	0.55071420
70	PRKCI	0.54055578
71	MAP4K1	0.52710158
72	PRKCG	0.51666610
73	NTRK2	0.50826398
74	TGFBR1	0.49838138
75	PRKACA	0.49806728
76	EPHB2	0.48414210
77	LYN	0.48242584
78	PRKCH	0.47040423
79	ADRBK1	0.46919041
80	RPS6KL1	0.46874983
81	RPS6KC1	0.46874983
82	NEK2	0.46722134
83	MAP3K9	0.46278280
84	CCNB1	0.45468681
85	CDK11A	0.44423945
86	ATR	0.43471564
87	IRAK1	0.43159688
88	PRKCA	0.43116316
89	PDK2	0.42156453
90	AURKA	0.41963083
91	KIT	0.41664611
92	STK3	0.40881304
93	CAMK1G	0.40782977
94	RPS6KA5	0.40608317
95	CDK14	0.39155016
96	ERBB3	0.37756365
97	PIK3CA	0.37300947
98	PLK3	0.36361379
99	STK24	0.35388189
100	PRKCE	0.32173321

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.01494860
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.16846396
3	Asthma_Homo sapiens_hsa05310	3.91398604
4	Parkinsons disease_Homo sapiens_hsa05012	3.57116457
5	One carbon pool by folate_Homo sapiens_hsa00670	2.78906331
6	Allograft rejection_Homo sapiens_hsa05330	2.78482861
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.71726414
8	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.70273566
9	RNA polymerase_Homo sapiens_hsa03020	2.64541970
10	Graft-versus-host disease_Homo sapiens_hsa05332	2.60366641
11	Huntingtons disease_Homo sapiens_hsa05016	2.46467474
12	Type I diabetes mellitus_Homo sapiens_hsa04940	2.41181714
13	Alzheimers disease_Homo sapiens_hsa05010	2.36530868
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.11264881
15	Cardiac muscle contraction_Homo sapiens_hsa04260	2.08085434
16	Proteasome_Homo sapiens_hsa03050	1.87988345
17	DNA replication_Homo sapiens_hsa03030	1.59020168
18	Homologous recombination_Homo sapiens_hsa03440	1.52249856
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.49735212
20	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.48512265
21	Protein export_Homo sapiens_hsa03060	1.47219261
22	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.46953510
23	Viral myocarditis_Homo sapiens_hsa05416	1.43342928
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.41525551
25	Base excision repair_Homo sapiens_hsa03410	1.40012642
26	RNA degradation_Homo sapiens_hsa03018	1.37089953
27	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.35444650
28	Sulfur relay system_Homo sapiens_hsa04122	1.32936973
29	Antigen processing and presentation_Homo sapiens_hsa04612	1.31668465
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.31441930
31	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30093606
32	Mismatch repair_Homo sapiens_hsa03430	1.28616403
33	Linoleic acid metabolism_Homo sapiens_hsa00591	1.21045074
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.19520000
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.15898579
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.10488745
37	Phototransduction_Homo sapiens_hsa04744	1.00094028
38	Nucleotide excision repair_Homo sapiens_hsa03420	0.94084152
39	Purine metabolism_Homo sapiens_hsa00230	0.87784363
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.85488380
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85308135
42	Spliceosome_Homo sapiens_hsa03040	0.83000143
43	Leishmaniasis_Homo sapiens_hsa05140	0.78768391
44	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74452225
45	Folate biosynthesis_Homo sapiens_hsa00790	0.72675242
46	RNA transport_Homo sapiens_hsa03013	0.67163002
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.62714709
48	Basal transcription factors_Homo sapiens_hsa03022	0.61721127
49	Non-homologous end-joining_Homo sapiens_hsa03450	0.61400431
50	Collecting duct acid secretion_Homo sapiens_hsa04966	0.61011445
51	Regulation of autophagy_Homo sapiens_hsa04140	0.59482367
52	Metabolic pathways_Homo sapiens_hsa01100	0.58180721
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.55559753
54	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.54984263
55	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.52711425
56	Fatty acid degradation_Homo sapiens_hsa00071	0.51075435
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.51073122
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.50033361
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.49104633
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48792511
61	Ether lipid metabolism_Homo sapiens_hsa00565	0.42829124
62	Caffeine metabolism_Homo sapiens_hsa00232	0.42706015
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.41843587
64	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.40867670
65	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40481508
66	Tryptophan metabolism_Homo sapiens_hsa00380	0.38168032
67	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.35839017
68	Peroxisome_Homo sapiens_hsa04146	0.32781233
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.32482172
70	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.31996015
71	Butanoate metabolism_Homo sapiens_hsa00650	0.31669912
72	Propanoate metabolism_Homo sapiens_hsa00640	0.31101887
73	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.29988710
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.29614019
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.29196319
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.28580364
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.28343220
78	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27788198
79	Retinol metabolism_Homo sapiens_hsa00830	0.27119076
80	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.25718811
81	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.24691793
82	Phagosome_Homo sapiens_hsa04145	0.23756265
83	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23704142
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.21614928
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21118847
86	Olfactory transduction_Homo sapiens_hsa04740	0.19337724
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.18475030
88	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.18215003
89	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.18015307
90	Herpes simplex infection_Homo sapiens_hsa05168	0.18015173
91	Nicotine addiction_Homo sapiens_hsa05033	0.15964265
92	Selenocompound metabolism_Homo sapiens_hsa00450	0.15906643
93	Fatty acid elongation_Homo sapiens_hsa00062	0.15794313
94	Toxoplasmosis_Homo sapiens_hsa05145	0.15226838
95	Sulfur metabolism_Homo sapiens_hsa00920	0.14931067
96	Fatty acid metabolism_Homo sapiens_hsa01212	0.14575953
97	Glutathione metabolism_Homo sapiens_hsa00480	0.13405216
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.13007918
99	Tuberculosis_Homo sapiens_hsa05152	0.11835402
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.11238859

RPL36AP53

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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