ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	signal peptide processing (GO:0006465)	7.83700777
2	valine metabolic process (GO:0006573)	7.11543612
3	viral transcription (GO:0019083)	6.82898968
4	translational termination (GO:0006415)	6.52640883
5	ribosomal small subunit biogenesis (GO:0042274)	6.35418086
6	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	6.27293992
7	mitochondrion transport along microtubule (GO:0047497)	6.27293992
8	establishment of mitochondrion localization (GO:0051654)	6.14626345
9	behavioral response to nicotine (GO:0035095)	6.10311026
10	prenylation (GO:0097354)	5.57601631
11	protein prenylation (GO:0018342)	5.57601631
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.42907098
13	protein targeting to ER (GO:0045047)	5.39651119
14	translational elongation (GO:0006414)	5.37136458
15	cotranslational protein targeting to membrane (GO:0006613)	5.34562113
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.24304933
17	viral life cycle (GO:0019058)	5.13116168
18	seminiferous tubule development (GO:0072520)	5.10416765
19	protein localization to endoplasmic reticulum (GO:0070972)	5.08253649
20	ribosomal large subunit biogenesis (GO:0042273)	4.94113543
21	ribosomal small subunit assembly (GO:0000028)	4.92490195
22	GTP biosynthetic process (GO:0006183)	4.87835445
23	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.81797834
24	cellular protein complex disassembly (GO:0043624)	4.81489384
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.71329259
26	macroautophagy (GO:0016236)	4.61584110
27	cytokinetic process (GO:0032506)	4.47101313
28	branched-chain amino acid catabolic process (GO:0009083)	4.37872532
29	maturation of SSU-rRNA (GO:0030490)	4.37345327
30	UTP biosynthetic process (GO:0006228)	4.30160200
31	ATP synthesis coupled proton transport (GO:0015986)	4.12064066
32	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.12064066
33	protein complex disassembly (GO:0043241)	4.09677632
34	UTP metabolic process (GO:0046051)	4.05686770
35	pyrimidine-containing compound transmembrane transport (GO:0072531)	4.01137050
36	translational initiation (GO:0006413)	4.00639225
37	amino acid salvage (GO:0043102)	3.96173288
38	L-methionine salvage (GO:0071267)	3.96173288
39	L-methionine biosynthetic process (GO:0071265)	3.96173288
40	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.91555087
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.84559510
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.84554952
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.84554952
44	Golgi to endosome transport (GO:0006895)	3.83770654
45	cardiovascular system development (GO:0072358)	3.82147828
46	macromolecular complex disassembly (GO:0032984)	3.76218849
47	radial glial cell differentiation (GO:0060019)	3.71080445
48	negative regulation of membrane potential (GO:0045837)	3.67070993
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.63546104
50	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.61311575
51	protein targeting to membrane (GO:0006612)	3.58533528
52	adaptation of signaling pathway (GO:0023058)	3.54487933
53	somite development (GO:0061053)	3.49791701
54	RNA destabilization (GO:0050779)	3.49154622
55	postsynaptic membrane organization (GO:0001941)	3.46238401
56	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.43671232
57	branched-chain amino acid metabolic process (GO:0009081)	3.41485658
58	nucleotide transmembrane transport (GO:1901679)	3.37958185
59	mRNA catabolic process (GO:0006402)	3.37178589
60	regulation of translation in response to stress (GO:0043555)	3.37090311
61	sulfur amino acid catabolic process (GO:0000098)	3.36011789
62	regulation of cGMP metabolic process (GO:0030823)	3.32133907
63	cardiolipin metabolic process (GO:0032048)	3.29275460
64	translation (GO:0006412)	3.27687547
65	water-soluble vitamin biosynthetic process (GO:0042364)	3.24159446
66	regulation of podosome assembly (GO:0071801)	3.19616273
67	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.18699474
68	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.16671787
69	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.12530369
70	CTP metabolic process (GO:0046036)	3.11279579
71	CTP biosynthetic process (GO:0006241)	3.11279579
72	phosphatidylglycerol biosynthetic process (GO:0006655)	3.10454145
73	RNA catabolic process (GO:0006401)	3.09310565
74	synaptic transmission, cholinergic (GO:0007271)	3.07294762
75	methionine biosynthetic process (GO:0009086)	3.07182088
76	N-terminal protein amino acid acetylation (GO:0006474)	3.00700032
77	ribonucleoprotein complex biogenesis (GO:0022613)	2.99975623
78	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.98168446
79	protein neddylation (GO:0045116)	2.97841017
80	DNA deamination (GO:0045006)	2.96393723
81	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.92979410
82	nucleoside diphosphate phosphorylation (GO:0006165)	2.91909750
83	protein complex biogenesis (GO:0070271)	2.91681466
84	L-fucose metabolic process (GO:0042354)	2.90651420
85	L-fucose catabolic process (GO:0042355)	2.90651420
86	fucose catabolic process (GO:0019317)	2.90651420
87	cellular modified amino acid catabolic process (GO:0042219)	2.87528988
88	regulation of regulatory T cell differentiation (GO:0045589)	2.87383955
89	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.87003113
90	substrate-independent telencephalic tangential migration (GO:0021826)	2.87003113
91	regulation of isotype switching to IgG isotypes (GO:0048302)	2.85899335
92	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	2.80978977
93	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.79433895
94	phosphatidylglycerol acyl-chain remodeling (GO:0036148)	2.78474180
95	viral protein processing (GO:0019082)	2.77354855
96	cellular component biogenesis (GO:0044085)	2.76318700
97	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.74889519
98	nonmotile primary cilium assembly (GO:0035058)	2.74620304
99	protein polyglutamylation (GO:0018095)	2.73332551
100	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.69333805

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.26144898
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.07901833
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	4.46613779
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.85322821
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.18409455
6	VDR_22108803_ChIP-Seq_LS180_Human	2.79931169
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.74552797
8	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.68535234
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.56401153
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.48185598
11	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.38110243
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.24673255
13	AR_21572438_ChIP-Seq_LNCaP_Human	2.19868773
14	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.92394122
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88732063
16	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.80858338
17	REST_21632747_ChIP-Seq_MESCs_Mouse	1.77964406
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.76841723
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.75594321
20	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.75201078
21	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69888341
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.68910751
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.68074842
24	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.65562530
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.64751442
26	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.62707318
27	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.61276685
28	GBX2_23144817_ChIP-Seq_PC3_Human	1.45283728
29	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45002346
30	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43890492
31	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.40724311
32	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.40706962
33	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.40387198
34	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.40173740
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.36454702
36	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.29929478
37	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.29693883
38	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.29580786
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29184477
40	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.28706405
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.26139546
42	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24855394
43	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.24565977
44	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.21736876
45	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.21057145
46	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.21035565
47	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.15074986
48	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.15046077
49	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.13441437
50	BCL6_27268052_Chip-Seq_Bcells_Human	1.13186308
51	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.13147048
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.12060581
53	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11480803
54	TTF2_22483619_ChIP-Seq_HELA_Human	1.10858429
55	ERA_21632823_ChIP-Seq_H3396_Human	1.10551091
56	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.09322394
57	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.07417638
58	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.07365102
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.07173448
60	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.06810450
61	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.06684379
62	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.06684379
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05906838
64	TP53_22573176_ChIP-Seq_HFKS_Human	1.03766607
65	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02456945
66	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.00960094
67	EWS_26573619_Chip-Seq_HEK293_Human	1.00740704
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.00664111
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.00664111
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98004252
71	NANOG_20526341_ChIP-Seq_ESCs_Human	0.96808474
72	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96009208
73	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.94979072
74	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.94869525
75	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.94591042
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.93681635
77	SOX2_21211035_ChIP-Seq_LN229_Human	0.93031749
78	CTCF_20526341_ChIP-Seq_ESCs_Human	0.92648872
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.92026730
80	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91940833
81	CBP_20019798_ChIP-Seq_JUKART_Human	0.91662804
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.91662804
83	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.91645987
84	ER_23166858_ChIP-Seq_MCF-7_Human	0.90684709
85	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.90456679
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89292104
87	NANOG_19829295_ChIP-Seq_ESCs_Human	0.88233832
88	SOX2_19829295_ChIP-Seq_ESCs_Human	0.88233832
89	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.87621863
90	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.87464530
91	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.87383193
92	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.86848833
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86217045
94	TP53_20018659_ChIP-ChIP_R1E_Mouse	0.86079353
95	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.85588925
96	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.85552088
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.85504908
98	XRN2_22483619_ChIP-Seq_HELA_Human	0.85302610
99	SA1_27219007_Chip-Seq_Bcells_Human	0.83932139
100	MYC_19829295_ChIP-Seq_ESCs_Human	0.82501114

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	9.65737144
2	MP0003646_muscle_fatigue	4.30274754
3	MP0006292_abnormal_olfactory_placode	3.22299021
4	MP0004858_abnormal_nervous_system	2.86978282
5	MP0003122_maternal_imprinting	2.82352171
6	MP0008877_abnormal_DNA_methylation	2.79709533
7	MP0003787_abnormal_imprinting	2.75308798
8	MP0002638_abnormal_pupillary_reflex	2.62946453
9	MP0005397_hematopoietic_system_phenotyp	2.26052317
10	MP0001545_abnormal_hematopoietic_system	2.26052317
11	MP0003121_genomic_imprinting	2.06420559
12	MP0002736_abnormal_nociception_after	2.04721703
13	MP0004145_abnormal_muscle_electrophysio	1.88231363
14	MP0008789_abnormal_olfactory_epithelium	1.85204549
15	MP0001968_abnormal_touch/_nociception	1.70740356
16	MP0005551_abnormal_eye_electrophysiolog	1.66584177
17	MP0002102_abnormal_ear_morphology	1.59730839
18	MP0000049_abnormal_middle_ear	1.59039866
19	MP0003878_abnormal_ear_physiology	1.56532961
20	MP0005377_hearing/vestibular/ear_phenot	1.56532961
21	MP0005645_abnormal_hypothalamus_physiol	1.56399754
22	MP0004885_abnormal_endolymph	1.55393357
23	MP0005499_abnormal_olfactory_system	1.54004504
24	MP0005394_taste/olfaction_phenotype	1.54004504
25	MP0002653_abnormal_ependyma_morphology	1.52951355
26	MP0006276_abnormal_autonomic_nervous	1.45470812
27	MP0005084_abnormal_gallbladder_morpholo	1.43344418
28	MP0006072_abnormal_retinal_apoptosis	1.38029315
29	MP0004142_abnormal_muscle_tone	1.36953010
30	MP0002095_abnormal_skin_pigmentation	1.35341935
31	MP0001853_heart_inflammation	1.29216044
32	MP0002557_abnormal_social/conspecific_i	1.28840216
33	MP0005195_abnormal_posterior_eye	1.28585572
34	MP0001529_abnormal_vocalization	1.22527210
35	MP0002837_dystrophic_cardiac_calcinosis	1.22023121
36	MP0003693_abnormal_embryo_hatching	1.21731412
37	MP0008058_abnormal_DNA_repair	1.21049213
38	MP0002272_abnormal_nervous_system	1.17967633
39	MP0008872_abnormal_physiological_respon	1.16281481
40	MP0004130_abnormal_muscle_cell	1.12769755
41	MP0000534_abnormal_ureter_morphology	1.12391705
42	MP0003136_yellow_coat_color	1.10339453
43	MP0002184_abnormal_innervation	1.07872006
44	MP0000778_abnormal_nervous_system	1.07377127
45	MP0002928_abnormal_bile_duct	1.01683326
46	MP0001286_abnormal_eye_development	1.01415962
47	MP0003718_maternal_effect	1.01413867
48	MP0004742_abnormal_vestibular_system	1.01218308
49	MP0001986_abnormal_taste_sensitivity	0.98079238
50	MP0002752_abnormal_somatic_nervous	0.96412933
51	MP0002229_neurodegeneration	0.94312030
52	MP0001486_abnormal_startle_reflex	0.94081678
53	MP0003635_abnormal_synaptic_transmissio	0.89940885
54	MP0001293_anophthalmia	0.89757764
55	MP0002138_abnormal_hepatobiliary_system	0.89498648
56	MP0000955_abnormal_spinal_cord	0.89335370
57	MP0003011_delayed_dark_adaptation	0.89090804
58	MP0009046_muscle_twitch	0.87924249
59	MP0001663_abnormal_digestive_system	0.85753322
60	MP0005389_reproductive_system_phenotype	0.85604039
61	MP0000604_amyloidosis	0.84206168
62	MP0002572_abnormal_emotion/affect_behav	0.82896858
63	MP0000026_abnormal_inner_ear	0.81975926
64	MP0000613_abnormal_salivary_gland	0.81745626
65	MP0005360_urolithiasis	0.81496369
66	MP0004133_heterotaxia	0.81241684
67	MP0002160_abnormal_reproductive_system	0.80510588
68	MP0001440_abnormal_grooming_behavior	0.80165943
69	MP0003879_abnormal_hair_cell	0.80107424
70	MP0001188_hyperpigmentation	0.79607109
71	MP0001970_abnormal_pain_threshold	0.79146011
72	MP0001485_abnormal_pinna_reflex	0.78687801
73	MP0008875_abnormal_xenobiotic_pharmacok	0.78571448
74	MP0002063_abnormal_learning/memory/cond	0.75843683
75	MP0002822_catalepsy	0.75413938
76	MP0002882_abnormal_neuron_morphology	0.73301348
77	MP0002733_abnormal_thermal_nociception	0.72507460
78	MP0004147_increased_porphyrin_level	0.71856164
79	MP0003938_abnormal_ear_development	0.71678766
80	MP0005670_abnormal_white_adipose	0.71512687
81	MP0005423_abnormal_somatic_nervous	0.71171418
82	MP0002067_abnormal_sensory_capabilities	0.70831116
83	MP0003942_abnormal_urinary_system	0.70621619
84	MP0003385_abnormal_body_wall	0.69621623
85	MP0002938_white_spotting	0.69224869
86	MP0009250_abnormal_appendicular_skeleto	0.68972102
87	MP0001919_abnormal_reproductive_system	0.68411337
88	MP0009745_abnormal_behavioral_response	0.68307601
89	MP0002735_abnormal_chemical_nociception	0.67909487
90	MP0002734_abnormal_mechanical_nocicepti	0.66557807
91	MP0001963_abnormal_hearing_physiology	0.65062027
92	MP0003329_amyloid_beta_deposits	0.63516713
93	MP0005381_digestive/alimentary_phenotyp	0.63307871
94	MP0005386_behavior/neurological_phenoty	0.63137570
95	MP0004924_abnormal_behavior	0.63137570
96	MP0003283_abnormal_digestive_organ	0.62276640
97	MP0001905_abnormal_dopamine_level	0.59735781
98	MP0008569_lethality_at_weaning	0.58370485
99	MP0000631_abnormal_neuroendocrine_gland	0.57673554
100	MP0004264_abnormal_extraembryonic_tissu	0.56812288

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	8.29714870
2	Pendular nystagmus (HP:0012043)	7.24520676
3	Abnormal rod and cone electroretinograms (HP:0008323)	5.77149456
4	Decreased central vision (HP:0007663)	5.30044515
5	Acanthocytosis (HP:0001927)	4.91446518
6	Disinhibition (HP:0000734)	4.83552964
7	Increased corneal curvature (HP:0100692)	4.36849110
8	Keratoconus (HP:0000563)	4.36849110
9	Personality changes (HP:0000751)	4.16859426
10	Self-mutilation (HP:0000742)	4.16579176
11	Attenuation of retinal blood vessels (HP:0007843)	3.72018738
12	Reticulocytopenia (HP:0001896)	3.63227453
13	Pallor (HP:0000980)	3.55862852
14	Cerebral hypomyelination (HP:0006808)	3.39458537
15	Dyskinesia (HP:0100660)	3.19258314
16	Inappropriate behavior (HP:0000719)	3.16886690
17	Agitation (HP:0000713)	3.16450036
18	Acute hepatic failure (HP:0006554)	3.09423450
19	Abnormality of cells of the erythroid lineage (HP:0012130)	3.03642076
20	Drooling (HP:0002307)	2.95618950
21	Irregular epiphyses (HP:0010582)	2.89078241
22	Oligomenorrhea (HP:0000876)	2.80878462
23	CNS hypomyelination (HP:0003429)	2.80254216
24	Increased hepatocellular lipid droplets (HP:0006565)	2.79314300
25	Excessive salivation (HP:0003781)	2.75263995
26	Hyperglycinemia (HP:0002154)	2.70043381
27	Macrocytic anemia (HP:0001972)	2.69607777
28	Carpal bone hypoplasia (HP:0001498)	2.69172127
29	Lissencephaly (HP:0001339)	2.69017761
30	Acute necrotizing encephalopathy (HP:0006965)	2.67402455
31	Type II lissencephaly (HP:0007260)	2.65787763
32	Abnormality of midbrain morphology (HP:0002418)	2.52537276
33	Molar tooth sign on MRI (HP:0002419)	2.52537276
34	Elevated erythrocyte sedimentation rate (HP:0003565)	2.50756140
35	Abnormal number of erythroid precursors (HP:0012131)	2.46861973
36	Anencephaly (HP:0002323)	2.44889615
37	Decreased muscle mass (HP:0003199)	2.41386633
38	Psychosis (HP:0000709)	2.41254475
39	Lipid accumulation in hepatocytes (HP:0006561)	2.40442277
40	Type 2 muscle fiber atrophy (HP:0003554)	2.28326803
41	Acute encephalopathy (HP:0006846)	2.25992942
42	Abolished electroretinogram (ERG) (HP:0000550)	2.23873020
43	Medial flaring of the eyebrow (HP:0010747)	2.22673970
44	Renal Fanconi syndrome (HP:0001994)	2.20850734
45	Optic disc pallor (HP:0000543)	2.19154235
46	Septo-optic dysplasia (HP:0100842)	2.16760731
47	Abnormal mitochondria in muscle tissue (HP:0008316)	2.15002460
48	Pancreatic fibrosis (HP:0100732)	2.13089647
49	Macular degeneration (HP:0000608)	2.09419080
50	Progressive macrocephaly (HP:0004481)	2.09042108
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.08783165
52	Absent thumb (HP:0009777)	2.08055454
53	Asplenia (HP:0001746)	2.06058313
54	Muscle fiber atrophy (HP:0100295)	2.01708118
55	Stenosis of the external auditory canal (HP:0000402)	2.01314710
56	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.00949756
57	Mitochondrial inheritance (HP:0001427)	2.00527903
58	Upper motor neuron abnormality (HP:0002127)	1.97225000
59	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.96440159
60	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.96069401
61	Hypoplasia of the brainstem (HP:0002365)	1.96069401
62	Disproportionate short-trunk short stature (HP:0003521)	1.92067211
63	Poikilocytosis (HP:0004447)	1.92044748
64	Retinal dysplasia (HP:0007973)	1.90944598
65	Hyperphosphaturia (HP:0003109)	1.89106088
66	True hermaphroditism (HP:0010459)	1.89072965
67	IgG deficiency (HP:0004315)	1.87719894
68	Congenital stationary night blindness (HP:0007642)	1.85442877
69	Premature ovarian failure (HP:0008209)	1.83192549
70	Delayed myelination (HP:0012448)	1.82860147
71	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.82331753
72	Absent/shortened dynein arms (HP:0200106)	1.82331753
73	Anxiety (HP:0000739)	1.81387077
74	Broad-based gait (HP:0002136)	1.80524176
75	Optic nerve hypoplasia (HP:0000609)	1.77504162
76	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.77450421
77	Hypoplasia of the radius (HP:0002984)	1.76871904
78	Restlessness (HP:0000711)	1.75730881
79	Rhinitis (HP:0012384)	1.75417405
80	Increased CSF lactate (HP:0002490)	1.75306838
81	Hypoplasia of the ulna (HP:0003022)	1.74819752
82	Maternal diabetes (HP:0009800)	1.73231300
83	Choreoathetosis (HP:0001266)	1.72051969
84	Bony spicule pigmentary retinopathy (HP:0007737)	1.71417545
85	Abnormality of lateral ventricle (HP:0030047)	1.70944900
86	Spinal canal stenosis (HP:0003416)	1.69957580
87	Pachygyria (HP:0001302)	1.69320562
88	Delusions (HP:0000746)	1.68962443
89	Abnormal respiratory motile cilium physiology (HP:0012261)	1.68923676
90	Abnormality of the costochondral junction (HP:0000919)	1.67693884
91	Rib fusion (HP:0000902)	1.67278201
92	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	1.67025402
93	Stomatitis (HP:0010280)	1.65241819
94	Exertional dyspnea (HP:0002875)	1.64083979
95	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.63788792
96	Pancreatic cysts (HP:0001737)	1.63640239
97	Porencephaly (HP:0002132)	1.63252046
98	Nephronophthisis (HP:0000090)	1.63037680
99	Delayed CNS myelination (HP:0002188)	1.62610244
100	Infertility (HP:0000789)	1.61866307

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	6.98941124
2	MAP4K1	4.31705353
3	BMPR1B	3.53577990
4	WNK3	3.28200464
5	EPHB2	2.95839866
6	RIPK4	2.62892954
7	MAP3K11	2.18384488
8	DYRK2	2.11030324
9	NTRK2	2.07438105
10	WNK4	1.99433263
11	GRK1	1.86159118
12	GRK6	1.84095766
13	ADRBK2	1.71759060
14	TXK	1.66468928
15	MAP3K4	1.53906847
16	BMPR2	1.53030623
17	TLK1	1.51439538
18	PRKCG	1.45377730
19	PINK1	1.37036003
20	RPS6KA6	1.28394589
21	MAP2K7	1.23909588
22	ZAK	1.22984628
23	FRK	1.19794658
24	LRRK2	1.16964206
25	STK39	1.13732337
26	MARK1	1.11879812
27	DYRK1B	1.08377217
28	CAMK1	1.06545648
29	RPS6KC1	1.06477526
30	RPS6KL1	1.06477526
31	TNIK	1.05822425
32	TIE1	1.00985996
33	PASK	1.00871385
34	OXSR1	1.00567917
35	PRKCQ	0.97265898
36	PIM2	0.93147368
37	AURKA	0.93102223
38	PRKACA	0.92829084
39	INSRR	0.90569548
40	PKN1	0.88904752
41	MAPK13	0.84377738
42	VRK1	0.81492322
43	TYRO3	0.75170810
44	STK11	0.73987665
45	MAPK15	0.72854609
46	TEC	0.72213582
47	PRKCZ	0.71605181
48	TGFBR1	0.71143776
49	BCKDK	0.71051747
50	CAMKK1	0.70652840
51	PLK1	0.70175031
52	MUSK	0.69532252
53	NUAK1	0.69437673
54	NME1	0.68653827
55	OBSCN	0.66851496
56	PLK2	0.66484327
57	PIM1	0.64384953
58	MARK2	0.62533871
59	RPS6KA5	0.61617403
60	CSK	0.61563063
61	VRK2	0.61199897
62	ADRBK1	0.60876807
63	STK16	0.59208480
64	PAK3	0.58354134
65	CSNK2A2	0.57465273
66	PRKACG	0.55313414
67	CAMK4	0.55023659
68	CSNK2A1	0.53809723
69	CDC7	0.53487983
70	GRK5	0.52191319
71	SIK2	0.51100458
72	CAMK2A	0.50094603
73	TAOK3	0.49914661
74	LCK	0.48829681
75	CDK19	0.48557511
76	NEK9	0.48142673
77	PRKCA	0.48031484
78	PRKD2	0.46476646
79	CSNK1A1	0.45410003
80	AURKB	0.44999315
81	CSNK1D	0.44581481
82	DAPK3	0.44278622
83	CHEK1	0.42195760
84	PIK3CA	0.41132393
85	RPS6KA3	0.39851201
86	EPHA4	0.39127014
87	PLK4	0.39081917
88	DMPK	0.37873464
89	RPS6KB1	0.37576987
90	CSNK1E	0.37444643
91	GRK7	0.37239060
92	PRKCH	0.36939098
93	IKBKB	0.36689394
94	CHEK2	0.36607341
95	SGK1	0.36104801
96	TAF1	0.34933248
97	PRKCI	0.34416155
98	PRKDC	0.34377694
99	PRKCE	0.34300476
100	CASK	0.33131699

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.77047858
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.10891917
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.00300584
4	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.51667003
5	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.31567953
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.30901707
7	Parkinsons disease_Homo sapiens_hsa05012	2.24078428
8	RNA degradation_Homo sapiens_hsa03018	2.17412746
9	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.05548429
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.00806061
11	Alzheimers disease_Homo sapiens_hsa05010	1.85192225
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.84275892
13	Nicotine addiction_Homo sapiens_hsa05033	1.77787256
14	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77657122
15	Huntingtons disease_Homo sapiens_hsa05016	1.68401208
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.67330895
17	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.61789445
18	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.59909213
19	RNA polymerase_Homo sapiens_hsa03020	1.59648308
20	Sulfur relay system_Homo sapiens_hsa04122	1.58245012
21	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.57920572
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.57459943
23	Asthma_Homo sapiens_hsa05310	1.55004909
24	Olfactory transduction_Homo sapiens_hsa04740	1.48879232
25	Homologous recombination_Homo sapiens_hsa03440	1.39713441
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.36647075
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.34615586
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.28199470
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.25005799
30	Insulin secretion_Homo sapiens_hsa04911	1.23258318
31	Caffeine metabolism_Homo sapiens_hsa00232	1.17829597
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15336755
33	One carbon pool by folate_Homo sapiens_hsa00670	1.11345108
34	Protein export_Homo sapiens_hsa03060	1.04493673
35	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01853200
36	Tryptophan metabolism_Homo sapiens_hsa00380	0.98838360
37	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.97444338
38	Allograft rejection_Homo sapiens_hsa05330	0.95649567
39	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.95187764
40	Taste transduction_Homo sapiens_hsa04742	0.94348124
41	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.94011914
42	Morphine addiction_Homo sapiens_hsa05032	0.89824982
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89194002
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.88691575
45	Basal transcription factors_Homo sapiens_hsa03022	0.87875220
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.87602575
47	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82358333
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.81086224
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79915868
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.76732585
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76673961
52	Selenocompound metabolism_Homo sapiens_hsa00450	0.74371542
53	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.74178182
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.72905128
55	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.71933650
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.70796538
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.70773056
58	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69756087
59	Salivary secretion_Homo sapiens_hsa04970	0.69567134
60	Mismatch repair_Homo sapiens_hsa03430	0.67151351
61	Phototransduction_Homo sapiens_hsa04744	0.67078529
62	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66571750
63	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.64715006
64	Mineral absorption_Homo sapiens_hsa04978	0.61897523
65	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.61570619
66	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61366326
67	Axon guidance_Homo sapiens_hsa04360	0.60070082
68	Retinol metabolism_Homo sapiens_hsa00830	0.59909972
69	ABC transporters_Homo sapiens_hsa02010	0.57763984
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56496507
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.56272332
72	Type I diabetes mellitus_Homo sapiens_hsa04940	0.55002076
73	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.53392819
74	Metabolic pathways_Homo sapiens_hsa01100	0.52531479
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51923972
76	Purine metabolism_Homo sapiens_hsa00230	0.51816577
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51702992
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.49461035
79	Nitrogen metabolism_Homo sapiens_hsa00910	0.48945969
80	Serotonergic synapse_Homo sapiens_hsa04726	0.47692660
81	Basal cell carcinoma_Homo sapiens_hsa05217	0.46746080
82	Pancreatic secretion_Homo sapiens_hsa04972	0.46583645
83	DNA replication_Homo sapiens_hsa03030	0.46348456
84	Protein digestion and absorption_Homo sapiens_hsa04974	0.43264157
85	Notch signaling pathway_Homo sapiens_hsa04330	0.42587361
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.42126845
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.40405827
88	Gastric acid secretion_Homo sapiens_hsa04971	0.39850497
89	GABAergic synapse_Homo sapiens_hsa04727	0.38009933
90	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.37394202
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.36618672
92	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.35704904
93	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.34820059
94	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.34618774
95	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.34321229
96	Circadian entrainment_Homo sapiens_hsa04713	0.33296314
97	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.31622910
98	Histidine metabolism_Homo sapiens_hsa00340	0.30618721
99	RNA transport_Homo sapiens_hsa03013	0.30492589
100	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30453438

RPL36AP55

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »