ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	9.55436493
2	viral transcription (GO:0019083)	9.11770532
3	translational termination (GO:0006415)	8.71184070
4	maturation of SSU-rRNA (GO:0030490)	7.87323019
5	ribosomal small subunit assembly (GO:0000028)	7.61239757
6	translational elongation (GO:0006414)	7.40458345
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.34595539
8	cotranslational protein targeting to membrane (GO:0006613)	7.23164779
9	protein targeting to ER (GO:0045047)	7.22123055
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.96753216
11	protein localization to endoplasmic reticulum (GO:0070972)	6.82165226
12	viral life cycle (GO:0019058)	6.65544580
13	cellular protein complex disassembly (GO:0043624)	6.61104795
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.41940506
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.04619672
16	ATP synthesis coupled proton transport (GO:0015986)	6.04619672
17	chaperone-mediated protein transport (GO:0072321)	5.95594905
18	protein complex disassembly (GO:0043241)	5.69584639
19	translational initiation (GO:0006413)	5.62567715
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.46199452
21	macromolecular complex disassembly (GO:0032984)	5.30266769
22	GTP biosynthetic process (GO:0006183)	4.96563992
23	protein targeting to membrane (GO:0006612)	4.95325340
24	ribosomal large subunit biogenesis (GO:0042273)	4.92782833
25	translation (GO:0006412)	4.90372908
26	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.88253916
27	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.75140842
28	UTP biosynthetic process (GO:0006228)	4.58688112
29	respiratory electron transport chain (GO:0022904)	4.48501947
30	electron transport chain (GO:0022900)	4.46298798
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.44706672
32	ribonucleoprotein complex biogenesis (GO:0022613)	4.44654204
33	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.43963713
34	pyrimidine nucleotide catabolic process (GO:0006244)	4.26564184
35	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.23426717
36	NADH dehydrogenase complex assembly (GO:0010257)	4.23426717
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.23426717
38	mRNA catabolic process (GO:0006402)	4.19999822
39	UTP metabolic process (GO:0046051)	4.19369523
40	substrate-independent telencephalic tangential migration (GO:0021826)	4.15536163
41	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.15536163
42	cellular component biogenesis (GO:0044085)	4.14986995
43	protein complex biogenesis (GO:0070271)	4.14051872
44	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	4.12105113
45	purine nucleoside triphosphate biosynthetic process (GO:0009145)	4.00677121
46	protein neddylation (GO:0045116)	4.00237221
47	mitochondrial respiratory chain complex assembly (GO:0033108)	3.87777706
48	ATP biosynthetic process (GO:0006754)	3.85433888
49	response to gravity (GO:0009629)	3.78078579
50	CTP metabolic process (GO:0046036)	3.77213087
51	CTP biosynthetic process (GO:0006241)	3.77213087
52	RNA catabolic process (GO:0006401)	3.76635056
53	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.76130139
54	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.71266961
55	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.68264401
56	base-excision repair, AP site formation (GO:0006285)	3.63392963
57	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	3.56488891
58	nonmotile primary cilium assembly (GO:0035058)	3.53082465
59	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.48707843
60	establishment of protein localization to membrane (GO:0090150)	3.47384767
61	protein targeting (GO:0006605)	3.47253245
62	pattern specification involved in kidney development (GO:0061004)	3.36885334
63	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.32896206
64	regulation of mitochondrial translation (GO:0070129)	3.30693923
65	cell proliferation in forebrain (GO:0021846)	3.29952953
66	protein targeting to mitochondrion (GO:0006626)	3.27040711
67	guanosine-containing compound biosynthetic process (GO:1901070)	3.24668646
68	respiratory tube development (GO:0030323)	3.22733512
69	rRNA processing (GO:0006364)	3.21364430
70	nucleoside triphosphate biosynthetic process (GO:0009142)	3.21224234
71	establishment of protein localization to organelle (GO:0072594)	3.16104820
72	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.15589965
73	ncRNA 3-end processing (GO:0043628)	3.13351052
74	behavioral response to nicotine (GO:0035095)	3.12393609
75	rRNA metabolic process (GO:0016072)	3.08970117
76	hydrogen ion transmembrane transport (GO:1902600)	3.07802100
77	termination of RNA polymerase III transcription (GO:0006386)	3.03993196
78	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03993196
79	establishment of protein localization to mitochondrion (GO:0072655)	3.02558076
80	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.94126055
81	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.94126055
82	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.87034768
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.85868068
84	regulation of cilium movement (GO:0003352)	2.84906925
85	peptidyl-histidine modification (GO:0018202)	2.82125918
86	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.82104565
87	cardiovascular system development (GO:0072358)	2.79533568
88	pseudouridine synthesis (GO:0001522)	2.79478725
89	nucleoside diphosphate phosphorylation (GO:0006165)	2.79000206
90	protein localization to mitochondrion (GO:0070585)	2.75660782
91	deoxyribonucleotide catabolic process (GO:0009264)	2.70331897
92	negative regulation of T cell differentiation in thymus (GO:0033085)	2.69365281
93	proton transport (GO:0015992)	2.68215340
94	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.66609637
95	myoblast migration (GO:0051451)	2.66240690
96	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.65236431
97	protein localization to membrane (GO:0072657)	2.64241018
98	lens fiber cell development (GO:0070307)	2.62205851
99	hydrogen transport (GO:0006818)	2.61560352
100	protein polyglutamylation (GO:0018095)	2.58045099

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.22949775
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.05206770
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.56796565
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.25287997
5	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.20847845
6	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.08875967
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03285382
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.00353934
9	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.83282472
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.67442452
11	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.63629765
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49816501
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.31056272
14	XRN2_22483619_ChIP-Seq_HELA_Human	2.21440817
15	TTF2_22483619_ChIP-Seq_HELA_Human	2.20018208
16	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.16756636
17	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.04556297
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.03739249
19	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	2.01864184
20	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.98466583
21	GABP_19822575_ChIP-Seq_HepG2_Human	1.97699148
22	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.94987751
23	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.94567171
24	VDR_22108803_ChIP-Seq_LS180_Human	1.85073115
25	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.83284868
26	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.73282906
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.71678608
28	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.71452895
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.68538912
30	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.62696625
31	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.60331200
32	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.56995590
33	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.55156898
34	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.51142070
35	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.50945210
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.50821536
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.50125756
38	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.50097247
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.50043377
40	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.49673214
41	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.49366842
42	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.48232167
43	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.40982035
44	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.39855005
45	FOXP3_21729870_ChIP-Seq_TREG_Human	1.37401359
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35221479
47	DCP1A_22483619_ChIP-Seq_HELA_Human	1.34327510
48	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.33918082
49	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.30696625
50	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.30533549
51	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30075129
52	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.27904433
53	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.26850419
54	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.26850419
55	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.26850419
56	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.25759865
57	BCL6_27268052_Chip-Seq_Bcells_Human	1.24546841
58	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.23437204
59	MYC_18940864_ChIP-ChIP_HL60_Human	1.21545195
60	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.21365821
61	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.21317196
62	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.19454950
63	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.18449338
64	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.18359366
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.17515840
66	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.14762142
67	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.13664567
68	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.12870479
69	P68_20966046_ChIP-Seq_HELA_Human	1.12266092
70	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.11150509
71	CTCF_20526341_ChIP-Seq_ESCs_Human	1.10324572
72	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.08842808
73	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.07646496
74	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06502959
75	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05524008
76	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04826872
77	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.04036461
78	ERA_21632823_ChIP-Seq_H3396_Human	1.02981216
79	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02458366
80	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01992545
81	CTCF_27219007_Chip-Seq_Bcells_Human	1.00782691
82	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	0.98030904
83	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	0.97092858
84	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.97049722
85	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.96812892
86	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.96812892
87	E2F1_20622854_ChIP-Seq_HELA_Human	0.96594818
88	ELK1_19687146_ChIP-ChIP_HELA_Human	0.94684576
89	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.93638223
90	ZNF274_21170338_ChIP-Seq_K562_Hela	0.93420489
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.91495902
92	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.91063070
93	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.90950730
94	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.89465248
95	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.88945063
96	NANOG_20526341_ChIP-Seq_ESCs_Human	0.85206839
97	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.84740338
98	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.84363510
99	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.84206302
100	TP53_22573176_ChIP-Seq_HFKS_Human	0.83305796

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.93830326
2	MP0006292_abnormal_olfactory_placode	3.73607035
3	MP0008789_abnormal_olfactory_epithelium	3.32729521
4	MP0003123_paternal_imprinting	2.98951912
5	MP0010030_abnormal_orbit_morphology	2.97320057
6	MP0002653_abnormal_ependyma_morphology	2.92286268
7	MP0005646_abnormal_pituitary_gland	2.82525833
8	MP0005499_abnormal_olfactory_system	2.63298617
9	MP0005394_taste/olfaction_phenotype	2.63298617
10	MP0004145_abnormal_muscle_electrophysio	2.41739227
11	MP0000049_abnormal_middle_ear	2.37855517
12	MP0003122_maternal_imprinting	2.16771634
13	MP0002163_abnormal_gland_morphology	2.02523537
14	MP0004142_abnormal_muscle_tone	2.02389080
15	MP0003315_abnormal_perineum_morphology	1.88853361
16	MP0000566_synostosis	1.82186532
17	MP0003121_genomic_imprinting	1.80649141
18	MP0001346_abnormal_lacrimal_gland	1.66166494
19	MP0006276_abnormal_autonomic_nervous	1.64990762
20	MP0004885_abnormal_endolymph	1.64236139
21	MP0001984_abnormal_olfaction	1.60050689
22	MP0000013_abnormal_adipose_tissue	1.59993638
23	MP0002234_abnormal_pharynx_morphology	1.58324104
24	MP0003646_muscle_fatigue	1.57288560
25	MP0001529_abnormal_vocalization	1.51880523
26	MP0009250_abnormal_appendicular_skeleto	1.43432721
27	MP0002102_abnormal_ear_morphology	1.42501227
28	MP0000750_abnormal_muscle_regeneration	1.38374097
29	MP0001485_abnormal_pinna_reflex	1.35360416
30	MP0002837_dystrophic_cardiac_calcinosis	1.31838673
31	MP0001968_abnormal_touch/_nociception	1.29790084
32	MP0000778_abnormal_nervous_system	1.29112500
33	MP0002736_abnormal_nociception_after	1.26206430
34	MP0002160_abnormal_reproductive_system	1.23390549
35	MP0002095_abnormal_skin_pigmentation	1.19636572
36	MP0004858_abnormal_nervous_system	1.19110115
37	MP0000026_abnormal_inner_ear	1.18601326
38	MP0003787_abnormal_imprinting	1.18410534
39	MP0003879_abnormal_hair_cell	1.14583250
40	MP0005551_abnormal_eye_electrophysiolog	1.11817868
41	MP0005195_abnormal_posterior_eye	1.08794493
42	MP0009046_muscle_twitch	1.06850832
43	MP0004742_abnormal_vestibular_system	1.06728596
44	MP0002233_abnormal_nose_morphology	1.06384390
45	MP0002184_abnormal_innervation	1.05227825
46	MP0000631_abnormal_neuroendocrine_gland	1.03945061
47	MP0003755_abnormal_palate_morphology	1.03652010
48	MP0003186_abnormal_redox_activity	1.02814735
49	MP0002938_white_spotting	1.02590561
50	MP0005670_abnormal_white_adipose	1.01229212
51	MP0008875_abnormal_xenobiotic_pharmacok	1.01053915
52	MP0002752_abnormal_somatic_nervous	1.00488490
53	MP0000678_abnormal_parathyroid_gland	1.00190761
54	MP0002272_abnormal_nervous_system	0.98951032
55	MP0004133_heterotaxia	0.97579776
56	MP0005377_hearing/vestibular/ear_phenot	0.96988234
57	MP0003878_abnormal_ear_physiology	0.96988234
58	MP0002210_abnormal_sex_determination	0.96797881
59	MP0000003_abnormal_adipose_tissue	0.96535662
60	MP0001293_anophthalmia	0.96349853
61	MP0001963_abnormal_hearing_physiology	0.95470788
62	MP0008775_abnormal_heart_ventricle	0.94382795
63	MP0005083_abnormal_biliary_tract	0.92046904
64	MP0005389_reproductive_system_phenotype	0.91775813
65	MP0002876_abnormal_thyroid_physiology	0.90398391
66	MP0005408_hypopigmentation	0.89874168
67	MP0001502_abnormal_circadian_rhythm	0.89733331
68	MP0002733_abnormal_thermal_nociception	0.89715680
69	MP0009745_abnormal_behavioral_response	0.89564107
70	MP0002249_abnormal_larynx_morphology	0.89058443
71	MP0000955_abnormal_spinal_cord	0.88662582
72	MP0001970_abnormal_pain_threshold	0.88511093
73	MP0003942_abnormal_urinary_system	0.87910613
74	MP0003938_abnormal_ear_development	0.86009162
75	MP0009278_abnormal_bone_marrow	0.85497324
76	MP0003937_abnormal_limbs/digits/tail_de	0.84984486
77	MP0009053_abnormal_anal_canal	0.83078965
78	MP0008004_abnormal_stomach_pH	0.82117901
79	MP0002557_abnormal_social/conspecific_i	0.81874588
80	MP0008877_abnormal_DNA_methylation	0.81591373
81	MP0006072_abnormal_retinal_apoptosis	0.81479222
82	MP0002277_abnormal_respiratory_mucosa	0.80301030
83	MP0003693_abnormal_embryo_hatching	0.79471895
84	MP0006036_abnormal_mitochondrial_physio	0.79438037
85	MP0002177_abnormal_outer_ear	0.79407385
86	MP0001919_abnormal_reproductive_system	0.78322182
87	MP0002116_abnormal_craniofacial_bone	0.78135353
88	MP0000534_abnormal_ureter_morphology	0.77788860
89	MP0005379_endocrine/exocrine_gland_phen	0.71124879
90	MP0001905_abnormal_dopamine_level	0.69728058
91	MP0002882_abnormal_neuron_morphology	0.69305092
92	MP0003959_abnormal_lean_body	0.68540018
93	MP0000762_abnormal_tongue_morphology	0.68474872
94	MP0001542_abnormal_bone_strength	0.66888433
95	MP0003786_premature_aging	0.66546017
96	MP0002572_abnormal_emotion/affect_behav	0.66500354
97	MP0003936_abnormal_reproductive_system	0.65263762
98	MP0002064_seizures	0.65207191
99	MP0004147_increased_porphyrin_level	0.64413322
100	MP0008872_abnormal_physiological_respon	0.64354884

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.53479937
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.45004715
3	Acute necrotizing encephalopathy (HP:0006965)	4.89240439
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.40200813
5	Acute encephalopathy (HP:0006846)	4.18288719
6	Abnormal number of erythroid precursors (HP:0012131)	4.16933897
7	Mitochondrial inheritance (HP:0001427)	4.05136216
8	Macrocytic anemia (HP:0001972)	4.01938605
9	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.00974527
10	Progressive macrocephaly (HP:0004481)	3.91038913
11	Microretrognathia (HP:0000308)	3.88874488
12	Abnormality of midbrain morphology (HP:0002418)	3.87919726
13	Molar tooth sign on MRI (HP:0002419)	3.87919726
14	Increased CSF lactate (HP:0002490)	3.47078736
15	Renal Fanconi syndrome (HP:0001994)	3.31443124
16	Pallor (HP:0000980)	3.11816959
17	Increased hepatocellular lipid droplets (HP:0006565)	3.08958312
18	Pancreatic fibrosis (HP:0100732)	3.02417115
19	Hepatocellular necrosis (HP:0001404)	3.00337278
20	Partial duplication of thumb phalanx (HP:0009944)	2.98044733
21	Cerebral edema (HP:0002181)	2.95246428
22	Broad distal phalanx of finger (HP:0009836)	2.88573037
23	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.75018671
24	Increased intramyocellular lipid droplets (HP:0012240)	2.66619169
25	Stenosis of the external auditory canal (HP:0000402)	2.66531257
26	Lipid accumulation in hepatocytes (HP:0006561)	2.64774252
27	Hepatic necrosis (HP:0002605)	2.64172442
28	Myokymia (HP:0002411)	2.58737626
29	3-Methylglutaconic aciduria (HP:0003535)	2.57056704
30	Partial duplication of the phalanx of hand (HP:0009999)	2.55816520
31	Pancreatic cysts (HP:0001737)	2.54060865
32	Hypoplasia of the radius (HP:0002984)	2.54037304
33	Medial flaring of the eyebrow (HP:0010747)	2.51536275
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.51495478
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.51495478
36	Sclerocornea (HP:0000647)	2.48839567
37	Hyperthyroidism (HP:0000836)	2.48169177
38	Absent thumb (HP:0009777)	2.45862352
39	True hermaphroditism (HP:0010459)	2.45273212
40	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.44690114
41	Type II lissencephaly (HP:0007260)	2.41154826
42	Anencephaly (HP:0002323)	2.39466887
43	Optic disc pallor (HP:0000543)	2.37468121
44	Septo-optic dysplasia (HP:0100842)	2.36689519
45	Maternal diabetes (HP:0009800)	2.33182853
46	Exercise intolerance (HP:0003546)	2.31511448
47	Lactic acidosis (HP:0003128)	2.23172394
48	Abnormal number of incisors (HP:0011064)	2.22856931
49	Depressed nasal ridge (HP:0000457)	2.18743254
50	Colon cancer (HP:0003003)	2.18174530
51	Increased serum lactate (HP:0002151)	2.17515204
52	Respiratory failure (HP:0002878)	2.15829438
53	Congenital stationary night blindness (HP:0007642)	2.15468849
54	Hyperglycinemia (HP:0002154)	2.15260999
55	Down-sloping shoulders (HP:0200021)	2.10371281
56	Increased muscle lipid content (HP:0009058)	2.08346300
57	Exertional dyspnea (HP:0002875)	2.05862231
58	Abnormality of renal resorption (HP:0011038)	2.03618137
59	Anophthalmia (HP:0000528)	2.02937162
60	Gait imbalance (HP:0002141)	2.02926327
61	Abnormality of magnesium homeostasis (HP:0004921)	2.00166704
62	Congenital primary aphakia (HP:0007707)	1.96539663
63	Nephrogenic diabetes insipidus (HP:0009806)	1.96443175
64	11 pairs of ribs (HP:0000878)	1.95759199
65	Abnormal hemoglobin (HP:0011902)	1.95558190
66	Preaxial hand polydactyly (HP:0001177)	1.95432380
67	Abnormal drinking behavior (HP:0030082)	1.95120440
68	Polydipsia (HP:0001959)	1.95120440
69	Abnormal rod and cone electroretinograms (HP:0008323)	1.95077921
70	Patent foramen ovale (HP:0001655)	1.94953026
71	Severe muscular hypotonia (HP:0006829)	1.93833656
72	Cystic liver disease (HP:0006706)	1.92820156
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.92221557
74	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.91911207
75	Flat capital femoral epiphysis (HP:0003370)	1.90389596
76	Anterior segment dysgenesis (HP:0007700)	1.89480132
77	Holoprosencephaly (HP:0001360)	1.86819533
78	Cleft eyelid (HP:0000625)	1.86652314
79	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.85665093
80	Asplenia (HP:0001746)	1.85641455
81	Adrenal hypoplasia (HP:0000835)	1.85557632
82	Occipital encephalocele (HP:0002085)	1.84912127
83	Postaxial foot polydactyly (HP:0001830)	1.84786630
84	Forearm undergrowth (HP:0009821)	1.84496898
85	Abnormality of the phalanges of the hallux (HP:0010057)	1.83881975
86	Leukodystrophy (HP:0002415)	1.83526541
87	Absent septum pellucidum (HP:0001331)	1.81667583
88	Type 2 muscle fiber atrophy (HP:0003554)	1.81397816
89	X-linked dominant inheritance (HP:0001423)	1.81393405
90	Nephronophthisis (HP:0000090)	1.79959291
91	Muscle fiber atrophy (HP:0100295)	1.74390460
92	Respiratory difficulties (HP:0002880)	1.72607325
93	Abnormality of the renal medulla (HP:0100957)	1.71569848
94	Optic nerve coloboma (HP:0000588)	1.71108742
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.70813286
96	Aganglionic megacolon (HP:0002251)	1.70541076
97	Rib fusion (HP:0000902)	1.69241310
98	Polyuria (HP:0000103)	1.68004423
99	Triphalangeal thumb (HP:0001199)	1.67466022
100	Abnormality of the renal cortex (HP:0011035)	1.67352738

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.52312416
2	BCKDK	4.13094981
3	ZAK	3.74059028
4	TLK1	3.03976913
5	LRRK2	3.02802967
6	CASK	2.82745184
7	WNK4	2.55637643
8	EPHB2	2.18694218
9	STK16	2.14185731
10	DYRK2	2.10199248
11	MAP2K7	1.99388521
12	PHKG2	1.86306197
13	PHKG1	1.86306197
14	LIMK1	1.85824653
15	PIK3CA	1.63452788
16	VRK2	1.62391692
17	AURKA	1.56281193
18	ADRBK2	1.55328026
19	CDK19	1.54594649
20	CDC7	1.47988980
21	NUAK1	1.40958438
22	CAMK1D	1.37799575
23	TIE1	1.36626182
24	CAMKK2	1.36178392
25	GRK1	1.33695761
26	WNK3	1.30513747
27	PDK2	1.24852787
28	VRK1	1.24671823
29	DYRK1B	1.24451927
30	ABL2	1.16628496
31	KDR	1.10725971
32	WNK1	1.08462777
33	ILK	1.07536025
34	PINK1	1.06861511
35	CHEK2	1.06221619
36	DAPK3	1.06159856
37	TYRO3	1.03829237
38	PRKCG	0.97423648
39	RPS6KA5	0.95519395
40	PLK4	0.93723848
41	PRKCI	0.92394096
42	OBSCN	0.91816183
43	AURKB	0.89828474
44	MAP3K11	0.89552701
45	PIM2	0.87441386
46	TESK2	0.86471120
47	BRAF	0.83775582
48	CAMK1	0.82837430
49	CAMK1G	0.82570679
50	DMPK	0.80287326
51	ADRBK1	0.77289123
52	CSNK2A2	0.75569356
53	PTK6	0.71650039
54	PLK1	0.70938499
55	EPHA4	0.67900429
56	CSNK1G2	0.63417479
57	CDK11A	0.62752190
58	STK39	0.62407823
59	INSRR	0.62096112
60	MUSK	0.61963807
61	CSNK1G3	0.61201644
62	MINK1	0.60656458
63	NME1	0.60352410
64	AKT2	0.60241072
65	CAMKK1	0.60233612
66	DAPK2	0.57963098
67	CDK15	0.56184289
68	CSNK2A1	0.56062387
69	PAK1	0.56011085
70	PIM1	0.54961973
71	NEK1	0.54671523
72	NTRK2	0.54552074
73	MAPK13	0.53899869
74	DAPK1	0.53499762
75	PRKACA	0.52734646
76	TESK1	0.52467943
77	ARAF	0.52413273
78	BMPR1B	0.52074268
79	PRKCQ	0.52063824
80	CDK14	0.51229201
81	ATR	0.50716934
82	CSNK1E	0.50053023
83	PRKCH	0.50006496
84	STK11	0.48502680
85	CDK18	0.48025910
86	PRKCD	0.46730809
87	MOS	0.46584726
88	RPS6KA6	0.44887199
89	BCR	0.40698159
90	MAPK15	0.40113475
91	PAK6	0.39761052
92	MAP3K8	0.39550007
93	PRKCZ	0.36846368
94	PAK3	0.36549730
95	MAP3K4	0.36420182
96	CSNK1A1	0.34323882
97	CCNB1	0.34092404
98	FRK	0.33711680
99	MAP4K2	0.32855142
100	PKN1	0.32740969

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.98471427
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.90355203
3	Parkinsons disease_Homo sapiens_hsa05012	4.15809152
4	Huntingtons disease_Homo sapiens_hsa05016	3.24466894
5	Cardiac muscle contraction_Homo sapiens_hsa04260	3.09344969
6	Alzheimers disease_Homo sapiens_hsa05010	3.03048127
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.90554168
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.54517985
9	RNA polymerase_Homo sapiens_hsa03020	2.49709801
10	Base excision repair_Homo sapiens_hsa03410	2.27680411
11	DNA replication_Homo sapiens_hsa03030	2.14823316
12	Pyrimidine metabolism_Homo sapiens_hsa00240	1.89815731
13	Mismatch repair_Homo sapiens_hsa03430	1.70661303
14	Sulfur relay system_Homo sapiens_hsa04122	1.68798483
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.56981940
16	Proteasome_Homo sapiens_hsa03050	1.47435473
17	Protein export_Homo sapiens_hsa03060	1.34980123
18	Homologous recombination_Homo sapiens_hsa03440	1.29828969
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.26736900
20	RNA degradation_Homo sapiens_hsa03018	1.26068200
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.25676324
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22712003
23	Spliceosome_Homo sapiens_hsa03040	1.22047058
24	One carbon pool by folate_Homo sapiens_hsa00670	1.17363656
25	Basal cell carcinoma_Homo sapiens_hsa05217	1.16526419
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.10312468
27	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.09523915
28	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.09350421
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.02652032
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.00436095
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.94178699
32	Folate biosynthesis_Homo sapiens_hsa00790	0.91578022
33	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.87147204
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84262289
35	Purine metabolism_Homo sapiens_hsa00230	0.83967793
36	RNA transport_Homo sapiens_hsa03013	0.79745996
37	Metabolic pathways_Homo sapiens_hsa01100	0.79368609
38	Phototransduction_Homo sapiens_hsa04744	0.75546551
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.73413033
40	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.66642317
41	Peroxisome_Homo sapiens_hsa04146	0.65118263
42	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.63331065
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.63160904
44	Basal transcription factors_Homo sapiens_hsa03022	0.60483227
45	Caffeine metabolism_Homo sapiens_hsa00232	0.59622602
46	Glutathione metabolism_Homo sapiens_hsa00480	0.59155076
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.55433530
48	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55418975
49	Tyrosine metabolism_Homo sapiens_hsa00350	0.53639788
50	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.51349192
51	Chemical carcinogenesis_Homo sapiens_hsa05204	0.50444823
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.49059088
53	Butanoate metabolism_Homo sapiens_hsa00650	0.48583892
54	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.48544454
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.48513578
56	Regulation of autophagy_Homo sapiens_hsa04140	0.48239047
57	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44700783
58	Arginine and proline metabolism_Homo sapiens_hsa00330	0.43282704
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.43223673
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.42511068
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42436284
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.41770010
63	Nicotine addiction_Homo sapiens_hsa05033	0.41592511
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.40211877
65	Morphine addiction_Homo sapiens_hsa05032	0.40185894
66	Phenylalanine metabolism_Homo sapiens_hsa00360	0.39147880
67	Fatty acid degradation_Homo sapiens_hsa00071	0.38924345
68	Galactose metabolism_Homo sapiens_hsa00052	0.38820238
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38207571
70	Steroid biosynthesis_Homo sapiens_hsa00100	0.34644779
71	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.34544398
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.33984240
73	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.33302372
74	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32418623
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.32122152
76	Nitrogen metabolism_Homo sapiens_hsa00910	0.31071213
77	Retinol metabolism_Homo sapiens_hsa00830	0.30705154
78	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.30526006
79	Insulin secretion_Homo sapiens_hsa04911	0.29059505
80	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28864367
81	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.28005170
82	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.27909332
83	Olfactory transduction_Homo sapiens_hsa04740	0.27598700
84	Ether lipid metabolism_Homo sapiens_hsa00565	0.26830176
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.26026183
86	Fatty acid elongation_Homo sapiens_hsa00062	0.25946637
87	Salivary secretion_Homo sapiens_hsa04970	0.24694475
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.24227395
89	Tight junction_Homo sapiens_hsa04530	0.23237142
90	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22661149
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.22226745
92	Axon guidance_Homo sapiens_hsa04360	0.20054210
93	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.18459422
94	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.18043058
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.16790914
96	p53 signaling pathway_Homo sapiens_hsa04115	0.14533704
97	Melanogenesis_Homo sapiens_hsa04916	0.12315715
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.11507302
99	Pancreatic secretion_Homo sapiens_hsa04972	0.10727511
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.10472125

RPL36AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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