ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of mast cell activation (GO:0033004)	7.16037843
2	regulation of activation of Janus kinase activity (GO:0010533)	6.26137181
3	viral transcription (GO:0019083)	5.91831834
4	ribosomal small subunit biogenesis (GO:0042274)	5.80676013
5	translational termination (GO:0006415)	5.61998718
6	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	5.58789493
7	mitochondrial respiratory chain complex I assembly (GO:0032981)	5.27453129
8	NADH dehydrogenase complex assembly (GO:0010257)	5.27453129
9	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	5.27453129
10	ribosomal small subunit assembly (GO:0000028)	5.27298459
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.90676204
12	ATP synthesis coupled proton transport (GO:0015986)	4.90644122
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.90644122
14	maturation of SSU-rRNA (GO:0030490)	4.86504555
15	DNA deamination (GO:0045006)	4.83825597
16	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.80779624
17	cotranslational protein targeting to membrane (GO:0006613)	4.77472079
18	translational elongation (GO:0006414)	4.75861678
19	protein targeting to ER (GO:0045047)	4.73691073
20	peptidyl-histidine modification (GO:0018202)	4.73198069
21	negative regulation of phagocytosis (GO:0050765)	4.63160993
22	protein localization to endoplasmic reticulum (GO:0070972)	4.58548378
23	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.51990044
24	cellular protein complex disassembly (GO:0043624)	4.35764616
25	maturation of 5.8S rRNA (GO:0000460)	4.21192830
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.20680744
27	viral life cycle (GO:0019058)	4.11556691
28	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.07532212
29	substrate-independent telencephalic tangential migration (GO:0021826)	4.07532212
30	behavioral response to nicotine (GO:0035095)	4.02419897
31	protein complex biogenesis (GO:0070271)	3.96748045
32	nonmotile primary cilium assembly (GO:0035058)	3.93453586
33	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.90147532
34	translational initiation (GO:0006413)	3.81774798
35	positive regulation of T cell apoptotic process (GO:0070234)	3.73827864
36	motile cilium assembly (GO:0044458)	3.69819549
37	epithelial cilium movement (GO:0003351)	3.68668088
38	kynurenine metabolic process (GO:0070189)	3.66880997
39	protein complex disassembly (GO:0043241)	3.58948182
40	chaperone-mediated protein transport (GO:0072321)	3.57824447
41	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.56906624
42	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.54923784
43	mitochondrial respiratory chain complex assembly (GO:0033108)	3.47451260
44	macromolecular complex disassembly (GO:0032984)	3.47373865
45	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.45243999
46	translation (GO:0006412)	3.37725237
47	preassembly of GPI anchor in ER membrane (GO:0016254)	3.36141257
48	indolalkylamine metabolic process (GO:0006586)	3.35280505
49	cell proliferation in forebrain (GO:0021846)	3.25215971
50	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.23627744
51	ribosomal large subunit biogenesis (GO:0042273)	3.19535746
52	protein targeting to membrane (GO:0006612)	3.17430876
53	interferon-gamma production (GO:0032609)	3.15147095
54	endoderm formation (GO:0001706)	3.14136554
55	negative regulation of telomere maintenance (GO:0032205)	3.13756299
56	protein neddylation (GO:0045116)	3.11866414
57	respiratory electron transport chain (GO:0022904)	3.10864597
58	mRNA catabolic process (GO:0006402)	3.09228746
59	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.09111713
60	microtubule severing (GO:0051013)	3.08580818
61	electron transport chain (GO:0022900)	3.08506413
62	tryptophan catabolic process (GO:0006569)	3.07703045
63	indole-containing compound catabolic process (GO:0042436)	3.07703045
64	indolalkylamine catabolic process (GO:0046218)	3.07703045
65	mannosylation (GO:0097502)	3.07474667
66	protein polyglutamylation (GO:0018095)	3.03860181
67	negative regulation of B cell proliferation (GO:0030889)	3.02450058
68	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	3.01596328
69	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.01107584
70	GPI anchor metabolic process (GO:0006505)	3.00013473
71	response to redox state (GO:0051775)	2.94027927
72	cellular component biogenesis (GO:0044085)	2.93514380
73	tryptophan metabolic process (GO:0006568)	2.90269922
74	termination of RNA polymerase I transcription (GO:0006363)	2.89368214
75	ATP biosynthetic process (GO:0006754)	2.83791654
76	fucose catabolic process (GO:0019317)	2.83408636
77	L-fucose metabolic process (GO:0042354)	2.83408636
78	L-fucose catabolic process (GO:0042355)	2.83408636
79	platelet dense granule organization (GO:0060155)	2.82148223
80	positive regulation of meiosis (GO:0045836)	2.78465363
81	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.78307942
82	RNA catabolic process (GO:0006401)	2.78260408
83	GPI anchor biosynthetic process (GO:0006506)	2.78121451
84	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.77612085
85	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.76701642
86	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.75498996
87	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.74399956
88	somite development (GO:0061053)	2.74391801
89	cilium movement (GO:0003341)	2.72491498
90	regulation of telomerase activity (GO:0051972)	2.71992889
91	termination of RNA polymerase III transcription (GO:0006386)	2.69700543
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.69700543
93	left/right axis specification (GO:0070986)	2.69019375
94	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.68899218
95	negative regulation of alpha-beta T cell activation (GO:0046636)	2.67372328
96	ribonucleoprotein complex biogenesis (GO:0022613)	2.65289947
97	regulation of cilium movement (GO:0003352)	2.62683315
98	intraciliary transport (GO:0042073)	2.62554742
99	GTP biosynthetic process (GO:0006183)	2.60942854
100	regulation of B cell receptor signaling pathway (GO:0050855)	2.60619148

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.90675125
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.55266670
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.17014788
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.04225263
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98174294
6	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.72931386
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.69381486
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.68338746
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.67856031
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.27414541
11	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.26845764
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.25966696
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.20565313
14	VDR_22108803_ChIP-Seq_LS180_Human	2.19421320
15	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.94603166
16	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92960535
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.87363519
18	MYC_18940864_ChIP-ChIP_HL60_Human	1.87144801
19	ELK1_19687146_ChIP-ChIP_HELA_Human	1.72101759
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.70521956
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.68476429
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.67256566
23	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.66937785
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.65936222
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62679515
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62157658
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.59098652
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.56963239
29	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55492457
30	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.54307214
31	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.51329376
32	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.50099043
33	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.45827740
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.45740219
35	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.44252942
36	TAF2_19829295_ChIP-Seq_ESCs_Human	1.43121716
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.42828735
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.41830439
39	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.41041715
40	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.39061226
41	GABP_19822575_ChIP-Seq_HepG2_Human	1.37613932
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.37221602
43	TTF2_22483619_ChIP-Seq_HELA_Human	1.36334155
44	XRN2_22483619_ChIP-Seq_HELA_Human	1.36247896
45	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.35957693
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.35554393
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.34456009
48	NCOR_22424771_ChIP-Seq_293T_Human	1.33337199
49	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.32463270
50	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.30880891
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.30616752
52	CTCF_20526341_ChIP-Seq_ESCs_Human	1.28726989
53	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.28477533
54	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.27332666
55	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27077637
56	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.26858893
57	BCL6_27268052_Chip-Seq_Bcells_Human	1.25434496
58	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.24955371
59	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.23557833
60	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.20008566
61	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.16871598
62	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16472954
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.15471625
64	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.13923359
65	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13471857
66	ERA_21632823_ChIP-Seq_H3396_Human	1.13441225
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.10850693
68	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.09316112
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08551855
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08401698
71	STAT1_20625510_ChIP-Seq_HELA_Human	1.08338358
72	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.08028363
73	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.07765540
74	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07447525
75	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07447525
76	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.06799714
77	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.06526852
78	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04603618
79	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02949812
80	AR_20517297_ChIP-Seq_VCAP_Human	1.01007892
81	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00967357
82	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.00771460
83	E2F1_20622854_ChIP-Seq_HELA_Human	1.00263329
84	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.99688816
85	P300_27268052_Chip-Seq_Bcells_Human	0.99156215
86	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98152887
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.97088230
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96212900
89	P68_20966046_ChIP-Seq_HELA_Human	0.95041565
90	BCOR_27268052_Chip-Seq_Bcells_Human	0.93842780
91	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92419640
92	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.92397326
93	P53_21459846_ChIP-Seq_SAOS-2_Human	0.92384419
94	CTCF_27219007_Chip-Seq_Bcells_Human	0.91893537
95	EWS_26573619_Chip-Seq_HEK293_Human	0.91880209
96	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.88874160
97	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.88565083
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.88264549
99	GATA3_26560356_Chip-Seq_TH2_Human	0.87440821
100	FUS_26573619_Chip-Seq_HEK293_Human	0.86947348

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003646_muscle_fatigue	4.43625053
2	MP0006292_abnormal_olfactory_placode	4.31014406
3	MP0009379_abnormal_foot_pigmentation	3.51484524
4	MP0000569_abnormal_digit_pigmentation	2.89732033
5	MP0003787_abnormal_imprinting	2.67329088
6	MP0002163_abnormal_gland_morphology	2.41630475
7	MP0001986_abnormal_taste_sensitivity	2.40484036
8	MP0003878_abnormal_ear_physiology	2.37162268
9	MP0005377_hearing/vestibular/ear_phenot	2.37162268
10	MP0004142_abnormal_muscle_tone	2.22942813
11	MP0005423_abnormal_somatic_nervous	2.02931773
12	MP0004885_abnormal_endolymph	1.96552228
13	MP0008877_abnormal_DNA_methylation	1.96018980
14	MP0005551_abnormal_eye_electrophysiolog	1.93168103
15	MP0006072_abnormal_retinal_apoptosis	1.91421545
16	MP0008789_abnormal_olfactory_epithelium	1.91027277
17	MP0005174_abnormal_tail_pigmentation	1.85081671
18	MP0002102_abnormal_ear_morphology	1.80397868
19	MP0002876_abnormal_thyroid_physiology	1.76713874
20	MP0004145_abnormal_muscle_electrophysio	1.74950915
21	MP0009046_muscle_twitch	1.73785185
22	MP0002653_abnormal_ependyma_morphology	1.66761539
23	MP0006276_abnormal_autonomic_nervous	1.66113280
24	MP0001984_abnormal_olfaction	1.61302726
25	MP0005499_abnormal_olfactory_system	1.61086123
26	MP0005394_taste/olfaction_phenotype	1.61086123
27	MP0003122_maternal_imprinting	1.59668679
28	MP0001919_abnormal_reproductive_system	1.58780389
29	MP0004742_abnormal_vestibular_system	1.50840839
30	MP0004133_heterotaxia	1.43536219
31	MP0001293_anophthalmia	1.42576450
32	MP0001968_abnormal_touch/_nociception	1.41546380
33	MP0002938_white_spotting	1.41030420
34	MP0000015_abnormal_ear_pigmentation	1.38824083
35	MP0003123_paternal_imprinting	1.36468228
36	MP0001529_abnormal_vocalization	1.33404681
37	MP0002095_abnormal_skin_pigmentation	1.32703607
38	MP0003879_abnormal_hair_cell	1.32248426
39	MP0001324_abnormal_eye_pigmentation	1.31992751
40	MP0002272_abnormal_nervous_system	1.28745073
41	MP0000778_abnormal_nervous_system	1.27499553
42	MP0005389_reproductive_system_phenotype	1.25949563
43	MP0000631_abnormal_neuroendocrine_gland	1.25322591
44	MP0002234_abnormal_pharynx_morphology	1.24559513
45	MP0008875_abnormal_xenobiotic_pharmacok	1.24259605
46	MP0003567_abnormal_fetal_cardiomyocyte	1.23353073
47	MP0001970_abnormal_pain_threshold	1.22631755
48	MP0001485_abnormal_pinna_reflex	1.21629046
49	MP0003121_genomic_imprinting	1.21391641
50	MP0002638_abnormal_pupillary_reflex	1.21042080
51	MP0009745_abnormal_behavioral_response	1.20949550
52	MP0002736_abnormal_nociception_after	1.16387472
53	MP0000372_irregular_coat_pigmentation	1.15507802
54	MP0005075_abnormal_melanosome_morpholog	1.14936736
55	MP0003693_abnormal_embryo_hatching	1.13980842
56	MP0000049_abnormal_middle_ear	1.07895860
57	MP0005195_abnormal_posterior_eye	1.07852406
58	MP0008872_abnormal_physiological_respon	1.06536544
59	MP0005379_endocrine/exocrine_gland_phen	1.05234326
60	MP0002734_abnormal_mechanical_nocicepti	1.05008923
61	MP0003119_abnormal_digestive_system	1.04116669
62	MP0002557_abnormal_social/conspecific_i	1.02200130
63	MP0004147_increased_porphyrin_level	0.99409213
64	MP0003806_abnormal_nucleotide_metabolis	0.97668678
65	MP0003635_abnormal_synaptic_transmissio	0.96751332
66	MP0003937_abnormal_limbs/digits/tail_de	0.96488043
67	MP0003136_yellow_coat_color	0.95976549
68	MP0002822_catalepsy	0.95929612
69	MP0003186_abnormal_redox_activity	0.95471366
70	MP0002063_abnormal_learning/memory/cond	0.95289377
71	MP0002572_abnormal_emotion/affect_behav	0.94376239
72	MP0005253_abnormal_eye_physiology	0.94334912
73	MP0002752_abnormal_somatic_nervous	0.93176224
74	MP0002733_abnormal_thermal_nociception	0.92227705
75	MP0001905_abnormal_dopamine_level	0.91512953
76	MP0006036_abnormal_mitochondrial_physio	0.89838498
77	MP0000955_abnormal_spinal_cord	0.88842355
78	MP0003890_abnormal_embryonic-extraembry	0.86793420
79	MP0002067_abnormal_sensory_capabilities	0.82539104
80	MP0005391_vision/eye_phenotype	0.82184904
81	MP0000026_abnormal_inner_ear	0.81880188
82	MP0001963_abnormal_hearing_physiology	0.81520853
83	MP0003880_abnormal_central_pattern	0.80935481
84	MP0003755_abnormal_palate_morphology	0.80236793
85	MP0003436_decreased_susceptibility_to	0.80093091
86	MP0005671_abnormal_response_to	0.79494854
87	MP0002233_abnormal_nose_morphology	0.79335023
88	MP0003938_abnormal_ear_development	0.77351447
89	MP0005084_abnormal_gallbladder_morpholo	0.75517083
90	MP0002160_abnormal_reproductive_system	0.75155528
91	MP0003936_abnormal_reproductive_system	0.74706288
92	MP0005646_abnormal_pituitary_gland	0.74239800
93	MP0005645_abnormal_hypothalamus_physiol	0.74222431
94	MP0004381_abnormal_hair_follicle	0.73502355
95	MP0009764_decreased_sensitivity_to	0.73272396
96	MP0002837_dystrophic_cardiac_calcinosis	0.72097792
97	MP0001727_abnormal_embryo_implantation	0.71676469
98	MP0003195_calcinosis	0.71559458
99	MP0002882_abnormal_neuron_morphology	0.71416297
100	MP0001501_abnormal_sleep_pattern	0.71060352

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Molar tooth sign on MRI (HP:0002419)	4.77866289
2	Abnormality of midbrain morphology (HP:0002418)	4.77866289
3	Reticulocytopenia (HP:0001896)	4.28804986
4	3-Methylglutaconic aciduria (HP:0003535)	4.00460485
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.94258891
6	Absent/shortened dynein arms (HP:0200106)	3.94258891
7	Acute necrotizing encephalopathy (HP:0006965)	3.90875058
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.74850104
9	Pancreatic fibrosis (HP:0100732)	3.61938744
10	Microvesicular hepatic steatosis (HP:0001414)	3.56131325
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.47267979
12	Pancreatic cysts (HP:0001737)	3.47187024
13	Abnormal drinking behavior (HP:0030082)	3.46514559
14	Polydipsia (HP:0001959)	3.46514559
15	Acute encephalopathy (HP:0006846)	3.34038703
16	Mitochondrial inheritance (HP:0001427)	3.24493227
17	Nephronophthisis (HP:0000090)	3.23485383
18	Increased CSF lactate (HP:0002490)	3.20514019
19	Congenital stationary night blindness (HP:0007642)	3.19798124
20	True hermaphroditism (HP:0010459)	3.17469771
21	Progressive macrocephaly (HP:0004481)	3.05745683
22	Type II lissencephaly (HP:0007260)	2.90701733
23	Abnormal respiratory motile cilium morphology (HP:0005938)	2.90549723
24	Abnormal respiratory epithelium morphology (HP:0012253)	2.90549723
25	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.84811824
26	Decreased central vision (HP:0007663)	2.82494767
27	Pendular nystagmus (HP:0012043)	2.80553742
28	Medial flaring of the eyebrow (HP:0010747)	2.76409771
29	Bile duct proliferation (HP:0001408)	2.76187729
30	Abnormal biliary tract physiology (HP:0012439)	2.76187729
31	Abnormal rod and cone electroretinograms (HP:0008323)	2.74380623
32	Cystic liver disease (HP:0006706)	2.73876304
33	Abnormality of cells of the erythroid lineage (HP:0012130)	2.73546706
34	Increased corneal curvature (HP:0100692)	2.71628695
35	Keratoconus (HP:0000563)	2.71628695
36	Increased intramyocellular lipid droplets (HP:0012240)	2.68730985
37	Abnormal ciliary motility (HP:0012262)	2.65172424
38	Lissencephaly (HP:0001339)	2.57461393
39	Macrocytic anemia (HP:0001972)	2.56312226
40	Increased hepatocellular lipid droplets (HP:0006565)	2.55930320
41	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.53762584
42	Optic disc pallor (HP:0000543)	2.51270915
43	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.50411536
44	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.50411536
45	Severe visual impairment (HP:0001141)	2.49773124
46	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.42425363
47	Testicular atrophy (HP:0000029)	2.42175460
48	Impulsivity (HP:0100710)	2.39799107
49	Abnormal respiratory motile cilium physiology (HP:0012261)	2.37041071
50	Ragged-red muscle fibers (HP:0003200)	2.35420466
51	Polyuria (HP:0000103)	2.35036873
52	Renovascular hypertension (HP:0100817)	2.34732835
53	Lipid accumulation in hepatocytes (HP:0006561)	2.34016949
54	Anencephaly (HP:0002323)	2.32337496
55	Cerebral edema (HP:0002181)	2.32103725
56	Abnormality of the renal medulla (HP:0100957)	2.31285080
57	Tubular atrophy (HP:0000092)	2.29890875
58	Tubulointerstitial nephritis (HP:0001970)	2.19765390
59	Increased serum lactate (HP:0002151)	2.19418373
60	Increased muscle lipid content (HP:0009058)	2.19160388
61	Postaxial foot polydactyly (HP:0001830)	2.17114570
62	Increased serum pyruvate (HP:0003542)	2.15160410
63	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.14229904
64	Agitation (HP:0000713)	2.12367304
65	Chronic hepatic failure (HP:0100626)	2.11529848
66	Myokymia (HP:0002411)	2.11321969
67	Pachygyria (HP:0001302)	2.10424259
68	Congenital hepatic fibrosis (HP:0002612)	2.10120613
69	Abnormality of the renal cortex (HP:0011035)	2.10033614
70	Renal Fanconi syndrome (HP:0001994)	2.08862761
71	Hepatocellular necrosis (HP:0001404)	2.07599806
72	Gait imbalance (HP:0002141)	2.05851596
73	Exercise intolerance (HP:0003546)	2.04466488
74	Sclerocornea (HP:0000647)	2.01834248
75	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.01441856
76	Congenital primary aphakia (HP:0007707)	2.00899026
77	Absent thumb (HP:0009777)	2.00751351
78	Nephrogenic diabetes insipidus (HP:0009806)	2.00087799
79	Anomalous pulmonary venous return (HP:0010772)	1.98317949
80	Rib fusion (HP:0000902)	1.98069173
81	Abnormal number of erythroid precursors (HP:0012131)	1.97762913
82	Asplenia (HP:0001746)	1.96426636
83	Pallor (HP:0000980)	1.95448822
84	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.92129989
85	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.92129989
86	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92054242
87	Tubulointerstitial abnormality (HP:0001969)	1.87971248
88	Supernumerary spleens (HP:0009799)	1.87455942
89	Inability to walk (HP:0002540)	1.87114060
90	Depressed nasal ridge (HP:0000457)	1.86843783
91	Abnormal urine output (HP:0012590)	1.85128577
92	Hepatic necrosis (HP:0002605)	1.82296570
93	Sensory axonal neuropathy (HP:0003390)	1.82061758
94	Lactic acidosis (HP:0003128)	1.81673936
95	Rhinitis (HP:0012384)	1.80388847
96	Focal motor seizures (HP:0011153)	1.79739544
97	Hyperglycinemia (HP:0002154)	1.79732726
98	Abnormality of glycolysis (HP:0004366)	1.78585956
99	Attenuation of retinal blood vessels (HP:0007843)	1.78230932
100	Broad-based gait (HP:0002136)	1.70035323

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	4.60091115
2	TXK	3.64481873
3	TLK1	3.04247603
4	WNK4	2.82179305
5	ADRBK2	2.75500880
6	CAMKK2	2.72207617
7	CDK8	2.66328885
8	ZAK	2.51962937
9	MAP3K11	2.43646431
10	MAP4K2	2.17777966
11	BRSK1	2.04844054
12	CDC42BPA	2.01819847
13	CASK	1.86868836
14	GRK1	1.70586085
15	PHKG1	1.65738954
16	PHKG2	1.65738954
17	DYRK2	1.64233502
18	SRPK1	1.61067664
19	FRK	1.59022538
20	CAMK1D	1.58648537
21	BCKDK	1.52595325
22	STK39	1.48740069
23	TIE1	1.46551690
24	NME2	1.38350794
25	MAPK13	1.33937783
26	MAP4K1	1.32745721
27	MST4	1.31717566
28	VRK2	1.27034191
29	EPHB2	1.18868916
30	CLK1	1.18659729
31	CAMKK1	1.17118331
32	DAPK2	1.16837528
33	AURKA	1.14178335
34	CDK19	1.09356066
35	WNK3	1.07183361
36	PDK2	1.02700820
37	CAMK1	1.02265640
38	CAMK1G	0.99881971
39	LRRK2	0.97976098
40	NTRK2	0.93480560
41	CAMK4	0.91319167
42	BRSK2	0.85250166
43	ADRBK1	0.83417562
44	BLK	0.82423122
45	CSNK1G2	0.79659463
46	PIM2	0.75630184
47	PINK1	0.75564556
48	DYRK1B	0.75328404
49	OXSR1	0.74498127
50	PRKCQ	0.69014311
51	CDC7	0.67627922
52	TTK	0.65733239
53	MARK1	0.63012122
54	TAOK3	0.61821331
55	GRK6	0.61392780
56	TAF1	0.61245327
57	PLK1	0.60687307
58	ATR	0.56271813
59	INSRR	0.52861378
60	DAPK3	0.51393330
61	MAPK11	0.51274850
62	STK38L	0.50875989
63	CSNK1A1L	0.50664733
64	MAPKAPK3	0.49529807
65	AURKB	0.49362732
66	BMPR1B	0.48799939
67	AKT2	0.47786376
68	KDR	0.46923919
69	MAPKAPK2	0.46869024
70	CSNK1G3	0.46402651
71	RPS6KA6	0.46284551
72	CSNK1E	0.46090927
73	SGK494	0.45758899
74	SGK223	0.45758899
75	CSNK2A2	0.45035407
76	ERBB2	0.43335909
77	TSSK6	0.42886362
78	TEC	0.42477517
79	ITK	0.41992693
80	IKBKB	0.41903811
81	PRKACA	0.41372291
82	CAMK2A	0.41189324
83	MAP2K7	0.40722515
84	SYK	0.40665056
85	KIT	0.40083278
86	IKBKE	0.39747400
87	BRAF	0.39725035
88	PIK3CA	0.38131106
89	MELK	0.37523884
90	PRKCG	0.36995103
91	GRK5	0.36673004
92	VRK1	0.36295499
93	MUSK	0.36061389
94	PLK3	0.35531655
95	EPHA4	0.35289800
96	CSNK2A1	0.34217679
97	PRKCI	0.33290038
98	TGFBR1	0.33148728
99	CHEK2	0.31372023
100	MAP2K2	0.31153195

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.11789013
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.90492755
3	Parkinsons disease_Homo sapiens_hsa05012	3.38963324
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.80730088
5	RNA polymerase_Homo sapiens_hsa03020	2.58922887
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.48266936
7	RNA degradation_Homo sapiens_hsa03018	2.43115609
8	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.38389554
9	Huntingtons disease_Homo sapiens_hsa05016	2.36221718
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.35410085
11	Sulfur relay system_Homo sapiens_hsa04122	2.31463393
12	Protein export_Homo sapiens_hsa03060	2.30577565
13	Alzheimers disease_Homo sapiens_hsa05010	2.20115367
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.09779245
15	Phototransduction_Homo sapiens_hsa04744	1.94802531
16	Basal transcription factors_Homo sapiens_hsa03022	1.81701732
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.70868930
18	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.64924685
19	Proteasome_Homo sapiens_hsa03050	1.58886528
20	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.56207967
21	Homologous recombination_Homo sapiens_hsa03440	1.49743257
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48196344
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41722431
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.39319686
25	One carbon pool by folate_Homo sapiens_hsa00670	1.38896855
26	Ether lipid metabolism_Homo sapiens_hsa00565	1.36985391
27	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.36843866
28	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.36481813
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31331862
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.21099954
31	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.20201081
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17180415
33	Steroid biosynthesis_Homo sapiens_hsa00100	1.11559507
34	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11235407
35	Nicotine addiction_Homo sapiens_hsa05033	1.08022866
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.07399829
37	Sulfur metabolism_Homo sapiens_hsa00920	1.06113428
38	Caffeine metabolism_Homo sapiens_hsa00232	1.05919006
39	Butanoate metabolism_Homo sapiens_hsa00650	1.04267896
40	Propanoate metabolism_Homo sapiens_hsa00640	1.03057899
41	Fat digestion and absorption_Homo sapiens_hsa04975	1.02321074
42	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.01259333
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98812075
44	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98080410
45	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95142229
46	Graft-versus-host disease_Homo sapiens_hsa05332	0.94288366
47	Purine metabolism_Homo sapiens_hsa00230	0.90647183
48	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88279152
49	Metabolic pathways_Homo sapiens_hsa01100	0.84365850
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.77877348
51	Olfactory transduction_Homo sapiens_hsa04740	0.77721835
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.77627598
53	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.77346355
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.76590875
55	Allograft rejection_Homo sapiens_hsa05330	0.75796942
56	Peroxisome_Homo sapiens_hsa04146	0.75585261
57	Asthma_Homo sapiens_hsa05310	0.75568815
58	Primary immunodeficiency_Homo sapiens_hsa05340	0.74926893
59	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73458831
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.70890421
61	Spliceosome_Homo sapiens_hsa03040	0.68983036
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.67862664
63	Morphine addiction_Homo sapiens_hsa05032	0.66918632
64	Glutathione metabolism_Homo sapiens_hsa00480	0.64364171
65	Nitrogen metabolism_Homo sapiens_hsa00910	0.64344442
66	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.63665814
67	Taste transduction_Homo sapiens_hsa04742	0.63520358
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.62761115
69	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61828915
70	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.57721900
71	Histidine metabolism_Homo sapiens_hsa00340	0.57131897
72	Basal cell carcinoma_Homo sapiens_hsa05217	0.56997605
73	Pyruvate metabolism_Homo sapiens_hsa00620	0.55226291
74	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.54690041
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.52120140
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.49965307
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49475502
78	Non-homologous end-joining_Homo sapiens_hsa03450	0.47179816
79	Retinol metabolism_Homo sapiens_hsa00830	0.47030194
80	RNA transport_Homo sapiens_hsa03013	0.43015022
81	Fatty acid degradation_Homo sapiens_hsa00071	0.42418031
82	Notch signaling pathway_Homo sapiens_hsa04330	0.42175600
83	Antigen processing and presentation_Homo sapiens_hsa04612	0.40900074
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.37465268
85	Serotonergic synapse_Homo sapiens_hsa04726	0.32855749
86	Axon guidance_Homo sapiens_hsa04360	0.30942771
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28495913
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.27601223
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.26797698
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26794277
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.26093216
92	Insulin secretion_Homo sapiens_hsa04911	0.25763641
93	GABAergic synapse_Homo sapiens_hsa04727	0.24632118
94	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.24629778
95	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24608567
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.23848452
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.22436051
98	p53 signaling pathway_Homo sapiens_hsa04115	0.22302940
99	Lysine degradation_Homo sapiens_hsa00310	0.22188087
100	Glutamatergic synapse_Homo sapiens_hsa04724	0.19420380

RPL36P16

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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