RPL36P18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of helicase activity (GO:0051095)6.87030962
2pyrimidine dimer repair (GO:0006290)6.02543891
3regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.94042760
4regulation of mitotic spindle checkpoint (GO:1903504)4.94042760
5single strand break repair (GO:0000012)4.83567631
6response to pheromone (GO:0019236)4.82916122
7neural tube formation (GO:0001841)4.66299911
8centriole replication (GO:0007099)4.59962544
9limb bud formation (GO:0060174)4.53372652
10histone H2A acetylation (GO:0043968)4.47193698
11cell wall macromolecule catabolic process (GO:0016998)4.38349149
12DNA strand renaturation (GO:0000733)4.32998685
13regulation of timing of cell differentiation (GO:0048505)4.26742920
14replication fork processing (GO:0031297)4.19133116
15positive regulation of mitochondrial fission (GO:0090141)4.12497101
16epithelial cilium movement (GO:0003351)4.08882766
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.03359676
18regulation of development, heterochronic (GO:0040034)3.72776940
19cell wall macromolecule metabolic process (GO:0044036)3.69230400
20glial cell proliferation (GO:0014009)3.51851736
21epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.50272921
22protein K6-linked ubiquitination (GO:0085020)3.49938498
23morphogenesis of an endothelium (GO:0003159)3.42799525
24endothelial tube morphogenesis (GO:0061154)3.42799525
25fucose catabolic process (GO:0019317)3.39465192
26L-fucose metabolic process (GO:0042354)3.39465192
27L-fucose catabolic process (GO:0042355)3.39465192
28adaptation of signaling pathway (GO:0023058)3.38663433
29somite development (GO:0061053)3.24254482
30protein polyglutamylation (GO:0018095)3.23632890
31negative regulation of cell aging (GO:0090344)3.23372248
32maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22883093
33regulation of chromatin silencing (GO:0031935)3.21904210
34cilium movement (GO:0003341)3.21772940
35regulation of MHC class II biosynthetic process (GO:0045346)3.19674248
36regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.16489104
37nucleoside transmembrane transport (GO:1901642)3.14458571
38cilium morphogenesis (GO:0060271)3.13192660
39mitotic cell cycle arrest (GO:0071850)3.13084487
40serine family amino acid catabolic process (GO:0009071)3.12587149
41kidney morphogenesis (GO:0060993)3.12419186
42negative regulation of mast cell activation (GO:0033004)3.10672276
43mismatch repair (GO:0006298)3.04879295
44mitochondrial RNA metabolic process (GO:0000959)3.02208023
45cardiac left ventricle morphogenesis (GO:0003214)2.98542765
46metaphase plate congression (GO:0051310)2.97656054
47somatic diversification of immune receptors via somatic mutation (GO:0002566)2.97321587
48somatic hypermutation of immunoglobulin genes (GO:0016446)2.97321587
49mitotic metaphase plate congression (GO:0007080)2.96106311
50intraciliary transport (GO:0042073)2.93595670
51resolution of meiotic recombination intermediates (GO:0000712)2.93150922
52cornea development in camera-type eye (GO:0061303)2.92449450
53cullin deneddylation (GO:0010388)2.92270783
54DNA double-strand break processing (GO:0000729)2.91750978
55regulation of nuclear cell cycle DNA replication (GO:0033262)2.89213943
56regulation of cellular senescence (GO:2000772)2.88230990
57regulation of mitochondrial fission (GO:0090140)2.88229085
58ovulation from ovarian follicle (GO:0001542)2.87949578
59reciprocal DNA recombination (GO:0035825)2.87572207
60reciprocal meiotic recombination (GO:0007131)2.87572207
61negative regulation of TOR signaling (GO:0032007)2.86704384
62centriole assembly (GO:0098534)2.86629407
63regulation of telomere maintenance (GO:0032204)2.83877566
64chaperone-mediated protein transport (GO:0072321)2.78342853
65epithelial cell fate commitment (GO:0072148)2.77787885
66protein deneddylation (GO:0000338)2.76140963
67positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.74409353
68positive regulation of mitotic sister chromatid separation (GO:1901970)2.74409353
69positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.74409353
70positive regulation of oligodendrocyte differentiation (GO:0048714)2.73856463
71nucleotide-excision repair, DNA gap filling (GO:0006297)2.73151586
72negative regulation of epidermal cell differentiation (GO:0045605)2.71579077
73negative regulation of alpha-beta T cell differentiation (GO:0046639)2.71448264
74water-soluble vitamin biosynthetic process (GO:0042364)2.71207780
75inositol phosphate catabolic process (GO:0071545)2.69075919
76monoubiquitinated protein deubiquitination (GO:0035520)2.67008367
77recombinational repair (GO:0000725)2.66870589
78regulation of smooth muscle cell apoptotic process (GO:0034391)2.64506307
79double-strand break repair via homologous recombination (GO:0000724)2.63770297
80prenylation (GO:0097354)2.63767558
81protein prenylation (GO:0018342)2.63767558
82embryonic epithelial tube formation (GO:0001838)2.63760374
83amino-acid betaine metabolic process (GO:0006577)2.63204513
84cilium organization (GO:0044782)2.62803844
85regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.62081757
86DNA replication-dependent nucleosome organization (GO:0034723)2.61591713
87DNA replication-dependent nucleosome assembly (GO:0006335)2.61591713
88mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.61284372
89mitochondrial respiratory chain complex I assembly (GO:0032981)2.61284372
90NADH dehydrogenase complex assembly (GO:0010257)2.61284372
91C-terminal protein amino acid modification (GO:0018410)2.61182086
92DNA synthesis involved in DNA repair (GO:0000731)2.60713462
93spliceosomal complex assembly (GO:0000245)2.59007774
94positive regulation of DNA repair (GO:0045739)2.58802074
95cilium assembly (GO:0042384)2.58283328
96kinetochore assembly (GO:0051382)2.57147908
97regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.56928116
98detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.56815050
99peroxisome fission (GO:0016559)2.56467905
100regulation of spindle checkpoint (GO:0090231)2.54587234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.91111251
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.87732446
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.72311556
4ZNF274_21170338_ChIP-Seq_K562_Hela3.58507835
5GBX2_23144817_ChIP-Seq_PC3_Human3.30675307
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.24782927
7TAF15_26573619_Chip-Seq_HEK293_Human2.93110295
8VDR_22108803_ChIP-Seq_LS180_Human2.88356841
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.76039294
10IGF1R_20145208_ChIP-Seq_DFB_Human2.67052801
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.66487847
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.65562921
13EZH2_22144423_ChIP-Seq_EOC_Human2.65253244
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.57886379
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.28611261
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24649759
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.22366382
18P300_19829295_ChIP-Seq_ESCs_Human2.19481591
19FUS_26573619_Chip-Seq_HEK293_Human2.18356354
20EWS_26573619_Chip-Seq_HEK293_Human2.18167305
21POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18046052
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.17909619
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17565723
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03726424
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.02127080
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.98354985
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.93474414
28ELK1_19687146_ChIP-ChIP_HELA_Human1.86359219
29PCGF2_27294783_Chip-Seq_ESCs_Mouse1.73463876
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59153433
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55917394
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53835109
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.51527203
34SOX2_19829295_ChIP-Seq_ESCs_Human1.48892292
35NANOG_19829295_ChIP-Seq_ESCs_Human1.48892292
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48599708
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.45663965
38BCAT_22108803_ChIP-Seq_LS180_Human1.44868310
39SMAD4_21799915_ChIP-Seq_A2780_Human1.44235567
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41467571
41IRF1_19129219_ChIP-ChIP_H3396_Human1.36566718
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.35606971
43SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34472392
44TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33731280
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33731280
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31896388
47TP53_22573176_ChIP-Seq_HFKS_Human1.30678061
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30641845
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28054694
50MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.26849584
51KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26401278
52ER_23166858_ChIP-Seq_MCF-7_Human1.25734938
53NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25683533
54TCF4_23295773_ChIP-Seq_U87_Human1.21671213
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20770560
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19987390
57RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18678271
58VDR_23849224_ChIP-Seq_CD4+_Human1.18301550
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18136801
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17800879
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.15506734
62STAT3_23295773_ChIP-Seq_U87_Human1.15420630
63PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15356947
64CREB1_15753290_ChIP-ChIP_HEK293T_Human1.15179178
65CBP_20019798_ChIP-Seq_JUKART_Human1.13794971
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13794971
67FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13729539
68FOXA1_25329375_ChIP-Seq_VCAP_Human1.13729539
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.12274491
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.11698563
71AR_21572438_ChIP-Seq_LNCaP_Human1.11036192
72RUNX2_22187159_ChIP-Seq_PCA_Human1.10352732
73AR_25329375_ChIP-Seq_VCAP_Human1.09987979
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.09191079
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08750345
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.08653795
77HTT_18923047_ChIP-ChIP_STHdh_Human1.08446156
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.06127513
79FOXP3_21729870_ChIP-Seq_TREG_Human1.05500106
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04589363
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01872305
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01360169
83NANOG_18555785_Chip-Seq_ESCs_Mouse1.00727455
84TCF4_22108803_ChIP-Seq_LS180_Human0.99806203
85CBX2_27304074_Chip-Seq_ESCs_Mouse0.99474305
86SRF_21415370_ChIP-Seq_HL-1_Mouse0.97708320
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.97688240
88SMAD3_21741376_ChIP-Seq_EPCs_Human0.97476720
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97069245
90POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96776613
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96428628
92MYC_18940864_ChIP-ChIP_HL60_Human0.96172093
93CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.95493513
94CDX2_22108803_ChIP-Seq_LS180_Human0.93039489
95AR_20517297_ChIP-Seq_VCAP_Human0.92735390
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.92169496
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91273809
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89748580
99RNF2_27304074_Chip-Seq_NSC_Mouse0.88142667
100SOX2_21211035_ChIP-Seq_LN229_Gbm0.87120940

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.58999505
2MP0008877_abnormal_DNA_methylation4.67841880
3MP0002837_dystrophic_cardiac_calcinosis4.52761724
4MP0000569_abnormal_digit_pigmentation3.47977454
5MP0002102_abnormal_ear_morphology3.27850700
6MP0008058_abnormal_DNA_repair2.65433265
7MP0003787_abnormal_imprinting2.51204697
8MP0000566_synostosis2.44615072
9MP0006072_abnormal_retinal_apoptosis2.32217659
10MP0006292_abnormal_olfactory_placode2.16791124
11MP0002938_white_spotting2.16583390
12MP0008872_abnormal_physiological_respon2.16149876
13MP0001986_abnormal_taste_sensitivity2.03928811
14MP0003880_abnormal_central_pattern1.95323372
15MP0009053_abnormal_anal_canal1.93480482
16MP0009379_abnormal_foot_pigmentation1.92360043
17MP0003718_maternal_effect1.89367815
18MP0005551_abnormal_eye_electrophysiolog1.87024649
19MP0010094_abnormal_chromosome_stability1.86444437
20MP0004885_abnormal_endolymph1.84126211
21MP0002234_abnormal_pharynx_morphology1.82411961
22MP0005253_abnormal_eye_physiology1.79476846
23MP0008775_abnormal_heart_ventricle1.77876376
24MP0002736_abnormal_nociception_after1.52789159
25MP0005174_abnormal_tail_pigmentation1.50806054
26MP0003943_abnormal_hepatobiliary_system1.49751637
27MP0000383_abnormal_hair_follicle1.48823712
28MP0001293_anophthalmia1.47431564
29MP0004215_abnormal_myocardial_fiber1.44255317
30MP0003567_abnormal_fetal_cardiomyocyte1.44100658
31MP0001486_abnormal_startle_reflex1.40045143
32MP0008875_abnormal_xenobiotic_pharmacok1.39649388
33MP0000778_abnormal_nervous_system1.35360824
34MP0008789_abnormal_olfactory_epithelium1.33378506
35MP0004133_heterotaxia1.32854821
36MP0003755_abnormal_palate_morphology1.30840653
37MP0009046_muscle_twitch1.30307691
38MP0000049_abnormal_middle_ear1.26423262
39MP0002751_abnormal_autonomic_nervous1.26313619
40MP0001485_abnormal_pinna_reflex1.25721397
41MP0003941_abnormal_skin_development1.23071330
42MP0005220_abnormal_exocrine_pancreas1.21021806
43MP0003937_abnormal_limbs/digits/tail_de1.20619010
44MP0000631_abnormal_neuroendocrine_gland1.18166874
45MP0002638_abnormal_pupillary_reflex1.17798182
46MP0004147_increased_porphyrin_level1.16679571
47MP0002735_abnormal_chemical_nociception1.15393861
48MP0006036_abnormal_mitochondrial_physio1.14526216
49MP0001968_abnormal_touch/_nociception1.11924600
50MP0003111_abnormal_nucleus_morphology1.10470565
51MP0005391_vision/eye_phenotype1.08035445
52MP0005395_other_phenotype1.07766297
53MP0000372_irregular_coat_pigmentation1.07411431
54MP0000427_abnormal_hair_cycle1.06836788
55MP0002653_abnormal_ependyma_morphology1.06697877
56MP0004084_abnormal_cardiac_muscle1.02439428
57MP0010678_abnormal_skin_adnexa1.01175285
58MP0005195_abnormal_posterior_eye0.99530764
59MP0003890_abnormal_embryonic-extraembry0.98507382
60MP0006276_abnormal_autonomic_nervous0.97878527
61MP0000647_abnormal_sebaceous_gland0.96753136
62MP0003693_abnormal_embryo_hatching0.94470312
63MP0003121_genomic_imprinting0.89668791
64MP0001727_abnormal_embryo_implantation0.88688243
65MP0002272_abnormal_nervous_system0.87260390
66MP0002572_abnormal_emotion/affect_behav0.84727462
67MP0005266_abnormal_metabolism0.83838538
68MP0002098_abnormal_vibrissa_morphology0.83823923
69MP0006035_abnormal_mitochondrial_morpho0.83328647
70MP0002095_abnormal_skin_pigmentation0.82082709
71MP0000516_abnormal_urinary_system0.81680869
72MP0005367_renal/urinary_system_phenotyp0.81680869
73MP0002282_abnormal_trachea_morphology0.81363783
74MP0004957_abnormal_blastocyst_morpholog0.80619334
75MP0005248_abnormal_Harderian_gland0.77914321
76MP0001348_abnormal_lacrimal_gland0.77526860
77MP0001286_abnormal_eye_development0.77103287
78MP0005647_abnormal_sex_gland0.76431361
79MP0001963_abnormal_hearing_physiology0.76416338
80MP0001177_atelectasis0.75949728
81MP0003861_abnormal_nervous_system0.75422284
82MP0005499_abnormal_olfactory_system0.73578844
83MP0005394_taste/olfaction_phenotype0.73578844
84MP0002697_abnormal_eye_size0.73196743
85MP0000371_diluted_coat_color0.73056989
86MP0002909_abnormal_adrenal_gland0.71360548
87MP0003283_abnormal_digestive_organ0.69183009
88MP0009745_abnormal_behavioral_response0.68842817
89MP0002557_abnormal_social/conspecific_i0.68820843
90MP0001849_ear_inflammation0.68633171
91MP0004233_abnormal_muscle_weight0.68310141
92MP0002210_abnormal_sex_determination0.68013520
93MP0002752_abnormal_somatic_nervous0.66359411
94MP0002168_other_aberrant_phenotype0.65226535
95MP0001119_abnormal_female_reproductive0.65065863
96MP0003315_abnormal_perineum_morphology0.65057860
97MP0002064_seizures0.64892407
98MP0001929_abnormal_gametogenesis0.63623139
99MP0005379_endocrine/exocrine_gland_phen0.63490683
100MP0003936_abnormal_reproductive_system0.63301710

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.83873677
2Colon cancer (HP:0003003)4.73586816
3Molar tooth sign on MRI (HP:0002419)4.50456899
4Abnormality of midbrain morphology (HP:0002418)4.50456899
5True hermaphroditism (HP:0010459)4.25387378
6Pancreatic fibrosis (HP:0100732)3.98811093
7Cystic liver disease (HP:0006706)3.53731014
8Neoplasm of the adrenal cortex (HP:0100641)3.49708332
9Focal motor seizures (HP:0011153)3.26294402
10Abnormal hair whorl (HP:0010721)3.24168997
11Adactyly (HP:0009776)3.23301567
12Hypoproteinemia (HP:0003075)3.20716588
13Rectal fistula (HP:0100590)3.17505431
14Rectovaginal fistula (HP:0000143)3.17505431
15Nephronophthisis (HP:0000090)3.17371193
16Intestinal atresia (HP:0011100)3.13991628
17Skull defect (HP:0001362)3.09023901
18Occipital encephalocele (HP:0002085)2.97278939
19Ependymoma (HP:0002888)2.96395242
20Vitreoretinal degeneration (HP:0000655)2.88288997
21Abnormality of the labia minora (HP:0012880)2.80076430
22Chronic hepatic failure (HP:0100626)2.79326320
23Type II lissencephaly (HP:0007260)2.72220460
24Aplasia/Hypoplasia of the tongue (HP:0010295)2.69744379
25Vaginal fistula (HP:0004320)2.65767936
26Fair hair (HP:0002286)2.64182197
27Hyperglycinuria (HP:0003108)2.60685277
28Prostate neoplasm (HP:0100787)2.59464617
29Abnormality of the renal medulla (HP:0100957)2.54026441
30Facial hemangioma (HP:0000329)2.53558483
31Intestinal fistula (HP:0100819)2.51382634
32Aplasia cutis congenita (HP:0001057)2.47707663
33Hypoplastic nipples (HP:0002557)2.44269769
34Bifid tongue (HP:0010297)2.44138323
35Congenital hepatic fibrosis (HP:0002612)2.42950451
36Glioma (HP:0009733)2.30683481
37Hyperglycinemia (HP:0002154)2.30630458
38Clitoromegaly (HP:0000057)2.30243531
39Dandy-Walker malformation (HP:0001305)2.25200175
40Abnormality of the pons (HP:0007361)2.24974090
41Horizontal nystagmus (HP:0000666)2.24835167
42Preaxial hand polydactyly (HP:0001177)2.22244250
43Male pseudohermaphroditism (HP:0000037)2.20663478
44Chorioretinal coloboma (HP:0000567)2.20158322
45Abnormality of the astrocytes (HP:0100707)2.16276489
46Astrocytoma (HP:0009592)2.16276489
47Sclerocornea (HP:0000647)2.15884301
48Abnormality of serine family amino acid metabolism (HP:0010894)2.15281821
49Abnormality of glycine metabolism (HP:0010895)2.15281821
50Oculomotor apraxia (HP:0000657)2.11944205
51Bilateral microphthalmos (HP:0007633)2.11698332
52Pendular nystagmus (HP:0012043)2.10837031
53Septate vagina (HP:0001153)2.10614368
54Hypoplasia of the pons (HP:0012110)2.10296981
55Widely spaced teeth (HP:0000687)2.09991029
56Renal hypoplasia (HP:0000089)2.09856550
57Postaxial foot polydactyly (HP:0001830)2.09552354
58Abnormal lung lobation (HP:0002101)2.07392990
59Anencephaly (HP:0002323)2.07162048
60Retinal dysplasia (HP:0007973)2.04865690
61Narrow forehead (HP:0000341)2.04436034
62Progressive cerebellar ataxia (HP:0002073)2.02694309
63Volvulus (HP:0002580)2.00227852
64Hypochromic microcytic anemia (HP:0004840)1.97396917
65Focal seizures (HP:0007359)1.97085541
66Congenital stationary night blindness (HP:0007642)1.95107523
67Tubular atrophy (HP:0000092)1.93989827
68Postaxial hand polydactyly (HP:0001162)1.91277970
69Neoplasm of the oral cavity (HP:0100649)1.90049671
70Cerebellar dysplasia (HP:0007033)1.89927952
71Broad alveolar ridges (HP:0000187)1.89880267
72Anophthalmia (HP:0000528)1.89873694
73Breast carcinoma (HP:0003002)1.89632514
74Abnormal rod and cone electroretinograms (HP:0008323)1.89542266
75Acute lymphatic leukemia (HP:0006721)1.87879768
76Absent speech (HP:0001344)1.86769046
77Duplicated collecting system (HP:0000081)1.85885793
78Nephroblastoma (Wilms tumor) (HP:0002667)1.85788410
79Hypoplastic pelvis (HP:0008839)1.85768874
80Limb hypertonia (HP:0002509)1.84686909
81Increased corneal curvature (HP:0100692)1.84653463
82Keratoconus (HP:0000563)1.84653463
83Neoplasm of the adrenal gland (HP:0100631)1.83833613
84Abolished electroretinogram (ERG) (HP:0000550)1.83611924
85Embryonal renal neoplasm (HP:0011794)1.82189286
86Tubulointerstitial nephritis (HP:0001970)1.81983395
87Abnormality of the renal cortex (HP:0011035)1.81635672
88Vaginal atresia (HP:0000148)1.80446396
89Genital tract atresia (HP:0001827)1.79436157
90Patellar aplasia (HP:0006443)1.78942036
91Dialeptic seizures (HP:0011146)1.78803896
92Limb dystonia (HP:0002451)1.77592447
93Posterior subcapsular cataract (HP:0007787)1.77461833
94Abnormality of the clitoris (HP:0000056)1.75380851
95Generalized hypopigmentation of hair (HP:0011358)1.75242564
96Abnormality of the renal collecting system (HP:0004742)1.75013820
97Large for gestational age (HP:0001520)1.74274660
98Cupped ear (HP:0000378)1.72165575
99Triphalangeal thumb (HP:0001199)1.72100261
100Abnormality of the pubic bones (HP:0003172)1.71146749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.77281127
2TAF14.79235223
3NUAK13.58815236
4SMG13.49980074
5TRIM282.67907436
6WNK32.59165883
7CASK2.57497923
8FRK2.23061144
9CSNK1G32.22430631
10EPHA32.21397501
11CSNK1A1L2.10541192
12CSNK1G12.07184326
13MAPK132.05909431
14TNIK2.05776038
15VRK12.03801071
16CSNK1G21.98007104
17PKN11.89903445
18PIK3CA1.86675805
19MAPKAPK51.84695042
20BUB11.83497913
21NME11.76980244
22ZAK1.71201898
23PIK3CG1.67405483
24DYRK31.67141683
25SRPK11.64668151
26EPHA41.57977717
27GRK51.55932980
28PLK31.53964530
29PBK1.53401787
30PLK41.46070297
31PAK31.36915649
32CDK91.32887542
33AKT31.27761077
34MAP4K21.27135490
35DYRK21.22245521
36BCKDK1.04305710
37STK161.01939063
38DYRK1A1.01350288
39ADRBK20.90137703
40EIF2AK20.87889812
41FER0.86842336
42CHEK20.84698733
43DAPK10.83491381
44TLK10.80698908
45PINK10.78680606
46MKNK20.74140678
47MAPKAPK30.71892403
48ERBB20.68623037
49BCR0.65422484
50EPHB20.60346687
51MELK0.59133040
52TTK0.57910340
53BRSK20.57201240
54BMPR1B0.56316422
55OXSR10.54610158
56WEE10.54118523
57ERBB40.53039340
58MARK10.52336017
59MKNK10.50654735
60ATR0.48811943
61NEK60.48704519
62PRKCG0.48634494
63PLK20.48464165
64MAPK110.44596717
65PLK10.43961426
66IRAK10.42392623
67CSNK1D0.42139154
68CDK80.41743532
69STK390.41448761
70PNCK0.41257246
71MAP3K20.40913076
72STK38L0.39697095
73RPS6KB10.39408099
74ACVR1B0.38676974
75ATM0.38570599
76TAOK30.36736399
77NEK10.36506803
78TESK20.36418191
79GRK10.35088657
80CDC70.34818741
81TGFBR10.34355312
82ERBB30.32934750
83PRKCE0.32398391
84PRKAA20.32149605
85INSRR0.30794824
86NLK0.30517569
87IKBKB0.29719907
88CDK180.29342203
89CDK70.29185692
90WNK40.28693451
91STK110.26290683
92CDK150.25242312
93DAPK30.25057994
94CCNB10.22658534
95DAPK20.21110665
96STK40.20699022
97FGFR30.20617226
98CDK10.20342412
99CDK50.20102088
100PTK2B0.17967913

Predicted pathways (KEGG)

RankGene SetZ-score
1Homologous recombination_Homo sapiens_hsa034403.13464460
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.07739221
3Non-homologous end-joining_Homo sapiens_hsa034503.02663251
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.98263319
5Mismatch repair_Homo sapiens_hsa034302.91136265
6Fanconi anemia pathway_Homo sapiens_hsa034602.63733803
7Steroid biosynthesis_Homo sapiens_hsa001002.38510956
8Phototransduction_Homo sapiens_hsa047442.34299530
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27708878
10Butanoate metabolism_Homo sapiens_hsa006502.24376065
11RNA degradation_Homo sapiens_hsa030182.14897590
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10206639
13Propanoate metabolism_Homo sapiens_hsa006402.08308641
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.07470090
15Base excision repair_Homo sapiens_hsa034101.98119595
16Proteasome_Homo sapiens_hsa030501.97029228
17RNA polymerase_Homo sapiens_hsa030201.95547043
18Nitrogen metabolism_Homo sapiens_hsa009101.91577402
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.84070149
20Sulfur relay system_Homo sapiens_hsa041221.84052614
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.67179521
22Protein export_Homo sapiens_hsa030601.66813253
23Lysine degradation_Homo sapiens_hsa003101.65114041
24DNA replication_Homo sapiens_hsa030301.58057498
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56853970
26Folate biosynthesis_Homo sapiens_hsa007901.55703496
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53448898
28Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.46347249
29beta-Alanine metabolism_Homo sapiens_hsa004101.43553485
30Linoleic acid metabolism_Homo sapiens_hsa005911.40174788
31Oxidative phosphorylation_Homo sapiens_hsa001901.35132843
32Nucleotide excision repair_Homo sapiens_hsa034201.35114102
33Spliceosome_Homo sapiens_hsa030401.24563190
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22361287
35RNA transport_Homo sapiens_hsa030131.19912912
36Basal cell carcinoma_Homo sapiens_hsa052171.18173980
37Tryptophan metabolism_Homo sapiens_hsa003801.17231769
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14906563
39Cell cycle_Homo sapiens_hsa041101.10933511
40p53 signaling pathway_Homo sapiens_hsa041151.08713726
41Ribosome_Homo sapiens_hsa030101.08173965
42Caffeine metabolism_Homo sapiens_hsa002321.06246370
43Ether lipid metabolism_Homo sapiens_hsa005651.05002425
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04988787
45One carbon pool by folate_Homo sapiens_hsa006701.01792154
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.99824112
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98443704
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98118198
49Parkinsons disease_Homo sapiens_hsa050120.96784332
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.95637764
51Basal transcription factors_Homo sapiens_hsa030220.92377574
52Nicotine addiction_Homo sapiens_hsa050330.90883135
53Arginine and proline metabolism_Homo sapiens_hsa003300.89129072
54Hedgehog signaling pathway_Homo sapiens_hsa043400.87064902
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85663366
56Huntingtons disease_Homo sapiens_hsa050160.85271741
57Collecting duct acid secretion_Homo sapiens_hsa049660.82167247
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.81409104
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79202457
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.77547418
61Oocyte meiosis_Homo sapiens_hsa041140.75706099
62Peroxisome_Homo sapiens_hsa041460.74852483
63Fatty acid degradation_Homo sapiens_hsa000710.73177709
64Histidine metabolism_Homo sapiens_hsa003400.63189374
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62775055
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62249354
67Purine metabolism_Homo sapiens_hsa002300.59980965
68Retinol metabolism_Homo sapiens_hsa008300.59623147
69Pyrimidine metabolism_Homo sapiens_hsa002400.57918633
70Pyruvate metabolism_Homo sapiens_hsa006200.57554088
71Selenocompound metabolism_Homo sapiens_hsa004500.48811360
72Metabolic pathways_Homo sapiens_hsa011000.48608994
73Olfactory transduction_Homo sapiens_hsa047400.48510841
74mRNA surveillance pathway_Homo sapiens_hsa030150.45936088
75Vitamin digestion and absorption_Homo sapiens_hsa049770.45753160
76Melanoma_Homo sapiens_hsa052180.45729180
77Amphetamine addiction_Homo sapiens_hsa050310.45544585
78Asthma_Homo sapiens_hsa053100.43888589
79Chemical carcinogenesis_Homo sapiens_hsa052040.43304261
80Intestinal immune network for IgA production_Homo sapiens_hsa046720.42864856
81Taste transduction_Homo sapiens_hsa047420.41867008
82Alzheimers disease_Homo sapiens_hsa050100.41660444
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41038502
84ABC transporters_Homo sapiens_hsa020100.41007057
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37004586
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36718200
87Glutathione metabolism_Homo sapiens_hsa004800.35362913
88Fatty acid metabolism_Homo sapiens_hsa012120.35220934
89Fat digestion and absorption_Homo sapiens_hsa049750.34483569
90Circadian rhythm_Homo sapiens_hsa047100.31630460
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.31335799
92TGF-beta signaling pathway_Homo sapiens_hsa043500.28119926
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27394937
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26950956
95Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24702102
96Mineral absorption_Homo sapiens_hsa049780.24488794
97MicroRNAs in cancer_Homo sapiens_hsa052060.24256512
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.24213653
99Arachidonic acid metabolism_Homo sapiens_hsa005900.23923208
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.23579865

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