RPL36P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine deamination (GO:0009972)8.22786308
2cytidine metabolic process (GO:0046087)8.22786308
3cytidine catabolic process (GO:0006216)8.22786308
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.69290461
5DNA deamination (GO:0045006)7.41748189
6pyrimidine ribonucleoside catabolic process (GO:0046133)7.37619766
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.45379168
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.35785384
9energy coupled proton transport, down electrochemical gradient (GO:0015985)5.21734458
10ATP synthesis coupled proton transport (GO:0015986)5.21734458
11ribosomal small subunit assembly (GO:0000028)5.08900887
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.81196585
13metallo-sulfur cluster assembly (GO:0031163)4.74673363
14iron-sulfur cluster assembly (GO:0016226)4.74673363
15maturation of SSU-rRNA (GO:0030490)4.71884963
16regulation of cilium movement (GO:0003352)4.49131178
17chaperone-mediated protein transport (GO:0072321)4.44323420
18protein neddylation (GO:0045116)4.43698931
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.40086700
20respiratory electron transport chain (GO:0022904)4.35934826
21electron transport chain (GO:0022900)4.31943711
22viral transcription (GO:0019083)4.24377285
23cytolysis (GO:0019835)4.11840200
24translational termination (GO:0006415)4.06896607
25negative regulation by host of viral transcription (GO:0043922)3.98016042
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.91919389
27sequestering of actin monomers (GO:0042989)3.88367920
28regulation of regulatory T cell differentiation (GO:0045589)3.83965582
29translational elongation (GO:0006414)3.80111319
30positive T cell selection (GO:0043368)3.79627786
31positive thymic T cell selection (GO:0045059)3.75736133
32positive regulation of defense response to virus by host (GO:0002230)3.73533547
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.65531008
34positive regulation of interleukin-8 secretion (GO:2000484)3.64572836
35actin nucleation (GO:0045010)3.60957822
36ubiquinone biosynthetic process (GO:0006744)3.60881715
37protein targeting to ER (GO:0045047)3.56247339
38ribosomal small subunit biogenesis (GO:0042274)3.55339690
39positive regulation of calcium-mediated signaling (GO:0050850)3.54921740
40cotranslational protein targeting to membrane (GO:0006613)3.54690876
41pyrimidine nucleoside catabolic process (GO:0046135)3.45973777
42response to pheromone (GO:0019236)3.44158991
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.42365752
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.42365752
45protein localization to endoplasmic reticulum (GO:0070972)3.42185912
46termination of RNA polymerase III transcription (GO:0006386)3.39938381
47transcription elongation from RNA polymerase III promoter (GO:0006385)3.39938381
48establishment of protein localization to endoplasmic reticulum (GO:0072599)3.35106419
49ubiquinone metabolic process (GO:0006743)3.26109355
50hydrogen ion transmembrane transport (GO:1902600)3.25052039
51positive regulation of T cell apoptotic process (GO:0070234)3.23400430
52negative regulation of viral genome replication (GO:0045071)3.21760910
53indolalkylamine metabolic process (GO:0006586)3.18669699
54DNA demethylation (GO:0080111)3.18183596
55epithelial cilium movement (GO:0003351)3.14052183
56cellular protein complex disassembly (GO:0043624)3.13342380
57positive regulation of tolerance induction (GO:0002645)3.05967741
58viral life cycle (GO:0019058)2.98029802
59piRNA metabolic process (GO:0034587)2.91774476
60proton transport (GO:0015992)2.91589560
61DNA dealkylation (GO:0035510)2.90990800
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90661845
63ATP biosynthetic process (GO:0006754)2.90480332
64eosinophil chemotaxis (GO:0048245)2.90375598
65quinone biosynthetic process (GO:1901663)2.88471331
66intracellular protein transmembrane import (GO:0044743)2.88305647
67positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.88007657
68axonemal dynein complex assembly (GO:0070286)2.86606290
69hydrogen transport (GO:0006818)2.85185211
70respiratory chain complex IV assembly (GO:0008535)2.84990185
71regulation of microtubule-based movement (GO:0060632)2.84221048
72positive regulation of natural killer cell mediated immunity (GO:0002717)2.82182998
73mast cell degranulation (GO:0043303)2.81477315
74mast cell activation involved in immune response (GO:0002279)2.81477315
75pseudouridine synthesis (GO:0001522)2.80278300
76positive regulation of gamma-delta T cell activation (GO:0046645)2.80173989
77water-soluble vitamin biosynthetic process (GO:0042364)2.79448690
78negative regulation of viral transcription (GO:0032897)2.78608521
79pyrimidine-containing compound catabolic process (GO:0072529)2.78167953
80negative regulation of T cell apoptotic process (GO:0070233)2.78007446
81nonmotile primary cilium assembly (GO:0035058)2.75134923
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75024641
83cytochrome complex assembly (GO:0017004)2.74539452
84positive regulation of interleukin-1 beta secretion (GO:0050718)2.73884571
85platelet dense granule organization (GO:0060155)2.73622486
86protein complex biogenesis (GO:0070271)2.71069488
87regulation of interleukin-8 secretion (GO:2000482)2.70635851
88translation (GO:0006412)2.70406502
89regulation of cellular amino acid metabolic process (GO:0006521)2.70199657
90inner mitochondrial membrane organization (GO:0007007)2.68252787
91negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.66126718
92regulation of natural killer cell mediated immunity (GO:0002715)2.65719371
93regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.65719371
94regulation of T cell tolerance induction (GO:0002664)2.64821114
95eosinophil migration (GO:0072677)2.64208996
96behavioral response to nicotine (GO:0035095)2.63500931
97regulation of defense response to virus by host (GO:0050691)2.62433323
98cellular response to interleukin-15 (GO:0071350)2.61765612
99positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.60805534
100positive regulation of lymphocyte apoptotic process (GO:0070230)2.60310730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.48600011
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.79161775
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31938232
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.24411497
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.23571336
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.12715381
7VDR_22108803_ChIP-Seq_LS180_Human3.09140069
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.96963177
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.92986113
10EZH2_22144423_ChIP-Seq_EOC_Human2.86596824
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.75044442
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61055376
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.53051069
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.48723088
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.27698264
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.25420805
17VDR_23849224_ChIP-Seq_CD4+_Human2.13211641
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.07751571
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99139993
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98998917
21CREB1_15753290_ChIP-ChIP_HEK293T_Human1.84358608
22IGF1R_20145208_ChIP-Seq_DFB_Human1.75807856
23YY1_21170310_ChIP-Seq_MESCs_Mouse1.73920787
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.57989225
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56179121
26AUTS2_25519132_ChIP-Seq_293T-REX_Human1.55896025
27ELK1_19687146_ChIP-ChIP_HELA_Human1.54475097
28FOXA1_27270436_Chip-Seq_PROSTATE_Human1.52187032
29FOXA1_25329375_ChIP-Seq_VCAP_Human1.52187032
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.49309773
31SRF_21415370_ChIP-Seq_HL-1_Mouse1.47921907
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.47446535
33NANOG_20526341_ChIP-Seq_ESCs_Human1.47273632
34FOXP3_21729870_ChIP-Seq_TREG_Human1.46034851
35STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45812990
36AR_20517297_ChIP-Seq_VCAP_Human1.44429042
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43001168
38EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41346690
39HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33976937
40BCL6_27268052_Chip-Seq_Bcells_Human1.33917965
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.33898156
42TP53_22573176_ChIP-Seq_HFKS_Human1.32437642
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32323266
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.27995346
45TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24602785
46STAT1_20625510_ChIP-Seq_HELA_Human1.24602365
47FOXH1_21741376_ChIP-Seq_EPCs_Human1.22275703
48ERA_21632823_ChIP-Seq_H3396_Human1.21975499
49HTT_18923047_ChIP-ChIP_STHdh_Human1.21697302
50GATA3_21878914_ChIP-Seq_MCF-7_Human1.19689431
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.19216111
52NCOR_22424771_ChIP-Seq_293T_Human1.16313883
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15728070
54YY1_22570637_ChIP-Seq_MALME-3M_Human1.15196663
55ETV2_25802403_ChIP-Seq_MESCs_Mouse1.14442416
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13442293
57GATA3_26560356_Chip-Seq_TH2_Human1.11967040
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.11808189
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.09088152
60GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.08229664
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08193365
62MYB_26560356_Chip-Seq_TH2_Human1.07739199
63TAF2_19829295_ChIP-Seq_ESCs_Human1.06741707
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05032120
65MYC_18940864_ChIP-ChIP_HL60_Human1.04344042
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.02744820
67OCT4_20526341_ChIP-Seq_ESCs_Human1.02414250
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.02082433
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00347488
70MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99444617
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98723361
72MYC_19829295_ChIP-Seq_ESCs_Human0.98276881
73FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98131142
74EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.97668313
75FLI1_27457419_Chip-Seq_LIVER_Mouse0.97246480
76ERG_20517297_ChIP-Seq_VCAP_Human0.96955958
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96520940
78P300_27268052_Chip-Seq_Bcells_Human0.96070767
79RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95931275
80PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94495823
81ELK1_22589737_ChIP-Seq_MCF10A_Human0.94176818
82P53_21459846_ChIP-Seq_SAOS-2_Human0.93849236
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93650489
84CBP_20019798_ChIP-Seq_JUKART_Human0.93650489
85GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93310053
86EWS_26573619_Chip-Seq_HEK293_Human0.92153106
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91922406
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91570911
89HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91175510
90SA1_27219007_Chip-Seq_Bcells_Human0.91135226
91SOX2_19829295_ChIP-Seq_ESCs_Human0.90708960
92NANOG_19829295_ChIP-Seq_ESCs_Human0.90708960
93GATA3_27048872_Chip-Seq_THYMUS_Human0.89719479
94RBPJ_21746931_ChIP-Seq_IB4_Human0.89595994
95CTCF_20526341_ChIP-Seq_ESCs_Human0.89153382
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89026048
97ELF1_20517297_ChIP-Seq_JURKAT_Human0.89022255
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.88649288
99RNF2_27304074_Chip-Seq_NSC_Mouse0.87861445
100TTF2_22483619_ChIP-Seq_HELA_Human0.87850993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.11012136
2MP0009379_abnormal_foot_pigmentation3.23080342
3MP0002638_abnormal_pupillary_reflex2.66142646
4MP0003787_abnormal_imprinting2.48760804
5MP0006082_CNS_inflammation2.40744039
6MP0005646_abnormal_pituitary_gland2.40584718
7MP0003878_abnormal_ear_physiology2.37057087
8MP0005377_hearing/vestibular/ear_phenot2.37057087
9MP0001529_abnormal_vocalization2.25283653
10MP0006292_abnormal_olfactory_placode2.20150352
11MP0009785_altered_susceptibility_to2.13644949
12MP0003195_calcinosis2.10545919
13MP0003123_paternal_imprinting2.00309581
14MP0001485_abnormal_pinna_reflex1.88389646
15MP0009333_abnormal_splenocyte_physiolog1.88029503
16MP0006072_abnormal_retinal_apoptosis1.84429172
17MP0002148_abnormal_hypersensitivity_rea1.81638299
18MP0008877_abnormal_DNA_methylation1.76218253
19MP0001968_abnormal_touch/_nociception1.73743738
20MP0002163_abnormal_gland_morphology1.66637535
21MP0003866_abnormal_defecation1.65448430
22MP0002102_abnormal_ear_morphology1.65097774
23MP0008872_abnormal_physiological_respon1.63675168
24MP0001905_abnormal_dopamine_level1.63302386
25MP0005000_abnormal_immune_tolerance1.56102714
26MP0004885_abnormal_endolymph1.54948000
27MP0006276_abnormal_autonomic_nervous1.54128766
28MP0003724_increased_susceptibility_to1.51998116
29MP0005084_abnormal_gallbladder_morpholo1.51925943
30MP0002277_abnormal_respiratory_mucosa1.50604063
31MP0001835_abnormal_antigen_presentation1.48425569
32MP0008875_abnormal_xenobiotic_pharmacok1.48235650
33MP0005645_abnormal_hypothalamus_physiol1.45139343
34MP0002876_abnormal_thyroid_physiology1.43170149
35MP0001986_abnormal_taste_sensitivity1.42913162
36MP0005025_abnormal_response_to1.39714167
37MP0001800_abnormal_humoral_immune1.35428820
38MP0003763_abnormal_thymus_physiology1.33900608
39MP0006035_abnormal_mitochondrial_morpho1.33817679
40MP0002736_abnormal_nociception_after1.31984154
41MP0002723_abnormal_immune_serum1.31335602
42MP0005253_abnormal_eye_physiology1.31198762
43MP0001873_stomach_inflammation1.30255747
44MP0002420_abnormal_adaptive_immunity1.28587293
45MP0008789_abnormal_olfactory_epithelium1.28068823
46MP0005551_abnormal_eye_electrophysiolog1.27596485
47MP0005389_reproductive_system_phenotype1.26882666
48MP0001819_abnormal_immune_cell1.26070725
49MP0001984_abnormal_olfaction1.23609546
50MP0002837_dystrophic_cardiac_calcinosis1.23547043
51MP0001764_abnormal_homeostasis1.22765629
52MP0010155_abnormal_intestine_physiology1.22143640
53MP0002138_abnormal_hepatobiliary_system1.21030098
54MP0004742_abnormal_vestibular_system1.18349652
55MP0009764_decreased_sensitivity_to1.17745150
56MP0003879_abnormal_hair_cell1.16970086
57MP0000372_irregular_coat_pigmentation1.16601069
58MP0002160_abnormal_reproductive_system1.13373517
59MP0005379_endocrine/exocrine_gland_phen1.11534886
60MP0005083_abnormal_biliary_tract1.08800862
61MP0006036_abnormal_mitochondrial_physio1.07752619
62MP0005387_immune_system_phenotype1.03876547
63MP0001790_abnormal_immune_system1.03876547
64MP0001970_abnormal_pain_threshold1.02178323
65MP0003011_delayed_dark_adaptation1.00000004
66MP0002254_reproductive_system_inflammat0.99303463
67MP0002452_abnormal_antigen_presenting0.99275416
68MP0005410_abnormal_fertilization0.99089175
69MP0001765_abnormal_ion_homeostasis0.98248705
70MP0002735_abnormal_chemical_nociception0.98220057
71MP0005085_abnormal_gallbladder_physiolo0.97161908
72MP0003136_yellow_coat_color0.96639967
73MP0000716_abnormal_immune_system0.96112548
74MP0004142_abnormal_muscle_tone0.95721019
75MP0000631_abnormal_neuroendocrine_gland0.93875357
76MP0002933_joint_inflammation0.92453239
77MP0002272_abnormal_nervous_system0.91408617
78MP0004130_abnormal_muscle_cell0.91339411
79MP0001919_abnormal_reproductive_system0.91160909
80MP0001293_anophthalmia0.90885647
81MP0005499_abnormal_olfactory_system0.89524885
82MP0005394_taste/olfaction_phenotype0.89524885
83MP0004147_increased_porphyrin_level0.88742332
84MP0002733_abnormal_thermal_nociception0.87871332
85MP0002734_abnormal_mechanical_nocicepti0.87012183
86MP0003119_abnormal_digestive_system0.86850831
87MP0001845_abnormal_inflammatory_respons0.86116769
88MP0009745_abnormal_behavioral_response0.85889549
89MP0003315_abnormal_perineum_morphology0.83963494
90MP0003646_muscle_fatigue0.82417906
91MP0004947_skin_inflammation0.80241191
92MP0005636_abnormal_mineral_homeostasis0.80157286
93MP0002398_abnormal_bone_marrow0.79171133
94MP0002234_abnormal_pharynx_morphology0.78716260
95MP0000230_abnormal_systemic_arterial0.77551605
96MP0000689_abnormal_spleen_morphology0.76623875
97MP0003786_premature_aging0.75746839
98MP0003252_abnormal_bile_duct0.75517519
99MP0005360_urolithiasis0.75368041
100MP0002006_tumorigenesis0.75297487

Predicted human phenotypes

RankGene SetZ-score
1Increased hepatocellular lipid droplets (HP:0006565)4.29918182
2Mitochondrial inheritance (HP:0001427)4.21123848
3Elevated erythrocyte sedimentation rate (HP:0003565)4.14429164
4Increased intramyocellular lipid droplets (HP:0012240)4.04210468
5Acute necrotizing encephalopathy (HP:0006965)4.01136853
6Molar tooth sign on MRI (HP:0002419)3.97861686
7Abnormality of midbrain morphology (HP:0002418)3.97861686
8Pancreatic cysts (HP:0001737)3.92604860
9Abnormal mitochondria in muscle tissue (HP:0008316)3.85414300
10Lipid accumulation in hepatocytes (HP:0006561)3.76266643
11Pancreatic fibrosis (HP:0100732)3.75269658
12True hermaphroditism (HP:0010459)3.66276566
13Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55703849
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.49887270
15Reticulocytopenia (HP:0001896)3.47120649
163-Methylglutaconic aciduria (HP:0003535)3.43815927
17Increased CSF lactate (HP:0002490)3.41811642
18Acute encephalopathy (HP:0006846)3.40469203
19Abnormal respiratory motile cilium morphology (HP:0005938)3.34327176
20Abnormal respiratory epithelium morphology (HP:0012253)3.34327176
21Increased muscle lipid content (HP:0009058)3.32140191
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.30869372
23Absent/shortened dynein arms (HP:0200106)3.30869372
24Increased IgM level (HP:0003496)3.28362343
25Renal Fanconi syndrome (HP:0001994)3.26561673
26Hepatocellular necrosis (HP:0001404)3.14050268
27Progressive macrocephaly (HP:0004481)3.12929552
28IgG deficiency (HP:0004315)3.10042211
29Decreased activity of mitochondrial respiratory chain (HP:0008972)3.06789485
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.06789485
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93886787
32Abnormal number of erythroid precursors (HP:0012131)2.90328708
33Abnormality of cells of the erythroid lineage (HP:0012130)2.90066267
34Bile duct proliferation (HP:0001408)2.86397695
35Abnormal biliary tract physiology (HP:0012439)2.86397695
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.85104108
37Hepatic necrosis (HP:0002605)2.77778614
38Chronic bronchitis (HP:0004469)2.68978030
39Abnormality of T cell number (HP:0011839)2.68193935
40T lymphocytopenia (HP:0005403)2.62195925
41Exertional dyspnea (HP:0002875)2.59463868
42Decreased central vision (HP:0007663)2.58628211
43Cystic liver disease (HP:0006706)2.57441617
44Optic disc pallor (HP:0000543)2.56600785
45Macrocytic anemia (HP:0001972)2.55675307
46Severe combined immunodeficiency (HP:0004430)2.52602047
47Congenital stationary night blindness (HP:0007642)2.52003257
48Aplastic anemia (HP:0001915)2.50418443
49Cerebral edema (HP:0002181)2.49587460
50Autoimmune hemolytic anemia (HP:0001890)2.48521480
51Abnormal rod and cone electroretinograms (HP:0008323)2.47584497
52Abnormality of renal resorption (HP:0011038)2.46482196
53Abnormal respiratory motile cilium physiology (HP:0012261)2.40499236
54Aplasia/hypoplasia of the uterus (HP:0008684)2.29687881
55Sclerocornea (HP:0000647)2.25144663
56Abnormal ciliary motility (HP:0012262)2.23702316
57Increased serum lactate (HP:0002151)2.22573555
58Respiratory difficulties (HP:0002880)2.21862856
59Colon cancer (HP:0003003)2.12144618
60Lactic acidosis (HP:0003128)2.11808641
61Bronchiectasis (HP:0002110)2.08113237
62Abnormality of eosinophils (HP:0001879)2.06685992
63Hypomagnesemia (HP:0002917)2.06064003
64Chronic hepatic failure (HP:0100626)2.03335066
65Exercise intolerance (HP:0003546)2.03220304
66Pallor (HP:0000980)2.02853556
67Attenuation of retinal blood vessels (HP:0007843)1.98809844
68Hypoplasia of the uterus (HP:0000013)1.97027618
69Chronic sinusitis (HP:0011109)1.95232658
70Bronchitis (HP:0012387)1.94668215
71Anencephaly (HP:0002323)1.94432005
72Aplasia/Hypoplasia of the tongue (HP:0010295)1.93039582
73Pendular nystagmus (HP:0012043)1.92865524
74Rhinitis (HP:0012384)1.91480526
75Nephronophthisis (HP:0000090)1.91119142
76Medial flaring of the eyebrow (HP:0010747)1.91032130
77Stenosis of the external auditory canal (HP:0000402)1.90110152
78Combined immunodeficiency (HP:0005387)1.90029936
79Hypergammaglobulinemia (HP:0010702)1.89034666
80Supernumerary spleens (HP:0009799)1.87187048
81Brushfield spots (HP:0001088)1.86463751
82Abnormality of magnesium homeostasis (HP:0004921)1.86040188
83Oligomenorrhea (HP:0000876)1.85724020
84Abnormality of T cells (HP:0002843)1.81520757
85Hyperphosphaturia (HP:0003109)1.80993665
86Eosinophilia (HP:0001880)1.80287562
87Respiratory failure (HP:0002878)1.79149914
88Male pseudohermaphroditism (HP:0000037)1.78571309
89Abnormality of DNA repair (HP:0003254)1.78288367
90Hypoplasia of the pons (HP:0012110)1.77197442
91Abnormality of urine glucose concentration (HP:0011016)1.77070308
92Glycosuria (HP:0003076)1.77070308
93Abnormality of the pons (HP:0007361)1.76846314
94Abnormality of the renal collecting system (HP:0004742)1.76066596
95Recurrent otitis media (HP:0000403)1.75223351
96Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.74875933
97Abolished electroretinogram (ERG) (HP:0000550)1.74074825
98Type II lissencephaly (HP:0007260)1.72150873
99Erythema (HP:0010783)1.71347873
100Cerebral palsy (HP:0100021)1.70039827

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK6.42309794
2TLK14.87939971
3KDR3.59599897
4VRK23.46779695
5TESK23.10681889
6WNK32.57587200
7BCKDK2.50868062
8SIK22.45355774
9VRK12.41546646
10TIE12.39951763
11STK162.13019269
12ADRBK22.05570311
13LIMK12.01294430
14WNK41.92778841
15MAP4K21.82624701
16TRIM281.77818580
17TXK1.75057086
18GRK11.74452622
19PIK3CA1.68433769
20MAP4K11.56819821
21TNIK1.49351084
22TESK11.48621763
23BUB11.42106565
24MAP2K71.38065694
25CASK1.30138081
26FRK1.26878492
27BMPR1B1.26115139
28TNK21.25302187
29MAP3K121.24218072
30NEK21.14956328
31ITK1.11672674
32TAOK31.09253230
33MAP3K111.04611457
34MAP3K41.03989999
35SRPK11.03548722
36DAPK10.98508779
37DAPK20.97415497
38PLK20.94819404
39PRKCQ0.94080415
40PIM20.92323268
41NUAK10.89340323
42ZAP700.86841625
43IKBKB0.80870798
44GRK70.75767467
45DYRK20.75341901
46MARK30.74411557
47PIM10.73476996
48PAK60.71221617
49RPS6KA50.70496151
50PLK30.69975527
51CSNK1G30.68599250
52CSNK1G20.64968577
53PINK10.64461003
54BCR0.63594923
55MST40.62617306
56TEC0.62562283
57LCK0.61959054
58MAPK130.60175323
59PLK40.58799260
60DAPK30.57506689
61EPHB20.55918744
62ADRBK10.54353170
63SYK0.53578764
64SCYL20.52658053
65INSRR0.50867669
66CSNK1A1L0.50017645
67LYN0.49499585
68MAP2K60.49223903
69CDC70.47871626
70PASK0.47409807
71CSNK1G10.45347276
72MYLK0.44225529
73ACVR1B0.43297550
74PIK3CG0.42358364
75KIT0.41903118
76TTK0.41541658
77MAP3K50.41169198
78BRAF0.40682890
79PRKD30.39148440
80PRKCE0.38915698
81AKT30.38116566
82CSF1R0.37078097
83PRKCA0.36472594
84ROCK10.36459289
85CDK80.34823409
86PRKCG0.34599508
87PKN10.33809282
88CSNK2A10.32720912
89PLK10.32439993
90OBSCN0.29831342
91FES0.29770793
92CSNK1A10.29394882
93AURKA0.29373865
94PRKACA0.28852879
95JAK30.28778222
96MINK10.28734128
97SIK30.27977884
98NTRK20.27785124
99CSNK2A20.27774392
100PRKCD0.27299480

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.54420624
2Ribosome_Homo sapiens_hsa030104.27687905
3Primary immunodeficiency_Homo sapiens_hsa053403.90432782
4Parkinsons disease_Homo sapiens_hsa050123.78272984
5Proteasome_Homo sapiens_hsa030503.69498020
6RNA polymerase_Homo sapiens_hsa030202.77813707
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.70781503
8Nitrogen metabolism_Homo sapiens_hsa009102.65169506
9Cardiac muscle contraction_Homo sapiens_hsa042602.50156554
10Huntingtons disease_Homo sapiens_hsa050162.49343084
11Alzheimers disease_Homo sapiens_hsa050102.47390432
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38727819
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.33034942
14Graft-versus-host disease_Homo sapiens_hsa053322.32041326
15Allograft rejection_Homo sapiens_hsa053301.77550343
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.69463188
17Autoimmune thyroid disease_Homo sapiens_hsa053201.67027642
18Peroxisome_Homo sapiens_hsa041461.62579386
19Antigen processing and presentation_Homo sapiens_hsa046121.62320020
20Linoleic acid metabolism_Homo sapiens_hsa005911.60772918
21Hematopoietic cell lineage_Homo sapiens_hsa046401.59543225
22Phototransduction_Homo sapiens_hsa047441.58082438
23Type I diabetes mellitus_Homo sapiens_hsa049401.50688810
24Tryptophan metabolism_Homo sapiens_hsa003801.44058026
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43822814
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.40626038
27Butanoate metabolism_Homo sapiens_hsa006501.35280438
28Rheumatoid arthritis_Homo sapiens_hsa053231.28766618
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.22062246
30Caffeine metabolism_Homo sapiens_hsa002321.13025195
31Homologous recombination_Homo sapiens_hsa034401.11871561
32T cell receptor signaling pathway_Homo sapiens_hsa046601.02949433
33Selenocompound metabolism_Homo sapiens_hsa004500.95661700
34Protein export_Homo sapiens_hsa030600.95367308
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95325188
36Salmonella infection_Homo sapiens_hsa051320.93165995
37Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87823979
38Malaria_Homo sapiens_hsa051440.83585085
39One carbon pool by folate_Homo sapiens_hsa006700.80585656
40Retinol metabolism_Homo sapiens_hsa008300.79580399
41Primary bile acid biosynthesis_Homo sapiens_hsa001200.78957560
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77791495
43RNA degradation_Homo sapiens_hsa030180.77457640
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.73564870
45Regulation of autophagy_Homo sapiens_hsa041400.73210071
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.72281711
47Olfactory transduction_Homo sapiens_hsa047400.72224195
48Collecting duct acid secretion_Homo sapiens_hsa049660.71163503
49ABC transporters_Homo sapiens_hsa020100.71056983
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67686681
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67025323
52Ether lipid metabolism_Homo sapiens_hsa005650.64175026
53Systemic lupus erythematosus_Homo sapiens_hsa053220.61737396
54Pyrimidine metabolism_Homo sapiens_hsa002400.61162501
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59860107
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59731194
57Mineral absorption_Homo sapiens_hsa049780.59287953
58Asthma_Homo sapiens_hsa053100.58749798
59Nicotine addiction_Homo sapiens_hsa050330.58188318
60Purine metabolism_Homo sapiens_hsa002300.58017247
61NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57124898
62Spliceosome_Homo sapiens_hsa030400.56788479
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56576186
64Metabolic pathways_Homo sapiens_hsa011000.56367291
65Fatty acid degradation_Homo sapiens_hsa000710.56126741
66Steroid hormone biosynthesis_Homo sapiens_hsa001400.55111263
67Arachidonic acid metabolism_Homo sapiens_hsa005900.52748426
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52446501
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.51251150
70Measles_Homo sapiens_hsa051620.50306055
71Chemical carcinogenesis_Homo sapiens_hsa052040.47205327
72Basal transcription factors_Homo sapiens_hsa030220.45365725
73Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42744724
74Propanoate metabolism_Homo sapiens_hsa006400.42386039
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42197180
76Nucleotide excision repair_Homo sapiens_hsa034200.41802382
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41777573
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.40531402
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.39630645
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37839721
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36035686
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35792730
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35471997
84beta-Alanine metabolism_Homo sapiens_hsa004100.32698698
85Fanconi anemia pathway_Homo sapiens_hsa034600.30660139
86Shigellosis_Homo sapiens_hsa051310.28716224
87Fatty acid elongation_Homo sapiens_hsa000620.27499957
88African trypanosomiasis_Homo sapiens_hsa051430.27490525
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27391925
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.26585922
91Fat digestion and absorption_Homo sapiens_hsa049750.26239489
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26203865
93Pyruvate metabolism_Homo sapiens_hsa006200.23140825
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.22083435
95Taste transduction_Homo sapiens_hsa047420.22038995
96Morphine addiction_Homo sapiens_hsa050320.18621524
97RNA transport_Homo sapiens_hsa030130.18170179
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.18037794
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.16145824
100Mismatch repair_Homo sapiens_hsa034300.14830895

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