RPL37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* cotranslational protein targeting to membrane (GO:0006613)9.91927329
2* protein targeting to ER (GO:0045047)9.88193741
3* translational elongation (GO:0006414)9.79571383
4* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.46201200
5* cellular protein complex disassembly (GO:0043624)9.26686448
6* protein localization to endoplasmic reticulum (GO:0070972)9.23326506
7* viral life cycle (GO:0019058)9.15891547
8* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)8.90370312
9maturation of SSU-rRNA (GO:0030490)8.71720151
10* translational initiation (GO:0006413)8.24232533
11* protein complex disassembly (GO:0043241)7.92037441
12ribosomal large subunit biogenesis (GO:0042273)7.86687964
13* macromolecular complex disassembly (GO:0032984)7.42824152
14* protein targeting to membrane (GO:0006612)6.58713327
15* nuclear-transcribed mRNA catabolic process (GO:0000956)6.05234871
16* translation (GO:0006412)6.03160897
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.96498271
18* mRNA catabolic process (GO:0006402)5.73744031
19ATP synthesis coupled proton transport (GO:0015986)5.69645606
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.69645606
21ribonucleoprotein complex biogenesis (GO:0022613)5.31319715
22* RNA catabolic process (GO:0006401)5.19174497
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.68505571
24* establishment of protein localization to membrane (GO:0090150)4.52329131
25cellular component biogenesis (GO:0044085)4.30079797
26respiratory electron transport chain (GO:0022904)4.26721220
27GTP biosynthetic process (GO:0006183)4.18540556
28* protein targeting (GO:0006605)4.16919958
29electron transport chain (GO:0022900)4.16282122
30rRNA processing (GO:0006364)4.08478908
31* establishment of protein localization to organelle (GO:0072594)3.96477304
32rRNA metabolic process (GO:0016072)3.92802086
33UTP biosynthetic process (GO:0006228)3.80403712
34protein neddylation (GO:0045116)3.75429730
35termination of RNA polymerase III transcription (GO:0006386)3.63875280
36transcription elongation from RNA polymerase III promoter (GO:0006385)3.63875280
37* protein localization to membrane (GO:0072657)3.50648969
38spliceosomal complex assembly (GO:0000245)3.46717179
39ncRNA 3-end processing (GO:0043628)3.46304912
40establishment of protein localization to mitochondrial membrane (GO:0090151)3.41773417
41DNA deamination (GO:0045006)3.32539167
42UTP metabolic process (GO:0046051)3.24804957
43establishment of integrated proviral latency (GO:0075713)3.24691778
44spliceosomal snRNP assembly (GO:0000387)3.22242256
45formation of translation preinitiation complex (GO:0001731)3.19175861
46regulation of translational fidelity (GO:0006450)3.08693060
47protein complex biogenesis (GO:0070271)3.06618198
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.04474977
49NADH dehydrogenase complex assembly (GO:0010257)3.04474977
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.04474977
51CTP biosynthetic process (GO:0006241)3.04399438
52CTP metabolic process (GO:0046036)3.04399438
53DNA strand elongation involved in DNA replication (GO:0006271)3.03299215
54proteasome assembly (GO:0043248)3.02139515
55DNA replication checkpoint (GO:0000076)2.99362558
56guanosine-containing compound biosynthetic process (GO:1901070)2.96027521
57* cellular component disassembly (GO:0022411)2.95317005
58inner mitochondrial membrane organization (GO:0007007)2.91651867
59DNA strand elongation (GO:0022616)2.91378056
60exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89666396
61ribosome biogenesis (GO:0042254)2.87830971
62* protein localization to organelle (GO:0033365)2.87111732
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.86419597
64pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.84041827
65mitochondrial respiratory chain complex assembly (GO:0033108)2.83966646
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83818973
67transcription elongation from RNA polymerase I promoter (GO:0006362)2.79142594
68negative regulation of RNA splicing (GO:0033119)2.78991715
69oxidative phosphorylation (GO:0006119)2.77691606
70heterochromatin organization (GO:0070828)2.77046579
71purine nucleoside triphosphate biosynthetic process (GO:0009145)2.76423749
72chromatin remodeling at centromere (GO:0031055)2.76182496
73folic acid metabolic process (GO:0046655)2.75905081
74establishment of viral latency (GO:0019043)2.74906758
75regulation of mitochondrial translation (GO:0070129)2.74527066
76pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.74316310
77pseudouridine synthesis (GO:0001522)2.73497873
78DNA damage response, detection of DNA damage (GO:0042769)2.70501919
79termination of RNA polymerase I transcription (GO:0006363)2.68287055
80CENP-A containing nucleosome assembly (GO:0034080)2.67814338
81chaperone-mediated protein transport (GO:0072321)2.65710385
82protein targeting to mitochondrion (GO:0006626)2.61678608
83DNA unwinding involved in DNA replication (GO:0006268)2.60963339
84ribonucleoprotein complex assembly (GO:0022618)2.60825567
85ncRNA processing (GO:0034470)2.60167216
86ribonucleoside triphosphate biosynthetic process (GO:0009201)2.59282074
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.59271673
88mitotic chromosome condensation (GO:0007076)2.57981138
897-methylguanosine mRNA capping (GO:0006370)2.56608095
90RNA capping (GO:0036260)2.55495182
917-methylguanosine RNA capping (GO:0009452)2.55495182
92homocysteine metabolic process (GO:0050667)2.54600685
93transcription from RNA polymerase I promoter (GO:0006360)2.54346496
94rRNA modification (GO:0000154)2.53180996
95establishment of protein localization to mitochondrion (GO:0072655)2.52262975
96negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.51612315
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.49427916
98* gene expression (GO:0010467)2.49360058
99sequestering of actin monomers (GO:0042989)2.49293630
100ATP biosynthetic process (GO:0006754)2.48670751
101pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.48365378
102ribonucleoprotein complex subunit organization (GO:0071826)2.47397509
103aerobic respiration (GO:0009060)2.46955501
104transcription-coupled nucleotide-excision repair (GO:0006283)2.44674069
105telomere maintenance via semi-conservative replication (GO:0032201)2.43396423
106respiratory chain complex IV assembly (GO:0008535)2.39390371
107antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39183560
108DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38848222
109histone mRNA metabolic process (GO:0008334)2.38776200
110telomere maintenance via recombination (GO:0000722)2.38180356
111negative regulation of ligase activity (GO:0051352)2.35894387
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.35894387
113purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.35355217
114purine nucleoside monophosphate biosynthetic process (GO:0009127)2.35355217
115ncRNA metabolic process (GO:0034660)2.33950342
116signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.32125085
117intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.32125085
118protein localization to mitochondrion (GO:0070585)2.31907748
119kinetochore organization (GO:0051383)2.31794341
120hydrogen ion transmembrane transport (GO:1902600)2.31024682
121nucleoside triphosphate biosynthetic process (GO:0009142)2.30347307
122RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.30237213
123mRNA splicing, via spliceosome (GO:0000398)2.30237213
124intracellular protein transmembrane import (GO:0044743)2.29167476
125mitotic sister chromatid segregation (GO:0000070)2.27368201
126RNA splicing, via transesterification reactions (GO:0000375)2.25796190
127* viral transcription (GO:0019083)12.3845070
128* translational termination (GO:0006415)11.8444367
129ribosomal small subunit biogenesis (GO:0042274)11.4933410
130ribosomal small subunit assembly (GO:0000028)10.6958207
131* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)10.0334541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.95268162
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.24591869
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.06384851
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.02320722
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse4.00258138
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.86353813
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.83222411
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.62421211
9E2F7_22180533_ChIP-Seq_HELA_Human3.57952773
10* ETS1_20019798_ChIP-Seq_JURKAT_Human3.57074253
11TP63_17297297_ChIP-ChIP_HaCaT_Human3.38980324
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31097538
13* CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.16870512
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03065299
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02025131
16* XRN2_22483619_ChIP-Seq_HELA_Human2.98388282
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95084852
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91278839
19* TTF2_22483619_ChIP-Seq_HELA_Human2.82989016
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75963952
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55750691
22* VDR_23849224_ChIP-Seq_CD4+_Human2.45239879
23ELK1_19687146_ChIP-ChIP_HELA_Human2.43372935
24* DCP1A_22483619_ChIP-Seq_HELA_Human2.37311311
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30026451
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.23428337
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23374924
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16470974
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.12858999
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10533232
31* ELK1_22589737_ChIP-Seq_MCF10A_Human2.01584795
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01076451
33* FOXP3_21729870_ChIP-Seq_TREG_Human1.98274487
34* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.86650720
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.86245759
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80501130
37TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78357545
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77389468
39MYC_18940864_ChIP-ChIP_HL60_Human1.75349191
40* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73529913
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72092772
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.64176343
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63649709
44MYC_22102868_ChIP-Seq_BL_Human1.61338351
45KDM5A_27292631_Chip-Seq_BREAST_Human1.61053499
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53243347
47ZNF263_19887448_ChIP-Seq_K562_Human1.50893384
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.45922720
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44484592
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44397124
51SRF_21415370_ChIP-Seq_HL-1_Mouse1.40717455
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.40186517
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39381687
54* GABP_19822575_ChIP-Seq_HepG2_Human1.34682828
55* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33788382
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.33574943
57TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.32914056
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30275094
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.28782087
60* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28197309
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27017460
62KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26731950
63KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26731950
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26731950
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24723917
66SRY_22984422_ChIP-ChIP_TESTIS_Rat1.23068230
67ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22102264
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21442036
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21006194
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20848543
71BP1_19119308_ChIP-ChIP_Hs578T_Human1.20300603
72IRF1_19129219_ChIP-ChIP_H3396_Human1.18078880
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17590605
74* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14799032
75* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12696371
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.10562753
77NOTCH1_21737748_ChIP-Seq_TLL_Human1.08683170
78AR_21909140_ChIP-Seq_LNCAP_Human1.07610864
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.06851964
80TET1_21451524_ChIP-Seq_MESCs_Mouse1.06634864
81* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06257191
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04451282
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01812830
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01709570
85NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00849997
86TP63_19390658_ChIP-ChIP_HaCaT_Human0.99608876
87BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98456979
88CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96949186
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96515346
90SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93865276
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93659234
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92315444
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92212677
94TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92039253
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89141099
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88690757
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88273497
98* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85824829
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85326317
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.84536479
101STAT1_20625510_ChIP-Seq_HELA_Human0.83740335
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.83688318
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83225276
104SOX2_16153702_ChIP-ChIP_HESCs_Human0.82751821
105P68_20966046_ChIP-Seq_HELA_Human0.82590376
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82543861
107MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81765190
108* SOX17_20123909_ChIP-Seq_XEN_Mouse0.81478691
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81456007
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81039555
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80152601
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.79844826
113CTCF_26484167_Chip-Seq_Bcells_Mouse0.79733074
114SA1_27219007_Chip-Seq_ERYTHROID_Human0.79460040
115* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.79334493
116* SPI1_23547873_ChIP-Seq_NB4_Human0.78818911
117E2F1_21310950_ChIP-Seq_MCF-7_Human0.78695671
118SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.77796335
119MAF_26560356_Chip-Seq_TH2_Human0.77468785
120CIITA_25753668_ChIP-Seq_RAJI_Human0.76605402
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.75413212
122* ELF5_23300383_ChIP-Seq_T47D_Human0.72092406
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.68362377
124VDR_21846776_ChIP-Seq_THP-1_Human0.68334554
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.67786708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.55572974
2MP0003136_yellow_coat_color3.23896753
3MP0003693_abnormal_embryo_hatching3.01526802
4MP0004381_abnormal_hair_follicle2.73525581
5MP0004957_abnormal_blastocyst_morpholog2.38420659
6MP0005174_abnormal_tail_pigmentation2.32700158
7MP0003941_abnormal_skin_development2.26618330
8MP0002277_abnormal_respiratory_mucosa2.18902736
9MP0002938_white_spotting2.01112457
10MP0002163_abnormal_gland_morphology1.92290582
11MP0002132_abnormal_respiratory_system1.90601950
12MP0003315_abnormal_perineum_morphology1.87239862
13MP0008932_abnormal_embryonic_tissue1.80761224
14MP0002102_abnormal_ear_morphology1.73061144
15MP0002796_impaired_skin_barrier1.67614326
16MP0002638_abnormal_pupillary_reflex1.64704330
17MP0003011_delayed_dark_adaptation1.60421137
18MP0003786_premature_aging1.58722204
19MP0002095_abnormal_skin_pigmentation1.57573238
20MP0001346_abnormal_lacrimal_gland1.57246539
21MP0000049_abnormal_middle_ear1.55592669
22MP0005409_darkened_coat_color1.55350040
23MP0001986_abnormal_taste_sensitivity1.54594584
24MP0001293_anophthalmia1.54045048
25MP0010094_abnormal_chromosome_stability1.53954604
26MP0002697_abnormal_eye_size1.52170439
27MP0003077_abnormal_cell_cycle1.50135175
28MP0001188_hyperpigmentation1.42519182
29MP0002282_abnormal_trachea_morphology1.40595808
30MP0006292_abnormal_olfactory_placode1.39187567
31MP0000372_irregular_coat_pigmentation1.36664770
32MP0000762_abnormal_tongue_morphology1.36343874
33MP0008995_early_reproductive_senescence1.35791266
34MP0000490_abnormal_crypts_of1.32871399
35MP0008057_abnormal_DNA_replication1.32066219
36MP0002249_abnormal_larynx_morphology1.31516995
37MP0010030_abnormal_orbit_morphology1.30295915
38MP0005171_absent_coat_pigmentation1.28511773
39MP0005501_abnormal_skin_physiology1.26973186
40MP0002148_abnormal_hypersensitivity_rea1.24960506
41MP0008004_abnormal_stomach_pH1.24385317
42MP0000631_abnormal_neuroendocrine_gland1.21670055
43MP0000566_synostosis1.18251196
44MP0003111_abnormal_nucleus_morphology1.17598837
45MP0006072_abnormal_retinal_apoptosis1.16587806
46MP0003123_paternal_imprinting1.16193836
47MP0002210_abnormal_sex_determination1.15121035
48MP0003938_abnormal_ear_development1.13864049
49MP0008058_abnormal_DNA_repair1.12830403
50MP0005408_hypopigmentation1.11445913
51MP0009053_abnormal_anal_canal1.08535566
52MP0002160_abnormal_reproductive_system1.08512944
53MP0009333_abnormal_splenocyte_physiolog1.07874974
54MP0003890_abnormal_embryonic-extraembry1.07680739
55MP0001873_stomach_inflammation1.06227398
56MP0005075_abnormal_melanosome_morpholog1.06155120
57MP0002751_abnormal_autonomic_nervous1.06062965
58MP0001529_abnormal_vocalization1.04992783
59MP0000613_abnormal_salivary_gland1.04945700
60MP0005379_endocrine/exocrine_gland_phen1.03680721
61MP0002085_abnormal_embryonic_tissue1.01027077
62MP0003724_increased_susceptibility_to1.00136739
63MP0002736_abnormal_nociception_after1.00090570
64MP0003806_abnormal_nucleotide_metabolis0.98814439
65MP0003718_maternal_effect0.98076781
66MP0008789_abnormal_olfactory_epithelium0.97994371
67MP0009250_abnormal_appendicular_skeleto0.97176940
68MP0002098_abnormal_vibrissa_morphology0.96741707
69MP0000313_abnormal_cell_death0.94867353
70MP0008007_abnormal_cellular_replicative0.94358074
71MP0001697_abnormal_embryo_size0.94011511
72MP0003942_abnormal_urinary_system0.93560793
73MP0006276_abnormal_autonomic_nervous0.93152156
74MP0010771_integument_phenotype0.93017515
75MP0003984_embryonic_growth_retardation0.92524153
76MP0002396_abnormal_hematopoietic_system0.92259742
77MP0001672_abnormal_embryogenesis/_devel0.92243098
78MP0005380_embryogenesis_phenotype0.92243098
79MP0003283_abnormal_digestive_organ0.91151730
80MP0002092_abnormal_eye_morphology0.90299507
81MP0008961_abnormal_basal_metabolism0.89656240
82MP0002088_abnormal_embryonic_growth/wei0.89557698
83MP0003567_abnormal_fetal_cardiomyocyte0.89321601
84MP0005394_taste/olfaction_phenotype0.88742895
85MP0005499_abnormal_olfactory_system0.88742895
86MP0002111_abnormal_tail_morphology0.86002960
87MP0003861_abnormal_nervous_system0.83585144
88MP0005083_abnormal_biliary_tract0.83407372
89MP0002084_abnormal_developmental_patter0.83366663
90MP0002080_prenatal_lethality0.82989928
91MP0001145_abnormal_male_reproductive0.82778555
92MP0002177_abnormal_outer_ear0.82586801
93MP0001919_abnormal_reproductive_system0.82535730
94MP0005377_hearing/vestibular/ear_phenot0.82222644
95MP0003878_abnormal_ear_physiology0.82222644
96MP0001905_abnormal_dopamine_level0.81013659
97MP0003763_abnormal_thymus_physiology0.80853524
98MP0002060_abnormal_skin_morphology0.80594380
99MP0001968_abnormal_touch/_nociception0.80364931
100MP0001216_abnormal_epidermal_layer0.80231242
101MP0002653_abnormal_ependyma_morphology0.80125568
102MP0006035_abnormal_mitochondrial_morpho0.79261131
103MP0005389_reproductive_system_phenotype0.78255739
104MP0000778_abnormal_nervous_system0.78210608
105MP0005423_abnormal_somatic_nervous0.77969241
106MP0004185_abnormal_adipocyte_glucose0.75410471
107MP0001727_abnormal_embryo_implantation0.74687104
108MP0001730_embryonic_growth_arrest0.73993405
109MP0002009_preneoplasia0.73458807
110MP0001853_heart_inflammation0.73100758
111MP0003186_abnormal_redox_activity0.72082727
112MP0005367_renal/urinary_system_phenotyp0.71406514
113MP0000516_abnormal_urinary_system0.71406514
114MP0001286_abnormal_eye_development0.71322112
115MP0002234_abnormal_pharynx_morphology0.70883948
116MP0000579_abnormal_nail_morphology0.70261312
117MP0001663_abnormal_digestive_system0.68836000
118MP0005000_abnormal_immune_tolerance0.67100671
119MP0002405_respiratory_system_inflammati0.66997870
120MP0002116_abnormal_craniofacial_bone0.66976892
121MP0000026_abnormal_inner_ear0.66825675
122MP0002006_tumorigenesis0.66362151
123MP0003385_abnormal_body_wall0.66138864
124MP0009785_altered_susceptibility_to0.66113528
125MP0000653_abnormal_sex_gland0.65607407
126MP0000858_altered_metastatic_potential0.65582400
127MP0003959_abnormal_lean_body0.65217437
128MP0005391_vision/eye_phenotype0.64859364
129MP0001348_abnormal_lacrimal_gland0.64476857
130MP0004742_abnormal_vestibular_system0.64427571
131MP0002932_abnormal_joint_morphology0.64331563
132MP0000470_abnormal_stomach_morphology0.64250055
133MP0000703_abnormal_thymus_morphology0.63961871
134MP0002019_abnormal_tumor_incidence0.63746705
135MP0001800_abnormal_humoral_immune0.63439241
136MP0005381_digestive/alimentary_phenotyp0.63211058
137MP0000467_abnormal_esophagus_morphology0.63062797
138MP0000537_abnormal_urethra_morphology0.62726717
139MP0000750_abnormal_muscle_regeneration0.61728665
140MP0001835_abnormal_antigen_presentation0.59828698
141MP0003937_abnormal_limbs/digits/tail_de0.59760888
142MP0005025_abnormal_response_to0.59364110
143MP0000647_abnormal_sebaceous_gland0.58934702
144MP0002166_altered_tumor_susceptibility0.58854166
145MP0004142_abnormal_muscle_tone0.58375217
146MP0000350_abnormal_cell_proliferation0.57750824
147MP0001485_abnormal_pinna_reflex0.56360157
148MP0003755_abnormal_palate_morphology0.56269224

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.55050569
2Reticulocytopenia (HP:0001896)8.92978974
3Abnormal number of erythroid precursors (HP:0012131)8.38708378
4Macrocytic anemia (HP:0001972)7.06173203
5Pallor (HP:0000980)6.44322279
6Abnormal hemoglobin (HP:0011902)4.85401489
7Increased hepatocellular lipid droplets (HP:0006565)4.71265011
8Acute necrotizing encephalopathy (HP:0006965)4.69652337
9Mitochondrial inheritance (HP:0001427)4.51826797
10Abnormal mitochondria in muscle tissue (HP:0008316)4.02525779
11Progressive macrocephaly (HP:0004481)4.01708248
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.99543342
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.93979215
14Lipid accumulation in hepatocytes (HP:0006561)3.91187655
15Renal Fanconi syndrome (HP:0001994)3.77987583
16Hepatocellular necrosis (HP:0001404)3.63544810
17Increased CSF lactate (HP:0002490)3.61290640
18Exertional dyspnea (HP:0002875)3.57753938
19Congenital, generalized hypertrichosis (HP:0004540)3.50780953
20Acute encephalopathy (HP:0006846)3.49155929
21Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.46551114
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37865317
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37865317
24Increased intramyocellular lipid droplets (HP:0012240)3.12582716
25Concave nail (HP:0001598)3.06878258
263-Methylglutaconic aciduria (HP:0003535)3.04450399
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.00659173
28Depressed nasal ridge (HP:0000457)2.95054087
29Respiratory difficulties (HP:0002880)2.94781751
30Rib fusion (HP:0000902)2.94214649
31Birth length less than 3rd percentile (HP:0003561)2.93861727
32Abnormality of the axillary hair (HP:0100134)2.91561090
33Abnormality of secondary sexual hair (HP:0009888)2.91561090
34Hepatic necrosis (HP:0002605)2.86418328
35Stenosis of the external auditory canal (HP:0000402)2.84612308
3611 pairs of ribs (HP:0000878)2.79206295
37Woolly hair (HP:0002224)2.69734072
38Absent thumb (HP:0009777)2.64210834
39Parakeratosis (HP:0001036)2.64126180
40Abnormality of reticulocytes (HP:0004312)2.61124319
41Exercise intolerance (HP:0003546)2.60365537
42Colon cancer (HP:0003003)2.59753072
43Septo-optic dysplasia (HP:0100842)2.56759005
44Triphalangeal thumb (HP:0001199)2.53230820
45Migraine (HP:0002076)2.48506020
46Partial duplication of thumb phalanx (HP:0009944)2.46232178
47Respiratory failure (HP:0002878)2.44818002
48Partial duplication of the phalanx of hand (HP:0009999)2.43288759
49Optic disc pallor (HP:0000543)2.43084745
50Increased muscle lipid content (HP:0009058)2.40222796
51Thrombocytosis (HP:0001894)2.38632673
52Trismus (HP:0000211)2.37261559
53Fragile nails (HP:0001808)2.35838222
54Increased serum lactate (HP:0002151)2.34656980
55Thick lower lip vermilion (HP:0000179)2.32359463
56Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30934631
57Aplastic anemia (HP:0001915)2.30000476
58Chromsome breakage (HP:0040012)2.28740096
59Abnormality of renal resorption (HP:0011038)2.28248376
60Amniotic constriction ring (HP:0009775)2.26323486
61Abnormality of placental membranes (HP:0011409)2.26323486
62Hypoplasia of the radius (HP:0002984)2.24839205
63Congenital ichthyosiform erythroderma (HP:0007431)2.16838418
64Cerebral edema (HP:0002181)2.09825138
65Aplasia cutis congenita (HP:0001057)2.06887291
66Maternal diabetes (HP:0009800)2.06009061
67Leukodystrophy (HP:0002415)2.02238980
68Absent septum pellucidum (HP:0001331)2.01716498
69Oral leukoplakia (HP:0002745)2.00686444
70Bilateral microphthalmos (HP:0007633)2.00313167
71Sparse lateral eyebrow (HP:0005338)1.96784405
72Abnormality of homocysteine metabolism (HP:0010919)1.94339247
73Homocystinuria (HP:0002156)1.94339247
74Glossoptosis (HP:0000162)1.92459916
75Lactic acidosis (HP:0003128)1.90415163
76Aplasia/Hypoplasia of the patella (HP:0006498)1.88996023
77Patellar aplasia (HP:0006443)1.88973760
78Hyperphosphaturia (HP:0003109)1.88842166
79Morphological abnormality of the inner ear (HP:0011390)1.88494269
80Abnormality of cochlea (HP:0000375)1.86317603
81Horseshoe kidney (HP:0000085)1.84487998
82Duplicated collecting system (HP:0000081)1.83998373
83Duplication of thumb phalanx (HP:0009942)1.83889429
84Rough bone trabeculation (HP:0100670)1.83533686
85Asplenia (HP:0001746)1.82847436
86Nasolacrimal duct obstruction (HP:0000579)1.82039075
87Aplasia/hypoplasia of the uterus (HP:0008684)1.81962955
88Hypoplasia of the pons (HP:0012110)1.81442467
89Abnormality of the pons (HP:0007361)1.78885997
90Multiple enchondromatosis (HP:0005701)1.78539919
91Cerebellar dysplasia (HP:0007033)1.76892511
92Abnormality of the septum pellucidum (HP:0007375)1.76153544
93Breast hypoplasia (HP:0003187)1.76023285
94Cleft eyelid (HP:0000625)1.75581655
95Short thumb (HP:0009778)1.75003704
96Ridged nail (HP:0001807)1.73806003
97Progressive muscle weakness (HP:0003323)1.73487825
98Pancytopenia (HP:0001876)1.73304693
99Testicular atrophy (HP:0000029)1.72679430
100Abnormality of the preputium (HP:0100587)1.72485732
101Aplasia/Hypoplasia of the uvula (HP:0010293)1.72469884
102Abnormality of the nasolacrimal system (HP:0000614)1.71716710
103Sparse eyelashes (HP:0000653)1.71551077
104Megaloblastic anemia (HP:0001889)1.68921899
105Abnormality of DNA repair (HP:0003254)1.67933710
106Squamous cell carcinoma (HP:0002860)1.67283589
107Hypoparathyroidism (HP:0000829)1.66694380
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.66587155
109Supernumerary bones of the axial skeleton (HP:0009144)1.65168790
110Abnormality of the renal collecting system (HP:0004742)1.63364538
111Supernumerary ribs (HP:0005815)1.62952242
112Anophthalmia (HP:0000528)1.62439356
113Esophageal atresia (HP:0002032)1.62252458
114Abnormal pupillary function (HP:0007686)1.61033308
115Oligodactyly (hands) (HP:0001180)1.59389103
116Calcaneovalgus deformity (HP:0001848)1.59117542
117Myelodysplasia (HP:0002863)1.58804555
118Down-sloping shoulders (HP:0200021)1.57062732
119Sensory axonal neuropathy (HP:0003390)1.56430845
120Abnormal urine phosphate concentration (HP:0012599)1.56350523
121Abnormality of the parietal bone (HP:0002696)1.54271524
122Meckel diverticulum (HP:0002245)1.54051501
123Missing ribs (HP:0000921)1.53345162
124Secondary amenorrhea (HP:0000869)1.49373155
125Microvesicular hepatic steatosis (HP:0001414)1.48901622
126Short nose (HP:0003196)1.45942887
127Hypotrichosis (HP:0001006)1.45915477
128Atresia of the external auditory canal (HP:0000413)1.45899634
129Popliteal pterygium (HP:0009756)1.45336612
130Absent radius (HP:0003974)1.44677052
131Abnormal number of incisors (HP:0011064)1.43862954
132Abnormal trabecular bone morphology (HP:0100671)1.43044737
133Redundant skin (HP:0001582)1.42387760
134Seborrheic dermatitis (HP:0001051)1.40967612
135Type I transferrin isoform profile (HP:0003642)1.39636710
136Abnormality of the lacrimal duct (HP:0011481)1.39426941
137Forearm undergrowth (HP:0009821)1.39194399

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME26.58833789
2TLK15.61901584
3VRK24.26316794
4STK162.94555366
5PIM22.78075044
6NME12.72891804
7MST42.68621741
8SRPK12.55677959
9VRK12.45904021
10MAP3K102.41767978
11BUB12.29458376
12RPS6KB22.21856444
13LRRK22.04825537
14WEE12.02798943
15EEF2K1.98432311
16MAPK151.81333654
17CDK191.80454752
18PDK21.76725931
19TRIB31.71250562
20PBK1.69906772
21BMPR1B1.65089447
22TGFBR11.59160531
23WNK41.56800126
24NEK11.53998692
25PNCK1.44412137
26EIF2AK11.39927295
27MKNK11.38415255
28SMG11.36552830
29CDK121.34187161
30EPHB21.32791262
31CDK81.32619255
32ILK1.30062321
33TAF11.27498325
34DYRK31.23994912
35BRSK11.18464564
36GRK51.17979553
37AURKB1.15526943
38SIK11.14622019
39CDK41.13470067
40MKNK21.10927555
41CDK71.07688260
42CASK1.05912086
43ATR1.05270046
44MAPKAPK51.00778438
45AURKA1.00095908
46MAP3K120.99913767
47PLK40.98611331
48DYRK20.96713879
49BLK0.95903439
50TEC0.94773709
51GRK70.93846905
52ADRBK20.90961297
53PRPF4B0.90682485
54STK390.90182577
55RPS6KA50.89201001
56MUSK0.89063581
57MST1R0.88548242
58EIF2AK30.88098452
59TYRO30.87403573
60BRSK20.86608265
61CSNK2A20.85987171
62DAPK30.85451670
63IRAK40.85233952
64EIF2AK20.84498841
65MAP2K20.83752905
66MAPKAPK30.82068470
67ICK0.82002120
68TESK20.81984073
69IKBKB0.81022063
70ADRBK10.78127866
71PLK10.77508805
72MYLK0.76449901
73CHEK10.75621316
74CSNK2A10.74496612
75PAK10.73407057
76UHMK10.72013549
77ARAF0.71817372
78LIMK10.71086763
79CLK10.68934733
80CDK30.67916727
81CDK20.67564357
82STK40.66563165
83ABL20.66414851
84IRAK30.65483976
85PIM10.62142947
86MAP3K110.61728222
87PASK0.61232517
88FES0.61029411
89BTK0.57597159
90CDC70.57229882
91CCNB10.56771647
92GRK10.56276459
93IRAK20.54693575
94CDK10.54689245
95TNIK0.52506234
96LATS20.52408354
97KDR0.52149585
98CSNK1E0.51727075
99MAPK40.51449195
100PIK3CG0.50733292
101MAP4K10.50318611
102YES10.49985899
103MOS0.49230151
104PAK20.48432894
105PRKCI0.47730567
106MTOR0.46533972
107BRAF0.44625231
108ACVR1B0.43516544
109MAP3K80.43018383
110RPS6KA10.42768844
111RPS6KC10.42173802
112RPS6KL10.42173802
113CHEK20.42081559
114LYN0.41882461
115RPS6KA40.41765230
116LCK0.40772017
117SIK20.40234510
118NLK0.40022843
119CDK90.39176084
120NUAK10.37812533
121KIT0.37634710
122ROCK20.37365932
123ZAK0.36476929
124STK100.36183222
125AKT10.35925803
126PLK30.35472921
127MAP3K30.35027980
128SYK0.34974711
129MAP2K60.34958296
130NEK20.34931232
131CDK11A0.34266860
132RPS6KA60.34196571
133CAMKK10.33890209
134MARK30.33176947
135IRAK10.32935839
136PTK60.32702041
137DYRK1B0.32341417
138MAPK140.32142028
139TTK0.31360036
140STK240.31047452
141STK110.30714272
142ATM0.30660926
143EPHA20.30226359
144PRKDC0.25417459
145MELK0.24338734
146CAMK1D0.21627460
147AKT20.21233933
148GSK3B0.20165905

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.21757868
2Oxidative phosphorylation_Homo sapiens_hsa001904.11801830
3Parkinsons disease_Homo sapiens_hsa050123.68454530
4RNA polymerase_Homo sapiens_hsa030203.36854082
5Proteasome_Homo sapiens_hsa030503.04731126
6Huntingtons disease_Homo sapiens_hsa050162.82106368
7Alzheimers disease_Homo sapiens_hsa050102.71311524
8Spliceosome_Homo sapiens_hsa030402.46054873
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.37863671
10Protein export_Homo sapiens_hsa030602.36776248
11DNA replication_Homo sapiens_hsa030302.33737226
12Mismatch repair_Homo sapiens_hsa034302.19562978
13Homologous recombination_Homo sapiens_hsa034402.04054087
14Pyrimidine metabolism_Homo sapiens_hsa002402.01240166
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92095066
16Nucleotide excision repair_Homo sapiens_hsa034201.84162960
17Cardiac muscle contraction_Homo sapiens_hsa042601.54685471
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52112709
19Fanconi anemia pathway_Homo sapiens_hsa034601.43531518
20RNA transport_Homo sapiens_hsa030131.40742166
21Base excision repair_Homo sapiens_hsa034101.35013885
22Basal transcription factors_Homo sapiens_hsa030221.28023740
23Non-homologous end-joining_Homo sapiens_hsa034501.16869700
24RNA degradation_Homo sapiens_hsa030181.14653051
25Systemic lupus erythematosus_Homo sapiens_hsa053221.06719025
26Purine metabolism_Homo sapiens_hsa002300.96981851
27One carbon pool by folate_Homo sapiens_hsa006700.87425940
28Sulfur relay system_Homo sapiens_hsa041220.85519531
29Pyruvate metabolism_Homo sapiens_hsa006200.80409674
30Biosynthesis of amino acids_Homo sapiens_hsa012300.78973679
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.76780651
32Arachidonic acid metabolism_Homo sapiens_hsa005900.73140700
33p53 signaling pathway_Homo sapiens_hsa041150.73053799
34Cell cycle_Homo sapiens_hsa041100.71178758
35Epstein-Barr virus infection_Homo sapiens_hsa051690.69118597
36Selenocompound metabolism_Homo sapiens_hsa004500.65593336
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65339840
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65230234
39Cyanoamino acid metabolism_Homo sapiens_hsa004600.64812722
40Graft-versus-host disease_Homo sapiens_hsa053320.63556363
41Primary immunodeficiency_Homo sapiens_hsa053400.62206844
42Vitamin digestion and absorption_Homo sapiens_hsa049770.61126322
43Hematopoietic cell lineage_Homo sapiens_hsa046400.60700758
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59408155
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54188616
46mRNA surveillance pathway_Homo sapiens_hsa030150.53450360
47Glutathione metabolism_Homo sapiens_hsa004800.52867264
48Asthma_Homo sapiens_hsa053100.52281999
49Allograft rejection_Homo sapiens_hsa053300.50796482
50Alcoholism_Homo sapiens_hsa050340.48643565
51Basal cell carcinoma_Homo sapiens_hsa052170.48156941
52Phototransduction_Homo sapiens_hsa047440.47742834
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47379429
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.47054820
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45916198
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43627326
57Folate biosynthesis_Homo sapiens_hsa007900.42965461
58Autoimmune thyroid disease_Homo sapiens_hsa053200.42737008
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.42431878
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42043667
61Herpes simplex infection_Homo sapiens_hsa051680.40316773
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39870587
63Metabolic pathways_Homo sapiens_hsa011000.39298497
64Sphingolipid metabolism_Homo sapiens_hsa006000.39248820
65Linoleic acid metabolism_Homo sapiens_hsa005910.39214191
66Carbon metabolism_Homo sapiens_hsa012000.38448599
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36840406
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36588341
69Antigen processing and presentation_Homo sapiens_hsa046120.36509568
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36389332
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.36358546
72Fructose and mannose metabolism_Homo sapiens_hsa000510.35496672
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35107596
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34520152
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31619501
76N-Glycan biosynthesis_Homo sapiens_hsa005100.31503967
77Arginine biosynthesis_Homo sapiens_hsa002200.30360781
78Hedgehog signaling pathway_Homo sapiens_hsa043400.30168573
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29896605
80Ether lipid metabolism_Homo sapiens_hsa005650.28607445
81Nitrogen metabolism_Homo sapiens_hsa009100.27484195
82Hippo signaling pathway_Homo sapiens_hsa043900.26596060
83Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.25000323
84Bladder cancer_Homo sapiens_hsa052190.22900227
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22428523
86Malaria_Homo sapiens_hsa051440.22260319
87HTLV-I infection_Homo sapiens_hsa051660.21361076
88Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.21207609
89Viral carcinogenesis_Homo sapiens_hsa052030.20865778
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19890198
91Pertussis_Homo sapiens_hsa051330.18971470
92Rheumatoid arthritis_Homo sapiens_hsa053230.18939500
93TGF-beta signaling pathway_Homo sapiens_hsa043500.18719951
94Pathways in cancer_Homo sapiens_hsa052000.18117000
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17639661
96Wnt signaling pathway_Homo sapiens_hsa043100.17415052
97Colorectal cancer_Homo sapiens_hsa052100.16500392
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.16046037
99Thyroid cancer_Homo sapiens_hsa052160.15346120
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.14671560
101ECM-receptor interaction_Homo sapiens_hsa045120.14038716
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.13691071
103Jak-STAT signaling pathway_Homo sapiens_hsa046300.13472228
104Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13236598
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13042745
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12947323
107Vibrio cholerae infection_Homo sapiens_hsa051100.11653921
108Melanoma_Homo sapiens_hsa052180.11643449
109Pentose phosphate pathway_Homo sapiens_hsa000300.11228623
110Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10789549
111Small cell lung cancer_Homo sapiens_hsa052220.10584099
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10425158
113Legionellosis_Homo sapiens_hsa051340.09867461
114Measles_Homo sapiens_hsa051620.09689256
115Lysine degradation_Homo sapiens_hsa003100.09642407
116Notch signaling pathway_Homo sapiens_hsa043300.08260312
117Leishmaniasis_Homo sapiens_hsa051400.07599353
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.07526588
119Tyrosine metabolism_Homo sapiens_hsa003500.07489155
120Apoptosis_Homo sapiens_hsa042100.07489020
121MicroRNAs in cancer_Homo sapiens_hsa052060.07412098
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.07143245
123Melanogenesis_Homo sapiens_hsa049160.06726684
124Fatty acid elongation_Homo sapiens_hsa000620.06549578
125Fat digestion and absorption_Homo sapiens_hsa049750.06313944
126Serotonergic synapse_Homo sapiens_hsa047260.05719363
127Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.04688342
128Central carbon metabolism in cancer_Homo sapiens_hsa052300.04554444
129Non-small cell lung cancer_Homo sapiens_hsa052230.04069611
130HIF-1 signaling pathway_Homo sapiens_hsa040660.03617608
131Chronic myeloid leukemia_Homo sapiens_hsa052200.03567224
132Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01747634
133Renal cell carcinoma_Homo sapiens_hsa052110.00675699
134Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010-0.0301042
135Phenylalanine metabolism_Homo sapiens_hsa00360-0.0064720

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