RPL37A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.22955169
2* viral transcription (GO:0019083)8.81319156
3* translational termination (GO:0006415)8.47311455
4ribosomal small subunit biogenesis (GO:0042274)7.69423547
5* translational elongation (GO:0006414)7.34158359
6* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.27173945
7* protein targeting to ER (GO:0045047)7.09962480
8* cotranslational protein targeting to membrane (GO:0006613)7.09752900
9mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.97103050
10maturation of SSU-rRNA (GO:0030490)6.94633832
11* establishment of protein localization to endoplasmic reticulum (GO:0072599)6.76319665
12* protein localization to endoplasmic reticulum (GO:0070972)6.63232119
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.59607171
14* cellular protein complex disassembly (GO:0043624)6.55215021
15* viral life cycle (GO:0019058)6.53151909
16ATP synthesis coupled proton transport (GO:0015986)6.49963457
17energy coupled proton transport, down electrochemical gradient (GO:0015985)6.49963457
18* translational initiation (GO:0006413)6.37844271
19ribosomal large subunit biogenesis (GO:0042273)6.07810178
20* protein complex disassembly (GO:0043241)5.76978807
21* macromolecular complex disassembly (GO:0032984)5.41731894
22establishment of protein localization to mitochondrial membrane (GO:0090151)5.28060786
23DNA deamination (GO:0045006)5.11785669
24chaperone-mediated protein transport (GO:0072321)5.09190587
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.94389925
26respiratory electron transport chain (GO:0022904)4.92365661
27electron transport chain (GO:0022900)4.81957014
28* nuclear-transcribed mRNA catabolic process (GO:0000956)4.80972816
29ribonucleoprotein complex biogenesis (GO:0022613)4.72944567
30* translation (GO:0006412)4.71790314
31* protein targeting to membrane (GO:0006612)4.66089162
32* mRNA catabolic process (GO:0006402)4.56221523
33* RNA catabolic process (GO:0006401)4.29173868
34formation of translation preinitiation complex (GO:0001731)4.06244699
35telomere maintenance via semi-conservative replication (GO:0032201)3.91258658
36DNA strand elongation involved in DNA replication (GO:0006271)3.86387811
37rRNA processing (GO:0006364)3.81196634
38* protein localization to membrane (GO:0072657)3.81118997
39mitochondrial respiratory chain complex I assembly (GO:0032981)3.79387470
40NADH dehydrogenase complex assembly (GO:0010257)3.79387470
41mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.79387470
42protein complex biogenesis (GO:0070271)3.72905825
43DNA strand elongation (GO:0022616)3.68055342
44rRNA metabolic process (GO:0016072)3.66998098
45protein neddylation (GO:0045116)3.58544538
46cellular component biogenesis (GO:0044085)3.56728799
47ATP biosynthetic process (GO:0006754)3.54887746
48mitochondrial respiratory chain complex assembly (GO:0033108)3.53726790
49spliceosomal snRNP assembly (GO:0000387)3.45594077
50telomere maintenance via recombination (GO:0000722)3.38319749
51spliceosomal complex assembly (GO:0000245)3.36206656
52purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.35900332
53sequestering of actin monomers (GO:0042989)3.31165836
54ncRNA 3-end processing (GO:0043628)3.30649067
55DNA replication initiation (GO:0006270)3.30509655
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.29248747
57regulation of mitochondrial translation (GO:0070129)3.19903397
58pseudouridine synthesis (GO:0001522)3.19350081
59inner mitochondrial membrane organization (GO:0007007)3.18634411
60deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16773305
61mitotic recombination (GO:0006312)3.15871703
62* establishment of protein localization to membrane (GO:0090150)3.15413965
63ribosome biogenesis (GO:0042254)3.15317614
64DNA replication checkpoint (GO:0000076)3.12903502
65ribonucleoside triphosphate biosynthetic process (GO:0009201)3.12301379
66DNA unwinding involved in DNA replication (GO:0006268)3.11403376
67* protein localization to organelle (GO:0033365)3.09927030
68folic acid-containing compound biosynthetic process (GO:0009396)3.09362354
69telomere maintenance via telomere lengthening (GO:0010833)3.08795541
70hydrogen ion transmembrane transport (GO:1902600)3.08429305
71proteasome assembly (GO:0043248)3.05355961
72nucleotide-excision repair, DNA gap filling (GO:0006297)3.00173378
73* establishment of protein localization to organelle (GO:0072594)2.98947859
74* protein targeting (GO:0006605)2.95811073
75intracellular protein transmembrane import (GO:0044743)2.94210954
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.93818289
77termination of RNA polymerase III transcription (GO:0006386)2.93818289
78chromatin remodeling at centromere (GO:0031055)2.92447484
79CENP-A containing nucleosome assembly (GO:0034080)2.89571136
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86252898
81nucleobase biosynthetic process (GO:0046112)2.80083205
82transcription-coupled nucleotide-excision repair (GO:0006283)2.78147831
83GTP biosynthetic process (GO:0006183)2.75773518
84ribosome assembly (GO:0042255)2.75677800
85positive regulation of gastrulation (GO:2000543)2.71413313
86negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.70475840
87negative regulation of RNA splicing (GO:0033119)2.69612051
88protein localization to kinetochore (GO:0034501)2.69508177
89ncRNA processing (GO:0034470)2.69342464
90nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68632368
91rRNA modification (GO:0000154)2.68511251
92kinetochore organization (GO:0051383)2.68429011
93IMP biosynthetic process (GO:0006188)2.68135842
94nucleoside triphosphate biosynthetic process (GO:0009142)2.67900645
95DNA replication-dependent nucleosome organization (GO:0034723)2.67570801
96DNA replication-dependent nucleosome assembly (GO:0006335)2.67570801
97establishment of protein localization to mitochondrion (GO:0072655)2.67449862
98behavioral response to nicotine (GO:0035095)2.67280861
99protein targeting to mitochondrion (GO:0006626)2.65983331
100UTP biosynthetic process (GO:0006228)2.64423581
101mitotic metaphase plate congression (GO:0007080)2.63619026
102kinetochore assembly (GO:0051382)2.63438945
103establishment of integrated proviral latency (GO:0075713)2.63280269
104neuron fate determination (GO:0048664)2.58839483
105mitotic nuclear envelope disassembly (GO:0007077)2.57982557
106proton transport (GO:0015992)2.57978367
107regulation of protein heterodimerization activity (GO:0043497)2.57121222
108purine nucleobase biosynthetic process (GO:0009113)2.57017333
109pteridine-containing compound biosynthetic process (GO:0042559)2.56905336
110histone mRNA metabolic process (GO:0008334)2.56897180
111DNA damage response, detection of DNA damage (GO:0042769)2.56727353
112viral mRNA export from host cell nucleus (GO:0046784)2.56603628
113* gene expression (GO:0010467)2.55101228
114DNA replication-independent nucleosome assembly (GO:0006336)2.53976573
115DNA replication-independent nucleosome organization (GO:0034724)2.53976573
116anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52785683
117positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.52686216
118ncRNA metabolic process (GO:0034660)2.52664811
119protein localization to mitochondrion (GO:0070585)2.52481732
120ribonucleoprotein complex assembly (GO:0022618)2.52210372
121regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.52124921
122hydrogen transport (GO:0006818)2.51760156
123heterochromatin organization (GO:0070828)2.50039388
124termination of RNA polymerase II transcription (GO:0006369)2.49682087
125RNA splicing, via transesterification reactions (GO:0000375)2.49265252
126RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.48800838
127mRNA splicing, via spliceosome (GO:0000398)2.48800838
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.48549376
129negative regulation of ligase activity (GO:0051352)2.48226788
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.48226788
131oxidative phosphorylation (GO:0006119)2.48165557
132protein localization to chromosome, centromeric region (GO:0071459)2.45520635
133protein-cofactor linkage (GO:0018065)2.43714289
134purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.43062656
135purine nucleoside monophosphate biosynthetic process (GO:0009127)2.43062656
136DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.41509873
137pyrimidine nucleotide catabolic process (GO:0006244)2.41451656
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.40721362
139UTP metabolic process (GO:0046051)2.40672417
140intra-S DNA damage checkpoint (GO:0031573)2.39181440
141antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.39124029
142* cellular component disassembly (GO:0022411)2.38887723
143ribonucleoprotein complex subunit organization (GO:0071826)2.38698318
144DNA-templated transcription, termination (GO:0006353)2.38479709
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.37578687
146midbrain development (GO:0030901)2.34565584
147mitochondrial transport (GO:0006839)2.34556311
148positive regulation of respiratory burst (GO:0060267)2.33575873
149protein transmembrane transport (GO:0071806)2.32607511
150pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.31996655
151intracellular protein transmembrane transport (GO:0065002)2.31393903
152otic vesicle formation (GO:0030916)2.28815187
153CTP metabolic process (GO:0046036)2.27936383
154CTP biosynthetic process (GO:0006241)2.27936383
155aerobic respiration (GO:0009060)2.23962997
156cell proliferation in forebrain (GO:0021846)2.22546930
157pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.22396825

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.29864669
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.48349375
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.98545275
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22990297
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13181548
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.02543344
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.95606218
8EZH2_22144423_ChIP-Seq_EOC_Human2.93146261
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.90993408
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87138511
11FOXM1_23109430_ChIP-Seq_U2OS_Human2.85576569
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80268706
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76172036
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.69998289
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68623318
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64240413
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.62246936
18* XRN2_22483619_ChIP-Seq_HELA_Human2.61178504
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49259760
20* VDR_23849224_ChIP-Seq_CD4+_Human2.21543090
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19430329
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17302493
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15267365
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.11148498
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09837642
26* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.08940091
27DCP1A_22483619_ChIP-Seq_HELA_Human2.04050402
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02677053
29* TTF2_22483619_ChIP-Seq_HELA_Human1.99737602
30FOXP3_21729870_ChIP-Seq_TREG_Human1.94201987
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.86761820
32* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82281562
33GABP_19822575_ChIP-Seq_HepG2_Human1.73057638
34* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72667429
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.72562281
36* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72325316
37MYC_22102868_ChIP-Seq_BL_Human1.70082999
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.68475426
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61509084
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.59480604
41CIITA_25753668_ChIP-Seq_RAJI_Human1.57963061
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.57149529
43EZH2_27304074_Chip-Seq_ESCs_Mouse1.56695423
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53192624
45VDR_21846776_ChIP-Seq_THP-1_Human1.51040277
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50964443
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50905189
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.50306546
49POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49851136
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.48241077
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.47107793
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47078853
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.47055348
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46450776
55* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45579012
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.43304008
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41863318
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.41396301
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.40972651
60MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39347498
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38147261
62CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35791217
63TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35790979
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35429512
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34665310
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.33751696
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.33229514
68TP63_17297297_ChIP-ChIP_HaCaT_Human1.32968113
69STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32903922
70KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30840894
71* SRF_21415370_ChIP-Seq_HL-1_Mouse1.30260476
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29482968
73CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28346486
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28309230
75KDM5A_27292631_Chip-Seq_BREAST_Human1.23380745
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.23363317
77EED_16625203_ChIP-ChIP_MESCs_Mouse1.21409381
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20768300
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20512123
80* SPI1_23547873_ChIP-Seq_NB4_Human1.19741526
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18973139
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17591350
83* ELK1_22589737_ChIP-Seq_MCF10A_Human1.17225642
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.16896582
85AR_21909140_ChIP-Seq_LNCAP_Human1.16784350
86NOTCH1_21737748_ChIP-Seq_TLL_Human1.16394561
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.14369949
88IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14329976
89FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.10806304
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10093703
91SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.09569218
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09381800
93SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09357434
94KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09129061
95CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08222887
96MYC_18940864_ChIP-ChIP_HL60_Human1.08107697
97FOXP1_21924763_ChIP-Seq_HESCs_Human1.06842277
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04927172
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.04314599
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03422286
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02935982
102* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02717842
103HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.02053814
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00220955
105SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99648109
106TFEB_21752829_ChIP-Seq_HELA_Human0.99178727
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97562581
108RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97427245
109SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.96992404
110JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96837986
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96716364
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96528688
113PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.95325343
114IRF8_22096565_ChIP-ChIP_GC-B_Human0.94581542
115MAF_26560356_Chip-Seq_TH2_Human0.94268956
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.93340218
117EZH2_27294783_Chip-Seq_ESCs_Mouse0.92541814
118RNF2_27304074_Chip-Seq_NSC_Mouse0.91758422
119* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91567296
120RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90808186
121EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90808186
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90421620
123STAT4_19710469_ChIP-ChIP_TH1__Mouse0.89250468
124UTX_26944678_Chip-Seq_JUKART_Human0.88772254
125MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88726818
126MAF_26560356_Chip-Seq_TH1_Human0.88559692
127NANOG_16153702_ChIP-ChIP_HESCs_Human0.88344736
128* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88152104
129SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.87948305
130FUS_26573619_Chip-Seq_HEK293_Human0.86481242
131* TET1_21451524_ChIP-Seq_MESCs_Mouse0.86354452
132SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85890648
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85821945
134CTCF_27219007_Chip-Seq_Bcells_Human0.78157620
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77913111
136EWS_26573619_Chip-Seq_HEK293_Human0.77559337
137IRF1_19129219_ChIP-ChIP_H3396_Human0.76988190
138* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.76198818
139GATA1_26923725_Chip-Seq_HPCs_Mouse0.75833851
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.75667012
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75147366

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.37777646
2MP0006292_abnormal_olfactory_placode4.33115984
3MP0009379_abnormal_foot_pigmentation4.16850303
4MP0003136_yellow_coat_color3.66629949
5MP0004957_abnormal_blastocyst_morpholog3.57268191
6MP0003111_abnormal_nucleus_morphology3.06486084
7MP0003077_abnormal_cell_cycle3.06279850
8MP0010094_abnormal_chromosome_stability3.03171921
9MP0000566_synostosis3.02770094
10MP0008058_abnormal_DNA_repair2.33424355
11MP0008007_abnormal_cellular_replicative2.32139634
12MP0002396_abnormal_hematopoietic_system2.27159179
13MP0000490_abnormal_crypts_of2.13207657
14MP0008932_abnormal_embryonic_tissue2.08963628
15MP0003122_maternal_imprinting1.97584603
16MP0008789_abnormal_olfactory_epithelium1.96124046
17MP0008057_abnormal_DNA_replication1.94653438
18MP0009333_abnormal_splenocyte_physiolog1.92298891
19MP0003763_abnormal_thymus_physiology1.89653037
20MP0005394_taste/olfaction_phenotype1.79998933
21MP0005499_abnormal_olfactory_system1.79998933
22MP0002653_abnormal_ependyma_morphology1.76145087
23MP0003123_paternal_imprinting1.74544789
24MP0004808_abnormal_hematopoietic_stem1.73563426
25MP0010352_gastrointestinal_tract_polyps1.69453226
26MP0001529_abnormal_vocalization1.65999811
27MP0000350_abnormal_cell_proliferation1.64915960
28MP0001835_abnormal_antigen_presentation1.62361266
29MP0003938_abnormal_ear_development1.62092575
30MP0002132_abnormal_respiratory_system1.58276754
31MP0004142_abnormal_muscle_tone1.54548413
32MP0006054_spinal_hemorrhage1.52956324
33MP0001730_embryonic_growth_arrest1.52563645
34MP0000631_abnormal_neuroendocrine_gland1.52507562
35MP0003890_abnormal_embryonic-extraembry1.51381321
36MP0000537_abnormal_urethra_morphology1.50537454
37MP0000685_abnormal_immune_system1.49045779
38MP0005174_abnormal_tail_pigmentation1.48995610
39MP0000778_abnormal_nervous_system1.48847326
40MP0003121_genomic_imprinting1.47229956
41MP0002234_abnormal_pharynx_morphology1.45889707
42MP0005397_hematopoietic_system_phenotyp1.45567902
43MP0001545_abnormal_hematopoietic_system1.45567902
44MP0002398_abnormal_bone_marrow1.45404657
45MP0003786_premature_aging1.45047693
46MP0001286_abnormal_eye_development1.44033247
47MP0002638_abnormal_pupillary_reflex1.43224700
48MP0002019_abnormal_tumor_incidence1.40651117
49MP0000703_abnormal_thymus_morphology1.40393548
50MP0002697_abnormal_eye_size1.39618987
51MP0002722_abnormal_immune_system1.39530651
52MP0001346_abnormal_lacrimal_gland1.38699358
53MP0003283_abnormal_digestive_organ1.38371245
54MP0000313_abnormal_cell_death1.37746476
55MP0003880_abnormal_central_pattern1.37212384
56MP0000858_altered_metastatic_potential1.35806196
57MP0002163_abnormal_gland_morphology1.35457037
58MP0001485_abnormal_pinna_reflex1.33343847
59MP0006072_abnormal_retinal_apoptosis1.31611927
60MP0008995_early_reproductive_senescence1.29904094
61MP0000689_abnormal_spleen_morphology1.29779238
62MP0001800_abnormal_humoral_immune1.28121857
63MP0003937_abnormal_limbs/digits/tail_de1.27672462
64MP0003186_abnormal_redox_activity1.25646909
65MP0005671_abnormal_response_to1.25146224
66MP0005377_hearing/vestibular/ear_phenot1.24641515
67MP0003878_abnormal_ear_physiology1.24641515
68MP0010155_abnormal_intestine_physiology1.23777549
69MP0003436_decreased_susceptibility_to1.22412763
70MP0003315_abnormal_perineum_morphology1.21957515
71MP0002429_abnormal_blood_cell1.21287904
72MP0003942_abnormal_urinary_system1.19892270
73MP0002160_abnormal_reproductive_system1.19759467
74MP0001697_abnormal_embryo_size1.19239308
75MP0002452_abnormal_antigen_presenting1.18194386
76MP0001853_heart_inflammation1.17624921
77MP0002420_abnormal_adaptive_immunity1.17409556
78MP0000716_abnormal_immune_system1.16718288
79MP0002080_prenatal_lethality1.16312641
80MP0001819_abnormal_immune_cell1.16065820
81MP0003941_abnormal_skin_development1.15456972
82MP0001873_stomach_inflammation1.15053990
83MP0009785_altered_susceptibility_to1.14128921
84MP0002405_respiratory_system_inflammati1.13033992
85MP0010030_abnormal_orbit_morphology1.12979929
86MP0000026_abnormal_inner_ear1.12307741
87MP0004742_abnormal_vestibular_system1.11800001
88MP0002233_abnormal_nose_morphology1.11578273
89MP0005423_abnormal_somatic_nervous1.11383841
90MP0005025_abnormal_response_to1.10675722
91MP0009250_abnormal_appendicular_skeleto1.10362907
92MP0002166_altered_tumor_susceptibility1.07922185
93MP0002249_abnormal_larynx_morphology1.07537232
94MP0002723_abnormal_immune_serum1.06206378
95MP0003567_abnormal_fetal_cardiomyocyte1.06003101
96MP0005380_embryogenesis_phenotype1.05360022
97MP0001672_abnormal_embryogenesis/_devel1.05360022
98MP0005000_abnormal_immune_tolerance1.04763323
99MP0002148_abnormal_hypersensitivity_rea1.02717345
100MP0000372_irregular_coat_pigmentation1.02631321
101MP0004145_abnormal_muscle_electrophysio1.01397470
102MP0006276_abnormal_autonomic_nervous1.01365075
103MP0002095_abnormal_skin_pigmentation0.99624792
104MP0003806_abnormal_nucleotide_metabolis0.99363354
105MP0005075_abnormal_melanosome_morpholog0.98140582
106MP0002006_tumorigenesis0.97831680
107MP0002085_abnormal_embryonic_tissue0.97419267
108MP0003755_abnormal_palate_morphology0.97063406
109MP0002092_abnormal_eye_morphology0.96874419
110MP0005023_abnormal_wound_healing0.96216640
111MP0002822_catalepsy0.94629920
112MP0003011_delayed_dark_adaptation0.94601240
113MP0005195_abnormal_posterior_eye0.94500275
114MP0003861_abnormal_nervous_system0.94472444
115MP0002086_abnormal_extraembryonic_tissu0.94292541
116MP0000465_gastrointestinal_hemorrhage0.93977561
117MP0002752_abnormal_somatic_nervous0.93760475
118MP0002277_abnormal_respiratory_mucosa0.93746409
119MP0003984_embryonic_growth_retardation0.93173881
120MP0000955_abnormal_spinal_cord0.93160307
121MP0002088_abnormal_embryonic_growth/wei0.92013554
122MP0003866_abnormal_defecation0.91972179
123MP0003718_maternal_effect0.91889353
124MP0002184_abnormal_innervation0.91161729
125MP0010307_abnormal_tumor_latency0.90966772
126MP0000477_abnormal_intestine_morphology0.90811704
127MP0005391_vision/eye_phenotype0.89959865
128MP0009278_abnormal_bone_marrow0.89546335
129MP0004133_heterotaxia0.88710110
130MP0001188_hyperpigmentation0.88624882
131MP0000762_abnormal_tongue_morphology0.88474979
132MP0004885_abnormal_endolymph0.87500815
133MP0005084_abnormal_gallbladder_morpholo0.87162446
134MP0009053_abnormal_anal_canal0.84322123
135MP0005408_hypopigmentation0.84053422
136MP0002084_abnormal_developmental_patter0.83363710
137MP0001905_abnormal_dopamine_level0.83284924
138MP0003787_abnormal_imprinting0.82811244
139MP0005389_reproductive_system_phenotype0.82088876
140MP0001790_abnormal_immune_system0.81724004
141MP0005387_immune_system_phenotype0.81724004
142MP0004197_abnormal_fetal_growth/weight/0.80665903
143MP0003119_abnormal_digestive_system0.79855456
144MP0000358_abnormal_cell_content/0.79102547
145MP0000613_abnormal_salivary_gland0.79092099
146MP0002557_abnormal_social/conspecific_i0.78715334
147MP0002116_abnormal_craniofacial_bone0.78348051
148MP0001293_anophthalmia0.77330049
149MP0000534_abnormal_ureter_morphology0.74878469
150MP0005187_abnormal_penis_morphology0.74876475
151MP0002932_abnormal_joint_morphology0.74235174
152MP0001845_abnormal_inflammatory_respons0.73900656
153MP0002938_white_spotting0.73778417
154MP0001919_abnormal_reproductive_system0.73157578
155MP0005501_abnormal_skin_physiology0.71287315
156MP0000049_abnormal_middle_ear0.71205486
157MP0005551_abnormal_eye_electrophysiolog0.70866420
158MP0003448_altered_tumor_morphology0.70223248
159MP0005076_abnormal_cell_differentiation0.69528384
160MP0002152_abnormal_brain_morphology0.68794973
161MP0002111_abnormal_tail_morphology0.68585984
162MP0003385_abnormal_body_wall0.67766599
163MP0002837_dystrophic_cardiac_calcinosis0.67482877
164MP0005220_abnormal_exocrine_pancreas0.67326632
165MP0001324_abnormal_eye_pigmentation0.67243277
166MP0002282_abnormal_trachea_morphology0.66227706
167MP0002751_abnormal_autonomic_nervous0.66064787
168MP0001663_abnormal_digestive_system0.65811885
169MP0000678_abnormal_parathyroid_gland0.65650328
170MP0001145_abnormal_male_reproductive0.65176392
171MP0002736_abnormal_nociception_after0.64722323
172MP0002210_abnormal_sex_determination0.64678345
173MP0001299_abnormal_eye_distance/0.64383659
174MP0002419_abnormal_innate_immunity0.64283794
175MP0001963_abnormal_hearing_physiology0.63093149
176MP0005646_abnormal_pituitary_gland0.62590516

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)7.91876267
2Abnormality of cells of the erythroid lineage (HP:0012130)7.50242950
3Abnormal number of erythroid precursors (HP:0012131)6.94179756
4Macrocytic anemia (HP:0001972)5.63171756
5Pallor (HP:0000980)5.38999214
6Aplasia/Hypoplasia of the sacrum (HP:0008517)4.30093728
7Acute encephalopathy (HP:0006846)4.02487173
8Thrombocytosis (HP:0001894)3.97456245
9Colon cancer (HP:0003003)3.90775559
10Septo-optic dysplasia (HP:0100842)3.87624333
11Progressive macrocephaly (HP:0004481)3.73091988
12Partial duplication of thumb phalanx (HP:0009944)3.61391552
13Aplastic anemia (HP:0001915)3.58835145
14Abnormal hemoglobin (HP:0011902)3.56552161
15Oral leukoplakia (HP:0002745)3.48565523
1611 pairs of ribs (HP:0000878)3.33382269
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05362355
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05362355
19Trismus (HP:0000211)2.97759153
20Cerebral edema (HP:0002181)2.90996918
21Absent thumb (HP:0009777)2.81758986
22Rib fusion (HP:0000902)2.79109654
23Rough bone trabeculation (HP:0100670)2.72332912
24Increased hepatocellular lipid droplets (HP:0006565)2.69866117
25Maternal diabetes (HP:0009800)2.67391749
26Abnormality of reticulocytes (HP:0004312)2.66499007
27Multiple enchondromatosis (HP:0005701)2.60882355
28Birth length less than 3rd percentile (HP:0003561)2.60229025
29Myokymia (HP:0002411)2.57889097
30Breast hypoplasia (HP:0003187)2.56984058
31Exertional dyspnea (HP:0002875)2.56264076
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.55759919
33Hepatocellular necrosis (HP:0001404)2.55468839
34Selective tooth agenesis (HP:0001592)2.53598920
35Microretrognathia (HP:0000308)2.52578715
36Abnormality of the parietal bone (HP:0002696)2.49305028
37Absent septum pellucidum (HP:0001331)2.48542351
38Duplication of thumb phalanx (HP:0009942)2.38750980
39Concave nail (HP:0001598)2.37224019
40Lipid accumulation in hepatocytes (HP:0006561)2.37082325
41Depressed nasal ridge (HP:0000457)2.37027251
42Mitochondrial inheritance (HP:0001427)2.33669633
43IgM deficiency (HP:0002850)2.32343944
44Triphalangeal thumb (HP:0001199)2.29091681
45Esophageal atresia (HP:0002032)2.28255636
46Anophthalmia (HP:0000528)2.27929779
47Optic disc pallor (HP:0000543)2.26254806
48Premature graying of hair (HP:0002216)2.24825947
49Abnormality of renal resorption (HP:0011038)2.23352397
50Hepatic necrosis (HP:0002605)2.22375552
51Carpal bone hypoplasia (HP:0001498)2.21598117
52Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.20858817
53Neoplasm of the pancreas (HP:0002894)2.20056499
54Exercise intolerance (HP:0003546)2.19015044
55Leukodystrophy (HP:0002415)2.18541025
56Myelodysplasia (HP:0002863)2.14011257
57Missing ribs (HP:0000921)2.12748135
58Hypoplasia of the radius (HP:0002984)2.12457221
59Aplasia/Hypoplasia of the patella (HP:0006498)2.10061639
60Meckel diverticulum (HP:0002245)2.09949097
61Patellar aplasia (HP:0006443)2.09632456
62Pancytopenia (HP:0001876)2.09562041
63Lactic acidosis (HP:0003128)2.09133218
64Increased serum lactate (HP:0002151)2.08969195
65Abnormality of the preputium (HP:0100587)2.08545198
66Respiratory failure (HP:0002878)2.07537488
67Bilateral microphthalmos (HP:0007633)2.03896492
68Abnormality of the septum pellucidum (HP:0007375)2.02949086
69Type I transferrin isoform profile (HP:0003642)2.02679146
70Thick lower lip vermilion (HP:0000179)2.02158391
71Cleft eyelid (HP:0000625)2.00959401
72Increased CSF lactate (HP:0002490)2.00496172
73Increased intramyocellular lipid droplets (HP:0012240)1.99625937
74Degeneration of anterior horn cells (HP:0002398)1.98053545
75Abnormality of the anterior horn cell (HP:0006802)1.98053545
76Hyperphosphaturia (HP:0003109)1.97212205
77Abnormality of the ileum (HP:0001549)1.97198164
78Molar tooth sign on MRI (HP:0002419)1.96907430
79Abnormality of midbrain morphology (HP:0002418)1.96907430
80Hyperglycinemia (HP:0002154)1.95091643
81Horseshoe kidney (HP:0000085)1.93037525
82Poikiloderma (HP:0001029)1.92766945
83Premature ovarian failure (HP:0008209)1.92281371
84Asplenia (HP:0001746)1.91675621
85Pancreatic fibrosis (HP:0100732)1.91378552
86Lymphoma (HP:0002665)1.90428988
87Abnormal trabecular bone morphology (HP:0100671)1.89628110
88Chromsome breakage (HP:0040012)1.89150894
89Tracheoesophageal fistula (HP:0002575)1.88685179
90Cellular immunodeficiency (HP:0005374)1.87851958
91Migraine (HP:0002076)1.87823988
92Congenital, generalized hypertrichosis (HP:0004540)1.86129408
93Petechiae (HP:0000967)1.85426850
94Secondary amenorrhea (HP:0000869)1.85151169
95Abnormality of urine glucose concentration (HP:0011016)1.83131760
96Glycosuria (HP:0003076)1.83131760
97Poor head control (HP:0002421)1.80661410
98Pancreatic cysts (HP:0001737)1.80631130
99Renal Fanconi syndrome (HP:0001994)1.79858049
100Basal cell carcinoma (HP:0002671)1.78990458
101Bone marrow hypocellularity (HP:0005528)1.78602501
102Aplasia/Hypoplasia of the spleen (HP:0010451)1.77909570
103Abnormality of T cell physiology (HP:0011840)1.76575563
104Nasolacrimal duct obstruction (HP:0000579)1.75473922
105Optic nerve hypoplasia (HP:0000609)1.75363150
106Progressive muscle weakness (HP:0003323)1.75336116
107Elevated erythrocyte sedimentation rate (HP:0003565)1.74924398
108Glossoptosis (HP:0000162)1.73874880
109Microvesicular hepatic steatosis (HP:0001414)1.73839054
110Acute necrotizing encephalopathy (HP:0006965)1.73375505
111Respiratory difficulties (HP:0002880)1.72959712
1123-Methylglutaconic aciduria (HP:0003535)1.72435902
113Atresia of the external auditory canal (HP:0000413)1.71648198
114Increased muscle lipid content (HP:0009058)1.71083699
115Abnormality of chromosome stability (HP:0003220)1.69898990
116Abdominal situs inversus (HP:0003363)1.69053853
117Abnormality of abdominal situs (HP:0011620)1.69053853
118Stenosis of the external auditory canal (HP:0000402)1.69004736
119Forearm undergrowth (HP:0009821)1.68708555
120Abnormality of the 4th metacarpal (HP:0010012)1.68236464
121Abnormality of the labia minora (HP:0012880)1.67893783
122Pulmonary fibrosis (HP:0002206)1.67187802
123Abnormality of T cells (HP:0002843)1.66574498
124Broad distal phalanx of finger (HP:0009836)1.66099328
125Abnormality of the phalanges of the 2nd finger (HP:0009541)1.65637761
126Partial duplication of the phalanx of hand (HP:0009999)1.65189066
127Abnormality of the heme biosynthetic pathway (HP:0010472)1.65130819
128Sclerocornea (HP:0000647)1.64866019
129Neoplasm of the colon (HP:0100273)1.64068626
130Abnormality of the lacrimal duct (HP:0011481)1.63659964
131Sparse eyelashes (HP:0000653)1.63654764
132Agnosia (HP:0010524)1.62829974
133Abnormal mitochondria in muscle tissue (HP:0008316)1.62824553
134Granulocytopenia (HP:0001913)1.61547767
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.60456295
136Woolly hair (HP:0002224)1.60231433
137Hypoplasia of the pons (HP:0012110)1.59719334
138Abnormal number of incisors (HP:0011064)1.59459559
139Abnormal urine phosphate concentration (HP:0012599)1.58247805
140Aplasia/Hypoplasia of the uvula (HP:0010293)1.57950625
141Chromosomal breakage induced by crosslinking agents (HP:0003221)1.57885154
142Acute lymphatic leukemia (HP:0006721)1.57553816
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.56344817
144Abnormality of the diencephalon (HP:0010662)1.53319453
145Anencephaly (HP:0002323)1.52650085
146Hypoplasia of the ulna (HP:0003022)1.51967418
147Type II lissencephaly (HP:0007260)1.51312417
148Abnormal ciliary motility (HP:0012262)1.51149795
149Humeroradial synostosis (HP:0003041)1.50767778
150Synostosis involving the elbow (HP:0003938)1.50767778
151Abnormality of the nasolacrimal system (HP:0000614)1.50180841
152Abnormality of the pons (HP:0007361)1.50098537
153Abnormal respiratory motile cilium physiology (HP:0012261)1.49949948
154Morphological abnormality of the inner ear (HP:0011390)1.49572229
155Supernumerary spleens (HP:0009799)1.49302835

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK15.03590447
2NME24.56799187
3VRK24.04888106
4BUB13.44112620
5WEE12.99440273
6EPHB22.74716034
7EIF2AK12.59811368
8DYRK22.59624122
9RPS6KB22.27304626
10SRPK12.21627144
11TESK22.14254527
12CDC72.07492087
13VRK12.06439344
14LRRK22.01808016
15STK161.96484328
16PNCK1.94522483
17NEK21.93024139
18MAP4K11.84538331
19MAPK151.82030268
20PIM21.81021825
21RPS6KA41.62896225
22TAF11.61395328
23PASK1.58262786
24DYRK31.57365319
25WNK41.49377883
26EEF2K1.49358570
27TGFBR11.47217014
28AURKB1.43338712
29PLK41.39365818
30FLT31.36606267
31CDK71.34761740
32PLK11.34730450
33MAP3K101.32587766
34IRAK31.31610481
35BRSK21.28523357
36TYRO31.28214319
37MAP3K111.26798545
38KDR1.25169590
39BLK1.24788542
40PAK41.23887129
41EIF2AK31.21667521
42ILK1.21276966
43STK101.20955425
44SCYL21.18772422
45ACVR1B1.18703854
46MAPKAPK31.18226509
47TESK11.17044604
48MAP3K81.14165741
49CASK1.13895809
50PKN21.13062609
51EPHA21.09233770
52TTK1.08965278
53ATR1.06352344
54PIM11.05483572
55ZAK1.04455776
56MKNK11.01889323
57CDK191.01197163
58NTRK20.98944397
59NME10.98404434
60TSSK60.97067196
61BTK0.94161912
62AURKA0.93311754
63TEC0.92569332
64ZAP700.90726055
65IRAK40.89998768
66PRKCG0.89949118
67MAP2K70.88718876
68DAPK30.88309096
69STK40.88201583
70CDK40.85947397
71WNK30.83916468
72PIK3CA0.83819147
73EPHA40.81582190
74GRK10.80267128
75TNIK0.79600874
76IKBKB0.79513137
77PBK0.79000898
78BCKDK0.77480368
79FGFR20.77306379
80CSNK1E0.76806666
81ADRBK20.74999594
82RPS6KA50.74757324
83TYK20.74511324
84JAK30.73879980
85CHEK20.72870722
86MST40.72741007
87MKNK20.72240722
88NUAK10.71019390
89NEK90.69328878
90ABL20.68046470
91MAP3K40.67895036
92PINK10.67149101
93CDK30.66910384
94NEK10.66509129
95CSNK2A20.64525326
96CAMK10.64301736
97KIT0.63639635
98GRK60.63101072
99MAP3K90.62772640
100TBK10.62391066
101PAK10.61932086
102MAP2K30.61762430
103CAMKK10.61671182
104MAP2K20.61499125
105BMPR1B0.59684703
106MAP2K40.59303349
107PRKCI0.59303047
108CDK80.59260261
109CSNK2A10.58963979
110INSRR0.58091155
111CHEK10.58009958
112MUSK0.57360890
113STK240.56403684
114MARK10.54432618
115PIK3CG0.54398787
116RPS6KA60.53795734
117CCNB10.52104395
118TXK0.50805618
119UHMK10.50495728
120NLK0.49791733
121ARAF0.48666906
122BRSK10.47613285
123OBSCN0.47454460
124STK110.46418148
125PDK20.46285251
126CDK11A0.46143723
127ADRBK10.46072204
128EIF2AK20.45118487
129CDK20.44826954
130TRIB30.44747987
131SGK2230.42967182
132SGK4940.42967182
133LYN0.42736380
134ATM0.42618800
135RPS6KC10.42129065
136RPS6KL10.42129065
137PLK30.42074566
138MINK10.41863941
139PRKACA0.41604231
140IKBKE0.41029396
141CSF1R0.40092818
142ERN10.39090200
143BRAF0.38303214
144MAP2K60.38026403
145DYRK1B0.36302561
146CDK60.35296975
147TGFBR20.35056841
148SYK0.34805227
149DYRK1A0.34181180
150LCK0.33738899
151RPS6KA10.33366922

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030107.00636659
2DNA replication_Homo sapiens_hsa030304.17742464
3Mismatch repair_Homo sapiens_hsa034303.51522292
4RNA polymerase_Homo sapiens_hsa030203.12490258
5Proteasome_Homo sapiens_hsa030503.01093065
6Spliceosome_Homo sapiens_hsa030403.00378001
7Cardiac muscle contraction_Homo sapiens_hsa042602.87422610
8Homologous recombination_Homo sapiens_hsa034402.71847102
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.68294403
10Base excision repair_Homo sapiens_hsa034102.58999313
11Pyrimidine metabolism_Homo sapiens_hsa002402.41570745
12Nucleotide excision repair_Homo sapiens_hsa034202.36526013
13RNA transport_Homo sapiens_hsa030132.20633645
14One carbon pool by folate_Homo sapiens_hsa006702.20033779
15Fanconi anemia pathway_Homo sapiens_hsa034601.76173657
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.75193579
17Cell cycle_Homo sapiens_hsa041101.73111515
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65630447
19Protein export_Homo sapiens_hsa030601.57563494
20RNA degradation_Homo sapiens_hsa030181.50379056
21Sulfur relay system_Homo sapiens_hsa041221.46801701
22Parkinsons disease_Homo sapiens_hsa050121.45777756
23Non-homologous end-joining_Homo sapiens_hsa034501.44599622
24Systemic lupus erythematosus_Homo sapiens_hsa053221.41722699
25p53 signaling pathway_Homo sapiens_hsa041151.40877345
26Oxidative phosphorylation_Homo sapiens_hsa001901.35993471
27Huntingtons disease_Homo sapiens_hsa050161.25411925
28Basal transcription factors_Homo sapiens_hsa030221.21275641
29Folate biosynthesis_Homo sapiens_hsa007901.15369972
30Antigen processing and presentation_Homo sapiens_hsa046121.11343535
31Purine metabolism_Homo sapiens_hsa002301.10727379
32Primary immunodeficiency_Homo sapiens_hsa053401.08889551
33Epstein-Barr virus infection_Homo sapiens_hsa051691.04543849
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01960476
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99638558
36Herpes simplex infection_Homo sapiens_hsa051680.99326452
37mRNA surveillance pathway_Homo sapiens_hsa030150.97805024
38Pentose phosphate pathway_Homo sapiens_hsa000300.87028017
39Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.86928449
40Hedgehog signaling pathway_Homo sapiens_hsa043400.86621409
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78131871
42Viral carcinogenesis_Homo sapiens_hsa052030.76305251
43Alzheimers disease_Homo sapiens_hsa050100.75167523
44Legionellosis_Homo sapiens_hsa051340.72221503
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.69791725
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69713409
47HTLV-I infection_Homo sapiens_hsa051660.66346480
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.63485410
49Hematopoietic cell lineage_Homo sapiens_hsa046400.63014531
50Phototransduction_Homo sapiens_hsa047440.62991210
51Measles_Homo sapiens_hsa051620.62896935
52Intestinal immune network for IgA production_Homo sapiens_hsa046720.60638328
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60296681
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59338883
55Glutathione metabolism_Homo sapiens_hsa004800.58671298
56Pyruvate metabolism_Homo sapiens_hsa006200.57607765
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57055719
58Apoptosis_Homo sapiens_hsa042100.56554757
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55396933
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54833599
61Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54537073
62Thyroid cancer_Homo sapiens_hsa052160.53310936
63N-Glycan biosynthesis_Homo sapiens_hsa005100.52355363
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.52169178
65Selenocompound metabolism_Homo sapiens_hsa004500.51732596
66Vitamin digestion and absorption_Homo sapiens_hsa049770.50762910
67Other glycan degradation_Homo sapiens_hsa005110.50635080
68Small cell lung cancer_Homo sapiens_hsa052220.50542905
69Nicotine addiction_Homo sapiens_hsa050330.49987285
70Leishmaniasis_Homo sapiens_hsa051400.49636148
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.48288966
72Linoleic acid metabolism_Homo sapiens_hsa005910.47379909
73Acute myeloid leukemia_Homo sapiens_hsa052210.46954741
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46808174
75Bladder cancer_Homo sapiens_hsa052190.45595627
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.44580178
77Wnt signaling pathway_Homo sapiens_hsa043100.44372631
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41907630
79Fat digestion and absorption_Homo sapiens_hsa049750.41598296
80Alcoholism_Homo sapiens_hsa050340.41066528
81Shigellosis_Homo sapiens_hsa051310.41017984
82Hepatitis B_Homo sapiens_hsa051610.40750148
83Hippo signaling pathway_Homo sapiens_hsa043900.40633608
84Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40255868
85Peroxisome_Homo sapiens_hsa041460.40025293
86Allograft rejection_Homo sapiens_hsa053300.37587111
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.36822396
88Nitrogen metabolism_Homo sapiens_hsa009100.36034378
89Tyrosine metabolism_Homo sapiens_hsa003500.35698545
90Influenza A_Homo sapiens_hsa051640.35053000
91Biosynthesis of amino acids_Homo sapiens_hsa012300.34350723
92Galactose metabolism_Homo sapiens_hsa000520.33793105
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33790750
94Asthma_Homo sapiens_hsa053100.33681506
95Notch signaling pathway_Homo sapiens_hsa043300.32761390
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.32309852
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.32110337
98B cell receptor signaling pathway_Homo sapiens_hsa046620.31912771
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31696217
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31307848
101Basal cell carcinoma_Homo sapiens_hsa052170.29325843
102Arachidonic acid metabolism_Homo sapiens_hsa005900.29041670
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.28522512
104MicroRNAs in cancer_Homo sapiens_hsa052060.27887328
105Chronic myeloid leukemia_Homo sapiens_hsa052200.27415124
106Graft-versus-host disease_Homo sapiens_hsa053320.26834809
107Axon guidance_Homo sapiens_hsa043600.26348820
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26001275
109Butanoate metabolism_Homo sapiens_hsa006500.25440617
110Metabolic pathways_Homo sapiens_hsa011000.25145768
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.25124635
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25059435
113Arginine and proline metabolism_Homo sapiens_hsa003300.24165045
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23798662
115HIF-1 signaling pathway_Homo sapiens_hsa040660.23225633
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23026414
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.22162162
118Steroid biosynthesis_Homo sapiens_hsa001000.21980814
119Tryptophan metabolism_Homo sapiens_hsa003800.21602468
120Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21582421
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.21552499
122Propanoate metabolism_Homo sapiens_hsa006400.21422762
123Collecting duct acid secretion_Homo sapiens_hsa049660.20846183
124Chemical carcinogenesis_Homo sapiens_hsa052040.20815155
125Pertussis_Homo sapiens_hsa051330.20806049
126Pathways in cancer_Homo sapiens_hsa052000.19397903
127Oocyte meiosis_Homo sapiens_hsa041140.18875576
128Olfactory transduction_Homo sapiens_hsa047400.18634309
129T cell receptor signaling pathway_Homo sapiens_hsa046600.18303585
130TGF-beta signaling pathway_Homo sapiens_hsa043500.18184921
131Toxoplasmosis_Homo sapiens_hsa051450.17855444
132Fructose and mannose metabolism_Homo sapiens_hsa000510.17532449
133Melanogenesis_Homo sapiens_hsa049160.16720748
134Carbon metabolism_Homo sapiens_hsa012000.16621268
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.16397976
136Retinol metabolism_Homo sapiens_hsa008300.15573082
137Cocaine addiction_Homo sapiens_hsa050300.15326246
138Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.13950419
139Taste transduction_Homo sapiens_hsa047420.13840129
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13036720
141Phenylalanine metabolism_Homo sapiens_hsa003600.12696911
142Caffeine metabolism_Homo sapiens_hsa002320.12296885
143Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.11476474
144Steroid hormone biosynthesis_Homo sapiens_hsa001400.09675479
145Morphine addiction_Homo sapiens_hsa050320.06827253
146Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.04759296
147Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03461678
148Melanoma_Homo sapiens_hsa052180.02006681
149Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0028945

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