RPL37AP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of activation of Janus kinase activity (GO:0010533)9.37926611
2positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)9.26272300
3cellular anion homeostasis (GO:0030002)8.04328223
4positive regulation of cell fate commitment (GO:0010455)7.98076583
5positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)7.90723078
6regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)7.19104865
7positive regulation of activated T cell proliferation (GO:0042104)7.05766859
8positive regulation of interleukin-17 production (GO:0032740)6.73191760
9regulation of B cell receptor signaling pathway (GO:0050855)6.60496549
10cellular response to gamma radiation (GO:0071480)5.96462028
11regulation of memory T cell differentiation (GO:0043380)5.94312357
12regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.67791891
13cell migration involved in gastrulation (GO:0042074)5.58158126
14secondary heart field specification (GO:0003139)5.26289927
15heart field specification (GO:0003128)5.26289927
16cell migration involved in heart development (GO:0060973)5.15777400
17DNA deamination (GO:0045006)5.08826719
18negative regulation of cell fate specification (GO:0009996)5.04857170
19regulation of activated T cell proliferation (GO:0046006)4.88267752
20regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.85231095
21positive regulation of defense response to virus by host (GO:0002230)4.76064400
22ribosomal small subunit biogenesis (GO:0042274)4.70144814
23positive regulation of fibroblast migration (GO:0010763)4.62978134
24oxaloacetate metabolic process (GO:0006107)4.60826029
25morphogenesis of an endothelium (GO:0003159)4.54703158
26endothelial tube morphogenesis (GO:0061154)4.54703158
27regulation of mesoderm development (GO:2000380)4.51853244
28positive regulation of endothelial cell apoptotic process (GO:2000353)4.50712530
29regulation of endothelial cell chemotaxis (GO:2001026)4.49201757
30L-fucose catabolic process (GO:0042355)4.48403776
31fucose catabolic process (GO:0019317)4.48403776
32L-fucose metabolic process (GO:0042354)4.48403776
33viral transcription (GO:0019083)4.48172145
34positive regulation of alpha-beta T cell proliferation (GO:0046641)4.36351523
35cardiac ventricle formation (GO:0003211)4.36006593
36growth hormone receptor signaling pathway (GO:0060396)4.35013961
37translational termination (GO:0006415)4.26693770
38nucleoside transmembrane transport (GO:1901642)4.26127527
39magnesium ion transport (GO:0015693)4.21168589
40opsonization (GO:0008228)4.19783701
41cardiac chamber formation (GO:0003207)4.02910703
42cellular response to growth hormone stimulus (GO:0071378)3.92437340
43behavioral response to nicotine (GO:0035095)3.87571101
44positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.83334881
45positive regulation of CREB transcription factor activity (GO:0032793)3.75403740
46regulation of histone H3-K27 methylation (GO:0061085)3.75157871
47positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.73787831
48maturation of SSU-rRNA (GO:0030490)3.73439863
49cytidine deamination (GO:0009972)3.66364037
50cytidine metabolic process (GO:0046087)3.66364037
51cytidine catabolic process (GO:0006216)3.66364037
52negative regulation of cell fate commitment (GO:0010454)3.63894978
53positive regulation of macrophage cytokine production (GO:0060907)3.61923614
54specification of organ identity (GO:0010092)3.60778721
55regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.60424705
56male genitalia development (GO:0030539)3.56773706
57positive regulation of natural killer cell mediated immunity (GO:0002717)3.56230989
58C4-dicarboxylate transport (GO:0015740)3.53892178
59regulation of chronic inflammatory response (GO:0002676)3.53559401
60regulation of cell fate commitment (GO:0010453)3.51924064
61regulation of interleukin-17 production (GO:0032660)3.51661855
62hydrogen peroxide biosynthetic process (GO:0050665)3.45860372
63translational elongation (GO:0006414)3.45826372
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.42149742
65signal transduction involved in regulation of gene expression (GO:0023019)3.40406596
66negative regulation of interleukin-10 production (GO:0032693)3.38383525
67regulation of alpha-beta T cell proliferation (GO:0046640)3.34974658
68sleep (GO:0030431)3.34119711
69glycosphingolipid biosynthetic process (GO:0006688)3.29122884
70SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.27879084
71positive regulation of T-helper 1 type immune response (GO:0002827)3.24330287
72cellular protein complex disassembly (GO:0043624)3.21936666
73positive regulation of keratinocyte differentiation (GO:0045618)3.21139363
74cotranslational protein targeting to membrane (GO:0006613)3.19383014
75viral life cycle (GO:0019058)3.17723836
76positive regulation of natural killer cell activation (GO:0032816)3.16500226
77positive regulation of T cell apoptotic process (GO:0070234)3.14735502
78regulation of histone deacetylation (GO:0031063)3.14707747
79protein targeting to ER (GO:0045047)3.14427165
80reactive oxygen species biosynthetic process (GO:1903409)3.13903872
81positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.13404078
82cellular response to prostaglandin stimulus (GO:0071379)3.13145523
83primary amino compound metabolic process (GO:1901160)3.08397620
84necroptotic process (GO:0070266)3.06112077
85pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04892159
86regulation of cell fate specification (GO:0042659)3.04680357
87pyrimidine ribonucleoside catabolic process (GO:0046133)3.03447184
88positive regulation of osteoclast differentiation (GO:0045672)3.02258033
89macrophage chemotaxis (GO:0048246)3.02078892
90regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.99482465
91establishment of protein localization to endoplasmic reticulum (GO:0072599)2.97222489
92ganglioside metabolic process (GO:0001573)2.97124615
93positive regulation of DNA biosynthetic process (GO:2000573)2.93399263
94positive regulation of tissue remodeling (GO:0034105)2.93324730
95positive regulation of NF-kappaB import into nucleus (GO:0042346)2.89236912
96protein localization to endoplasmic reticulum (GO:0070972)2.87063887
97regulation of natural killer cell mediated immunity (GO:0002715)2.81863106
98regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.81863106
99cullin deneddylation (GO:0010388)11.0807169
100protein deneddylation (GO:0000338)10.6075545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse7.85286921
2EZH2_22144423_ChIP-Seq_EOC_Human3.64934747
3GBX2_23144817_ChIP-Seq_PC3_Human2.85039112
4VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.70179671
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.47426738
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.43764556
7CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.43043189
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23980976
9TAF2_19829295_ChIP-Seq_ESCs_Human2.23489172
10GATA1_26923725_Chip-Seq_HPCs_Mouse2.21086636
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15194843
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.12269781
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09662407
14RNF2_27304074_Chip-Seq_NSC_Mouse2.00100106
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97006838
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.92566319
17ZNF274_21170338_ChIP-Seq_K562_Hela1.90222723
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.89362828
19E2F1_20622854_ChIP-Seq_HELA_Human1.86925977
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.82978538
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.78554429
22BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78387384
23SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78209983
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.74581011
25TDRD3_21172665_ChIP-Seq_MCF-7_Human1.73276889
26TP53_16413492_ChIP-PET_HCT116_Human1.67881181
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67735971
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67735971
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.65523390
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.63375869
31NANOG_20526341_ChIP-Seq_ESCs_Human1.59609198
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.57083752
33SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.53167939
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53124084
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.52909105
36EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.51793017
37SA1_27219007_Chip-Seq_Bcells_Human1.51363585
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.48673322
39DROSHA_22980978_ChIP-Seq_HELA_Human1.46444709
40EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45279474
41TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.39010941
42CTCF_20526341_ChIP-Seq_ESCs_Human1.38368557
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.36237548
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.34434416
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34418298
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34160724
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.30441866
48YY1_22570637_ChIP-Seq_MALME-3M_Human1.29723742
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29136647
50P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29058756
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.28978811
52VDR_22108803_ChIP-Seq_LS180_Human1.27723473
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25213638
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.25168738
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25095957
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.24348846
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.23906675
58REST_21632747_ChIP-Seq_MESCs_Mouse1.22797897
59NCOR_22424771_ChIP-Seq_293T_Human1.22523654
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.21953504
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.20121217
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20089415
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.19843891
64ERG_20517297_ChIP-Seq_VCAP_Human1.19294445
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18373094
66GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18149151
67RUNX_20019798_ChIP-Seq_JUKART_Human1.17098933
68PHF8_20622854_ChIP-Seq_HELA_Human1.14811333
69FOXA1_25329375_ChIP-Seq_VCAP_Human1.13508659
70FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13508659
71ERA_21632823_ChIP-Seq_H3396_Human1.12034422
72CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.11842174
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.10977976
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.10738896
75KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10618487
76CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10237427
77ERG_21242973_ChIP-ChIP_JURKAT_Human1.10162536
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09469706
79TP53_18474530_ChIP-ChIP_U2OS_Human1.09255611
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09176521
81CTCF_27219007_Chip-Seq_Bcells_Human1.09113524
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07765482
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07690584
84EWS_26573619_Chip-Seq_HEK293_Human1.07370670
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06353309
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.06284663
87EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05972774
88P300_19829295_ChIP-Seq_ESCs_Human1.05192636
89MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04182679
90HTT_18923047_ChIP-ChIP_STHdh_Human1.01721136
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01644925
92MYC_19829295_ChIP-Seq_ESCs_Human1.00841397
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00679096
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.00180874
95TAF15_26573619_Chip-Seq_HEK293_Human0.97573689
96OCT4_20526341_ChIP-Seq_ESCs_Human0.97562283
97RXRA_24833708_ChIP-Seq_LIVER_Mouse0.97468389
98DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95930224
99RAC3_21632823_ChIP-Seq_H3396_Human0.94817913
100FOXH1_21741376_ChIP-Seq_ESCs_Human0.94439657

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002234_abnormal_pharynx_morphology5.51534357
2MP0008875_abnormal_xenobiotic_pharmacok4.35068064
3MP0003690_abnormal_glial_cell4.25556630
4MP0002876_abnormal_thyroid_physiology4.09243539
5MP0004130_abnormal_muscle_cell3.46312766
6MP0005360_urolithiasis3.37495663
7MP0001873_stomach_inflammation3.29080473
8MP0006082_CNS_inflammation3.17858675
9MP0003300_gastrointestinal_ulcer2.92819533
10MP0005671_abnormal_response_to2.61488276
11MP0000678_abnormal_parathyroid_gland2.47030145
12MP0009785_altered_susceptibility_to1.97411122
13MP0000465_gastrointestinal_hemorrhage1.89334873
14MP0008872_abnormal_physiological_respon1.86999551
15MP0006292_abnormal_olfactory_placode1.84452809
16MP0003075_altered_response_to1.74727965
17MP0004510_myositis1.71393947
18MP0009765_abnormal_xenobiotic_induced1.57180458
19MP0003646_muscle_fatigue1.55038913
20MP0001800_abnormal_humoral_immune1.54411503
21MP0002160_abnormal_reproductive_system1.54144211
22MP0010386_abnormal_urinary_bladder1.51849189
23MP0009384_cardiac_valve_regurgitation1.43186745
24MP0000343_altered_response_to1.43162148
25MP0009046_muscle_twitch1.34808519
26MP0005025_abnormal_response_to1.33221901
27MP0001984_abnormal_olfaction1.29464838
28MP0005646_abnormal_pituitary_gland1.29429439
29MP0003879_abnormal_hair_cell1.29085901
30MP0004264_abnormal_extraembryonic_tissu1.29021910
31MP0006072_abnormal_retinal_apoptosis1.28358318
32MP0001663_abnormal_digestive_system1.27430815
33MP0002837_dystrophic_cardiac_calcinosis1.27154779
34MP0003638_abnormal_response/metabolism_1.19439308
35MP0005389_reproductive_system_phenotype1.17212988
36MP0002933_joint_inflammation1.17050102
37MP0005085_abnormal_gallbladder_physiolo1.15539021
38MP0002638_abnormal_pupillary_reflex1.14956497
39MP0003303_peritoneal_inflammation1.13913836
40MP0004885_abnormal_endolymph1.13228989
41MP0001765_abnormal_ion_homeostasis1.11571875
42MP0000230_abnormal_systemic_arterial1.10759047
43MP0008775_abnormal_heart_ventricle1.10095515
44MP0005000_abnormal_immune_tolerance1.09966698
45MP0009780_abnormal_chondrocyte_physiolo1.08332266
46MP0002452_abnormal_antigen_presenting1.07995720
47MP0005166_decreased_susceptibility_to1.05894342
48MP0003136_yellow_coat_color1.04641931
49MP0009333_abnormal_splenocyte_physiolog1.02281708
50MP0005645_abnormal_hypothalamus_physiol1.01852596
51MP0003436_decreased_susceptibility_to0.97995010
52MP0004142_abnormal_muscle_tone0.97909626
53MP0005636_abnormal_mineral_homeostasis0.96994004
54MP0002419_abnormal_innate_immunity0.94681229
55MP0002102_abnormal_ear_morphology0.94622401
56MP0005620_abnormal_muscle_contractility0.94264585
57MP0004145_abnormal_muscle_electrophysio0.93871388
58MP0005332_abnormal_amino_acid0.93479599
59MP0000049_abnormal_middle_ear0.93409532
60MP0002557_abnormal_social/conspecific_i0.92490887
61MP0002723_abnormal_immune_serum0.92468674
62MP0002733_abnormal_thermal_nociception0.91841363
63MP0002177_abnormal_outer_ear0.90701431
64MP0000631_abnormal_neuroendocrine_gland0.90459298
65MP0003567_abnormal_fetal_cardiomyocyte0.89049514
66MP0002148_abnormal_hypersensitivity_rea0.86964285
67MP0001790_abnormal_immune_system0.86360713
68MP0005387_immune_system_phenotype0.86360713
69MP0006276_abnormal_autonomic_nervous0.86219088
70MP0005164_abnormal_response_to0.85431617
71MP0005381_digestive/alimentary_phenotyp0.84184547
72MP0001501_abnormal_sleep_pattern0.84114885
73MP0003878_abnormal_ear_physiology0.82611936
74MP0005377_hearing/vestibular/ear_phenot0.82611936
75MP0001970_abnormal_pain_threshold0.81262936
76MP0002822_catalepsy0.80653882
77MP0009745_abnormal_behavioral_response0.80290311
78MP0005423_abnormal_somatic_nervous0.76479116
79MP0001986_abnormal_taste_sensitivity0.75514361
80MP0000604_amyloidosis0.75397043
81MP0005595_abnormal_vascular_smooth0.75306247
82MP0008004_abnormal_stomach_pH0.74550554
83MP0009764_decreased_sensitivity_to0.73801270
84MP0002420_abnormal_adaptive_immunity0.73340391
85MP0001819_abnormal_immune_cell0.71190108
86MP0001905_abnormal_dopamine_level0.70611813
87MP0002572_abnormal_emotion/affect_behav0.70385417
88MP0010155_abnormal_intestine_physiology0.70120211
89MP0003252_abnormal_bile_duct0.70046804
90MP0004742_abnormal_vestibular_system0.70010604
91MP0002972_abnormal_cardiac_muscle0.69100505
92MP0000538_abnormal_urinary_bladder0.68753634
93MP0002736_abnormal_nociception_after0.68554351
94MP0004019_abnormal_vitamin_homeostasis0.68356171
95MP0002735_abnormal_chemical_nociception0.67831931
96MP0005464_abnormal_platelet_physiology0.66377793
97MP0001835_abnormal_antigen_presentation0.66302468
98MP0000579_abnormal_nail_morphology0.66299321
99MP0001968_abnormal_touch/_nociception0.65855343
100MP0003880_abnormal_central_pattern0.65588511

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune thrombocytopenia (HP:0001973)7.47029167
2Increased IgM level (HP:0003496)6.44450133
3Autoimmune hemolytic anemia (HP:0001890)6.40123599
4Enlarged epiphyses (HP:0010580)5.74901838
5Abnormal delayed hypersensitivity skin test (HP:0002963)5.40990631
6Abnormality of the columella (HP:0009929)4.87452906
7Birth length less than 3rd percentile (HP:0003561)4.85598292
8Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.76543063
9Depressed nasal tip (HP:0000437)4.66734186
10Neonatal hypoglycemia (HP:0001998)4.51792131
11Lip pit (HP:0100267)4.31462023
12Hypochromic anemia (HP:0001931)4.19182531
13Anterior segment dysgenesis (HP:0007700)4.10048963
14Fragile nails (HP:0001808)4.09208858
15Chin dimple (HP:0010751)4.04049551
16Decreased subcutaneous fat (HP:0001002)4.02624026
17Eosinophilia (HP:0001880)3.85507028
18Epileptic encephalopathy (HP:0200134)3.69126913
19Agammaglobulinemia (HP:0004432)3.63467642
20Abnormality of T cell number (HP:0011839)3.63185610
21Global brain atrophy (HP:0002283)3.49536192
22Decreased activity of mitochondrial respiratory chain (HP:0008972)3.46812311
23Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.46812311
24Abnormality of cells of the lymphoid lineage (HP:0012140)3.38974039
25Myotonia (HP:0002486)3.37404737
26Erythroderma (HP:0001019)3.25178445
27Gastrointestinal stroma tumor (HP:0100723)3.23738568
28Thyroid-stimulating hormone excess (HP:0002925)3.15819245
29Sparse lateral eyebrow (HP:0005338)3.11889802
30Hemiplegia (HP:0002301)3.04132176
31Abnormality of eosinophils (HP:0001879)2.93739765
32Vasculitis (HP:0002633)2.91923464
33Abnormality of subcutaneous fat tissue (HP:0001001)2.88074832
34Congenital ichthyosiform erythroderma (HP:0007431)2.86768340
35Granulocytopenia (HP:0001913)2.86115052
36Insulin-resistant diabetes mellitus (HP:0000831)2.77136425
37Cortical visual impairment (HP:0100704)2.77003883
38Premature skin wrinkling (HP:0100678)2.76646488
39Conjugated hyperbilirubinemia (HP:0002908)2.73999191
40Abnormality of the neuromuscular junction (HP:0003398)2.73955859
41Fatigable weakness (HP:0003473)2.73955859
42Abnormality of the fingertips (HP:0001211)2.66458132
43Leukocytosis (HP:0001974)2.64875098
44Hyperthyroidism (HP:0000836)2.64804902
45Glucose intolerance (HP:0000833)2.56602531
46Long palpebral fissure (HP:0000637)2.55948269
47Brittle hair (HP:0002299)2.51924229
48Status epilepticus (HP:0002133)2.50586545
49Hypoplasia of the iris (HP:0007676)2.46667693
50Cupped ear (HP:0000378)2.33739133
51Orchitis (HP:0100796)2.30839908
52Abnormality of T cell physiology (HP:0011840)2.30247682
53Rectal prolapse (HP:0002035)2.28785437
54Hyperglycemia (HP:0003074)2.18293227
55IgG deficiency (HP:0004315)2.17658295
56Macrocytic anemia (HP:0001972)2.17654661
57Hypergammaglobulinemia (HP:0010702)2.15542511
58Generalized tonic-clonic seizures (HP:0002069)2.14552819
59Delayed epiphyseal ossification (HP:0002663)2.12616297
60Neutropenia (HP:0001875)2.08218974
61Congenital stationary night blindness (HP:0007642)2.06702342
62Congenital sensorineural hearing impairment (HP:0008527)2.06346307
63Lower limb hyperreflexia (HP:0002395)2.06087865
64Urticaria (HP:0001025)2.06048449
65Medial flaring of the eyebrow (HP:0010747)2.02483654
66Lymphopenia (HP:0001888)1.99002825
67Abnormality of T cells (HP:0002843)1.96212841
68Pallor (HP:0000980)1.95304362
69Type 2 muscle fiber atrophy (HP:0003554)1.95211198
70Abnormality of macular pigmentation (HP:0008002)1.95163525
71Cutaneous finger syndactyly (HP:0010554)1.92846180
72Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89537708
73Stomatitis (HP:0010280)1.88780979
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.86314786
75Abnormality of alanine metabolism (HP:0010916)1.86314786
76Hyperalaninemia (HP:0003348)1.86314786
77Absent speech (HP:0001344)1.83800395
78Myositis (HP:0100614)1.81896633
79Retrobulbar optic neuritis (HP:0100654)1.79308588
80Optic neuritis (HP:0100653)1.79308588
81Hypocalcemia (HP:0002901)1.74895327
82Oligodontia (HP:0000677)1.72323716
83Protruding ear (HP:0000411)1.72243592
84Emphysema (HP:0002097)1.72028992
85Irritability (HP:0000737)1.71164721
86Mediastinal lymphadenopathy (HP:0100721)1.70252595
87Meningitis (HP:0001287)1.68008696
88Mesomelia (HP:0003027)1.67264911
89Cutaneous syndactyly (HP:0012725)1.62536016
90Muscle fiber atrophy (HP:0100295)1.61082874
91Ectropion (HP:0000656)1.57682727
92Breast aplasia (HP:0100783)1.55857601
93Abnormality of the pupil (HP:0000615)1.54364235
94Abnormal glucose tolerance (HP:0001952)1.53059590
95Facial shape deformation (HP:0011334)1.51734524
96Potter facies (HP:0002009)1.51734524
97Abnormal albumin level (HP:0012116)1.51703244
98Hypoalbuminemia (HP:0003073)1.51703244
99Asplenia (HP:0001746)1.51595345
100Widely patent fontanelles and sutures (HP:0004492)1.50336625

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.28864892
2PIK3CA7.01601119
3ERN13.59657803
4CDK193.28096331
5NUAK13.25107899
6VRK23.14310815
7PRKD22.88981385
8MAP3K132.47478472
9PRKCH2.42154097
10TESK22.26500997
11ADRBK22.17039347
12OXSR11.69588476
13GRK71.68560865
14MOS1.57736036
15CAMK1D1.44565115
16KIT1.42548868
17PRKCG1.42178946
18ADRBK11.41912658
19ICK1.37171068
20CAMKK21.31015680
21TESK11.25078116
22MAPK121.24285054
23RET1.16964055
24MAP3K61.16065671
25BMPR21.04219787
26MAP2K61.03489660
27VRK10.96299188
28MUSK0.88886313
29MAP4K20.88301725
30PRKD10.86961092
31JAK30.84014539
32GRK50.83343439
33LIMK10.83282607
34STK110.82934721
35TGFBR20.77799092
36PRKCE0.76770626
37PTK20.76419700
38ITK0.74696662
39TXK0.70323121
40INSRR0.67878575
41GRK60.67508634
42GRK10.67390167
43CAMK1G0.65757874
44WNK30.64350526
45ERBB20.60659399
46OBSCN0.58827635
47PRKCZ0.56994494
48MAP2K30.55164161
49PDK10.54976421
50IKBKB0.49807102
51LCK0.48994546
52TIE10.48840277
53UHMK10.47874646
54PDGFRB0.47763227
55PRKCI0.46564685
56FRK0.45907634
57STK100.45624529
58INSR0.42133975
59MAP3K90.42009748
60ARAF0.41554806
61SYK0.41119560
62BRAF0.41052442
63PRKACG0.40264834
64MAP2K40.39747109
65WNK40.38462937
66PAK30.38141179
67MATK0.37331662
68STK30.37197981
69PRKACA0.37136289
70PRKG10.36677725
71PRKCA0.36487886
72MARK30.35775206
73CHEK10.34042084
74NTRK20.33328485
75JAK20.33246989
76EPHA40.33009075
77PDPK10.32433459
78IGF1R0.31661887
79TEC0.31491355
80PRKAA10.31032870
81ZAK0.30588855
82PRKCD0.29317652
83PRKAA20.28969708
84MINK10.28465007
85CAMKK10.27357512
86PRKCB0.27077792
87MAPK150.26821165
88CAMK2A0.25592537
89CAMK10.25376631
90FYN0.24890088
91BTK0.23105230
92TYK20.22745269
93AKT20.22159114
94MAP2K20.22041668
95PRKCQ0.21780334
96MAP3K140.21676030
97EPHB20.21029186
98KDR0.18606045
99CSNK1D0.18036693
100CSNK2A20.17344527

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006044.48770507
2Ribosome_Homo sapiens_hsa030104.28537995
3Caffeine metabolism_Homo sapiens_hsa002324.13921907
4Allograft rejection_Homo sapiens_hsa053303.45920841
5Autoimmune thyroid disease_Homo sapiens_hsa053203.36684173
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.31721496
7African trypanosomiasis_Homo sapiens_hsa051433.25318429
8Graft-versus-host disease_Homo sapiens_hsa053323.10804884
9Type I diabetes mellitus_Homo sapiens_hsa049402.69670401
10Vitamin B6 metabolism_Homo sapiens_hsa007502.52865805
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.97456450
12Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.88539197
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.86822674
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84023326
15Linoleic acid metabolism_Homo sapiens_hsa005911.78181005
16Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.75748295
17Malaria_Homo sapiens_hsa051441.68972672
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68292307
19Type II diabetes mellitus_Homo sapiens_hsa049301.55854899
20Rheumatoid arthritis_Homo sapiens_hsa053231.46646094
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.36545822
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15260218
23Asthma_Homo sapiens_hsa053101.13813941
24Fat digestion and absorption_Homo sapiens_hsa049751.12096913
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.11042430
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10616098
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.00556628
28Hematopoietic cell lineage_Homo sapiens_hsa046400.97194173
29SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97033375
30Tryptophan metabolism_Homo sapiens_hsa003800.93299825
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93294409
32Retinol metabolism_Homo sapiens_hsa008300.93264138
33Nicotine addiction_Homo sapiens_hsa050330.83522918
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79075152
35Chemical carcinogenesis_Homo sapiens_hsa052040.78279176
36Prion diseases_Homo sapiens_hsa050200.77014044
37Pertussis_Homo sapiens_hsa051330.76857687
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75987195
39Pentose phosphate pathway_Homo sapiens_hsa000300.72054127
40Chemokine signaling pathway_Homo sapiens_hsa040620.71930268
41Renin secretion_Homo sapiens_hsa049240.71021023
42mTOR signaling pathway_Homo sapiens_hsa041500.70089318
43Phototransduction_Homo sapiens_hsa047440.69035927
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68736633
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67775961
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67456532
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66259225
48Primary immunodeficiency_Homo sapiens_hsa053400.65695862
49Morphine addiction_Homo sapiens_hsa050320.64223625
50Melanoma_Homo sapiens_hsa052180.63459136
51Olfactory transduction_Homo sapiens_hsa047400.63412288
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63400386
53Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62402177
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59918364
55Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.59350538
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59162880
57Cardiac muscle contraction_Homo sapiens_hsa042600.58943051
58Systemic lupus erythematosus_Homo sapiens_hsa053220.58726134
59Apoptosis_Homo sapiens_hsa042100.58146184
60B cell receptor signaling pathway_Homo sapiens_hsa046620.57973494
61Taste transduction_Homo sapiens_hsa047420.57722271
62cAMP signaling pathway_Homo sapiens_hsa040240.57622135
63Influenza A_Homo sapiens_hsa051640.57490911
64Arachidonic acid metabolism_Homo sapiens_hsa005900.57456325
65Staphylococcus aureus infection_Homo sapiens_hsa051500.57290298
66Measles_Homo sapiens_hsa051620.56587606
67Prolactin signaling pathway_Homo sapiens_hsa049170.55039295
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.53168530
69Oxidative phosphorylation_Homo sapiens_hsa001900.52695357
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.50891701
71GABAergic synapse_Homo sapiens_hsa047270.50646846
72ABC transporters_Homo sapiens_hsa020100.50643822
73Ras signaling pathway_Homo sapiens_hsa040140.50427959
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49133779
75Nitrogen metabolism_Homo sapiens_hsa009100.49004407
76Serotonergic synapse_Homo sapiens_hsa047260.46788250
77Cholinergic synapse_Homo sapiens_hsa047250.45726674
78Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45640269
79Complement and coagulation cascades_Homo sapiens_hsa046100.42655689
80Tyrosine metabolism_Homo sapiens_hsa003500.42020443
81Bile secretion_Homo sapiens_hsa049760.41509831
82Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41279071
83Basal transcription factors_Homo sapiens_hsa030220.40727476
84Rap1 signaling pathway_Homo sapiens_hsa040150.38190640
85Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37499073
86FoxO signaling pathway_Homo sapiens_hsa040680.33313638
87T cell receptor signaling pathway_Homo sapiens_hsa046600.33171437
88Platelet activation_Homo sapiens_hsa046110.32612038
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30960804
90Parkinsons disease_Homo sapiens_hsa050120.29007949
91Arginine and proline metabolism_Homo sapiens_hsa003300.27675478
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26472072
93Tuberculosis_Homo sapiens_hsa051520.24737021
94Insulin resistance_Homo sapiens_hsa049310.24510122
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24096824
96Protein digestion and absorption_Homo sapiens_hsa049740.23650880
97ECM-receptor interaction_Homo sapiens_hsa045120.22229837
98Leishmaniasis_Homo sapiens_hsa051400.21882703
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20609987
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19577380

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »