ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.73208335
2	translational termination (GO:0006415)	8.47592324
3	ribosomal small subunit assembly (GO:0000028)	8.09143933
4	translational elongation (GO:0006414)	7.27165497
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.05765026
6	cotranslational protein targeting to membrane (GO:0006613)	6.94747162
7	protein targeting to ER (GO:0045047)	6.90232404
8	ribosomal small subunit biogenesis (GO:0042274)	6.89693901
9	maturation of SSU-rRNA (GO:0030490)	6.74713755
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.56948200
11	cellular protein complex disassembly (GO:0043624)	6.49091635
12	protein localization to endoplasmic reticulum (GO:0070972)	6.48062925
13	viral life cycle (GO:0019058)	6.09784908
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.92686210
15	protein complex disassembly (GO:0043241)	5.52172397
16	macromolecular complex disassembly (GO:0032984)	5.14393815
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.13174658
18	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.13174658
19	translational initiation (GO:0006413)	5.10114926
20	nucleotide salvage (GO:0043173)	5.04894414
21	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	4.68681063
22	UMP metabolic process (GO:0046049)	4.68681063
23	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	4.68681063
24	UMP biosynthetic process (GO:0006222)	4.68681063
25	CTP biosynthetic process (GO:0006241)	4.66862668
26	CTP metabolic process (GO:0046036)	4.66862668
27	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.66285095
28	ATP synthesis coupled proton transport (GO:0015986)	4.66285095
29	protein targeting to membrane (GO:0006612)	4.63773466
30	pyrimidine nucleoside salvage (GO:0043097)	4.47383616
31	pyrimidine-containing compound salvage (GO:0008655)	4.47383616
32	regulation of activation of Janus kinase activity (GO:0010533)	4.37437653
33	nucleoside salvage (GO:0043174)	4.32498529
34	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	4.27206096
35	ribosomal large subunit biogenesis (GO:0042273)	4.22640238
36	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.20942774
37	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	4.16102793
38	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.07998000
39	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	3.99268893
40	* translation (GO:0006412)	3.94161856
41	mRNA catabolic process (GO:0006402)	3.85007183
42	behavioral response to nicotine (GO:0035095)	3.84655935
43	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	3.83061537
44	protein neddylation (GO:0045116)	3.77981418
45	protein complex biogenesis (GO:0070271)	3.77435886
46	DNA deamination (GO:0045006)	3.75103706
47	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.73967169
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63206366
49	RNA catabolic process (GO:0006401)	3.51617493
50	negative regulation of mast cell activation (GO:0033004)	3.49612094
51	mitochondrial respiratory chain complex assembly (GO:0033108)	3.48779662
52	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.43918839
53	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.33462750
54	keratinocyte development (GO:0003334)	3.24837612
55	terpenoid biosynthetic process (GO:0016114)	3.24284869
56	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	3.23859594
57	diterpenoid biosynthetic process (GO:0016102)	3.22744644
58	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22697907
59	NADH dehydrogenase complex assembly (GO:0010257)	3.22697907
60	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22697907
61	regulation of glycogen (starch) synthase activity (GO:2000465)	3.17560942
62	respiratory electron transport chain (GO:0022904)	3.16583081
63	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.15705597
64	electron transport chain (GO:0022900)	3.12808308
65	cell proliferation in forebrain (GO:0021846)	3.11087014
66	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	3.10102467
67	positive regulation of respiratory burst (GO:0060267)	3.07899565
68	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04813270
69	establishment of protein localization to membrane (GO:0090150)	2.98836353
70	somite development (GO:0061053)	2.96967190
71	establishment of mitochondrion localization (GO:0051654)	2.92823297
72	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.91076151
73	pentose metabolic process (GO:0019321)	2.89799784
74	kynurenine metabolic process (GO:0070189)	2.87359965
75	head development (GO:0060322)	2.85700062
76	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.85514716
77	cellular component biogenesis (GO:0044085)	2.85275737
78	GTP biosynthetic process (GO:0006183)	2.80702964
79	base-excision repair, AP site formation (GO:0006285)	2.78348373
80	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.77745903
81	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.77023197
82	mitochondrion transport along microtubule (GO:0047497)	2.77023197
83	protein targeting (GO:0006605)	2.74945299
84	hydrogen ion transmembrane transport (GO:1902600)	2.74068197
85	neuron fate determination (GO:0048664)	2.73322658
86	ribonucleoprotein complex biogenesis (GO:0022613)	2.72825436
87	pyrimidine ribonucleotide metabolic process (GO:0009218)	2.72687111
88	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.71161975
89	ATP biosynthetic process (GO:0006754)	2.68149031
90	pyrimidine nucleobase catabolic process (GO:0006208)	2.66854281
91	respiratory chain complex IV assembly (GO:0008535)	2.64483598
92	chaperone-mediated protein transport (GO:0072321)	2.64426037
93	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.63525518
94	indolalkylamine metabolic process (GO:0006586)	2.61906992
95	axonemal dynein complex assembly (GO:0070286)	2.60830514
96	pyrimidine nucleotide biosynthetic process (GO:0006221)	2.60392960
97	nucleoside triphosphate biosynthetic process (GO:0009142)	2.60303213
98	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.60160921
99	substrate-independent telencephalic tangential migration (GO:0021826)	2.60160921
100	cytidine catabolic process (GO:0006216)	2.58865298

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.70575827
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.28891241
3	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.22427086
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.39099738
5	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.28830247
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.22323256
7	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.16349568
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.10811898
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.06727321
10	STAT6_21828071_ChIP-Seq_BEAS2B_Human	2.05300757
11	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.03698617
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.01483161
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.95594397
14	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.95556641
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.90313794
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.88752762
17	IRF1_19129219_ChIP-ChIP_H3396_Human	1.86858884
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.82526932
19	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.82272858
20	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.80635848
21	VDR_22108803_ChIP-Seq_LS180_Human	1.80470054
22	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.71170812
23	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67544539
24	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.66976786
25	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.65640985
26	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58955382
27	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.58116301
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.55391877
29	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54796797
30	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.54293533
31	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.49584958
32	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.48232528
33	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.45887622
34	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.41348184
35	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.41348184
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.40735401
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.40459689
38	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.39816562
39	ERA_21632823_ChIP-Seq_H3396_Human	1.39124941
40	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.38219972
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.36240225
42	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.35940971
43	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.34118445
44	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.33504006
45	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.32418853
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.31248721
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30830803
48	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.29993242
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.27653082
50	RNF2_27304074_Chip-Seq_NSC_Mouse	1.26817656
51	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.22298046
52	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.21977492
53	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.21139382
54	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.21061641
55	CTCF_20526341_ChIP-Seq_ESCs_Human	1.20846174
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.20302796
57	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.19268199
58	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.19093115
59	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.18356217
60	MYC_18940864_ChIP-ChIP_HL60_Human	1.16651623
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16488250
62	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.16145976
63	SA1_27219007_Chip-Seq_Bcells_Human	1.15949688
64	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.15658774
65	NCOR_22424771_ChIP-Seq_293T_Human	1.14937618
66	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.14908281
67	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.13021543
68	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.12073412
69	ELK1_19687146_ChIP-ChIP_HELA_Human	1.11321121
70	NANOG_20526341_ChIP-Seq_ESCs_Human	1.10517736
71	GBX2_23144817_ChIP-Seq_PC3_Human	1.05819773
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05416506
73	CTCF_27219007_Chip-Seq_Bcells_Human	1.04801163
74	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.04046294
75	BCL6_27268052_Chip-Seq_Bcells_Human	1.03818556
76	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03567132
77	E2F1_20622854_ChIP-Seq_HELA_Human	1.02977285
78	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.02478977
79	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.01449548
80	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.00513582
81	VDR_23849224_ChIP-Seq_CD4+_Human	0.98187037
82	AR_20517297_ChIP-Seq_VCAP_Human	0.97926464
83	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.96948695
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.96521430
85	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.96386801
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96068085
87	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.96022049
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94940307
89	CBP_20019798_ChIP-Seq_JUKART_Human	0.93751050
90	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93751050
91	RAC3_21632823_ChIP-Seq_H3396_Human	0.93575234
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.92808887
93	TTF2_22483619_ChIP-Seq_HELA_Human	0.92546749
94	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92437620
95	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91418896
96	FOXP3_21729870_ChIP-Seq_TREG_Human	0.91250519
97	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.91104762
98	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.90020896
99	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.89968427
100	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.89968427

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.11579087
2	MP0003646_muscle_fatigue	5.33597486
3	MP0006292_abnormal_olfactory_placode	4.64839766
4	MP0002163_abnormal_gland_morphology	2.87838966
5	MP0004145_abnormal_muscle_electrophysio	2.23028255
6	MP0003787_abnormal_imprinting	2.20850697
7	MP0008875_abnormal_xenobiotic_pharmacok	2.11152201
8	MP0008789_abnormal_olfactory_epithelium	2.04416174
9	MP0008872_abnormal_physiological_respon	2.02503553
10	MP0003122_maternal_imprinting	2.01577767
11	MP0008877_abnormal_DNA_methylation	1.98764097
12	MP0002837_dystrophic_cardiac_calcinosis	1.89775454
13	MP0002653_abnormal_ependyma_morphology	1.83631767
14	MP0002234_abnormal_pharynx_morphology	1.82521236
15	MP0001293_anophthalmia	1.81891004
16	MP0004142_abnormal_muscle_tone	1.78003039
17	MP0003011_delayed_dark_adaptation	1.77526032
18	MP0001348_abnormal_lacrimal_gland	1.74738197
19	MP0000049_abnormal_middle_ear	1.70991754
20	MP0005499_abnormal_olfactory_system	1.66392098
21	MP0005394_taste/olfaction_phenotype	1.66392098
22	MP0005379_endocrine/exocrine_gland_phen	1.64606541
23	MP0002736_abnormal_nociception_after	1.62373246
24	MP0005551_abnormal_eye_electrophysiolog	1.58757710
25	MP0002638_abnormal_pupillary_reflex	1.58391961
26	MP0001968_abnormal_touch/_nociception	1.51216235
27	MP0006276_abnormal_autonomic_nervous	1.48422507
28	MP0005377_hearing/vestibular/ear_phenot	1.42507592
29	MP0003878_abnormal_ear_physiology	1.42507592
30	MP0005360_urolithiasis	1.38216901
31	MP0003121_genomic_imprinting	1.37615307
32	MP0005645_abnormal_hypothalamus_physiol	1.34551215
33	MP0004885_abnormal_endolymph	1.33693922
34	MP0005671_abnormal_response_to	1.30626080
35	MP0001919_abnormal_reproductive_system	1.30267766
36	MP0006072_abnormal_retinal_apoptosis	1.27586403
37	MP0002102_abnormal_ear_morphology	1.27043055
38	MP0002272_abnormal_nervous_system	1.20837418
39	MP0003136_yellow_coat_color	1.17654577
40	MP0005423_abnormal_somatic_nervous	1.16805444
41	MP0009745_abnormal_behavioral_response	1.15451958
42	MP0005389_reproductive_system_phenotype	1.13246622
43	MP0003195_calcinosis	1.12183624
44	MP0001485_abnormal_pinna_reflex	1.10863785
45	MP0001663_abnormal_digestive_system	1.10648610
46	MP0002095_abnormal_skin_pigmentation	1.09896337
47	MP0000631_abnormal_neuroendocrine_gland	1.09067817
48	MP0001873_stomach_inflammation	1.05426948
49	MP0002733_abnormal_thermal_nociception	1.05178209
50	MP0003880_abnormal_central_pattern	1.04867621
51	MP0003123_paternal_imprinting	1.04722327
52	MP0001986_abnormal_taste_sensitivity	1.02941453
53	MP0005195_abnormal_posterior_eye	1.02401754
54	MP0001970_abnormal_pain_threshold	1.00950809
55	MP0008775_abnormal_heart_ventricle	0.99510914
56	MP0002938_white_spotting	0.99501901
57	MP0002184_abnormal_innervation	0.98513013
58	MP0002822_catalepsy	0.95294445
59	MP0004742_abnormal_vestibular_system	0.93686025
60	MP0000026_abnormal_inner_ear	0.92253820
61	MP0002160_abnormal_reproductive_system	0.88980837
62	MP0001440_abnormal_grooming_behavior	0.88973746
63	MP0002752_abnormal_somatic_nervous	0.88711651
64	MP0002277_abnormal_respiratory_mucosa	0.88535289
65	MP0005646_abnormal_pituitary_gland	0.87808501
66	MP0002557_abnormal_social/conspecific_i	0.87032119
67	MP0001905_abnormal_dopamine_level	0.86981532
68	MP0004133_heterotaxia	0.86278184
69	MP0002735_abnormal_chemical_nociception	0.85250076
70	MP0005257_abnormal_intraocular_pressure	0.85070320
71	MP0004147_increased_porphyrin_level	0.84132608
72	MP0003119_abnormal_digestive_system	0.83345199
73	MP0005253_abnormal_eye_physiology	0.82805437
74	MP0001756_abnormal_urination	0.82290129
75	MP0003879_abnormal_hair_cell	0.81959108
76	MP0004858_abnormal_nervous_system	0.81039502
77	MP0010030_abnormal_orbit_morphology	0.80833775
78	MP0000778_abnormal_nervous_system	0.79913406
79	MP0001286_abnormal_eye_development	0.78120377
80	MP0003635_abnormal_synaptic_transmissio	0.77510211
81	MP0002233_abnormal_nose_morphology	0.77039816
82	MP0002572_abnormal_emotion/affect_behav	0.75933120
83	MP0009046_muscle_twitch	0.74858705
84	MP0003938_abnormal_ear_development	0.74268808
85	MP0001486_abnormal_startle_reflex	0.72615708
86	MP0000534_abnormal_ureter_morphology	0.70592371
87	MP0001963_abnormal_hearing_physiology	0.70563159
88	MP0005381_digestive/alimentary_phenotyp	0.70469257
89	MP0005391_vision/eye_phenotype	0.69887100
90	MP0005167_abnormal_blood-brain_barrier	0.68971258
91	MP0001502_abnormal_circadian_rhythm	0.68211035
92	MP0002063_abnormal_learning/memory/cond	0.67565496
93	MP0000955_abnormal_spinal_cord	0.67413184
94	MP0002064_seizures	0.65781088
95	MP0002932_abnormal_joint_morphology	0.65108033
96	MP0009250_abnormal_appendicular_skeleto	0.63616123
97	MP0000538_abnormal_urinary_bladder	0.62749420
98	MP0009764_decreased_sensitivity_to	0.60971265
99	MP0002734_abnormal_mechanical_nocicepti	0.60826820
100	MP0002933_joint_inflammation	0.60713640

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.46786678
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.46153942
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.46495894
4	Abnormal rod and cone electroretinograms (HP:0008323)	4.02704799
5	Acute necrotizing encephalopathy (HP:0006965)	3.89894962
6	Pendular nystagmus (HP:0012043)	3.79314990
7	Macrocytic anemia (HP:0001972)	3.55515058
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.40147678
9	Abnormal number of erythroid precursors (HP:0012131)	3.39794402
10	Mitochondrial inheritance (HP:0001427)	3.34170675
11	Acute encephalopathy (HP:0006846)	3.33058515
12	Increased hepatocellular lipid droplets (HP:0006565)	3.24320670
13	Pallor (HP:0000980)	3.23072181
14	Hyperglycinemia (HP:0002154)	3.22903699
15	Progressive macrocephaly (HP:0004481)	3.13440612
16	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.12441178
17	Asplenia (HP:0001746)	3.11859040
18	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.09471375
19	Abnormality of midbrain morphology (HP:0002418)	3.05213937
20	Molar tooth sign on MRI (HP:0002419)	3.05213937
21	Hip dysplasia (HP:0001385)	2.99900355
22	Decreased central vision (HP:0007663)	2.96357222
23	Congenital stationary night blindness (HP:0007642)	2.93524802
24	Renal Fanconi syndrome (HP:0001994)	2.90043215
25	Increased CSF lactate (HP:0002490)	2.89066535
26	Hypoplasia of the pons (HP:0012110)	2.88787879
27	Pancreatic fibrosis (HP:0100732)	2.83186695
28	Pancreatic cysts (HP:0001737)	2.82921609
29	Lipid accumulation in hepatocytes (HP:0006561)	2.82202885
30	Abnormal ciliary motility (HP:0012262)	2.76795961
31	Agitation (HP:0000713)	2.73422039
32	Septo-optic dysplasia (HP:0100842)	2.72491976
33	Colon cancer (HP:0003003)	2.72106834
34	Myokymia (HP:0002411)	2.58568113
35	Abnormality of the pons (HP:0007361)	2.54712500
36	Attenuation of retinal blood vessels (HP:0007843)	2.52938976
37	Dyskinesia (HP:0100660)	2.50983509
38	Optic disc pallor (HP:0000543)	2.47759764
39	Stenosis of the external auditory canal (HP:0000402)	2.47692097
40	Increased corneal curvature (HP:0100692)	2.38632195
41	Keratoconus (HP:0000563)	2.38632195
42	Absent thumb (HP:0009777)	2.36945218
43	Increased intramyocellular lipid droplets (HP:0012240)	2.36612745
44	Abnormal respiratory motile cilium physiology (HP:0012261)	2.33569038
45	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31119516
46	Supernumerary spleens (HP:0009799)	2.26381692
47	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.24419706
48	Hepatocellular necrosis (HP:0001404)	2.24269778
49	Restlessness (HP:0000711)	2.24140938
50	Short femoral neck (HP:0100864)	2.23959788
51	True hermaphroditism (HP:0010459)	2.23819071
52	Cerebral edema (HP:0002181)	2.23370917
53	Carpal bone hypoplasia (HP:0001498)	2.22089128
54	Abnormality of renal resorption (HP:0011038)	2.19502499
55	Poor suck (HP:0002033)	2.18214009
56	Partial duplication of thumb phalanx (HP:0009944)	2.17978507
57	Polyuria (HP:0000103)	2.16637455
58	Difficulty running (HP:0009046)	2.11669775
59	Abnormal drinking behavior (HP:0030082)	2.11216267
60	Polydipsia (HP:0001959)	2.11216267
61	Sclerocornea (HP:0000647)	2.10704960
62	Medial flaring of the eyebrow (HP:0010747)	2.08785491
63	Nephronophthisis (HP:0000090)	2.06808313
64	Congenital, generalized hypertrichosis (HP:0004540)	2.04841095
65	Delayed CNS myelination (HP:0002188)	2.02631053
66	Hepatic necrosis (HP:0002605)	2.00651393
67	Postaxial foot polydactyly (HP:0001830)	2.00456741
68	Hypoplasia of the ulna (HP:0003022)	1.99369655
69	Abnormality of the renal cortex (HP:0011035)	1.98650530
70	Porencephaly (HP:0002132)	1.97491776
71	Cerebral hypomyelination (HP:0006808)	1.97076630
72	Hip contracture (HP:0003273)	1.95853379
73	Absent/shortened dynein arms (HP:0200106)	1.92228422
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92228422
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.91997880
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.91997880
77	Synostosis of carpal bones (HP:0005048)	1.91580229
78	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.90500758
79	Anencephaly (HP:0002323)	1.87846933
80	Rib fusion (HP:0000902)	1.87800044
81	Abnormality of the renal medulla (HP:0100957)	1.86301505
82	Exertional dyspnea (HP:0002875)	1.85745097
83	Hypoplasia of the radius (HP:0002984)	1.84987699
84	Hyperphosphaturia (HP:0003109)	1.84901726
85	3-Methylglutaconic aciduria (HP:0003535)	1.83494886
86	11 pairs of ribs (HP:0000878)	1.83105873
87	Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)	1.82951247
88	Maternal diabetes (HP:0009800)	1.81565418
89	Cystic liver disease (HP:0006706)	1.81320777
90	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.80276610
91	Increased muscle lipid content (HP:0009058)	1.80064139
92	Partial duplication of the phalanx of hand (HP:0009999)	1.79354470
93	Anophthalmia (HP:0000528)	1.78515784
94	Abnormal urine output (HP:0012590)	1.78018942
95	Abnormality of urine glucose concentration (HP:0011016)	1.77885297
96	Glycosuria (HP:0003076)	1.77885297
97	Type 2 muscle fiber atrophy (HP:0003554)	1.76425176
98	Abnormality of the diencephalon (HP:0010662)	1.76097170
99	Type II lissencephaly (HP:0007260)	1.75993816
100	Depressed nasal ridge (HP:0000457)	1.75759742

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	5.46220090
2	MAP4K1	3.52692525
3	WNK4	2.45605698
4	PINK1	2.40712264
5	TXK	2.37766694
6	STK16	2.35001614
7	GRK1	2.31233306
8	NME2	2.25156862
9	CAMKK2	2.06933654
10	ADRBK2	2.00076784
11	DYRK2	1.98875168
12	TLK1	1.97339153
13	BCKDK	1.85289798
14	WNK3	1.83019254
15	MAP3K11	1.82087622
16	LRRK2	1.82082142
17	PIK3CA	1.56482029
18	CAMKK1	1.48185828
19	PRKCG	1.47059952
20	TIE1	1.46421938
21	EPHB2	1.43032007
22	TRIM28	1.39626437
23	FRK	1.36901256
24	MAP2K7	1.35819952
25	CAMK1	1.34724432
26	CDC42BPA	1.33558789
27	TESK1	1.29939563
28	KDR	1.25617809
29	NTRK2	1.18942280
30	PASK	1.17116621
31	ACVR1B	1.16568346
32	PRKCQ	1.15821352
33	CDK19	1.13250170
34	TESK2	1.12995828
35	CASK	1.11625895
36	AURKA	1.09174548
37	OBSCN	1.07599185
38	INSRR	1.07402890
39	MAP3K4	1.05300595
40	ITK	1.02119421
41	STK39	1.00256634
42	ADRBK1	1.00153169
43	BMPR1B	0.97873293
44	PLK2	0.90728615
45	ZAK	0.88596329
46	NLK	0.88340765
47	NUAK1	0.84969464
48	BRSK1	0.84195584
49	MINK1	0.82925307
50	ABL2	0.82130764
51	MAP4K2	0.80429102
52	RPS6KA5	0.79314589
53	PRKACA	0.77679191
54	GRK7	0.76716706
55	TNIK	0.71223892
56	OXSR1	0.71001406
57	GRK6	0.69356603
58	CSNK2A2	0.69256233
59	PKN1	0.68453601
60	NEK1	0.68139056
61	SGK494	0.66861457
62	SGK223	0.66861457
63	LCK	0.61660034
64	NME1	0.60711658
65	CSF1R	0.60394107
66	ROCK1	0.60185703
67	MUSK	0.60063166
68	EPHA4	0.59519679
69	PRKCA	0.59139482
70	MAPK15	0.58314528
71	CSNK2A1	0.57964790
72	MYLK	0.57571987
73	PHKG2	0.57496417
74	PHKG1	0.57496417
75	DAPK3	0.57147103
76	BRAF	0.56753336
77	PAK3	0.56539738
78	MAPK13	0.56097833
79	CDK8	0.55945649
80	CAMK2A	0.54378256
81	MARK1	0.54310661
82	SYK	0.49292375
83	VRK2	0.48014722
84	VRK1	0.47137394
85	CSNK1G1	0.46051791
86	TAOK3	0.45497454
87	CAMK4	0.44155589
88	BTK	0.43774355
89	NTRK3	0.42652373
90	LYN	0.41606988
91	PIM1	0.41230070
92	PLK1	0.40666675
93	SGK2	0.40405697
94	CDC7	0.40242489
95	TEC	0.40233836
96	PRKACG	0.40095346
97	RPS6KA6	0.39498564
98	PDK2	0.38989339
99	SGK1	0.38791582
100	CSNK1A1	0.38243199

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.34033339
2	Sulfur relay system_Homo sapiens_hsa04122	3.93802683
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.78280808
4	Parkinsons disease_Homo sapiens_hsa05012	3.08241313
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.69210153
6	Alzheimers disease_Homo sapiens_hsa05010	2.35024834
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28784584
8	Huntingtons disease_Homo sapiens_hsa05016	2.16710114
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.14058628
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.12548501
11	RNA polymerase_Homo sapiens_hsa03020	1.77089290
12	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.69209895
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.67230837
14	Phototransduction_Homo sapiens_hsa04744	1.66604283
15	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57629672
16	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.54725749
17	Pyrimidine metabolism_Homo sapiens_hsa00240	1.53228706
18	Protein export_Homo sapiens_hsa03060	1.53189991
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.41225251
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.39917274
21	Nicotine addiction_Homo sapiens_hsa05033	1.39031991
22	Fat digestion and absorption_Homo sapiens_hsa04975	1.37158015
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.33173450
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.29427640
25	RNA degradation_Homo sapiens_hsa03018	1.29420000
26	Caffeine metabolism_Homo sapiens_hsa00232	1.22308381
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.20186232
28	Olfactory transduction_Homo sapiens_hsa04740	1.13299469
29	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.08753494
30	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.05849106
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.03150969
32	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.00939849
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.00406980
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.98767180
35	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.96227112
36	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.95266051
37	Butanoate metabolism_Homo sapiens_hsa00650	0.94088169
38	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.90401210
39	Homologous recombination_Homo sapiens_hsa03440	0.89950891
40	Asthma_Homo sapiens_hsa05310	0.89932147
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.88486632
42	Proteasome_Homo sapiens_hsa03050	0.87743006
43	Peroxisome_Homo sapiens_hsa04146	0.87443464
44	Allograft rejection_Homo sapiens_hsa05330	0.85527228
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.85503512
46	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82286683
47	Retinol metabolism_Homo sapiens_hsa00830	0.82220931
48	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.81971617
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81818971
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.80147913
51	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.76959939
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75062263
53	Graft-versus-host disease_Homo sapiens_hsa05332	0.71154909
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.70989912
55	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69949893
56	Morphine addiction_Homo sapiens_hsa05032	0.69765642
57	Metabolic pathways_Homo sapiens_hsa01100	0.68973353
58	Basal cell carcinoma_Homo sapiens_hsa05217	0.68540863
59	DNA replication_Homo sapiens_hsa03030	0.66373446
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65408702
61	Insulin secretion_Homo sapiens_hsa04911	0.65220456
62	Fatty acid elongation_Homo sapiens_hsa00062	0.64819786
63	Purine metabolism_Homo sapiens_hsa00230	0.61110039
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.60905468
65	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59526769
66	Taste transduction_Homo sapiens_hsa04742	0.58206470
67	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.56860484
68	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.53190876
69	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51309514
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.50718054
71	GABAergic synapse_Homo sapiens_hsa04727	0.50439196
72	beta-Alanine metabolism_Homo sapiens_hsa00410	0.48636666
73	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.47422777
74	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46854015
75	Pentose phosphate pathway_Homo sapiens_hsa00030	0.46312756
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.44896404
77	Ether lipid metabolism_Homo sapiens_hsa00565	0.43345851
78	Salivary secretion_Homo sapiens_hsa04970	0.42992781
79	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42599077
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40872517
81	Glutamatergic synapse_Homo sapiens_hsa04724	0.39791732
82	Serotonergic synapse_Homo sapiens_hsa04726	0.39175579
83	Basal transcription factors_Homo sapiens_hsa03022	0.36250906
84	Circadian entrainment_Homo sapiens_hsa04713	0.34946422
85	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32615808
86	Axon guidance_Homo sapiens_hsa04360	0.31404643
87	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.30064303
88	Propanoate metabolism_Homo sapiens_hsa00640	0.29849737
89	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29456835
90	Antigen processing and presentation_Homo sapiens_hsa04612	0.27850903
91	Malaria_Homo sapiens_hsa05144	0.23538899
92	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.23372751
93	Rheumatoid arthritis_Homo sapiens_hsa05323	0.22763089
94	Nucleotide excision repair_Homo sapiens_hsa03420	0.22618661
95	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.22105606
96	Pancreatic secretion_Homo sapiens_hsa04972	0.21857624
97	Mineral absorption_Homo sapiens_hsa04978	0.21653391
98	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.21121969
99	Sulfur metabolism_Homo sapiens_hsa00920	0.20273034
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.19938177

RPL37AP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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