ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	maturation of SSU-rRNA (GO:0030490)	6.61187309
2	viral transcription (GO:0019083)	5.55320269
3	behavioral response to nicotine (GO:0035095)	5.49289344
4	translational termination (GO:0006415)	5.27317844
5	ribosomal small subunit biogenesis (GO:0042274)	5.17210400
6	ribosomal small subunit assembly (GO:0000028)	5.10924515
7	ubiquinone biosynthetic process (GO:0006744)	5.10296835
8	platelet dense granule organization (GO:0060155)	4.60571567
9	ubiquinone metabolic process (GO:0006743)	4.51484212
10	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.50474225
11	translational elongation (GO:0006414)	4.34228204
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.30992647
13	rRNA catabolic process (GO:0016075)	4.30839860
14	protein targeting to ER (GO:0045047)	4.29752029
15	cotranslational protein targeting to membrane (GO:0006613)	4.22057861
16	quinone biosynthetic process (GO:1901663)	4.14129490
17	ATP synthesis coupled proton transport (GO:0015986)	4.12288493
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.12288493
19	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.10731637
20	protein localization to endoplasmic reticulum (GO:0070972)	4.03508244
21	viral life cycle (GO:0019058)	4.01393880
22	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.93547583
23	cellular protein complex disassembly (GO:0043624)	3.92577742
24	pyrimidine nucleobase catabolic process (GO:0006208)	3.91446844
25	indole-containing compound catabolic process (GO:0042436)	3.77259853
26	indolalkylamine catabolic process (GO:0046218)	3.77259853
27	tryptophan catabolic process (GO:0006569)	3.77259853
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.75752903
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.75752903
30	positive regulation of respiratory burst (GO:0060267)	3.72887714
31	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.69447994
32	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.69028982
33	indolalkylamine metabolic process (GO:0006586)	3.67465998
34	trivalent inorganic anion homeostasis (GO:0072506)	3.66760031
35	phosphate ion homeostasis (GO:0055062)	3.66760031
36	epithelial cilium movement (GO:0003351)	3.57172238
37	negative regulation of telomere maintenance (GO:0032205)	3.52188065
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.46717130
39	ribosomal large subunit biogenesis (GO:0042273)	3.43809137
40	kynurenine metabolic process (GO:0070189)	3.43296257
41	maturation of 5.8S rRNA (GO:0000460)	3.41470010
42	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.41425953
43	tryptophan metabolic process (GO:0006568)	3.35827571
44	protein complex biogenesis (GO:0070271)	3.34627782
45	protein complex disassembly (GO:0043241)	3.34393919
46	translational initiation (GO:0006413)	3.32165767
47	macromolecular complex disassembly (GO:0032984)	3.30456968
48	organelle disassembly (GO:1903008)	3.25320125
49	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.22348959
50	NADH dehydrogenase complex assembly (GO:0010257)	3.22348959
51	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.22348959
52	iron-sulfur cluster assembly (GO:0016226)	3.20930108
53	metallo-sulfur cluster assembly (GO:0031163)	3.20930108
54	pyrimidine nucleotide catabolic process (GO:0006244)	3.20486439
55	GPI anchor metabolic process (GO:0006505)	3.18046928
56	kidney morphogenesis (GO:0060993)	3.13318369
57	regulation of cilium movement (GO:0003352)	3.11737586
58	GPI anchor biosynthetic process (GO:0006506)	3.10343137
59	nucleobase catabolic process (GO:0046113)	3.09477464
60	cellular ketone body metabolic process (GO:0046950)	3.09210613
61	response to pheromone (GO:0019236)	3.08274110
62	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08160973
63	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.07001164
64	amine catabolic process (GO:0009310)	3.05140436
65	cellular biogenic amine catabolic process (GO:0042402)	3.05140436
66	cell proliferation in forebrain (GO:0021846)	3.04058229
67	protein neddylation (GO:0045116)	3.01816427
68	cellular anion homeostasis (GO:0030002)	3.01585676
69	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.99376063
70	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.96452536
71	nonmotile primary cilium assembly (GO:0035058)	2.93429495
72	electron transport chain (GO:0022900)	2.93091165
73	positive regulation of fatty acid transport (GO:2000193)	2.92951450
74	mitochondrial respiratory chain complex assembly (GO:0033108)	2.92553899
75	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.88785050
76	respiratory electron transport chain (GO:0022904)	2.88396368
77	chaperone-mediated protein transport (GO:0072321)	2.86227378
78	protein targeting to membrane (GO:0006612)	2.83607713
79	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.79635153
80	ribonucleoprotein complex disassembly (GO:0032988)	2.78882910
81	aromatic amino acid family catabolic process (GO:0009074)	2.78258262
82	GTP biosynthetic process (GO:0006183)	2.77133388
83	somite development (GO:0061053)	2.74718604
84	ketone body metabolic process (GO:1902224)	2.74068087
85	positive regulation of prostaglandin secretion (GO:0032308)	2.73739341
86	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.71659527
87	autophagic vacuole fusion (GO:0000046)	2.71513807
88	L-fucose catabolic process (GO:0042355)	2.65718048
89	fucose catabolic process (GO:0019317)	2.65718048
90	L-fucose metabolic process (GO:0042354)	2.65718048
91	tyrosine phosphorylation of STAT protein (GO:0007260)	2.64936154
92	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.63800389
93	ncRNA catabolic process (GO:0034661)	2.58685426
94	synaptic transmission, cholinergic (GO:0007271)	2.56992444
95	base-excision repair, AP site formation (GO:0006285)	2.56837511
96	ovulation cycle (GO:0042698)	2.56052953
97	cilium movement (GO:0003341)	2.54680095
98	translation (GO:0006412)	2.54089797
99	auditory receptor cell stereocilium organization (GO:0060088)	2.52978557
100	protein import into peroxisome matrix (GO:0016558)	2.52912769

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.00249916
2	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.80467759
3	IGF1R_20145208_ChIP-Seq_DFB_Human	2.76221781
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.60396253
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.49863968
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.38478111
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.37774444
8	VDR_22108803_ChIP-Seq_LS180_Human	2.33028818
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.25617038
10	MYC_18940864_ChIP-ChIP_HL60_Human	2.21306228
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.14507063
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12913323
13	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.02153568
14	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.92163938
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.90005215
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.84738203
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.80120254
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.75979690
19	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.73052580
20	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72207250
21	RNF2_27304074_Chip-Seq_NSC_Mouse	1.72161657
22	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.69086303
23	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.67903106
24	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.62813272
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.62604919
26	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62090385
27	FUS_26573619_Chip-Seq_HEK293_Human	1.60295646
28	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.59898161
29	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.49321657
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.48787155
31	NCOR_22424771_ChIP-Seq_293T_Human	1.48764277
32	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.47868147
33	CBP_20019798_ChIP-Seq_JUKART_Human	1.47868147
34	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47064195
35	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.46268343
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.42921872
37	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40472022
38	TAF2_19829295_ChIP-Seq_ESCs_Human	1.38373135
39	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.38343620
40	REST_21632747_ChIP-Seq_MESCs_Mouse	1.38107012
41	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.37650947
42	ERA_21632823_ChIP-Seq_H3396_Human	1.37117691
43	NANOG_20526341_ChIP-Seq_ESCs_Human	1.33836602
44	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33661185
45	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.33641368
46	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.32544134
47	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28677073
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.28580471
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.24806857
50	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.22463454
51	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.22264776
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20999028
53	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.19965683
54	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.18826706
55	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.18680406
56	EWS_26573619_Chip-Seq_HEK293_Human	1.18665227
57	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.16782565
58	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.16369891
59	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.14268985
60	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.13436757
61	MYC_19829295_ChIP-Seq_ESCs_Human	1.12944291
62	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.11636307
63	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11236461
64	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.10833794
65	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10185328
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10185328
67	TAF15_26573619_Chip-Seq_HEK293_Human	1.10002759
68	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.08408087
69	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.07864043
70	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.07555239
71	CIITA_25753668_ChIP-Seq_RAJI_Human	1.06004798
72	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05583942
73	FOXP3_21729870_ChIP-Seq_TREG_Human	1.05325209
74	GBX2_23144817_ChIP-Seq_PC3_Human	1.04938572
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.04645097
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.03905038
77	P300_19829295_ChIP-Seq_ESCs_Human	1.03553937
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03060460
79	AR_20517297_ChIP-Seq_VCAP_Human	1.02914970
80	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.02746329
81	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02525352
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.02336884
83	STAT1_20625510_ChIP-Seq_HELA_Human	1.01405919
84	TTF2_22483619_ChIP-Seq_HELA_Human	1.00727458
85	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.99625762
86	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99112255
87	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99112255
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98929865
89	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.98489131
90	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.98428141
91	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.98278713
92	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.98190494
93	ELK1_19687146_ChIP-ChIP_HELA_Human	0.98114260
94	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.97686623
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.97577251
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97081371
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.97052581
98	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.96024947
99	RAC3_21632823_ChIP-Seq_H3396_Human	0.95386036
100	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93928501

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.88711669
2	MP0006292_abnormal_olfactory_placode	4.33694910
3	MP0005084_abnormal_gallbladder_morpholo	3.50210359
4	MP0002163_abnormal_gland_morphology	3.48042040
5	MP0005646_abnormal_pituitary_gland	2.60091307
6	MP0010368_abnormal_lymphatic_system	2.50516037
7	MP0002138_abnormal_hepatobiliary_system	2.39201361
8	MP0004885_abnormal_endolymph	2.38280596
9	MP0002928_abnormal_bile_duct	2.35362447
10	MP0002837_dystrophic_cardiac_calcinosis	2.10396022
11	MP0005174_abnormal_tail_pigmentation	2.08209465
12	MP0003646_muscle_fatigue	2.00330998
13	MP0002102_abnormal_ear_morphology	1.94788453
14	MP0003878_abnormal_ear_physiology	1.88241787
15	MP0005377_hearing/vestibular/ear_phenot	1.88241787
16	MP0001968_abnormal_touch/_nociception	1.86060962
17	MP0006276_abnormal_autonomic_nervous	1.84096952
18	MP0005379_endocrine/exocrine_gland_phen	1.76703033
19	MP0008872_abnormal_physiological_respon	1.76500179
20	MP0003252_abnormal_bile_duct	1.75870222
21	MP0001986_abnormal_taste_sensitivity	1.71156308
22	MP0005551_abnormal_eye_electrophysiolog	1.70361977
23	MP0001984_abnormal_olfaction	1.64828377
24	MP0002160_abnormal_reproductive_system	1.64117464
25	MP0002095_abnormal_skin_pigmentation	1.63256695
26	MP0005645_abnormal_hypothalamus_physiol	1.61069319
27	MP0002638_abnormal_pupillary_reflex	1.59759149
28	MP0008789_abnormal_olfactory_epithelium	1.59484356
29	MP0000015_abnormal_ear_pigmentation	1.58047870
30	MP0004142_abnormal_muscle_tone	1.50498475
31	MP0003879_abnormal_hair_cell	1.50048608
32	MP0004742_abnormal_vestibular_system	1.47669053
33	MP0001485_abnormal_pinna_reflex	1.45867193
34	MP0002733_abnormal_thermal_nociception	1.43626736
35	MP0008875_abnormal_xenobiotic_pharmacok	1.42266554
36	MP0002653_abnormal_ependyma_morphology	1.41730627
37	MP0003122_maternal_imprinting	1.41264409
38	MP0006072_abnormal_retinal_apoptosis	1.38730269
39	MP0003880_abnormal_central_pattern	1.34399909
40	MP0002272_abnormal_nervous_system	1.34131205
41	MP0001188_hyperpigmentation	1.33479702
42	MP0003787_abnormal_imprinting	1.32761928
43	MP0000372_irregular_coat_pigmentation	1.32480326
44	MP0005389_reproductive_system_phenotype	1.32176847
45	MP0004043_abnormal_pH_regulation	1.31803425
46	MP0008775_abnormal_heart_ventricle	1.30883562
47	MP0002938_white_spotting	1.24635729
48	MP0002234_abnormal_pharynx_morphology	1.22218582
49	MP0005394_taste/olfaction_phenotype	1.16791336
50	MP0005499_abnormal_olfactory_system	1.16791336
51	MP0005083_abnormal_biliary_tract	1.16230388
52	MP0001293_anophthalmia	1.14392545
53	MP0001970_abnormal_pain_threshold	1.12227370
54	MP0000026_abnormal_inner_ear	1.10638313
55	MP0005195_abnormal_posterior_eye	1.09201685
56	MP0001905_abnormal_dopamine_level	1.06885185
57	MP0005671_abnormal_response_to	1.04898443
58	MP0001346_abnormal_lacrimal_gland	1.04073541
59	MP0000631_abnormal_neuroendocrine_gland	1.03905296
60	MP0000427_abnormal_hair_cycle	0.99384147
61	MP0009745_abnormal_behavioral_response	0.98222400
62	MP0001440_abnormal_grooming_behavior	0.96478803
63	MP0010386_abnormal_urinary_bladder	0.95577839
64	MP0002184_abnormal_innervation	0.94909276
65	MP0009764_decreased_sensitivity_to	0.93955309
66	MP0000049_abnormal_middle_ear	0.93816791
67	MP0001963_abnormal_hearing_physiology	0.93505317
68	MP0003121_genomic_imprinting	0.91805987
69	MP0005410_abnormal_fertilization	0.90260033
70	MP0000230_abnormal_systemic_arterial	0.89795751
71	MP0005220_abnormal_exocrine_pancreas	0.89755108
72	MP0004145_abnormal_muscle_electrophysio	0.87089302
73	MP0002752_abnormal_somatic_nervous	0.86175146
74	MP0003283_abnormal_digestive_organ	0.84946331
75	MP0010030_abnormal_orbit_morphology	0.84700795
76	MP0002572_abnormal_emotion/affect_behav	0.84307235
77	MP0002736_abnormal_nociception_after	0.83689372
78	MP0002822_catalepsy	0.83155957
79	MP0000778_abnormal_nervous_system	0.83056319
80	MP0001879_abnormal_lymphatic_vessel	0.82332032
81	MP0002557_abnormal_social/conspecific_i	0.81050768
82	MP0002063_abnormal_learning/memory/cond	0.77883491
83	MP0002735_abnormal_chemical_nociception	0.77371666
84	MP0003136_yellow_coat_color	0.76258149
85	MP0001348_abnormal_lacrimal_gland	0.75927610
86	MP0000569_abnormal_digit_pigmentation	0.74439540
87	MP0008877_abnormal_DNA_methylation	0.74069132
88	MP0003195_calcinosis	0.73172699
89	MP0000955_abnormal_spinal_cord	0.71734231
90	MP0009046_muscle_twitch	0.71630305
91	MP0003638_abnormal_response/metabolism_	0.71499991
92	MP0003186_abnormal_redox_activity	0.70662419
93	MP0003635_abnormal_synaptic_transmissio	0.70393591
94	MP0001324_abnormal_eye_pigmentation	0.69880289
95	MP0001486_abnormal_startle_reflex	0.69538460
96	MP0002233_abnormal_nose_morphology	0.67160846
97	MP0003123_paternal_imprinting	0.66121334
98	MP0008058_abnormal_DNA_repair	0.64515572
99	MP0005423_abnormal_somatic_nervous	0.64081481
100	MP0000613_abnormal_salivary_gland	0.62372177

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.56822714
2	Abnormality of cells of the erythroid lineage (HP:0012130)	3.82518308
3	Pancreatic fibrosis (HP:0100732)	3.60149895
4	Abnormality of midbrain morphology (HP:0002418)	3.57944144
5	Molar tooth sign on MRI (HP:0002419)	3.57944144
6	Stenosis of the external auditory canal (HP:0000402)	3.19153644
7	Absent/shortened dynein arms (HP:0200106)	3.18141626
8	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.18141626
9	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.15229468
10	Failure to thrive in infancy (HP:0001531)	3.14052603
11	Lipid accumulation in hepatocytes (HP:0006561)	3.13928744
12	Increased hepatocellular lipid droplets (HP:0006565)	3.13617740
13	Pancreatic cysts (HP:0001737)	3.06409632
14	Increased intramyocellular lipid droplets (HP:0012240)	3.06392672
15	Acute necrotizing encephalopathy (HP:0006965)	3.04947709
16	True hermaphroditism (HP:0010459)	2.98648978
17	Pendular nystagmus (HP:0012043)	2.95600214
18	Medial flaring of the eyebrow (HP:0010747)	2.95592182
19	Congenital stationary night blindness (HP:0007642)	2.93453210
20	Mitochondrial inheritance (HP:0001427)	2.90792477
21	Abnormal rod and cone electroretinograms (HP:0008323)	2.87572743
22	Type II lissencephaly (HP:0007260)	2.86853822
23	Abnormal mitochondria in muscle tissue (HP:0008316)	2.84549011
24	Nephronophthisis (HP:0000090)	2.81416542
25	Increased CSF lactate (HP:0002490)	2.80769608
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.74196197
27	Abnormal respiratory epithelium morphology (HP:0012253)	2.74196197
28	Renal Fanconi syndrome (HP:0001994)	2.73133573
29	Macrocytic anemia (HP:0001972)	2.71436621
30	Increased muscle lipid content (HP:0009058)	2.66143780
31	Abnormality of the renal medulla (HP:0100957)	2.54778177
32	Exertional dyspnea (HP:0002875)	2.52950536
33	Acute encephalopathy (HP:0006846)	2.51798379
34	Microretrognathia (HP:0000308)	2.49986628
35	Abnormal number of erythroid precursors (HP:0012131)	2.47858965
36	Progressive macrocephaly (HP:0004481)	2.45235949
37	Septo-optic dysplasia (HP:0100842)	2.42948297
38	Gait imbalance (HP:0002141)	2.38423823
39	Methylmalonic acidemia (HP:0002912)	2.35628694
40	Hypoplasia of the pons (HP:0012110)	2.33870767
41	Pallor (HP:0000980)	2.33667876
42	Elevated erythrocyte sedimentation rate (HP:0003565)	2.33057488
43	Congenital primary aphakia (HP:0007707)	2.32962418
44	Prostate neoplasm (HP:0100787)	2.32755473
45	Nephrogenic diabetes insipidus (HP:0009806)	2.31161478
46	Abolished electroretinogram (ERG) (HP:0000550)	2.30107689
47	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26189972
48	Attenuation of retinal blood vessels (HP:0007843)	2.23128937
49	Postaxial foot polydactyly (HP:0001830)	2.22149245
50	Decreased central vision (HP:0007663)	2.20781679
51	Abnormal hemoglobin (HP:0011902)	2.19521344
52	Abnormal ciliary motility (HP:0012262)	2.19471001
53	Asplenia (HP:0001746)	2.17766577
54	Abnormality of the renal cortex (HP:0011035)	2.17026691
55	Hyperglycinemia (HP:0002154)	2.14569256
56	Abnormality of the pons (HP:0007361)	2.14273981
57	Tachypnea (HP:0002789)	2.13165059
58	Methylmalonic aciduria (HP:0012120)	2.13106164
59	Pachygyria (HP:0001302)	2.12683905
60	Sclerocornea (HP:0000647)	2.11750521
61	Absent thumb (HP:0009777)	2.11720497
62	Abnormality of the prostate (HP:0008775)	2.11347162
63	Esotropia (HP:0000565)	2.10363388
64	Colon cancer (HP:0003003)	2.10035483
65	Hepatocellular necrosis (HP:0001404)	2.08103444
66	Type 2 muscle fiber atrophy (HP:0003554)	2.07729498
67	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07393144
68	Hyperphosphatemia (HP:0002905)	2.07295463
69	Cystic liver disease (HP:0006706)	2.07154569
70	Supernumerary spleens (HP:0009799)	2.05412185
71	Ketosis (HP:0001946)	2.05333519
72	Polyuria (HP:0000103)	2.04702291
73	Hyperphosphaturia (HP:0003109)	2.02740016
74	Abnormal drinking behavior (HP:0030082)	2.01853350
75	Polydipsia (HP:0001959)	2.01853350
76	Optic disc pallor (HP:0000543)	2.01273152
77	Increased serum lactate (HP:0002151)	1.98799411
78	Abnormality of renal resorption (HP:0011038)	1.97720870
79	Respiratory difficulties (HP:0002880)	1.92800848
80	Neoplasm of the adrenal cortex (HP:0100641)	1.90618267
81	Anencephaly (HP:0002323)	1.90200902
82	Myokymia (HP:0002411)	1.89160310
83	Abnormality of cochlea (HP:0000375)	1.89098846
84	Status epilepticus (HP:0002133)	1.88357693
85	Hepatic necrosis (HP:0002605)	1.87895777
86	Cerebral edema (HP:0002181)	1.87693523
87	Congenital hepatic fibrosis (HP:0002612)	1.84779605
88	Ketoacidosis (HP:0001993)	1.84414169
89	Genital tract atresia (HP:0001827)	1.83767656
90	Concave nail (HP:0001598)	1.83648268
91	Cerebellar dysplasia (HP:0007033)	1.81218015
92	Acute hepatic failure (HP:0006554)	1.80496471
93	Vaginal atresia (HP:0000148)	1.79762174
94	Increased corneal curvature (HP:0100692)	1.79475344
95	Keratoconus (HP:0000563)	1.79475344
96	Anophthalmia (HP:0000528)	1.79230943
97	Enlarged kidneys (HP:0000105)	1.78582254
98	Lissencephaly (HP:0001339)	1.78123320
99	Congenital, generalized hypertrichosis (HP:0004540)	1.75903791
100	Abnormal urine phosphate concentration (HP:0012599)	1.75303762

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.51296623
2	STK16	4.00065758
3	MAP4K2	3.97530034
4	BCKDK	3.54081764
5	TIE1	3.39253958
6	TAOK3	3.38159937
7	ADRBK2	3.15094143
8	TLK1	3.10610071
9	WNK4	2.91177359
10	MAP3K14	2.35759086
11	FRK	1.99575544
12	NUAK1	1.81438393
13	TEC	1.78780073
14	STK39	1.67187678
15	GRK1	1.66743094
16	CDK19	1.64495227
17	GRK6	1.52345356
18	BCR	1.41928800
19	STK38L	1.40884115
20	BMPR1B	1.35414140
21	ITK	1.23436526
22	PRKCQ	1.22964106
23	PINK1	1.22883999
24	OXSR1	1.22511350
25	PIK3CA	1.21308278
26	CAMKK1	1.19762329
27	PLK2	1.10175898
28	TXK	1.09652253
29	DYRK2	1.04410217
30	MAP3K4	1.03207411
31	ADRBK1	0.97929886
32	BTK	0.93582585
33	MAP3K11	0.92627614
34	PRKCI	0.91758810
35	CSNK1G3	0.90366102
36	CDC7	0.89179231
37	CAMKK2	0.88884091
38	PRKCH	0.88784056
39	CSNK1G2	0.85950182
40	PIM2	0.85825284
41	PIM1	0.85691229
42	WNK1	0.84161431
43	NME2	0.83692242
44	MAP2K7	0.81728610
45	VRK1	0.80805201
46	PRKCG	0.80412994
47	TESK2	0.79140294
48	PDK2	0.78586429
49	GRK7	0.77863989
50	KDR	0.77245169
51	CSNK1G1	0.76862704
52	MAP2K2	0.76197107
53	PRKD3	0.73955042
54	KIT	0.73796157
55	DAPK2	0.72990173
56	PHKG2	0.72443857
57	PHKG1	0.72443857
58	MAPKAPK5	0.70959174
59	EPHA4	0.69683774
60	STK3	0.64390917
61	MAPK13	0.63766700
62	PLK1	0.61476407
63	INSRR	0.59372136
64	PRKCE	0.59108275
65	RPS6KA5	0.58878002
66	TYRO3	0.58181281
67	PAK6	0.57034678
68	VRK2	0.56321319
69	AURKA	0.54761219
70	TGFBR1	0.54052417
71	PRKACA	0.52939517
72	RPS6KA6	0.52393193
73	CSNK1A1L	0.51357570
74	MAP3K13	0.50501024
75	PAK3	0.49766955
76	DYRK1B	0.48293770
77	LIMK1	0.44150363
78	CAMK1	0.44073002
79	GRK5	0.43503457
80	OBSCN	0.41786120
81	STK24	0.40587833
82	LCK	0.40518892
83	ATR	0.40290740
84	WNK3	0.39363484
85	MAP3K5	0.39327140
86	PRKCA	0.39303775
87	CSNK1A1	0.36036196
88	JAK3	0.35188203
89	RPS6KL1	0.35091116
90	RPS6KC1	0.35091116
91	PRKCZ	0.35032959
92	FES	0.34807759
93	PLK4	0.34255293
94	CSNK2A2	0.33687772
95	CAMK2A	0.33584060
96	IGF1R	0.33087343
97	IKBKB	0.33072177
98	CDK14	0.29853817
99	LRRK2	0.29584963
100	PRKCD	0.27831784

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.85826898
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.39386920
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.03294909
4	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.86387997
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.74086458
6	Parkinsons disease_Homo sapiens_hsa05012	2.66717093
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53302030
8	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.43751458
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.06978394
10	Alzheimers disease_Homo sapiens_hsa05010	2.04416635
11	Huntingtons disease_Homo sapiens_hsa05016	1.86274249
12	Phototransduction_Homo sapiens_hsa04744	1.86235038
13	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.85477277
14	Nitrogen metabolism_Homo sapiens_hsa00910	1.83174095
15	Asthma_Homo sapiens_hsa05310	1.83094127
16	Tryptophan metabolism_Homo sapiens_hsa00380	1.77244856
17	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.73996808
18	Butanoate metabolism_Homo sapiens_hsa00650	1.65815191
19	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.56960226
20	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.55230922
21	Nicotine addiction_Homo sapiens_hsa05033	1.53746498
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.53532187
23	Retinol metabolism_Homo sapiens_hsa00830	1.33711397
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.31552679
25	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.31527624
26	Allograft rejection_Homo sapiens_hsa05330	1.29502873
27	Graft-versus-host disease_Homo sapiens_hsa05332	1.29161605
28	Peroxisome_Homo sapiens_hsa04146	1.29006294
29	Proteasome_Homo sapiens_hsa03050	1.27025647
30	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.26549043
31	Morphine addiction_Homo sapiens_hsa05032	1.25268276
32	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23089463
33	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19821325
34	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.18176753
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.15616568
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.11185779
37	RNA degradation_Homo sapiens_hsa03018	1.09755333
38	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.06774109
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.02712744
40	Primary immunodeficiency_Homo sapiens_hsa05340	0.99728168
41	Basal transcription factors_Homo sapiens_hsa03022	0.99272535
42	RNA polymerase_Homo sapiens_hsa03020	0.97356116
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.96993713
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.95423134
45	Caffeine metabolism_Homo sapiens_hsa00232	0.92303489
46	Olfactory transduction_Homo sapiens_hsa04740	0.91203938
47	Sulfur metabolism_Homo sapiens_hsa00920	0.90755304
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.90585223
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.88036525
50	Salivary secretion_Homo sapiens_hsa04970	0.85727434
51	Homologous recombination_Homo sapiens_hsa03440	0.83759117
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.82112656
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.79296331
54	Regulation of autophagy_Homo sapiens_hsa04140	0.78725615
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77442021
56	One carbon pool by folate_Homo sapiens_hsa00670	0.76676353
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75909286
58	Fatty acid degradation_Homo sapiens_hsa00071	0.74852340
59	Propanoate metabolism_Homo sapiens_hsa00640	0.74846859
60	Insulin secretion_Homo sapiens_hsa04911	0.74723869
61	Sulfur relay system_Homo sapiens_hsa04122	0.71783847
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.71719525
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70540834
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66689253
65	Serotonergic synapse_Homo sapiens_hsa04726	0.65369729
66	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64699579
67	GABAergic synapse_Homo sapiens_hsa04727	0.64693392
68	Purine metabolism_Homo sapiens_hsa00230	0.63533841
69	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.62649305
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62240222
71	Metabolic pathways_Homo sapiens_hsa01100	0.58721609
72	Fatty acid elongation_Homo sapiens_hsa00062	0.58347431
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.58330835
74	Fatty acid metabolism_Homo sapiens_hsa01212	0.58219259
75	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57895269
76	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57835572
77	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56585838
78	Antigen processing and presentation_Homo sapiens_hsa04612	0.55332138
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.55065157
80	Circadian entrainment_Homo sapiens_hsa04713	0.54661540
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.50208121
82	Glutamatergic synapse_Homo sapiens_hsa04724	0.48592451
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48564672
84	Nucleotide excision repair_Homo sapiens_hsa03420	0.46943822
85	Base excision repair_Homo sapiens_hsa03410	0.46882667
86	Basal cell carcinoma_Homo sapiens_hsa05217	0.46814556
87	Tyrosine metabolism_Homo sapiens_hsa00350	0.43327905
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.41183119
89	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40493042
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.39473316
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39455645
92	Pancreatic secretion_Homo sapiens_hsa04972	0.38225239
93	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38087743
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.37706219
95	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.36412346
96	Protein export_Homo sapiens_hsa03060	0.34735410
97	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.33643037
98	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.33575745
99	Pyruvate metabolism_Homo sapiens_hsa00620	0.33536234
100	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.33312096

RPL37P15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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