ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	8.21888738
2	viral transcription (GO:0019083)	6.73939909
3	translational termination (GO:0006415)	6.42490944
4	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.56231402
5	translational elongation (GO:0006414)	5.48095151
6	protein targeting to ER (GO:0045047)	5.47387168
7	cotranslational protein targeting to membrane (GO:0006613)	5.46741104
8	protein localization to endoplasmic reticulum (GO:0070972)	5.22977069
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.22307847
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.18514734
11	ribosomal small subunit biogenesis (GO:0042274)	5.07355362
12	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.05748281
13	ATP synthesis coupled proton transport (GO:0015986)	5.05748281
14	cellular protein complex disassembly (GO:0043624)	4.81358717
15	viral life cycle (GO:0019058)	4.77265722
16	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.67288017
17	maturation of SSU-rRNA (GO:0030490)	4.66546918
18	behavioral response to nicotine (GO:0035095)	4.51442875
19	DNA deamination (GO:0045006)	4.41448636
20	respiratory electron transport chain (GO:0022904)	4.39678070
21	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.36927228
22	electron transport chain (GO:0022900)	4.33714446
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.11290468
24	protein neddylation (GO:0045116)	4.08646686
25	protein complex disassembly (GO:0043241)	3.95203905
26	translational initiation (GO:0006413)	3.93805408
27	cytidine deamination (GO:0009972)	3.84616683
28	cytidine metabolic process (GO:0046087)	3.84616683
29	cytidine catabolic process (GO:0006216)	3.84616683
30	chaperone-mediated protein transport (GO:0072321)	3.76849734
31	protein targeting to membrane (GO:0006612)	3.76262091
32	macromolecular complex disassembly (GO:0032984)	3.70793132
33	protein complex biogenesis (GO:0070271)	3.69318201
34	response to pheromone (GO:0019236)	3.63125342
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56501499
36	NADH dehydrogenase complex assembly (GO:0010257)	3.44709086
37	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.44709086
38	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.44709086
39	translation (GO:0006412)	3.37219429
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.36087498
41	sequestering of actin monomers (GO:0042989)	3.35811160
42	positive regulation of monocyte chemotaxis (GO:0090026)	3.32844729
43	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.26186262
44	mitochondrial respiratory chain complex assembly (GO:0033108)	3.19817244
45	positive regulation of mast cell activation (GO:0033005)	3.17495976
46	hydrogen ion transmembrane transport (GO:1902600)	3.16414919
47	kynurenine metabolic process (GO:0070189)	3.12240495
48	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.05919626
49	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.99289706
50	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.96744094
51	ubiquinone biosynthetic process (GO:0006744)	2.95492130
52	ncRNA 3-end processing (GO:0043628)	2.93031913
53	positive regulation of T cell apoptotic process (GO:0070234)	2.91863092
54	regulation of cellular respiration (GO:0043457)	2.90063161
55	ATP biosynthetic process (GO:0006754)	2.89862274
56	proton transport (GO:0015992)	2.89004395
57	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.88129983
58	nonmotile primary cilium assembly (GO:0035058)	2.84920162
59	positive thymic T cell selection (GO:0045059)	2.84407307
60	indole-containing compound catabolic process (GO:0042436)	2.84026073
61	indolalkylamine catabolic process (GO:0046218)	2.84026073
62	tryptophan catabolic process (GO:0006569)	2.84026073
63	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.82719795
64	hydrogen transport (GO:0006818)	2.82340806
65	positive regulation of calcium-mediated signaling (GO:0050850)	2.81931608
66	mRNA catabolic process (GO:0006402)	2.80947352
67	actin nucleation (GO:0045010)	2.79317769
68	interferon-gamma production (GO:0032609)	2.77587218
69	pyrimidine nucleotide catabolic process (GO:0006244)	2.76556940
70	mannosylation (GO:0097502)	2.75912899
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.75713170
72	base-excision repair, AP site formation (GO:0006285)	2.74565808
73	mast cell activation involved in immune response (GO:0002279)	2.73537421
74	mast cell degranulation (GO:0043303)	2.73537421
75	GPI anchor metabolic process (GO:0006505)	2.72971328
76	ribosomal large subunit biogenesis (GO:0042273)	2.70523408
77	mast cell activation (GO:0045576)	2.66076036
78	GPI anchor biosynthetic process (GO:0006506)	2.63477434
79	T cell migration (GO:0072678)	2.63233821
80	neuron fate determination (GO:0048664)	2.62550106
81	GTP biosynthetic process (GO:0006183)	2.60101946
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.59719155
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.59719155
84	platelet dense granule organization (GO:0060155)	2.59685432
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.55981252
86	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.55774415
87	protein-cofactor linkage (GO:0018065)	2.54339261
88	ubiquinone metabolic process (GO:0006743)	2.54158219
89	negative regulation of mast cell activation (GO:0033004)	2.52579866
90	regulation of cilium movement (GO:0003352)	2.51646701
91	establishment of protein localization to membrane (GO:0090150)	2.50162375
92	positive T cell selection (GO:0043368)	2.49733543
93	tongue development (GO:0043586)	2.48522922
94	RNA catabolic process (GO:0006401)	2.47798391
95	synaptic transmission, cholinergic (GO:0007271)	2.46462236
96	cellular component biogenesis (GO:0044085)	2.46222538
97	deoxyribose phosphate catabolic process (GO:0046386)	2.45529716
98	axoneme assembly (GO:0035082)	2.44790292
99	substrate-independent telencephalic tangential migration (GO:0021826)	2.44425561
100	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.44425561

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.79792490
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.48188510
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.24415944
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.83031074
5	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.82039474
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.50843426
7	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.47893439
8	VDR_22108803_ChIP-Seq_LS180_Human	2.47579202
9	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.40317093
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.39447367
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21186852
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94621824
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.86861661
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.86575636
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.84745317
16	ZNF274_21170338_ChIP-Seq_K562_Hela	1.82319070
17	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.73589773
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.70450181
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.61802500
20	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.60358821
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.60338045
22	VDR_23849224_ChIP-Seq_CD4+_Human	1.59761123
23	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.59726793
24	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.49886398
25	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.49879434
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.49380183
27	TAF2_19829295_ChIP-Seq_ESCs_Human	1.48565250
28	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.46858832
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43849757
30	BCL6_27268052_Chip-Seq_Bcells_Human	1.43592909
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.42550709
32	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.42413307
33	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.42069984
34	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.40634431
35	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.40158553
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.39984417
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.39978713
38	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.39338953
39	IRF1_19129219_ChIP-ChIP_H3396_Human	1.38339325
40	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.35948399
41	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35477618
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.33782101
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.31347000
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.30641052
45	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.29716506
46	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.27341896
47	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26186538
48	AR_20517297_ChIP-Seq_VCAP_Human	1.22870923
49	ELK1_19687146_ChIP-ChIP_HELA_Human	1.22205764
50	NCOR_22424771_ChIP-Seq_293T_Human	1.21225228
51	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.20255824
52	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20007535
53	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.19240150
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.18436060
55	RNF2_27304074_Chip-Seq_NSC_Mouse	1.18279148
56	ERA_21632823_ChIP-Seq_H3396_Human	1.16238096
57	GATA3_26560356_Chip-Seq_TH2_Human	1.14812943
58	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13904010
59	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.13186449
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.11913208
61	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11380265
62	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.10077237
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.08218274
64	FOXP3_21729870_ChIP-Seq_TREG_Human	1.07828312
65	P53_21459846_ChIP-Seq_SAOS-2_Human	1.07746940
66	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.07701829
67	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.06716212
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.05401705
69	CIITA_25753668_ChIP-Seq_RAJI_Human	1.05080063
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04080306
71	CTCF_20526341_ChIP-Seq_ESCs_Human	1.03163852
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.02841486
73	SOX2_19829295_ChIP-Seq_ESCs_Human	1.02841486
74	SA1_27219007_Chip-Seq_Bcells_Human	1.02702795
75	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.02526379
76	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.01442308
77	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00667470
78	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.00659139
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99412855
80	IGF1R_20145208_ChIP-Seq_DFB_Human	0.99241218
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.98381573
82	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.98035594
83	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.95944732
84	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.94840536
85	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.94840536
86	P300_27268052_Chip-Seq_Bcells_Human	0.94344338
87	E2F1_20622854_ChIP-Seq_HELA_Human	0.94022575
88	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93710162
89	GATA3_27048872_Chip-Seq_THYMUS_Human	0.93518311
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.93471802
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.92742292
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92742292
93	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.91755972
94	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91607145
95	ER_23166858_ChIP-Seq_MCF-7_Human	0.91122676
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.90531926
97	MYB_26560356_Chip-Seq_TH2_Human	0.90052934
98	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.90017467
99	BCAT_22108803_ChIP-Seq_LS180_Human	0.89224071
100	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89138892

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.17845783
2	MP0006292_abnormal_olfactory_placode	3.92806045
3	MP0005671_abnormal_response_to	3.71406782
4	MP0003646_muscle_fatigue	3.12731223
5	MP0002653_abnormal_ependyma_morphology	2.53152824
6	MP0002102_abnormal_ear_morphology	2.30487185
7	MP0008789_abnormal_olfactory_epithelium	2.20945371
8	MP0001835_abnormal_antigen_presentation	2.14988914
9	MP0010386_abnormal_urinary_bladder	2.05975632
10	MP0003787_abnormal_imprinting	2.03550890
11	MP0004142_abnormal_muscle_tone	1.88692882
12	MP0002837_dystrophic_cardiac_calcinosis	1.83974942
13	MP0005646_abnormal_pituitary_gland	1.80449223
14	MP0006072_abnormal_retinal_apoptosis	1.76796064
15	MP0003011_delayed_dark_adaptation	1.76483538
16	MP0008872_abnormal_physiological_respon	1.75401071
17	MP0005551_abnormal_eye_electrophysiolog	1.75387438
18	MP0001919_abnormal_reproductive_system	1.73280656
19	MP0001986_abnormal_taste_sensitivity	1.71381647
20	MP0003724_increased_susceptibility_to	1.67604062
21	MP0003878_abnormal_ear_physiology	1.62804711
22	MP0005377_hearing/vestibular/ear_phenot	1.62804711
23	MP0008875_abnormal_xenobiotic_pharmacok	1.60964767
24	MP0005389_reproductive_system_phenotype	1.55786596
25	MP0005499_abnormal_olfactory_system	1.55254920
26	MP0005394_taste/olfaction_phenotype	1.55254920
27	MP0002163_abnormal_gland_morphology	1.54389519
28	MP0005253_abnormal_eye_physiology	1.52466353
29	MP0005257_abnormal_intraocular_pressure	1.52020230
30	MP0009785_altered_susceptibility_to	1.51885261
31	MP0004147_increased_porphyrin_level	1.47909604
32	MP0005645_abnormal_hypothalamus_physiol	1.46044668
33	MP0001800_abnormal_humoral_immune	1.44828353
34	MP0005084_abnormal_gallbladder_morpholo	1.41452449
35	MP0008877_abnormal_DNA_methylation	1.39838981
36	MP0002638_abnormal_pupillary_reflex	1.34041642
37	MP0005025_abnormal_response_to	1.31969830
38	MP0001905_abnormal_dopamine_level	1.31748337
39	MP0000685_abnormal_immune_system	1.29401947
40	MP0005000_abnormal_immune_tolerance	1.28756169
41	MP0002876_abnormal_thyroid_physiology	1.27230836
42	MP0001968_abnormal_touch/_nociception	1.24775905
43	MP0002723_abnormal_immune_serum	1.20142971
44	MP0002095_abnormal_skin_pigmentation	1.18349325
45	MP0005379_endocrine/exocrine_gland_phen	1.18021721
46	MP0006082_CNS_inflammation	1.17244664
47	MP0003880_abnormal_central_pattern	1.15961204
48	MP0002420_abnormal_adaptive_immunity	1.14392407
49	MP0002452_abnormal_antigen_presenting	1.13767777
50	MP0001819_abnormal_immune_cell	1.12312196
51	MP0002277_abnormal_respiratory_mucosa	1.12229873
52	MP0004885_abnormal_endolymph	1.12031649
53	MP0005195_abnormal_posterior_eye	1.08877194
54	MP0001984_abnormal_olfaction	1.08556559
55	MP0009764_decreased_sensitivity_to	1.07599754
56	MP0003123_paternal_imprinting	1.07048673
57	MP0001485_abnormal_pinna_reflex	1.05997114
58	MP0002148_abnormal_hypersensitivity_rea	1.04715663
59	MP0005360_urolithiasis	1.03477434
60	MP0002736_abnormal_nociception_after	1.01715971
61	MP0009333_abnormal_splenocyte_physiolog	1.01496444
62	MP0006276_abnormal_autonomic_nervous	1.00251651
63	MP0003136_yellow_coat_color	0.99701126
64	MP0002272_abnormal_nervous_system	0.98048277
65	MP0003879_abnormal_hair_cell	0.97914260
66	MP0003763_abnormal_thymus_physiology	0.97855135
67	MP0004145_abnormal_muscle_electrophysio	0.96036662
68	MP0005387_immune_system_phenotype	0.95161114
69	MP0001790_abnormal_immune_system	0.95161114
70	MP0000026_abnormal_inner_ear	0.94938613
71	MP0002160_abnormal_reproductive_system	0.94862378
72	MP0005410_abnormal_fertilization	0.94577934
73	MP0000372_irregular_coat_pigmentation	0.93733163
74	MP0001293_anophthalmia	0.93138747
75	MP0004742_abnormal_vestibular_system	0.91681653
76	MP0001873_stomach_inflammation	0.91650422
77	MP0000604_amyloidosis	0.90786117
78	MP0002933_joint_inflammation	0.90730760
79	MP0001970_abnormal_pain_threshold	0.90616074
80	MP0002419_abnormal_innate_immunity	0.89871919
81	MP0000049_abnormal_middle_ear	0.89747308
82	MP0003866_abnormal_defecation	0.86946454
83	MP0005391_vision/eye_phenotype	0.82439259
84	MP0009745_abnormal_behavioral_response	0.82399314
85	MP0003122_maternal_imprinting	0.81567734
86	MP0002234_abnormal_pharynx_morphology	0.80514548
87	MP0002733_abnormal_thermal_nociception	0.80098914
88	MP0001845_abnormal_inflammatory_respons	0.79843128
89	MP0002752_abnormal_somatic_nervous	0.78541855
90	MP0008995_early_reproductive_senescence	0.77738934
91	MP0001529_abnormal_vocalization	0.77353796
92	MP0001663_abnormal_digestive_system	0.77187076
93	MP0001963_abnormal_hearing_physiology	0.76921350
94	MP0001765_abnormal_ion_homeostasis	0.75724277
95	MP0003121_genomic_imprinting	0.75313882
96	MP0004130_abnormal_muscle_cell	0.75147684
97	MP0000716_abnormal_immune_system	0.74495173
98	MP0002557_abnormal_social/conspecific_i	0.73846193
99	MP0000631_abnormal_neuroendocrine_gland	0.71853854
100	MP0000343_altered_response_to	0.71262214

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.68142881
2	Acute necrotizing encephalopathy (HP:0006965)	4.36540816
3	Mitochondrial inheritance (HP:0001427)	4.02246657
4	Abnormal mitochondria in muscle tissue (HP:0008316)	3.95549330
5	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.88423479
6	Abnormality of cells of the erythroid lineage (HP:0012130)	3.75086279
7	Congenital stationary night blindness (HP:0007642)	3.71661252
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.62158991
9	Acute encephalopathy (HP:0006846)	3.52843907
10	Progressive macrocephaly (HP:0004481)	3.50670034
11	Elevated erythrocyte sedimentation rate (HP:0003565)	3.45199101
12	Increased CSF lactate (HP:0002490)	3.38434503
13	Hepatocellular necrosis (HP:0001404)	3.29998672
14	Vacuolated lymphocytes (HP:0001922)	3.28523001
15	Aplastic anemia (HP:0001915)	3.19834747
16	Macrocytic anemia (HP:0001972)	3.07102620
17	3-Methylglutaconic aciduria (HP:0003535)	3.03116131
18	Pancreatic fibrosis (HP:0100732)	3.03044866
19	Abnormality of glycolipid metabolism (HP:0010969)	2.98738642
20	Abnormality of liposaccharide metabolism (HP:0010968)	2.98738642
21	Abnormality of glycosphingolipid metabolism (HP:0004343)	2.98738642
22	Abnormal number of erythroid precursors (HP:0012131)	2.98324841
23	Hepatic necrosis (HP:0002605)	2.92308512
24	Increased hepatocellular lipid droplets (HP:0006565)	2.83720622
25	Type II lissencephaly (HP:0007260)	2.82421369
26	Optic disc pallor (HP:0000543)	2.80512976
27	Cerebral edema (HP:0002181)	2.78252998
28	Abnormal rod and cone electroretinograms (HP:0008323)	2.78239024
29	Abnormality of T cell number (HP:0011839)	2.72654408
30	Pancreatic cysts (HP:0001737)	2.64616434
31	True hermaphroditism (HP:0010459)	2.62399027
32	T lymphocytopenia (HP:0005403)	2.62398385
33	Abnormality of the prostate (HP:0008775)	2.58202436
34	Lipid accumulation in hepatocytes (HP:0006561)	2.57560469
35	Abnormality of midbrain morphology (HP:0002418)	2.57437438
36	Molar tooth sign on MRI (HP:0002419)	2.57437438
37	Absent/shortened dynein arms (HP:0200106)	2.55672414
38	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55672414
39	Congenital, generalized hypertrichosis (HP:0004540)	2.53870338
40	Increased intramyocellular lipid droplets (HP:0012240)	2.53105776
41	Medial flaring of the eyebrow (HP:0010747)	2.47944975
42	IgG deficiency (HP:0004315)	2.45523359
43	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.45395185
44	Prostate neoplasm (HP:0100787)	2.44994792
45	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.44406155
46	Absent thumb (HP:0009777)	2.44089296
47	Asplenia (HP:0001746)	2.42160933
48	Pallor (HP:0000980)	2.40160368
49	Recurrent gram-negative bacterial infections (HP:0005420)	2.39093019
50	Autoimmune thrombocytopenia (HP:0001973)	2.38936362
51	Cerebellar dysplasia (HP:0007033)	2.36987675
52	Abnormal respiratory motile cilium physiology (HP:0012261)	2.36063066
53	Abnormal ciliary motility (HP:0012262)	2.28260225
54	Abnormal respiratory motile cilium morphology (HP:0005938)	2.27163206
55	Abnormal respiratory epithelium morphology (HP:0012253)	2.27163206
56	Respiratory failure (HP:0002878)	2.25332797
57	Cerebral palsy (HP:0100021)	2.24268976
58	Constricted visual fields (HP:0001133)	2.23440225
59	Decreased central vision (HP:0007663)	2.23395813
60	Rib fusion (HP:0000902)	2.22206101
61	Renal Fanconi syndrome (HP:0001994)	2.21963342
62	Abolished electroretinogram (ERG) (HP:0000550)	2.19290745
63	Combined immunodeficiency (HP:0005387)	2.18839573
64	Increased IgM level (HP:0003496)	2.18664807
65	Severe combined immunodeficiency (HP:0004430)	2.17633774
66	Hypoproteinemia (HP:0003075)	2.08086045
67	Attenuation of retinal blood vessels (HP:0007843)	2.07838217
68	Increased serum lactate (HP:0002151)	2.06948187
69	Stomatitis (HP:0010280)	2.06579432
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.06247585
71	Increased muscle lipid content (HP:0009058)	2.05227178
72	Stenosis of the external auditory canal (HP:0000402)	2.02888404
73	Pendular nystagmus (HP:0012043)	2.02739477
74	Abnormality of magnesium homeostasis (HP:0004921)	2.02303815
75	Septo-optic dysplasia (HP:0100842)	2.01075572
76	Obstructive lung disease (HP:0006536)	2.00754022
77	Chronic obstructive pulmonary disease (HP:0006510)	2.00754022
78	Lactic acidosis (HP:0003128)	2.00223669
79	Congenital primary aphakia (HP:0007707)	1.98932203
80	Gait imbalance (HP:0002141)	1.97763279
81	Abnormality of T cells (HP:0002843)	1.96068097
82	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.95676642
83	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.95676642
84	Exertional dyspnea (HP:0002875)	1.93852020
85	Hypoplasia of the ulna (HP:0003022)	1.92217116
86	Lethargy (HP:0001254)	1.90291975
87	Abnormality of B cell number (HP:0010975)	1.84739674
88	Nephrogenic diabetes insipidus (HP:0009806)	1.83188160
89	Maternal diabetes (HP:0009800)	1.82769131
90	Type 2 muscle fiber atrophy (HP:0003554)	1.80359453
91	Chronic bronchitis (HP:0004469)	1.79729231
92	Anencephaly (HP:0002323)	1.78933287
93	Pancytopenia (HP:0001876)	1.78315232
94	Leukocytosis (HP:0001974)	1.78080976
95	Sclerocornea (HP:0000647)	1.77837168
96	Hyperglycinemia (HP:0002154)	1.77240689
97	Nephronophthisis (HP:0000090)	1.72854876
98	Leukodystrophy (HP:0002415)	1.69795025
99	Myokymia (HP:0002411)	1.68677775
100	Oligomenorrhea (HP:0000876)	1.68022468

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	4.03326101
2	TXK	3.66562833
3	KDR	3.25929496
4	MAP3K11	2.67206197
5	ZAK	2.61909300
6	WNK4	2.58312244
7	TLK1	2.46543817
8	CDK19	2.43256428
9	STK16	2.38634049
10	BCKDK	2.33078159
11	ADRBK2	2.27914880
12	MAP4K2	2.14673167
13	GRK1	2.12542975
14	TAOK3	2.06904453
15	MAP3K12	2.03221667
16	TIE1	1.87891167
17	LIMK1	1.86239833
18	MUSK	1.81494142
19	MAP4K1	1.80196543
20	PINK1	1.71034746
21	EPHB2	1.55092703
22	TNK2	1.52906868
23	ITK	1.49344242
24	CAMKK2	1.40602663
25	FES	1.30933072
26	PRKCH	1.27484543
27	PRKCQ	1.23117230
28	GRK7	1.18127696
29	PIK3CA	1.11837559
30	SYK	1.10235520
31	MAPK15	1.07380283
32	BLK	1.06261514
33	FRK	1.01919339
34	STK39	1.01052348
35	ZAP70	0.96682565
36	TEC	0.96670143
37	VRK2	0.95420962
38	LCK	0.95211495
39	CAMKK1	0.95044842
40	NUAK1	0.92104485
41	VRK1	0.91751542
42	BMPR1B	0.91645404
43	INSRR	0.91450812
44	CDK8	0.91262995
45	TESK1	0.90625613
46	DYRK2	0.90261289
47	WNK3	0.90126159
48	BTK	0.89829129
49	PIM2	0.88925714
50	CSK	0.86115812
51	IKBKB	0.83029856
52	TYRO3	0.81744595
53	MAPK13	0.81496116
54	DAPK3	0.78555378
55	PIK3CG	0.78258401
56	RPS6KA5	0.74861219
57	OXSR1	0.74520779
58	SCYL2	0.73354395
59	CAMK1	0.71640538
60	ABL2	0.70670595
61	LYN	0.70586895
62	PASK	0.70578427
63	PIM1	0.70151872
64	GRK6	0.69967117
65	ADRBK1	0.69655655
66	PLK4	0.68392534
67	BMPR2	0.67816699
68	DAPK1	0.65697359
69	MYLK	0.64715377
70	IKBKE	0.63529883
71	AURKA	0.61686012
72	ARAF	0.60627816
73	MAP2K7	0.58728854
74	OBSCN	0.57997584
75	CDK3	0.56615376
76	LRRK2	0.56391906
77	NTRK2	0.55869503
78	PRKACA	0.54677214
79	RPS6KA6	0.54525339
80	DYRK1B	0.54442862
81	ILK	0.53885731
82	NLK	0.53820011
83	PRKCD	0.51988104
84	PRKCG	0.51505636
85	MAP2K2	0.50426092
86	EPHA4	0.49932020
87	CSF1R	0.49676166
88	PRKCA	0.43951620
89	PKN1	0.40175958
90	AURKB	0.39115663
91	CSNK1G1	0.38245956
92	CAMK2A	0.36630202
93	MAP2K6	0.36357116
94	CSNK2A2	0.36193849
95	STK11	0.35587013
96	IGF1R	0.35320341
97	RPS6KA4	0.35042909
98	RPS6KL1	0.34774474
99	RPS6KC1	0.34774474
100	CSNK2A1	0.34518591

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.10398985
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.26200399
3	Parkinsons disease_Homo sapiens_hsa05012	3.62654329
4	Asthma_Homo sapiens_hsa05310	3.11882706
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.96614515
6	Allograft rejection_Homo sapiens_hsa05330	2.96209990
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.95549027
8	Primary immunodeficiency_Homo sapiens_hsa05340	2.81011073
9	Alzheimers disease_Homo sapiens_hsa05010	2.42875663
10	Proteasome_Homo sapiens_hsa03050	2.35794017
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.35261129
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.32938314
13	Huntingtons disease_Homo sapiens_hsa05016	2.28993832
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.25833026
15	RNA polymerase_Homo sapiens_hsa03020	2.24638960
16	Cardiac muscle contraction_Homo sapiens_hsa04260	2.23553091
17	Antigen processing and presentation_Homo sapiens_hsa04612	2.21512782
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.93924613
19	Phototransduction_Homo sapiens_hsa04744	1.78243355
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74023215
21	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.69579081
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.57048899
23	Viral myocarditis_Homo sapiens_hsa05416	1.43852914
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41251199
25	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.33353595
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.26923564
27	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.22847283
28	Protein export_Homo sapiens_hsa03060	1.21878466
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.19064730
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13557886
31	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.11353204
32	Caffeine metabolism_Homo sapiens_hsa00232	1.08918690
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.07812360
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.05987458
35	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.03226724
36	Olfactory transduction_Homo sapiens_hsa04740	0.96644493
37	Leishmaniasis_Homo sapiens_hsa05140	0.93949221
38	Ether lipid metabolism_Homo sapiens_hsa00565	0.92846105
39	Malaria_Homo sapiens_hsa05144	0.86944665
40	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.86319627
41	Homologous recombination_Homo sapiens_hsa03440	0.83652604
42	Peroxisome_Homo sapiens_hsa04146	0.82647311
43	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.82158578
44	Basal transcription factors_Homo sapiens_hsa03022	0.78440409
45	Collecting duct acid secretion_Homo sapiens_hsa04966	0.75913741
46	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74744757
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.71414381
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.71067246
49	Nicotine addiction_Homo sapiens_hsa05033	0.70510378
50	Phagosome_Homo sapiens_hsa04145	0.64336950
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.63916851
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.63401836
53	Fat digestion and absorption_Homo sapiens_hsa04975	0.60990450
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.59599553
55	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.58675105
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.58450018
57	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.58286030
58	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56644293
59	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56187548
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.56054128
61	RNA degradation_Homo sapiens_hsa03018	0.55882842
62	Sulfur relay system_Homo sapiens_hsa04122	0.52822968
63	Retinol metabolism_Homo sapiens_hsa00830	0.51507992
64	Purine metabolism_Homo sapiens_hsa00230	0.50782136
65	Butanoate metabolism_Homo sapiens_hsa00650	0.49843426
66	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.49815483
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.47924162
68	Taste transduction_Homo sapiens_hsa04742	0.46895633
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46662959
70	Metabolic pathways_Homo sapiens_hsa01100	0.45207010
71	Morphine addiction_Homo sapiens_hsa05032	0.41995817
72	Lysosome_Homo sapiens_hsa04142	0.41261624
73	Fanconi anemia pathway_Homo sapiens_hsa03460	0.40840045
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.38882370
75	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.35980730
76	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.34854774
77	One carbon pool by folate_Homo sapiens_hsa00670	0.34010981
78	Tuberculosis_Homo sapiens_hsa05152	0.32079257
79	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.30465296
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28037285
81	Legionellosis_Homo sapiens_hsa05134	0.27851474
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.27171698
83	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.26593465
84	Glycerolipid metabolism_Homo sapiens_hsa00561	0.24237706
85	Regulation of autophagy_Homo sapiens_hsa04140	0.24146772
86	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.23325324
87	Salivary secretion_Homo sapiens_hsa04970	0.21076569
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.20750861
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.19209295
90	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.18292558
91	Propanoate metabolism_Homo sapiens_hsa00640	0.18274235
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.16901350
93	Mineral absorption_Homo sapiens_hsa04978	0.16483561
94	Pertussis_Homo sapiens_hsa05133	0.15584678
95	Measles_Homo sapiens_hsa05162	0.14508457
96	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.12691407
97	African trypanosomiasis_Homo sapiens_hsa05143	0.12017441
98	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.11801220
99	Salmonella infection_Homo sapiens_hsa05132	0.11754514
100	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.10553052

RPL37P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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