RPL37P23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.93071599
2viral transcription (GO:0019083)8.99518516
3translational termination (GO:0006415)8.56893822
4ribosomal small subunit biogenesis (GO:0042274)8.34529375
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.23339254
6translational elongation (GO:0006414)7.16971797
7cotranslational protein targeting to membrane (GO:0006613)7.11021255
8protein targeting to ER (GO:0045047)7.08823224
9establishment of protein localization to endoplasmic reticulum (GO:0072599)6.74690745
10protein localization to endoplasmic reticulum (GO:0070972)6.71878268
11viral life cycle (GO:0019058)6.59045187
12cellular protein complex disassembly (GO:0043624)6.50551750
13nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.45711166
14maturation of SSU-rRNA (GO:0030490)6.26057617
15ATP synthesis coupled proton transport (GO:0015986)6.13885916
16energy coupled proton transport, down electrochemical gradient (GO:0015985)6.13885916
17chaperone-mediated protein transport (GO:0072321)5.48782350
18protein complex disassembly (GO:0043241)5.42155884
19translational initiation (GO:0006413)5.41016392
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.36180905
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.23133806
22macromolecular complex disassembly (GO:0032984)5.06531279
23protein targeting to membrane (GO:0006612)4.79452395
24respiratory electron transport chain (GO:0022904)4.63499875
25electron transport chain (GO:0022900)4.56092270
26translation (GO:0006412)4.46309550
27nuclear-transcribed mRNA catabolic process (GO:0000956)4.42878353
28mRNA catabolic process (GO:0006402)4.15963600
29ribosomal large subunit biogenesis (GO:0042273)4.10734262
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.10037382
31mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.09858839
32mitochondrial respiratory chain complex I assembly (GO:0032981)4.09858839
33NADH dehydrogenase complex assembly (GO:0010257)4.09858839
34DNA deamination (GO:0045006)4.08470467
35behavioral response to nicotine (GO:0035095)4.06669834
36protein complex biogenesis (GO:0070271)4.02847697
37pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.95296802
38protein neddylation (GO:0045116)3.92839224
39ATP biosynthetic process (GO:0006754)3.83529183
40RNA catabolic process (GO:0006401)3.75468507
41phosphatidylinositol acyl-chain remodeling (GO:0036149)3.74212120
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.70955138
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.60188232
44phosphatidylserine acyl-chain remodeling (GO:0036150)3.60148969
45mitochondrial respiratory chain complex assembly (GO:0033108)3.60096289
46cellular component biogenesis (GO:0044085)3.50862439
47ribonucleoprotein complex biogenesis (GO:0022613)3.44910626
48pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32857799
49GTP biosynthetic process (GO:0006183)3.31137326
50ncRNA 3-end processing (GO:0043628)3.30952989
51pyrimidine nucleotide catabolic process (GO:0006244)3.26594820
52ribonucleoside triphosphate biosynthetic process (GO:0009201)3.19891552
53establishment of protein localization to membrane (GO:0090150)3.19636658
54nonmotile primary cilium assembly (GO:0035058)3.05302708
55protein targeting (GO:0006605)3.03764225
56hydrogen ion transmembrane transport (GO:1902600)3.03375975
57activated T cell proliferation (GO:0050798)2.98725395
58protein polyglutamylation (GO:0018095)2.94187909
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.90531111
60RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.90531111
61termination of RNA polymerase III transcription (GO:0006386)2.90129795
62transcription elongation from RNA polymerase III promoter (GO:0006385)2.90129795
63phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.85094434
64cell proliferation in forebrain (GO:0021846)2.83528575
65nucleoside triphosphate biosynthetic process (GO:0009142)2.77539451
66establishment of protein localization to organelle (GO:0072594)2.76877754
67protein localization to membrane (GO:0072657)2.76392374
68proton transport (GO:0015992)2.76383753
69UTP biosynthetic process (GO:0006228)2.75002112
70pseudouridine synthesis (GO:0001522)2.74823605
71protein-cofactor linkage (GO:0018065)2.71337965
72establishment of mitochondrion localization (GO:0051654)2.70805634
73hydrogen transport (GO:0006818)2.70057561
74rRNA metabolic process (GO:0016072)2.64336910
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.63366290
76modulation by virus of host process (GO:0019054)2.62523573
77phosphatidylcholine acyl-chain remodeling (GO:0036151)2.61309457
78mitochondrion transport along microtubule (GO:0047497)2.59725629
79establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.59725629
80exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58091852
81negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.56763367
82deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56440225
83regulation of cilium movement (GO:0003352)2.55523021
84substrate-independent telencephalic tangential migration (GO:0021826)2.54827124
85substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.54827124
86intracellular protein transmembrane import (GO:0044743)2.53380676
87UTP metabolic process (GO:0046051)2.52886805
88cardiovascular system development (GO:0072358)2.50849317
89rRNA processing (GO:0006364)2.49507960
90positive regulation of respiratory burst (GO:0060267)2.47464576
91piRNA metabolic process (GO:0034587)2.46788594
92leukocyte aggregation (GO:0070486)2.45685457
93pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.42778251
94cytidine metabolic process (GO:0046087)2.40946132
95cytidine catabolic process (GO:0006216)2.40946132
96cytidine deamination (GO:0009972)2.40946132
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.40569381
98negative regulation of appetite (GO:0032099)2.39517639
99negative regulation of response to food (GO:0032096)2.39517639
100pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.38033093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.37012893
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.99583949
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.39920924
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10996801
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.74375708
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.60900963
7VDR_22108803_ChIP-Seq_LS180_Human2.53585243
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.45948790
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.31827971
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.31202657
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.26589315
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.25915826
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18692741
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10145621
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.09629387
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04253518
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.00704872
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.96819517
19CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91281840
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87536266
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84193417
22JARID2_20064375_ChIP-Seq_MESCs_Mouse1.81499354
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.80778880
24YY1_21170310_ChIP-Seq_MESCs_Mouse1.73639770
25CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.69840776
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.66689226
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.66104968
28SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60544674
29CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59443850
30TAF2_19829295_ChIP-Seq_ESCs_Human1.53741474
31JARID2_20075857_ChIP-Seq_MESCs_Mouse1.52807832
32TP53_22573176_ChIP-Seq_HFKS_Human1.45990947
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.44059629
34ZNF274_21170338_ChIP-Seq_K562_Hela1.41854164
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40019728
36XRN2_22483619_ChIP-Seq_HELA_Human1.38087753
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.34337067
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.33202754
39VDR_23849224_ChIP-Seq_CD4+_Human1.33105680
40ERA_21632823_ChIP-Seq_H3396_Human1.33029329
41TTF2_22483619_ChIP-Seq_HELA_Human1.32944278
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31676782
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31094948
44CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26926466
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26876954
46EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26834692
47BCL6_27268052_Chip-Seq_Bcells_Human1.26549623
48RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26345919
49AUTS2_25519132_ChIP-Seq_293T-REX_Human1.25711592
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24226901
51RNF2_27304074_Chip-Seq_NSC_Mouse1.23438008
52SA1_27219007_Chip-Seq_Bcells_Human1.23001911
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22607988
54PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.21039925
55SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19060198
56REST_21632747_ChIP-Seq_MESCs_Mouse1.18466755
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.18370290
58SOX2_21211035_ChIP-Seq_LN229_Human1.16843173
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14707285
60SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.14370336
61CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13225417
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.13186362
63FOXP3_21729870_ChIP-Seq_TREG_Human1.13033514
64PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11217517
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.10703422
66NANOG_20526341_ChIP-Seq_ESCs_Human1.09117197
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08707377
68EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08673849
69RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08673849
70SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07634739
71P53_21459846_ChIP-Seq_SAOS-2_Human1.07557748
72MYC_19829295_ChIP-Seq_ESCs_Human1.06405017
73CTCF_20526341_ChIP-Seq_ESCs_Human1.05746046
74E2F1_20622854_ChIP-Seq_HELA_Human1.04513839
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02938789
76IRF1_19129219_ChIP-ChIP_H3396_Human1.02806707
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.02539339
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02253815
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02131549
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.01274650
81EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.01196978
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01073041
83AR_20517297_ChIP-Seq_VCAP_Human1.00974752
84SRF_21415370_ChIP-Seq_HL-1_Mouse0.99962673
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99398884
86SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98979984
87FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98458214
88FOXA1_25329375_ChIP-Seq_VCAP_Human0.98458214
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97485755
90MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97334759
91CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97195627
92GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96773200
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.95028447
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94642130
95GATA3_21867929_ChIP-Seq_TH1_Mouse0.94402155
96MYC_18940864_ChIP-ChIP_HL60_Human0.93695750
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93625097
98STAT1_20625510_ChIP-Seq_HELA_Human0.91944106
99FOXH1_21741376_ChIP-Seq_ESCs_Human0.91060979
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90208710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation7.57532627
2MP0006292_abnormal_olfactory_placode3.43671056
3MP0003646_muscle_fatigue2.94660540
4MP0004145_abnormal_muscle_electrophysio2.50730188
5MP0004885_abnormal_endolymph2.38981670
6MP0002163_abnormal_gland_morphology2.35530978
7MP0005377_hearing/vestibular/ear_phenot2.28988838
8MP0003878_abnormal_ear_physiology2.28988838
9MP0008877_abnormal_DNA_methylation2.12103899
10MP0004142_abnormal_muscle_tone2.11521106
11MP0005671_abnormal_response_to2.03201455
12MP0002653_abnormal_ependyma_morphology1.96581684
13MP0005646_abnormal_pituitary_gland1.93963716
14MP0003136_yellow_coat_color1.84726988
15MP0001529_abnormal_vocalization1.83683122
16MP0001485_abnormal_pinna_reflex1.79042458
17MP0003122_maternal_imprinting1.78683192
18MP0008789_abnormal_olfactory_epithelium1.73888737
19MP0005551_abnormal_eye_electrophysiolog1.73431356
20MP0000750_abnormal_muscle_regeneration1.63626486
21MP0003787_abnormal_imprinting1.61997873
22MP0002837_dystrophic_cardiac_calcinosis1.61733052
23MP0000049_abnormal_middle_ear1.59226535
24MP0002277_abnormal_respiratory_mucosa1.53156405
25MP0003011_delayed_dark_adaptation1.48571512
26MP0003195_calcinosis1.46349321
27MP0003879_abnormal_hair_cell1.46060604
28MP0002638_abnormal_pupillary_reflex1.43823801
29MP0001905_abnormal_dopamine_level1.40626859
30MP0006276_abnormal_autonomic_nervous1.34126873
31MP0000631_abnormal_neuroendocrine_gland1.33739717
32MP0005379_endocrine/exocrine_gland_phen1.33429960
33MP0005394_taste/olfaction_phenotype1.31175007
34MP0005499_abnormal_olfactory_system1.31175007
35MP0002102_abnormal_ear_morphology1.29767168
36MP0006072_abnormal_retinal_apoptosis1.28642091
37MP0008872_abnormal_physiological_respon1.28628656
38MP0000566_synostosis1.27934311
39MP0001440_abnormal_grooming_behavior1.26646947
40MP0002160_abnormal_reproductive_system1.24958201
41MP0001727_abnormal_embryo_implantation1.24929641
42MP0002876_abnormal_thyroid_physiology1.23740073
43MP0005389_reproductive_system_phenotype1.22508854
44MP0001986_abnormal_taste_sensitivity1.19199163
45MP0002095_abnormal_skin_pigmentation1.19120020
46MP0004742_abnormal_vestibular_system1.19044780
47MP0009046_muscle_twitch1.17118069
48MP0005195_abnormal_posterior_eye1.16483433
49MP0005645_abnormal_hypothalamus_physiol1.15545440
50MP0001919_abnormal_reproductive_system1.15294818
51MP0002272_abnormal_nervous_system1.14203368
52MP0004858_abnormal_nervous_system1.14019557
53MP0008875_abnormal_xenobiotic_pharmacok1.12415719
54MP0001835_abnormal_antigen_presentation1.11245577
55MP0001486_abnormal_startle_reflex1.09841104
56MP0003121_genomic_imprinting1.09120472
57MP0001968_abnormal_touch/_nociception1.07518844
58MP0003123_paternal_imprinting1.07341089
59MP0000026_abnormal_inner_ear1.06078135
60MP0005623_abnormal_meninges_morphology1.04165867
61MP0002736_abnormal_nociception_after1.02380024
62MP0009053_abnormal_anal_canal1.02265085
63MP0002938_white_spotting1.02115595
64MP0002933_joint_inflammation1.01905395
65MP0003938_abnormal_ear_development1.01123250
66MP0002752_abnormal_somatic_nervous1.00234032
67MP0009745_abnormal_behavioral_response0.96321137
68MP0004147_increased_porphyrin_level0.94112552
69MP0005423_abnormal_somatic_nervous0.92711059
70MP0002184_abnormal_innervation0.91950192
71MP0001963_abnormal_hearing_physiology0.91046376
72MP0000778_abnormal_nervous_system0.86239969
73MP0000955_abnormal_spinal_cord0.85306088
74MP0003567_abnormal_fetal_cardiomyocyte0.85059430
75MP0005253_abnormal_eye_physiology0.85053544
76MP0009250_abnormal_appendicular_skeleto0.84597215
77MP0001293_anophthalmia0.83950863
78MP0003186_abnormal_redox_activity0.83929101
79MP0002138_abnormal_hepatobiliary_system0.79045775
80MP0002557_abnormal_social/conspecific_i0.78446293
81MP0003137_abnormal_impulse_conducting0.75525495
82MP0004924_abnormal_behavior0.74206982
83MP0005386_behavior/neurological_phenoty0.74206982
84MP0002210_abnormal_sex_determination0.73117576
85MP0008995_early_reproductive_senescence0.72507845
86MP0006036_abnormal_mitochondrial_physio0.71670388
87MP0009384_cardiac_valve_regurgitation0.70605888
88MP0002572_abnormal_emotion/affect_behav0.69085617
89MP0008775_abnormal_heart_ventricle0.67839663
90MP0001348_abnormal_lacrimal_gland0.67540393
91MP0003786_premature_aging0.67270688
92MP0001970_abnormal_pain_threshold0.66754157
93MP0001800_abnormal_humoral_immune0.66193211
94MP0003866_abnormal_defecation0.66141149
95MP0000230_abnormal_systemic_arterial0.64103673
96MP0003635_abnormal_synaptic_transmissio0.63512799
97MP0009785_altered_susceptibility_to0.62902045
98MP0002229_neurodegeneration0.62063441
99MP0002067_abnormal_sensory_capabilities0.61809842
100MP0005084_abnormal_gallbladder_morpholo0.61628287

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.18456321
2Abnormal mitochondria in muscle tissue (HP:0008316)4.64028679
3Type II lissencephaly (HP:0007260)4.24324382
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.22137659
5Cerebellar dysplasia (HP:0007033)4.17997067
6Mitochondrial inheritance (HP:0001427)4.16301759
7Progressive macrocephaly (HP:0004481)4.14457030
8Acute encephalopathy (HP:0006846)4.14356579
9Abnormality of cells of the erythroid lineage (HP:0012130)4.11329073
10Reticulocytopenia (HP:0001896)4.05604132
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.64720923
12Pallor (HP:0000980)3.64452603
13Increased CSF lactate (HP:0002490)3.43579196
14Increased hepatocellular lipid droplets (HP:0006565)3.41531116
15Renal Fanconi syndrome (HP:0001994)3.41036451
16Macrocytic anemia (HP:0001972)3.30839529
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26351881
18Abnormal number of erythroid precursors (HP:0012131)3.24969535
19Lipid accumulation in hepatocytes (HP:0006561)3.23494297
20Cerebral edema (HP:0002181)3.21177536
21Increased IgM level (HP:0003496)3.11660824
22Retinal atrophy (HP:0001105)3.06049737
23Pendular nystagmus (HP:0012043)2.99929138
24Decreased electroretinogram (ERG) amplitude (HP:0000654)2.95016692
25Abnormal rod and cone electroretinograms (HP:0008323)2.94363720
26Hepatocellular necrosis (HP:0001404)2.92219037
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.83127128
28Abolished electroretinogram (ERG) (HP:0000550)2.83101400
293-Methylglutaconic aciduria (HP:0003535)2.78539952
30Optic disc pallor (HP:0000543)2.78538826
31Retinal dysplasia (HP:0007973)2.77740590
32Elevated erythrocyte sedimentation rate (HP:0003565)2.68056694
33Hepatic necrosis (HP:0002605)2.61368704
34Agnosia (HP:0010524)2.55178563
35Aplasia/Hypoplasia of the spleen (HP:0010451)2.54503405
36Asplenia (HP:0001746)2.53614367
37Decreased central vision (HP:0007663)2.52051827
38Partial duplication of thumb phalanx (HP:0009944)2.48208054
39Increased intramyocellular lipid droplets (HP:0012240)2.44800076
40True hermaphroditism (HP:0010459)2.40378213
41Exertional dyspnea (HP:0002875)2.37180743
42Septo-optic dysplasia (HP:0100842)2.37148909
43Abnormality of DNA repair (HP:0003254)2.33679571
44Absent thumb (HP:0009777)2.33105167
45Molar tooth sign on MRI (HP:0002419)2.32097598
46Abnormality of midbrain morphology (HP:0002418)2.32097598
47Congenital stationary night blindness (HP:0007642)2.31736106
48Abnormality of renal resorption (HP:0011038)2.29734498
49Congenital, generalized hypertrichosis (HP:0004540)2.24613102
50Partial duplication of the phalanx of hand (HP:0009999)2.24419838
51Papilledema (HP:0001085)2.23650245
52Stenosis of the external auditory canal (HP:0000402)2.22104636
53Hypoplasia of the pons (HP:0012110)2.20269656
54Maternal diabetes (HP:0009800)2.19369882
55Disinhibition (HP:0000734)2.19346388
56Pancreatic fibrosis (HP:0100732)2.19048289
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18073490
58Aplasia/Hypoplasia affecting the retina (HP:0008061)2.16428219
59IgG deficiency (HP:0004315)2.14993952
60Increased muscle lipid content (HP:0009058)2.11155157
61Attenuation of retinal blood vessels (HP:0007843)2.10076511
62Pancreatic cysts (HP:0001737)2.09887325
63Type 2 muscle fiber atrophy (HP:0003554)2.09649410
64Chronic bronchitis (HP:0004469)2.08502543
65Hypoplasia of the radius (HP:0002984)2.08440737
66Leukodystrophy (HP:0002415)2.07663721
67Abnormality of magnesium homeostasis (HP:0004921)2.02971761
68Hyperphosphaturia (HP:0003109)2.01634575
69Severe muscular hypotonia (HP:0006829)2.01282985
70Keratoconus (HP:0000563)2.01082906
71Increased corneal curvature (HP:0100692)2.01082906
72Anencephaly (HP:0002323)2.00640007
73Nephronophthisis (HP:0000090)2.00440372
74Muscle fiber atrophy (HP:0100295)1.99627039
75Abnormality of the pons (HP:0007361)1.95207364
76Sclerocornea (HP:0000647)1.92643068
77Respiratory failure (HP:0002878)1.90249108
78Abnormal hemoglobin (HP:0011902)1.87623111
79Medial flaring of the eyebrow (HP:0010747)1.87502752
80Respiratory difficulties (HP:0002880)1.83408495
81Pachygyria (HP:0001302)1.83374158
82Recurrent gram-negative bacterial infections (HP:0005420)1.81826745
83Hypoplasia of the ulna (HP:0003022)1.81553332
84Abnormality of the middle phalanges of the toes (HP:0010183)1.77793074
85Increased serum lactate (HP:0002151)1.77304660
86Polyphagia (HP:0002591)1.77062858
87Lissencephaly (HP:0001339)1.76637221
88Rib fusion (HP:0000902)1.74957754
89Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73411748
90Lactic acidosis (HP:0003128)1.72214004
91Forearm undergrowth (HP:0009821)1.70707199
92Myokymia (HP:0002411)1.70202600
93Aplasia/Hypoplasia of the ulna (HP:0006495)1.69246661
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.67514456
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.67514456
96Exercise intolerance (HP:0003546)1.66995908
97Abnormal respiratory motile cilium physiology (HP:0012261)1.66759659
9811 pairs of ribs (HP:0000878)1.66754361
99Glycosuria (HP:0003076)1.65221902
100Abnormality of urine glucose concentration (HP:0011016)1.65221902

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.09722598
2NME23.02929565
3MARK33.00582126
4TXK2.56746649
5PRKCH2.54779875
6CDK192.52511226
7WNK42.36461206
8MAP4K12.33825218
9DYRK22.29630143
10ADRBK21.94850050
11PIK3CA1.87792620
12STK161.82734580
13WNK31.80759914
14TIE11.75362591
15KDR1.74169803
16STK101.72712011
17GRK11.63673738
18LIMK11.58462778
19ZAK1.48463906
20PINK11.46766750
21PIM11.41602130
22TLK11.37047471
23LRRK21.36167762
24STK111.35755517
25PRKCQ1.18739472
26ABL21.15996015
27INSRR1.11591581
28EPHB21.09654521
29GRK61.06680864
30MAP4K21.05805175
31ADRBK11.05639136
32TAOK31.03904504
33EIF2AK11.01119792
34MAP3K111.00488386
35LCK0.98869896
36CAMKK20.98122060
37NTRK20.96521606
38SYK0.93770889
39PRKCG0.92244024
40OBSCN0.91074092
41MAPK130.89762982
42MAP3K40.89545442
43CDC70.88901353
44CAMK10.86189169
45PRKACA0.86050142
46RPS6KA60.85672835
47DYRK1B0.85008225
48FRK0.84332712
49STK390.84284747
50PHKG20.84252882
51PHKG10.84252882
52TYRO30.82419768
53CASK0.78160122
54CSNK2A20.77752189
55RPS6KA50.76094746
56FES0.72914019
57IKBKB0.71496811
58EPHA30.69847569
59DAPK30.69187689
60PTK2B0.67289160
61CSNK1G20.66904421
62PIM20.66608932
63NME10.66065458
64CAMKK10.65297722
65DYRK1A0.65257158
66CSNK1G30.64324670
67RPS6KC10.64306387
68RPS6KL10.64306387
69WNK10.63611285
70AURKA0.63402617
71CAMK2A0.63305775
72MAP3K90.63047414
73TEC0.62150163
74PBK0.60998661
75PLK40.59261305
76PRKCA0.58222845
77MINK10.57587852
78PRKCD0.57190945
79LYN0.56781983
80ARAF0.56588183
81NUAK10.54248012
82AURKB0.54060402
83MAP3K120.53863696
84OXSR10.52204356
85MUSK0.52034452
86CSNK2A10.51288326
87GRK70.49193688
88PKN10.48748192
89RIPK40.45470985
90CSK0.45287474
91CSNK1A10.45270948
92PDK20.45235563
93MARK10.45005876
94RPS6KA20.44682092
95ERBB20.43212206
96PRKACG0.42764112
97NEK20.41962857
98ILK0.41318716
99MYLK0.41263464
100CDK11A0.40415584

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.79872661
2Oxidative phosphorylation_Homo sapiens_hsa001904.53162284
3Parkinsons disease_Homo sapiens_hsa050123.91164565
4RNA polymerase_Homo sapiens_hsa030203.22945863
5Huntingtons disease_Homo sapiens_hsa050162.75372210
6Alzheimers disease_Homo sapiens_hsa050102.73857920
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.70324343
8Cardiac muscle contraction_Homo sapiens_hsa042602.65859867
9Linoleic acid metabolism_Homo sapiens_hsa005912.51464242
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.37994085
11Graft-versus-host disease_Homo sapiens_hsa053322.13028010
12Allograft rejection_Homo sapiens_hsa053302.07798852
13Autoimmune thyroid disease_Homo sapiens_hsa053202.05403441
14Sulfur relay system_Homo sapiens_hsa041221.99301218
15Asthma_Homo sapiens_hsa053101.81193702
16Proteasome_Homo sapiens_hsa030501.69994508
17Primary immunodeficiency_Homo sapiens_hsa053401.64057538
18Type I diabetes mellitus_Homo sapiens_hsa049401.63243998
19Protein export_Homo sapiens_hsa030601.49134538
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45378663
21Pyrimidine metabolism_Homo sapiens_hsa002401.44446845
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.37465794
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.33842980
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27538018
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22952783
26Viral myocarditis_Homo sapiens_hsa054161.21785177
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12104383
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06928122
29Arachidonic acid metabolism_Homo sapiens_hsa005901.06220008
30Phototransduction_Homo sapiens_hsa047441.05526641
31Ether lipid metabolism_Homo sapiens_hsa005651.04396447
32RNA degradation_Homo sapiens_hsa030181.01330476
33Nitrogen metabolism_Homo sapiens_hsa009101.00676838
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97640944
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93790271
36Purine metabolism_Homo sapiens_hsa002300.92156817
37Rheumatoid arthritis_Homo sapiens_hsa053230.90834627
38Nicotine addiction_Homo sapiens_hsa050330.87510398
39Nucleotide excision repair_Homo sapiens_hsa034200.87428893
40SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85706294
41Malaria_Homo sapiens_hsa051440.81203241
42Olfactory transduction_Homo sapiens_hsa047400.80937055
43One carbon pool by folate_Homo sapiens_hsa006700.80130951
44Staphylococcus aureus infection_Homo sapiens_hsa051500.79403113
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79074867
46Chemical carcinogenesis_Homo sapiens_hsa052040.77863766
47Fat digestion and absorption_Homo sapiens_hsa049750.76249513
48Antigen processing and presentation_Homo sapiens_hsa046120.76083849
49Collecting duct acid secretion_Homo sapiens_hsa049660.75176593
50Caffeine metabolism_Homo sapiens_hsa002320.69508590
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64296800
52Hematopoietic cell lineage_Homo sapiens_hsa046400.64010451
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.59470661
54Homologous recombination_Homo sapiens_hsa034400.54911639
55Metabolic pathways_Homo sapiens_hsa011000.54634000
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54121956
57Morphine addiction_Homo sapiens_hsa050320.52965662
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.52590392
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51266895
60Leishmaniasis_Homo sapiens_hsa051400.49009286
61Basal transcription factors_Homo sapiens_hsa030220.48422957
62Retinol metabolism_Homo sapiens_hsa008300.46716545
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.46386438
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45934069
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.45925508
66Peroxisome_Homo sapiens_hsa041460.45858918
67Fanconi anemia pathway_Homo sapiens_hsa034600.45229420
68RNA transport_Homo sapiens_hsa030130.44165608
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.43501560
70Spliceosome_Homo sapiens_hsa030400.43031392
71Sulfur metabolism_Homo sapiens_hsa009200.41907587
72DNA replication_Homo sapiens_hsa030300.41501260
73Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40960677
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40945866
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40702877
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38891789
77Systemic lupus erythematosus_Homo sapiens_hsa053220.38634567
78Base excision repair_Homo sapiens_hsa034100.38363519
79Glycerophospholipid metabolism_Homo sapiens_hsa005640.37982830
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35731328
81Regulation of autophagy_Homo sapiens_hsa041400.31093668
82Phagosome_Homo sapiens_hsa041450.30950342
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.30902311
84Tryptophan metabolism_Homo sapiens_hsa003800.30257572
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.29579976
86Butanoate metabolism_Homo sapiens_hsa006500.29229973
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28131269
88Glycerolipid metabolism_Homo sapiens_hsa005610.26600349
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.26244923
90Insulin secretion_Homo sapiens_hsa049110.25124220
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.24245943
92Basal cell carcinoma_Homo sapiens_hsa052170.24123149
93Tyrosine metabolism_Homo sapiens_hsa003500.23722245
94Taste transduction_Homo sapiens_hsa047420.23599484
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23512264
96Serotonergic synapse_Homo sapiens_hsa047260.21832696
97Hedgehog signaling pathway_Homo sapiens_hsa043400.21540511
98Ras signaling pathway_Homo sapiens_hsa040140.19405618
99GABAergic synapse_Homo sapiens_hsa047270.18723357
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.16212093

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