RPL37P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)9.51973057
2viral transcription (GO:0019083)9.40130677
3translational termination (GO:0006415)8.95151248
4ribosomal small subunit assembly (GO:0000028)7.76772142
5translational elongation (GO:0006414)7.53508853
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)7.40557175
7cotranslational protein targeting to membrane (GO:0006613)7.29307184
8maturation of SSU-rRNA (GO:0030490)7.25448765
9protein targeting to ER (GO:0045047)7.24403659
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.96504942
11viral life cycle (GO:0019058)6.84297721
12cellular protein complex disassembly (GO:0043624)6.79843998
13protein localization to endoplasmic reticulum (GO:0070972)6.75600685
14energy coupled proton transport, down electrochemical gradient (GO:0015985)6.53391860
15ATP synthesis coupled proton transport (GO:0015986)6.53391860
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)6.53336209
17chaperone-mediated protein transport (GO:0072321)6.52084995
18protein complex disassembly (GO:0043241)5.76378074
19translational initiation (GO:0006413)5.71186556
20macromolecular complex disassembly (GO:0032984)5.42402405
21ribosomal large subunit biogenesis (GO:0042273)5.03442092
22protein targeting to membrane (GO:0006612)5.02462911
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.88621589
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.81718953
25behavioral response to nicotine (GO:0035095)4.69652700
26nuclear-transcribed mRNA catabolic process (GO:0000956)4.63211457
27translation (GO:0006412)4.60387071
28ribonucleoprotein complex biogenesis (GO:0022613)4.40946050
29mRNA catabolic process (GO:0006402)4.37538673
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37339237
31protein neddylation (GO:0045116)4.33601282
32cellular component biogenesis (GO:0044085)4.22585458
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.18312494
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.18312494
35ATP biosynthetic process (GO:0006754)4.03919804
36pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.92174801
37RNA catabolic process (GO:0006401)3.90334099
38respiratory electron transport chain (GO:0022904)3.86115077
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84662132
40electron transport chain (GO:0022900)3.83952198
41substrate-independent telencephalic tangential migration (GO:0021826)3.79418659
42substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.79418659
43protein complex biogenesis (GO:0070271)3.78798071
44purine nucleoside triphosphate biosynthetic process (GO:0009145)3.76484773
45DNA deamination (GO:0045006)3.74658835
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.71437153
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.70303772
48NADH dehydrogenase complex assembly (GO:0010257)3.70303772
49mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.70303772
50nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.70248667
51cornea development in camera-type eye (GO:0061303)3.59527436
52cell proliferation in forebrain (GO:0021846)3.57338108
53positive regulation of T cell apoptotic process (GO:0070234)3.54490978
54establishment of protein localization to membrane (GO:0090150)3.48362987
55ribonucleoside triphosphate biosynthetic process (GO:0009201)3.41211329
56pyrimidine nucleotide catabolic process (GO:0006244)3.40504392
57mitochondrial respiratory chain complex assembly (GO:0033108)3.35386460
58protein targeting (GO:0006605)3.24710562
59GTP biosynthetic process (GO:0006183)3.23679506
60GDP-mannose metabolic process (GO:0019673)3.07268436
61establishment of protein localization to organelle (GO:0072594)3.05651171
62water-soluble vitamin biosynthetic process (GO:0042364)2.97701288
63intracellular protein transmembrane import (GO:0044743)2.97667456
64nucleoside triphosphate biosynthetic process (GO:0009142)2.94399332
65rRNA processing (GO:0006364)2.93902619
66negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.93555466
67outer ear morphogenesis (GO:0042473)2.92669934
68hydrogen ion transmembrane transport (GO:1902600)2.91607789
69rRNA metabolic process (GO:0016072)2.90630688
70base-excision repair, AP site formation (GO:0006285)2.88219253
71pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.83194044
72UTP biosynthetic process (GO:0006228)2.83171349
73cardiovascular system development (GO:0072358)2.82922176
74epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81991487
75protein localization to membrane (GO:0072657)2.77918453
76regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.73446691
77axon ensheathment in central nervous system (GO:0032291)2.72628990
78central nervous system myelination (GO:0022010)2.72628990
79nonmotile primary cilium assembly (GO:0035058)2.72262944
80respiratory chain complex IV assembly (GO:0008535)2.69338090
81cytochrome complex assembly (GO:0017004)2.64942514
82deoxyribonucleotide catabolic process (GO:0009264)2.64380367
83somite development (GO:0061053)2.61652274
84UTP metabolic process (GO:0046051)2.59217177
85proton transport (GO:0015992)2.58948406
86oxidative phosphorylation (GO:0006119)2.58541414
87positive regulation of lymphocyte apoptotic process (GO:0070230)2.52810167
88regulation of cellular respiration (GO:0043457)2.51386483
89hydrogen transport (GO:0006818)2.51046084
90negative regulation of T cell differentiation in thymus (GO:0033085)2.48884055
91endoderm formation (GO:0001706)2.48341259
92interferon-gamma production (GO:0032609)2.47189189
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.47109475
94negative regulation of appetite (GO:0032099)2.46312216
95negative regulation of response to food (GO:0032096)2.46312216
96tongue development (GO:0043586)2.45670329
97nucleoside transmembrane transport (GO:1901642)2.44708165
98ubiquinone biosynthetic process (GO:0006744)2.43944751
99deoxyribose phosphate catabolic process (GO:0046386)2.42204502
100ribosome biogenesis (GO:0042254)2.42137605

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.17690998
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.90299715
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.72808436
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.31768148
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.07498033
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.88195166
7ETS1_20019798_ChIP-Seq_JURKAT_Human2.70373991
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.63283759
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.53632991
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47889287
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.44860042
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.40694844
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36042830
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.34379311
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.20307382
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.15002305
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11541245
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.05641990
19BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01121104
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94621990
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87987737
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.82825164
23XRN2_22483619_ChIP-Seq_HELA_Human1.81974457
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.75934722
25MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72353167
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68433348
27IRF1_19129219_ChIP-ChIP_H3396_Human1.68345220
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66056960
29ZNF274_21170338_ChIP-Seq_K562_Hela1.65091860
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62556581
31KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61079918
32TTF2_22483619_ChIP-Seq_HELA_Human1.60880180
33MYC_18940864_ChIP-ChIP_HL60_Human1.60685550
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60521982
35TP53_20018659_ChIP-ChIP_R1E_Mouse1.55099982
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.54214871
37VDR_22108803_ChIP-Seq_LS180_Human1.53388787
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51537271
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.50943764
40MYC_19079543_ChIP-ChIP_MESCs_Mouse1.46987465
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45626775
42EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40080624
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.39397526
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.39236663
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.37541568
46VDR_23849224_ChIP-Seq_CD4+_Human1.35748600
47CTCF_18555785_ChIP-Seq_MESCs_Mouse1.35103856
48REST_21632747_ChIP-Seq_MESCs_Mouse1.34256451
49RNF2_27304074_Chip-Seq_ESCs_Mouse1.31287559
50EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30164155
51FOXP3_21729870_ChIP-Seq_TREG_Human1.28113905
52BCL6_27268052_Chip-Seq_Bcells_Human1.26925723
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25044132
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25044132
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24781348
56GABP_19822575_ChIP-Seq_HepG2_Human1.23377990
57RNF2_27304074_Chip-Seq_NSC_Mouse1.21335311
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21289375
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.18744081
60TAF2_19829295_ChIP-Seq_ESCs_Human1.17991679
61NANOG_20526341_ChIP-Seq_ESCs_Human1.17720123
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17032013
63SA1_27219007_Chip-Seq_Bcells_Human1.16068308
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14477634
65CTCF_20526341_ChIP-Seq_ESCs_Human1.14180575
66CTCF_27219007_Chip-Seq_Bcells_Human1.12715566
67ERA_21632823_ChIP-Seq_H3396_Human1.11462738
68YY1_22570637_ChIP-Seq_MALME-3M_Human1.11402750
69P68_20966046_ChIP-Seq_HELA_Human1.10856534
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10366783
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.09605181
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08700969
73NCOR_22424771_ChIP-Seq_293T_Human1.07590633
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.07110973
75SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06476914
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.06246516
77P53_21459846_ChIP-Seq_SAOS-2_Human1.05948749
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05397028
79SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.04378946
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.02190024
81FOXP1_21924763_ChIP-Seq_HESCs_Human1.01405850
82CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00853958
83TET1_21451524_ChIP-Seq_MESCs_Mouse1.00790356
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00686556
85E2F1_20622854_ChIP-Seq_HELA_Human1.00246974
86REST_18959480_ChIP-ChIP_MESCs_Mouse0.99057828
87TP53_22573176_ChIP-Seq_HFKS_Human0.98425012
88EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98304944
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98264016
90ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96814558
91MYC_19829295_ChIP-Seq_ESCs_Human0.95490022
92ELK1_19687146_ChIP-ChIP_HELA_Human0.95019573
93MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94537059
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.94163761
95E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92581450
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.92225394
97BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.91239303
98HTT_18923047_ChIP-ChIP_STHdh_Human0.91164213
99CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86818894
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86589728

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.57391314
2MP0006292_abnormal_olfactory_placode4.85502616
3MP0002638_abnormal_pupillary_reflex3.04670493
4MP0003787_abnormal_imprinting2.94733652
5MP0002653_abnormal_ependyma_morphology2.91162331
6MP0008789_abnormal_olfactory_epithelium2.70141724
7MP0003646_muscle_fatigue2.67377012
8MP0002163_abnormal_gland_morphology2.52584013
9MP0002837_dystrophic_cardiac_calcinosis2.41930887
10MP0010030_abnormal_orbit_morphology2.31813020
11MP0003123_paternal_imprinting2.31286307
12MP0005394_taste/olfaction_phenotype2.19498614
13MP0005499_abnormal_olfactory_system2.19498614
14MP0005377_hearing/vestibular/ear_phenot1.99179630
15MP0003878_abnormal_ear_physiology1.99179630
16MP0006276_abnormal_autonomic_nervous1.81950694
17MP0003880_abnormal_central_pattern1.81288151
18MP0000049_abnormal_middle_ear1.79484972
19MP0002234_abnormal_pharynx_morphology1.77706575
20MP0006072_abnormal_retinal_apoptosis1.77313264
21MP0004142_abnormal_muscle_tone1.74577366
22MP0000778_abnormal_nervous_system1.71744640
23MP0004885_abnormal_endolymph1.70449489
24MP0005423_abnormal_somatic_nervous1.68728267
25MP0008877_abnormal_DNA_methylation1.67702521
26MP0002160_abnormal_reproductive_system1.64716740
27MP0005646_abnormal_pituitary_gland1.60137685
28MP0003122_maternal_imprinting1.56915291
29MP0001293_anophthalmia1.55683007
30MP0001485_abnormal_pinna_reflex1.54523519
31MP0003121_genomic_imprinting1.48294546
32MP0002102_abnormal_ear_morphology1.47198020
33MP0003136_yellow_coat_color1.45366295
34MP0001968_abnormal_touch/_nociception1.41824460
35MP0005551_abnormal_eye_electrophysiolog1.38311803
36MP0001986_abnormal_taste_sensitivity1.36920045
37MP0001905_abnormal_dopamine_level1.34566081
38MP0004145_abnormal_muscle_electrophysio1.33285065
39MP0005389_reproductive_system_phenotype1.31226128
40MP0002272_abnormal_nervous_system1.30987332
41MP0001188_hyperpigmentation1.30725010
42MP0004133_heterotaxia1.28412438
43MP0005195_abnormal_posterior_eye1.27110492
44MP0000372_irregular_coat_pigmentation1.26259707
45MP0001529_abnormal_vocalization1.22293512
46MP0000026_abnormal_inner_ear1.21970943
47MP0000631_abnormal_neuroendocrine_gland1.21528891
48MP0002184_abnormal_innervation1.18806041
49MP0005379_endocrine/exocrine_gland_phen1.18762132
50MP0002752_abnormal_somatic_nervous1.18594528
51MP0003879_abnormal_hair_cell1.13322655
52MP0002938_white_spotting1.13285842
53MP0000955_abnormal_spinal_cord1.12413036
54MP0000678_abnormal_parathyroid_gland1.11674299
55MP0003938_abnormal_ear_development1.08876171
56MP0004742_abnormal_vestibular_system1.08409928
57MP0002733_abnormal_thermal_nociception1.08102922
58MP0002736_abnormal_nociception_after1.07270585
59MP0003186_abnormal_redox_activity1.06527691
60MP0009745_abnormal_behavioral_response1.05649611
61MP0001970_abnormal_pain_threshold1.04017078
62MP0002557_abnormal_social/conspecific_i1.03302630
63MP0009053_abnormal_anal_canal1.01176267
64MP0008775_abnormal_heart_ventricle0.99364458
65MP0004147_increased_porphyrin_level0.98177212
66MP0002876_abnormal_thyroid_physiology0.95370075
67MP0003567_abnormal_fetal_cardiomyocyte0.95021714
68MP0002095_abnormal_skin_pigmentation0.94372417
69MP0000566_synostosis0.91232677
70MP0008872_abnormal_physiological_respon0.91072093
71MP0008875_abnormal_xenobiotic_pharmacok0.91045992
72MP0002572_abnormal_emotion/affect_behav0.91045403
73MP0002210_abnormal_sex_determination0.90878081
74MP0002063_abnormal_learning/memory/cond0.88839260
75MP0001963_abnormal_hearing_physiology0.88175722
76MP0001919_abnormal_reproductive_system0.88127168
77MP0001286_abnormal_eye_development0.87191776
78MP0002882_abnormal_neuron_morphology0.85159659
79MP0003011_delayed_dark_adaptation0.83346173
80MP0001486_abnormal_startle_reflex0.82899000
81MP0009250_abnormal_appendicular_skeleto0.82498856
82MP0001440_abnormal_grooming_behavior0.80287456
83MP0003635_abnormal_synaptic_transmissio0.79239685
84MP0002249_abnormal_larynx_morphology0.78724796
85MP0005253_abnormal_eye_physiology0.78107563
86MP0004130_abnormal_muscle_cell0.77911776
87MP0003693_abnormal_embryo_hatching0.77410569
88MP0005671_abnormal_response_to0.76813352
89MP0002822_catalepsy0.75293460
90MP0001727_abnormal_embryo_implantation0.75061550
91MP0001542_abnormal_bone_strength0.73650605
92MP0005391_vision/eye_phenotype0.70593310
93MP0005645_abnormal_hypothalamus_physiol0.70510111
94MP0003942_abnormal_urinary_system0.69511434
95MP0001502_abnormal_circadian_rhythm0.68829730
96MP0002233_abnormal_nose_morphology0.68671841
97MP0005174_abnormal_tail_pigmentation0.68661491
98MP0002735_abnormal_chemical_nociception0.68421839
99MP0002734_abnormal_mechanical_nocicepti0.68113309
100MP0009046_muscle_twitch0.67462303

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.26120218
2Abnormality of cells of the erythroid lineage (HP:0012130)5.77120230
3Macrocytic anemia (HP:0001972)4.66854891
4Acute necrotizing encephalopathy (HP:0006965)4.38012758
5Abnormal number of erythroid precursors (HP:0012131)4.15790682
6Pallor (HP:0000980)3.94117078
7Acute encephalopathy (HP:0006846)3.88196404
8Abnormal mitochondria in muscle tissue (HP:0008316)3.88171654
9Mitochondrial inheritance (HP:0001427)3.83647423
10Hyperglycinemia (HP:0002154)3.53050904
11Increased CSF lactate (HP:0002490)3.45578727
12Progressive macrocephaly (HP:0004481)3.44802149
13Pancreatic fibrosis (HP:0100732)3.42255149
14Absent rod-and cone-mediated responses on ERG (HP:0007688)3.42247213
15Molar tooth sign on MRI (HP:0002419)3.34560514
16Abnormality of midbrain morphology (HP:0002418)3.34560514
17Increased hepatocellular lipid droplets (HP:0006565)3.25699677
18Lipid accumulation in hepatocytes (HP:0006561)3.17586248
19Stenosis of the external auditory canal (HP:0000402)3.02698415
20Renal Fanconi syndrome (HP:0001994)2.99888664
21Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96698000
22Absent thumb (HP:0009777)2.92915823
23True hermaphroditism (HP:0010459)2.92850182
24Abnormal rod and cone electroretinograms (HP:0008323)2.89113265
25Hepatocellular necrosis (HP:0001404)2.87159773
263-Methylglutaconic aciduria (HP:0003535)2.86408006
27Pancreatic cysts (HP:0001737)2.82122417
28Congenital stationary night blindness (HP:0007642)2.79412736
29Septo-optic dysplasia (HP:0100842)2.72803700
30Cerebral edema (HP:0002181)2.71693649
31Hepatic necrosis (HP:0002605)2.58006947
32Depressed nasal ridge (HP:0000457)2.52068029
33Nephronophthisis (HP:0000090)2.47521435
34Sclerocornea (HP:0000647)2.47166909
35Increased intramyocellular lipid droplets (HP:0012240)2.46191033
36Microretrognathia (HP:0000308)2.45445235
37Medial flaring of the eyebrow (HP:0010747)2.45145344
38Abnormality of alanine metabolism (HP:0010916)2.38082904
39Hyperalaninemia (HP:0003348)2.38082904
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38082904
41Agitation (HP:0000713)2.36455963
42Rib fusion (HP:0000902)2.35291140
43Optic disc pallor (HP:0000543)2.33368118
44Respiratory difficulties (HP:0002880)2.32580615
45Pendular nystagmus (HP:0012043)2.32289938
46Abnormal hemoglobin (HP:0011902)2.27926151
47Abnormality of renal resorption (HP:0011038)2.27719223
48Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27095159
49Absent/shortened dynein arms (HP:0200106)2.21562964
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.21562964
51Anencephaly (HP:0002323)2.19051901
52Global brain atrophy (HP:0002283)2.17088984
53Chronic hepatic failure (HP:0100626)2.16569603
54Increased muscle lipid content (HP:0009058)2.14794297
55Myokymia (HP:0002411)2.13676704
56Increased serum lactate (HP:0002151)2.13437784
57Type II lissencephaly (HP:0007260)2.12165693
58Aplasia/Hypoplasia of the spleen (HP:0010451)2.11643383
59Asplenia (HP:0001746)2.09205789
60Gait imbalance (HP:0002141)2.09074829
61Lactic acidosis (HP:0003128)2.07227890
62Congenital primary aphakia (HP:0007707)2.05113303
63Dyskinesia (HP:0100660)2.05063789
64Methylmalonic acidemia (HP:0002912)2.03790336
65Abnormal respiratory epithelium morphology (HP:0012253)2.02642451
66Abnormal respiratory motile cilium morphology (HP:0005938)2.02642451
67Cystic liver disease (HP:0006706)2.01814804
68Nephrogenic diabetes insipidus (HP:0009806)2.01461083
69Hyperthyroidism (HP:0000836)1.97066180
70Exertional dyspnea (HP:0002875)1.96905106
71Maternal diabetes (HP:0009800)1.96288577
72Abnormality of the renal medulla (HP:0100957)1.95191526
73Decreased central vision (HP:0007663)1.94414092
74Partial duplication of the phalanx of hand (HP:0009999)1.93798799
75Hypoplasia of the radius (HP:0002984)1.91499513
76Adrenal hypoplasia (HP:0000835)1.91271191
77Patent foramen ovale (HP:0001655)1.90300975
78Restlessness (HP:0000711)1.87415871
79Leukodystrophy (HP:0002415)1.87374011
80Abolished electroretinogram (ERG) (HP:0000550)1.83199665
81Hypoplasia of the ulna (HP:0003022)1.82148384
82Colon cancer (HP:0003003)1.82030849
83Abnormality of DNA repair (HP:0003254)1.81288637
84Anophthalmia (HP:0000528)1.80702382
85Postaxial foot polydactyly (HP:0001830)1.79821221
86Lethargy (HP:0001254)1.79493965
87Dysphonia (HP:0001618)1.79300812
88Abnormal ciliary motility (HP:0012262)1.77007782
89Respiratory failure (HP:0002878)1.76125836
90Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75135211
91Abnormality of glycine metabolism (HP:0010895)1.73256096
92Abnormality of serine family amino acid metabolism (HP:0010894)1.73256096
93Hyperphosphaturia (HP:0003109)1.73145252
94Abnormality of the renal collecting system (HP:0004742)1.72329825
95Male pseudohermaphroditism (HP:0000037)1.72150918
96Muscle fiber atrophy (HP:0100295)1.71963787
97Glycosuria (HP:0003076)1.71954696
98Abnormality of urine glucose concentration (HP:0011016)1.71954696
99Type 2 muscle fiber atrophy (HP:0003554)1.71485288
100Abnormal respiratory motile cilium physiology (HP:0012261)1.71287493

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME23.51104249
2STK163.28109430
3PDK23.18884798
4BCKDK3.00137021
5WNK42.97099408
6TLK12.62823470
7DYRK22.50488734
8VRK22.50269374
9CDK192.44192042
10PASK2.43215294
11ADRBK22.40828406
12MAP4K22.27804558
13TXK2.11431645
14GRK12.09631954
15PIK3CA2.03176170
16ZAK1.91367784
17MAP3K41.49354319
18NUAK11.48559604
19MAP2K71.41096272
20STK391.39523585
21PINK11.35655602
22LRRK21.34806460
23TIE11.29866081
24CDC71.26505458
25NEK21.25995093
26AURKA1.25326211
27TAF11.21844670
28CASK1.21090842
29ABL21.18964198
30CAMKK21.16927063
31EPHB21.14794559
32TYRO31.13916147
33CAMKK11.11954921
34PRKCG1.07053773
35MAP3K111.05471233
36GRK51.05045258
37VRK11.04919139
38WNK31.01108929
39BRAF1.00487090
40FRK1.00001429
41NTRK20.93077891
42EPHA40.92698427
43ADRBK10.87615268
44STK110.87544126
45RPS6KA60.87059792
46CAMK10.82467330
47BMPR1B0.81909602
48PLK40.81663307
49DAPK30.81596189
50DYRK1B0.81587793
51NEK10.81326288
52PRKCQ0.73318783
53PRKD30.73273502
54BRSK10.72472706
55DYRK30.72190555
56TEC0.70220684
57NTRK30.69360383
58LIMK10.69211990
59INSRR0.66134297
60ITK0.66031875
61MAP2K20.65683926
62RPS6KC10.65339446
63RPS6KL10.65339446
64CSNK2A20.64968116
65SGK4940.64412270
66SGK2230.64412270
67OXSR10.63574894
68PRKCH0.63466739
69CSNK1G20.62699145
70CSNK1G30.61321918
71AURKB0.61235576
72PRKACA0.61060620
73RPS6KA50.59925762
74MAP3K90.59173266
75PRKCD0.57769082
76KDR0.57285249
77PLK10.55826229
78MAPKAPK50.53546801
79BTK0.53109411
80PRKCI0.51104572
81ATR0.50283300
82CSNK2A10.49959774
83CHEK20.49430757
84TGFBR10.48293792
85PRKCA0.47625748
86MAP2K40.43722148
87MAPK150.43526767
88TESK20.43282732
89CSNK1E0.42257765
90MAP2K60.41879431
91OBSCN0.41069796
92MAPK130.40805472
93CSNK1A1L0.39032332
94IKBKB0.39022309
95PAK30.38948414
96LCK0.38324915
97MINK10.37532019
98MUSK0.37006921
99CAMK1D0.36119605
100RPS6KB20.35834904

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.21248645
2Oxidative phosphorylation_Homo sapiens_hsa001904.57688968
3Parkinsons disease_Homo sapiens_hsa050123.86094269
4Huntingtons disease_Homo sapiens_hsa050162.72342374
5Alzheimers disease_Homo sapiens_hsa050102.66911322
6Cardiac muscle contraction_Homo sapiens_hsa042602.59650515
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.57024858
8Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.49440986
9RNA polymerase_Homo sapiens_hsa030201.98112871
10Linoleic acid metabolism_Homo sapiens_hsa005911.84057827
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.73032392
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62200250
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59413364
14RNA degradation_Homo sapiens_hsa030181.58543678
15Phototransduction_Homo sapiens_hsa047441.52367760
16Sulfur relay system_Homo sapiens_hsa041221.48721956
17Homologous recombination_Homo sapiens_hsa034401.47574466
18Fanconi anemia pathway_Homo sapiens_hsa034601.29498925
19Pyrimidine metabolism_Homo sapiens_hsa002401.27320918
20Proteasome_Homo sapiens_hsa030501.25381631
21Basal cell carcinoma_Homo sapiens_hsa052171.22449671
22Hedgehog signaling pathway_Homo sapiens_hsa043401.21640387
23Protein export_Homo sapiens_hsa030601.16090153
24DNA replication_Homo sapiens_hsa030301.12246772
25Mismatch repair_Homo sapiens_hsa034301.10436338
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09534596
27Regulation of autophagy_Homo sapiens_hsa041401.08348875
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02823155
29Basal transcription factors_Homo sapiens_hsa030221.02127296
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00939287
31Sulfur metabolism_Homo sapiens_hsa009201.00505564
32One carbon pool by folate_Homo sapiens_hsa006700.98893920
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97532618
34Nicotine addiction_Homo sapiens_hsa050330.93398369
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91398761
36Peroxisome_Homo sapiens_hsa041460.89789510
37Nucleotide excision repair_Homo sapiens_hsa034200.88235324
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87040970
39Nitrogen metabolism_Homo sapiens_hsa009100.86033906
40Olfactory transduction_Homo sapiens_hsa047400.83624074
41Arachidonic acid metabolism_Homo sapiens_hsa005900.83621838
42Base excision repair_Homo sapiens_hsa034100.82603378
43Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.82162552
44Propanoate metabolism_Homo sapiens_hsa006400.79714484
45Tryptophan metabolism_Homo sapiens_hsa003800.78821354
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76507032
47Purine metabolism_Homo sapiens_hsa002300.75111126
48Metabolic pathways_Homo sapiens_hsa011000.74530024
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74244361
50Morphine addiction_Homo sapiens_hsa050320.73415286
51Ether lipid metabolism_Homo sapiens_hsa005650.72587692
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71825016
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.71655744
54Primary immunodeficiency_Homo sapiens_hsa053400.68885538
55Fat digestion and absorption_Homo sapiens_hsa049750.66651436
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.66447586
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66272168
58Butanoate metabolism_Homo sapiens_hsa006500.64624896
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62879970
60Phenylalanine metabolism_Homo sapiens_hsa003600.60646627
61Tyrosine metabolism_Homo sapiens_hsa003500.56727987
62Spliceosome_Homo sapiens_hsa030400.55753642
63Asthma_Homo sapiens_hsa053100.55444104
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.54523261
65Caffeine metabolism_Homo sapiens_hsa002320.52947536
66Pyruvate metabolism_Homo sapiens_hsa006200.52251040
67Selenocompound metabolism_Homo sapiens_hsa004500.51211688
68Retinol metabolism_Homo sapiens_hsa008300.50881914
69Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50594908
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49018426
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.46709947
72Chemical carcinogenesis_Homo sapiens_hsa052040.43795174
73Collecting duct acid secretion_Homo sapiens_hsa049660.42309436
74Arginine and proline metabolism_Homo sapiens_hsa003300.40568926
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38602427
76Insulin secretion_Homo sapiens_hsa049110.38454632
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38343731
78RNA transport_Homo sapiens_hsa030130.38317445
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37572630
80Taste transduction_Homo sapiens_hsa047420.35660454
81Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34851777
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34127990
83Vitamin B6 metabolism_Homo sapiens_hsa007500.33722154
84Serotonergic synapse_Homo sapiens_hsa047260.33683136
85Fatty acid degradation_Homo sapiens_hsa000710.33162510
86GABAergic synapse_Homo sapiens_hsa047270.31779143
87beta-Alanine metabolism_Homo sapiens_hsa004100.31586596
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31215130
89Autoimmune thyroid disease_Homo sapiens_hsa053200.30829537
90Folate biosynthesis_Homo sapiens_hsa007900.29280364
91Allograft rejection_Homo sapiens_hsa053300.29261608
92Glutamatergic synapse_Homo sapiens_hsa047240.28648617
93Ovarian steroidogenesis_Homo sapiens_hsa049130.28020137
94Axon guidance_Homo sapiens_hsa043600.27889019
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.26997860
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25850247
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.25493119
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24882244
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22456633
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.22037797

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