RPL38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* establishment of protein localization to endoplasmic reticulum (GO:0072599)9.82061750
2* protein localization to endoplasmic reticulum (GO:0070972)9.59170594
3* cellular protein complex disassembly (GO:0043624)9.57685120
4* viral life cycle (GO:0019058)9.49859345
5* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)9.28698501
6* translational initiation (GO:0006413)8.57225967
7maturation of SSU-rRNA (GO:0030490)8.51435385
8* protein complex disassembly (GO:0043241)8.22447570
9* macromolecular complex disassembly (GO:0032984)7.67127065
10ribosomal large subunit biogenesis (GO:0042273)7.43692082
11* protein targeting to membrane (GO:0006612)6.89870476
12* nuclear-transcribed mRNA catabolic process (GO:0000956)6.33166018
13* translation (GO:0006412)6.16307094
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.12875370
15* mRNA catabolic process (GO:0006402)5.98364962
16ATP synthesis coupled proton transport (GO:0015986)5.87630842
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.87630842
18ribonucleoprotein complex biogenesis (GO:0022613)5.60147740
19* RNA catabolic process (GO:0006401)5.43311801
20* establishment of protein localization to membrane (GO:0090150)4.72103371
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.55033972
22cellular component biogenesis (GO:0044085)4.37881648
23* protein targeting (GO:0006605)4.34553026
24rRNA processing (GO:0006364)4.23177653
25respiratory electron transport chain (GO:0022904)4.15282344
26* establishment of protein localization to organelle (GO:0072594)4.11505346
27GTP biosynthetic process (GO:0006183)4.08893356
28electron transport chain (GO:0022900)4.06207210
29rRNA metabolic process (GO:0016072)4.05306579
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.00678360
31UTP biosynthetic process (GO:0006228)3.90228456
32DNA deamination (GO:0045006)3.82986287
33establishment of integrated proviral latency (GO:0075713)3.74281232
34* protein localization to membrane (GO:0072657)3.67363619
35ncRNA 3-end processing (GO:0043628)3.64056659
36formation of translation preinitiation complex (GO:0001731)3.43792747
37spliceosomal complex assembly (GO:0000245)3.42419776
38pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41312217
39protein neddylation (GO:0045116)3.39373746
40UTP metabolic process (GO:0046051)3.36067332
41inner mitochondrial membrane organization (GO:0007007)3.33440315
42termination of RNA polymerase III transcription (GO:0006386)3.28826694
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.28826694
44spliceosomal snRNP assembly (GO:0000387)3.27443742
45protein localization to mitochondrion (GO:0070585)3.22343181
46hydrogen ion transmembrane transport (GO:1902600)3.20043780
47establishment of viral latency (GO:0019043)3.15705409
48* cellular component disassembly (GO:0022411)3.08051585
49CTP biosynthetic process (GO:0006241)3.05165811
50CTP metabolic process (GO:0046036)3.05165811
51nucleoside triphosphate biosynthetic process (GO:0009142)3.04286877
52chromatin remodeling at centromere (GO:0031055)3.00814028
53proteasome assembly (GO:0043248)3.00505703
54mitochondrial transport (GO:0006839)2.98628675
55pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98393387
56guanosine-containing compound biosynthetic process (GO:1901070)2.97607452
57purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.97484556
58* protein localization to organelle (GO:0033365)2.97355278
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96662630
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.93205292
61intracellular protein transmembrane import (GO:0044743)2.90665333
62purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86858492
63pyrimidine nucleotide catabolic process (GO:0006244)2.85264331
64DNA replication checkpoint (GO:0000076)2.84378443
65behavioral response to nicotine (GO:0035095)2.81007049
66ribonucleoside triphosphate biosynthetic process (GO:0009201)2.75475445
67pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.74026081
68CENP-A containing nucleosome assembly (GO:0034080)2.73290434
69protein-cofactor linkage (GO:0018065)2.72959890
70oxidative phosphorylation (GO:0006119)2.72817177
71ribosome biogenesis (GO:0042254)2.71461903
72chaperone-mediated protein transport (GO:0072321)2.70927149
73purine nucleoside monophosphate biosynthetic process (GO:0009127)2.70457350
74purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.70457350
75negative regulation of RNA splicing (GO:0033119)2.66085911
76ATP biosynthetic process (GO:0006754)2.65653470
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.65594766
78kinetochore assembly (GO:0051382)2.64690305
79pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.63512236
80proton transport (GO:0015992)2.63279195
81DNA damage response, detection of DNA damage (GO:0042769)2.63177991
82* gene expression (GO:0010467)2.61204406
83heterochromatin organization (GO:0070828)2.61014364
84ncRNA processing (GO:0034470)2.59274037
85regulation of protein heterodimerization activity (GO:0043497)2.57934361
86hydrogen transport (GO:0006818)2.57180119
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.57138103
88protein complex biogenesis (GO:0070271)2.55196866
89pseudouridine synthesis (GO:0001522)2.54648373
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.54163691
91establishment of protein localization to mitochondrion (GO:0072655)2.51998058
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51428025
93tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51428025
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.50570952
95mitochondrial respiratory chain complex I assembly (GO:0032981)2.50570952
96NADH dehydrogenase complex assembly (GO:0010257)2.50570952
97kinetochore organization (GO:0051383)2.49356969
98protein targeting to mitochondrion (GO:0006626)2.48531891
99histone mRNA metabolic process (GO:0008334)2.45188615
1007-methylguanosine mRNA capping (GO:0006370)2.43891875
101negative regulation of ligase activity (GO:0051352)2.43569579
102negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.43569579
103regulation of mitochondrial translation (GO:0070129)2.42794410
104DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.42322865
105telomere maintenance via semi-conservative replication (GO:0032201)2.42321030
106transcription elongation from RNA polymerase I promoter (GO:0006362)2.42225377
1077-methylguanosine RNA capping (GO:0009452)2.41815214
108RNA capping (GO:0036260)2.41815214
109mitochondrial respiratory chain complex assembly (GO:0033108)2.41777619
110termination of RNA polymerase I transcription (GO:0006363)2.41684852
111DNA strand elongation involved in DNA replication (GO:0006271)2.38619457
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.36734530
113intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.36284690
114signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.36284690
115ncRNA metabolic process (GO:0034660)2.35449782
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.34917307
117signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34917307
118* viral transcription (GO:0019083)12.8470348
119ribosomal small subunit biogenesis (GO:0042274)12.7706210
120* translational termination (GO:0006415)12.2816062
121ribosomal small subunit assembly (GO:0000028)10.7541337
122* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)10.4024647
123* cotranslational protein targeting to membrane (GO:0006613)10.2842327
124* protein targeting to ER (GO:0045047)10.2559832
125* translational elongation (GO:0006414)10.1771545

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat7.31303892
2* MYC_18555785_ChIP-Seq_MESCs_Mouse5.30986061
3* MYC_19079543_ChIP-ChIP_MESCs_Mouse4.04008077
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.01618399
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.91001570
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.80256122
7E2F7_22180533_ChIP-Seq_HELA_Human3.59138347
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.54479983
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.42620840
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41625250
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.21749740
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.14324443
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.10469719
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04898569
15* XRN2_22483619_ChIP-Seq_HELA_Human3.01714631
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85167061
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.79514531
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.74277656
19* TTF2_22483619_ChIP-Seq_HELA_Human2.64268754
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58394310
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.39558287
22* VDR_23849224_ChIP-Seq_CD4+_Human2.34619820
23DCP1A_22483619_ChIP-Seq_HELA_Human2.28846474
24* ELK1_19687146_ChIP-ChIP_HELA_Human2.26001694
25TP63_17297297_ChIP-ChIP_HaCaT_Human2.25435446
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.10709267
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.08806064
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07129963
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97109922
30* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.96703951
31ELK1_22589737_ChIP-Seq_MCF10A_Human1.96210805
32NELFA_20434984_ChIP-Seq_ESCs_Mouse1.95888851
33* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.93614905
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93141905
35ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.89862668
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.89629079
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89537252
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.84246137
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.77947599
40EZH2_22144423_ChIP-Seq_EOC_Human1.67547712
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.63753140
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63721283
43YY1_21170310_ChIP-Seq_MESCs_Mouse1.61331744
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.59069758
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.59069758
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.59069758
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.58443434
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.55372044
49STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55058511
50* MYC_18940864_ChIP-ChIP_HL60_Human1.54515444
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53851960
52GABP_19822575_ChIP-Seq_HepG2_Human1.44047887
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.38754767
54SOX2_18555785_ChIP-Seq_MESCs_Mouse1.31680715
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.30328240
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29757779
57* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26927815
58OCT4_18692474_ChIP-Seq_MEFs_Mouse1.25637427
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.24578619
60NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22517793
61CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.21307217
62* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20138167
63* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.20065720
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19733963
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.19544439
66IRF1_19129219_ChIP-ChIP_H3396_Human1.19537579
67TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19424965
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.17656400
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17416160
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.16029885
71SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15616019
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.15566773
73CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13107764
74* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11570444
75SOX2_18692474_ChIP-Seq_MEFs_Mouse1.10487481
76* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10228085
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10061084
78TET1_21451524_ChIP-Seq_MESCs_Mouse1.09843619
79ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09713799
80POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09130075
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.08978741
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.08824651
83FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08594354
84VDR_21846776_ChIP-Seq_THP-1_Human1.06643883
85TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06089301
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05436438
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05405299
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.00883139
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.98876010
90* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97239614
91CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96927868
92CBX2_27304074_Chip-Seq_ESCs_Mouse0.96876201
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96713365
94PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96088802
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.95525736
96TP53_20018659_ChIP-ChIP_R1E_Mouse0.92165323
97SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91172358
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89887500
99CTCF_26484167_Chip-Seq_Bcells_Mouse0.89004610
100CIITA_25753668_ChIP-Seq_RAJI_Human0.87652698
101STAT1_20625510_ChIP-Seq_HELA_Human0.87547249
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87188389
103TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.86648588
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86445010
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85787120
106NANOG_18692474_ChIP-Seq_MEFs_Mouse0.83491048
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.82495223
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.82036407
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81776416
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80641367
111ZNF263_19887448_ChIP-Seq_K562_Human0.80477523
112DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80320875
113ELF5_23300383_ChIP-Seq_T47D_Human0.79343304
114YY1_22570637_ChIP-Seq_MALME-3M_Human0.79220267
115SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78880211
116* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78476110
117SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.78255362
118P68_20966046_ChIP-Seq_HELA_Human0.78009289
119E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.77863018
120KDM5A_27292631_Chip-Seq_BREAST_Human0.77324232
121* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.77262766
122SA1_27219007_Chip-Seq_Bcells_Human0.76648353
123* SOX17_20123909_ChIP-Seq_XEN_Mouse0.76134263
124ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76001993

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation9.69179145
2MP0003136_yellow_coat_color3.42252065
3MP0003693_abnormal_embryo_hatching3.15055785
4MP0004957_abnormal_blastocyst_morpholog2.82329239
5MP0004381_abnormal_hair_follicle2.52905558
6MP0000566_synostosis2.38035792
7MP0002653_abnormal_ependyma_morphology2.19563783
8MP0008932_abnormal_embryonic_tissue2.04694295
9MP0002938_white_spotting2.03007050
10MP0001293_anophthalmia1.97172117
11MP0005409_darkened_coat_color1.88921846
12MP0002638_abnormal_pupillary_reflex1.80573132
13MP0003077_abnormal_cell_cycle1.79727135
14MP0005174_abnormal_tail_pigmentation1.78896699
15MP0002277_abnormal_respiratory_mucosa1.67763760
16MP0000372_irregular_coat_pigmentation1.65023183
17MP0000049_abnormal_middle_ear1.64806837
18MP0004142_abnormal_muscle_tone1.61164581
19MP0003941_abnormal_skin_development1.60886508
20MP0003786_premature_aging1.59657428
21MP0005408_hypopigmentation1.53843465
22MP0010094_abnormal_chromosome_stability1.53701666
23MP0002160_abnormal_reproductive_system1.53133608
24MP0002163_abnormal_gland_morphology1.52883950
25MP0003315_abnormal_perineum_morphology1.52094276
26MP0008057_abnormal_DNA_replication1.48864057
27MP0008995_early_reproductive_senescence1.48205858
28MP0002102_abnormal_ear_morphology1.48124361
29MP0003718_maternal_effect1.46186058
30MP0010030_abnormal_orbit_morphology1.42415419
31MP0009333_abnormal_splenocyte_physiolog1.42362053
32MP0002751_abnormal_autonomic_nervous1.40117039
33MP0003111_abnormal_nucleus_morphology1.37248398
34MP0004133_heterotaxia1.36904943
35MP0002095_abnormal_skin_pigmentation1.34727332
36MP0003938_abnormal_ear_development1.34423578
37MP0000631_abnormal_neuroendocrine_gland1.34100907
38MP0001188_hyperpigmentation1.33832519
39MP0002282_abnormal_trachea_morphology1.33632852
40MP0001727_abnormal_embryo_implantation1.33572042
41MP0002796_impaired_skin_barrier1.33003510
42MP0006292_abnormal_olfactory_placode1.30291760
43MP0001529_abnormal_vocalization1.29215529
44MP0000490_abnormal_crypts_of1.28559163
45MP0000762_abnormal_tongue_morphology1.26109138
46MP0002249_abnormal_larynx_morphology1.26009482
47MP0006072_abnormal_retinal_apoptosis1.22805360
48MP0008789_abnormal_olfactory_epithelium1.21571907
49MP0001905_abnormal_dopamine_level1.21184943
50MP0005084_abnormal_gallbladder_morpholo1.20533497
51MP0003123_paternal_imprinting1.18867246
52MP0000750_abnormal_muscle_regeneration1.18626372
53MP0006036_abnormal_mitochondrial_physio1.14785868
54MP0001879_abnormal_lymphatic_vessel1.12567620
55MP0003121_genomic_imprinting1.12264325
56MP0005389_reproductive_system_phenotype1.12152930
57MP0002234_abnormal_pharynx_morphology1.11822724
58MP0005501_abnormal_skin_physiology1.11140366
59MP0002210_abnormal_sex_determination1.07605430
60MP0001485_abnormal_pinna_reflex1.07439124
61MP0002132_abnormal_respiratory_system1.05383248
62MP0003880_abnormal_central_pattern1.03411406
63MP0009053_abnormal_anal_canal1.02960013
64MP0003787_abnormal_imprinting0.99190217
65MP0003122_maternal_imprinting0.98808315
66MP0003942_abnormal_urinary_system0.96534080
67MP0000613_abnormal_salivary_gland0.95125333
68MP0003890_abnormal_embryonic-extraembry0.94597531
69MP0004742_abnormal_vestibular_system0.94582842
70MP0003763_abnormal_thymus_physiology0.94256713
71MP0002233_abnormal_nose_morphology0.94177587
72MP0004145_abnormal_muscle_electrophysio0.91239268
73MP0005377_hearing/vestibular/ear_phenot0.89940668
74MP0003878_abnormal_ear_physiology0.89940668
75MP0000703_abnormal_thymus_morphology0.89493939
76MP0000778_abnormal_nervous_system0.89322917
77MP0002098_abnormal_vibrissa_morphology0.88889647
78MP0003567_abnormal_fetal_cardiomyocyte0.88779438
79MP0008058_abnormal_DNA_repair0.88105179
80MP0005075_abnormal_melanosome_morpholog0.87961433
81MP0000350_abnormal_cell_proliferation0.87062486
82MP0001286_abnormal_eye_development0.84989299
83MP0001730_embryonic_growth_arrest0.84928333
84MP0005083_abnormal_biliary_tract0.84505921
85MP0003011_delayed_dark_adaptation0.84338183
86MP0003646_muscle_fatigue0.84099678
87MP0000026_abnormal_inner_ear0.83076111
88MP0009250_abnormal_appendicular_skeleto0.82444874
89MP0002752_abnormal_somatic_nervous0.80680322
90MP0003755_abnormal_palate_morphology0.80580825
91MP0005195_abnormal_posterior_eye0.79891833
92MP0001145_abnormal_male_reproductive0.79210900
93MP0000537_abnormal_urethra_morphology0.79145590
94MP0001346_abnormal_lacrimal_gland0.79134639
95MP0004272_abnormal_basement_membrane0.78482127
96MP0002396_abnormal_hematopoietic_system0.78352441
97MP0008007_abnormal_cellular_replicative0.77902612
98MP0005379_endocrine/exocrine_gland_phen0.76631662
99MP0002092_abnormal_eye_morphology0.75774690
100MP0003937_abnormal_limbs/digits/tail_de0.75690464
101MP0002932_abnormal_joint_morphology0.75287884
102MP0002184_abnormal_innervation0.74973460
103MP0003638_abnormal_response/metabolism_0.73986068
104MP0006035_abnormal_mitochondrial_morpho0.73682978
105MP0005394_taste/olfaction_phenotype0.73626171
106MP0005499_abnormal_olfactory_system0.73626171
107MP0001348_abnormal_lacrimal_gland0.73620310
108MP0002722_abnormal_immune_system0.73532360
109MP0002177_abnormal_outer_ear0.73150083
110MP0000955_abnormal_spinal_cord0.72947441
111MP0002837_dystrophic_cardiac_calcinosis0.72856406
112MP0005646_abnormal_pituitary_gland0.72821557
113MP0005391_vision/eye_phenotype0.72125144
114MP0001853_heart_inflammation0.70746406
115MP0000653_abnormal_sex_gland0.70603971
116MP0003861_abnormal_nervous_system0.70468623
117MP0006276_abnormal_autonomic_nervous0.70264894
118MP0002822_catalepsy0.69829571
119MP0004808_abnormal_hematopoietic_stem0.69073435
120MP0003283_abnormal_digestive_organ0.68917335
121MP0002085_abnormal_embryonic_tissue0.68716733
122MP0003186_abnormal_redox_activity0.68660905
123MP0002736_abnormal_nociception_after0.67314037
124MP0001697_abnormal_embryo_size0.67026476
125MP0005423_abnormal_somatic_nervous0.66663240
126MP0002405_respiratory_system_inflammati0.65136720
127MP0001968_abnormal_touch/_nociception0.64431605
128MP0002116_abnormal_craniofacial_bone0.64406410
129MP0001919_abnormal_reproductive_system0.64200442
130MP0001873_stomach_inflammation0.63714843
131MP0003806_abnormal_nucleotide_metabolis0.63435649
132MP0002080_prenatal_lethality0.63243556
133MP0000858_altered_metastatic_potential0.62725395
134MP0001440_abnormal_grooming_behavior0.62437497
135MP0002697_abnormal_eye_size0.62302014
136MP0003119_abnormal_digestive_system0.62042579
137MP0003936_abnormal_reproductive_system0.61934971
138MP0002557_abnormal_social/conspecific_i0.61863516
139* MP0000313_abnormal_cell_death0.61475688
140MP0002148_abnormal_hypersensitivity_rea0.61152069
141MP0001800_abnormal_humoral_immune0.61065760
142MP0002398_abnormal_bone_marrow0.60346440
143MP0002111_abnormal_tail_morphology0.59299184
144MP0000470_abnormal_stomach_morphology0.59212148
145MP0005367_renal/urinary_system_phenotyp0.58865125
146MP0000516_abnormal_urinary_system0.58865125
147MP0002019_abnormal_tumor_incidence0.58784310
148MP0001340_abnormal_eyelid_morphology0.58075939
149MP0010771_integument_phenotype0.57215920

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)9.54699191
2Reticulocytopenia (HP:0001896)9.30217484
3Macrocytic anemia (HP:0001972)7.67976540
4Pallor (HP:0000980)6.79280292
5Acute necrotizing encephalopathy (HP:0006965)4.77006409
6Increased hepatocellular lipid droplets (HP:0006565)4.57903689
7Mitochondrial inheritance (HP:0001427)4.30311629
8Abnormal hemoglobin (HP:0011902)4.22814785
9Abnormal mitochondria in muscle tissue (HP:0008316)4.04324487
10Progressive macrocephaly (HP:0004481)3.96988811
11Lipid accumulation in hepatocytes (HP:0006561)3.87417339
12Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.72690858
13Aplasia/Hypoplasia of the sacrum (HP:0008517)3.67069310
14Renal Fanconi syndrome (HP:0001994)3.57551233
15Acute encephalopathy (HP:0006846)3.52934321
16Congenital, generalized hypertrichosis (HP:0004540)3.51759663
17Increased CSF lactate (HP:0002490)3.43363587
18Exertional dyspnea (HP:0002875)3.43353339
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.29692709
20Hepatocellular necrosis (HP:0001404)3.21106602
21Stenosis of the external auditory canal (HP:0000402)3.19659536
22Abnormality of reticulocytes (HP:0004312)3.12444623
23Abnormality of secondary sexual hair (HP:0009888)3.10299586
24Abnormality of the axillary hair (HP:0100134)3.10299586
25Depressed nasal ridge (HP:0000457)3.05387076
26Decreased activity of mitochondrial respiratory chain (HP:0008972)2.99517908
27Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.99517908
283-Methylglutaconic aciduria (HP:0003535)2.96119394
29Increased intramyocellular lipid droplets (HP:0012240)2.94243028
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.93699906
31Respiratory difficulties (HP:0002880)2.80839665
32Migraine (HP:0002076)2.79497230
33Parakeratosis (HP:0001036)2.70078569
34Septo-optic dysplasia (HP:0100842)2.65152328
35Multiple enchondromatosis (HP:0005701)2.62357582
36Absent thumb (HP:0009777)2.60211363
37Exercise intolerance (HP:0003546)2.59821413
3811 pairs of ribs (HP:0000878)2.59457582
39Optic disc pallor (HP:0000543)2.58686188
40Rib fusion (HP:0000902)2.55052509
41Woolly hair (HP:0002224)2.53731602
42Concave nail (HP:0001598)2.52230490
43Trismus (HP:0000211)2.51962461
44Thick lower lip vermilion (HP:0000179)2.51761104
45Hepatic necrosis (HP:0002605)2.44935310
46Partial duplication of the phalanx of hand (HP:0009999)2.42205874
47Asplenia (HP:0001746)2.41975822
48Partial duplication of thumb phalanx (HP:0009944)2.40298414
49Colon cancer (HP:0003003)2.39475737
50Respiratory failure (HP:0002878)2.32312551
51Myokymia (HP:0002411)2.31263143
52Hypoplasia of the radius (HP:0002984)2.30576178
53Glossoptosis (HP:0000162)2.29567154
54Maternal diabetes (HP:0009800)2.27698451
55Increased muscle lipid content (HP:0009058)2.27132283
56Triphalangeal thumb (HP:0001199)2.21456522
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.20852331
58Cerebral edema (HP:0002181)2.20704888
59Leukodystrophy (HP:0002415)2.18895878
60Birth length less than 3rd percentile (HP:0003561)2.16649453
61Aplastic anemia (HP:0001915)2.16490584
62Abnormality of the parietal bone (HP:0002696)2.13560160
63Congenital ichthyosiform erythroderma (HP:0007431)2.13090381
64Thrombocytosis (HP:0001894)2.10628046
65Abdominal situs inversus (HP:0003363)2.10562220
66Abnormality of abdominal situs (HP:0011620)2.10562220
67Increased serum lactate (HP:0002151)2.02912225
68Hyperglycinemia (HP:0002154)2.02620855
69Sparse lateral eyebrow (HP:0005338)2.00120970
70Abnormality of cells of the erythroid lineage (HP:0012130)11.0192340
71Abnormality of placental membranes (HP:0011409)1.99794627
72Amniotic constriction ring (HP:0009775)1.99794627
73Esophageal atresia (HP:0002032)1.99753364
74Abnormality of urine glucose concentration (HP:0011016)1.99408053
75Glycosuria (HP:0003076)1.99408053
76Abnormality of renal resorption (HP:0011038)1.97911223
77Aplasia cutis congenita (HP:0001057)1.95899002
78Anophthalmia (HP:0000528)1.94165448
79Hyperphosphaturia (HP:0003109)1.86455903
80Breast hypoplasia (HP:0003187)1.86255109
81Abnormality of midbrain morphology (HP:0002418)1.85918714
82Molar tooth sign on MRI (HP:0002419)1.85918714
83Carpal bone hypoplasia (HP:0001498)1.84253200
84Fragile nails (HP:0001808)1.82035431
85Absent septum pellucidum (HP:0001331)1.81282961
86Nasolacrimal duct obstruction (HP:0000579)1.78977408
87Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78335430
88Lethargy (HP:0001254)1.77538756
89Broad distal phalanx of finger (HP:0009836)1.75337443
90Abnormal number of incisors (HP:0011064)1.75010733
91Lactic acidosis (HP:0003128)1.74713700
92Missing ribs (HP:0000921)1.74581925
93Sensory axonal neuropathy (HP:0003390)1.73552859
94Hypoplasia of the pons (HP:0012110)1.73277428
95Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72868962
96Oral leukoplakia (HP:0002745)1.70791062
97Absent radius (HP:0003974)1.70619544
98Pancreatic fibrosis (HP:0100732)1.68009684
99Atresia of the external auditory canal (HP:0000413)1.67258154
100Absent hand (HP:0004050)1.66865136
101Pancytopenia (HP:0001876)1.65968499
102Microretrognathia (HP:0000308)1.65883700
103Cleft eyelid (HP:0000625)1.65317704
104Sclerocornea (HP:0000647)1.64912967
105Duplication of thumb phalanx (HP:0009942)1.63748729
106Horseshoe kidney (HP:0000085)1.62799252
107Aplasia/Hypoplasia of the ulna (HP:0006495)1.62565690
108Short nose (HP:0003196)1.61205099
109Absent forearm bone (HP:0003953)1.60437996
110Aplasia involving forearm bones (HP:0009822)1.60437996
111X-linked dominant inheritance (HP:0001423)1.59752861
112Rough bone trabeculation (HP:0100670)1.59751865
113IgM deficiency (HP:0002850)1.59750226
114Premature ovarian failure (HP:0008209)1.59688655
115Supernumerary spleens (HP:0009799)1.59367535
116Seborrheic dermatitis (HP:0001051)1.58871109
117Selective tooth agenesis (HP:0001592)1.58528385
118Aplasia/Hypoplasia of the patella (HP:0006498)1.58488542
119Hypoplasia of the ulna (HP:0003022)1.57685438
120Bilateral microphthalmos (HP:0007633)1.57683095
121Renal tubular dysfunction (HP:0000124)1.57448430
122Abnormality of the pons (HP:0007361)1.56308240
123Abnormality of the lacrimal duct (HP:0011481)1.54306841
124Abnormal urine phosphate concentration (HP:0012599)1.52661969
125Short thumb (HP:0009778)1.52371781
126Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.51994277
127Pancreatic cysts (HP:0001737)1.51173177
128Hypotrichosis (HP:0001006)1.49669578
129Abnormal respiratory motile cilium physiology (HP:0012261)1.49656260
130Abnormality of the labia minora (HP:0012880)1.49337495
131Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.48411432
132Abnormality of DNA repair (HP:0003254)1.48382632
133Pendular nystagmus (HP:0012043)1.47952684
134Anencephaly (HP:0002323)1.47695302
135Forearm undergrowth (HP:0009821)1.46952547
136Patellar aplasia (HP:0006443)1.46566306
137Abnormality of the septum pellucidum (HP:0007375)1.46552114
138Chromsome breakage (HP:0040012)1.45996978
139Abnormal sex determination (HP:0012244)1.45960838
140Sex reversal (HP:0012245)1.45960838
141Impulsivity (HP:0100710)1.45026605
142Abnormality of the 4th metacarpal (HP:0010012)1.43918350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME27.14836220
2TLK14.31176766
3VRK23.92832682
4BUB12.95553710
5LRRK22.84116740
6VRK12.83133072
7WEE12.65053403
8RPS6KB22.61468992
9NME12.54405974
10KDR2.51234641
11STK162.48551128
12MST42.38686949
13PIM22.22780973
14SRPK12.17294460
15NEK11.69060873
16TGFBR11.63975019
17ILK1.50585454
18CDK191.41312238
19BCKDK1.36802478
20EPHB21.34950782
21DYRK31.29087931
22TAF11.29083253
23MAP4K11.20825446
24PNCK1.20232451
25TYRO31.16211332
26AURKA1.15834640
27MKNK11.15051215
28PDK21.14744514
29AURKB1.11698501
30EEF2K1.11075122
31MAP2K21.09836417
32DAPK31.09434629
33CDK71.08317077
34DYRK21.07373200
35BMPR1B1.06283730
36GRK61.05151279
37MAPKAPK31.01366501
38STK391.00560405
39CDC70.98056038
40TESK20.97743617
41GRK50.97167560
42EIF2AK10.96631439
43UHMK10.95683375
44RPS6KA50.95406328
45CSNK2A20.95371143
46BRSK10.94761944
47EIF2AK30.92959811
48PIK3CA0.92129062
49ATR0.88436017
50MAPKAPK50.88145508
51TTK0.87953068
52FGR0.85351657
53CDK80.83479463
54GRK70.82561149
55GRK10.82494694
56BRAF0.82083205
57MARK30.81336377
58BLK0.80304241
59STK40.78869146
60PBK0.78498046
61PASK0.77705438
62PRKCG0.77671675
63PAK10.77133419
64CSNK2A10.76187376
65LIMK10.76095314
66EPHA20.75701199
67PIM10.75196897
68PAK20.73661679
69ADRBK10.73502496
70MAP2K70.72374689
71ABL20.71064178
72PLK10.70816904
73MAP3K110.70468510
74MST1R0.70398947
75ARAF0.68217090
76STK110.67073824
77STK100.66722440
78NTRK20.65506508
79INSRR0.63171855
80MYLK0.62344619
81PLK30.62059653
82MAP3K100.61247436
83TIE10.60957626
84CLK10.60808361
85TEC0.60773792
86TXK0.60244214
87MAP3K80.59423810
88EPHA40.58228259
89CHEK10.57713716
90PAK40.57260509
91CASK0.57133259
92NEK20.56739968
93MAPK40.56046984
94PLK40.55453949
95RPS6KA60.54567924
96NUAK10.52935980
97MAPK150.51887002
98FES0.51862862
99CDK40.51566019
100CAMK10.51346649
101WNK40.50498865
102MOS0.49642992
103NLK0.49482613
104ROCK20.48612407
105MAP3K120.48426508
106CDK20.48091693
107BTK0.47626409
108FGFR20.47176506
109MKNK20.46853595
110EIF2AK20.45874205
111IKBKB0.44921079
112PRKCI0.42846212
113WNK30.42354847
114YES10.41813330
115BRSK20.41762372
116TSSK60.41549869
117CSNK1G30.41360675
118CHEK20.41049753
119PRKACA0.40916395
120MINK10.40665334
121MATK0.39205210
122RPS6KA10.39111307
123LYN0.38698826
124STK240.38347487
125SYK0.38033893
126CDK10.37031297
127CDK30.36960044
128ACVR1B0.36476359
129MUSK0.36363706
130DYRK1B0.36113677
131TAOK30.34927555
132DMPK0.34213821
133CSNK1E0.34191555
134LCK0.34143939
135DYRK1A0.33461440
136MAP2K40.33347396
137ADRBK20.33321083
138CDK11A0.32727656
139CSNK1A10.32130480
140AKT10.31924156
141ATM0.31431473
142OBSCN0.30520180
143CAMK1D0.30263112
144ZAK0.28075063
145RPS6KC10.26890522
146RPS6KL10.26890522

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030109.61602490
2Oxidative phosphorylation_Homo sapiens_hsa001904.20965983
3Parkinsons disease_Homo sapiens_hsa050123.72542332
4RNA polymerase_Homo sapiens_hsa030203.22459582
5Proteasome_Homo sapiens_hsa030503.17631028
6Huntingtons disease_Homo sapiens_hsa050162.82701160
7Spliceosome_Homo sapiens_hsa030402.73479496
8Alzheimers disease_Homo sapiens_hsa050102.73421115
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.45801192
10DNA replication_Homo sapiens_hsa030302.41844552
11Protein export_Homo sapiens_hsa030602.27417463
12Mismatch repair_Homo sapiens_hsa034302.09733167
13Pyrimidine metabolism_Homo sapiens_hsa002402.01308708
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.94201093
15Homologous recombination_Homo sapiens_hsa034401.84845174
16Nucleotide excision repair_Homo sapiens_hsa034201.75305099
17Cardiac muscle contraction_Homo sapiens_hsa042601.56982756
18RNA transport_Homo sapiens_hsa030131.50175040
19Systemic lupus erythematosus_Homo sapiens_hsa053221.47786555
20Base excision repair_Homo sapiens_hsa034101.24120591
21Fanconi anemia pathway_Homo sapiens_hsa034601.12601058
22RNA degradation_Homo sapiens_hsa030181.11052507
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09774825
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04973016
25Basal transcription factors_Homo sapiens_hsa030220.96258872
26Non-homologous end-joining_Homo sapiens_hsa034500.94763836
27Purine metabolism_Homo sapiens_hsa002300.89903519
28Sulfur relay system_Homo sapiens_hsa041220.88422532
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.83502306
30One carbon pool by folate_Homo sapiens_hsa006700.82904756
31Alcoholism_Homo sapiens_hsa050340.81060893
32p53 signaling pathway_Homo sapiens_hsa041150.73307405
33Epstein-Barr virus infection_Homo sapiens_hsa051690.71929613
34Cell cycle_Homo sapiens_hsa041100.71522330
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65188937
36Vitamin digestion and absorption_Homo sapiens_hsa049770.62876039
37Primary immunodeficiency_Homo sapiens_hsa053400.61597632
38Caffeine metabolism_Homo sapiens_hsa002320.60996787
39Pyruvate metabolism_Homo sapiens_hsa006200.60077021
40Glutathione metabolism_Homo sapiens_hsa004800.56362682
41mRNA surveillance pathway_Homo sapiens_hsa030150.54877133
42Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54590155
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54280061
44Arachidonic acid metabolism_Homo sapiens_hsa005900.53272718
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.53248221
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.52784765
47Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50511619
48Basal cell carcinoma_Homo sapiens_hsa052170.49430421
49Asthma_Homo sapiens_hsa053100.47403642
50Hematopoietic cell lineage_Homo sapiens_hsa046400.47387060
51Fat digestion and absorption_Homo sapiens_hsa049750.46291194
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.44512825
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.41288638
54Nitrogen metabolism_Homo sapiens_hsa009100.40547140
55Linoleic acid metabolism_Homo sapiens_hsa005910.39836144
56Metabolic pathways_Homo sapiens_hsa011000.38853415
57Hedgehog signaling pathway_Homo sapiens_hsa043400.38768298
58Antigen processing and presentation_Homo sapiens_hsa046120.37822447
59Viral carcinogenesis_Homo sapiens_hsa052030.36059115
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35973747
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35832406
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.33449182
63Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.32480169
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31256649
65Ether lipid metabolism_Homo sapiens_hsa005650.31081356
66Autoimmune thyroid disease_Homo sapiens_hsa053200.30919843
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30711800
68Tyrosine metabolism_Homo sapiens_hsa003500.30609387
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30368787
70Allograft rejection_Homo sapiens_hsa053300.29937442
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.29162440
72HTLV-I infection_Homo sapiens_hsa051660.27361850
73Thyroid cancer_Homo sapiens_hsa052160.26112522
74Graft-versus-host disease_Homo sapiens_hsa053320.25319172
75Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25230539
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.25145050
77Herpes simplex infection_Homo sapiens_hsa051680.24558999
78Selenocompound metabolism_Homo sapiens_hsa004500.23942508
79Wnt signaling pathway_Homo sapiens_hsa043100.23369822
80TGF-beta signaling pathway_Homo sapiens_hsa043500.23228433
81Pathways in cancer_Homo sapiens_hsa052000.23228086
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22160361
83Phototransduction_Homo sapiens_hsa047440.21722517
84Bladder cancer_Homo sapiens_hsa052190.21336742
85Collecting duct acid secretion_Homo sapiens_hsa049660.21040675
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.20069780
87Nicotine addiction_Homo sapiens_hsa050330.19904334
88Phenylalanine metabolism_Homo sapiens_hsa003600.19659477
89Pentose phosphate pathway_Homo sapiens_hsa000300.18943470
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18869128
91Tryptophan metabolism_Homo sapiens_hsa003800.17819507
92Chemical carcinogenesis_Homo sapiens_hsa052040.17214941
93Olfactory transduction_Homo sapiens_hsa047400.16523451
94Vitamin B6 metabolism_Homo sapiens_hsa007500.16338891
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.16311665
96HIF-1 signaling pathway_Homo sapiens_hsa040660.15420391
97Retinol metabolism_Homo sapiens_hsa008300.14983078
98Peroxisome_Homo sapiens_hsa041460.14822134
99Notch signaling pathway_Homo sapiens_hsa043300.14652659
100Folate biosynthesis_Homo sapiens_hsa007900.13376519
101alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.13325710
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.13211199
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12774930
104Small cell lung cancer_Homo sapiens_hsa052220.11996765
105Sphingolipid metabolism_Homo sapiens_hsa006000.11445632
106Vibrio cholerae infection_Homo sapiens_hsa051100.11362314
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.10938504
108Rheumatoid arthritis_Homo sapiens_hsa053230.10577657
109Arginine and proline metabolism_Homo sapiens_hsa003300.10509339
110Apoptosis_Homo sapiens_hsa042100.09803816
111Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.09642038
112Hippo signaling pathway_Homo sapiens_hsa043900.09185392
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08722585
114MicroRNAs in cancer_Homo sapiens_hsa052060.08604883
115Serotonergic synapse_Homo sapiens_hsa047260.08476824
116Carbon metabolism_Homo sapiens_hsa012000.08285787
117N-Glycan biosynthesis_Homo sapiens_hsa005100.07950996
118Melanogenesis_Homo sapiens_hsa049160.07044140
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.06862691
120Biosynthesis of amino acids_Homo sapiens_hsa012300.06406332
121Malaria_Homo sapiens_hsa051440.06385349
122Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.06120481
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.06106728
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.05687231
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05649615
126Steroid biosynthesis_Homo sapiens_hsa001000.05565477
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05332816
128Tight junction_Homo sapiens_hsa045300.05317573
129Galactose metabolism_Homo sapiens_hsa000520.03174428
130Regulation of autophagy_Homo sapiens_hsa041400.02271656
131Propanoate metabolism_Homo sapiens_hsa006400.00915342
132Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.00088347
133Fatty acid elongation_Homo sapiens_hsa00062-0.0268837
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0250523
135Taurine and hypotaurine metabolism_Homo sapiens_hsa00430-0.0207438
136Butanoate metabolism_Homo sapiens_hsa00650-0.0102576

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