ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	7.65825522
2	translational termination (GO:0006415)	7.23943266
3	ribosomal small subunit assembly (GO:0000028)	7.17065566
4	ribosomal small subunit biogenesis (GO:0042274)	6.54070141
5	translational elongation (GO:0006414)	6.00477902
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.96488232
7	cotranslational protein targeting to membrane (GO:0006613)	5.86549306
8	protein targeting to ER (GO:0045047)	5.85940713
9	cellular protein complex disassembly (GO:0043624)	5.66473926
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.64756989
11	viral life cycle (GO:0019058)	5.60678224
12	protein localization to endoplasmic reticulum (GO:0070972)	5.49651678
13	maturation of SSU-rRNA (GO:0030490)	5.48404287
14	ATP synthesis coupled proton transport (GO:0015986)	5.44022062
15	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.44022062
16	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.41683140
17	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	5.07088106
18	protein complex disassembly (GO:0043241)	4.94418331
19	chaperone-mediated protein transport (GO:0072321)	4.91208876
20	macromolecular complex disassembly (GO:0032984)	4.65837451
21	pyrimidine nucleotide catabolic process (GO:0006244)	4.57129223
22	substrate-independent telencephalic tangential migration (GO:0021826)	4.50789695
23	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.50789695
24	translational initiation (GO:0006413)	4.47588087
25	behavioral response to nicotine (GO:0035095)	4.41040632
26	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.35162120
27	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.35162120
28	NADH dehydrogenase complex assembly (GO:0010257)	4.35162120
29	GTP biosynthetic process (GO:0006183)	4.34320333
30	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.11588788
31	protein complex biogenesis (GO:0070271)	4.09180608
32	protein targeting to membrane (GO:0006612)	4.04378626
33	pyrimidine nucleobase catabolic process (GO:0006208)	4.02391306
34	somite development (GO:0061053)	3.99773627
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.91677200
36	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	3.86635002
37	UTP biosynthetic process (GO:0006228)	3.77163291
38	mitochondrial respiratory chain complex assembly (GO:0033108)	3.74606395
39	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.64421783
40	cell proliferation in forebrain (GO:0021846)	3.61679976
41	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.56592312
42	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.50451318
43	UTP metabolic process (GO:0046051)	3.50436410
44	auditory receptor cell differentiation (GO:0042491)	3.46984563
45	inner mitochondrial membrane organization (GO:0007007)	3.43959831
46	translation (GO:0006412)	3.41100327
47	mRNA catabolic process (GO:0006402)	3.40634990
48	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.38637635
49	nonmotile primary cilium assembly (GO:0035058)	3.29774407
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.28575915
51	respiratory electron transport chain (GO:0022904)	3.27427500
52	neuron fate specification (GO:0048665)	3.26360592
53	regulation of protein heterodimerization activity (GO:0043497)	3.25036755
54	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.24976982
55	ovulation cycle (GO:0042698)	3.23836498
56	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	3.22310566
57	electron transport chain (GO:0022900)	3.21750968
58	cardiovascular system development (GO:0072358)	3.21148882
59	CTP metabolic process (GO:0046036)	3.19110409
60	CTP biosynthetic process (GO:0006241)	3.19110409
61	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.15761567
62	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.15546523
63	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.15546523
64	response to pheromone (GO:0019236)	3.13934318
65	positive regulation of T cell apoptotic process (GO:0070234)	3.13881843
66	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.13361859
67	axonal fasciculation (GO:0007413)	3.12827915
68	intraciliary transport (GO:0042073)	3.11182124
69	neuron fate determination (GO:0048664)	3.08766163
70	ATP biosynthetic process (GO:0006754)	3.08422046
71	nucleobase catabolic process (GO:0046113)	3.06302392
72	negative regulation of T cell differentiation in thymus (GO:0033085)	3.06124136
73	RNA catabolic process (GO:0006401)	3.02962855
74	ncRNA 3-end processing (GO:0043628)	3.01820799
75	cellular component biogenesis (GO:0044085)	3.01616451
76	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.00646313
77	neuron remodeling (GO:0016322)	2.99742085
78	positive regulation of protein homodimerization activity (GO:0090073)	2.99379654
79	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.97483283
80	protein neddylation (GO:0045116)	2.96708077
81	spinal cord association neuron differentiation (GO:0021527)	2.95161006
82	head development (GO:0060322)	2.93981038
83	water-soluble vitamin biosynthetic process (GO:0042364)	2.90775729
84	positive regulation of growth hormone secretion (GO:0060124)	2.87315398
85	protein targeting (GO:0006605)	2.84676587
86	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.84230875
87	ribonucleoprotein complex biogenesis (GO:0022613)	2.81299036
88	protein polyglutamylation (GO:0018095)	2.80683904
89	establishment of protein localization to membrane (GO:0090150)	2.78851661
90	dendritic spine morphogenesis (GO:0060997)	2.77548281
91	forebrain morphogenesis (GO:0048853)	2.76831301
92	respiratory chain complex IV assembly (GO:0008535)	2.76236265
93	transmission of nerve impulse (GO:0019226)	2.73584848
94	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	2.69428564
95	cell migration in hindbrain (GO:0021535)	2.67830767
96	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.67019248
97	neuron recognition (GO:0008038)	2.66587326
98	establishment of protein localization to organelle (GO:0072594)	2.62870316
99	nucleoside triphosphate biosynthetic process (GO:0009142)	2.62082686
100	epithelial cilium movement (GO:0003351)	2.61968214

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.27778647
2	EZH2_22144423_ChIP-Seq_EOC_Human	6.18199685
3	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.83618535
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.66501565
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.63778118
6	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.57714845
7	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.53987413
8	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.25674206
9	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.24821567
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.22417543
11	VDR_22108803_ChIP-Seq_LS180_Human	2.16892132
12	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.13558106
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.09255586
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.07028926
15	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03667098
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.95153072
17	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.94508635
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.93945697
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.93693745
20	IRF1_19129219_ChIP-ChIP_H3396_Human	1.82507677
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.72680888
22	ZNF274_21170338_ChIP-Seq_K562_Hela	1.70308191
23	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.70268185
24	RNF2_27304074_Chip-Seq_NSC_Mouse	1.68488598
25	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.67148157
26	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.66950169
27	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.65756495
28	REST_21632747_ChIP-Seq_MESCs_Mouse	1.65714825
29	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.62313065
30	XRN2_22483619_ChIP-Seq_HELA_Human	1.60008266
31	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.58943962
32	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.58943962
33	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.56797151
34	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.54824504
35	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.52917103
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.52911901
37	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.49600298
38	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.47810702
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.47588400
40	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.46880012
41	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.46649458
42	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.44192858
43	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.43859546
44	TTF2_22483619_ChIP-Seq_HELA_Human	1.38849711
45	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35558349
46	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.34033275
47	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.34018384
48	CTCF_27219007_Chip-Seq_Bcells_Human	1.31890347
49	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.28436728
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.28252286
51	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.27168723
52	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.24095636
53	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22719841
54	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.21530738
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19721177
56	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19254886
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.18211345
58	FOXP3_21729870_ChIP-Seq_TREG_Human	1.14519623
59	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.14047060
60	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.13005445
61	ERA_21632823_ChIP-Seq_H3396_Human	1.12808009
62	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.12536535
63	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.12504965
64	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.12118426
65	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.10658321
66	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.10458086
67	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10335266
68	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.09780798
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09735218
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09380302
71	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09271313
72	BCL6_27268052_Chip-Seq_Bcells_Human	1.07675197
73	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.04895182
74	P68_20966046_ChIP-Seq_HELA_Human	1.03794758
75	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03642184
76	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02890807
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.02044310
78	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01251110
79	TET1_21451524_ChIP-Seq_MESCs_Mouse	1.01236328
80	TP53_22573176_ChIP-Seq_HFKS_Human	0.99691943
81	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.99313230
82	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.99198957
83	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97922179
84	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.97696836
85	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.96818957
86	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.95199202
87	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.94704996
88	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.94662517
89	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.94492417
90	NCOR_22424771_ChIP-Seq_293T_Human	0.94275340
91	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91430306
92	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.90643771
93	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.88512066
94	E2F1_20622854_ChIP-Seq_HELA_Human	0.88031422
95	CTCF_20526341_ChIP-Seq_ESCs_Human	0.87449631
96	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.86334891
97	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.85749071
98	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.85587501
99	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.84200295
100	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.83917386

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.36591690
2	MP0006292_abnormal_olfactory_placode	4.85225140
3	MP0003123_paternal_imprinting	4.40722479
4	MP0003787_abnormal_imprinting	3.82857172
5	MP0003122_maternal_imprinting	3.37980363
6	MP0002653_abnormal_ependyma_morphology	3.03587172
7	MP0008877_abnormal_DNA_methylation	2.96919475
8	MP0003121_genomic_imprinting	2.84935003
9	MP0008789_abnormal_olfactory_epithelium	2.84269746
10	MP0002102_abnormal_ear_morphology	2.68761373
11	MP0005394_taste/olfaction_phenotype	2.58954987
12	MP0005499_abnormal_olfactory_system	2.58954987
13	MP0000778_abnormal_nervous_system	2.41166824
14	MP0005646_abnormal_pituitary_gland	2.02374791
15	MP0003315_abnormal_perineum_morphology	2.01766235
16	MP0002163_abnormal_gland_morphology	1.98401250
17	MP0000049_abnormal_middle_ear	1.94612483
18	MP0004142_abnormal_muscle_tone	1.93197916
19	MP0003880_abnormal_central_pattern	1.82933587
20	MP0001293_anophthalmia	1.78979731
21	MP0004742_abnormal_vestibular_system	1.72296680
22	MP0003136_yellow_coat_color	1.71970632
23	MP0000372_irregular_coat_pigmentation	1.56320187
24	MP0002557_abnormal_social/conspecific_i	1.51956018
25	MP0002938_white_spotting	1.50816862
26	MP0005551_abnormal_eye_electrophysiolog	1.50386549
27	MP0002638_abnormal_pupillary_reflex	1.45214827
28	MP0001485_abnormal_pinna_reflex	1.44819248
29	MP0002095_abnormal_skin_pigmentation	1.42591002
30	MP0004859_abnormal_synaptic_plasticity	1.40071611
31	MP0004885_abnormal_endolymph	1.39877957
32	MP0000955_abnormal_spinal_cord	1.33933353
33	MP0004133_heterotaxia	1.33906310
34	MP0003646_muscle_fatigue	1.32757557
35	MP0005187_abnormal_penis_morphology	1.31719262
36	MP0003938_abnormal_ear_development	1.31210642
37	MP0004145_abnormal_muscle_electrophysio	1.27612394
38	MP0001529_abnormal_vocalization	1.25329234
39	MP0002272_abnormal_nervous_system	1.25173398
40	MP0005195_abnormal_posterior_eye	1.24413425
41	MP0002752_abnormal_somatic_nervous	1.21888193
42	MP0002063_abnormal_learning/memory/cond	1.18350183
43	MP0003635_abnormal_synaptic_transmissio	1.16832380
44	MP0006276_abnormal_autonomic_nervous	1.15653675
45	MP0002572_abnormal_emotion/affect_behav	1.13147026
46	MP0006072_abnormal_retinal_apoptosis	1.12724371
47	MP0002234_abnormal_pharynx_morphology	1.11600749
48	MP0002837_dystrophic_cardiac_calcinosis	1.10184562
49	MP0002882_abnormal_neuron_morphology	1.10008548
50	MP0005423_abnormal_somatic_nervous	1.09082771
51	MP0000026_abnormal_inner_ear	1.08086697
52	MP0002184_abnormal_innervation	1.07534133
53	MP0001970_abnormal_pain_threshold	1.07311197
54	MP0002160_abnormal_reproductive_system	1.05974556
55	MP0002733_abnormal_thermal_nociception	1.05490132
56	MP0000631_abnormal_neuroendocrine_gland	1.04446498
57	MP0003942_abnormal_urinary_system	1.01570548
58	MP0002152_abnormal_brain_morphology	0.97911923
59	MP0002233_abnormal_nose_morphology	0.97666955
60	MP0001286_abnormal_eye_development	0.95912011
61	MP0002736_abnormal_nociception_after	0.95905336
62	MP0003861_abnormal_nervous_system	0.95494489
63	MP0000569_abnormal_digit_pigmentation	0.95375410
64	MP0009745_abnormal_behavioral_response	0.95008195
65	MP0003186_abnormal_redox_activity	0.93469333
66	MP0009046_muscle_twitch	0.92867297
67	MP0001502_abnormal_circadian_rhythm	0.91292135
68	MP0005389_reproductive_system_phenotype	0.90432875
69	MP0001968_abnormal_touch/_nociception	0.90125834
70	MP0002067_abnormal_sensory_capabilities	0.88190897
71	MP0002734_abnormal_mechanical_nocicepti	0.88102595
72	MP0002249_abnormal_larynx_morphology	0.87362419
73	MP0002277_abnormal_respiratory_mucosa	0.87071026
74	MP0001440_abnormal_grooming_behavior	0.86648102
75	MP0004147_increased_porphyrin_level	0.86305642
76	MP0000678_abnormal_parathyroid_gland	0.83748256
77	MP0005377_hearing/vestibular/ear_phenot	0.82877437
78	MP0003878_abnormal_ear_physiology	0.82877437
79	MP0001348_abnormal_lacrimal_gland	0.81412396
80	MP0005174_abnormal_tail_pigmentation	0.80226491
81	MP0005379_endocrine/exocrine_gland_phen	0.80040437
82	MP0003937_abnormal_limbs/digits/tail_de	0.79773222
83	MP0005253_abnormal_eye_physiology	0.78904056
84	MP0001984_abnormal_olfaction	0.78237634
85	MP0001486_abnormal_startle_reflex	0.78109709
86	MP0002210_abnormal_sex_determination	0.78033215
87	MP0001963_abnormal_hearing_physiology	0.76372344
88	MP0001905_abnormal_dopamine_level	0.75499296
89	MP0004858_abnormal_nervous_system	0.75279528
90	MP0003011_delayed_dark_adaptation	0.75135091
91	MP0001919_abnormal_reproductive_system	0.73970457
92	MP0000566_synostosis	0.72793059
93	MP0003755_abnormal_palate_morphology	0.71182704
94	MP0005391_vision/eye_phenotype	0.70876856
95	MP0002116_abnormal_craniofacial_bone	0.68896425
96	MP0002177_abnormal_outer_ear	0.68290290
97	MP0003936_abnormal_reproductive_system	0.67839883
98	MP0003879_abnormal_hair_cell	0.67754961
99	MP0004811_abnormal_neuron_physiology	0.67318316
100	MP0002064_seizures	0.63542034

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.43326669
2	Abnormality of cells of the erythroid lineage (HP:0012130)	4.45668538
3	Acute necrotizing encephalopathy (HP:0006965)	4.39264972
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.07245301
5	Acute encephalopathy (HP:0006846)	3.97766841
6	Abnormal number of erythroid precursors (HP:0012131)	3.77061881
7	Macrocytic anemia (HP:0001972)	3.67766611
8	Mitochondrial inheritance (HP:0001427)	3.51088757
9	Pancreatic fibrosis (HP:0100732)	3.51077798
10	Progressive macrocephaly (HP:0004481)	3.47369013
11	Abnormal hair whorl (HP:0010721)	3.25469556
12	Medial flaring of the eyebrow (HP:0010747)	3.20504173
13	Congenital stationary night blindness (HP:0007642)	3.18924425
14	Pallor (HP:0000980)	3.16976681
15	Myokymia (HP:0002411)	2.98584167
16	Hyperglycinemia (HP:0002154)	2.96771233
17	Type II lissencephaly (HP:0007260)	2.95980091
18	Increased CSF lactate (HP:0002490)	2.95126532
19	Gait imbalance (HP:0002141)	2.86922934
20	Hepatocellular necrosis (HP:0001404)	2.72944955
21	Congenital primary aphakia (HP:0007707)	2.66865864
22	Molar tooth sign on MRI (HP:0002419)	2.66851615
23	Abnormality of midbrain morphology (HP:0002418)	2.66851615
24	Pendular nystagmus (HP:0012043)	2.64884593
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.62117319
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.62117319
27	Cerebral edema (HP:0002181)	2.61575747
28	True hermaphroditism (HP:0010459)	2.60915508
29	Retinal dysplasia (HP:0007973)	2.54643864
30	Pancreatic cysts (HP:0001737)	2.52863922
31	Nephronophthisis (HP:0000090)	2.46907785
32	Nephrogenic diabetes insipidus (HP:0009806)	2.43124853
33	Chronic hepatic failure (HP:0100626)	2.41145022
34	Abnormality of the labia minora (HP:0012880)	2.38041741
35	Renal Fanconi syndrome (HP:0001994)	2.37747463
36	Increased intramyocellular lipid droplets (HP:0012240)	2.35475128
37	Hypogonadotrophic hypogonadism (HP:0000044)	2.33036793
38	Optic disc pallor (HP:0000543)	2.31349570
39	Asplenia (HP:0001746)	2.27838515
40	Absent thumb (HP:0009777)	2.27728142
41	Chromsome breakage (HP:0040012)	2.26968319
42	Abnormality of magnesium homeostasis (HP:0004921)	2.26922278
43	Poor coordination (HP:0002370)	2.26717413
44	Lipid accumulation in hepatocytes (HP:0006561)	2.26532211
45	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.26374297
46	Hepatic necrosis (HP:0002605)	2.26222247
47	Depressed nasal ridge (HP:0000457)	2.24362095
48	Optic nerve coloboma (HP:0000588)	2.23695783
49	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.21374928
50	Colon cancer (HP:0003003)	2.21299632
51	Abnormality of DNA repair (HP:0003254)	2.19943577
52	Increased hepatocellular lipid droplets (HP:0006565)	2.19285519
53	Impulsivity (HP:0100710)	2.16632902
54	Lissencephaly (HP:0001339)	2.15771841
55	Anencephaly (HP:0002323)	2.13939454
56	Sclerocornea (HP:0000647)	2.13337151
57	Agitation (HP:0000713)	2.09178174
58	Oligodactyly (hands) (HP:0001180)	2.08566279
59	Increased muscle lipid content (HP:0009058)	2.06070642
60	Postaxial foot polydactyly (HP:0001830)	2.05858452
61	Pachygyria (HP:0001302)	2.03477036
62	Septo-optic dysplasia (HP:0100842)	2.02405178
63	Hyperphosphatemia (HP:0002905)	2.00066698
64	Supernumerary spleens (HP:0009799)	1.98807638
65	Abnormality of the renal medulla (HP:0100957)	1.97236060
66	Absent/shortened dynein arms (HP:0200106)	1.96955549
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.96955549
68	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.96077991
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.96077991
70	Birth length less than 3rd percentile (HP:0003561)	1.95545290
71	Abnormal ciliary motility (HP:0012262)	1.95525432
72	Tachypnea (HP:0002789)	1.95493454
73	Rib fusion (HP:0000902)	1.92469179
74	Abnormal drinking behavior (HP:0030082)	1.92011758
75	Polydipsia (HP:0001959)	1.92011758
76	Congenital hepatic fibrosis (HP:0002612)	1.89682221
77	Hyperthyroidism (HP:0000836)	1.86584776
78	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.86199190
79	Adrenal hypoplasia (HP:0000835)	1.85967159
80	Cystic liver disease (HP:0006706)	1.85416672
81	Hepatoblastoma (HP:0002884)	1.84270970
82	Abnormality of the renal collecting system (HP:0004742)	1.82709929
83	Metaphyseal dysplasia (HP:0100255)	1.82293886
84	Vaginal atresia (HP:0000148)	1.81974984
85	Polyphagia (HP:0002591)	1.81925730
86	Hypomagnesemia (HP:0002917)	1.80936671
87	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80150199
88	Postaxial hand polydactyly (HP:0001162)	1.79514322
89	3-Methylglutaconic aciduria (HP:0003535)	1.79489580
90	Hypoplasia of the radius (HP:0002984)	1.79419201
91	Abnormality of glycine metabolism (HP:0010895)	1.78721693
92	Abnormality of serine family amino acid metabolism (HP:0010894)	1.78721693
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.78486526
94	Chorioretinal atrophy (HP:0000533)	1.78185835
95	Amblyopia (HP:0000646)	1.77849919
96	Progressive cerebellar ataxia (HP:0002073)	1.75166032
97	Leukodystrophy (HP:0002415)	1.73747375
98	Concave nail (HP:0001598)	1.73305617
99	Hyperglycinuria (HP:0003108)	1.73071624
100	Optic nerve hypoplasia (HP:0000609)	1.73037287

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK16	3.36340660
2	MAP3K11	3.11843815
3	EPHB2	2.66392460
4	WNK4	2.60508636
5	TYRO3	2.49940768
6	BCKDK	2.43067310
7	EPHA4	2.41476863
8	MAP4K2	2.22942242
9	DYRK2	2.12818738
10	MAP3K4	2.08984792
11	NEK1	2.04495319
12	MARK2	1.94178004
13	CDK19	1.87329477
14	PIK3CA	1.87040830
15	NME2	1.82894476
16	MAP2K7	1.80783562
17	CAMKK2	1.78635941
18	NEK2	1.77059492
19	DMPK	1.73386477
20	CASK	1.68307645
21	ZAK	1.67917899
22	CAMK1D	1.67513510
23	LRRK2	1.61890514
24	AURKA	1.57090657
25	TXK	1.54449095
26	NTRK2	1.53461781
27	NUAK1	1.48674508
28	MAPK15	1.47811018
29	MARK1	1.47421841
30	CAMK1	1.40128016
31	TIE1	1.39976688
32	CAMK1G	1.37836420
33	PINK1	1.23147031
34	GRK1	1.18300628
35	MAPK13	1.16695515
36	CAMKK1	1.12956124
37	PTK6	1.11574569
38	PAK3	1.09022209
39	ADRBK2	1.08995123
40	NTRK3	1.08495187
41	CDC7	1.04892366
42	MAP2K4	1.02487878
43	MINK1	1.02076539
44	PRKCG	1.00950895
45	DYRK1B	0.99325336
46	PLK1	0.97853335
47	BRSK1	0.96968851
48	STK11	0.95916540
49	AURKB	0.94682728
50	SIK2	0.93254664
51	TLK1	0.91884861
52	VRK2	0.87625668
53	PRKCZ	0.80989647
54	CAMK4	0.80113398
55	MAP4K1	0.79665582
56	DYRK3	0.78803627
57	TAOK1	0.71394890
58	CHEK2	0.69202912
59	PNCK	0.68336389
60	PKN1	0.67427361
61	CSNK1G2	0.65569925
62	CSNK1E	0.63948937
63	VRK1	0.62626870
64	ABL2	0.61952407
65	CSNK2A2	0.61902343
66	PRKACA	0.61886980
67	LIMK1	0.60673142
68	ADRBK1	0.60460639
69	DAPK2	0.60398634
70	PLK2	0.59875938
71	WNK3	0.58777324
72	INSRR	0.57922180
73	DYRK1A	0.56171548
74	ATR	0.55790483
75	NME1	0.55106820
76	ILK	0.53993402
77	PRKD2	0.53609465
78	PIM2	0.53572966
79	DAPK3	0.53209679
80	PRKCI	0.49496805
81	CSNK2A1	0.46453544
82	BMPR1B	0.45344133
83	PRKCH	0.44288846
84	CDK14	0.43899564
85	BRAF	0.43893218
86	PLK4	0.43182218
87	PRKDC	0.41695106
88	ERBB2	0.39596596
89	IRAK1	0.38029891
90	CDK5	0.37921158
91	BTK	0.37782313
92	PRKCD	0.37664354
93	CDK11A	0.37129134
94	PRKACB	0.36708748
95	TNIK	0.36545619
96	CSNK1A1	0.36339222
97	MARK3	0.35975635
98	FES	0.35915131
99	SIK1	0.35530403
100	STK39	0.35448984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.76827545
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.20088849
3	Sulfur relay system_Homo sapiens_hsa04122	3.97275714
4	Parkinsons disease_Homo sapiens_hsa05012	3.67948715
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.41299432
6	Huntingtons disease_Homo sapiens_hsa05016	2.81541139
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.62906752
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.50354406
9	Alzheimers disease_Homo sapiens_hsa05010	2.40398146
10	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.26778630
11	RNA polymerase_Homo sapiens_hsa03020	2.08483175
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.88486068
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.86368215
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.82648936
15	Pyrimidine metabolism_Homo sapiens_hsa00240	1.69381121
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.59688898
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.58177076
18	Nicotine addiction_Homo sapiens_hsa05033	1.51306827
19	Protein export_Homo sapiens_hsa03060	1.37669414
20	Butanoate metabolism_Homo sapiens_hsa00650	1.31740897
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.30008732
22	Basal transcription factors_Homo sapiens_hsa03022	1.29364458
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.29071326
24	Phototransduction_Homo sapiens_hsa04744	1.23343250
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.11477973
26	Axon guidance_Homo sapiens_hsa04360	1.08592605
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08226159
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.06694335
29	Homologous recombination_Homo sapiens_hsa03440	1.01255848
30	Ether lipid metabolism_Homo sapiens_hsa00565	1.00702594
31	Steroid biosynthesis_Homo sapiens_hsa00100	1.00530723
32	Peroxisome_Homo sapiens_hsa04146	0.97344984
33	Folate biosynthesis_Homo sapiens_hsa00790	0.95825374
34	Nucleotide excision repair_Homo sapiens_hsa03420	0.88658802
35	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.86325160
36	Tyrosine metabolism_Homo sapiens_hsa00350	0.86093417
37	Metabolic pathways_Homo sapiens_hsa01100	0.81212286
38	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.80779252
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.80130448
40	RNA degradation_Homo sapiens_hsa03018	0.78738054
41	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77232015
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.75292307
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.73502755
44	Purine metabolism_Homo sapiens_hsa00230	0.71655191
45	Glutamatergic synapse_Homo sapiens_hsa04724	0.71389717
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.70216000
47	Insulin secretion_Homo sapiens_hsa04911	0.69877536
48	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.67658668
49	Cocaine addiction_Homo sapiens_hsa05030	0.65884137
50	Morphine addiction_Homo sapiens_hsa05032	0.64435274
51	Proteasome_Homo sapiens_hsa03050	0.58760969
52	Base excision repair_Homo sapiens_hsa03410	0.56849652
53	Basal cell carcinoma_Homo sapiens_hsa05217	0.56116609
54	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55844344
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.54843204
56	Notch signaling pathway_Homo sapiens_hsa04330	0.54412173
57	Fat digestion and absorption_Homo sapiens_hsa04975	0.53701714
58	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51661558
59	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.51283011
60	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.50910007
61	Spliceosome_Homo sapiens_hsa03040	0.49763589
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48315388
63	GABAergic synapse_Homo sapiens_hsa04727	0.47279901
64	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.46677463
65	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.43582790
66	Alcoholism_Homo sapiens_hsa05034	0.43336770
67	Chemical carcinogenesis_Homo sapiens_hsa05204	0.42925189
68	DNA replication_Homo sapiens_hsa03030	0.40919913
69	Olfactory transduction_Homo sapiens_hsa04740	0.40155802
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39389033
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.37993391
72	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.37743480
73	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.37322747
74	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37172501
75	Caffeine metabolism_Homo sapiens_hsa00232	0.36779274
76	MAPK signaling pathway_Homo sapiens_hsa04010	0.36561891
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.36527678
78	Dopaminergic synapse_Homo sapiens_hsa04728	0.34996822
79	Retinol metabolism_Homo sapiens_hsa00830	0.34409123
80	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34111228
81	Hippo signaling pathway_Homo sapiens_hsa04390	0.33824596
82	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.33824057
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33587428
84	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.33335921
85	beta-Alanine metabolism_Homo sapiens_hsa00410	0.33108923
86	One carbon pool by folate_Homo sapiens_hsa00670	0.31954484
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.31066399
88	RNA transport_Homo sapiens_hsa03013	0.30377327
89	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.27634353
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.27520190
91	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.27282091
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.27189800
93	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25734150
94	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.25446470
95	Fatty acid degradation_Homo sapiens_hsa00071	0.25424018
96	p53 signaling pathway_Homo sapiens_hsa04115	0.24525012
97	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.24038931
98	Melanoma_Homo sapiens_hsa05218	0.23944293
99	Propanoate metabolism_Homo sapiens_hsa00640	0.22822574
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.22479528

RPL38P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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