ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.14585874
2	translational termination (GO:0006415)	8.77915271
3	ribosomal small subunit assembly (GO:0000028)	8.45482889
4	ribosomal small subunit biogenesis (GO:0042274)	7.85041280
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.22740343
6	translational elongation (GO:0006414)	7.19448419
7	cotranslational protein targeting to membrane (GO:0006613)	7.13704881
8	protein targeting to ER (GO:0045047)	7.07232788
9	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.80744557
10	cellular protein complex disassembly (GO:0043624)	6.79429331
11	protein localization to endoplasmic reticulum (GO:0070972)	6.65160405
12	viral life cycle (GO:0019058)	6.55172329
13	maturation of SSU-rRNA (GO:0030490)	6.52071565
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.48896717
15	protein complex disassembly (GO:0043241)	5.89695277
16	translational initiation (GO:0006413)	5.70433603
17	macromolecular complex disassembly (GO:0032984)	5.64682279
18	protein targeting to membrane (GO:0006612)	4.89584517
19	behavioral response to nicotine (GO:0035095)	4.62899882
20	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.37157304
21	cardiovascular system development (GO:0072358)	4.28582040
22	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.16438417
23	mRNA catabolic process (GO:0006402)	4.15671099
24	substrate-independent telencephalic tangential migration (GO:0021826)	4.03400528
25	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.03400528
26	auditory receptor cell differentiation (GO:0042491)	4.00208302
27	ribosomal large subunit biogenesis (GO:0042273)	3.99782027
28	neuron fate determination (GO:0048664)	3.98693739
29	translation (GO:0006412)	3.96126406
30	regulation of glycogen (starch) synthase activity (GO:2000465)	3.94537519
31	body morphogenesis (GO:0010171)	3.86162217
32	ATP synthesis coupled proton transport (GO:0015986)	3.78622929
33	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.78622929
34	cell proliferation in forebrain (GO:0021846)	3.77941519
35	pyrimidine nucleobase catabolic process (GO:0006208)	3.76227708
36	epithelial cilium movement (GO:0003351)	3.74856529
37	RNA catabolic process (GO:0006401)	3.73742538
38	pattern specification involved in kidney development (GO:0061004)	3.73047850
39	tongue development (GO:0043586)	3.72690917
40	embryonic body morphogenesis (GO:0010172)	3.69516094
41	left/right pattern formation (GO:0060972)	3.60212700
42	ribonucleoprotein complex biogenesis (GO:0022613)	3.58959339
43	GTP biosynthetic process (GO:0006183)	3.57260252
44	negative regulation of telomere maintenance (GO:0032205)	3.37450563
45	hypothalamus development (GO:0021854)	3.35348434
46	establishment of protein localization to membrane (GO:0090150)	3.32034875
47	axon ensheathment in central nervous system (GO:0032291)	3.29708125
48	central nervous system myelination (GO:0022010)	3.29708125
49	intraciliary transport (GO:0042073)	3.29010350
50	head development (GO:0060322)	3.28179408
51	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.23956756
52	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.22825378
53	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.22073355
54	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.19636279
55	UTP biosynthetic process (GO:0006228)	3.16677457
56	cellular component biogenesis (GO:0044085)	3.13522254
57	water-soluble vitamin biosynthetic process (GO:0042364)	3.12123627
58	short-term memory (GO:0007614)	3.09862956
59	protein targeting (GO:0006605)	3.07919838
60	chaperone-mediated protein transport (GO:0072321)	3.06029506
61	axonemal dynein complex assembly (GO:0070286)	3.02075663
62	somite development (GO:0061053)	3.02020798
63	spinal cord association neuron differentiation (GO:0021527)	3.00091427
64	UTP metabolic process (GO:0046051)	3.00019268
65	postsynaptic membrane organization (GO:0001941)	2.98767440
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.93909811
67	nucleobase catabolic process (GO:0046113)	2.91118869
68	myoblast migration (GO:0051451)	2.90649965
69	establishment of protein localization to organelle (GO:0072594)	2.90535835
70	cilium movement (GO:0003341)	2.90495960
71	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.89183958
72	nephron tubule morphogenesis (GO:0072078)	2.86098808
73	nephron epithelium morphogenesis (GO:0072088)	2.86098808
74	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.84965114
75	retinal ganglion cell axon guidance (GO:0031290)	2.83932587
76	motile cilium assembly (GO:0044458)	2.83120045
77	respiratory electron transport chain (GO:0022904)	2.81394356
78	neurofilament cytoskeleton organization (GO:0060052)	2.79696891
79	genetic imprinting (GO:0071514)	2.77588821
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.76981338
81	electron transport chain (GO:0022900)	2.76565167
82	protein localization to membrane (GO:0072657)	2.75624507
83	CTP metabolic process (GO:0046036)	2.74568254
84	CTP biosynthetic process (GO:0006241)	2.74568254
85	positive regulation of respiratory burst (GO:0060267)	2.73798023
86	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.66493890
87	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.66493890
88	NADH dehydrogenase complex assembly (GO:0010257)	2.66493890
89	resolution of meiotic recombination intermediates (GO:0000712)	2.66370985
90	neuronal stem cell maintenance (GO:0097150)	2.65158483
91	rRNA catabolic process (GO:0016075)	2.64638799
92	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.64302195
93	protein polyglutamylation (GO:0018095)	2.63690709
94	cardiac left ventricle morphogenesis (GO:0003214)	2.63457256
95	segment specification (GO:0007379)	2.62686264
96	establishment of mitochondrion localization (GO:0051654)	2.61424413
97	arginine catabolic process (GO:0006527)	2.61184394
98	cerebral cortex radially oriented cell migration (GO:0021799)	2.60437874
99	ncRNA catabolic process (GO:0034661)	2.57372841
100	telencephalon development (GO:0021537)	2.54900517

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	6.58397092
2	EZH2_22144423_ChIP-Seq_EOC_Human	6.50257796
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.55986422
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	3.51898659
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.71882006
6	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.35805351
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.25764163
8	EZH2_27294783_Chip-Seq_ESCs_Mouse	2.22441901
9	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.18527192
10	VDR_22108803_ChIP-Seq_LS180_Human	2.15873418
11	SUZ12_27294783_Chip-Seq_ESCs_Mouse	2.15353815
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03862056
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.99316122
14	REST_21632747_ChIP-Seq_MESCs_Mouse	1.95634465
15	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.91842173
16	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.90510924
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.86920827
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.85246733
19	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.82429899
20	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.79261360
21	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.75762445
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.59921086
23	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.59101247
24	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.58735593
25	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.54606903
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.54606903
27	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.54503790
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.54226693
29	RNF2_27304074_Chip-Seq_NSC_Mouse	1.53372162
30	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.52734995
31	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.50735126
32	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.46218977
33	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.44917855
34	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.44348228
35	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.40632385
36	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.40311929
37	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.39525015
38	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.36384888
39	XRN2_22483619_ChIP-Seq_HELA_Human	1.36329190
40	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.33014435
41	IGF1R_20145208_ChIP-Seq_DFB_Human	1.31656498
42	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.29793476
43	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.27843650
44	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.26945539
45	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.26805088
46	CTCF_27219007_Chip-Seq_Bcells_Human	1.25713489
47	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.24279531
48	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.23981451
49	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.22369416
50	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.22156461
51	ZNF274_21170338_ChIP-Seq_K562_Hela	1.21957305
52	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.20924726
53	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.20321827
54	ERA_21632823_ChIP-Seq_H3396_Human	1.19984245
55	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.16966035
56	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.16885721
57	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.16668710
58	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.15747509
59	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.12355655
60	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.12121199
61	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.11739449
62	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11624230
63	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.07830562
64	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06507013
65	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.05233014
66	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.04216924
67	GABP_19822575_ChIP-Seq_HepG2_Human	1.03601754
68	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.02378987
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01925406
70	MYC_18940864_ChIP-ChIP_HL60_Human	1.01248232
71	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.01027185
72	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00870076
73	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.00679327
74	TTF2_22483619_ChIP-Seq_HELA_Human	1.00408687
75	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.98963830
76	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.98879935
77	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.98688988
78	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.98397083
79	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.98235211
80	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.97629294
81	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97267001
82	OCT4_19829295_ChIP-Seq_ESCs_Human	0.96600091
83	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.96452267
84	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.96093645
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95461720
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.92108159
87	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91814409
88	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.91215258
89	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.91115877
90	NCOR_22424771_ChIP-Seq_293T_Human	0.90062208
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.89758604
92	CTCF_20526341_ChIP-Seq_ESCs_Human	0.89684051
93	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.88542148
94	NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse	0.88476792
95	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.88055167
96	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.87883980
97	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.87529754
98	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.85004715
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.84058534
100	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.83513254

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.05891959
2	MP0006292_abnormal_olfactory_placode	4.60309320
3	MP0003136_yellow_coat_color	3.46350367
4	MP0002653_abnormal_ependyma_morphology	3.42852930
5	MP0003123_paternal_imprinting	3.27597810
6	MP0003787_abnormal_imprinting	3.16520898
7	MP0003122_maternal_imprinting	3.09997125
8	MP0002822_catalepsy	2.27021248
9	MP0001293_anophthalmia	2.26821533
10	MP0006276_abnormal_autonomic_nervous	2.25794623
11	MP0008877_abnormal_DNA_methylation	2.25598380
12	MP0003121_genomic_imprinting	2.24288605
13	MP0003878_abnormal_ear_physiology	2.23698860
14	MP0005377_hearing/vestibular/ear_phenot	2.23698860
15	MP0008789_abnormal_olfactory_epithelium	2.16807911
16	MP0000778_abnormal_nervous_system	2.01800603
17	MP0004142_abnormal_muscle_tone	2.00520198
18	MP0002163_abnormal_gland_morphology	1.91597882
19	MP0001968_abnormal_touch/_nociception	1.83945272
20	MP0005394_taste/olfaction_phenotype	1.78679308
21	MP0005499_abnormal_olfactory_system	1.78679308
22	MP0001485_abnormal_pinna_reflex	1.77683658
23	MP0000631_abnormal_neuroendocrine_gland	1.75558076
24	MP0000049_abnormal_middle_ear	1.72691254
25	MP0001188_hyperpigmentation	1.63861385
26	MP0002938_white_spotting	1.58392674
27	MP0002733_abnormal_thermal_nociception	1.48845315
28	MP0004133_heterotaxia	1.46032602
29	MP0004145_abnormal_muscle_electrophysio	1.45275395
30	MP0003646_muscle_fatigue	1.45227952
31	MP0002272_abnormal_nervous_system	1.43710228
32	MP0002736_abnormal_nociception_after	1.40895229
33	MP0005646_abnormal_pituitary_gland	1.38567813
34	MP0002837_dystrophic_cardiac_calcinosis	1.38342721
35	MP0004742_abnormal_vestibular_system	1.35928592
36	MP0003942_abnormal_urinary_system	1.35555044
37	MP0001986_abnormal_taste_sensitivity	1.33210251
38	MP0002095_abnormal_skin_pigmentation	1.29859101
39	MP0004885_abnormal_endolymph	1.29383517
40	MP0003880_abnormal_central_pattern	1.28112699
41	MP0002735_abnormal_chemical_nociception	1.27385473
42	MP0001970_abnormal_pain_threshold	1.26210571
43	MP0002557_abnormal_social/conspecific_i	1.26020435
44	MP0002638_abnormal_pupillary_reflex	1.25579896
45	MP0004147_increased_porphyrin_level	1.22748993
46	MP0005174_abnormal_tail_pigmentation	1.20681421
47	MP0000955_abnormal_spinal_cord	1.20630760
48	MP0005084_abnormal_gallbladder_morpholo	1.19367845
49	MP0005195_abnormal_posterior_eye	1.19320242
50	MP0001440_abnormal_grooming_behavior	1.16678382
51	MP0001286_abnormal_eye_development	1.15621247
52	MP0001486_abnormal_startle_reflex	1.14591181
53	MP0002063_abnormal_learning/memory/cond	1.13866033
54	MP0003938_abnormal_ear_development	1.13028656
55	MP0010030_abnormal_orbit_morphology	1.11480652
56	MP0003635_abnormal_synaptic_transmissio	1.11230572
57	MP0002572_abnormal_emotion/affect_behav	1.10005270
58	MP0001529_abnormal_vocalization	1.08394084
59	MP0002277_abnormal_respiratory_mucosa	1.07743828
60	MP0000569_abnormal_digit_pigmentation	1.07613461
61	MP0009745_abnormal_behavioral_response	1.07575422
62	MP0002249_abnormal_larynx_morphology	1.06390845
63	MP0002876_abnormal_thyroid_physiology	1.06161579
64	MP0001324_abnormal_eye_pigmentation	1.05782907
65	MP0002752_abnormal_somatic_nervous	1.04687106
66	MP0003011_delayed_dark_adaptation	1.02193693
67	MP0003879_abnormal_hair_cell	1.02175430
68	MP0000372_irregular_coat_pigmentation	1.01402126
69	MP0002233_abnormal_nose_morphology	1.00120079
70	MP0003755_abnormal_palate_morphology	0.99669421
71	MP0009046_muscle_twitch	0.97287876
72	MP0000026_abnormal_inner_ear	0.96935633
73	MP0002067_abnormal_sensory_capabilities	0.95462644
74	MP0002928_abnormal_bile_duct	0.94799216
75	MP0000566_synostosis	0.91647076
76	MP0002160_abnormal_reproductive_system	0.91216588
77	MP0002697_abnormal_eye_size	0.90996564
78	MP0002152_abnormal_brain_morphology	0.89605666
79	MP0005645_abnormal_hypothalamus_physiol	0.87688807
80	MP0002734_abnormal_mechanical_nocicepti	0.87500578
81	MP0005551_abnormal_eye_electrophysiolog	0.86339212
82	MP0001905_abnormal_dopamine_level	0.85206586
83	MP0002882_abnormal_neuron_morphology	0.84735985
84	MP0003937_abnormal_limbs/digits/tail_de	0.84566558
85	MP0002184_abnormal_innervation	0.84450665
86	MP0002064_seizures	0.84364845
87	MP0001963_abnormal_hearing_physiology	0.83130708
88	MP0002102_abnormal_ear_morphology	0.83082737
89	MP0002092_abnormal_eye_morphology	0.82858581
90	MP0003861_abnormal_nervous_system	0.82674660
91	MP0002138_abnormal_hepatobiliary_system	0.80904023
92	MP0005379_endocrine/exocrine_gland_phen	0.80412651
93	MP0008872_abnormal_physiological_respon	0.80285938
94	MP0003567_abnormal_fetal_cardiomyocyte	0.79477635
95	MP0001984_abnormal_olfaction	0.78921766
96	MP0002234_abnormal_pharynx_morphology	0.77980664
97	MP0005391_vision/eye_phenotype	0.77623267
98	MP0008875_abnormal_xenobiotic_pharmacok	0.76856033
99	MP0005389_reproductive_system_phenotype	0.73811685
100	MP0002116_abnormal_craniofacial_bone	0.70796786

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.94907911
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.17227708
3	Pancreatic fibrosis (HP:0100732)	4.17388467
4	Macrocytic anemia (HP:0001972)	3.89207128
5	Acute necrotizing encephalopathy (HP:0006965)	3.88031640
6	Abnormality of midbrain morphology (HP:0002418)	3.75773276
7	Molar tooth sign on MRI (HP:0002419)	3.75773276
8	Septo-optic dysplasia (HP:0100842)	3.68491260
9	Acute encephalopathy (HP:0006846)	3.44901316
10	Abnormal mitochondria in muscle tissue (HP:0008316)	3.35237232
11	Colon cancer (HP:0003003)	3.34030884
12	Pallor (HP:0000980)	3.32091895
13	Nephronophthisis (HP:0000090)	3.31024639
14	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.27010960
15	Absent/shortened dynein arms (HP:0200106)	3.27010960
16	Absent thumb (HP:0009777)	3.22502818
17	Abnormal number of erythroid precursors (HP:0012131)	3.16854160
18	True hermaphroditism (HP:0010459)	3.14120089
19	Sclerocornea (HP:0000647)	3.03990693
20	Rib fusion (HP:0000902)	2.99302169
21	Stenosis of the external auditory canal (HP:0000402)	2.99159615
22	Pancreatic cysts (HP:0001737)	2.94657132
23	Progressive macrocephaly (HP:0004481)	2.94097767
24	Tubular atrophy (HP:0000092)	2.93129026
25	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.87401335
26	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.87246151
27	Asplenia (HP:0001746)	2.82479097
28	Hyperglycinemia (HP:0002154)	2.80759148
29	Anencephaly (HP:0002323)	2.77671455
30	Medial flaring of the eyebrow (HP:0010747)	2.75438571
31	Mitochondrial inheritance (HP:0001427)	2.68925706
32	Chronic hepatic failure (HP:0100626)	2.66277451
33	Abnormality of the labia minora (HP:0012880)	2.65416930
34	Depressed nasal ridge (HP:0000457)	2.63496274
35	Maternal diabetes (HP:0009800)	2.60992586
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.57651166
37	Partial duplication of thumb phalanx (HP:0009944)	2.56817435
38	Hip dysplasia (HP:0001385)	2.56560916
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.55618499
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.55618499
41	Abnormality of the renal medulla (HP:0100957)	2.52601222
42	Adrenal hypoplasia (HP:0000835)	2.49966403
43	Hyperthyroidism (HP:0000836)	2.49770710
44	Cystic liver disease (HP:0006706)	2.49375065
45	Myokymia (HP:0002411)	2.48915890
46	Anophthalmia (HP:0000528)	2.45715175
47	Supernumerary spleens (HP:0009799)	2.41107874
48	Abnormal ciliary motility (HP:0012262)	2.37165836
49	Optic nerve hypoplasia (HP:0000609)	2.34109829
50	Abnormality of the 4th metacarpal (HP:0010012)	2.27741752
51	Bile duct proliferation (HP:0001408)	2.27675034
52	Abnormal biliary tract physiology (HP:0012439)	2.27675034
53	Postaxial foot polydactyly (HP:0001830)	2.27540971
54	Flat capital femoral epiphysis (HP:0003370)	2.25630504
55	Polyphagia (HP:0002591)	2.22839364
56	Optic disc pallor (HP:0000543)	2.21788952
57	Cerebral edema (HP:0002181)	2.20379237
58	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.19588426
59	Gait imbalance (HP:0002141)	2.19325371
60	Type II lissencephaly (HP:0007260)	2.16367258
61	Oligodactyly (hands) (HP:0001180)	2.14365697
62	11 pairs of ribs (HP:0000878)	2.12832056
63	Increased CSF lactate (HP:0002490)	2.12681713
64	Pendular nystagmus (HP:0012043)	2.09567303
65	Absent septum pellucidum (HP:0001331)	2.07197771
66	Growth hormone deficiency (HP:0000824)	2.06912922
67	Abnormality of the diencephalon (HP:0010662)	2.06766732
68	Partial duplication of the phalanx of hand (HP:0009999)	2.05546713
69	Cerebral hypomyelination (HP:0006808)	2.01448880
70	Oligodactyly (HP:0012165)	1.99656384
71	Hypoplasia of the ulna (HP:0003022)	1.98885660
72	Congenital primary aphakia (HP:0007707)	1.98601774
73	Hypoplasia of the radius (HP:0002984)	1.98375776
74	Abnormal rod and cone electroretinograms (HP:0008323)	1.98309731
75	Optic nerve coloboma (HP:0000588)	1.97057746
76	Nephrogenic diabetes insipidus (HP:0009806)	1.96912831
77	Agitation (HP:0000713)	1.95267986
78	Limb dystonia (HP:0002451)	1.92532877
79	Holoprosencephaly (HP:0001360)	1.91431944
80	Male pseudohermaphroditism (HP:0000037)	1.90294554
81	Abnormal hair whorl (HP:0010721)	1.88189113
82	Concave nail (HP:0001598)	1.86672531
83	Occipital encephalocele (HP:0002085)	1.84630502
84	Poor suck (HP:0002033)	1.83370522
85	Congenital hepatic fibrosis (HP:0002612)	1.83200880
86	Abnormality of DNA repair (HP:0003254)	1.82399418
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82024576
88	Deep palmar crease (HP:0006191)	1.81427065
89	Tubulointerstitial nephritis (HP:0001970)	1.81114791
90	Annular pancreas (HP:0001734)	1.80635149
91	Retinal dysplasia (HP:0007973)	1.80592750
92	Abnormal respiratory motile cilium physiology (HP:0012261)	1.79910322
93	Esophageal atresia (HP:0002032)	1.79838070
94	Hepatoblastoma (HP:0002884)	1.78944066
95	Narrow forehead (HP:0000341)	1.77583755
96	Duplication of thumb phalanx (HP:0009942)	1.77177642
97	Postaxial hand polydactyly (HP:0001162)	1.74976327
98	Forearm undergrowth (HP:0009821)	1.74231911
99	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.73689851
100	Bony spicule pigmentary retinopathy (HP:0007737)	1.71163248

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.88587883
2	STK16	3.61483508
3	DYRK2	2.96314888
4	LRRK2	2.52005941
5	CDK19	2.37921894
6	TYRO3	2.37895862
7	STK39	2.30232132
8	MAP2K7	2.28241251
9	CASK	2.20519138
10	MAP3K11	2.05806509
11	PINK1	2.04294203
12	WNK1	1.75152716
13	PRKCH	1.73733266
14	BCKDK	1.72230217
15	BRAF	1.68172096
16	PRKCG	1.65425371
17	PIK3CA	1.61224300
18	CAMK1D	1.58330985
19	MAP4K2	1.47318766
20	EPHA4	1.47080917
21	EPHB2	1.45310857
22	PAK3	1.43828790
23	TLK1	1.42214198
24	CAMKK2	1.35378319
25	MAPK15	1.34864307
26	ARAF	1.33923469
27	GRK1	1.31291927
28	PRKD3	1.31137114
29	MARK1	1.30865620
30	NTRK3	1.30249133
31	CAMK1	1.29087805
32	CAMK1G	1.28875941
33	DYRK1B	1.19150622
34	MAP2K4	1.10792898
35	DYRK3	1.07745838
36	MAP3K4	1.07517400
37	LIMK1	1.05727635
38	CSNK1E	1.03027687
39	TIE1	1.01174598
40	AURKA	1.00851586
41	MAPK13	1.00023871
42	MINK1	0.98667804
43	TNIK	0.95735226
44	CAMKK1	0.94666634
45	PRKCQ	0.92679750
46	SGK1	0.89997119
47	NUAK1	0.89779070
48	NTRK2	0.85609951
49	SGK223	0.85495995
50	SGK494	0.85495995
51	VRK2	0.83918215
52	NME2	0.83813868
53	STK11	0.82297535
54	DYRK1A	0.80693587
55	ADRBK2	0.79302992
56	CDC7	0.77364708
57	PNCK	0.77050706
58	WNK3	0.76845009
59	DAPK3	0.76084323
60	CSNK2A2	0.75812045
61	PRKCZ	0.75583840
62	MAP3K9	0.73446059
63	AURKB	0.70300604
64	BTK	0.70269760
65	NEK1	0.69874023
66	STK24	0.69689157
67	TAF1	0.68683210
68	PRKACA	0.66197533
69	SGK3	0.64324942
70	TRIM28	0.62028018
71	ADRBK1	0.59469380
72	INSRR	0.59069580
73	CSNK1G2	0.58028536
74	PRKCD	0.56691179
75	RPS6KA6	0.55682356
76	PRKCE	0.54807791
77	CSNK1A1	0.54721701
78	PRKCI	0.53275439
79	ABL2	0.51746730
80	VRK1	0.51676880
81	PHKG2	0.49641248
82	PHKG1	0.49641248
83	ZAK	0.49484911
84	MKNK2	0.48657313
85	OXSR1	0.46222283
86	STK38L	0.44502851
87	PRKD2	0.44070981
88	NEK2	0.43820696
89	CSNK1G3	0.43662492
90	PRKAA2	0.42891236
91	CDK5	0.42339143
92	TEC	0.41427924
93	CDK11A	0.41260705
94	PLK4	0.40687452
95	PRKDC	0.40035548
96	AKT1	0.39845347
97	RPS6KL1	0.39382912
98	RPS6KC1	0.39382912
99	PIM2	0.38578081
100	MAP3K12	0.38378123

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	8.20245498
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.67891918
3	Parkinsons disease_Homo sapiens_hsa05012	3.35317244
4	Sulfur relay system_Homo sapiens_hsa04122	3.08745009
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.83026278
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.57804370
7	Alzheimers disease_Homo sapiens_hsa05010	2.34264603
8	Huntingtons disease_Homo sapiens_hsa05016	2.32121049
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.21342609
10	Linoleic acid metabolism_Homo sapiens_hsa00591	1.97210859
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.92534557
12	Protein export_Homo sapiens_hsa03060	1.90810864
13	Basal cell carcinoma_Homo sapiens_hsa05217	1.87324637
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.76222624
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.75008000
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.68308503
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.66174215
18	Nicotine addiction_Homo sapiens_hsa05033	1.62818377
19	Notch signaling pathway_Homo sapiens_hsa04330	1.62516841
20	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.58900165
21	Basal transcription factors_Homo sapiens_hsa03022	1.52898375
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.27973217
23	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.27538358
24	Butanoate metabolism_Homo sapiens_hsa00650	1.26474798
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.17443587
26	Propanoate metabolism_Homo sapiens_hsa00640	1.06706623
27	Morphine addiction_Homo sapiens_hsa05032	1.03880329
28	Homologous recombination_Homo sapiens_hsa03440	1.00841632
29	RNA polymerase_Homo sapiens_hsa03020	1.00229774
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.00134146
31	Glutamatergic synapse_Homo sapiens_hsa04724	1.00050184
32	RNA degradation_Homo sapiens_hsa03018	0.97879609
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96987032
34	Ether lipid metabolism_Homo sapiens_hsa00565	0.96857144
35	Tryptophan metabolism_Homo sapiens_hsa00380	0.95727395
36	Axon guidance_Homo sapiens_hsa04360	0.92662824
37	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90920769
38	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89278136
39	Nitrogen metabolism_Homo sapiens_hsa00910	0.84757449
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83487782
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.82413481
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.79115387
43	Fat digestion and absorption_Homo sapiens_hsa04975	0.78820244
44	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.76988914
45	One carbon pool by folate_Homo sapiens_hsa00670	0.76222621
46	GABAergic synapse_Homo sapiens_hsa04727	0.75850483
47	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.73919151
48	Metabolic pathways_Homo sapiens_hsa01100	0.73797228
49	Serotonergic synapse_Homo sapiens_hsa04726	0.73746350
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.71887728
51	Phototransduction_Homo sapiens_hsa04744	0.71650540
52	Insulin secretion_Homo sapiens_hsa04911	0.70561855
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.64729877
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.64583111
55	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.64190687
56	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61572614
57	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.60108067
58	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.59923780
59	Purine metabolism_Homo sapiens_hsa00230	0.59696637
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.59246426
61	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.59183261
62	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.58667820
63	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.58221578
64	Dopaminergic synapse_Homo sapiens_hsa04728	0.55930028
65	Peroxisome_Homo sapiens_hsa04146	0.55350257
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.54224917
67	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.52439976
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.51029217
69	Wnt signaling pathway_Homo sapiens_hsa04310	0.48073841
70	Olfactory transduction_Homo sapiens_hsa04740	0.48049594
71	Nucleotide excision repair_Homo sapiens_hsa03420	0.47939113
72	Sulfur metabolism_Homo sapiens_hsa00920	0.45016587
73	Regulation of autophagy_Homo sapiens_hsa04140	0.44545748
74	Mismatch repair_Homo sapiens_hsa03430	0.43672508
75	Cocaine addiction_Homo sapiens_hsa05030	0.43146136
76	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.42998548
77	Cholinergic synapse_Homo sapiens_hsa04725	0.41327442
78	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37705016
79	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.36571695
80	Circadian entrainment_Homo sapiens_hsa04713	0.35341512
81	Fatty acid degradation_Homo sapiens_hsa00071	0.34586158
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.34004232
83	Melanogenesis_Homo sapiens_hsa04916	0.33618299
84	Arginine and proline metabolism_Homo sapiens_hsa00330	0.33216176
85	Retinol metabolism_Homo sapiens_hsa00830	0.32400948
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.31651970
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.30374594
88	RNA transport_Homo sapiens_hsa03013	0.29429985
89	Chemical carcinogenesis_Homo sapiens_hsa05204	0.28696407
90	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.28464218
91	Taste transduction_Homo sapiens_hsa04742	0.26291206
92	Ras signaling pathway_Homo sapiens_hsa04014	0.24912552
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.23584528
94	Alcoholism_Homo sapiens_hsa05034	0.23352507
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.22885184
96	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.21370361
97	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.21097047
98	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.20511505
99	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20130532
100	Long-term depression_Homo sapiens_hsa04730	0.20001786

RPL38P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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