RPL38P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.62915193
2cytidine metabolic process (GO:0046087)7.20941050
3cytidine catabolic process (GO:0006216)7.20941050
4cytidine deamination (GO:0009972)7.20941050
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.05390978
6ribosomal small subunit assembly (GO:0000028)6.98956575
7T cell migration (GO:0072678)6.93205618
8pyrimidine ribonucleoside catabolic process (GO:0046133)6.23919347
9ribosomal small subunit biogenesis (GO:0042274)5.04451881
10regulation of B cell receptor signaling pathway (GO:0050855)4.67651150
11chaperone-mediated protein transport (GO:0072321)4.54058319
12viral transcription (GO:0019083)4.51207405
13negative regulation of execution phase of apoptosis (GO:1900118)4.41665978
14negative regulation of B cell proliferation (GO:0030889)4.36643759
15translational termination (GO:0006415)4.34043454
16nucleoside diphosphate catabolic process (GO:0009134)4.31626197
17CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.15926515
18SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.05949157
19cotranslational protein targeting to membrane (GO:0006613)4.02249997
20protein targeting to ER (GO:0045047)3.99072753
21maturation of SSU-rRNA (GO:0030490)3.96849474
22positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.94075468
23ncRNA 3-end processing (GO:0043628)3.89209090
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.81238977
25lymphocyte migration (GO:0072676)3.77486134
26protein localization to endoplasmic reticulum (GO:0070972)3.72854562
27positive regulation of alpha-beta T cell proliferation (GO:0046641)3.69558759
28translational elongation (GO:0006414)3.68619656
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.66809736
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.66809736
31NADH dehydrogenase complex assembly (GO:0010257)3.66809736
32regulation of alpha-beta T cell proliferation (GO:0046640)3.50042326
33B cell receptor signaling pathway (GO:0050853)3.46593036
34rRNA catabolic process (GO:0016075)3.41094395
35positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.39579628
36establishment of protein localization to mitochondrial membrane (GO:0090151)3.36790214
37T cell lineage commitment (GO:0002360)3.32346977
38B cell homeostasis (GO:0001782)3.30586215
39positive regulation of defense response to virus by host (GO:0002230)3.26445680
40cellular protein complex disassembly (GO:0043624)3.25369017
41myeloid dendritic cell activation (GO:0001773)3.24404089
42positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.21367984
43translational initiation (GO:0006413)3.20860170
44viral life cycle (GO:0019058)3.16971514
45deoxyribose phosphate biosynthetic process (GO:0046385)3.16809619
462-deoxyribonucleotide biosynthetic process (GO:0009265)3.16809619
47transcription from RNA polymerase I promoter (GO:0006360)3.16035658
48nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.14924414
49myeloid dendritic cell differentiation (GO:0043011)3.13962152
50translation (GO:0006412)3.13540962
51regulation of T-helper 1 cell differentiation (GO:0045625)3.12844164
52negative regulation of viral genome replication (GO:0045071)3.10355507
53protein complex biogenesis (GO:0070271)3.09457981
54activated T cell proliferation (GO:0050798)3.08813978
55positive regulation of humoral immune response (GO:0002922)3.03604749
56negative regulation of mast cell activation (GO:0033004)3.02490221
57pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99111143
58DNA demethylation (GO:0080111)2.98830464
59T cell costimulation (GO:0031295)2.96509514
60positive regulation of protein homooligomerization (GO:0032464)2.95183655
61lymphocyte costimulation (GO:0031294)2.92756741
62positive regulation of glycoprotein biosynthetic process (GO:0010560)2.87729139
63regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.85718911
64regulation of interleukin-2 biosynthetic process (GO:0045076)2.82367335
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81932811
66antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81228514
67mitochondrial respiratory chain complex assembly (GO:0033108)2.80732417
68lymphocyte chemotaxis (GO:0048247)2.80476582
69regulation of interferon-gamma biosynthetic process (GO:0045072)2.79267293
70ATP synthesis coupled proton transport (GO:0015986)2.78763051
71energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78763051
72regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.78569779
73deoxyribonucleotide biosynthetic process (GO:0009263)2.75732701
74nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.74691944
75positive regulation of protein oligomerization (GO:0032461)2.74488962
76ubiquinone biosynthetic process (GO:0006744)2.74469908
77DNA dealkylation (GO:0035510)2.73631650
78interferon-gamma production (GO:0032609)2.72401695
79positive regulation of interleukin-2 production (GO:0032743)2.71357257
80formation of translation preinitiation complex (GO:0001731)2.70361639
81protein targeting to membrane (GO:0006612)2.69517496
82antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69069402
83positive regulation of interleukin-8 secretion (GO:2000484)2.67398307
84response to interleukin-15 (GO:0070672)2.67176623
85behavioral response to nicotine (GO:0035095)2.67110051
86cellular component biogenesis (GO:0044085)2.66554744
87positive regulation of T-helper 1 type immune response (GO:0002827)2.66108701
88protein complex disassembly (GO:0043241)2.65816547
89negative regulation of B cell activation (GO:0050869)2.65693073
90pyrimidine nucleoside catabolic process (GO:0046135)2.64211187
91cellular response to interferon-beta (GO:0035458)2.64012687
92rRNA modification (GO:0000154)2.63473028
93regulation of interleukin-8 secretion (GO:2000482)2.63100863
94purine nucleoside diphosphate metabolic process (GO:0009135)2.62184357
95purine ribonucleoside diphosphate metabolic process (GO:0009179)2.62184357
96response to interferon-beta (GO:0035456)2.59885533
97protein K6-linked ubiquitination (GO:0085020)2.58551950
98ribonucleoprotein complex biogenesis (GO:0022613)2.57465205
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.56358256
100macromolecular complex disassembly (GO:0032984)2.56103872

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.41741437
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.49743953
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.28460233
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.56268755
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.06155897
6SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.89438479
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89155664
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.83356313
9SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.82340885
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80705528
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.78471133
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.73958076
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65073676
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59379670
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.57022945
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.50937722
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.48680948
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.39665022
19VDR_23849224_ChIP-Seq_CD4+_Human2.32374227
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.25753490
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20457284
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.19980253
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.15472619
24CIITA_25753668_ChIP-Seq_RAJI_Human2.11915572
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03791745
26FOXP3_21729870_ChIP-Seq_TREG_Human2.01972389
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.99396329
28FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.95459694
29BP1_19119308_ChIP-ChIP_Hs578T_Human1.86973926
30STAT4_19710469_ChIP-ChIP_TH1__Mouse1.76491790
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.72713723
32IRF1_19129219_ChIP-ChIP_H3396_Human1.72485364
33MYB_26560356_Chip-Seq_TH2_Human1.71705471
34EZH2_22144423_ChIP-Seq_EOC_Human1.68922799
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.67466099
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66106876
37EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.64502317
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63662739
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63553731
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.51287648
41MYC_22102868_ChIP-Seq_BL_Human1.49974547
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47507522
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47274371
44GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.46478506
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44384155
46PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44085244
47TTF2_22483619_ChIP-Seq_HELA_Human1.39898714
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39473205
49XRN2_22483619_ChIP-Seq_HELA_Human1.39365815
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34325197
51GATA3_26560356_Chip-Seq_TH2_Human1.33545118
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31698592
53BCL6_27268052_Chip-Seq_Bcells_Human1.30629512
54CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30482206
55EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.29642828
56SPI1_23547873_ChIP-Seq_NB4_Human1.28701673
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.27155699
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27136371
59ELK1_19687146_ChIP-ChIP_HELA_Human1.25931041
60E2F7_22180533_ChIP-Seq_HELA_Human1.25622784
61E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.25578691
62MYB_26560356_Chip-Seq_TH1_Human1.22794729
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.20385900
64THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20215664
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19812897
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18812728
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18242655
68TAF2_19829295_ChIP-Seq_ESCs_Human1.16635251
69GABP_19822575_ChIP-Seq_HepG2_Human1.16489663
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15185207
71MAF_26560356_Chip-Seq_TH2_Human1.10769365
72MAF_26560356_Chip-Seq_TH1_Human1.09825702
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09460427
74RUNX_20019798_ChIP-Seq_JUKART_Human1.08628414
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08276668
76UTX_26944678_Chip-Seq_JUKART_Human1.07945179
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07534881
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07138678
79PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.05196524
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03912253
81GATA3_27048872_Chip-Seq_THYMUS_Human1.02407398
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01012949
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99039747
84FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98223597
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96368583
86RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.96310852
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93419935
88YY1_22570637_ChIP-Seq_MALME-3M_Human0.93017053
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91866671
90MYC_18940864_ChIP-ChIP_HL60_Human0.90515417
91DCP1A_22483619_ChIP-Seq_HELA_Human0.90370732
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.89613308
93P300_27268052_Chip-Seq_Bcells_Human0.89478175
94MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.89290909
95GATA3_21867929_ChIP-Seq_TH1_Mouse0.89194822
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88978183
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87280992
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86876814
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86406457
100MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86156679

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.78533663
2MP0000685_abnormal_immune_system3.70224276
3MP0003045_fibrosis3.69849752
4MP0002163_abnormal_gland_morphology3.65757075
5MP0004145_abnormal_muscle_electrophysio3.58932896
6MP0009379_abnormal_foot_pigmentation3.52091026
7MP0001835_abnormal_antigen_presentation3.19197927
8MP0001800_abnormal_humoral_immune3.17734082
9MP0005387_immune_system_phenotype2.90154885
10MP0001790_abnormal_immune_system2.90154885
11MP0003646_muscle_fatigue2.61786301
12MP0005000_abnormal_immune_tolerance2.61740506
13MP0002723_abnormal_immune_serum2.30487271
14MP0002452_abnormal_antigen_presenting2.28154934
15MP0009785_altered_susceptibility_to2.27871808
16MP0005379_endocrine/exocrine_gland_phen2.27093674
17MP0001348_abnormal_lacrimal_gland2.23619823
18MP0002420_abnormal_adaptive_immunity2.12921366
19MP0003763_abnormal_thymus_physiology2.09625201
20MP0001819_abnormal_immune_cell2.04730332
21MP0002148_abnormal_hypersensitivity_rea2.00558336
22MP0005645_abnormal_hypothalamus_physiol1.94000471
23MP0002166_altered_tumor_susceptibility1.92374525
24MP0005025_abnormal_response_to1.91326941
25MP0002398_abnormal_bone_marrow1.90184446
26MP0009333_abnormal_splenocyte_physiolog1.84422207
27MP0003693_abnormal_embryo_hatching1.83099559
28MP0006035_abnormal_mitochondrial_morpho1.81157234
29MP0001529_abnormal_vocalization1.77290403
30MP0000716_abnormal_immune_system1.75192712
31MP0006082_CNS_inflammation1.71631392
32MP0006036_abnormal_mitochondrial_physio1.71363075
33MP0003866_abnormal_defecation1.65929885
34MP0002006_tumorigenesis1.65116558
35MP0008877_abnormal_DNA_methylation1.64388645
36MP0010094_abnormal_chromosome_stability1.47974841
37MP0000689_abnormal_spleen_morphology1.47525762
38MP0005084_abnormal_gallbladder_morpholo1.46911645
39MP0002429_abnormal_blood_cell1.44571619
40MP0002138_abnormal_hepatobiliary_system1.43019763
41MP0005310_abnormal_salivary_gland1.38844660
42MP0000703_abnormal_thymus_morphology1.38447650
43MP0002722_abnormal_immune_system1.37126553
44MP0001905_abnormal_dopamine_level1.35422402
45MP0001845_abnormal_inflammatory_respons1.30624916
46MP0002419_abnormal_innate_immunity1.27788041
47MP0001727_abnormal_embryo_implantation1.27381818
48MP0003123_paternal_imprinting1.26180611
49MP0010386_abnormal_urinary_bladder1.23662322
50MP0004142_abnormal_muscle_tone1.18438264
51MP0002168_other_aberrant_phenotype1.16905383
52MP0002933_joint_inflammation1.16708306
53MP0001919_abnormal_reproductive_system1.13266741
54MP0010155_abnormal_intestine_physiology1.10239721
55MP0008872_abnormal_physiological_respon1.10128543
56MP0005389_reproductive_system_phenotype1.06265766
57MP0005394_taste/olfaction_phenotype1.05160915
58MP0005499_abnormal_olfactory_system1.05160915
59MP0002876_abnormal_thyroid_physiology1.02618034
60MP0002405_respiratory_system_inflammati0.97658446
61MP0002095_abnormal_skin_pigmentation0.96889492
62MP0002019_abnormal_tumor_incidence0.94396073
63MP0009046_muscle_twitch0.94208997
64MP0003787_abnormal_imprinting0.93063456
65MP0002102_abnormal_ear_morphology0.91719502
66MP0003786_premature_aging0.90943034
67MP0008469_abnormal_protein_level0.87202035
68MP0004947_skin_inflammation0.83033484
69MP0002653_abnormal_ependyma_morphology0.81717160
70MP0008789_abnormal_olfactory_epithelium0.81082873
71MP0001986_abnormal_taste_sensitivity0.80454473
72MP0005623_abnormal_meninges_morphology0.79289029
73MP0000372_irregular_coat_pigmentation0.77624492
74MP0008058_abnormal_DNA_repair0.77604033
75MP0003111_abnormal_nucleus_morphology0.76352549
76MP0004957_abnormal_blastocyst_morpholog0.75202393
77MP0000358_abnormal_cell_content/0.75039340
78MP0002693_abnormal_pancreas_physiology0.74642071
79MP0002160_abnormal_reproductive_system0.72396088
80MP0003195_calcinosis0.71337797
81MP0003252_abnormal_bile_duct0.70481773
82MP0002136_abnormal_kidney_physiology0.68803494
83MP0006292_abnormal_olfactory_placode0.68602595
84MP0009745_abnormal_behavioral_response0.68201777
85MP0005253_abnormal_eye_physiology0.66634944
86MP0005386_behavior/neurological_phenoty0.65244351
87MP0004924_abnormal_behavior0.65244351
88MP0001873_stomach_inflammation0.63780720
89MP0003077_abnormal_cell_cycle0.63660138
90MP0002083_premature_death0.62630220
91MP0006276_abnormal_autonomic_nervous0.61643653
92MP0009643_abnormal_urine_homeostasis0.61606432
93MP0005464_abnormal_platelet_physiology0.60842945
94MP0005395_other_phenotype0.60457233
95MP0002210_abnormal_sex_determination0.58148947
96MP0002928_abnormal_bile_duct0.58000475
97MP0008007_abnormal_cellular_replicative0.57698069
98MP0005166_decreased_susceptibility_to0.56559389
99MP0002735_abnormal_chemical_nociception0.54534304
100MP0010307_abnormal_tumor_latency0.54341722

Predicted human phenotypes

RankGene SetZ-score
1Gastrointestinal stroma tumor (HP:0100723)4.95503458
2Abnormal delayed hypersensitivity skin test (HP:0002963)4.79425970
3Recurrent sinusitis (HP:0011108)4.49609562
4IgM deficiency (HP:0002850)4.34878432
5Recurrent bronchitis (HP:0002837)4.19820149
6Agammaglobulinemia (HP:0004432)4.16482148
7IgG deficiency (HP:0004315)4.12801688
8Recurrent gram-negative bacterial infections (HP:0005420)4.02596766
9Panhypogammaglobulinemia (HP:0003139)3.93427769
10IgA deficiency (HP:0002720)3.82486199
11Abnormality of T cell physiology (HP:0011840)3.81777952
12Acute necrotizing encephalopathy (HP:0006965)3.67198361
13Abnormality of cells of the lymphoid lineage (HP:0012140)3.50790350
14Bronchitis (HP:0012387)3.41996696
15Mitochondrial inheritance (HP:0001427)3.39112074
16Lymphopenia (HP:0001888)3.38590595
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.35680835
18Hepatocellular necrosis (HP:0001404)3.35491500
19Meningitis (HP:0001287)3.30504231
20Abnormal mitochondria in muscle tissue (HP:0008316)3.26547308
21Abnormality of T cells (HP:0002843)3.24892290
22Hepatic necrosis (HP:0002605)3.16999297
23Autoimmune hemolytic anemia (HP:0001890)3.14603316
24Progressive macrocephaly (HP:0004481)3.13779881
25Increased CSF lactate (HP:0002490)3.09067092
26Vasculitis (HP:0002633)3.05948825
27Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.02702394
28Periodontitis (HP:0000704)3.00115990
29Increased IgM level (HP:0003496)2.98358582
30Leukocytosis (HP:0001974)2.91675646
31Sparse scalp hair (HP:0002209)2.90473779
32Reticulocytopenia (HP:0001896)2.89162583
33Eosinophilia (HP:0001880)2.85984092
34Acute encephalopathy (HP:0006846)2.85854787
35Bronchiectasis (HP:0002110)2.84882364
36Recurrent abscess formation (HP:0002722)2.84005211
37Autoimmune thrombocytopenia (HP:0001973)2.79919981
38Recurrent otitis media (HP:0000403)2.79151363
39Asplenia (HP:0001746)2.78294199
40Aplasia/Hypoplasia of the spleen (HP:0010451)2.73372923
41Hypoproteinemia (HP:0003075)2.72578726
42Papilledema (HP:0001085)2.71936417
43Abnormality of T cell number (HP:0011839)2.70620853
44Increased serum lactate (HP:0002151)2.69451378
45Chronic sinusitis (HP:0011109)2.68524417
46Colon cancer (HP:0003003)2.67130133
47Lymphoma (HP:0002665)2.67017499
48Abnormality of eosinophils (HP:0001879)2.58948687
49Cerebral edema (HP:0002181)2.57161236
50Lipid accumulation in hepatocytes (HP:0006561)2.55888777
51Increased hepatocellular lipid droplets (HP:0006565)2.55667662
52Recurrent pneumonia (HP:0006532)2.41936258
53Emphysema (HP:0002097)2.40903873
54Recurrent viral infections (HP:0004429)2.39747470
55Abnormality of the prostate (HP:0008775)2.38836095
56Rhinitis (HP:0012384)2.36920195
57Abnormality of cells of the erythroid lineage (HP:0012130)2.33221583
58Granulocytopenia (HP:0001913)2.33107834
59Optic disc pallor (HP:0000543)2.29611972
60Squamous cell carcinoma (HP:0002860)2.29073634
61Chronic bronchitis (HP:0004469)2.28798947
62Increased intramyocellular lipid droplets (HP:0012240)2.26932153
63Abnormality of B cell number (HP:0010975)2.26898157
643-Methylglutaconic aciduria (HP:0003535)2.25903706
65B lymphocytopenia (HP:0010976)2.24144127
66Supernumerary spleens (HP:0009799)2.23775087
67Severe combined immunodeficiency (HP:0004430)2.22951600
68Restrictive lung disease (HP:0002091)2.19845419
69Renal Fanconi syndrome (HP:0001994)2.12316887
70Recurrent lower respiratory tract infections (HP:0002783)2.12226046
71Gingivitis (HP:0000230)2.11221069
72Abnormality of DNA repair (HP:0003254)2.10558076
73Poikiloderma (HP:0001029)2.04986505
74Elevated erythrocyte sedimentation rate (HP:0003565)2.04750217
75Thyroiditis (HP:0100646)2.03012427
76Chronic diarrhea (HP:0002028)2.02365009
77Abnormal respiratory motile cilium physiology (HP:0012261)1.98716427
78Encephalitis (HP:0002383)1.98580907
79Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98154304
80Hemiplegia (HP:0002301)1.97987404
81Leukopenia (HP:0001882)1.94988859
82Abnormality of the pulmonary veins (HP:0011718)1.94922610
83Increased muscle lipid content (HP:0009058)1.94174376
84Abnormality of the labia minora (HP:0012880)1.92841440
85Renal cortical cysts (HP:0000803)1.92754447
86Congenital stationary night blindness (HP:0007642)1.91624757
87Entropion (HP:0000621)1.89365909
88Hypoplasia of the thymus (HP:0000778)1.88118277
89Dicarboxylic aciduria (HP:0003215)1.86724727
90Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86724727
91Hyperglycinemia (HP:0002154)1.86702906
92Pallor (HP:0000980)1.86476577
93Macrocytic anemia (HP:0001972)1.85898370
94Respiratory failure (HP:0002878)1.85183938
95Neutropenia (HP:0001875)1.85049072
96Aplastic anemia (HP:0001915)1.85029679
97Anencephaly (HP:0002323)1.84807145
98Constricted visual fields (HP:0001133)1.83892520
99Recurrent fungal infections (HP:0002841)1.83601372
100Cellulitis (HP:0100658)1.82119487

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.63677840
2MAP4K13.50656798
3PRKCH3.19332007
4EIF2AK33.01149627
5TLK12.86503817
6BCKDK2.61282197
7TAOK32.50265633
8TAF12.40271844
9ZAK2.21724094
10EIF2AK12.17918663
11RIPK42.10768678
12SMG12.10368316
13CCNB12.06142343
14STK162.04451187
15VRK11.98787279
16PBK1.97879352
17TXK1.92794101
18SYK1.82612983
19MST41.79379220
20NUAK11.75095315
21DAPK11.73521881
22TYRO31.70092863
23STK241.68359718
24ITK1.63843854
25BUB11.58726485
26PRKCQ1.57462929
27CSK1.47575783
28NME21.44843380
29NEK11.41896514
30STK38L1.38979114
31NEK91.36756771
32FES1.35427035
33NME11.28494203
34CDC71.23689045
35EPHA31.21530158
36IKBKB1.19760615
37MAP3K111.17212660
38ALK1.13105374
39EIF2AK21.10989264
40KIT1.05608877
41GRK11.04301859
42DYRK20.97466319
43LCK0.95985582
44CSF1R0.92691738
45ICK0.92567733
46LRRK20.92286329
47PRKCI0.91358850
48PLK20.89352025
49MAPKAPK50.85899084
50IKBKE0.83758776
51BMPR20.83183958
52STK40.81649779
53LYN0.81040999
54PASK0.78776845
55CAMKK20.76450944
56BTK0.76282582
57JAK30.76170738
58DAPK30.76056972
59PRKCD0.75711941
60TEC0.75459723
61CSNK1G30.73142065
62AURKA0.72595793
63CSNK1A1L0.72473132
64BMPR1B0.70753527
65TNIK0.69006980
66FGFR40.68640552
67KDR0.68243473
68MAPK40.67455386
69ATR0.66925578
70FRK0.66725208
71PLK10.62886752
72GRK50.60124388
73TYK20.58044762
74TBK10.57927005
75JAK10.57288585
76PIM10.55529157
77CSNK1G20.54051893
78INSRR0.52379483
79CAMKK10.52164817
80MAP3K80.49717195
81MKNK20.46458040
82CHEK20.46058917
83CDK190.45806983
84RPS6KA50.45631585
85BLK0.45531478
86AURKB0.43266138
87PINK10.43181435
88PLK30.42901923
89ATM0.42581616
90CSNK2A20.41718680
91JAK20.40800202
92NTRK30.39978460
93ADRBK20.38531986
94PRKCB0.36196878
95MAP3K140.35493774
96OXSR10.35213061
97CSNK1A10.30978907
98PRKCG0.29587317
99CSNK1E0.29351497
100WEE10.28703174

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.38399865
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.24446808
3Allograft rejection_Homo sapiens_hsa053304.10936979
4Autoimmune thyroid disease_Homo sapiens_hsa053203.98244976
5Graft-versus-host disease_Homo sapiens_hsa053323.91067908
6Ribosome_Homo sapiens_hsa030103.38028816
7Type I diabetes mellitus_Homo sapiens_hsa049403.31957563
8RNA polymerase_Homo sapiens_hsa030203.29061686
9Viral myocarditis_Homo sapiens_hsa054162.74060367
10Asthma_Homo sapiens_hsa053102.52966795
11Proteasome_Homo sapiens_hsa030502.48009044
12Parkinsons disease_Homo sapiens_hsa050121.93566508
13Protein export_Homo sapiens_hsa030601.87492910
14Oxidative phosphorylation_Homo sapiens_hsa001901.84926875
15Antigen processing and presentation_Homo sapiens_hsa046121.80175549
16Systemic lupus erythematosus_Homo sapiens_hsa053221.69329610
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.63346245
18Rheumatoid arthritis_Homo sapiens_hsa053231.57322708
19Staphylococcus aureus infection_Homo sapiens_hsa051501.51673861
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49627835
21Pyrimidine metabolism_Homo sapiens_hsa002401.48076362
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43240251
23Homologous recombination_Homo sapiens_hsa034401.41027124
24DNA replication_Homo sapiens_hsa030301.37601386
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.36068199
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34566762
27Mismatch repair_Homo sapiens_hsa034301.33877516
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31382847
29Leishmaniasis_Homo sapiens_hsa051401.29961431
30B cell receptor signaling pathway_Homo sapiens_hsa046621.21243676
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16797545
32Nucleotide excision repair_Homo sapiens_hsa034201.14987823
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.14160965
34Huntingtons disease_Homo sapiens_hsa050161.11968031
35Epstein-Barr virus infection_Homo sapiens_hsa051691.08245974
36RNA degradation_Homo sapiens_hsa030181.06473366
37Measles_Homo sapiens_hsa051621.04410961
38Vitamin B6 metabolism_Homo sapiens_hsa007501.02573260
39Alzheimers disease_Homo sapiens_hsa050101.01380143
40Purine metabolism_Homo sapiens_hsa002300.94563182
41Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.88545092
42Herpes simplex infection_Homo sapiens_hsa051680.87634781
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83281116
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82815512
45Base excision repair_Homo sapiens_hsa034100.81793038
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.79686502
47One carbon pool by folate_Homo sapiens_hsa006700.74718260
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73828222
49Hematopoietic cell lineage_Homo sapiens_hsa046400.73775597
50Non-homologous end-joining_Homo sapiens_hsa034500.72888217
51T cell receptor signaling pathway_Homo sapiens_hsa046600.71865024
52Apoptosis_Homo sapiens_hsa042100.71357363
53Spliceosome_Homo sapiens_hsa030400.71188052
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69244124
55p53 signaling pathway_Homo sapiens_hsa041150.68105873
56Influenza A_Homo sapiens_hsa051640.65954996
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64085035
58Basal transcription factors_Homo sapiens_hsa030220.61801623
59Fanconi anemia pathway_Homo sapiens_hsa034600.60159483
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55971529
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55765302
62Legionellosis_Homo sapiens_hsa051340.53209212
63Linoleic acid metabolism_Homo sapiens_hsa005910.48735800
64Sulfur metabolism_Homo sapiens_hsa009200.47978180
65Cardiac muscle contraction_Homo sapiens_hsa042600.46772237
66Alcoholism_Homo sapiens_hsa050340.42880449
67Viral carcinogenesis_Homo sapiens_hsa052030.42322899
68HTLV-I infection_Homo sapiens_hsa051660.40961553
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38611181
70Phagosome_Homo sapiens_hsa041450.38274836
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38146942
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37938367
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.36459885
74Tuberculosis_Homo sapiens_hsa051520.34621063
75Phototransduction_Homo sapiens_hsa047440.31402382
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.30251308
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30112545
78RNA transport_Homo sapiens_hsa030130.30001221
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.29922356
80Malaria_Homo sapiens_hsa051440.29398756
81Peroxisome_Homo sapiens_hsa041460.28138695
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26500256
83Carbon metabolism_Homo sapiens_hsa012000.25499080
84Non-small cell lung cancer_Homo sapiens_hsa052230.24564191
85Chemokine signaling pathway_Homo sapiens_hsa040620.23152846
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20164276
87Propanoate metabolism_Homo sapiens_hsa006400.19204271
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.18685777
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.16871202
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.15743366
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.15003432
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14045981
93Tryptophan metabolism_Homo sapiens_hsa003800.13409442
94Osteoclast differentiation_Homo sapiens_hsa043800.12666047
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.11422256
96Metabolic pathways_Homo sapiens_hsa011000.11216090
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.10815778
98Glycerolipid metabolism_Homo sapiens_hsa005610.10232707
99Caffeine metabolism_Homo sapiens_hsa002320.09421304
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09391923

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