RPL39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the S39E family of ribosomal proteins. It is located in the cytoplasm. In rat, the protein is the smallest, and one of the most basic, proteins of the ribosome. This gene is co-transcribed with the U69 small nucleolar RNA gene, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)9.58300801
2ribosomal small subunit biogenesis (GO:0042274)9.36056608
3* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.53736394
4* translational elongation (GO:0006414)8.52142097
5* cotranslational protein targeting to membrane (GO:0006613)8.36702838
6* protein targeting to ER (GO:0045047)8.36565584
7maturation of SSU-rRNA (GO:0030490)8.13774733
8* establishment of protein localization to endoplasmic reticulum (GO:0072599)8.01583543
9* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.88005374
10* viral life cycle (GO:0019058)7.79745829
11* protein localization to endoplasmic reticulum (GO:0070972)7.79683087
12* cellular protein complex disassembly (GO:0043624)7.78642017
13* translational initiation (GO:0006413)7.31436714
14* protein complex disassembly (GO:0043241)6.75666998
15ribosomal large subunit biogenesis (GO:0042273)6.75507081
16* macromolecular complex disassembly (GO:0032984)6.27605162
17* protein targeting to membrane (GO:0006612)5.62314542
18* nuclear-transcribed mRNA catabolic process (GO:0000956)5.55528989
19* mRNA catabolic process (GO:0006402)5.27990416
20* RNA catabolic process (GO:0006401)4.87422180
21* translation (GO:0006412)4.86503734
22ribonucleoprotein complex biogenesis (GO:0022613)4.77869257
23respiratory electron transport chain (GO:0022904)4.48831183
24electron transport chain (GO:0022900)4.36263418
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.29805172
26formation of translation preinitiation complex (GO:0001731)4.21054138
27oxidative phosphorylation (GO:0006119)4.19893018
28mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.92363703
29* establishment of protein localization to membrane (GO:0090150)3.74058059
30rRNA processing (GO:0006364)3.71649945
31rRNA metabolic process (GO:0016072)3.58009624
32cellular component biogenesis (GO:0044085)3.33554975
33* establishment of protein localization to organelle (GO:0072594)3.32162390
34* protein targeting (GO:0006605)3.29831621
35ATP biosynthetic process (GO:0006754)3.26233634
36DNA deamination (GO:0045006)3.22712490
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.11764538
38purine nucleoside triphosphate biosynthetic process (GO:0009145)3.08294402
39telomere maintenance via semi-conservative replication (GO:0032201)3.07164081
40DNA strand elongation involved in DNA replication (GO:0006271)3.05447543
41chaperone-mediated protein transport (GO:0072321)3.04013666
42negative regulation of RNA splicing (GO:0033119)3.02056571
43DNA unwinding involved in DNA replication (GO:0006268)2.95837373
44regulation of translational fidelity (GO:0006450)2.94919733
45ribonucleoside triphosphate biosynthetic process (GO:0009201)2.93125115
46* cellular component disassembly (GO:0022411)2.91821007
47inner mitochondrial membrane organization (GO:0007007)2.91632047
48DNA strand elongation (GO:0022616)2.88878807
49aerobic respiration (GO:0009060)2.85009254
50* protein localization to membrane (GO:0072657)2.79749066
51protein complex biogenesis (GO:0070271)2.79310599
52interferon-gamma secretion (GO:0072643)2.78609804
53regulation of mitochondrial translation (GO:0070129)2.77322325
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.76201894
55mitochondrial respiratory chain complex assembly (GO:0033108)2.73895400
56mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.71924720
57mitochondrial respiratory chain complex I assembly (GO:0032981)2.71924720
58NADH dehydrogenase complex assembly (GO:0010257)2.71924720
59UTP biosynthetic process (GO:0006228)2.71848730
60viral protein processing (GO:0019082)2.70683576
61DNA replication initiation (GO:0006270)2.70276335
62hydrogen ion transmembrane transport (GO:1902600)2.68920269
63telomere maintenance via recombination (GO:0000722)2.67898330
64ribosome assembly (GO:0042255)2.67857849
65GTP biosynthetic process (GO:0006183)2.65945734
66ncRNA 3-end processing (GO:0043628)2.64934430
67sequestering of actin monomers (GO:0042989)2.62432045
68purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.59764139
69purine nucleoside monophosphate biosynthetic process (GO:0009127)2.59764139
70mitotic recombination (GO:0006312)2.59707567
71nucleobase-containing small molecule interconversion (GO:0015949)2.59337018
72desmosome organization (GO:0002934)2.56794422
73establishment of integrated proviral latency (GO:0075713)2.54792265
74guanosine-containing compound biosynthetic process (GO:1901070)2.52036401
75nucleoside triphosphate biosynthetic process (GO:0009142)2.51494437
76regulation of protein heterodimerization activity (GO:0043497)2.51186768
77kinetochore organization (GO:0051383)2.49454806
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.49184813
79protein localization to kinetochore (GO:0034501)2.48688790
80UTP metabolic process (GO:0046051)2.48308421
81* gene expression (GO:0010467)2.47313693
82CENP-A containing nucleosome assembly (GO:0034080)2.46765542
83viral mRNA export from host cell nucleus (GO:0046784)2.46223375
84* protein localization to organelle (GO:0033365)2.45262881
85negative regulation of ligase activity (GO:0051352)2.44159144
86negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.44159144
87telomere maintenance via telomere lengthening (GO:0010833)2.43620746
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.42683962
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.42683962
90spliceosomal complex assembly (GO:0000245)2.42351515
91spliceosomal snRNP assembly (GO:0000387)2.41034796
92protein targeting to mitochondrion (GO:0006626)2.40575690
93chromatin remodeling at centromere (GO:0031055)2.40009360
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.39879185
95pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.38874917
96proteasome assembly (GO:0043248)2.38816350
97establishment of protein localization to mitochondrion (GO:0072655)2.38622734
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.38490089
99pseudouridine synthesis (GO:0001522)2.35699447
100ncRNA processing (GO:0034470)2.32734968
101ribosome biogenesis (GO:0042254)2.30812299
102mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.30658442
103termination of RNA polymerase III transcription (GO:0006386)2.29731667
104transcription elongation from RNA polymerase III promoter (GO:0006385)2.29731667
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.27866524
106antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27803441
107antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.27803441
108histone mRNA metabolic process (GO:0008334)2.26868352
109mitotic nuclear envelope disassembly (GO:0007077)2.26691680
110regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.26611191
111ribonucleoprotein complex assembly (GO:0022618)2.25509695
112definitive hemopoiesis (GO:0060216)2.24918873
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24497704
114termination of RNA polymerase II transcription (GO:0006369)2.23802181
115folic acid-containing compound biosynthetic process (GO:0009396)2.23528661
116DNA replication-independent nucleosome assembly (GO:0006336)2.22557289
117DNA replication-independent nucleosome organization (GO:0034724)2.22557289
118positive regulation of interleukin-8 secretion (GO:2000484)2.20181284
119protein localization to chromosome, centromeric region (GO:0071459)2.18778575
120energy coupled proton transport, down electrochemical gradient (GO:0015985)2.17000768
121ATP synthesis coupled proton transport (GO:0015986)2.17000768
122kinetochore assembly (GO:0051382)2.16773762
123DNA replication checkpoint (GO:0000076)2.16380813
124DNA replication-dependent nucleosome organization (GO:0034723)2.13303174
125DNA replication-dependent nucleosome assembly (GO:0006335)2.13303174
126nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.11887360
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.09826177
128ribonucleoprotein complex subunit organization (GO:0071826)2.09765471
129membrane disassembly (GO:0030397)2.08914979
130nuclear envelope disassembly (GO:0051081)2.08914979
131negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.07937391
132mRNA splicing, via spliceosome (GO:0000398)2.07595824
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.07595824
134ncRNA metabolic process (GO:0034660)2.07510634
135RNA splicing, via transesterification reactions (GO:0000375)2.07239154
136myeloid cell homeostasis (GO:0002262)2.06572288
137nucleobase biosynthetic process (GO:0046112)2.06426801
138hemidesmosome assembly (GO:0031581)2.05536512
139DNA-templated transcription, termination (GO:0006353)2.04960608
140regulation of histone H3-K27 methylation (GO:0061085)2.04871871
141transcription-coupled nucleotide-excision repair (GO:0006283)2.02472055
142* viral transcription (GO:0019083)10.5739997
143* translational termination (GO:0006415)10.1371556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.36725524
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.99010176
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.76190598
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.99151657
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81613380
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.54144709
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.06136654
8E2F4_17652178_ChIP-ChIP_JURKAT_Human2.98886350
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.93851297
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.81486694
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.66168339
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62392475
13XRN2_22483619_ChIP-Seq_HELA_Human2.60453005
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59570663
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.53561866
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.36733766
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.30340764
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.27132484
19* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.26596279
20ELK1_19687146_ChIP-ChIP_HELA_Human2.21665044
21* TTF2_22483619_ChIP-Seq_HELA_Human2.17589241
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14586196
23VDR_23849224_ChIP-Seq_CD4+_Human2.13265127
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10500940
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05620322
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.04940825
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94321235
28CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89932635
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.86965880
30DCP1A_22483619_ChIP-Seq_HELA_Human1.85995559
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83714023
32* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.79707401
33FOXP3_21729870_ChIP-Seq_TREG_Human1.76392430
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.73440543
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70766450
36MYC_22102868_ChIP-Seq_BL_Human1.68164484
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55517987
38AR_21909140_ChIP-Seq_LNCAP_Human1.54872269
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54262982
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52777154
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.45898253
42ELK1_22589737_ChIP-Seq_MCF10A_Human1.44928449
43* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44585686
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42817065
45VDR_21846776_ChIP-Seq_THP-1_Human1.40000555
46KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39502738
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.37428214
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37086170
49BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35607933
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34460599
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.33631054
52* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33558305
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33336831
54SRF_21415370_ChIP-Seq_HL-1_Mouse1.31753577
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31548008
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31140050
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.28973727
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28919769
59GABP_19822575_ChIP-Seq_HepG2_Human1.26611482
60GATA1_22025678_ChIP-Seq_K562_Human1.25669827
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23227560
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.22751182
63SPI1_23547873_ChIP-Seq_NB4_Human1.21561514
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21231903
65ZNF263_19887448_ChIP-Seq_K562_Human1.21127969
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.19719209
67* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18712976
68TP63_19390658_ChIP-ChIP_HaCaT_Human1.18537092
69* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.17407354
70MYC_18940864_ChIP-ChIP_HL60_Human1.17028610
71STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16693789
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16339785
73FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16133456
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15471764
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12967555
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12476022
77CTCF_18555785_ChIP-Seq_MESCs_Mouse1.10771729
78CIITA_25753668_ChIP-Seq_RAJI_Human1.10649078
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10240729
80CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10201574
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09701326
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09603623
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09304520
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08533277
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.08206530
86POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06050104
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05725933
88HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.04573630
89KDM5A_27292631_Chip-Seq_BREAST_Human1.02250321
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.01805974
91KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98768648
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.97796905
93MYB_21317192_ChIP-Seq_ERMYB_Mouse0.97188138
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96895969
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96184966
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95796377
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94685881
98E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94627819
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93565658
100SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93534591
101SCL_19346495_ChIP-Seq_HPC-7_Human0.93364008
102PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93002753
103* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91943578
104MAF_26560356_Chip-Seq_TH1_Human0.91000365
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89844727
106MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.89630680
107MYB_26560356_Chip-Seq_TH2_Human0.89626677
108* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89501560
109THAP11_20581084_ChIP-Seq_MESCs_Mouse0.89469789
110HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88536077
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.86777740
112YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86727784
113OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86686703
114UTX_26944678_Chip-Seq_JUKART_Human0.86363918
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.85214307
116SOX2_16153702_ChIP-ChIP_HESCs_Human0.85047678
117SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84771544
118GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84657018
119SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84461665
120FOXP1_21924763_ChIP-Seq_HESCs_Human0.83000683
121NANOG_21062744_ChIP-ChIP_HESCs_Human0.80324390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.71977366
2MP0003693_abnormal_embryo_hatching3.13206606
3MP0004957_abnormal_blastocyst_morpholog2.79747759
4MP0000566_synostosis2.60848784
5MP0003806_abnormal_nucleotide_metabolis2.51334684
6MP0010352_gastrointestinal_tract_polyps2.34071955
7MP0008995_early_reproductive_senescence2.33620118
8MP0002396_abnormal_hematopoietic_system2.29870153
9MP0002796_impaired_skin_barrier2.24943751
10MP0010094_abnormal_chromosome_stability2.23258528
11MP0003077_abnormal_cell_cycle2.17861292
12MP0003941_abnormal_skin_development2.09637283
13MP0006292_abnormal_olfactory_placode2.06826652
14MP0008057_abnormal_DNA_replication2.03655933
15MP0003111_abnormal_nucleus_morphology1.99478158
16MP0004381_abnormal_hair_follicle1.96519760
17MP0000383_abnormal_hair_follicle1.80363973
18MP0008007_abnormal_cellular_replicative1.79520606
19MP0005501_abnormal_skin_physiology1.77524104
20MP0003186_abnormal_redox_activity1.74773382
21MP0002254_reproductive_system_inflammat1.73768723
22MP0002166_altered_tumor_susceptibility1.72800158
23MP0002009_preneoplasia1.69094030
24MP0006054_spinal_hemorrhage1.65911531
25MP0000490_abnormal_crypts_of1.65425218
26MP0002060_abnormal_skin_morphology1.64762680
27MP0003763_abnormal_thymus_physiology1.62069878
28MP0010234_abnormal_vibrissa_follicle1.58604430
29MP0001293_anophthalmia1.53615596
30MP0002006_tumorigenesis1.49879584
31MP0001216_abnormal_epidermal_layer1.49616681
32MP0000372_irregular_coat_pigmentation1.49232548
33MP0002098_abnormal_vibrissa_morphology1.48430377
34MP0008932_abnormal_embryonic_tissue1.38925354
35MP0010678_abnormal_skin_adnexa1.37935364
36MP0004808_abnormal_hematopoietic_stem1.37394546
37MP0002234_abnormal_pharynx_morphology1.37367248
38MP0001286_abnormal_eye_development1.36315679
39MP0005275_abnormal_skin_tensile1.33092003
40MP0003453_abnormal_keratinocyte_physiol1.32762625
41MP0009333_abnormal_splenocyte_physiolog1.30641629
42MP0000465_gastrointestinal_hemorrhage1.30639588
43MP0002697_abnormal_eye_size1.29848956
44MP0000685_abnormal_immune_system1.29785401
45MP0005174_abnormal_tail_pigmentation1.27736423
46MP0000350_abnormal_cell_proliferation1.27429791
47MP0001853_heart_inflammation1.27189675
48MP0003786_premature_aging1.26194222
49MP0009697_abnormal_copulation1.24704483
50MP0001545_abnormal_hematopoietic_system1.24565034
51MP0005397_hematopoietic_system_phenotyp1.24565034
52MP0002249_abnormal_larynx_morphology1.24433912
53MP0010030_abnormal_orbit_morphology1.23444439
54MP0003567_abnormal_fetal_cardiomyocyte1.23271230
55MP0008058_abnormal_DNA_repair1.23196569
56MP0005023_abnormal_wound_healing1.22761933
57MP0001835_abnormal_antigen_presentation1.22021061
58MP0000377_abnormal_hair_follicle1.21280742
59MP0003566_abnormal_cell_adhesion1.20177678
60MP0000858_altered_metastatic_potential1.19179673
61MP0002095_abnormal_skin_pigmentation1.18270154
62MP0003136_yellow_coat_color1.17880558
63MP0000049_abnormal_middle_ear1.17744272
64MP0006036_abnormal_mitochondrial_physio1.16666195
65MP0003436_decreased_susceptibility_to1.16462307
66MP0001529_abnormal_vocalization1.16229150
67MP0001800_abnormal_humoral_immune1.15349853
68MP0002398_abnormal_bone_marrow1.14989550
69MP0008789_abnormal_olfactory_epithelium1.13777427
70MP0001346_abnormal_lacrimal_gland1.12010795
71MP0002722_abnormal_immune_system1.11976438
72MP0000537_abnormal_urethra_morphology1.10936905
73MP0010771_integument_phenotype1.09566186
74MP0002019_abnormal_tumor_incidence1.07947350
75MP0002132_abnormal_respiratory_system1.07907109
76MP0000703_abnormal_thymus_morphology1.07578937
77MP0004947_skin_inflammation1.07279124
78MP0004185_abnormal_adipocyte_glucose1.04227139
79MP0001873_stomach_inflammation1.03960052
80MP0002405_respiratory_system_inflammati1.03663539
81MP0005671_abnormal_response_to1.01675731
82MP0001730_embryonic_growth_arrest0.99925995
83MP0010155_abnormal_intestine_physiology0.99815491
84MP0009053_abnormal_anal_canal0.99147619
85MP0002452_abnormal_antigen_presenting0.99072746
86MP0002420_abnormal_adaptive_immunity0.98230283
87MP0006035_abnormal_mitochondrial_morpho0.97621747
88MP0009931_abnormal_skin_appearance0.96652692
89MP0002163_abnormal_gland_morphology0.96437031
90MP0002282_abnormal_trachea_morphology0.96435324
91MP0001819_abnormal_immune_cell0.95653446
92MP0002148_abnormal_hypersensitivity_rea0.94994549
93MP0000689_abnormal_spleen_morphology0.93953124
94MP0003315_abnormal_perineum_morphology0.93032329
95MP0000762_abnormal_tongue_morphology0.92483365
96MP0002429_abnormal_blood_cell0.91245681
97MP0000647_abnormal_sebaceous_gland0.90981236
98MP0002092_abnormal_eye_morphology0.90788779
99MP0005000_abnormal_immune_tolerance0.90700856
100MP0002277_abnormal_respiratory_mucosa0.90353474
101MP0001672_abnormal_embryogenesis/_devel0.90154994
102MP0005380_embryogenesis_phenotype0.90154994
103MP0005025_abnormal_response_to0.90151105
104MP0000716_abnormal_immune_system0.89989063
105MP0002085_abnormal_embryonic_tissue0.89635147
106MP0002938_white_spotting0.89362077
107MP0005076_abnormal_cell_differentiation0.88531049
108MP0002723_abnormal_immune_serum0.88188474
109MP0001881_abnormal_mammary_gland0.88068092
110MP0003123_paternal_imprinting0.87662089
111MP0003984_embryonic_growth_retardation0.87269679
112MP0005075_abnormal_melanosome_morpholog0.87245512
113MP0005171_absent_coat_pigmentation0.86241395
114MP0003705_abnormal_hypodermis_morpholog0.85840091
115MP0009785_altered_susceptibility_to0.84205194
116MP0002111_abnormal_tail_morphology0.83190269
117MP0001697_abnormal_embryo_size0.83041665
118MP0002088_abnormal_embryonic_growth/wei0.82997788
119MP0004197_abnormal_fetal_growth/weight/0.82518514
120MP0001191_abnormal_skin_condition0.82063503
121MP0002086_abnormal_extraembryonic_tissu0.82057788
122MP0002210_abnormal_sex_determination0.81942534
123MP0010307_abnormal_tumor_latency0.81034065
124MP0001243_abnormal_dermal_layer0.80763632
125MP0000313_abnormal_cell_death0.80739802
126MP0003938_abnormal_ear_development0.80206205
127MP0000467_abnormal_esophagus_morphology0.79386787
128MP0005408_hypopigmentation0.79135279
129MP0002080_prenatal_lethality0.78890726
130MP0006072_abnormal_retinal_apoptosis0.77586609
131MP0009384_cardiac_valve_regurgitation0.77364164
132MP0000516_abnormal_urinary_system0.75937421
133MP0005367_renal/urinary_system_phenotyp0.75937421
134MP0005394_taste/olfaction_phenotype0.73473716
135MP0005499_abnormal_olfactory_system0.73473716
136MP0000631_abnormal_neuroendocrine_gland0.72533963
137MP0002822_catalepsy0.72441169
138MP0001145_abnormal_male_reproductive0.71448324
139MP0001340_abnormal_eyelid_morphology0.70343212
140MP0002084_abnormal_developmental_patter0.70172007
141MP0003937_abnormal_limbs/digits/tail_de0.68510883
142MP0001919_abnormal_reproductive_system0.67489896
143MP0002932_abnormal_joint_morphology0.66952825
144MP0003718_maternal_effect0.66467513
145MP0000750_abnormal_muscle_regeneration0.66430974
146MP0000358_abnormal_cell_content/0.66428911
147MP0002233_abnormal_nose_morphology0.65581790
148MP0002160_abnormal_reproductive_system0.64291003
149MP0000733_abnormal_muscle_development0.63809293
150MP0001727_abnormal_embryo_implantation0.59650105
151MP0008961_abnormal_basal_metabolism0.59648449
152MP0001186_pigmentation_phenotype0.58346283
153MP0003959_abnormal_lean_body0.55932860

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)9.38153745
2Reticulocytopenia (HP:0001896)8.46499929
3Abnormal number of erythroid precursors (HP:0012131)8.19421495
4Macrocytic anemia (HP:0001972)6.24069873
5Pallor (HP:0000980)5.85457974
6Abnormal hemoglobin (HP:0011902)4.77935562
7Acute necrotizing encephalopathy (HP:0006965)4.68314411
8Abnormal mitochondria in muscle tissue (HP:0008316)4.41075510
9Mitochondrial inheritance (HP:0001427)4.38547130
10Lipid accumulation in hepatocytes (HP:0006561)4.15058939
11Acute encephalopathy (HP:0006846)4.11992078
12Hepatocellular necrosis (HP:0001404)3.94460107
13Colon cancer (HP:0003003)3.81675198
14Increased CSF lactate (HP:0002490)3.65845455
15Progressive macrocephaly (HP:0004481)3.61647494
16Thrombocytosis (HP:0001894)3.49134383
17Congenital, generalized hypertrichosis (HP:0004540)3.48762371
18Renal Fanconi syndrome (HP:0001994)3.44856111
19Hepatic necrosis (HP:0002605)3.42444973
20Increased intramyocellular lipid droplets (HP:0012240)3.40498354
213-Methylglutaconic aciduria (HP:0003535)3.16940607
22Woolly hair (HP:0002224)3.13834414
23Cerebral edema (HP:0002181)3.07259907
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.07152348
25Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96813606
26Abnormality of reticulocytes (HP:0004312)2.94381208
27Stenosis of the external auditory canal (HP:0000402)2.87421647
28Increased muscle lipid content (HP:0009058)2.86643421
2911 pairs of ribs (HP:0000878)2.83617489
30Aplastic anemia (HP:0001915)2.82341274
31Depressed nasal ridge (HP:0000457)2.79328257
32Microvesicular hepatic steatosis (HP:0001414)2.77992496
33Decreased activity of mitochondrial respiratory chain (HP:0008972)2.69051574
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.69051574
35Absent thumb (HP:0009777)2.68002306
36Leukodystrophy (HP:0002415)2.58579941
37Abnormality of the parietal bone (HP:0002696)2.54588322
38Trismus (HP:0000211)2.52547040
39Exercise intolerance (HP:0003546)2.47298975
40Abnormality of the axillary hair (HP:0100134)2.45975626
41Abnormality of secondary sexual hair (HP:0009888)2.45975626
42Oral leukoplakia (HP:0002745)2.44624084
43Multiple enchondromatosis (HP:0005701)2.42807691
44Migraine (HP:0002076)2.38924298
45Selective tooth agenesis (HP:0001592)2.38090091
46Fragile nails (HP:0001808)2.37822020
47Thick lower lip vermilion (HP:0000179)2.34999029
48Lip pit (HP:0100267)2.33553164
49Duplication of thumb phalanx (HP:0009942)2.33349872
50Lactic acidosis (HP:0003128)2.28744460
51Sparse eyelashes (HP:0000653)2.28654272
52Septo-optic dysplasia (HP:0100842)2.27531997
53IgM deficiency (HP:0002850)2.24135987
54Respiratory failure (HP:0002878)2.22642162
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.21899402
56Glossoptosis (HP:0000162)2.18250645
57Increased serum lactate (HP:0002151)2.15919768
58Chromsome breakage (HP:0040012)2.13913570
59Onycholysis (HP:0001806)2.09621260
60Chronic otitis media (HP:0000389)2.08999092
61Hypotrichosis (HP:0001006)2.08709511
62Asplenia (HP:0001746)2.08456345
63Abnormality of renal resorption (HP:0011038)2.05279303
64Optic disc pallor (HP:0000543)2.04049755
65Rough bone trabeculation (HP:0100670)2.02271409
66Nasolacrimal duct obstruction (HP:0000579)1.98989408
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98936216
68Parakeratosis (HP:0001036)1.96913372
69Pancytopenia (HP:0001876)1.94620133
70Aplasia/Hypoplasia of the spleen (HP:0010451)1.92607778
71Amniotic constriction ring (HP:0009775)1.90859171
72Abnormality of placental membranes (HP:0011409)1.90859171
73Microretrognathia (HP:0000308)1.90214234
74Hypoplasia of the radius (HP:0002984)1.88660920
75Atresia of the external auditory canal (HP:0000413)1.88152006
76Missing ribs (HP:0000921)1.88047446
77Milia (HP:0001056)1.87753852
78Elevated erythrocyte sedimentation rate (HP:0003565)1.84809072
79Myelodysplasia (HP:0002863)1.84499134
80Petechiae (HP:0000967)1.83949858
81Triphalangeal thumb (HP:0001199)1.83061270
82Basal cell carcinoma (HP:0002671)1.82609452
83Erythema (HP:0010783)1.79858321
84Concave nail (HP:0001598)1.79627882
85Absent septum pellucidum (HP:0001331)1.79016813
86Pili torti (HP:0003777)1.76997947
87Partial duplication of the phalanx of hand (HP:0009999)1.74610817
88Premature graying of hair (HP:0002216)1.74557188
89Maternal diabetes (HP:0009800)1.74181751
90Breast hypoplasia (HP:0003187)1.73728069
91Poikiloderma (HP:0001029)1.73707329
92Pustule (HP:0200039)1.73486154
93Type I transferrin isoform profile (HP:0003642)1.73398560
94Aplasia cutis congenita (HP:0001057)1.73046789
95Neoplasm of the pancreas (HP:0002894)1.72518712
96Recurrent bronchitis (HP:0002837)1.72239800
97Partial duplication of thumb phalanx (HP:0009944)1.72228746
98Sparse scalp hair (HP:0002209)1.71869111
99Panhypogammaglobulinemia (HP:0003139)1.71682518
100Exertional dyspnea (HP:0002875)1.71079927
101Abnormality of the septum pellucidum (HP:0007375)1.70813487
102Blepharitis (HP:0000498)1.70094073
103Cleft eyelid (HP:0000625)1.69879049
104Increased hepatocellular lipid droplets (HP:0006565)1.69829071
105Proximal placement of thumb (HP:0009623)1.68682930
106Plantar hyperkeratosis (HP:0007556)1.67622990
107Abnormality of the lacrimal duct (HP:0011481)1.67087413
108Short middle phalanx of the 5th finger (HP:0004220)1.64888134
109Rectal prolapse (HP:0002035)1.63117903
110Squamous cell carcinoma (HP:0002860)1.63082546
111Premature ovarian failure (HP:0008209)1.62242740
112Nail dystrophy (HP:0008404)1.61920739
113Birth length less than 3rd percentile (HP:0003561)1.61456482
114Lymphoma (HP:0002665)1.60844783
115Abnormality of the preputium (HP:0100587)1.59244841
116Entropion (HP:0000621)1.59119999
117Respiratory difficulties (HP:0002880)1.59115422
118Septate vagina (HP:0001153)1.58292410
119Hyperphosphaturia (HP:0003109)1.58139317
120Deviation of the thumb (HP:0009603)1.57527290
121Facial cleft (HP:0002006)1.57056567
122Meckel diverticulum (HP:0002245)1.56499181
123Megaloblastic anemia (HP:0001889)1.56233693
124Aplasia/Hypoplasia of the thymus (HP:0010515)1.54125160
125Abnormal blistering of the skin (HP:0008066)1.54124942
126Mesangial abnormality (HP:0001966)1.53898268
127Spastic paraparesis (HP:0002313)1.52452637
128Rib fusion (HP:0000902)1.51635378
129Hypoproteinemia (HP:0003075)1.51090891
130Seborrheic dermatitis (HP:0001051)1.50910379
131Broad distal phalanx of finger (HP:0009836)1.50813525
132Agnosia (HP:0010524)1.50305903
133Ridged nail (HP:0001807)1.49960398
134Degeneration of anterior horn cells (HP:0002398)1.49182031
135Abnormality of the anterior horn cell (HP:0006802)1.49182031
136Skin ulcer (HP:0200042)1.48817743
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.48466037
138Abnormality of the ileum (HP:0001549)1.48325362
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.47685262
140Osteolytic defects of the hand bones (HP:0009699)1.47685262
141Bicuspid aortic valve (HP:0001647)1.47497352
142Delayed cranial suture closure (HP:0000270)1.47383288
143Amaurosis fugax (HP:0100576)1.45836047
144Abnormal trabecular bone morphology (HP:0100671)1.45755316
145Abnormal umbilical cord blood vessels (HP:0011403)1.45737873
146Single umbilical artery (HP:0001195)1.45737873
147Abnormality of the fetal cardiovascular system (HP:0010948)1.45737873
148Bilateral microphthalmos (HP:0007633)1.45620349
149Emotional lability (HP:0000712)1.44581603
150Viral hepatitis (HP:0006562)1.44220431
151Abnormality of cochlea (HP:0000375)1.44215658
152Progressive muscle weakness (HP:0003323)1.43934809
153Morphological abnormality of the inner ear (HP:0011390)1.43715723
154Abnormality of the nasolacrimal system (HP:0000614)1.43413570
155Abnormal number of incisors (HP:0011064)1.42874506
156Abnormality of the umbilical cord (HP:0010881)1.42567473
157Abnormality of T cell physiology (HP:0011840)1.42411313
158Anhidrosis (HP:0000970)1.42406238
159Short nose (HP:0003196)1.41071967
160Cellular immunodeficiency (HP:0005374)1.41023451
161Villous atrophy (HP:0011473)1.39847901
162Abnormality of small intestinal villus morphology (HP:0011472)1.39847901

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.62386350
2NME24.90639360
3RPS6KB23.07536671
4LRRK22.92111642
5WEE12.83632845
6EEF2K2.77039376
7MST42.44779232
8TAF12.30389413
9BUB12.20271411
10PIM22.19296754
11SMG12.18658407
12TLK12.16315594
13MAP3K122.10261545
14TGFBR12.09030294
15CDC71.99179783
16VRK11.94232620
17DYRK31.92698851
18STK101.90438178
19MAPKAPK31.89069591
20NME11.79977646
21SRPK11.78876273
22PASK1.76383511
23RPS6KA41.70611870
24EIF2AK11.67859912
25MAP4K11.58718450
26AURKB1.54005125
27NEK21.48571498
28MAP3K101.40001815
29FLT31.39546832
30BRSK21.38399578
31MST1R1.36313750
32MKNK11.35469286
33ACVR1B1.32047498
34EIF2AK31.30653804
35CDK71.30296432
36MAP3K31.28104297
37PRPF4B1.27236472
38ILK1.26398743
39DAPK31.23985140
40TEC1.17284480
41CDK61.15899562
42PIM11.14755630
43BTK1.13577086
44MAPK151.11147764
45CDK191.09191493
46PNCK1.08270130
47KDR1.04889270
48PKN21.04861613
49EPHA21.02795775
50TYK21.01764639
51TRIB31.01748969
52PAK40.97123870
53CDK40.96126445
54IKBKB0.94110434
55MAP3K80.93501238
56TRPM70.93423827
57PLK10.91645192
58BLK0.91183810
59STK160.87595521
60ATR0.87125999
61IRAK30.86587503
62TTK0.86137896
63EIF2AK20.84882509
64PBK0.84463956
65STK240.81968215
66KIT0.81284756
67NLK0.81074282
68SCYL20.78687103
69DYRK20.78515104
70ARAF0.78095868
71TGFBR20.77384446
72STK40.76052240
73GRK60.75390737
74PAK20.74484391
75CDK30.71506418
76MAP2K30.70720193
77RPS6KA50.69013897
78CSNK2A20.68883756
79CSF1R0.67177876
80TSSK60.65704845
81ITK0.64507257
82BRAF0.64325915
83AURKA0.62951000
84DYRK1B0.62720676
85PLK40.62398507
86BMPR20.61233614
87CCNB10.61145270
88TESK20.59429478
89JAK30.59225835
90CDK80.57653622
91ZAP700.56792634
92STK30.56535909
93ERN10.55631103
94CSNK2A10.55157603
95EPHB20.54892061
96PIK3CG0.54203672
97CHEK10.52608534
98TAOK20.51419181
99RPS6KL10.51314747
100RPS6KC10.51314747
101PLK30.50579926
102SYK0.49809859
103MAPKAPK20.49750094
104BRSK10.49286442
105LCK0.49243979
106CHEK20.48233816
107RPS6KA60.47365566
108ZAK0.46688873
109MKNK20.46190307
110IRAK40.45757477
111ATM0.43770426
112NUAK10.43751275
113LYN0.41943329
114TESK10.41118786
115CLK10.40352144
116BCKDK0.39465941
117PAK10.39171384
118ABL20.38819697
119TBK10.38382285
120MAP2K20.37673254
121CDK11A0.36840469
122MATK0.36783867
123CDK120.36257106
124NEK10.36027953
125MAPKAPK50.35912211
126TXK0.34595106
127CDK20.33672649
128IRAK20.33293195
129SIK10.33166399
130CDK10.32050974
131CDK90.28085841
132TYRO30.27192516
133MELK0.26480199
134DAPK10.25370504
135PTK60.25059955

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030108.24321750
2DNA replication_Homo sapiens_hsa030303.53705909
3Mismatch repair_Homo sapiens_hsa034302.93153086
4Spliceosome_Homo sapiens_hsa030402.74504822
5RNA polymerase_Homo sapiens_hsa030202.71160801
6Proteasome_Homo sapiens_hsa030502.50774441
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.48710531
8Homologous recombination_Homo sapiens_hsa034402.07957958
9RNA transport_Homo sapiens_hsa030132.06025750
10Nucleotide excision repair_Homo sapiens_hsa034202.05665977
11Pyrimidine metabolism_Homo sapiens_hsa002401.90835046
12Base excision repair_Homo sapiens_hsa034101.88465756
13Cardiac muscle contraction_Homo sapiens_hsa042601.82531355
14p53 signaling pathway_Homo sapiens_hsa041151.66505267
15Cell cycle_Homo sapiens_hsa041101.63860304
16One carbon pool by folate_Homo sapiens_hsa006701.60452177
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57846815
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.53601404
19Non-homologous end-joining_Homo sapiens_hsa034501.53564089
20RNA degradation_Homo sapiens_hsa030181.45059248
21Systemic lupus erythematosus_Homo sapiens_hsa053221.40058759
22Fanconi anemia pathway_Homo sapiens_hsa034601.37693709
23Primary immunodeficiency_Homo sapiens_hsa053401.34464091
24Protein export_Homo sapiens_hsa030601.28058688
25Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.23493271
26Antigen processing and presentation_Homo sapiens_hsa046121.13526551
27Herpes simplex infection_Homo sapiens_hsa051681.08102367
28Hematopoietic cell lineage_Homo sapiens_hsa046401.02095675
29Epstein-Barr virus infection_Homo sapiens_hsa051691.00082030
30Small cell lung cancer_Homo sapiens_hsa052221.00004347
31Basal transcription factors_Homo sapiens_hsa030220.99825082
32Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.97780752
33Parkinsons disease_Homo sapiens_hsa050120.93766339
34Oxidative phosphorylation_Homo sapiens_hsa001900.89543225
35Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89001615
36Viral carcinogenesis_Homo sapiens_hsa052030.87815981
37HTLV-I infection_Homo sapiens_hsa051660.83113450
38mRNA surveillance pathway_Homo sapiens_hsa030150.82695612
39Huntingtons disease_Homo sapiens_hsa050160.78966583
40Basal cell carcinoma_Homo sapiens_hsa052170.77736661
41Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.77339463
42NF-kappa B signaling pathway_Homo sapiens_hsa040640.77188777
43Purine metabolism_Homo sapiens_hsa002300.76804945
44Thyroid cancer_Homo sapiens_hsa052160.75975098
45Legionellosis_Homo sapiens_hsa051340.74188668
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74025538
47MicroRNAs in cancer_Homo sapiens_hsa052060.73875530
48Measles_Homo sapiens_hsa051620.70398999
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.65960857
50Folate biosynthesis_Homo sapiens_hsa007900.64715076
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63333718
52Apoptosis_Homo sapiens_hsa042100.63186601
53Biosynthesis of amino acids_Homo sapiens_hsa012300.61883650
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61626944
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.61411528
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.60789704
57Glutathione metabolism_Homo sapiens_hsa004800.60532865
58Leishmaniasis_Homo sapiens_hsa051400.59362068
59TGF-beta signaling pathway_Homo sapiens_hsa043500.59115067
60Asthma_Homo sapiens_hsa053100.56824422
61Bladder cancer_Homo sapiens_hsa052190.56177371
62Hepatitis B_Homo sapiens_hsa051610.55650558
63Leukocyte transendothelial migration_Homo sapiens_hsa046700.53881042
64Sulfur relay system_Homo sapiens_hsa041220.53020993
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52283023
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52273888
67ECM-receptor interaction_Homo sapiens_hsa045120.51438388
68Toxoplasmosis_Homo sapiens_hsa051450.50497550
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.50302424
70Allograft rejection_Homo sapiens_hsa053300.49270600
71Alzheimers disease_Homo sapiens_hsa050100.49250563
72Carbon metabolism_Homo sapiens_hsa012000.48929091
73Arachidonic acid metabolism_Homo sapiens_hsa005900.47296493
74Pathways in cancer_Homo sapiens_hsa052000.47210156
75Pyruvate metabolism_Homo sapiens_hsa006200.46631755
76B cell receptor signaling pathway_Homo sapiens_hsa046620.46424782
77Type I diabetes mellitus_Homo sapiens_hsa049400.46088798
78Metabolic pathways_Homo sapiens_hsa011000.45961604
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.42712455
80Chronic myeloid leukemia_Homo sapiens_hsa052200.41774805
81Autoimmune thyroid disease_Homo sapiens_hsa053200.41024697
82Proteoglycans in cancer_Homo sapiens_hsa052050.41009734
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40991752
84Hippo signaling pathway_Homo sapiens_hsa043900.40674194
85Adherens junction_Homo sapiens_hsa045200.40324878
86Shigellosis_Homo sapiens_hsa051310.40037702
87Acute myeloid leukemia_Homo sapiens_hsa052210.39900506
88Notch signaling pathway_Homo sapiens_hsa043300.39594430
89T cell receptor signaling pathway_Homo sapiens_hsa046600.39038499
90N-Glycan biosynthesis_Homo sapiens_hsa005100.38191795
91Renin-angiotensin system_Homo sapiens_hsa046140.37890385
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37869316
93Viral myocarditis_Homo sapiens_hsa054160.37548932
94Graft-versus-host disease_Homo sapiens_hsa053320.37234696
95Colorectal cancer_Homo sapiens_hsa052100.37217034
96Influenza A_Homo sapiens_hsa051640.36820500
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.36582758
98Alcoholism_Homo sapiens_hsa050340.36500298
99Pentose phosphate pathway_Homo sapiens_hsa000300.35695100
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35633803
101Malaria_Homo sapiens_hsa051440.35270535
102Platelet activation_Homo sapiens_hsa046110.34339672
103Caffeine metabolism_Homo sapiens_hsa002320.34224325
104AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32101089
105Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.30764109
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30715841
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29312362
108Pertussis_Homo sapiens_hsa051330.29152064
109Prostate cancer_Homo sapiens_hsa052150.28772146
110Osteoclast differentiation_Homo sapiens_hsa043800.28501402
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28375739
112Hedgehog signaling pathway_Homo sapiens_hsa043400.28342282
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26747085
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22642636
115Vitamin digestion and absorption_Homo sapiens_hsa049770.19359061
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19171190
117Tyrosine metabolism_Homo sapiens_hsa003500.16785776
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.12459256
119Galactose metabolism_Homo sapiens_hsa000520.11141062
120Wnt signaling pathway_Homo sapiens_hsa043100.10502650
121Fructose and mannose metabolism_Homo sapiens_hsa000510.08535136
122Fatty acid elongation_Homo sapiens_hsa000620.08371084
123Non-small cell lung cancer_Homo sapiens_hsa052230.07365657
124Rheumatoid arthritis_Homo sapiens_hsa053230.07339770
125Fat digestion and absorption_Homo sapiens_hsa049750.06485332
126Pancreatic cancer_Homo sapiens_hsa052120.05898305
127Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.05825856
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.05309210
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.04256208
130HIF-1 signaling pathway_Homo sapiens_hsa040660.03646700
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.03385644
132Chemical carcinogenesis_Homo sapiens_hsa052040.03042029

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