RPL39L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein sharing high sequence similarity with ribosomal protein L39. Although the name of this gene has been referred to as 'ribosomal protein L39' in the public databases, its official name is 'ribosomal protein L39-like'. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.33990948
2piRNA metabolic process (GO:0034587)5.80142959
3synaptonemal complex assembly (GO:0007130)5.65510696
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.40720324
5ATP synthesis coupled proton transport (GO:0015986)5.40720324
6synaptonemal complex organization (GO:0070193)5.35791583
7chaperone-mediated protein transport (GO:0072321)5.31011686
8establishment of integrated proviral latency (GO:0075713)5.09894230
9ribosomal small subunit assembly (GO:0000028)4.66943106
10mitotic metaphase plate congression (GO:0007080)4.54935622
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.52798318
12DNA deamination (GO:0045006)4.44984225
13viral transcription (GO:0019083)4.40685566
14male meiosis (GO:0007140)4.38769504
15translational termination (GO:0006415)4.36630242
16respiratory electron transport chain (GO:0022904)4.30460571
17fusion of sperm to egg plasma membrane (GO:0007342)4.27647919
18DNA methylation involved in gamete generation (GO:0043046)4.26496170
19ribosome assembly (GO:0042255)4.24506458
20purine nucleobase biosynthetic process (GO:0009113)4.23713367
21electron transport chain (GO:0022900)4.19685975
22regulation of mitotic spindle checkpoint (GO:1903504)4.17355871
23regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.17355871
24chromosome organization involved in meiosis (GO:0070192)4.13646121
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.06552264
26male meiosis I (GO:0007141)4.06377511
27ribosome biogenesis (GO:0042254)4.03381327
28sperm-egg recognition (GO:0035036)4.02832279
29cotranslational protein targeting to membrane (GO:0006613)4.02178402
30binding of sperm to zona pellucida (GO:0007339)4.01078437
31meiosis I (GO:0007127)4.00613490
32meiotic nuclear division (GO:0007126)3.98483360
33establishment of viral latency (GO:0019043)3.96872404
34protein targeting to ER (GO:0045047)3.96829362
35DNA replication checkpoint (GO:0000076)3.95626897
36negative regulation of ligase activity (GO:0051352)3.92846292
37negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.92846292
38nucleobase biosynthetic process (GO:0046112)3.91987156
39protein neddylation (GO:0045116)3.91265115
40exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.88227099
41protein K6-linked ubiquitination (GO:0085020)3.84624753
42nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.82856732
43spermatid development (GO:0007286)3.81690360
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80844772
45sperm motility (GO:0030317)3.79467644
46microtubule depolymerization (GO:0007019)3.78586334
47regulation of mitochondrial translation (GO:0070129)3.77776767
48protein localization to chromosome, centromeric region (GO:0071459)3.76625307
49rRNA modification (GO:0000154)3.74907043
50translational elongation (GO:0006414)3.72213871
51protein localization to endoplasmic reticulum (GO:0070972)3.71822572
52regulation of helicase activity (GO:0051095)3.70864250
53formation of translation preinitiation complex (GO:0001731)3.70504033
54histone exchange (GO:0043486)3.70467846
55translational initiation (GO:0006413)3.69365903
56* translation (GO:0006412)3.66990116
57metaphase plate congression (GO:0051310)3.66064719
58DNA strand elongation involved in DNA replication (GO:0006271)3.64359269
59ribonucleoprotein complex biogenesis (GO:0022613)3.63637828
60protein complex biogenesis (GO:0070271)3.61722365
61kinetochore assembly (GO:0051382)3.61376026
62mitochondrial respiratory chain complex assembly (GO:0033108)3.60810552
63DNA replication-dependent nucleosome organization (GO:0034723)3.58984230
64DNA replication-dependent nucleosome assembly (GO:0006335)3.58984230
65chromatin remodeling at centromere (GO:0031055)3.58716268
66proteasome assembly (GO:0043248)3.58223561
67regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.57591107
68cell-cell recognition (GO:0009988)3.57095878
69maturation of SSU-rRNA (GO:0030490)3.56567576
70nuclear pore organization (GO:0006999)3.55548167
71telomere maintenance via semi-conservative replication (GO:0032201)3.54277505
72regulation of spindle organization (GO:0090224)3.52742054
73kinetochore organization (GO:0051383)3.51963888
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47908869
75DNA strand elongation (GO:0022616)3.46200027
76chaperone-mediated protein complex assembly (GO:0051131)3.45161015
77folic acid metabolic process (GO:0046655)3.44612473
78pseudouridine synthesis (GO:0001522)3.44323841
79regulation of posttranscriptional gene silencing (GO:0060147)3.44320558
80regulation of gene silencing by miRNA (GO:0060964)3.44320558
81regulation of gene silencing by RNA (GO:0060966)3.44320558
82acrosome assembly (GO:0001675)3.43554631
83CENP-A containing nucleosome assembly (GO:0034080)3.42682316
84meiotic cell cycle process (GO:1903046)3.41396292
85protein localization to kinetochore (GO:0034501)3.39675716
86IMP biosynthetic process (GO:0006188)3.38904068
87DNA damage response, detection of DNA damage (GO:0042769)3.37932054
88transcription elongation from RNA polymerase III promoter (GO:0006385)3.37681782
89termination of RNA polymerase III transcription (GO:0006386)3.37681782
90ribosomal large subunit biogenesis (GO:0042273)3.36972319
91mitotic nuclear envelope disassembly (GO:0007077)3.35183625
92termination of RNA polymerase I transcription (GO:0006363)3.34922732
93protein targeting to mitochondrion (GO:0006626)3.33927928
94nuclear pore complex assembly (GO:0051292)3.33836176
95spliceosomal snRNP assembly (GO:0000387)3.32116781
96cilium or flagellum-dependent cell motility (GO:0001539)3.31946019
97regulation of cellular amino acid metabolic process (GO:0006521)3.31398857
98axonemal dynein complex assembly (GO:0070286)3.31176880
99mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.31063434
100mitochondrial respiratory chain complex I assembly (GO:0032981)3.31063434
101NADH dehydrogenase complex assembly (GO:0010257)3.31063434
102regulation of chromosome segregation (GO:0051983)3.30301602
103cellular protein complex disassembly (GO:0043624)3.29585597
104transcription from RNA polymerase I promoter (GO:0006360)3.29418090
105anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.27476659
106viral life cycle (GO:0019058)3.27021946
107blastocyst development (GO:0001824)3.26458523
108cell wall macromolecule catabolic process (GO:0016998)3.26408293
109cell wall macromolecule metabolic process (GO:0044036)3.26408293
110respiratory chain complex IV assembly (GO:0008535)3.25222364
111rRNA processing (GO:0006364)3.24942700
112transcription elongation from RNA polymerase I promoter (GO:0006362)3.22993303
113regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.22816889
114L-serine metabolic process (GO:0006563)3.20748035
115regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.20702203
116attachment of spindle microtubules to kinetochore (GO:0008608)3.20471970
117DNA replication-independent nucleosome assembly (GO:0006336)3.20037635
118DNA replication-independent nucleosome organization (GO:0034724)3.20037635
119DNA replication initiation (GO:0006270)3.19958141
120regulation of nuclear cell cycle DNA replication (GO:0033262)3.19849428
121multicellular organism reproduction (GO:0032504)3.19366579
122signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.18985788
123signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.18985788
124signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.18985788
125negative regulation of chromosome segregation (GO:0051985)3.18727374
1267-methylguanosine mRNA capping (GO:0006370)3.17986075
127DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17767632
128rRNA metabolic process (GO:0016072)3.16985029
129mitotic sister chromatid segregation (GO:0000070)3.16165588
130ribosomal small subunit biogenesis (GO:0042274)3.15027392
131spindle checkpoint (GO:0031577)3.14135463
132signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.13998707
133intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.13998707
134positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.13560387
135negative regulation of mitotic sister chromatid separation (GO:2000816)3.12605576
136negative regulation of mitotic sister chromatid segregation (GO:0033048)3.12605576
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.12605576
138negative regulation of sister chromatid segregation (GO:0033046)3.12605576
139cellular component biogenesis (GO:0044085)3.12115847
140nuclear envelope disassembly (GO:0051081)3.11992458
141membrane disassembly (GO:0030397)3.11992458
142regulation of meiosis I (GO:0060631)3.11913480
143negative regulation of DNA-dependent DNA replication (GO:2000104)3.11668776
144establishment of protein localization to mitochondrion (GO:0072655)3.11354234
145oxidative phosphorylation (GO:0006119)3.11105461
146establishment of protein localization to mitochondrial membrane (GO:0090151)3.10685323
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.09753174
148tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.09753174
149rRNA methylation (GO:0031167)3.09739189
150positive regulation of chromosome segregation (GO:0051984)3.09656881
151cytochrome complex assembly (GO:0017004)3.09110006
152signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08954322
153signal transduction involved in DNA damage checkpoint (GO:0072422)3.08954322
1547-methylguanosine RNA capping (GO:0009452)3.08718449
155RNA capping (GO:0036260)3.08718449
156negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.08551707
157regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06898023
158establishment of chromosome localization (GO:0051303)3.06140505
159plasma membrane fusion (GO:0045026)3.05211161
160negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.04630698
161mitotic spindle checkpoint (GO:0071174)3.04308343
162regulation of cilium movement (GO:0003352)3.03560237
163reciprocal meiotic recombination (GO:0007131)3.02638068
164reciprocal DNA recombination (GO:0035825)3.02638068
165positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01713252
166regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00865334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.54601448
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.48226662
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.01978073
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.88228091
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.63169956
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.10801166
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09630386
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.05415039
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03557368
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.97388662
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90154860
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.87909019
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.87526150
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84538132
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.78723540
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73063241
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.63663605
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31513309
19CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.21750396
20AR_21909140_ChIP-Seq_LNCAP_Human2.20061986
21XRN2_22483619_ChIP-Seq_HELA_Human2.10222305
22* VDR_23849224_ChIP-Seq_CD4+_Human2.09961313
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.07645214
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06874265
25NANOG_18555785_ChIP-Seq_MESCs_Mouse2.06114510
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03947721
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.94993586
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92590745
29DCP1A_22483619_ChIP-Seq_HELA_Human1.85451462
30SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85131661
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.84236025
32TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81858628
33GABP_19822575_ChIP-Seq_HepG2_Human1.79447474
34MYC_18940864_ChIP-ChIP_HL60_Human1.78886491
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78356915
36YY1_21170310_ChIP-Seq_MESCs_Mouse1.77801348
37KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75595608
38KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75595608
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75595608
40NANOG_16153702_ChIP-ChIP_HESCs_Human1.72124116
41HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70466504
42KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68959949
43POU5F1_16153702_ChIP-ChIP_HESCs_Human1.67690865
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.66952914
45FOXP3_21729870_ChIP-Seq_TREG_Human1.66143960
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60360638
47NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.60246579
48SOX2_16153702_ChIP-ChIP_HESCs_Human1.57983372
49TTF2_22483619_ChIP-Seq_HELA_Human1.57233143
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57210673
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53785227
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53511138
53PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50635277
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.49585335
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46873910
56POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46094095
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.45220066
58KDM5A_27292631_Chip-Seq_BREAST_Human1.41240665
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.41129693
60NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35316751
61ZNF263_19887448_ChIP-Seq_K562_Human1.33856584
62ELK1_19687146_ChIP-ChIP_HELA_Human1.30625620
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28936212
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28811125
65EWS_26573619_Chip-Seq_HEK293_Human1.27053709
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25735030
67HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24201233
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.21476080
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18105218
70ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17366282
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17182755
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.16356427
73KAP1_22055183_ChIP-Seq_ESCs_Mouse1.16188476
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13782752
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.13677909
76VDR_22108803_ChIP-Seq_LS180_Human1.13442563
77DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.11618456
78* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11573919
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.10593081
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.07061124
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05748221
82FLI1_27457419_Chip-Seq_LIVER_Mouse1.05616563
83NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.04835417
84FUS_26573619_Chip-Seq_HEK293_Human1.04265813
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03347806
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02081836
87ELK1_22589737_ChIP-Seq_MCF10A_Human0.99538571
88NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97908877
89CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97003796
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96826402
91ZNF274_21170338_ChIP-Seq_K562_Hela0.96730228
92SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96454889
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.96414045
94POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94308019
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92568182
96KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92527516
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.91675339
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.91498508
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90487353
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90250782
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88534782
102TCF3_18692474_ChIP-Seq_MESCs_Mouse0.88269539
103KAP1_27257070_Chip-Seq_ESCs_Mouse0.87063136
104NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.85415985
105TP63_19390658_ChIP-ChIP_HaCaT_Human0.85392928
106PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.85362359
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.84785839
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.84590507
109SOX2_18692474_ChIP-Seq_MESCs_Mouse0.84246192
110SOX17_20123909_ChIP-Seq_XEN_Mouse0.83587544
111IRF1_19129219_ChIP-ChIP_H3396_Human0.82615977
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81812128
113ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81295753
114ERG_20887958_ChIP-Seq_HPC-7_Mouse0.79654222
115TFEB_21752829_ChIP-Seq_HELA_Human0.78895302
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.78571056
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77604044
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.77357143
119NANOG_18692474_ChIP-Seq_MESCs_Mouse0.77349401
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.77240617
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.73292565
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.72144112
123PCGF2_27294783_Chip-Seq_ESCs_Mouse0.71188185
124CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.69997696
125FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69168164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51002140
2MP0005410_abnormal_fertilization4.92383706
3MP0003111_abnormal_nucleus_morphology4.50467013
4MP0008877_abnormal_DNA_methylation4.33986862
5MP0004957_abnormal_blastocyst_morpholog4.27245701
6MP0002254_reproductive_system_inflammat3.92925987
7MP0010094_abnormal_chromosome_stability3.73726710
8MP0003077_abnormal_cell_cycle3.43296298
9MP0008057_abnormal_DNA_replication3.38878449
10MP0009379_abnormal_foot_pigmentation3.28593844
11MP0003718_maternal_effect3.15773210
12MP0001929_abnormal_gametogenesis3.15435458
13MP0008058_abnormal_DNA_repair3.14319240
14MP0002210_abnormal_sex_determination2.91300983
15MP0003786_premature_aging2.79954926
16MP0003698_abnormal_male_reproductive2.70696048
17MP0008932_abnormal_embryonic_tissue2.62921895
18MP0001145_abnormal_male_reproductive2.49624658
19MP0008007_abnormal_cellular_replicative2.40433793
20MP0001730_embryonic_growth_arrest2.25945378
21MP0000653_abnormal_sex_gland2.19222156
22MP0003123_paternal_imprinting2.05391458
23MP0002938_white_spotting1.98439565
24MP0009697_abnormal_copulation1.98329240
25MP0002653_abnormal_ependyma_morphology1.94156778
26MP0000350_abnormal_cell_proliferation1.88864540
27MP0006072_abnormal_retinal_apoptosis1.83796998
28MP0001188_hyperpigmentation1.79410964
29MP0002161_abnormal_fertility/fecundity1.71660124
30MP0005380_embryogenesis_phenotype1.71386113
31MP0001672_abnormal_embryogenesis/_devel1.71386113
32MP0003941_abnormal_skin_development1.68638082
33MP0002160_abnormal_reproductive_system1.55446959
34MP0001697_abnormal_embryo_size1.54702195
35MP0010307_abnormal_tumor_latency1.52422974
36MP0006036_abnormal_mitochondrial_physio1.52209931
37MP0002085_abnormal_embryonic_tissue1.47838096
38MP0008995_early_reproductive_senescence1.45172894
39MP0003806_abnormal_nucleotide_metabolis1.44347348
40MP0003984_embryonic_growth_retardation1.43835169
41MP0005395_other_phenotype1.41858888
42MP0002080_prenatal_lethality1.41650648
43MP0002088_abnormal_embryonic_growth/wei1.40271003
44MP0008260_abnormal_autophagy1.39216097
45MP0002736_abnormal_nociception_after1.37263779
46MP0002084_abnormal_developmental_patter1.30959502
47MP0010352_gastrointestinal_tract_polyps1.30536690
48MP0005389_reproductive_system_phenotype1.30128938
49MP0003315_abnormal_perineum_morphology1.26047959
50MP0001529_abnormal_vocalization1.25139461
51MP0002086_abnormal_extraembryonic_tissu1.21443649
52MP0000313_abnormal_cell_death1.20382273
53MP0004197_abnormal_fetal_growth/weight/1.18746274
54MP0001286_abnormal_eye_development1.13185578
55MP0003136_yellow_coat_color1.13119796
56MP0001542_abnormal_bone_strength1.12830635
57MP0000049_abnormal_middle_ear1.11300949
58MP0000358_abnormal_cell_content/1.10718594
59MP0005377_hearing/vestibular/ear_phenot1.09531136
60MP0003878_abnormal_ear_physiology1.09531136
61MP0002697_abnormal_eye_size1.09205152
62MP0001119_abnormal_female_reproductive1.09069508
63MP0001485_abnormal_pinna_reflex1.06420337
64MP0003646_muscle_fatigue1.02122880
65MP0001293_anophthalmia1.02062762
66MP0002277_abnormal_respiratory_mucosa1.00361830
67MP0005670_abnormal_white_adipose1.00172634
68MP0008789_abnormal_olfactory_epithelium0.97029303
69MP0003121_genomic_imprinting0.94919351
70MP0003699_abnormal_female_reproductive0.94300938
71MP0000579_abnormal_nail_morphology0.93431006
72MP0000750_abnormal_muscle_regeneration0.92631921
73MP0003567_abnormal_fetal_cardiomyocyte0.90962574
74MP0002796_impaired_skin_barrier0.90527750
75MP0005076_abnormal_cell_differentiation0.89948160
76MP0008872_abnormal_physiological_respon0.88445847
77MP0003119_abnormal_digestive_system0.88404084
78MP0002019_abnormal_tumor_incidence0.88275041
79MP0001661_extended_life_span0.87868960
80MP0010030_abnormal_orbit_morphology0.85979831
81MP0002090_abnormal_vision0.85629180
82MP0000372_irregular_coat_pigmentation0.85305095
83MP0001984_abnormal_olfaction0.84124371
84MP0003011_delayed_dark_adaptation0.83238091
85MP0002638_abnormal_pupillary_reflex0.81666885
86MP0003936_abnormal_reproductive_system0.81588842
87MP0001727_abnormal_embryo_implantation0.81184975
88MP0003937_abnormal_limbs/digits/tail_de0.80781447
89MP0004147_increased_porphyrin_level0.79786090
90MP0001919_abnormal_reproductive_system0.79498834
91MP0002163_abnormal_gland_morphology0.79413763
92MP0002102_abnormal_ear_morphology0.79282953
93MP0005084_abnormal_gallbladder_morpholo0.79009122
94MP0005075_abnormal_melanosome_morpholog0.78902575
95MP0003186_abnormal_redox_activity0.78475964
96MP0009840_abnormal_foam_cell0.78176753
97MP0002751_abnormal_autonomic_nervous0.78056871
98MP0005397_hematopoietic_system_phenotyp0.76765784
99MP0001545_abnormal_hematopoietic_system0.76765784
100MP0003195_calcinosis0.75458369
101MP0006035_abnormal_mitochondrial_morpho0.73689706
102MP0005384_cellular_phenotype0.72144661
103MP0004808_abnormal_hematopoietic_stem0.71554205
104MP0002233_abnormal_nose_morphology0.71329867
105MP0009672_abnormal_birth_weight0.71253409
106MP0009703_decreased_birth_body0.70821979
107MP0005621_abnormal_cell_physiology0.70805496
108MP0005253_abnormal_eye_physiology0.70767787
109MP0001764_abnormal_homeostasis0.69814037
110MP0000490_abnormal_crypts_of0.69536796
111MP0006292_abnormal_olfactory_placode0.69271293
112MP0000647_abnormal_sebaceous_gland0.68965052
113MP0002132_abnormal_respiratory_system0.68798086
114MP0000631_abnormal_neuroendocrine_gland0.67957215
115MP0003755_abnormal_palate_morphology0.67621148
116MP0005623_abnormal_meninges_morphology0.66163772
117MP0002111_abnormal_tail_morphology0.65788914
118MP0002396_abnormal_hematopoietic_system0.64832714
119MP0004133_heterotaxia0.64696489
120MP0003938_abnormal_ear_development0.63911133
121MP0002092_abnormal_eye_morphology0.62245343
122MP0000432_abnormal_head_morphology0.61841294
123MP0001968_abnormal_touch/_nociception0.61373327
124MP0009053_abnormal_anal_canal0.61106671
125MP0000428_abnormal_craniofacial_morphol0.61063220
126MP0004019_abnormal_vitamin_homeostasis0.60963198
127MP0005499_abnormal_olfactory_system0.60717008
128MP0005394_taste/olfaction_phenotype0.60717008
129MP0001881_abnormal_mammary_gland0.60019885
130MP0003890_abnormal_embryonic-extraembry0.59992456
131MP0005023_abnormal_wound_healing0.59302862
132MP0005451_abnormal_body_composition0.58787582
133MP0009333_abnormal_splenocyte_physiolog0.58250711
134MP0000516_abnormal_urinary_system0.58088529
135MP0005367_renal/urinary_system_phenotyp0.58088529
136MP0005257_abnormal_intraocular_pressure0.55402233
137MP0003705_abnormal_hypodermis_morpholog0.54915803
138MP0000627_abnormal_mammary_gland0.54833256
139MP0003950_abnormal_plasma_membrane0.53624416
140MP0002269_muscular_atrophy0.52478857
141MP0003221_abnormal_cardiomyocyte_apopto0.50976951

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.34440481
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.28300461
3Acute necrotizing encephalopathy (HP:0006965)4.95720034
4Birth length less than 3rd percentile (HP:0003561)4.71022047
5Impulsivity (HP:0100710)4.67126997
6Dynein arm defect of respiratory motile cilia (HP:0012255)4.59433084
7Absent/shortened dynein arms (HP:0200106)4.59433084
8Acute encephalopathy (HP:0006846)4.40850332
9Abnormal mitochondria in muscle tissue (HP:0008316)4.40603403
10Carpal bone hypoplasia (HP:0001498)4.35480533
11Increased hepatocellular lipid droplets (HP:0006565)4.31057310
12Mitochondrial inheritance (HP:0001427)4.17878159
13Abnormal spermatogenesis (HP:0008669)4.16593957
14Progressive macrocephaly (HP:0004481)4.01286288
15Abnormality of the anterior horn cell (HP:0006802)3.97269925
16Degeneration of anterior horn cells (HP:0002398)3.97269925
17Lipid accumulation in hepatocytes (HP:0006561)3.93744962
18Increased CSF lactate (HP:0002490)3.79624904
19Abnormal respiratory epithelium morphology (HP:0012253)3.72582100
20Abnormal respiratory motile cilium morphology (HP:0005938)3.72582100
21Colon cancer (HP:0003003)3.66510859
22Azoospermia (HP:0000027)3.59997824
23Cerebral hypomyelination (HP:0006808)3.40822492
24Septo-optic dysplasia (HP:0100842)3.40471835
25Hepatocellular necrosis (HP:0001404)3.38796090
26Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.36523303
27Rough bone trabeculation (HP:0100670)3.36270053
28Cerebral edema (HP:0002181)3.34260179
29Abnormal respiratory motile cilium physiology (HP:0012261)3.31078542
30Absent radius (HP:0003974)3.29730658
31Ureteral duplication (HP:0000073)3.21324958
32Renal Fanconi syndrome (HP:0001994)3.16907895
33Decreased activity of mitochondrial respiratory chain (HP:0008972)3.14062512
34Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.14062512
35Patellar aplasia (HP:0006443)3.10362574
36Male infertility (HP:0003251)3.08958723
37Aplasia involving forearm bones (HP:0009822)3.07606628
38Absent forearm bone (HP:0003953)3.07606628
39Chronic bronchitis (HP:0004469)3.06838841
40Infertility (HP:0000789)3.06772208
41Rhinitis (HP:0012384)3.04210144
42Aplasia/Hypoplasia of the patella (HP:0006498)3.03683736
43Meckel diverticulum (HP:0002245)2.96178254
44Abnormality of the labia minora (HP:0012880)2.94281202
45Aplastic anemia (HP:0001915)2.92517921
46Hepatic necrosis (HP:0002605)2.91286817
47Congenital, generalized hypertrichosis (HP:0004540)2.87357986
48Secondary amenorrhea (HP:0000869)2.81067399
49Absent thumb (HP:0009777)2.79773499
50Methylmalonic acidemia (HP:0002912)2.79741766
51Abnormality of the ileum (HP:0001549)2.79039895
52Type I transferrin isoform profile (HP:0003642)2.78213177
53Premature ovarian failure (HP:0008209)2.77186779
54Selective tooth agenesis (HP:0001592)2.73676882
55Aplasia/hypoplasia of the humerus (HP:0006507)2.72415177
56Abnormality of methionine metabolism (HP:0010901)2.68428105
57Exertional dyspnea (HP:0002875)2.67800937
58Increased intramyocellular lipid droplets (HP:0012240)2.67519370
59Leukodystrophy (HP:0002415)2.66993599
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66440294
613-Methylglutaconic aciduria (HP:0003535)2.65035048
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63271537
63Abnormality of serum amino acid levels (HP:0003112)2.62084557
64Chromsome breakage (HP:0040012)2.60035887
65Homocystinuria (HP:0002156)2.59553876
66Abnormality of homocysteine metabolism (HP:0010919)2.59553876
67Supernumerary spleens (HP:0009799)2.56973521
68Abnormality of cells of the erythroid lineage (HP:0012130)2.56129270
69Abnormality of aspartate family amino acid metabolism (HP:0010899)2.53135458
70Abnormality of the preputium (HP:0100587)2.51959378
71Abnormal lung lobation (HP:0002101)2.51622336
72Reticulocytopenia (HP:0001896)2.51038589
73Pallor (HP:0000980)2.49756797
74Multiple enchondromatosis (HP:0005701)2.48768362
75Methylmalonic aciduria (HP:0012120)2.48584013
76Premature rupture of membranes (HP:0001788)2.48325121
77Increased serum lactate (HP:0002151)2.48112948
78Lactic acidosis (HP:0003128)2.46235429
79Stenosis of the external auditory canal (HP:0000402)2.45181577
80Trismus (HP:0000211)2.43286904
81Aplasia/Hypoplasia involving the musculature (HP:0001460)2.43225758
82Reduced antithrombin III activity (HP:0001976)2.43168623
83Abnormality of the umbilical cord (HP:0010881)2.41340464
84Aplasia/Hypoplasia of the uvula (HP:0010293)2.38692912
85Progressive muscle weakness (HP:0003323)2.38342659
86Hyperglycinemia (HP:0002154)2.38264221
87Respiratory difficulties (HP:0002880)2.38101407
88Abnormality of chromosome stability (HP:0003220)2.37787484
89Atrophy/Degeneration involving motor neurons (HP:0007373)2.36559703
90Ankle contracture (HP:0006466)2.36355577
91Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35955494
92Abnormal trabecular bone morphology (HP:0100671)2.35099119
93Horseshoe kidney (HP:0000085)2.34550987
94Respiratory failure (HP:0002878)2.33674966
95Megaloblastic anemia (HP:0001889)2.32266207
96Bilateral microphthalmos (HP:0007633)2.31761703
97Duplicated collecting system (HP:0000081)2.31619299
98Abnormal ciliary motility (HP:0012262)2.29152312
99Absent septum pellucidum (HP:0001331)2.28419653
100Exercise intolerance (HP:0003546)2.28370273
101Abnormal number of erythroid precursors (HP:0012131)2.27254363
102Hypoplasia of the radius (HP:0002984)2.26581434
103Oral leukoplakia (HP:0002745)2.24956592
104Facial cleft (HP:0002006)2.20656095
105Macrocytic anemia (HP:0001972)2.18334175
106Hypoplasia of the capital femoral epiphysis (HP:0003090)2.17288837
107Optic disc pallor (HP:0000543)2.16517291
108Facial hemangioma (HP:0000329)2.16189033
109Abnormality of the septum pellucidum (HP:0007375)2.16088039
110Increased muscle lipid content (HP:0009058)2.14954786
111Abnormality of renal resorption (HP:0011038)2.14383971
112Cleft eyelid (HP:0000625)2.12770277
113Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.12667896
114Abnormal protein N-linked glycosylation (HP:0012347)2.12667896
115Abnormal protein glycosylation (HP:0012346)2.12667896
116Abnormal glycosylation (HP:0012345)2.12667896
117Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11804680
118Hypoplasia of the pons (HP:0012110)2.10479061
119Short humerus (HP:0005792)2.09254384
120Pancytopenia (HP:0001876)2.09180872
121Maternal diabetes (HP:0009800)2.04657068
122Personality changes (HP:0000751)2.04239517
123Lethargy (HP:0001254)2.03481823
124Sparse eyelashes (HP:0000653)2.03249355
125Sparse lateral eyebrow (HP:0005338)2.03233685
126Triphalangeal thumb (HP:0001199)2.02314876
127Cellular immunodeficiency (HP:0005374)2.00533611
128Difficulty climbing stairs (HP:0003551)2.00399164
129Spinal muscular atrophy (HP:0007269)1.96902200
130Neoplasm of the pancreas (HP:0002894)1.96748667
131Oligodactyly (HP:0012165)1.96422730
132Nephroblastoma (Wilms tumor) (HP:0002667)1.96299997
133Duodenal stenosis (HP:0100867)1.96274613
134Small intestinal stenosis (HP:0012848)1.96274613
135Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96129144
136Breast aplasia (HP:0100783)1.95745747
137Abnormality of the pons (HP:0007361)1.95673513
138Microretrognathia (HP:0000308)1.95351719
139Bone marrow hypocellularity (HP:0005528)1.95340780
140Abnormality of the lower motor neuron (HP:0002366)1.95032078
141Transposition of the great arteries (HP:0001669)1.94520529
142Abnormal connection of the cardiac segments (HP:0011545)1.94520529
143Abnormal ventriculo-arterial connection (HP:0011563)1.94520529
144CNS hypomyelination (HP:0003429)1.94250197
145Sloping forehead (HP:0000340)1.90969894
146Abnormality of serine family amino acid metabolism (HP:0010894)1.90197874
147Abnormality of glycine metabolism (HP:0010895)1.90197874
148Abnormality of the duodenum (HP:0002246)1.90023003
149Aplasia/Hypoplasia of the breasts (HP:0010311)1.88953265
150Premature graying of hair (HP:0002216)1.88686922
151Breech presentation (HP:0001623)1.86952299
152Atresia of the external auditory canal (HP:0000413)1.86806831
153Tongue fasciculations (HP:0001308)1.84764157
154Embryonal renal neoplasm (HP:0011794)1.84237149
155Concave nail (HP:0001598)1.83307229
156Microvesicular hepatic steatosis (HP:0001414)1.83102272
157Aplasia/Hypoplasia of the earlobes (HP:0009906)1.82893090
158Abnormality of the renal collecting system (HP:0004742)1.82594686
159Abnormality of sulfur amino acid metabolism (HP:0004339)1.82207963
160Pendular nystagmus (HP:0012043)1.81469666
161Squamous cell carcinoma (HP:0002860)1.80155159
162Abnormal number of incisors (HP:0011064)1.79468023
163Short thumb (HP:0009778)1.79078418
164Gonadotropin excess (HP:0000837)1.78902981
165Areflexia of lower limbs (HP:0002522)1.76500499
166Muscle fibrillation (HP:0010546)1.76323564
167Hyperglycinuria (HP:0003108)1.76001669
168Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75699885
169Absent epiphyses (HP:0010577)1.75699885
170Neoplasm of the colon (HP:0100273)1.73721264
171Optic nerve hypoplasia (HP:0000609)1.71517827
172Spastic diplegia (HP:0001264)1.69517344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.95968060
2BUB14.55002649
3WEE14.32161554
4PDK33.90611170
5PDK43.90611170
6MST43.18335758
7NEK23.16508924
8PDK22.84116201
9EIF2AK12.74366592
10EPHA22.73367124
11NME22.71836606
12TTK2.58173720
13PLK42.57580817
14SRPK12.52105413
15TAF12.47254340
16CDC72.43839404
17CDK192.22800939
18AKT32.13155214
19TNIK2.09944263
20TESK12.07432087
21PLK12.05848942
22NUAK12.04493104
23PNCK1.95609976
24DYRK31.95114854
25STK38L1.89843710
26BRSK21.85360402
27ACVR1B1.74010966
28NEK11.73417314
29TESK21.70899434
30LATS21.63304306
31STK161.60697249
32CHEK21.60679878
33ZAK1.59671071
34TSSK61.50326240
35WNK31.49177259
36PLK31.48343956
37EIF2AK31.36836294
38OXSR11.33443414
39AURKB1.32334998
40MKNK21.30818207
41STK31.27611981
42AURKA1.23671977
43BMPR1B1.22602835
44PINK11.18609072
45ICK1.14078224
46MKNK11.12606928
47CHEK11.11903371
48BRSK11.10441028
49CDK71.10083749
50TLK11.08309217
51ATR1.07818056
52TRIM281.03939355
53BRAF1.03341919
54PRKD31.01972692
55RPS6KA40.94398363
56IRAK30.92701164
57CDK120.90619025
58CSNK1G10.88932912
59STK380.86901342
60MAP3K120.86619756
61ERBB40.85995735
62VRK10.84867735
63KDR0.84716134
64CCNB10.84427427
65BCKDK0.83921172
66PAK40.82749791
67PAK10.82045204
68MAP4K20.81570814
69MAP3K80.81364106
70CDK40.78815502
71PIM20.75856491
72RPS6KB20.74096988
73GRK10.72411441
74NME10.72078304
75CDK20.70999816
76DAPK10.70655864
77ATM0.70323007
78CSNK1G30.68835658
79PRKCI0.66790622
80ALK0.66287913
81DYRK20.66260766
82DDR20.64794503
83CSNK1G20.64715856
84TIE10.63978029
85CSNK2A10.62349720
86CSNK2A20.61910838
87STK40.61101016
88EIF2AK20.57700824
89FLT30.57696943
90PIM10.55693291
91PBK0.55284756
92ARAF0.54668857
93INSRR0.54618167
94CDK10.50917548
95MELK0.49909715
96NLK0.48814652
97CSNK1E0.48552069
98MTOR0.47967755
99LATS10.46809530
100ABL20.46257199
101FGFR10.46118640
102MAP3K100.45147533
103PLK20.44476330
104ADRBK20.42848798
105CSNK1A1L0.42672424
106MYLK0.38509498
107DAPK30.38429788
108WNK40.38298073
109PASK0.37903462
110TEC0.37280596
111RPS6KA50.36564776
112ILK0.34165939
113TYRO30.31926106
114STK390.28128218
115MAP3K30.25711237
116DYRK1B0.24840845
117STK240.24036270
118PRKCG0.23840979
119CDK80.22702549
120MARK30.21721101
121PAK20.21720677
122TXK0.21428145
123PRKDC0.20658765
124SMG10.20015015
125EGFR0.19592990
126STK100.15014197
127MOS0.14752716
128GSK3B0.13456663
129CDK30.13240308
130CDK60.13187885
131CSNK1D0.12908043
132IRAK20.12554164
133CDC42BPA0.11495242
134NEK60.10971911
135PTK2B0.10716284
136IRAK10.10516740
137MAPK100.09648867
138PRKAA10.09481415
139CSNK1A10.08383733
140MAPK140.08253274

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.52504956
2RNA polymerase_Homo sapiens_hsa030204.24596438
3Vitamin B6 metabolism_Homo sapiens_hsa007504.14638368
4Proteasome_Homo sapiens_hsa030503.95139716
5RNA transport_Homo sapiens_hsa030133.66211876
6DNA replication_Homo sapiens_hsa030303.44076399
7Ribosome_Homo sapiens_hsa030103.32078190
8Spliceosome_Homo sapiens_hsa030403.02819170
9Basal transcription factors_Homo sapiens_hsa030222.96583143
10Mismatch repair_Homo sapiens_hsa034302.94963855
11Pyrimidine metabolism_Homo sapiens_hsa002402.76097641
12Homologous recombination_Homo sapiens_hsa034402.61388957
13Fanconi anemia pathway_Homo sapiens_hsa034602.59488393
14Cell cycle_Homo sapiens_hsa041102.48318899
15Nucleotide excision repair_Homo sapiens_hsa034202.47032140
16Base excision repair_Homo sapiens_hsa034102.13937955
17Alzheimers disease_Homo sapiens_hsa050102.13707953
18mRNA surveillance pathway_Homo sapiens_hsa030151.88058512
19One carbon pool by folate_Homo sapiens_hsa006701.80940426
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76544783
21Purine metabolism_Homo sapiens_hsa002301.72020416
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69526767
23RNA degradation_Homo sapiens_hsa030181.62229831
24p53 signaling pathway_Homo sapiens_hsa041151.50210485
25Oocyte meiosis_Homo sapiens_hsa041141.48121401
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.47342198
27Pentose phosphate pathway_Homo sapiens_hsa000301.42565464
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.32684803
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.29886550
30Epstein-Barr virus infection_Homo sapiens_hsa051691.24471897
31Regulation of autophagy_Homo sapiens_hsa041401.22041897
32Non-homologous end-joining_Homo sapiens_hsa034501.19615729
33Selenocompound metabolism_Homo sapiens_hsa004501.17905833
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16666667
35Folate biosynthesis_Homo sapiens_hsa007901.07251984
36Propanoate metabolism_Homo sapiens_hsa006401.06045567
37Huntingtons disease_Homo sapiens_hsa050161.02573323
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02473545
39Fructose and mannose metabolism_Homo sapiens_hsa000510.95440341
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.94158410
41Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90773435
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.86647553
43Glutathione metabolism_Homo sapiens_hsa004800.85254250
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84275635
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83884432
46Fatty acid elongation_Homo sapiens_hsa000620.83648634
47Biosynthesis of amino acids_Homo sapiens_hsa012300.82247137
48Sulfur relay system_Homo sapiens_hsa041220.82227362
49Linoleic acid metabolism_Homo sapiens_hsa005910.81827142
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.80201076
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79094898
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.78535627
53Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74396817
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65186107
55Steroid biosynthesis_Homo sapiens_hsa001000.61372846
56Systemic lupus erythematosus_Homo sapiens_hsa053220.58593868
57Carbon metabolism_Homo sapiens_hsa012000.57578006
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.57033578
59Arachidonic acid metabolism_Homo sapiens_hsa005900.55698646
60Cyanoamino acid metabolism_Homo sapiens_hsa004600.54975723
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54960036
62Antigen processing and presentation_Homo sapiens_hsa046120.52519793
63Viral carcinogenesis_Homo sapiens_hsa052030.52221176
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52060348
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50695501
66Chemical carcinogenesis_Homo sapiens_hsa052040.50522019
67Retinol metabolism_Homo sapiens_hsa008300.48327014
68Phototransduction_Homo sapiens_hsa047440.47848536
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46706127
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45688331
71Metabolic pathways_Homo sapiens_hsa011000.45353292
72Herpes simplex infection_Homo sapiens_hsa051680.41900693
73Hippo signaling pathway_Homo sapiens_hsa043900.41216514
74Asthma_Homo sapiens_hsa053100.40547638
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40303693
76HTLV-I infection_Homo sapiens_hsa051660.37816958
77Hedgehog signaling pathway_Homo sapiens_hsa043400.37738062
78beta-Alanine metabolism_Homo sapiens_hsa004100.35978898
79Vitamin digestion and absorption_Homo sapiens_hsa049770.35906539
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.35848132
81Caffeine metabolism_Homo sapiens_hsa002320.35296792
82Peroxisome_Homo sapiens_hsa041460.33971149
83Arginine and proline metabolism_Homo sapiens_hsa003300.33649882
84Tryptophan metabolism_Homo sapiens_hsa003800.32629317
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31298487
86Pyruvate metabolism_Homo sapiens_hsa006200.30989351
87Glycerolipid metabolism_Homo sapiens_hsa005610.28493397
88mTOR signaling pathway_Homo sapiens_hsa041500.28456438
89Sulfur metabolism_Homo sapiens_hsa009200.27982086
90Tight junction_Homo sapiens_hsa045300.27953075
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27700536
92Parkinsons disease_Homo sapiens_hsa050120.27355372
93Protein export_Homo sapiens_hsa030600.26539755
94Renin-angiotensin system_Homo sapiens_hsa046140.26204470
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26201283
96Fatty acid biosynthesis_Homo sapiens_hsa000610.25481961
97N-Glycan biosynthesis_Homo sapiens_hsa005100.24816819
98Oxidative phosphorylation_Homo sapiens_hsa001900.24598759
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23832743
100Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23137551
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21859256
102MicroRNAs in cancer_Homo sapiens_hsa052060.21663884
103Mineral absorption_Homo sapiens_hsa049780.21427405
104TGF-beta signaling pathway_Homo sapiens_hsa043500.21257455
105Fatty acid degradation_Homo sapiens_hsa000710.19898983
106Butanoate metabolism_Homo sapiens_hsa006500.17685719
107Fat digestion and absorption_Homo sapiens_hsa049750.16738871
108Ether lipid metabolism_Homo sapiens_hsa005650.16260597
109Tyrosine metabolism_Homo sapiens_hsa003500.15943645
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.15786373
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.15256220
112Small cell lung cancer_Homo sapiens_hsa052220.15083573
113Collecting duct acid secretion_Homo sapiens_hsa049660.14377245
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.13905384
115HIF-1 signaling pathway_Homo sapiens_hsa040660.13816589
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.13169490
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.13006023
118Thyroid cancer_Homo sapiens_hsa052160.12255440
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10946053
120Taste transduction_Homo sapiens_hsa047420.10535777
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.10459075
122Primary immunodeficiency_Homo sapiens_hsa053400.09333504
123Galactose metabolism_Homo sapiens_hsa000520.07928053
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.07568962
125Sphingolipid metabolism_Homo sapiens_hsa006000.07548284
126Basal cell carcinoma_Homo sapiens_hsa052170.05198280
127Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.04973314
128Legionellosis_Homo sapiens_hsa051340.04569708
129Wnt signaling pathway_Homo sapiens_hsa043100.02877999
130Glucagon signaling pathway_Homo sapiens_hsa049220.02657683
131AMPK signaling pathway_Homo sapiens_hsa041520.02473943
1322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.01620828
133Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0296171
134Cardiac muscle contraction_Homo sapiens_hsa04260-0.0282133
135Prostate cancer_Homo sapiens_hsa05215-0.0015069

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