ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.33474685
2	viral transcription (GO:0019083)	5.25522179
3	translational termination (GO:0006415)	5.13658580
4	maturation of SSU-rRNA (GO:0030490)	4.94574259
5	response to pheromone (GO:0019236)	4.76427794
6	cotranslational protein targeting to membrane (GO:0006613)	4.71733075
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.67185789
8	protein targeting to ER (GO:0045047)	4.59122985
9	ribosomal small subunit biogenesis (GO:0042274)	4.41041128
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.37178271
11	protein localization to endoplasmic reticulum (GO:0070972)	4.31133945
12	translational elongation (GO:0006414)	4.21498262
13	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.03319664
14	pattern specification involved in kidney development (GO:0061004)	4.01600314
15	behavioral response to nicotine (GO:0035095)	3.99265299
16	cellular protein complex disassembly (GO:0043624)	3.89905094
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.83385279
18	protein heterotetramerization (GO:0051290)	3.80167267
19	translational initiation (GO:0006413)	3.79062647
20	peptidyl-histidine modification (GO:0018202)	3.78567143
21	viral life cycle (GO:0019058)	3.78128560
22	axonemal dynein complex assembly (GO:0070286)	3.73346323
23	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.72417989
24	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.72417989
25	NADH dehydrogenase complex assembly (GO:0010257)	3.72417989
26	protein complex biogenesis (GO:0070271)	3.51837426
27	chaperone-mediated protein transport (GO:0072321)	3.51414814
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.50129214
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.50129214
30	aldehyde catabolic process (GO:0046185)	3.42658923
31	protein complex disassembly (GO:0043241)	3.41139815
32	macromolecular complex disassembly (GO:0032984)	3.36541459
33	preassembly of GPI anchor in ER membrane (GO:0016254)	3.35974264
34	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.35125952
35	replication fork processing (GO:0031297)	3.29513894
36	nonmotile primary cilium assembly (GO:0035058)	3.26113279
37	protein targeting to membrane (GO:0006612)	3.23005756
38	regulation of cilium movement (GO:0003352)	3.20467457
39	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	3.18234600
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13977823
41	translation (GO:0006412)	3.05982947
42	cytochrome complex assembly (GO:0017004)	3.05230283
43	response to redox state (GO:0051775)	3.03639765
44	short-term memory (GO:0007614)	3.03418076
45	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.02161416
46	ATP synthesis coupled proton transport (GO:0015986)	3.02161416
47	pseudouridine synthesis (GO:0001522)	3.01925487
48	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.00812654
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.00495012
50	ribosomal large subunit biogenesis (GO:0042273)	2.97434726
51	platelet dense granule organization (GO:0060155)	2.97205842
52	intraciliary transport (GO:0042073)	2.95941749
53	respiratory chain complex IV assembly (GO:0008535)	2.95491781
54	cell proliferation in forebrain (GO:0021846)	2.93966835
55	kinetochore assembly (GO:0051382)	2.93482226
56	protein neddylation (GO:0045116)	2.92825756
57	cellular component biogenesis (GO:0044085)	2.91788944
58	somite development (GO:0061053)	2.89856751
59	cellular response to zinc ion (GO:0071294)	2.88437571
60	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.86887308
61	lens fiber cell development (GO:0070307)	2.86699002
62	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.85668885
63	mRNA catabolic process (GO:0006402)	2.85498358
64	organelle disassembly (GO:1903008)	2.84095335
65	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.81104477
66	rRNA catabolic process (GO:0016075)	2.80843785
67	arginine catabolic process (GO:0006527)	2.80078315
68	mannosylation (GO:0097502)	2.78458279
69	resolution of meiotic recombination intermediates (GO:0000712)	2.77694975
70	ribonucleoprotein complex disassembly (GO:0032988)	2.76302995
71	regulation of microtubule-based movement (GO:0060632)	2.75336143
72	pyrimidine nucleobase catabolic process (GO:0006208)	2.74944534
73	centriole replication (GO:0007099)	2.73366079
74	DNA replication checkpoint (GO:0000076)	2.72368630
75	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.71259628
76	ncRNA catabolic process (GO:0034661)	2.70315347
77	regulation of meiosis I (GO:0060631)	2.69548286
78	kinetochore organization (GO:0051383)	2.68885387
79	protein polyglutamylation (GO:0018095)	2.68475256
80	C-terminal protein lipidation (GO:0006501)	2.68226176
81	electron transport chain (GO:0022900)	2.67926127
82	ribonucleoprotein complex biogenesis (GO:0022613)	2.67043215
83	respiratory electron transport chain (GO:0022904)	2.66303330
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.65689370
85	RNA catabolic process (GO:0006401)	2.61415679
86	chromatin remodeling at centromere (GO:0031055)	2.59142427
87	C-terminal protein amino acid modification (GO:0018410)	2.55057256
88	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.52532449
89	detection of light stimulus involved in visual perception (GO:0050908)	2.51187045
90	detection of light stimulus involved in sensory perception (GO:0050962)	2.51187045
91	termination of RNA polymerase III transcription (GO:0006386)	2.49810627
92	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.49810627
93	negative regulation of appetite (GO:0032099)	2.49659492
94	negative regulation of response to food (GO:0032096)	2.49659492
95	pyrimidine dimer repair (GO:0006290)	2.49496737
96	postreplication repair (GO:0006301)	2.48154992
97	CENP-A containing nucleosome assembly (GO:0034080)	2.42800363
98	limb bud formation (GO:0060174)	2.42788638
99	axoneme assembly (GO:0035082)	2.41702760
100	regulation of mitochondrial translation (GO:0070129)	2.41588984

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.21116620
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.68452370
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.65879745
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.20407486
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.77967896
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.71736209
7	ELK1_19687146_ChIP-ChIP_HELA_Human	2.63942199
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.48738725
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.43047712
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.33322941
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.32822715
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.29965920
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.29798327
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.24430076
15	IRF1_19129219_ChIP-ChIP_H3396_Human	2.22755604
16	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.22066538
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.17448561
18	VDR_22108803_ChIP-Seq_LS180_Human	2.06217169
19	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03099266
20	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.02235184
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.91807863
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.85657261
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.84305446
24	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.73371703
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.73314788
26	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.64394254
27	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.62705171
28	VDR_23849224_ChIP-Seq_CD4+_Human	1.60095510
29	P300_19829295_ChIP-Seq_ESCs_Human	1.59221256
30	E2F7_22180533_ChIP-Seq_HELA_Human	1.58409666
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.56471585
32	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.55463394
33	FUS_26573619_Chip-Seq_HEK293_Human	1.52219947
34	EWS_26573619_Chip-Seq_HEK293_Human	1.49750310
35	GABP_19822575_ChIP-Seq_HepG2_Human	1.49549655
36	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.47792167
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.46173805
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.45648025
39	TTF2_22483619_ChIP-Seq_HELA_Human	1.45010741
40	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.44916275
41	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.44365091
42	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39827916
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38162902
44	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34263075
45	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.33942337
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33418059
47	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.33178301
48	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.32970559
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.31531709
50	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.25082349
51	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.18814340
52	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.18103720
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16153388
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16153388
55	CBP_20019798_ChIP-Seq_JUKART_Human	1.15113417
56	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.15113417
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.14598406
58	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.14021522
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.12959051
60	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.12046489
61	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12006779
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.09346149
63	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.09297680
64	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.07119825
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.06983191
66	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05676136
67	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.04358119
68	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.02307731
69	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.01594359
70	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.99367019
71	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.99289109
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.99000163
73	KDM5A_27292631_Chip-Seq_BREAST_Human	0.98078442
74	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.97869377
75	ER_23166858_ChIP-Seq_MCF-7_Human	0.96781795
76	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.95338495
77	NCOR_22424771_ChIP-Seq_293T_Human	0.94944738
78	RNF2_27304074_Chip-Seq_NSC_Mouse	0.94679585
79	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.94590008
80	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.94315308
81	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.93848667
82	XRN2_22483619_ChIP-Seq_HELA_Human	0.93604281
83	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.93134768
84	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92096423
85	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.91536748
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.90676513
87	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.90298696
88	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.89737229
89	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.88900488
90	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.88684499
91	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.87057951
92	STAT6_21828071_ChIP-Seq_BEAS2B_Human	0.86909364
93	NANOG_20526341_ChIP-Seq_ESCs_Human	0.86598631
94	TP53_16413492_ChIP-PET_HCT116_Human	0.85689059
95	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.85302001
96	GBX2_23144817_ChIP-Seq_PC3_Human	0.83416490
97	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.83206544
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.83206544
99	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.82895858
100	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.81797564

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.53764000
2	MP0003787_abnormal_imprinting	3.18996127
3	MP0006292_abnormal_olfactory_placode	2.99405471
4	MP0008877_abnormal_DNA_methylation	2.57315507
5	MP0001293_anophthalmia	2.54685693
6	MP0010030_abnormal_orbit_morphology	2.28590442
7	MP0002282_abnormal_trachea_morphology	2.25595682
8	MP0003121_genomic_imprinting	2.25317002
9	MP0004142_abnormal_muscle_tone	2.20378372
10	MP0006276_abnormal_autonomic_nervous	2.18768343
11	MP0003880_abnormal_central_pattern	2.16812130
12	MP0003186_abnormal_redox_activity	1.98714449
13	MP0008789_abnormal_olfactory_epithelium	1.97735836
14	MP0000372_irregular_coat_pigmentation	1.93863782
15	MP0003122_maternal_imprinting	1.90205779
16	MP0002938_white_spotting	1.88886028
17	MP0003136_yellow_coat_color	1.86975200
18	MP0004145_abnormal_muscle_electrophysio	1.83226885
19	MP0008058_abnormal_DNA_repair	1.82046513
20	MP0005551_abnormal_eye_electrophysiolog	1.68262667
21	MP0001984_abnormal_olfaction	1.67128479
22	MP0008872_abnormal_physiological_respon	1.65217156
23	MP0000516_abnormal_urinary_system	1.63839612
24	MP0005367_renal/urinary_system_phenotyp	1.63839612
25	MP0008995_early_reproductive_senescence	1.57683675
26	MP0000778_abnormal_nervous_system	1.55639788
27	MP0004133_heterotaxia	1.53026548
28	MP0000631_abnormal_neuroendocrine_gland	1.51927614
29	MP0000427_abnormal_hair_cycle	1.50926932
30	MP0006072_abnormal_retinal_apoptosis	1.49894222
31	MP0001485_abnormal_pinna_reflex	1.48818467
32	MP0003937_abnormal_limbs/digits/tail_de	1.47722182
33	MP0001348_abnormal_lacrimal_gland	1.45870732
34	MP0002876_abnormal_thyroid_physiology	1.42901785
35	MP0001986_abnormal_taste_sensitivity	1.39464972
36	MP0002653_abnormal_ependyma_morphology	1.39293047
37	MP0003941_abnormal_skin_development	1.39117482
38	MP0002102_abnormal_ear_morphology	1.37993725
39	MP0008057_abnormal_DNA_replication	1.37194501
40	MP0005394_taste/olfaction_phenotype	1.36555463
41	MP0005499_abnormal_olfactory_system	1.36555463
42	MP0001529_abnormal_vocalization	1.36126735
43	MP0003693_abnormal_embryo_hatching	1.35776299
44	MP0009250_abnormal_appendicular_skeleto	1.34534870
45	MP0002138_abnormal_hepatobiliary_system	1.32918132
46	MP0010094_abnormal_chromosome_stability	1.30126580
47	MP0000049_abnormal_middle_ear	1.29426093
48	MP0003950_abnormal_plasma_membrane	1.26426195
49	MP0002233_abnormal_nose_morphology	1.25951971
50	MP0002697_abnormal_eye_size	1.22500378
51	MP0001286_abnormal_eye_development	1.21245662
52	MP0005195_abnormal_posterior_eye	1.19826150
53	MP0006035_abnormal_mitochondrial_morpho	1.18918368
54	MP0002736_abnormal_nociception_after	1.18300703
55	MP0003786_premature_aging	1.18204746
56	MP0005253_abnormal_eye_physiology	1.17164229
57	MP0009046_muscle_twitch	1.15608070
58	MP0002210_abnormal_sex_determination	1.09581618
59	MP0002557_abnormal_social/conspecific_i	1.09249373
60	MP0005423_abnormal_somatic_nervous	1.09003290
61	MP0002638_abnormal_pupillary_reflex	1.08451087
62	MP0005084_abnormal_gallbladder_morpholo	1.07118954
63	MP0000358_abnormal_cell_content/	1.06777623
64	MP0003938_abnormal_ear_development	1.05971207
65	MP0005391_vision/eye_phenotype	1.04602856
66	MP0002752_abnormal_somatic_nervous	1.03961988
67	MP0001968_abnormal_touch/_nociception	1.03427936
68	MP0003890_abnormal_embryonic-extraembry	1.02544633
69	MP0003755_abnormal_palate_morphology	1.01777019
70	MP0004957_abnormal_blastocyst_morpholog	1.01621499
71	MP0001929_abnormal_gametogenesis	0.98548833
72	MP0002132_abnormal_respiratory_system	0.97598292
73	MP0004043_abnormal_pH_regulation	0.96952622
74	MP0008775_abnormal_heart_ventricle	0.96691304
75	MP0002272_abnormal_nervous_system	0.94999552
76	MP0003123_paternal_imprinting	0.93377690
77	MP0001346_abnormal_lacrimal_gland	0.92952120
78	MP0008932_abnormal_embryonic_tissue	0.92757296
79	MP0002928_abnormal_bile_duct	0.91041207
80	MP0005408_hypopigmentation	0.90753973
81	MP0002234_abnormal_pharynx_morphology	0.90727097
82	MP0003718_maternal_effect	0.88718170
83	MP0004147_increased_porphyrin_level	0.88021739
84	MP0002095_abnormal_skin_pigmentation	0.87739537
85	MP0002734_abnormal_mechanical_nocicepti	0.87282689
86	MP0003698_abnormal_male_reproductive	0.86469363
87	MP0001905_abnormal_dopamine_level	0.85909381
88	MP0000955_abnormal_spinal_cord	0.83924263
89	MP0004924_abnormal_behavior	0.83698297
90	MP0005386_behavior/neurological_phenoty	0.83698297
91	MP0005377_hearing/vestibular/ear_phenot	0.82689957
92	MP0003878_abnormal_ear_physiology	0.82689957
93	MP0002184_abnormal_innervation	0.82522085
94	MP0001145_abnormal_male_reproductive	0.80514679
95	MP0002277_abnormal_respiratory_mucosa	0.80510133
96	MP0001119_abnormal_female_reproductive	0.79594735
97	MP0003283_abnormal_digestive_organ	0.78746742
98	MP0003942_abnormal_urinary_system	0.78483949
99	MP0002090_abnormal_vision	0.77612373
100	MP0002160_abnormal_reproductive_system	0.76389679

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.67841533
2	Aplasia/Hypoplasia of the sacrum (HP:0008517)	4.00832206
3	Septo-optic dysplasia (HP:0100842)	3.86937700
4	Bifid tongue (HP:0010297)	3.65407206
5	Acute necrotizing encephalopathy (HP:0006965)	3.59963966
6	Acute encephalopathy (HP:0006846)	3.46582416
7	Abnormality of cells of the erythroid lineage (HP:0012130)	3.27399740
8	Bilateral microphthalmos (HP:0007633)	3.24333534
9	Type 2 muscle fiber atrophy (HP:0003554)	3.23991606
10	Abnormality of the labia minora (HP:0012880)	3.10284686
11	Abnormal mitochondria in muscle tissue (HP:0008316)	3.01260810
12	Progressive macrocephaly (HP:0004481)	2.97358336
13	Anophthalmia (HP:0000528)	2.93705837
14	Medial flaring of the eyebrow (HP:0010747)	2.92825729
15	Rib fusion (HP:0000902)	2.91240694
16	Molar tooth sign on MRI (HP:0002419)	2.81654086
17	Abnormality of midbrain morphology (HP:0002418)	2.81654086
18	Pancreatic fibrosis (HP:0100732)	2.78034128
19	Absent septum pellucidum (HP:0001331)	2.73403914
20	Pancreatic cysts (HP:0001737)	2.71043407
21	Muscle fiber atrophy (HP:0100295)	2.71026090
22	Chorioretinal atrophy (HP:0000533)	2.65417609
23	Nephrogenic diabetes insipidus (HP:0009806)	2.65282972
24	Increased CSF lactate (HP:0002490)	2.65075751
25	Mitochondrial inheritance (HP:0001427)	2.64505063
26	Hepatocellular necrosis (HP:0001404)	2.64145129
27	Nephronophthisis (HP:0000090)	2.61089908
28	Abnormality of DNA repair (HP:0003254)	2.60025197
29	Abnormal number of erythroid precursors (HP:0012131)	2.54308003
30	Colon cancer (HP:0003003)	2.52256584
31	Occipital encephalocele (HP:0002085)	2.52038020
32	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.50542194
33	Decreased muscle mass (HP:0003199)	2.48487263
34	Congenital primary aphakia (HP:0007707)	2.45758297
35	Stenosis of the external auditory canal (HP:0000402)	2.44842520
36	Gait imbalance (HP:0002141)	2.44552390
37	Vaginal atresia (HP:0000148)	2.44540441
38	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.39855643
39	Growth hormone deficiency (HP:0000824)	2.38687740
40	True hermaphroditism (HP:0010459)	2.33505892
41	Genital tract atresia (HP:0001827)	2.31797789
42	Cerebral edema (HP:0002181)	2.30564627
43	Abnormality of the septum pellucidum (HP:0007375)	2.28773664
44	Poikiloderma (HP:0001029)	2.27738031
45	Bell-shaped thorax (HP:0001591)	2.26278078
46	Tubular atrophy (HP:0000092)	2.25689790
47	Hepatic necrosis (HP:0002605)	2.24923753
48	Macrocytic anemia (HP:0001972)	2.24128950
49	Optic nerve hypoplasia (HP:0000609)	2.21485655
50	Hyperglycinemia (HP:0002154)	2.21377414
51	Short middle phalanx of the 5th finger (HP:0004220)	2.19678545
52	Hip dysplasia (HP:0001385)	2.19531573
53	Polyphagia (HP:0002591)	2.17234761
54	Absent thumb (HP:0009777)	2.16039408
55	11 pairs of ribs (HP:0000878)	2.16004300
56	Sclerocornea (HP:0000647)	2.13964734
57	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.13625575
58	Missing ribs (HP:0000921)	2.12968560
59	Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)	2.11519450
60	Bicornuate uterus (HP:0000813)	2.10879561
61	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.09586979
62	Anencephaly (HP:0002323)	2.08953172
63	Small hand (HP:0200055)	2.08919303
64	Abnormality of the renal medulla (HP:0100957)	2.07790210
65	Adrenal hypoplasia (HP:0000835)	2.06998301
66	Aplasia/hypoplasia of the uterus (HP:0008684)	2.05410813
67	Asplenia (HP:0001746)	2.03014882
68	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.02510684
69	Absent epiphyses (HP:0010577)	2.02510684
70	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00947015
71	Hypokinesia (HP:0002375)	2.00788062
72	Hypoplasia of the uterus (HP:0000013)	1.99804975
73	Febrile seizures (HP:0002373)	1.98884728
74	Poor suck (HP:0002033)	1.94440853
75	Pendular nystagmus (HP:0012043)	1.92982986
76	Neonatal respiratory distress (HP:0002643)	1.91549589
77	Horseshoe kidney (HP:0000085)	1.91330464
78	Optic disc pallor (HP:0000543)	1.90925962
79	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.89851403
80	Type II lissencephaly (HP:0007260)	1.89798105
81	Hypoplasia of the capital femoral epiphysis (HP:0003090)	1.84381098
82	Abnormality of the neuromuscular junction (HP:0003398)	1.82317524
83	Fatigable weakness (HP:0003473)	1.82317524
84	Chronic hepatic failure (HP:0100626)	1.82175322
85	Narrow forehead (HP:0000341)	1.80199301
86	Tubulointerstitial nephritis (HP:0001970)	1.79953328
87	Abnormality of the ileum (HP:0001549)	1.79232919
88	Ectopic kidney (HP:0000086)	1.78545317
89	Hyperglycinuria (HP:0003108)	1.78019099
90	Pallor (HP:0000980)	1.77524617
91	Hypoplasia of the ulna (HP:0003022)	1.76931480
92	Hypoplastic iliac wings (HP:0002866)	1.76669191
93	Cystic liver disease (HP:0006706)	1.76567305
94	Abnormal hemoglobin (HP:0011902)	1.76522968
95	Triphalangeal thumb (HP:0001199)	1.76395435
96	Maternal diabetes (HP:0009800)	1.75935811
97	Abnormal rod and cone electroretinograms (HP:0008323)	1.75603360
98	Supernumerary spleens (HP:0009799)	1.75093373
99	Left ventricular hypertrophy (HP:0001712)	1.75036941
100	Hypoplastic pelvis (HP:0008839)	1.75015858

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	6.24835028
2	STK16	3.06670439
3	TRIM28	3.00223400
4	CASK	2.84597582
5	ZAK	2.53819712
6	BCR	2.46775921
7	WNK4	2.32285645
8	MAP3K12	2.26845749
9	PDK2	2.20997516
10	FRK	1.97000155
11	PLK4	1.92820877
12	CDK8	1.91766445
13	EIF2AK3	1.84125979
14	TNIK	1.82055078
15	STK39	1.74893343
16	MAP2K7	1.73485168
17	BMPR1B	1.69113536
18	EIF2AK1	1.69080141
19	MAP4K2	1.69072671
20	MAP3K4	1.64939076
21	DYRK2	1.62000872
22	PLK2	1.48798969
23	PBK	1.48283216
24	INSRR	1.45298342
25	GRK1	1.38055451
26	LRRK2	1.31233355
27	MKNK2	1.25701192
28	MST4	1.22755881
29	SRPK1	1.21597982
30	PRKCI	1.15578451
31	NUAK1	1.14793321
32	AKT3	1.12339991
33	ADRBK2	1.11642666
34	OXSR1	1.06925097
35	PLK3	1.04115945
36	PAK3	1.00326332
37	MINK1	0.99625609
38	VRK2	0.95037633
39	KSR1	0.92675137
40	WNK3	0.91067256
41	TAF1	0.89292054
42	PLK1	0.88586622
43	PAK6	0.87704293
44	CDC7	0.87135104
45	BRSK2	0.87117882
46	WEE1	0.86259632
47	EPHB2	0.85196729
48	MAPK13	0.84690183
49	TGFBR1	0.80909504
50	EPHA4	0.78099092
51	PINK1	0.77393064
52	DAPK3	0.75816875
53	TESK2	0.72601545
54	MAP2K4	0.72497902
55	PRKCG	0.70582131
56	MARK3	0.70508138
57	CDK19	0.69368683
58	ATR	0.67941966
59	ADRBK1	0.62450560
60	CSNK1G2	0.62136451
61	AURKB	0.61629890
62	AKT2	0.61127531
63	BCKDK	0.58670605
64	CHEK2	0.57997895
65	NME1	0.57237850
66	BRSK1	0.56646341
67	NTRK2	0.55858264
68	DYRK3	0.55440453
69	NEK1	0.54866800
70	SGK223	0.50422126
71	SGK494	0.50422126
72	STK38L	0.49893950
73	BRAF	0.49854809
74	TTK	0.47921523
75	MAP3K11	0.47210792
76	CSNK2A2	0.46637628
77	MKNK1	0.46109267
78	PRKCE	0.45742576
79	PASK	0.45551431
80	LIMK1	0.43969743
81	CSNK1G1	0.43161603
82	ABL2	0.42392289
83	PIK3CA	0.41952655
84	AURKA	0.41405391
85	ERBB3	0.39729978
86	DMPK	0.38542408
87	NEK6	0.38262903
88	CAMK1	0.38061029
89	CSNK1E	0.37652824
90	TIE1	0.37465906
91	CSNK2A1	0.37181423
92	MAPKAPK5	0.36913535
93	PKN1	0.36538836
94	PRKACA	0.36504977
95	SIK3	0.35603523
96	MYLK	0.35347182
97	PRKCH	0.35079850
98	ERBB4	0.32529645
99	CSNK1G3	0.32421000
100	PRKCQ	0.32227020

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.62012814
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.03880017
3	Protein export_Homo sapiens_hsa03060	2.67095855
4	Proteasome_Homo sapiens_hsa03050	2.66522606
5	Parkinsons disease_Homo sapiens_hsa05012	2.65541601
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.64694762
7	Fanconi anemia pathway_Homo sapiens_hsa03460	2.61622763
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51389080
9	Homologous recombination_Homo sapiens_hsa03440	2.49593864
10	Propanoate metabolism_Homo sapiens_hsa00640	2.48928381
11	Basal transcription factors_Homo sapiens_hsa03022	2.39012658
12	Huntingtons disease_Homo sapiens_hsa05016	1.98973472
13	Mismatch repair_Homo sapiens_hsa03430	1.98963991
14	RNA polymerase_Homo sapiens_hsa03020	1.93385807
15	RNA degradation_Homo sapiens_hsa03018	1.82808570
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.82157028
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.79984207
18	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79524580
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.69435710
20	DNA replication_Homo sapiens_hsa03030	1.68201347
21	Alzheimers disease_Homo sapiens_hsa05010	1.64901509
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.63473771
23	Base excision repair_Homo sapiens_hsa03410	1.63437779
24	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.60019480
25	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.56690601
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.48181041
27	Steroid biosynthesis_Homo sapiens_hsa00100	1.47649300
28	Phototransduction_Homo sapiens_hsa04744	1.45378039
29	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.43348494
30	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.41192409
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.40360944
32	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.34789231
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33248700
34	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.27110718
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.25309689
36	Glutathione metabolism_Homo sapiens_hsa00480	1.20957161
37	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.18462371
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.18439188
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18014442
40	Butanoate metabolism_Homo sapiens_hsa00650	1.13850620
41	RNA transport_Homo sapiens_hsa03013	1.13435100
42	Fat digestion and absorption_Homo sapiens_hsa04975	1.09972205
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.09078604
44	Peroxisome_Homo sapiens_hsa04146	1.07670525
45	beta-Alanine metabolism_Homo sapiens_hsa00410	1.00983938
46	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.96006850
47	Pyruvate metabolism_Homo sapiens_hsa00620	0.95331878
48	Caffeine metabolism_Homo sapiens_hsa00232	0.92008882
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.87355455
50	Metabolic pathways_Homo sapiens_hsa01100	0.84322552
51	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.84216705
52	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80592398
53	Fatty acid degradation_Homo sapiens_hsa00071	0.79370272
54	Purine metabolism_Homo sapiens_hsa00230	0.78825283
55	Sulfur relay system_Homo sapiens_hsa04122	0.78123187
56	Hippo signaling pathway_Homo sapiens_hsa04390	0.77876959
57	Olfactory transduction_Homo sapiens_hsa04740	0.77372383
58	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75136258
59	p53 signaling pathway_Homo sapiens_hsa04115	0.74306114
60	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73891519
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.72394049
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72029449
63	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.70528945
64	Mineral absorption_Homo sapiens_hsa04978	0.69559426
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.66726005
66	Spliceosome_Homo sapiens_hsa03040	0.66019848
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64738442
68	One carbon pool by folate_Homo sapiens_hsa00670	0.63864134
69	Cell cycle_Homo sapiens_hsa04110	0.63539567
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.62370184
71	Fatty acid elongation_Homo sapiens_hsa00062	0.58530396
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58045000
73	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.55746843
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.54208818
75	Folate biosynthesis_Homo sapiens_hsa00790	0.52905382
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.51023315
77	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.49954113
78	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47802766
79	Nicotine addiction_Homo sapiens_hsa05033	0.47349069
80	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.46136460
81	Insulin secretion_Homo sapiens_hsa04911	0.46117559
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.45408179
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.45079876
84	Retinol metabolism_Homo sapiens_hsa00830	0.43234805
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36592530
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36230918
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.35399324
88	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35160483
89	Selenocompound metabolism_Homo sapiens_hsa00450	0.34875847
90	Carbon metabolism_Homo sapiens_hsa01200	0.33964712
91	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.31379791
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27744890
93	Wnt signaling pathway_Homo sapiens_hsa04310	0.25782539
94	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.23938590
95	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.23683347
96	Regulation of autophagy_Homo sapiens_hsa04140	0.23005788
97	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.22457396
98	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.20784721
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.17246345
100	Taste transduction_Homo sapiens_hsa04742	0.15772579

RPL39P36

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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