ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	8.26916206
2	substrate-independent telencephalic tangential migration (GO:0021826)	8.26916206
3	nonmotile primary cilium assembly (GO:0035058)	6.34877180
4	behavioral response to nicotine (GO:0035095)	6.16672660
5	somite development (GO:0061053)	5.26517414
6	viral transcription (GO:0019083)	5.09580505
7	translational termination (GO:0006415)	4.93070668
8	ovulation cycle (GO:0042698)	4.91925364
9	left/right axis specification (GO:0070986)	4.79865349
10	thalamus development (GO:0021794)	4.59404037
11	segment specification (GO:0007379)	4.57057660
12	spinal cord association neuron differentiation (GO:0021527)	4.56278288
13	pyrimidine nucleobase catabolic process (GO:0006208)	4.53016805
14	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	4.17873729
15	maturation of SSU-rRNA (GO:0030490)	4.17161717
16	membrane repolarization (GO:0086009)	4.10989215
17	pattern specification involved in kidney development (GO:0061004)	4.07872333
18	ribosomal small subunit assembly (GO:0000028)	4.05487175
19	regulation of bile acid biosynthetic process (GO:0070857)	4.04706500
20	positive regulation of neurological system process (GO:0031646)	4.01648578
21	cotranslational protein targeting to membrane (GO:0006613)	4.00522207
22	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.00033854
23	vocalization behavior (GO:0071625)	3.93134801
24	embryonic retina morphogenesis in camera-type eye (GO:0060059)	3.91660128
25	protein targeting to ER (GO:0045047)	3.89861245
26	translational elongation (GO:0006414)	3.82411127
27	tongue development (GO:0043586)	3.77442907
28	ribosomal small subunit biogenesis (GO:0042274)	3.73931222
29	axon ensheathment in central nervous system (GO:0032291)	3.71890357
30	central nervous system myelination (GO:0022010)	3.71890357
31	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.70620397
32	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.70442766
33	positive regulation of T cell apoptotic process (GO:0070234)	3.68851146
34	protein localization to endoplasmic reticulum (GO:0070972)	3.68483244
35	cellular protein complex disassembly (GO:0043624)	3.66162993
36	viral life cycle (GO:0019058)	3.63271501
37	nucleobase catabolic process (GO:0046113)	3.62559048
38	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.61227634
39	tyrosine phosphorylation of STAT protein (GO:0007260)	3.59701920
40	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	3.56974881
41	inner mitochondrial membrane organization (GO:0007007)	3.55486260
42	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.52195562
43	cell proliferation in forebrain (GO:0021846)	3.50621739
44	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.48235837
45	regulation of female gonad development (GO:2000194)	3.47449705
46	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	3.47376526
47	homocysteine metabolic process (GO:0050667)	3.46378370
48	cerebellar Purkinje cell differentiation (GO:0021702)	3.42690375
49	potassium ion import (GO:0010107)	3.33239492
50	sodium ion export (GO:0071436)	3.32068694
51	neurotransmitter catabolic process (GO:0042135)	3.29580012
52	urogenital system development (GO:0001655)	3.29541640
53	dendritic spine morphogenesis (GO:0060997)	3.24346635
54	forebrain neuron development (GO:0021884)	3.24185844
55	neuron cell-cell adhesion (GO:0007158)	3.22829645
56	synaptic transmission, cholinergic (GO:0007271)	3.18517682
57	cellular potassium ion homeostasis (GO:0030007)	3.16492341
58	regulation of transmission of nerve impulse (GO:0051969)	3.13613495
59	positive regulation of gastrulation (GO:2000543)	3.07968909
60	protein complex disassembly (GO:0043241)	3.07380297
61	head development (GO:0060322)	3.06243238
62	S-adenosylmethionine metabolic process (GO:0046500)	3.03904151
63	regulation of neuron migration (GO:2001222)	3.01216318
64	indolalkylamine metabolic process (GO:0006586)	3.00834385
65	positive regulation of lymphocyte apoptotic process (GO:0070230)	3.00604066
66	negative regulation of DNA-templated transcription, elongation (GO:0032785)	3.00418016
67	telencephalon development (GO:0021537)	3.00291005
68	regulation of potassium ion transmembrane transporter activity (GO:1901016)	3.00165805
69	serine family amino acid catabolic process (GO:0009071)	2.95814105
70	sulfate transport (GO:0008272)	2.95251828
71	macromolecular complex disassembly (GO:0032984)	2.94108774
72	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.93192489
73	cardiovascular system development (GO:0072358)	2.91089695
74	neuron recognition (GO:0008038)	2.89792548
75	amine catabolic process (GO:0009310)	2.88279508
76	cellular biogenic amine catabolic process (GO:0042402)	2.88279508
77	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	2.87994014
78	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.87513879
79	resolution of meiotic recombination intermediates (GO:0000712)	2.84066024
80	oxidative demethylation (GO:0070989)	2.83923701
81	axonal fasciculation (GO:0007413)	2.82708702
82	epithelial cilium movement (GO:0003351)	2.82161931
83	cilium or flagellum-dependent cell motility (GO:0001539)	2.81873530
84	retina layer formation (GO:0010842)	2.80396710
85	postsynaptic membrane organization (GO:0001941)	2.79667464
86	thyroid hormone generation (GO:0006590)	2.78569641
87	positive regulation of protein homooligomerization (GO:0032464)	2.75862929
88	positive regulation of mitochondrial fission (GO:0090141)	2.70963010
89	protein targeting to membrane (GO:0006612)	2.69955542
90	viral protein processing (GO:0019082)	2.68642262
91	regulation of cilium movement (GO:0003352)	2.68026793
92	collecting duct development (GO:0072044)	2.65674771
93	translational initiation (GO:0006413)	2.63776183
94	presynaptic membrane organization (GO:0097090)	2.63492665
95	somite rostral/caudal axis specification (GO:0032525)	2.62297719
96	cellular sodium ion homeostasis (GO:0006883)	2.61576424
97	sulfate transmembrane transport (GO:1902358)	2.59349496
98	phenol-containing compound catabolic process (GO:0019336)	2.58979529
99	retinal ganglion cell axon guidance (GO:0031290)	2.58754672
100	potassium ion homeostasis (GO:0055075)	2.58516638

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	7.21864306
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.62370542
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.10945134
4	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.07973935
5	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.76119886
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.25090763
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.20335151
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.13110913
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.10154340
10	VDR_22108803_ChIP-Seq_LS180_Human	2.08685918
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.02751722
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.02563958
13	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.01706779
14	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99767449
15	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.97833645
16	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.92299153
17	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.92281681
18	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.92197033
19	IRF1_19129219_ChIP-ChIP_H3396_Human	1.85381943
20	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77474834
21	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.73667975
22	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.70845731
23	RNF2_27304074_Chip-Seq_NSC_Mouse	1.69603008
24	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.65474320
25	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64602975
26	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.63054529
27	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.63054529
28	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.55883925
29	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.55318947
30	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.52944608
31	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.47980131
32	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.45062687
33	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43677869
34	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.42809507
35	GBX2_23144817_ChIP-Seq_PC3_Human	1.41530101
36	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.39355301
37	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.38368778
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.37828036
39	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.36609962
40	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.35915795
41	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34644929
42	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33418818
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.31173892
44	CTCF_27219007_Chip-Seq_Bcells_Human	1.29357710
45	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.28925995
46	NCOR_22424771_ChIP-Seq_293T_Human	1.26466602
47	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.26064945
48	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.23725174
49	IGF1R_20145208_ChIP-Seq_DFB_Human	1.23118278
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22394658
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.22046983
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20111017
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.19260828
54	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14604374
55	DROSHA_22980978_ChIP-Seq_HELA_Human	1.11938760
56	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.10817004
57	SA1_27219007_Chip-Seq_Bcells_Human	1.10517367
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.10442691
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10435492
60	NANOG_20526341_ChIP-Seq_ESCs_Human	1.09430432
61	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.07869857
62	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.07064480
63	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06982557
64	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.06874234
65	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.05661221
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.04934760
67	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	1.04670878
68	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.03536630
69	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.02511575
70	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02357787
71	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.02268615
72	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01963591
73	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01499640
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99563000
75	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.98399139
76	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.98172848
77	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.98115459
78	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.96740906
79	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96572640
80	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.96572640
81	P300_19829295_ChIP-Seq_ESCs_Human	0.94181242
82	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93938020
83	CBP_20019798_ChIP-Seq_JUKART_Human	0.93938020
84	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.92014983
85	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.91818981
86	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.87665184
87	ERA_21632823_ChIP-Seq_H3396_Human	0.85223499
88	AR_19668381_ChIP-Seq_PC3_Human	0.83307567
89	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.82635981
90	OCT4_20526341_ChIP-Seq_ESCs_Human	0.82402992
91	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.82185411
92	SRY_22984422_ChIP-ChIP_TESTIS_Rat	0.81917648
93	STAT3_23295773_ChIP-Seq_U87_Human	0.81385987
94	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.80625548
95	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.78527123
96	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.77846329
97	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.77472639
98	RUNX2_22187159_ChIP-Seq_PCA_Human	0.76349338
99	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.76290552
100	OCT4_19829295_ChIP-Seq_ESCs_Human	0.76064306

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	6.85567705
2	MP0003787_abnormal_imprinting	3.83813838
3	MP0009379_abnormal_foot_pigmentation	3.81705691
4	MP0003122_maternal_imprinting	3.51838342
5	MP0008877_abnormal_DNA_methylation	2.88806571
6	MP0003315_abnormal_perineum_morphology	2.84709331
7	MP0005423_abnormal_somatic_nervous	2.43562284
8	MP0002254_reproductive_system_inflammat	2.32807256
9	MP0003121_genomic_imprinting	2.31132540
10	MP0006276_abnormal_autonomic_nervous	2.30816539
11	MP0005646_abnormal_pituitary_gland	2.26190921
12	MP0000778_abnormal_nervous_system	2.13591195
13	MP0002876_abnormal_thyroid_physiology	2.04013746
14	MP0001293_anophthalmia	1.99790903
15	MP0003880_abnormal_central_pattern	1.88568652
16	MP0005083_abnormal_biliary_tract	1.88023906
17	MP0008789_abnormal_olfactory_epithelium	1.86537092
18	MP0005499_abnormal_olfactory_system	1.80203614
19	MP0005394_taste/olfaction_phenotype	1.80203614
20	MP0004742_abnormal_vestibular_system	1.71499457
21	MP0000049_abnormal_middle_ear	1.68430472
22	MP0005171_absent_coat_pigmentation	1.66235721
23	MP0003646_muscle_fatigue	1.66077127
24	MP0001188_hyperpigmentation	1.65652575
25	MP0000955_abnormal_spinal_cord	1.64611104
26	MP0005551_abnormal_eye_electrophysiolog	1.64571027
27	MP0005187_abnormal_penis_morphology	1.63900443
28	MP0004142_abnormal_muscle_tone	1.63757574
29	MP0001984_abnormal_olfaction	1.61180440
30	MP0003123_paternal_imprinting	1.60968813
31	MP0003938_abnormal_ear_development	1.59965710
32	MP0005360_urolithiasis	1.59714621
33	MP0000613_abnormal_salivary_gland	1.52448984
34	MP0002095_abnormal_skin_pigmentation	1.49345926
35	MP0002653_abnormal_ependyma_morphology	1.47346992
36	MP0002184_abnormal_innervation	1.47173069
37	MP0005085_abnormal_gallbladder_physiolo	1.44891295
38	MP0004133_heterotaxia	1.43941765
39	MP0002102_abnormal_ear_morphology	1.38990987
40	MP0003136_yellow_coat_color	1.37997524
41	MP0002272_abnormal_nervous_system	1.37266932
42	MP0002557_abnormal_social/conspecific_i	1.35941790
43	MP0002638_abnormal_pupillary_reflex	1.33644654
44	MP0004145_abnormal_muscle_electrophysio	1.31589900
45	MP0008875_abnormal_xenobiotic_pharmacok	1.29519718
46	MP0005195_abnormal_posterior_eye	1.28422897
47	MP0002752_abnormal_somatic_nervous	1.24363955
48	MP0003878_abnormal_ear_physiology	1.24186292
49	MP0005377_hearing/vestibular/ear_phenot	1.24186292
50	MP0006072_abnormal_retinal_apoptosis	1.23440318
51	MP0001502_abnormal_circadian_rhythm	1.15584815
52	MP0005084_abnormal_gallbladder_morpholo	1.13992307
53	MP0002837_dystrophic_cardiac_calcinosis	1.13442852
54	MP0001970_abnormal_pain_threshold	1.11207986
55	MP0003635_abnormal_synaptic_transmissio	1.10687140
56	MP0010386_abnormal_urinary_bladder	1.08872043
57	MP0002138_abnormal_hepatobiliary_system	1.04708113
58	MP0002882_abnormal_neuron_morphology	1.03029773
59	MP0004859_abnormal_synaptic_plasticity	1.01852608
60	MP0001324_abnormal_eye_pigmentation	1.01339201
61	MP0009046_muscle_twitch	1.01066057
62	MP0002572_abnormal_emotion/affect_behav	1.00799914
63	MP0002938_white_spotting	0.98461585
64	MP0009745_abnormal_behavioral_response	0.98452725
65	MP0002909_abnormal_adrenal_gland	0.97007430
66	MP0001286_abnormal_eye_development	0.96901978
67	MP0000534_abnormal_ureter_morphology	0.96825235
68	MP0000026_abnormal_inner_ear	0.95287482
69	MP0000538_abnormal_urinary_bladder	0.94778816
70	MP0002160_abnormal_reproductive_system	0.92983294
71	MP0003942_abnormal_urinary_system	0.92878134
72	MP0002733_abnormal_thermal_nociception	0.92181844
73	MP0005389_reproductive_system_phenotype	0.89467314
74	MP0002063_abnormal_learning/memory/cond	0.88741203
75	MP0002152_abnormal_brain_morphology	0.87069336
76	MP0001348_abnormal_lacrimal_gland	0.83912014
77	MP0002210_abnormal_sex_determination	0.83535234
78	MP0002734_abnormal_mechanical_nocicepti	0.81124368
79	MP0002277_abnormal_respiratory_mucosa	0.81101071
80	MP0004019_abnormal_vitamin_homeostasis	0.80327911
81	MP0001485_abnormal_pinna_reflex	0.80195824
82	MP0001968_abnormal_touch/_nociception	0.80020318
83	MP0002064_seizures	0.79402718
84	MP0000647_abnormal_sebaceous_gland	0.78594088
85	MP0003861_abnormal_nervous_system	0.77307073
86	MP0002229_neurodegeneration	0.75972266
87	MP0005365_abnormal_bile_salt	0.71273249
88	MP0002928_abnormal_bile_duct	0.70375866
89	MP0003936_abnormal_reproductive_system	0.69429368
90	MP0002067_abnormal_sensory_capabilities	0.68469379
91	MP0002233_abnormal_nose_morphology	0.68224433
92	MP0005391_vision/eye_phenotype	0.67944602
93	MP0001270_distended_abdomen	0.67924266
94	MP0008995_early_reproductive_senescence	0.67093689
95	MP0005253_abnormal_eye_physiology	0.66965814
96	MP0002163_abnormal_gland_morphology	0.66080872
97	MP0005257_abnormal_intraocular_pressure	0.65625139
98	MP0002932_abnormal_joint_morphology	0.65105985
99	MP0003186_abnormal_redox_activity	0.63722619
100	MP0002736_abnormal_nociception_after	0.63349520

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of midbrain morphology (HP:0002418)	5.51885652
2	Molar tooth sign on MRI (HP:0002419)	5.51885652
3	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.93266571
4	Reticulocytopenia (HP:0001896)	4.90819331
5	Pendular nystagmus (HP:0012043)	3.98973728
6	Pancreatic fibrosis (HP:0100732)	3.76875506
7	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.57685980
8	Myokymia (HP:0002411)	3.55019680
9	Abnormality of cells of the erythroid lineage (HP:0012130)	3.41998509
10	Abnormal pancreas size (HP:0012094)	3.33696321
11	Limb dystonia (HP:0002451)	3.32733949
12	Abnormal rod and cone electroretinograms (HP:0008323)	3.32118615
13	True hermaphroditism (HP:0010459)	3.30368318
14	Anencephaly (HP:0002323)	3.24810846
15	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.19565384
16	Amblyopia (HP:0000646)	3.14531330
17	Asplenia (HP:0001746)	3.11432109
18	Pancreatic cysts (HP:0001737)	2.97027957
19	Urinary bladder sphincter dysfunction (HP:0002839)	2.85267076
20	Medial flaring of the eyebrow (HP:0010747)	2.80204479
21	Increased corneal curvature (HP:0100692)	2.78222583
22	Keratoconus (HP:0000563)	2.78222583
23	Stenosis of the external auditory canal (HP:0000402)	2.75736850
24	Microretrognathia (HP:0000308)	2.73843482
25	Cystic liver disease (HP:0006706)	2.70257285
26	Lissencephaly (HP:0001339)	2.58384547
27	Type II lissencephaly (HP:0007260)	2.50859980
28	Gait imbalance (HP:0002141)	2.50666693
29	Shawl scrotum (HP:0000049)	2.49725482
30	Depressed nasal ridge (HP:0000457)	2.49721385
31	Absent thumb (HP:0009777)	2.45220399
32	Abnormal hemoglobin (HP:0011902)	2.42743212
33	Partial agenesis of the corpus callosum (HP:0001338)	2.42400879
34	Chronic bronchitis (HP:0004469)	2.38517761
35	Macrocytic anemia (HP:0001972)	2.38405616
36	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.36278144
37	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.34720526
38	Abnormal number of erythroid precursors (HP:0012131)	2.34327697
39	Nephronophthisis (HP:0000090)	2.33084019
40	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.30637641
41	Supernumerary spleens (HP:0009799)	2.28112263
42	Genetic anticipation (HP:0003743)	2.27269850
43	Pallor (HP:0000980)	2.26325695
44	Agitation (HP:0000713)	2.26038579
45	Hypoplasia of the brainstem (HP:0002365)	2.24769060
46	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.24769060
47	Anosmia (HP:0000458)	2.24332790
48	Congenital stationary night blindness (HP:0007642)	2.22088724
49	Tented upper lip vermilion (HP:0010804)	2.22008315
50	Congenital primary aphakia (HP:0007707)	2.21729730
51	Rib fusion (HP:0000902)	2.18302314
52	Decreased central vision (HP:0007663)	2.16557947
53	Sclerocornea (HP:0000647)	2.13264106
54	Abnormality of cochlea (HP:0000375)	2.10316276
55	Abnormality of alanine metabolism (HP:0010916)	2.09406918
56	Hyperalaninemia (HP:0003348)	2.09406918
57	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.09406918
58	Partial duplication of thumb phalanx (HP:0009944)	2.08933590
59	Congenital sensorineural hearing impairment (HP:0008527)	2.07832769
60	Acute necrotizing encephalopathy (HP:0006965)	2.06920515
61	Postaxial foot polydactyly (HP:0001830)	2.05822558
62	Hypogonadotrophic hypogonadism (HP:0000044)	2.05692064
63	Status epilepticus (HP:0002133)	2.03833805
64	Abnormality of the renal medulla (HP:0100957)	2.01334756
65	Ectopic kidney (HP:0000086)	2.01316243
66	Large eyes (HP:0001090)	2.00591795
67	Chronic hepatic failure (HP:0100626)	1.99099384
68	Thyroid-stimulating hormone excess (HP:0002925)	1.97874217
69	Nephrogenic diabetes insipidus (HP:0009806)	1.97520976
70	Pigmentary retinal degeneration (HP:0001146)	1.95154522
71	Enlarged kidneys (HP:0000105)	1.95124351
72	Severe Myopia (HP:0011003)	1.94622032
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.94499453
74	Septo-optic dysplasia (HP:0100842)	1.93733041
75	Narrow forehead (HP:0000341)	1.93313995
76	Congenital hepatic fibrosis (HP:0002612)	1.90689200
77	Male pseudohermaphroditism (HP:0000037)	1.90285245
78	Dandy-Walker malformation (HP:0001305)	1.89232644
79	Retinal dysplasia (HP:0007973)	1.88897483
80	Mitochondrial inheritance (HP:0001427)	1.88361241
81	Morphological abnormality of the inner ear (HP:0011390)	1.88282050
82	Adrenal hypoplasia (HP:0000835)	1.87893649
83	Abnormal respiratory motile cilium physiology (HP:0012261)	1.87640495
84	Atonic seizures (HP:0010819)	1.87089977
85	Renal dysplasia (HP:0000110)	1.85077177
86	Decreased circulating renin level (HP:0003351)	1.83759613
87	Esotropia (HP:0000565)	1.83743027
88	Aganglionic megacolon (HP:0002251)	1.82573845
89	Optic nerve hypoplasia (HP:0000609)	1.82563912
90	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.81865364
91	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81330693
92	Oligomenorrhea (HP:0000876)	1.80317001
93	Hypomagnesemia (HP:0002917)	1.79391318
94	Abnormality of magnesium homeostasis (HP:0004921)	1.78362532
95	Progressive cerebellar ataxia (HP:0002073)	1.78010774
96	Myotonia (HP:0002486)	1.77474577
97	Tubular atrophy (HP:0000092)	1.75856630
98	Absent/shortened dynein arms (HP:0200106)	1.72667306
99	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.72667306
100	Fused cervical vertebrae (HP:0002949)	1.72282074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EPHB2	4.47476713
2	STK16	3.58487467
3	CASK	3.42099890
4	BCKDK	2.71739751
5	MAP3K11	2.47551709
6	MAP2K7	2.45585515
7	WNK4	2.45387333
8	PINK1	2.44540915
9	MAP4K2	2.07693505
10	KSR1	2.07644790
11	NTRK2	2.07027145
12	PTK6	2.00497860
13	MARK1	1.99749861
14	CAMK1D	1.91897402
15	MUSK	1.91829629
16	DYRK2	1.79721180
17	WNK3	1.77210679
18	CAMK1G	1.71737692
19	EPHA4	1.68322496
20	ADRBK2	1.67074587
21	TAOK3	1.61187786
22	TAOK1	1.53394691
23	MAPK13	1.49401965
24	PAK3	1.48455090
25	MAP3K4	1.43465219
26	PRKCI	1.39094633
27	DYRK1B	1.36404970
28	STK11	1.34819702
29	TNIK	1.34360589
30	MARK2	1.33242670
31	IRAK1	1.28525812
32	GRK1	1.23757234
33	PIM2	1.22096890
34	PRKCG	1.19409084
35	MAPK7	1.17461877
36	FRK	1.16188156
37	LIMK1	1.15882471
38	MAP2K4	1.10648873
39	PHKG1	1.04274742
40	PHKG2	1.04274742
41	RPS6KA6	0.99172099
42	DAPK3	0.92783871
43	PRKCZ	0.90960813
44	NUAK1	0.89594240
45	RPS6KL1	0.86800239
46	RPS6KC1	0.86800239
47	MARK3	0.86561880
48	DMPK	0.79162898
49	MINK1	0.77350402
50	PLK2	0.77227362
51	CAMK1	0.77078463
52	LRRK2	0.76385431
53	ADRBK1	0.72778298
54	CAMK2D	0.72731205
55	DYRK3	0.70734888
56	AURKA	0.70728132
57	RPS6KA2	0.68727351
58	PNCK	0.68657415
59	INSRR	0.66260039
60	ERBB2	0.66208907
61	CHEK2	0.66041388
62	PRKACA	0.66041234
63	STK39	0.65742611
64	PIK3CA	0.65642659
65	PRKCQ	0.64810521
66	MAP3K6	0.62285433
67	TYRO3	0.60774238
68	TIE1	0.59651271
69	BMPR1B	0.56871555
70	RPS6KA4	0.55828333
71	MAP2K6	0.54148707
72	CAMK2A	0.53858285
73	TNK2	0.52274663
74	ROCK1	0.52064441
75	PRKCH	0.50222549
76	OBSCN	0.49342632
77	MAPK15	0.49130201
78	GSK3A	0.48874167
79	ZAK	0.46428620
80	OXSR1	0.46086825
81	CSNK1G2	0.44836656
82	WNK1	0.44469966
83	BRAF	0.44190868
84	AURKB	0.44118622
85	DYRK1A	0.42989384
86	CSNK1E	0.41793507
87	PRKDC	0.41070152
88	IRAK4	0.40127039
89	CAMK2G	0.39325900
90	PRKCA	0.39324442
91	PRKCD	0.39284642
92	PKN1	0.38424687
93	CSNK1A1	0.38151261
94	PRKCE	0.37102668
95	BCR	0.36815855
96	CAMK4	0.36285478
97	SGK223	0.36256606
98	SGK494	0.36256606
99	SGK1	0.35581383
100	MAP4K1	0.34606106

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.09851206
2	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.96196707
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.95453302
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.58884714
5	Parkinsons disease_Homo sapiens_hsa05012	2.47946610
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.38994024
7	Sulfur relay system_Homo sapiens_hsa04122	2.27128111
8	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.25516066
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22477362
10	Nicotine addiction_Homo sapiens_hsa05033	2.18594656
11	Caffeine metabolism_Homo sapiens_hsa00232	2.08558679
12	Huntingtons disease_Homo sapiens_hsa05016	1.90400634
13	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82129497
14	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.75985229
15	Mineral absorption_Homo sapiens_hsa04978	1.75091151
16	Insulin secretion_Homo sapiens_hsa04911	1.73818872
17	Basal transcription factors_Homo sapiens_hsa03022	1.73780754
18	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.73347922
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.73120264
20	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.72198470
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.70309303
22	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.64009993
23	Butanoate metabolism_Homo sapiens_hsa00650	1.62937134
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.60687886
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.54016414
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.53012339
27	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.49370052
28	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48776500
29	Alzheimers disease_Homo sapiens_hsa05010	1.46777862
30	Retinol metabolism_Homo sapiens_hsa00830	1.38750323
31	Peroxisome_Homo sapiens_hsa04146	1.37497584
32	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.36541149
33	Nitrogen metabolism_Homo sapiens_hsa00910	1.26194913
34	Axon guidance_Homo sapiens_hsa04360	1.21174312
35	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.18473168
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.14650437
37	RNA degradation_Homo sapiens_hsa03018	1.13350291
38	Tyrosine metabolism_Homo sapiens_hsa00350	1.13123556
39	Phototransduction_Homo sapiens_hsa04744	1.12449543
40	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.10058059
41	Propanoate metabolism_Homo sapiens_hsa00640	1.08131067
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06946420
43	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.06367565
44	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.05669459
45	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03977089
46	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.03949005
47	Bile secretion_Homo sapiens_hsa04976	1.02784493
48	Phenylalanine metabolism_Homo sapiens_hsa00360	0.98239451
49	Protein export_Homo sapiens_hsa03060	0.97659159
50	Morphine addiction_Homo sapiens_hsa05032	0.96114340
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.95363724
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.93288164
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.93137056
54	Taste transduction_Homo sapiens_hsa04742	0.90509133
55	Fat digestion and absorption_Homo sapiens_hsa04975	0.90461628
56	Ether lipid metabolism_Homo sapiens_hsa00565	0.88219011
57	Fatty acid elongation_Homo sapiens_hsa00062	0.86487385
58	Fatty acid degradation_Homo sapiens_hsa00071	0.86226890
59	Olfactory transduction_Homo sapiens_hsa04740	0.83241952
60	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81138267
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.80644235
62	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80078213
63	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.79908761
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.79721381
65	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.78855934
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.76036043
67	Serotonergic synapse_Homo sapiens_hsa04726	0.75565737
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.74560590
69	GABAergic synapse_Homo sapiens_hsa04727	0.70993579
70	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.69228479
71	Histidine metabolism_Homo sapiens_hsa00340	0.68609452
72	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.68390443
73	One carbon pool by folate_Homo sapiens_hsa00670	0.68042641
74	Metabolic pathways_Homo sapiens_hsa01100	0.65496837
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.64950898
76	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.64790544
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.64417250
78	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.60549684
79	Fatty acid metabolism_Homo sapiens_hsa01212	0.60285966
80	Gastric acid secretion_Homo sapiens_hsa04971	0.59376861
81	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.58706982
82	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57701673
83	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56153915
84	Basal cell carcinoma_Homo sapiens_hsa05217	0.53552336
85	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.50076070
86	cAMP signaling pathway_Homo sapiens_hsa04024	0.49917214
87	Circadian entrainment_Homo sapiens_hsa04713	0.42308588
88	Cocaine addiction_Homo sapiens_hsa05030	0.42133717
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.41548670
90	Homologous recombination_Homo sapiens_hsa03440	0.41276251
91	Cholinergic synapse_Homo sapiens_hsa04725	0.40121206
92	Salivary secretion_Homo sapiens_hsa04970	0.39220689
93	p53 signaling pathway_Homo sapiens_hsa04115	0.36156141
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35175755
95	Pancreatic secretion_Homo sapiens_hsa04972	0.33870931
96	Type II diabetes mellitus_Homo sapiens_hsa04930	0.32437486
97	Complement and coagulation cascades_Homo sapiens_hsa04610	0.31748804
98	Notch signaling pathway_Homo sapiens_hsa04330	0.31302745
99	Arginine and proline metabolism_Homo sapiens_hsa00330	0.30119542
100	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.29525528

RPL39P38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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