ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	glyoxylate metabolic process (GO:0046487)	8.51971620
2	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	6.52193901
3	serine family amino acid catabolic process (GO:0009071)	6.38292549
4	ribosomal small subunit biogenesis (GO:0042274)	6.16385801
5	L-phenylalanine catabolic process (GO:0006559)	5.85671936
6	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.85671936
7	cell-cell junction maintenance (GO:0045217)	5.85481480
8	ribosomal small subunit assembly (GO:0000028)	5.63095265
9	regulation of retinoic acid receptor signaling pathway (GO:0048385)	5.54460636
10	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	5.24689109
11	L-phenylalanine metabolic process (GO:0006558)	5.24689109
12	glycine metabolic process (GO:0006544)	5.13111899
13	cell junction maintenance (GO:0034331)	4.93536513
14	viral transcription (GO:0019083)	4.89817588
15	negative regulation of fibrinolysis (GO:0051918)	4.83398830
16	serine family amino acid metabolic process (GO:0009069)	4.74348387
17	phenylpropanoid metabolic process (GO:0009698)	4.72768637
18	translational termination (GO:0006415)	4.70166535
19	regulation of fibrinolysis (GO:0051917)	4.51951113
20	peptidyl-glutamic acid carboxylation (GO:0017187)	4.50939635
21	protein carboxylation (GO:0018214)	4.50939635
22	male meiosis I (GO:0007141)	4.44471393
23	chaperone-mediated protein transport (GO:0072321)	4.37351158
24	carnitine metabolic process (GO:0009437)	4.26942825
25	amino-acid betaine metabolic process (GO:0006577)	4.23165661
26	aldehyde catabolic process (GO:0046185)	4.20678542
27	regulation of sequestering of triglyceride (GO:0010889)	4.06800676
28	sulfur amino acid catabolic process (GO:0000098)	4.00489158
29	regulation of protein activation cascade (GO:2000257)	3.97649685
30	hormone catabolic process (GO:0042447)	3.96113661
31	oxidative demethylation (GO:0070989)	3.94802473
32	triglyceride homeostasis (GO:0070328)	3.93915119
33	acylglycerol homeostasis (GO:0055090)	3.93915119
34	maturation of SSU-rRNA (GO:0030490)	3.93314303
35	regulation of lipoprotein particle clearance (GO:0010984)	3.92678944
36	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.91803417
37	drug catabolic process (GO:0042737)	3.91490445
38	blood coagulation, intrinsic pathway (GO:0007597)	3.89857678
39	cotranslational protein targeting to membrane (GO:0006613)	3.84991458
40	translational elongation (GO:0006414)	3.84009118
41	protein targeting to ER (GO:0045047)	3.81642635
42	bile acid biosynthetic process (GO:0006699)	3.81446995
43	very-low-density lipoprotein particle assembly (GO:0034379)	3.81246537
44	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.72366777
45	serine family amino acid biosynthetic process (GO:0009070)	3.71801950
46	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.70111981
47	protein localization to endoplasmic reticulum (GO:0070972)	3.70024842
48	urea metabolic process (GO:0019627)	3.69697693
49	viral life cycle (GO:0019058)	3.63427375
50	cellular protein complex disassembly (GO:0043624)	3.62576034
51	positive regulation of lipoprotein lipase activity (GO:0051006)	3.60830232
52	positive regulation of triglyceride lipase activity (GO:0061365)	3.60830232
53	polyketide metabolic process (GO:0030638)	3.59495807
54	doxorubicin metabolic process (GO:0044598)	3.59495807
55	daunorubicin metabolic process (GO:0044597)	3.59495807
56	synapsis (GO:0007129)	3.58020901
57	meiosis I (GO:0007127)	3.57903730
58	fibrinolysis (GO:0042730)	3.56962724
59	cysteine metabolic process (GO:0006534)	3.52741075
60	L-serine metabolic process (GO:0006563)	3.51494889
61	regulation of triglyceride catabolic process (GO:0010896)	3.49773195
62	urea cycle (GO:0000050)	3.45368925
63	bile acid metabolic process (GO:0008206)	3.44949044
64	regulation of complement activation (GO:0030449)	3.35803061
65	pyrimidine nucleobase catabolic process (GO:0006208)	3.31760406
66	nitrogen cycle metabolic process (GO:0071941)	3.31323021
67	piRNA metabolic process (GO:0034587)	3.30383265
68	heme transport (GO:0015886)	3.24674497
69	aromatic amino acid family catabolic process (GO:0009074)	3.21968623
70	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.20465127
71	uronic acid metabolic process (GO:0006063)	3.20363147
72	glucuronate metabolic process (GO:0019585)	3.20363147
73	ubiquinone biosynthetic process (GO:0006744)	3.19939143
74	aminoglycoside antibiotic metabolic process (GO:0030647)	3.16890334
75	cellular glucuronidation (GO:0052695)	3.16791945
76	epoxygenase P450 pathway (GO:0019373)	3.06954930
77	bile acid and bile salt transport (GO:0015721)	3.06885394
78	translational initiation (GO:0006413)	3.01866708
79	drug metabolic process (GO:0017144)	3.01638953
80	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.00542217
81	protein complex disassembly (GO:0043241)	2.98572029
82	cellular component maintenance (GO:0043954)	2.98441987
83	ubiquinone metabolic process (GO:0006743)	2.98055785
84	regulation of cholesterol esterification (GO:0010872)	2.98004573
85	chaperone-mediated protein complex assembly (GO:0051131)	2.97796016
86	alpha-amino acid catabolic process (GO:1901606)	2.96816638
87	negative regulation of cholesterol transport (GO:0032375)	2.92877244
88	negative regulation of sterol transport (GO:0032372)	2.92877244
89	chromosome organization involved in meiosis (GO:0070192)	2.91922939
90	glycerophospholipid catabolic process (GO:0046475)	2.88508504
91	steroid catabolic process (GO:0006706)	2.87377144
92	negative regulation of astrocyte differentiation (GO:0048712)	2.87340375
93	cellular aldehyde metabolic process (GO:0006081)	2.87134348
94	quinone biosynthetic process (GO:1901663)	2.85861994
95	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.84504818
96	complement activation, alternative pathway (GO:0006957)	2.83693464
97	cellular amino acid catabolic process (GO:0009063)	2.83335852
98	protein targeting to membrane (GO:0006612)	2.82908889
99	drug transmembrane transport (GO:0006855)	2.82714747
100	alkaloid metabolic process (GO:0009820)	2.77705787

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	4.75635186
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.90841966
3	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.45077121
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.05801221
5	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.90937912
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.84349720
7	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.83734082
8	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.82441036
9	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.76828904
10	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.74264822
11	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	2.70081444
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.67420125
13	RXR_22158963_ChIP-Seq_LIVER_Mouse	2.59355139
14	EZH2_22144423_ChIP-Seq_EOC_Human	2.57282730
15	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53653213
16	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.39201223
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33420559
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.32054643
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.25563106
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.10408901
21	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.07590973
22	PPARA_22158963_ChIP-Seq_LIVER_Mouse	2.00339655
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.88743737
24	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.86552349
25	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.84232880
26	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.81909408
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.76167492
28	TTF2_22483619_ChIP-Seq_HELA_Human	1.72681040
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67966643
30	GABP_19822575_ChIP-Seq_HepG2_Human	1.67313411
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.66133997
32	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.64759590
33	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.63635383
34	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.59442967
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.57069841
36	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.54950544
37	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.44244062
38	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40229886
39	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.39328150
40	ZNF274_21170338_ChIP-Seq_K562_Hela	1.37316187
41	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.34278813
42	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.33556195
43	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.30974521
44	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.28051948
45	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.26680736
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26325863
47	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.26320484
48	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.22665054
49	XRN2_22483619_ChIP-Seq_HELA_Human	1.22584308
50	ZNF263_19887448_ChIP-Seq_K562_Human	1.18504800
51	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.13879207
52	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	1.13330017
53	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.12772646
54	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.11724987
55	KAP1_22055183_ChIP-Seq_ESCs_Mouse	1.10495505
56	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.08654761
57	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.07723221
58	HNF4A_19822575_ChIP-Seq_HepG2_Human	1.07506620
59	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.07309957
60	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.06815566
61	MYC_18940864_ChIP-ChIP_HL60_Human	1.05322254
62	CTCF_20526341_ChIP-Seq_ESCs_Human	1.05092857
63	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.03615735
64	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.03590000
65	PHF8_20622853_ChIP-Seq_HELA_Human	1.03472425
66	ERA_21632823_ChIP-Seq_H3396_Human	1.03051032
67	E2F7_22180533_ChIP-Seq_HELA_Human	1.02087789
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.01085535
69	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.00544911
70	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.00109090
71	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.99845224
72	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.96816938
73	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.96816938
74	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.96816938
75	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.96354265
76	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.95795462
77	AR_21909140_ChIP-Seq_LNCAP_Human	0.95355821
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.94249240
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.93463408
80	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.92997107
81	AR_20517297_ChIP-Seq_VCAP_Human	0.91743734
82	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.90872552
83	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87664635
84	FOXP3_21729870_ChIP-Seq_TREG_Human	0.87488994
85	ETV1_20927104_ChIP-Seq_GIST48_Human	0.86908848
86	CTCF_27219007_Chip-Seq_Bcells_Human	0.86695138
87	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.85986739
88	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.85754665
89	NCOR_22424771_ChIP-Seq_293T_Human	0.85616362
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.84699216
91	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.84658821
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.84133919
93	RXRA_24833708_ChIP-Seq_LIVER_Mouse	0.83252104
94	GATA3_21867929_ChIP-Seq_CD8_Mouse	0.83091544
95	ELK1_19687146_ChIP-ChIP_HELA_Human	0.82706852
96	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.82514402
97	PRDM5_23873026_ChIP-Seq_MEFs_Mouse	0.82302184
98	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.82104250
99	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.82077873
100	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.81822830

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	5.91580719
2	MP0009379_abnormal_foot_pigmentation	4.82356259
3	MP0005360_urolithiasis	4.44473218
4	MP0002138_abnormal_hepatobiliary_system	3.98839894
5	MP0006292_abnormal_olfactory_placode	3.92474358
6	MP0005085_abnormal_gallbladder_physiolo	3.56207652
7	MP0009697_abnormal_copulation	3.20531018
8	MP0005365_abnormal_bile_salt	3.16317382
9	MP0003195_calcinosis	3.15551787
10	MP0003868_abnormal_feces_composition	3.13488422
11	MP0008875_abnormal_xenobiotic_pharmacok	2.82313439
12	MP0002876_abnormal_thyroid_physiology	2.69089894
13	MP0003186_abnormal_redox_activity	2.57719329
14	MP0002653_abnormal_ependyma_morphology	2.39391945
15	MP0005408_hypopigmentation	2.06526575
16	MP0001529_abnormal_vocalization	2.06485627
17	MP0003122_maternal_imprinting	2.00030789
18	MP0003646_muscle_fatigue	1.89789089
19	MP0003252_abnormal_bile_duct	1.89200258
20	MP0003806_abnormal_nucleotide_metabolis	1.88606723
21	MP0001666_abnormal_nutrient_absorption	1.82070461
22	MP0003136_yellow_coat_color	1.79519826
23	MP0008789_abnormal_olfactory_epithelium	1.73319199
24	MP0008877_abnormal_DNA_methylation	1.72944098
25	MP0000566_synostosis	1.64312203
26	MP0010030_abnormal_orbit_morphology	1.63128398
27	MP0004147_increased_porphyrin_level	1.61938775
28	MP0005332_abnormal_amino_acid	1.61279518
29	MP0001764_abnormal_homeostasis	1.57910171
30	MP0010329_abnormal_lipoprotein_level	1.54957814
31	MP0002938_white_spotting	1.44964533
32	MP0005499_abnormal_olfactory_system	1.44028464
33	MP0005394_taste/olfaction_phenotype	1.44028464
34	MP0010368_abnormal_lymphatic_system	1.41104141
35	MP0006036_abnormal_mitochondrial_physio	1.37521865
36	MP0004019_abnormal_vitamin_homeostasis	1.34980238
37	MP0000049_abnormal_middle_ear	1.27973479
38	MP0009840_abnormal_foam_cell	1.24564875
39	MP0006035_abnormal_mitochondrial_morpho	1.22195075
40	MP0003718_maternal_effect	1.20910298
41	MP0008058_abnormal_DNA_repair	1.18299243
42	MP0001929_abnormal_gametogenesis	1.17936026
43	MP0002210_abnormal_sex_determination	1.17443839
44	MP0001324_abnormal_eye_pigmentation	1.16973658
45	MP0004142_abnormal_muscle_tone	1.13689744
46	MP0002160_abnormal_reproductive_system	1.11816059
47	MP0003121_genomic_imprinting	1.10382188
48	MP0001984_abnormal_olfaction	1.06070520
49	MP0003698_abnormal_male_reproductive	1.03748691
50	MP0003959_abnormal_lean_body	1.03195178
51	MP0001986_abnormal_taste_sensitivity	0.99685780
52	MP0002249_abnormal_larynx_morphology	0.99622872
53	MP0002118_abnormal_lipid_homeostasis	0.97753484
54	MP0002132_abnormal_respiratory_system	0.94340214
55	MP0003879_abnormal_hair_cell	0.93457083
56	MP0002837_dystrophic_cardiac_calcinosis	0.87685046
57	MP0005423_abnormal_somatic_nervous	0.85224864
58	MP0001293_anophthalmia	0.85000534
59	MP0003693_abnormal_embryo_hatching	0.84466331
60	MP0001915_intracranial_hemorrhage	0.83336544
61	MP0002233_abnormal_nose_morphology	0.81405657
62	MP0008932_abnormal_embryonic_tissue	0.80007998
63	MP0001661_extended_life_span	0.78815733
64	MP0000653_abnormal_sex_gland	0.78530157
65	MP0003011_delayed_dark_adaptation	0.77975891
66	MP0002090_abnormal_vision	0.77671166
67	MP0010094_abnormal_chromosome_stability	0.77565202
68	MP0002161_abnormal_fertility/fecundity	0.77213912
69	MP0001145_abnormal_male_reproductive	0.76922645
70	MP0005187_abnormal_penis_morphology	0.74395606
71	MP0005319_abnormal_enzyme/_coenzyme	0.73344755
72	MP0005389_reproductive_system_phenotype	0.73080830
73	MP0005174_abnormal_tail_pigmentation	0.72667652
74	MP0000778_abnormal_nervous_system	0.72429001
75	MP0005670_abnormal_white_adipose	0.71959361
76	MP0002282_abnormal_trachea_morphology	0.71937696
77	MP0003123_paternal_imprinting	0.71612069
78	MP0009384_cardiac_valve_regurgitation	0.68280546
79	MP0005551_abnormal_eye_electrophysiolog	0.67619561
80	MP0000026_abnormal_inner_ear	0.67012320
81	MP0002127_abnormal_cardiovascular_syste	0.66175141
82	MP0005197_abnormal_uvea_morphology	0.65663592
83	MP0005195_abnormal_posterior_eye	0.65430897
84	MP0005410_abnormal_fertilization	0.64546945
85	MP0005636_abnormal_mineral_homeostasis	0.64184652
86	MP0005584_abnormal_enzyme/coenzyme_acti	0.63338966
87	MP0002822_catalepsy	0.62242069
88	MP0002638_abnormal_pupillary_reflex	0.60932854
89	MP0004885_abnormal_endolymph	0.59032292
90	MP0003937_abnormal_limbs/digits/tail_de	0.58710264
91	MP0000609_abnormal_liver_physiology	0.58156686
92	MP0002697_abnormal_eye_size	0.57915859
93	MP0002735_abnormal_chemical_nociception	0.57778976
94	MP0009053_abnormal_anal_canal	0.56699034
95	MP0004957_abnormal_blastocyst_morpholog	0.56474107
96	MP0008260_abnormal_autophagy	0.55158376
97	MP0001963_abnormal_hearing_physiology	0.54382960
98	MP0004233_abnormal_muscle_weight	0.54132033
99	MP0003755_abnormal_palate_morphology	0.53388461
100	MP0009046_muscle_twitch	0.53279743

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Deep venous thrombosis (HP:0002625)	6.53365882
2	Reticulocytopenia (HP:0001896)	5.74541164
3	Abnormality of monocarboxylic acid metabolism (HP:0010996)	5.21388768
4	Hypobetalipoproteinemia (HP:0003563)	4.94149293
5	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.69786788
6	Abnormality of pyrimidine metabolism (HP:0004353)	4.57742093
7	Prolonged partial thromboplastin time (HP:0003645)	4.36695102
8	Reduced antithrombin III activity (HP:0001976)	3.58561636
9	Osteomalacia (HP:0002749)	3.37936163
10	Hyperlipoproteinemia (HP:0010980)	3.25077238
11	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.22621859
12	Intrahepatic cholestasis (HP:0001406)	3.12909571
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.11459167
14	Hyperglycinemia (HP:0002154)	2.98984373
15	Birth length less than 3rd percentile (HP:0003561)	2.94487350
16	Ragged-red muscle fibers (HP:0003200)	2.76685997
17	Bile duct proliferation (HP:0001408)	2.75278034
18	Abnormal biliary tract physiology (HP:0012439)	2.75278034
19	Increased serum pyruvate (HP:0003542)	2.74051829
20	Septo-optic dysplasia (HP:0100842)	2.70683098
21	Microvesicular hepatic steatosis (HP:0001414)	2.70092286
22	Macrocytic anemia (HP:0001972)	2.67334772
23	Cerebral edema (HP:0002181)	2.64532879
24	Hypolipoproteinemia (HP:0010981)	2.63976574
25	Acute encephalopathy (HP:0006846)	2.62757746
26	Xanthomatosis (HP:0000991)	2.62171429
27	Glycosuria (HP:0003076)	2.49260569
28	Abnormality of urine glucose concentration (HP:0011016)	2.49260569
29	Abnormal respiratory motile cilium physiology (HP:0012261)	2.46017074
30	Generalized aminoaciduria (HP:0002909)	2.42574964
31	Abnormality of reticulocytes (HP:0004312)	2.41217281
32	Acute necrotizing encephalopathy (HP:0006965)	2.40992185
33	Abnormality of nucleobase metabolism (HP:0010932)	2.40202955
34	Breast hypoplasia (HP:0003187)	2.33992869
35	Abnormal mitochondria in muscle tissue (HP:0008316)	2.33609588
36	Stenosis of the external auditory canal (HP:0000402)	2.31881216
37	Hyperammonemia (HP:0001987)	2.30069381
38	Morphological abnormality of the pyramidal tract (HP:0002062)	2.29818135
39	Scanning speech (HP:0002168)	2.28830722
40	Impulsivity (HP:0100710)	2.23899784
41	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.22895602
42	Metabolic acidosis (HP:0001942)	2.22480228
43	Cholecystitis (HP:0001082)	2.22086126
44	Abnormal gallbladder physiology (HP:0012438)	2.22086126
45	Hyperphosphaturia (HP:0003109)	2.20838783
46	Pallor (HP:0000980)	2.20086560
47	Abnormal number of erythroid precursors (HP:0012131)	2.18138154
48	Systemic lupus erythematosus (HP:0002725)	2.17097643
49	Sensorimotor neuropathy (HP:0007141)	2.13355084
50	Abnormality of glycolysis (HP:0004366)	2.13134508
51	Hepatocellular necrosis (HP:0001404)	2.13125039
52	Type II lissencephaly (HP:0007260)	2.12125002
53	Hepatic necrosis (HP:0002605)	2.11156102
54	Abnormal ciliary motility (HP:0012262)	2.11097987
55	Absent thumb (HP:0009777)	2.10587628
56	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.08694395
57	Hypoplasia of the radius (HP:0002984)	2.08495239
58	Long foot (HP:0001833)	2.05303546
59	Short tibia (HP:0005736)	2.05227750
60	Mitochondrial inheritance (HP:0001427)	2.03518484
61	Joint hemorrhage (HP:0005261)	2.03083328
62	Lethargy (HP:0001254)	2.02632531
63	Fibular hypoplasia (HP:0003038)	1.97568307
64	Complement deficiency (HP:0004431)	1.95759106
65	Colon cancer (HP:0003003)	1.95723124
66	Rhinitis (HP:0012384)	1.95007911
67	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.94803359
68	Papilledema (HP:0001085)	1.94048615
69	Hip dysplasia (HP:0001385)	1.92865361
70	Delayed CNS myelination (HP:0002188)	1.89973438
71	Increased CSF lactate (HP:0002490)	1.88502004
72	Absent septum pellucidum (HP:0001331)	1.88202327
73	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87725062
74	Abnormality of glycine metabolism (HP:0010895)	1.87725062
75	Abnormal urine phosphate concentration (HP:0012599)	1.85667739
76	Polyphagia (HP:0002591)	1.83542902
77	Myokymia (HP:0002411)	1.80871418
78	Abnormality of serum amino acid levels (HP:0003112)	1.79749955
79	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.79303322
80	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.79303322
81	Prolonged neonatal jaundice (HP:0006579)	1.79223711
82	Horseshoe kidney (HP:0000085)	1.79017587
83	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.77339829
84	Vaginal fistula (HP:0004320)	1.77309625
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.76488830
86	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.75156790
87	Irritability (HP:0000737)	1.74643438
88	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.73238000
89	Nasal speech (HP:0001611)	1.72672571
90	Absent/shortened dynein arms (HP:0200106)	1.69725470
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69725470
92	Abnormality of carpal bone ossification (HP:0006257)	1.69432325
93	Progressive macrocephaly (HP:0004481)	1.69023002
94	Increased serum lactate (HP:0002151)	1.67070046
95	Optic nerve hypoplasia (HP:0000609)	1.67005352
96	Tubulointerstitial nephritis (HP:0001970)	1.66906503
97	Slender long bone (HP:0003100)	1.66276101
98	Rickets (HP:0002748)	1.64579082
99	Short femoral neck (HP:0100864)	1.64369391
100	Partial duplication of thumb phalanx (HP:0009944)	1.64323351

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDC7	5.16199235
2	CDK19	2.84294882
3	NTRK1	2.83632032
4	PLK4	2.79253361
5	STK16	2.77538831
6	LIMK1	2.69403462
7	EPHB2	2.63267311
8	PIK3CG	2.46048161
9	DYRK2	2.43560448
10	NTRK2	2.32956474
11	MAP3K11	2.30216173
12	BCKDK	2.23581902
13	PLK1	2.03771118
14	PDK2	1.87895124
15	LRRK2	1.78919949
16	BCR	1.65473705
17	BRSK1	1.57633839
18	NEK2	1.54114814
19	VRK2	1.53729954
20	STK11	1.49839667
21	BRAF	1.49147833
22	AURKA	1.48011247
23	PINK1	1.34907896
24	PIK3CA	1.28524914
25	PTK2B	1.27675999
26	TTK	1.24753127
27	PLK2	1.23959971
28	PRKCG	1.21776251
29	ABL2	1.18986915
30	MAP3K12	1.14952129
31	KDR	1.14329692
32	NME1	1.13499899
33	TESK2	1.12725327
34	EPHA4	1.09680796
35	MUSK	1.09417532
36	WNK4	1.07101513
37	WEE1	1.05121788
38	WNK3	1.03786358
39	NEK1	1.03608353
40	GRK1	0.98117275
41	ACVR1B	0.97917478
42	PNCK	0.96920817
43	AURKB	0.96354488
44	CSNK1G2	0.91645103
45	MYLK	0.91372823
46	TRIM28	0.87297429
47	PRKCZ	0.85973596
48	PBK	0.79893092
49	NTRK3	0.79152183
50	MAPK15	0.78494709
51	LATS2	0.78079841
52	VRK1	0.75270121
53	CHEK1	0.73554513
54	CSNK2A1	0.73347155
55	CSNK1G3	0.73069469
56	BMPR1B	0.72088816
57	CDK9	0.71226383
58	RPS6KB1	0.71179174
59	BUB1	0.70497016
60	CDK11A	0.70186664
61	CSNK2A2	0.70171417
62	CDK14	0.66951779
63	PRKACA	0.66108349
64	CDK15	0.64985277
65	CHEK2	0.64674718
66	CSNK1E	0.64089624
67	ATR	0.63529839
68	PLK3	0.62029316
69	SRPK1	0.61949633
70	PIM2	0.59859827
71	CDK8	0.59703348
72	PRKACG	0.58848882
73	STK39	0.57941573
74	MARK1	0.56851863
75	DYRK3	0.56820406
76	CSNK1G1	0.56314050
77	CDK18	0.54689918
78	CSNK1A1L	0.54303347
79	DAPK3	0.52555279
80	NUAK1	0.51863946
81	MAP3K4	0.51860092
82	ATM	0.50808144
83	DYRK1B	0.49467673
84	ZAK	0.48278924
85	OXSR1	0.45295047
86	SGK494	0.44844409
87	SGK223	0.44844409
88	DYRK1A	0.44291300
89	PKN1	0.44287947
90	DMPK	0.42843969
91	PASK	0.42652235
92	CSNK1D	0.41539873
93	AKT2	0.39296298
94	PRKACB	0.39101424
95	PRKCI	0.38915932
96	MAPK11	0.38677982
97	CDK1	0.36668525
98	SGK1	0.36000551
99	STK38L	0.34869002
100	MAP2K4	0.34031902

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	3.75547724
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.49572769
3	Ribosome_Homo sapiens_hsa03010	3.17282142
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95631235
5	Sulfur relay system_Homo sapiens_hsa04122	2.68230156
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.55369442
7	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.42884615
8	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.34912104
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.24985761
10	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.18083095
11	Phenylalanine metabolism_Homo sapiens_hsa00360	2.17254469
12	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.16330340
13	Retinol metabolism_Homo sapiens_hsa00830	2.16020847
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.05176474
15	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.04786492
16	Chemical carcinogenesis_Homo sapiens_hsa05204	2.00318908
17	Peroxisome_Homo sapiens_hsa04146	1.99363617
18	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.92243177
19	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.91681434
20	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.85383885
21	Arginine biosynthesis_Homo sapiens_hsa00220	1.82334454
22	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.82209043
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.72523375
24	beta-Alanine metabolism_Homo sapiens_hsa00410	1.72273252
25	Steroid biosynthesis_Homo sapiens_hsa00100	1.70140766
26	Fatty acid degradation_Homo sapiens_hsa00071	1.63794844
27	Propanoate metabolism_Homo sapiens_hsa00640	1.62632658
28	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.59877420
29	Folate biosynthesis_Homo sapiens_hsa00790	1.58791967
30	Homologous recombination_Homo sapiens_hsa03440	1.56614747
31	Arginine and proline metabolism_Homo sapiens_hsa00330	1.48330227
32	Oxidative phosphorylation_Homo sapiens_hsa00190	1.47777363
33	Bile secretion_Homo sapiens_hsa04976	1.42561177
34	Fatty acid elongation_Homo sapiens_hsa00062	1.41214807
35	Pyruvate metabolism_Homo sapiens_hsa00620	1.40528949
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.37014853
37	Parkinsons disease_Homo sapiens_hsa05012	1.33215282
38	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.33003348
39	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.28348521
40	Huntingtons disease_Homo sapiens_hsa05016	1.24521261
41	Butanoate metabolism_Homo sapiens_hsa00650	1.23857489
42	Mismatch repair_Homo sapiens_hsa03430	1.21009526
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.16862650
44	Sulfur metabolism_Homo sapiens_hsa00920	1.16055269
45	Linoleic acid metabolism_Homo sapiens_hsa00591	1.14731380
46	Caffeine metabolism_Homo sapiens_hsa00232	1.14448100
47	Fanconi anemia pathway_Homo sapiens_hsa03460	1.12324588
48	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.08139462
49	Tryptophan metabolism_Homo sapiens_hsa00380	1.05870072
50	Tyrosine metabolism_Homo sapiens_hsa00350	1.02090256
51	DNA replication_Homo sapiens_hsa03030	0.99156903
52	Carbon metabolism_Homo sapiens_hsa01200	0.98133177
53	PPAR signaling pathway_Homo sapiens_hsa03320	0.95124334
54	Fatty acid metabolism_Homo sapiens_hsa01212	0.95015051
55	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.93338555
56	Base excision repair_Homo sapiens_hsa03410	0.91405309
57	Histidine metabolism_Homo sapiens_hsa00340	0.90568778
58	RNA polymerase_Homo sapiens_hsa03020	0.90033544
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.86050147
60	Pyrimidine metabolism_Homo sapiens_hsa00240	0.83850404
61	Nitrogen metabolism_Homo sapiens_hsa00910	0.80978624
62	Metabolic pathways_Homo sapiens_hsa01100	0.78432820
63	Alzheimers disease_Homo sapiens_hsa05010	0.77232637
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.75880001
65	Cardiac muscle contraction_Homo sapiens_hsa04260	0.73290700
66	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.72435663
67	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.72233247
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72092804
69	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72016066
70	Glutathione metabolism_Homo sapiens_hsa00480	0.70750866
71	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.70609138
72	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.67735688
73	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.62359449
74	One carbon pool by folate_Homo sapiens_hsa00670	0.59733830
75	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57009683
76	Nucleotide excision repair_Homo sapiens_hsa03420	0.55874678
77	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.52396497
78	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50873115
79	Lysine degradation_Homo sapiens_hsa00310	0.48249302
80	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.46607237
81	RNA transport_Homo sapiens_hsa03013	0.41923459
82	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.40601695
83	Protein export_Homo sapiens_hsa03060	0.40133855
84	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.28261960
85	Regulation of autophagy_Homo sapiens_hsa04140	0.27860669
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.27472439
87	Spliceosome_Homo sapiens_hsa03040	0.26503162
88	ABC transporters_Homo sapiens_hsa02010	0.25526312
89	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.25509777
90	Proteasome_Homo sapiens_hsa03050	0.25018389
91	Purine metabolism_Homo sapiens_hsa00230	0.23975829
92	Basal transcription factors_Homo sapiens_hsa03022	0.21745742
93	RNA degradation_Homo sapiens_hsa03018	0.18782791
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18558961
95	Hippo signaling pathway_Homo sapiens_hsa04390	0.18077656
96	Galactose metabolism_Homo sapiens_hsa00052	0.16490217
97	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.14976894
98	Basal cell carcinoma_Homo sapiens_hsa05217	0.08123275
99	Tight junction_Homo sapiens_hsa04530	0.07355034
100	Oocyte meiosis_Homo sapiens_hsa04114	0.06843323

RPL39P40

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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