RPL39P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sleep (GO:0030431)5.41177370
2ATP synthesis coupled proton transport (GO:0015986)5.09581410
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.09581410
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98309116
5tolerance induction (GO:0002507)4.69634044
6negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.69320788
7regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.35209515
8regulation of memory T cell differentiation (GO:0043380)4.34667576
9ribosomal small subunit assembly (GO:0000028)4.29236199
10cellular response to interleukin-15 (GO:0071350)4.16537346
11viral transcription (GO:0019083)4.12826347
12positive regulation of defense response to virus by host (GO:0002230)4.06633647
13positive regulation of T cell mediated cytotoxicity (GO:0001916)4.05804604
14DNA deamination (GO:0045006)3.98106461
15regulation of T cell mediated cytotoxicity (GO:0001914)3.97850692
16translational termination (GO:0006415)3.95608161
17sequestering of actin monomers (GO:0042989)3.87261869
18negative regulation of DNA-templated transcription, elongation (GO:0032785)3.79285899
19negative regulation of cell killing (GO:0031342)3.69587474
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.69587474
21mast cell activation (GO:0045576)3.68105344
22negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.67513151
23behavioral response to nicotine (GO:0035095)3.65305826
24preassembly of GPI anchor in ER membrane (GO:0016254)3.65069909
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.62477270
26cotranslational protein targeting to membrane (GO:0006613)3.59291553
27protein targeting to ER (GO:0045047)3.55586172
28tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46835175
29RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46835175
30protein localization to endoplasmic reticulum (GO:0070972)3.45581800
31response to gravity (GO:0009629)3.45460086
32translational elongation (GO:0006414)3.41364653
33positive regulation of T-helper 1 type immune response (GO:0002827)3.39778940
34establishment of protein localization to endoplasmic reticulum (GO:0072599)3.38788929
35regulation of mitotic spindle checkpoint (GO:1903504)3.33394573
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33394573
37protein complex biogenesis (GO:0070271)3.32680678
38chaperone-mediated protein transport (GO:0072321)3.28450488
39positive regulation of T cell differentiation in thymus (GO:0033089)3.27442949
40regulation of regulatory T cell differentiation (GO:0045589)3.26797902
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23740370
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20217926
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.20217926
44NADH dehydrogenase complex assembly (GO:0010257)3.20217926
45establishment of protein localization to mitochondrial membrane (GO:0090151)3.16418929
46regulation of defense response to virus by host (GO:0050691)3.16277770
47mast cell activation involved in immune response (GO:0002279)3.15415606
48mast cell degranulation (GO:0043303)3.15415606
49RNA destabilization (GO:0050779)3.14598950
50mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.14470727
51regulation of chronic inflammatory response (GO:0002676)3.13803002
52protein neddylation (GO:0045116)3.11481164
53regulation of leukocyte mediated cytotoxicity (GO:0001910)3.10610531
54mitochondrial respiratory chain complex assembly (GO:0033108)3.09672139
55response to interleukin-15 (GO:0070672)3.07726838
56somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07264504
57isotype switching (GO:0045190)3.07264504
58somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07264504
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.06221457
60regulation of germinal center formation (GO:0002634)3.02683929
61viral life cycle (GO:0019058)3.02480181
62GPI anchor biosynthetic process (GO:0006506)3.02471953
63positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.02333035
64mannosylation (GO:0097502)3.01699570
65GPI anchor metabolic process (GO:0006505)2.98055331
66positive regulation of T cell mediated immunity (GO:0002711)2.97058227
67electron transport chain (GO:0022900)2.93305962
68ATP biosynthetic process (GO:0006754)2.93179683
69positive regulation of cell fate commitment (GO:0010455)2.93026428
70regulation of T-helper 1 type immune response (GO:0002825)2.91318740
71regulation of cell killing (GO:0031341)2.90164671
72cellular protein complex disassembly (GO:0043624)2.89899269
73positive regulation of alpha-beta T cell proliferation (GO:0046641)2.89638899
74respiratory electron transport chain (GO:0022904)2.89549551
75regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.88435849
76adenosine metabolic process (GO:0046085)2.88388099
77endoderm formation (GO:0001706)2.85668313
78detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.84340496
79platelet dense granule organization (GO:0060155)2.81805662
80positive regulation of cell killing (GO:0031343)2.75762868
81piRNA metabolic process (GO:0034587)2.75555133
82ribosomal large subunit biogenesis (GO:0042273)2.75394222
83positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.75348894
84positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.72791353
85purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.69812863
86purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68716853
87response to interferon-beta (GO:0035456)2.68036562
88cellular response to exogenous dsRNA (GO:0071360)2.66128413
89negative regulation of interleukin-1 beta production (GO:0032691)2.66099477
90positive regulation of oligodendrocyte differentiation (GO:0048714)2.65711622
91translational initiation (GO:0006413)2.64444957
92positive regulation of mRNA catabolic process (GO:0061014)2.62404668
93dendritic cell chemotaxis (GO:0002407)2.62239070
94nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.59693130
95protein-cofactor linkage (GO:0018065)2.59206316
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.56925340
97positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.56815024
98regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.56815024
99regulation of T cell mediated immunity (GO:0002709)2.56299637
100interferon-gamma production (GO:0032609)2.54297224

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.32538911
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.68031622
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.60441270
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.43310060
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.40677749
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.37145237
7VDR_22108803_ChIP-Seq_LS180_Human2.97918221
8NOTCH1_21737748_ChIP-Seq_TLL_Human2.87622547
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.83359100
10VDR_23849224_ChIP-Seq_CD4+_Human2.58957995
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.51167504
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49321266
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.43472743
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.40499075
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.35119382
16ZNF274_21170338_ChIP-Seq_K562_Hela2.32321917
17ELK1_19687146_ChIP-ChIP_HELA_Human2.20850397
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18369024
19FLI1_27457419_Chip-Seq_LIVER_Mouse2.18247539
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.17690829
21MYC_18940864_ChIP-ChIP_HL60_Human2.15929035
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.12910793
23RUNX_20019798_ChIP-Seq_JUKART_Human2.11886065
24GATA3_26560356_Chip-Seq_TH2_Human1.98835553
25FOXP3_21729870_ChIP-Seq_TREG_Human1.91679788
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.86194332
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84608306
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82830843
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.79058699
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69303517
31MYB_26560356_Chip-Seq_TH2_Human1.66099766
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59822830
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58716832
34IRF1_19129219_ChIP-ChIP_H3396_Human1.55105267
35TP53_22573176_ChIP-Seq_HFKS_Human1.53666334
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.50550470
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43878992
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43389967
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40581151
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38437646
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37850136
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37113445
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36299948
44FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35659646
45FOXA1_25329375_ChIP-Seq_VCAP_Human1.35659646
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34779208
47AR_20517297_ChIP-Seq_VCAP_Human1.33576178
48FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.32635780
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31264294
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.29751855
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.29685114
52TTF2_22483619_ChIP-Seq_HELA_Human1.28658367
53GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26112021
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.24904579
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22200664
56EZH2_22144423_ChIP-Seq_EOC_Human1.18556891
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18213363
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.17797174
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17676282
60TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16091176
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14733647
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14257719
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14199635
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.13188173
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.13141075
66RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.12100639
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12010939
68PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10249597
69FUS_26573619_Chip-Seq_HEK293_Human1.09480202
70TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09037540
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08362727
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.07273770
73EWS_26573619_Chip-Seq_HEK293_Human1.07029779
74TAF15_26573619_Chip-Seq_HEK293_Human1.06065060
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05836718
76GATA3_27048872_Chip-Seq_THYMUS_Human1.05612328
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.04267802
78SOX2_19829295_ChIP-Seq_ESCs_Human1.03359369
79NANOG_19829295_ChIP-Seq_ESCs_Human1.03359369
80FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02726904
81FOXH1_21741376_ChIP-Seq_EPCs_Human1.01930319
82FOXA1_21572438_ChIP-Seq_LNCaP_Human1.01735269
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01159214
84STAT1_20625510_ChIP-Seq_HELA_Human0.99632248
85ERG_20517297_ChIP-Seq_VCAP_Human0.99349200
86NANOG_20526341_ChIP-Seq_ESCs_Human0.99072832
87HOXB7_26014856_ChIP-Seq_BT474_Human0.98789782
88MYC_18555785_ChIP-Seq_MESCs_Mouse0.97549565
89P300_19829295_ChIP-Seq_ESCs_Human0.97187421
90IRF8_21731497_ChIP-ChIP_J774_Mouse0.96703352
91CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95781794
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95548420
93XRN2_22483619_ChIP-Seq_HELA_Human0.94616360
94SUZ12_27294783_Chip-Seq_NPCs_Mouse0.94507244
95ERA_21632823_ChIP-Seq_H3396_Human0.92464701
96TAF2_19829295_ChIP-Seq_ESCs_Human0.91702230
97NCOR_22424771_ChIP-Seq_293T_Human0.88877592
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88549185
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.87089197
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86659154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.08969996
2MP0002876_abnormal_thyroid_physiology2.93540848
3MP0006072_abnormal_retinal_apoptosis2.89348808
4MP0009379_abnormal_foot_pigmentation2.58779758
5MP0003724_increased_susceptibility_to2.55898098
6MP0003436_decreased_susceptibility_to2.40079547
7MP0003763_abnormal_thymus_physiology2.36247229
8MP0003195_calcinosis2.35775716
9MP0001835_abnormal_antigen_presentation2.18224378
10MP0001986_abnormal_taste_sensitivity2.15712160
11MP0005000_abnormal_immune_tolerance2.15565797
12MP0008875_abnormal_xenobiotic_pharmacok2.06946865
13MP0004147_increased_porphyrin_level2.06195166
14MP0000685_abnormal_immune_system2.03815377
15MP0004885_abnormal_endolymph1.96234928
16MP0000465_gastrointestinal_hemorrhage1.96190371
17MP0008872_abnormal_physiological_respon1.90467479
18MP0001800_abnormal_humoral_immune1.89084291
19MP0002736_abnormal_nociception_after1.82863868
20MP0002277_abnormal_respiratory_mucosa1.78955613
21MP0002148_abnormal_hypersensitivity_rea1.76552747
22MP0008877_abnormal_DNA_methylation1.69332027
23MP0002723_abnormal_immune_serum1.66950188
24MP0005253_abnormal_eye_physiology1.65518078
25MP0001968_abnormal_touch/_nociception1.64639313
26MP0002933_joint_inflammation1.61653074
27MP0003866_abnormal_defecation1.58614967
28MP0005645_abnormal_hypothalamus_physiol1.57710445
29MP0005551_abnormal_eye_electrophysiolog1.57018146
30MP0001501_abnormal_sleep_pattern1.55232649
31MP0009785_altered_susceptibility_to1.53170637
32MP0001533_abnormal_skeleton_physiology1.51912133
33MP0009764_decreased_sensitivity_to1.51095052
34MP0001919_abnormal_reproductive_system1.49848233
35MP0002938_white_spotting1.49325127
36MP0002102_abnormal_ear_morphology1.49184622
37MP0003011_delayed_dark_adaptation1.48377830
38MP0001873_stomach_inflammation1.45199485
39MP0002452_abnormal_antigen_presenting1.44706118
40MP0001819_abnormal_immune_cell1.43294605
41MP0002420_abnormal_adaptive_immunity1.40827371
42MP0003878_abnormal_ear_physiology1.40342605
43MP0005377_hearing/vestibular/ear_phenot1.40342605
44MP0003638_abnormal_response/metabolism_1.38799747
45MP0004133_heterotaxia1.35036064
46MP0000372_irregular_coat_pigmentation1.31593903
47MP0005084_abnormal_gallbladder_morpholo1.28604731
48MP0009333_abnormal_splenocyte_physiolog1.22597925
49MP0005360_urolithiasis1.21304639
50MP0004742_abnormal_vestibular_system1.21280282
51MP0005387_immune_system_phenotype1.20612038
52MP0001790_abnormal_immune_system1.20612038
53MP0005389_reproductive_system_phenotype1.20538225
54MP0003786_premature_aging1.19243598
55MP0002009_preneoplasia1.19038853
56MP0002653_abnormal_ependyma_morphology1.14588887
57MP0003806_abnormal_nucleotide_metabolis1.13310787
58MP0008058_abnormal_DNA_repair1.13292192
59MP0002166_altered_tumor_susceptibility1.12722359
60MP0008775_abnormal_heart_ventricle1.12537489
61MP0006292_abnormal_olfactory_placode1.11726237
62MP0002405_respiratory_system_inflammati1.09961735
63MP0008995_early_reproductive_senescence1.08424388
64MP0002006_tumorigenesis1.07566180
65MP0005075_abnormal_melanosome_morpholog1.07437661
66MP0003186_abnormal_redox_activity1.07170039
67MP0000716_abnormal_immune_system1.05270250
68MP0009745_abnormal_behavioral_response1.05035133
69MP0001845_abnormal_inflammatory_respons1.05025570
70MP0005025_abnormal_response_to1.03713265
71MP0010155_abnormal_intestine_physiology1.01510058
72MP0000689_abnormal_spleen_morphology0.99762960
73MP0001905_abnormal_dopamine_level0.98930890
74MP0002272_abnormal_nervous_system0.96946190
75MP0002398_abnormal_bone_marrow0.96685399
76MP0000703_abnormal_thymus_morphology0.94447841
77MP0004142_abnormal_muscle_tone0.93037109
78MP0005646_abnormal_pituitary_gland0.91989963
79MP0002722_abnormal_immune_system0.88703270
80MP0002419_abnormal_innate_immunity0.86883684
81MP0005390_skeleton_phenotype0.86188235
82MP0008789_abnormal_olfactory_epithelium0.82143980
83MP0001765_abnormal_ion_homeostasis0.81112009
84MP0003315_abnormal_perineum_morphology0.79497074
85MP0001542_abnormal_bone_strength0.79372924
86MP0001851_eye_inflammation0.78590637
87MP0002928_abnormal_bile_duct0.76395968
88MP0002429_abnormal_blood_cell0.75470035
89MP0000427_abnormal_hair_cycle0.75467100
90MP0002837_dystrophic_cardiac_calcinosis0.74412841
91MP0005310_abnormal_salivary_gland0.70824764
92MP0005332_abnormal_amino_acid0.70292203
93MP0001346_abnormal_lacrimal_gland0.69607943
94MP0003136_yellow_coat_color0.69402145
95MP0002138_abnormal_hepatobiliary_system0.69170724
96MP0001502_abnormal_circadian_rhythm0.69113915
97MP0001529_abnormal_vocalization0.66973069
98MP0004145_abnormal_muscle_electrophysio0.66094130
99MP0002254_reproductive_system_inflammat0.64381213
100MP0001119_abnormal_female_reproductive0.64006439

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)5.00823679
2Renal cortical cysts (HP:0000803)3.73747444
3Congenital, generalized hypertrichosis (HP:0004540)3.69137897
4Severe combined immunodeficiency (HP:0004430)3.68753164
5Prostate neoplasm (HP:0100787)3.31948528
6Abnormality of the renal cortex (HP:0011035)3.28967822
7Elevated erythrocyte sedimentation rate (HP:0003565)3.26244139
8Stomach cancer (HP:0012126)3.25727241
9Pancreatic cysts (HP:0001737)3.20975767
10Congenital stationary night blindness (HP:0007642)3.14651265
11Abnormal number of erythroid precursors (HP:0012131)3.02846835
12Acute necrotizing encephalopathy (HP:0006965)3.02708336
13Abnormality of cells of the erythroid lineage (HP:0012130)2.97817390
14Mitochondrial inheritance (HP:0001427)2.97122330
15Lipid accumulation in hepatocytes (HP:0006561)2.96558843
16Molar tooth sign on MRI (HP:0002419)2.93420331
17Abnormality of midbrain morphology (HP:0002418)2.93420331
18Pancreatic fibrosis (HP:0100732)2.79708965
19Combined immunodeficiency (HP:0005387)2.77463945
20Abnormality of the prostate (HP:0008775)2.73393145
21Increased CSF lactate (HP:0002490)2.72808967
22Abnormal mitochondria in muscle tissue (HP:0008316)2.70272356
23Increased hepatocellular lipid droplets (HP:0006565)2.69562330
243-Methylglutaconic aciduria (HP:0003535)2.68367211
25Aplasia/Hypoplasia of the spleen (HP:0010451)2.66776597
26True hermaphroditism (HP:0010459)2.65410129
27Conical tooth (HP:0000698)2.64255640
28Nephronophthisis (HP:0000090)2.58448349
29Aplasia/hypoplasia of the uterus (HP:0008684)2.58279024
30Myositis (HP:0100614)2.58140968
31Acute encephalopathy (HP:0006846)2.51957814
32Asplenia (HP:0001746)2.49842313
33Abnormality of eosinophils (HP:0001879)2.49167491
34Abnormality of T cells (HP:0002843)2.45006717
35Thyroiditis (HP:0100646)2.44132565
36T lymphocytopenia (HP:0005403)2.43474201
37Optic neuritis (HP:0100653)2.41449847
38Retrobulbar optic neuritis (HP:0100654)2.41449847
39Type II lissencephaly (HP:0007260)2.41279738
40Progressive macrocephaly (HP:0004481)2.40956189
41Reticulocytopenia (HP:0001896)2.37918075
42Short tibia (HP:0005736)2.36652816
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.35489335
44Abnormality of the pons (HP:0007361)2.33451003
45Abnormality of the renal medulla (HP:0100957)2.30923258
46Abnormality of T cell number (HP:0011839)2.29709045
47Bilateral microphthalmos (HP:0007633)2.27501307
48Brittle hair (HP:0002299)2.27332055
49Hypoplasia of the uterus (HP:0000013)2.26800663
50Stomatitis (HP:0010280)2.22526977
51Abnormality of T cell physiology (HP:0011840)2.22079918
52Concave nail (HP:0001598)2.18224504
53Sclerocornea (HP:0000647)2.17891183
54Hypoplasia of the pons (HP:0012110)2.17034546
55Aplasia/Hypoplasia of the tibia (HP:0005772)2.16107802
56Keratoconjunctivitis (HP:0001096)2.15871732
57Renal Fanconi syndrome (HP:0001994)2.12327175
58Abnormality of B cell number (HP:0010975)2.08676836
59Hepatocellular necrosis (HP:0001404)2.08019321
60Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07376848
61Pulmonary infiltrates (HP:0002113)2.07356794
62Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06843219
63B lymphocytopenia (HP:0010976)2.06823472
64Medial flaring of the eyebrow (HP:0010747)2.06661429
65Increased serum lactate (HP:0002151)2.03128969
66Hypothermia (HP:0002045)2.00763524
67Macrocytic anemia (HP:0001972)1.99843848
68Optic disc pallor (HP:0000543)1.98723231
69Increased intramyocellular lipid droplets (HP:0012240)1.97095160
70Hepatic necrosis (HP:0002605)1.96622517
71Supernumerary bones of the axial skeleton (HP:0009144)1.95518915
72Abnormality of alanine metabolism (HP:0010916)1.93952438
73Hyperalaninemia (HP:0003348)1.93952438
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93952438
75Type I transferrin isoform profile (HP:0003642)1.93341328
76Abnormal glycosylation (HP:0012345)1.92550969
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92550969
78Abnormal protein N-linked glycosylation (HP:0012347)1.92550969
79Abnormal protein glycosylation (HP:0012346)1.92550969
80IgM deficiency (HP:0002850)1.90151815
81Abnormal drinking behavior (HP:0030082)1.90118568
82Polydipsia (HP:0001959)1.90118568
83Orchitis (HP:0100796)1.89034364
84Increased muscle lipid content (HP:0009058)1.88430651
85Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.86103734
86Exertional dyspnea (HP:0002875)1.84851923
87Lactic acidosis (HP:0003128)1.83636942
88Anhidrosis (HP:0000970)1.82270377
89Parakeratosis (HP:0001036)1.81764956
90Abnormality of male internal genitalia (HP:0000022)1.81651574
91Absent thumb (HP:0009777)1.80155439
92Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.77677985
93Optic nerve hypoplasia (HP:0000609)1.76987513
94Abnormal rod and cone electroretinograms (HP:0008323)1.75934337
95Recurrent bronchitis (HP:0002837)1.75598536
96Pulmonary fibrosis (HP:0002206)1.74587870
97Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.74456137
98Pustule (HP:0200039)1.74076535
99Neutropenia (HP:0001875)1.73175457
100Pancytopenia (HP:0001876)1.71708619

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.94626527
2TAOK33.65044562
3TLK13.51479958
4ZAK3.25191139
5GRK63.02635966
6MAP2K22.93416873
7MAP4K22.91858786
8VRK22.35850855
9ADRBK22.28674340
10IKBKB2.02649344
11WNK42.02277806
12MAP3K141.85643134
13TESK21.80397506
14IKBKE1.69290438
15NUAK11.67849630
16BMPR21.59362532
17STK391.59275639
18FES1.55644162
19MUSK1.53236243
20PHKG21.51892282
21PHKG11.51892282
22MAP4K11.50896975
23KIT1.44391474
24GRK11.44168667
25MAP3K121.41966932
26EPHB21.37790132
27VRK11.33170944
28EPHA31.25545621
29LIMK11.21433525
30STK161.20391816
31TBK11.19592922
32BUB11.11226221
33JAK11.07902624
34WNK31.06453280
35MST41.06222449
36MAPK151.00228696
37WEE10.98071410
38EIF2AK20.96504909
39PINK10.93868497
40MYLK0.93589018
41OXSR10.92016088
42SRPK10.88134722
43PIM10.87413678
44ZAP700.86030064
45MAPK70.85741725
46CAMKK20.84805565
47NEK10.83506479
48MAPK130.83409565
49CHUK0.82569059
50ITK0.81837131
51DYRK20.78472355
52PASK0.74345184
53BCKDK0.72686587
54ERBB30.71830586
55CSF1R0.71217063
56MAPKAPK30.70767407
57TEC0.69940661
58INSRR0.66409682
59SYK0.66018069
60CCNB10.65942058
61ADRBK10.65182287
62MATK0.64803490
63LYN0.62301410
64IGF1R0.61965722
65KDR0.61656533
66LCK0.60104932
67NME10.59898614
68RPS6KA50.59040237
69CDK190.57262878
70DAPK10.56685911
71BRSK10.55114355
72PRKCQ0.54970650
73AURKB0.54555239
74PLK40.53947526
75GRK70.53846090
76BMPR1B0.52396179
77MARK30.49386145
78FRK0.47210858
79GRK50.46061679
80IRAK10.45427651
81ABL20.42916371
82ABL10.40528456
83CDK80.39921483
84CDK30.38912145
85NLK0.38323306
86CHEK20.37544237
87RPS6KA60.36414179
88CSNK1G20.35212588
89RIPK40.34421882
90TESK10.34246245
91ERBB20.33757451
92FLT30.33515407
93CSNK1G30.32528520
94BRSK20.32298799
95DAPK20.31641126
96PRKCI0.31494397
97PRKCD0.31195387
98MAP3K40.30762867
99CSNK2A10.30050653
100BTK0.29480086

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.21300795
2Oxidative phosphorylation_Homo sapiens_hsa001903.51717742
3Parkinsons disease_Homo sapiens_hsa050122.85369737
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70261498
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.64188972
6Proteasome_Homo sapiens_hsa030502.60999108
7Primary immunodeficiency_Homo sapiens_hsa053402.47339715
8Asthma_Homo sapiens_hsa053102.39951429
9RNA polymerase_Homo sapiens_hsa030202.37221593
10Allograft rejection_Homo sapiens_hsa053302.11287829
11Protein export_Homo sapiens_hsa030602.06552107
12Autoimmune thyroid disease_Homo sapiens_hsa053202.04616866
13Graft-versus-host disease_Homo sapiens_hsa053321.92748686
14Alzheimers disease_Homo sapiens_hsa050101.85449325
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.82220382
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.82013995
17Huntingtons disease_Homo sapiens_hsa050161.80338793
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77560212
19Homologous recombination_Homo sapiens_hsa034401.66960491
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57572306
21Cardiac muscle contraction_Homo sapiens_hsa042601.54577814
22Linoleic acid metabolism_Homo sapiens_hsa005911.41441255
23Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34874130
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.32973048
25Type I diabetes mellitus_Homo sapiens_hsa049401.31490864
26Basal transcription factors_Homo sapiens_hsa030221.29485166
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28530171
28Caffeine metabolism_Homo sapiens_hsa002321.28425145
29Fanconi anemia pathway_Homo sapiens_hsa034601.27337911
30RNA degradation_Homo sapiens_hsa030181.24683053
31Phototransduction_Homo sapiens_hsa047441.23381235
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.23344142
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.19726246
34Mismatch repair_Homo sapiens_hsa034301.18791966
35Spliceosome_Homo sapiens_hsa030401.17188910
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.16938311
37Tryptophan metabolism_Homo sapiens_hsa003801.16671279
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14218020
39Chemical carcinogenesis_Homo sapiens_hsa052041.11166967
40Nucleotide excision repair_Homo sapiens_hsa034201.10591635
41Antigen processing and presentation_Homo sapiens_hsa046121.07722075
42Pyrimidine metabolism_Homo sapiens_hsa002401.07615641
43Rheumatoid arthritis_Homo sapiens_hsa053231.05534571
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05361344
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.04669391
46Arachidonic acid metabolism_Homo sapiens_hsa005901.03506451
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02515211
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01350721
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00819290
50Nitrogen metabolism_Homo sapiens_hsa009101.00495567
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97738571
52T cell receptor signaling pathway_Homo sapiens_hsa046600.93870092
53DNA replication_Homo sapiens_hsa030300.91324226
54Steroid hormone biosynthesis_Homo sapiens_hsa001400.91020417
55NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90478757
56Sulfur metabolism_Homo sapiens_hsa009200.89161871
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88164070
58Base excision repair_Homo sapiens_hsa034100.87041316
59One carbon pool by folate_Homo sapiens_hsa006700.86973654
60Purine metabolism_Homo sapiens_hsa002300.85135822
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.77558300
62Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76699139
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.75785252
64Sulfur relay system_Homo sapiens_hsa041220.75246008
65Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75043781
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73828255
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.72368449
68Hematopoietic cell lineage_Homo sapiens_hsa046400.72203043
69Retinol metabolism_Homo sapiens_hsa008300.68376373
70Nicotine addiction_Homo sapiens_hsa050330.64927743
71Selenocompound metabolism_Homo sapiens_hsa004500.64515068
72Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64301116
73Glutathione metabolism_Homo sapiens_hsa004800.63186912
74Olfactory transduction_Homo sapiens_hsa047400.61246857
75Fatty acid elongation_Homo sapiens_hsa000620.56674530
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56214684
77Viral myocarditis_Homo sapiens_hsa054160.53957356
78Peroxisome_Homo sapiens_hsa041460.51862645
79Herpes simplex infection_Homo sapiens_hsa051680.51275050
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.51195147
81p53 signaling pathway_Homo sapiens_hsa041150.51049018
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50372167
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50179801
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48624533
85Metabolic pathways_Homo sapiens_hsa011000.48168694
86Circadian rhythm_Homo sapiens_hsa047100.47444151
87Salivary secretion_Homo sapiens_hsa049700.46867814
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.46558274
89Non-homologous end-joining_Homo sapiens_hsa034500.44768977
90Collecting duct acid secretion_Homo sapiens_hsa049660.44613878
91Fat digestion and absorption_Homo sapiens_hsa049750.43669767
92Morphine addiction_Homo sapiens_hsa050320.42653059
93Regulation of autophagy_Homo sapiens_hsa041400.41096947
94Taste transduction_Homo sapiens_hsa047420.39795849
95RNA transport_Homo sapiens_hsa030130.38728568
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37490920
97TNF signaling pathway_Homo sapiens_hsa046680.35551586
98Measles_Homo sapiens_hsa051620.34738203
99Epstein-Barr virus infection_Homo sapiens_hsa051690.34124535
100Butanoate metabolism_Homo sapiens_hsa006500.33917389

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