

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | muscle filament sliding (GO:0030049) | 9.03016635 |
| 2 | actin-myosin filament sliding (GO:0033275) | 9.03016635 |
| 3 | sarcomere organization (GO:0045214) | 8.61958481 |
| 4 | regulation of skeletal muscle contraction (GO:0014819) | 8.48221514 |
| 5 | sarcoplasmic reticulum calcium ion transport (GO:0070296) | 7.63714952 |
| 6 | positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316) | 7.46151358 |
| 7 | actin-mediated cell contraction (GO:0070252) | 7.40643340 |
| 8 | myofibril assembly (GO:0030239) | 7.38027658 |
| 9 | negative regulation of potassium ion transmembrane transporter activity (GO:1901017) | 7.02938233 |
| 10 | cardiac myofibril assembly (GO:0055003) | 6.99780509 |
| 11 | plasma membrane repair (GO:0001778) | 6.81051859 |
| 12 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880) | 6.70785241 |
| 13 | skeletal muscle contraction (GO:0003009) | 6.49531907 |
| 14 | tricarboxylic acid cycle (GO:0006099) | 6.31369417 |
| 15 | negative regulation of potassium ion transmembrane transport (GO:1901380) | 6.16693916 |
| 16 | skeletal muscle fiber development (GO:0048741) | 6.16036494 |
| 17 | cardiac muscle contraction (GO:0060048) | 6.05286093 |
| 18 | striated muscle contraction (GO:0006941) | 5.99973411 |
| 19 | regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510) | 5.94911943 |
| 20 | regulation of relaxation of muscle (GO:1901077) | 5.92253323 |
| 21 | carnitine shuttle (GO:0006853) | 5.90901243 |
| 22 | regulation of cell communication by electrical coupling (GO:0010649) | 5.79982258 |
| 23 | regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314) | 5.78354216 |
| 24 | skeletal muscle adaptation (GO:0043501) | 5.71515882 |
| 25 | myotube cell development (GO:0014904) | 5.67800300 |
| 26 | creatine metabolic process (GO:0006600) | 5.55122381 |
| 27 | actin filament-based movement (GO:0030048) | 5.51685700 |
| 28 | regulation of actin filament-based movement (GO:1903115) | 5.50905188 |
| 29 | actomyosin structure organization (GO:0031032) | 5.49606722 |
| 30 | response to stimulus involved in regulation of muscle adaptation (GO:0014874) | 5.45400097 |
| 31 | regulation of acyl-CoA biosynthetic process (GO:0050812) | 5.41734472 |
| 32 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO | 5.36500668 |
| 33 | cardiac muscle cell development (GO:0055013) | 5.34369244 |
| 34 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 5.12675948 |
| 35 | fatty acid transmembrane transport (GO:1902001) | 5.09422727 |
| 36 | cardiac cell development (GO:0055006) | 4.99985482 |
| 37 | regulation of cofactor metabolic process (GO:0051193) | 4.91827168 |
| 38 | regulation of coenzyme metabolic process (GO:0051196) | 4.91827168 |
| 39 | heart process (GO:0003015) | 4.79043029 |
| 40 | heart contraction (GO:0060047) | 4.79043029 |
| 41 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 4.70863419 |
| 42 | regulation of striated muscle contraction (GO:0006942) | 4.57840692 |
| 43 | skeletal muscle tissue development (GO:0007519) | 4.57569622 |
| 44 | ventricular cardiac muscle cell action potential (GO:0086005) | 4.50890607 |
| 45 | cardiac muscle tissue morphogenesis (GO:0055008) | 4.50422378 |
| 46 | cardiac muscle hypertrophy (GO:0003300) | 4.46339700 |
| 47 | muscle contraction (GO:0006936) | 4.43024289 |
| 48 | regulation of sarcomere organization (GO:0060297) | 4.40357188 |
| 49 | carnitine transmembrane transport (GO:1902603) | 4.38697632 |
| 50 | striated muscle hypertrophy (GO:0014897) | 4.37576249 |
| 51 | response to inactivity (GO:0014854) | 4.35742111 |
| 52 | adult heart development (GO:0007512) | 4.35391225 |
| 53 | glycogen catabolic process (GO:0005980) | 4.34783455 |
| 54 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.34022754 |
| 55 | pyrimidine ribonucleoside catabolic process (GO:0046133) | 4.29580244 |
| 56 | response to muscle activity (GO:0014850) | 4.22464957 |
| 57 | muscle tissue morphogenesis (GO:0060415) | 4.20816823 |
| 58 | heart trabecula formation (GO:0060347) | 4.20608457 |
| 59 | striated muscle adaptation (GO:0014888) | 4.20232522 |
| 60 | regulation of membrane repolarization (GO:0060306) | 4.18965208 |
| 61 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 4.18833504 |
| 62 | muscle cell cellular homeostasis (GO:0046716) | 4.16196447 |
| 63 | bundle of His cell to Purkinje myocyte communication (GO:0086069) | 4.13947345 |
| 64 | striated muscle atrophy (GO:0014891) | 4.11107244 |
| 65 | respiratory electron transport chain (GO:0022904) | 4.09982053 |
| 66 | cytidine deamination (GO:0009972) | 4.08715576 |
| 67 | cytidine metabolic process (GO:0046087) | 4.08715576 |
| 68 | cytidine catabolic process (GO:0006216) | 4.08715576 |
| 69 | 2-oxoglutarate metabolic process (GO:0006103) | 4.07923269 |
| 70 | NADH metabolic process (GO:0006734) | 4.07009658 |
| 71 | muscle system process (GO:0003012) | 4.06236144 |
| 72 | glucan catabolic process (GO:0009251) | 4.05694351 |
| 73 | oxidative phosphorylation (GO:0006119) | 4.03327347 |
| 74 | regulation of sequestering of triglyceride (GO:0010889) | 4.03058501 |
| 75 | amino-acid betaine transport (GO:0015838) | 4.00112052 |
| 76 | carnitine transport (GO:0015879) | 4.00112052 |
| 77 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 3.99698656 |
| 78 | regulation of sulfur metabolic process (GO:0042762) | 3.99256936 |
| 79 | electron transport chain (GO:0022900) | 3.97361299 |
| 80 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 3.93953027 |
| 81 | muscle hypertrophy (GO:0014896) | 3.87111275 |
| 82 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.86495913 |
| 83 | ATP synthesis coupled proton transport (GO:0015986) | 3.86495913 |
| 84 | ventricular cardiac muscle tissue morphogenesis (GO:0055010) | 3.81689614 |
| 85 | cellular polysaccharide catabolic process (GO:0044247) | 3.77895357 |
| 86 | glycogen metabolic process (GO:0005977) | 3.76414677 |
| 87 | negative regulation of calcium ion transmembrane transport (GO:1903170) | 3.76250774 |
| 88 | negative regulation of calcium ion transmembrane transporter activity (GO:1901020) | 3.76250774 |
| 89 | response to activity (GO:0014823) | 3.75454879 |
| 90 | striated muscle cell development (GO:0055002) | 3.74022617 |
| 91 | muscle organ morphogenesis (GO:0048644) | 3.73800905 |
| 92 | muscle structure development (GO:0061061) | 3.72850003 |
| 93 | muscle organ development (GO:0007517) | 3.71184205 |
| 94 | cellular glucan metabolic process (GO:0006073) | 3.68573895 |
| 95 | glucan metabolic process (GO:0044042) | 3.68573895 |
| 96 | fructose metabolic process (GO:0006000) | 3.68014082 |
| 97 | regulation of calcium ion transmembrane transporter activity (GO:1901019) | 3.67723110 |
| 98 | regulation of calcium ion transmembrane transport (GO:1903169) | 3.67723110 |
| 99 | glycogen biosynthetic process (GO:0005978) | 3.66089207 |
| 100 | glucan biosynthetic process (GO:0009250) | 3.66089207 |
| 101 | muscle cell fate commitment (GO:0042693) | 3.62853156 |
| 102 | gluconeogenesis (GO:0006094) | 3.59825822 |
| 103 | polysaccharide catabolic process (GO:0000272) | 3.57767461 |
| 104 | muscle fiber development (GO:0048747) | 3.56707582 |
| 105 | skeletal muscle tissue regeneration (GO:0043403) | 3.55737847 |
| 106 | positive regulation of cation channel activity (GO:2001259) | 3.54187008 |
| 107 | muscle adaptation (GO:0043500) | 3.50855872 |
| 108 | muscle atrophy (GO:0014889) | 3.49935199 |
| 109 | muscle hypertrophy in response to stress (GO:0003299) | 3.49595411 |
| 110 | cardiac muscle adaptation (GO:0014887) | 3.49595411 |
| 111 | cardiac muscle hypertrophy in response to stress (GO:0014898) | 3.49595411 |
| 112 | neuronal action potential propagation (GO:0019227) | 3.49040344 |
| 113 | negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315) | 3.48801187 |
| 114 | ubiquinone biosynthetic process (GO:0006744) | 3.44518725 |
| 115 | regulation of ATPase activity (GO:0043462) | 3.42214721 |
| 116 | regulation of ATP catabolic process (GO:1903289) | 3.42214721 |
| 117 | succinate metabolic process (GO:0006105) | 3.41585976 |
| 118 | positive regulation of myotube differentiation (GO:0010831) | 3.40961804 |
| 119 | negative regulation of potassium ion transport (GO:0043267) | 3.39210776 |
| 120 | regulation of the force of heart contraction (GO:0002026) | 3.38397618 |
| 121 | cardiac muscle cell action potential involved in contraction (GO:0086002) | 3.36498069 |
| 122 | muscle cell development (GO:0055001) | 3.31197129 |
| 123 | relaxation of muscle (GO:0090075) | 3.29703712 |
| 124 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.26905014 |
| 125 | regulation of muscle system process (GO:0090257) | 3.26550120 |
| 126 | myoblast fusion (GO:0007520) | 3.26138418 |
| 127 | positive regulation of mitochondrial calcium ion concentration (GO:0051561) | 3.24823170 |
| 128 | striated muscle tissue development (GO:0014706) | 3.23671839 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 6.99170873 |
| 2 | BP1_19119308_ChIP-ChIP_Hs578T_Human | 4.65193617 |
| 3 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 4.62330817 |
| 4 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 4.46058846 |
| 5 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 3.87375859 |
| 6 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 3.87375859 |
| 7 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 3.80123488 |
| 8 | ZNF263_19887448_ChIP-Seq_K562_Human | 3.39050267 |
| 9 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 3.34448674 |
| 10 | RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.81182977 |
| 11 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.78611003 |
| 12 | MEF2A_21415370_ChIP-Seq_HL-1_Mouse | 2.72416769 |
| 13 | CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human | 2.59841672 |
| 14 | * RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.47478097 |
| 15 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 2.26258724 |
| 16 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 2.23997151 |
| 17 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 2.18747038 |
| 18 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 2.09963154 |
| 19 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 2.08847260 |
| 20 | IGF1R_20145208_ChIP-Seq_DFB_Human | 2.02669935 |
| 21 | VDR_22108803_ChIP-Seq_LS180_Human | 1.92008840 |
| 22 | GBX2_23144817_ChIP-Seq_PC3_Human | 1.89968618 |
| 23 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 1.82001514 |
| 24 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 1.75493398 |
| 25 | EZH2_22144423_ChIP-Seq_EOC_Human | 1.74646873 |
| 26 | * BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.74241655 |
| 27 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.70188669 |
| 28 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.66339062 |
| 29 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 1.64411008 |
| 30 | CLOCK_20551151_ChIP-Seq_293T_Human | 1.62442441 |
| 31 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 1.56783933 |
| 32 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.56522034 |
| 33 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.55750384 |
| 34 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.53703127 |
| 35 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.53057088 |
| 36 | PPARA_22158963_ChIP-Seq_LIVER_Mouse | 1.52905306 |
| 37 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.49820232 |
| 38 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.48465581 |
| 39 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.43361604 |
| 40 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.42699527 |
| 41 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.41595379 |
| 42 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 1.39133945 |
| 43 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.35934857 |
| 44 | CRX_20693478_ChIP-Seq_RETINA_Mouse | 1.33286050 |
| 45 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.33050090 |
| 46 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.31001357 |
| 47 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.25600124 |
| 48 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.25525136 |
| 49 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.25328720 |
| 50 | SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse | 1.25159949 |
| 51 | CTCF_21964334_ChIP-Seq_BJAB-B_Human | 1.24055229 |
| 52 | LXR_22158963_ChIP-Seq_LIVER_Mouse | 1.23896444 |
| 53 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.22410142 |
| 54 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.22021323 |
| 55 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.21687328 |
| 56 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 1.21261784 |
| 57 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 1.20522926 |
| 58 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.19449675 |
| 59 | CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse | 1.19016122 |
| 60 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.17080894 |
| 61 | GATA1_22025678_ChIP-Seq_K562_Human | 1.16523332 |
| 62 | OCT4_21477851_ChIP-Seq_ESCs_Mouse | 1.16303086 |
| 63 | RXR_22158963_ChIP-Seq_LIVER_Mouse | 1.15436141 |
| 64 | FOXH1_21741376_ChIP-Seq_ESCs_Human | 1.13731078 |
| 65 | OCT4_20526341_ChIP-Seq_ESCs_Human | 1.13225673 |
| 66 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 1.11075422 |
| 67 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.09073129 |
| 68 | GATA6_21074721_ChIP-Seq_CACO-2_Mouse | 1.07363006 |
| 69 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.06880159 |
| 70 | * TP63_22573176_ChIP-Seq_HFKS_Human | 1.06787663 |
| 71 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.06566701 |
| 72 | SMC3_22415368_ChIP-Seq_MEFs_Mouse | 1.06555620 |
| 73 | SOX2_19829295_ChIP-Seq_ESCs_Human | 1.05792325 |
| 74 | NANOG_19829295_ChIP-Seq_ESCs_Human | 1.05792325 |
| 75 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.05704637 |
| 76 | SPI1_20517297_ChIP-Seq_HL60_Human | 1.05575451 |
| 77 | * P68_20966046_ChIP-Seq_HELA_Human | 1.04460087 |
| 78 | RACK7_27058665_Chip-Seq_MCF-7_Human | 1.04304372 |
| 79 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.03986427 |
| 80 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.03986427 |
| 81 | ATF3_27146783_Chip-Seq_COLON_Human | 1.02706981 |
| 82 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.01273500 |
| 83 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.00813103 |
| 84 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.00649367 |
| 85 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.00520195 |
| 86 | CTCF_21964334_Chip-Seq_Bcells_Human | 1.00346511 |
| 87 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.99967660 |
| 88 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 0.98520332 |
| 89 | SMAD2/3_21741376_ChIP-Seq_ESCs_Human | 0.98209228 |
| 90 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.97968442 |
| 91 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.97298367 |
| 92 | BCL6_27268052_Chip-Seq_Bcells_Human | 0.95465097 |
| 93 | SA1_27219007_Chip-Seq_Bcells_Human | 0.95066289 |
| 94 | LYL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.95051491 |
| 95 | AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.94410236 |
| 96 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.93704243 |
| 97 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.93315403 |
| 98 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 0.92851720 |
| 99 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 0.92506743 |
| 100 | * EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.92408230 |
| 101 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.91473929 |
| 102 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.91420991 |
| 103 | GATA1_19941826_ChIP-Seq_K562_Human | 0.91176565 |
| 104 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.90525560 |
| 105 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 0.90132320 |
| 106 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.90129885 |
| 107 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.89463668 |
| 108 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.89315697 |
| 109 | * P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.88052932 |
| 110 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.87981617 |
| 111 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.87682279 |
| 112 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 0.87597005 |
| 113 | CDX2_21074721_ChIP-Seq_CACO-2_Mouse | 0.86945769 |
| 114 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 0.86507396 |
| 115 | GATA6_21074721_ChIP-Seq_CACO-2_Human | 0.86317070 |
| 116 | TDRD3_21172665_ChIP-Seq_MCF-7_Human | 0.86235679 |
| 117 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.85988355 |
| 118 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.85509997 |
| 119 | PHF8_20622853_ChIP-Seq_HELA_Human | 0.85320615 |
| 120 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.84847367 |
| 121 | * YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.84590951 |
| 122 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.84457722 |
| 123 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 0.84406120 |
| 124 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.83859239 |
| 125 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.83859239 |
| 126 | GATA1_19941827_ChIP-Seq_MEL_Mouse | 0.83854775 |
| 127 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.83413984 |
| 128 | E2F1_20622854_ChIP-Seq_HELA_Human | 0.82655055 |
| 129 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.81830902 |
| 130 | * BCOR_27268052_Chip-Seq_Bcells_Human | 0.81721165 |
| 131 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.80595202 |
| 132 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.80220778 |
| 133 | TCF4_23295773_ChIP-Seq_U87_Human | 0.80181542 |
| 134 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.79519168 |
| 135 | GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.79266386 |
| 136 | GATA2_19941826_ChIP-Seq_K562_Human | 0.78407007 |
| 137 | PBX1_22567123_ChIP-ChIP_OVCAR3_Human | 0.78077134 |
| 138 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.78023983 |
| 139 | GATA1_19941827_ChIP-Seq_MEL86_Mouse | 0.77849646 |
| 140 | NANOG_20526341_ChIP-Seq_ESCs_Human | 0.77790566 |
| 141 | NFYB_21822215_ChIP-Seq_K562_Human | 0.77739455 |
| 142 | * STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.77050141 |
| 143 | LUZP1_20508642_ChIP-Seq_ESCs_Mouse | 0.76030291 |
| 144 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.75530339 |
| 145 | CEBPA_26348894_ChIP-Seq_LIVER_Mouse | 0.75258211 |
| 146 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.75206855 |
| 147 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 0.74853685 |
| 148 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.74723411 |
| 149 | CJUN_26792858_Chip-Seq_BT549_Human | 0.74175645 |
| 150 | CBX2_22325352_ChIP-Seq_293T-Rex_Human | 0.73110978 |
| 151 | MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.73007995 |
| 152 | FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human | 0.72902732 |
| 153 | RAC3_21632823_ChIP-Seq_H3396_Human | 0.72872927 |
| 154 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.72089326 |
| 155 | STAT1_20625510_ChIP-Seq_HELA_Human | 0.71833774 |
| 156 | TCF7_22412390_ChIP-Seq_EML_Mouse | 0.71380088 |
| 157 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 0.71034410 |
| 158 | CSB_26484114_Chip-Seq_FIBROBLAST_Human | 0.70932382 |
| 159 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.70821574 |
| 160 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.69922868 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003646_muscle_fatigue | 6.76089825 |
| 2 | MP0002837_dystrophic_cardiac_calcinosis | 5.97223993 |
| 3 | MP0000751_myopathy | 5.64529749 |
| 4 | MP0000749_muscle_degeneration | 4.98919894 |
| 5 | MP0004145_abnormal_muscle_electrophysio | 4.48396963 |
| 6 | MP0004084_abnormal_cardiac_muscle | 4.35929539 |
| 7 | MP0004036_abnormal_muscle_relaxation | 4.35828486 |
| 8 | MP0004215_abnormal_myocardial_fiber | 3.73854536 |
| 9 | MP0005330_cardiomyopathy | 3.35337936 |
| 10 | MP0004087_abnormal_muscle_fiber | 3.35066118 |
| 11 | MP0002106_abnormal_muscle_physiology | 3.30623837 |
| 12 | MP0004130_abnormal_muscle_cell | 3.13390330 |
| 13 | MP0000750_abnormal_muscle_regeneration | 3.08777313 |
| 14 | MP0000747_muscle_weakness | 3.01124733 |
| 15 | MP0005620_abnormal_muscle_contractility | 2.96991911 |
| 16 | MP0002269_muscular_atrophy | 2.91593270 |
| 17 | MP0000759_abnormal_skeletal_muscle | 2.79236468 |
| 18 | MP0005369_muscle_phenotype | 2.70664009 |
| 19 | MP0002972_abnormal_cardiac_muscle | 2.58842043 |
| 20 | MP0004484_altered_response_of | 2.31752008 |
| 21 | MP0003137_abnormal_impulse_conducting | 2.22616210 |
| 22 | MP0010630_abnormal_cardiac_muscle | 2.18712555 |
| 23 | MP0004233_abnormal_muscle_weight | 2.17413423 |
| 24 | MP0008775_abnormal_heart_ventricle | 2.16532202 |
| 25 | MP0001544_abnormal_cardiovascular_syste | 2.15851737 |
| 26 | MP0005385_cardiovascular_system_phenoty | 2.15851737 |
| 27 | MP0006036_abnormal_mitochondrial_physio | 2.08540700 |
| 28 | MP0002332_abnormal_exercise_endurance | 1.89623150 |
| 29 | MP0003221_abnormal_cardiomyocyte_apopto | 1.86112667 |
| 30 | MP0006138_congestive_heart_failure | 1.78445538 |
| 31 | MP0005666_abnormal_adipose_tissue | 1.64589762 |
| 32 | MP0003828_pulmonary_edema | 1.59841321 |
| 33 | MP0004085_abnormal_heartbeat | 1.50029701 |
| 34 | MP0004185_abnormal_adipocyte_glucose | 1.47910067 |
| 35 | MP0004510_myositis | 1.32576349 |
| 36 | MP0002108_abnormal_muscle_morphology | 1.30925102 |
| 37 | MP0003950_abnormal_plasma_membrane | 1.26457157 |
| 38 | MP0002127_abnormal_cardiovascular_syste | 1.26241940 |
| 39 | MP0000733_abnormal_muscle_development | 1.21360144 |
| 40 | MP0006035_abnormal_mitochondrial_morpho | 1.17494523 |
| 41 | MP0005670_abnormal_white_adipose | 1.14034486 |
| 42 | MP0000343_altered_response_to | 1.13981205 |
| 43 | MP0005375_adipose_tissue_phenotype | 1.13025751 |
| 44 | MP0001661_extended_life_span | 1.07954117 |
| 45 | MP0002234_abnormal_pharynx_morphology | 1.06886555 |
| 46 | MP0005266_abnormal_metabolism | 1.03906982 |
| 47 | MP0000266_abnormal_heart_morphology | 0.95411600 |
| 48 | MP0003806_abnormal_nucleotide_metabolis | 0.95297738 |
| 49 | MP0002971_abnormal_brown_adipose | 0.91865862 |
| 50 | MP0003567_abnormal_fetal_cardiomyocyte | 0.91034311 |
| 51 | MP0005165_increased_susceptibility_to | 0.84158071 |
| 52 | MP0000372_irregular_coat_pigmentation | 0.82704892 |
| 53 | MP0004043_abnormal_pH_regulation | 0.80286534 |
| 54 | MP0004147_increased_porphyrin_level | 0.74863094 |
| 55 | MP0009780_abnormal_chondrocyte_physiolo | 0.69903609 |
| 56 | MP0000230_abnormal_systemic_arterial | 0.68529325 |
| 57 | MP0003705_abnormal_hypodermis_morpholog | 0.66920807 |
| 58 | MP0000013_abnormal_adipose_tissue | 0.66579588 |
| 59 | MP0000003_abnormal_adipose_tissue | 0.60476614 |
| 60 | MP0002078_abnormal_glucose_homeostasis | 0.59824402 |
| 61 | MP0003879_abnormal_hair_cell | 0.58592626 |
| 62 | MP0002128_abnormal_blood_circulation | 0.57276725 |
| 63 | MP0003279_aneurysm | 0.56088854 |
| 64 | MP0004142_abnormal_muscle_tone | 0.53477001 |
| 65 | MP0008961_abnormal_basal_metabolism | 0.53331460 |
| 66 | MP0005319_abnormal_enzyme/_coenzyme | 0.50861951 |
| 67 | MP0002638_abnormal_pupillary_reflex | 0.50816951 |
| 68 | MP0010368_abnormal_lymphatic_system | 0.50388272 |
| 69 | MP0002909_abnormal_adrenal_gland | 0.46951803 |
| 70 | MP0004134_abnormal_chest_morphology | 0.46675418 |
| 71 | MP0005167_abnormal_blood-brain_barrier | 0.46415867 |
| 72 | MP0003656_abnormal_erythrocyte_physiolo | 0.46034775 |
| 73 | MP0005334_abnormal_fat_pad | 0.45983809 |
| 74 | MP0005275_abnormal_skin_tensile | 0.42901590 |
| 75 | MP0001879_abnormal_lymphatic_vessel | 0.42664448 |
| 76 | MP0003566_abnormal_cell_adhesion | 0.40420655 |
| 77 | MP0005083_abnormal_biliary_tract | 0.40162736 |
| 78 | MP0005187_abnormal_penis_morphology | 0.39671320 |
| 79 | MP0005451_abnormal_body_composition | 0.39221889 |
| 80 | MP0005535_abnormal_body_temperature | 0.38891072 |
| 81 | MP0003195_calcinosis | 0.36751380 |
| 82 | MP0002822_catalepsy | 0.36262859 |
| 83 | MP0001853_heart_inflammation | 0.35742228 |
| 84 | MP0005584_abnormal_enzyme/coenzyme_acti | 0.35685524 |
| 85 | MP0009840_abnormal_foam_cell | 0.35576006 |
| 86 | MP0001984_abnormal_olfaction | 0.32871006 |
| 87 | MP0005623_abnormal_meninges_morphology | 0.31483902 |
| 88 | MP0006276_abnormal_autonomic_nervous | 0.31095403 |
| 89 | MP0000767_abnormal_smooth_muscle | 0.30258373 |
| 90 | MP0002118_abnormal_lipid_homeostasis | 0.30224704 |
| 91 | MP0002734_abnormal_mechanical_nocicepti | 0.29953907 |
| 92 | MP0009115_abnormal_fat_cell | 0.29519145 |
| 93 | MP0003948_abnormal_gas_homeostasis | 0.28892104 |
| 94 | MP0005452_abnormal_adipose_tissue | 0.27955292 |
| 95 | MP0002876_abnormal_thyroid_physiology | 0.27399245 |
| 96 | MP0002925_abnormal_cardiovascular_devel | 0.27042868 |
| 97 | MP0009250_abnormal_appendicular_skeleto | 0.26104605 |
| 98 | MP0008569_lethality_at_weaning | 0.25020883 |
| 99 | MP0002114_abnormal_axial_skeleton | 0.24602802 |
| 100 | MP0004924_abnormal_behavior | 0.24482608 |
| 101 | MP0005386_behavior/neurological_phenoty | 0.24482608 |
| 102 | MP0005376_homeostasis/metabolism_phenot | 0.24272218 |
| 103 | MP0001299_abnormal_eye_distance/ | 0.23591313 |
| 104 | MP0002066_abnormal_motor_capabilities/c | 0.23453145 |
| 105 | MP0005423_abnormal_somatic_nervous | 0.22821371 |
| 106 | MP0003045_fibrosis | 0.22734364 |
| 107 | MP0005166_decreased_susceptibility_to | 0.22357046 |
| 108 | MP0010030_abnormal_orbit_morphology | 0.22076980 |
| 109 | MP0002067_abnormal_sensory_capabilities | 0.21771340 |
| 110 | MP0009672_abnormal_birth_weight | 0.21348660 |
| 111 | MP0000762_abnormal_tongue_morphology | 0.21290513 |
| 112 | MP0001614_abnormal_blood_vessel | 0.21286528 |
| 113 | MP0000579_abnormal_nail_morphology | 0.19879372 |
| 114 | MP0004270_analgesia | 0.19861461 |
| 115 | MP0001346_abnormal_lacrimal_gland | 0.19619140 |
| 116 | MP0001784_abnormal_fluid_regulation | 0.19571841 |
| 117 | MP0001727_abnormal_embryo_implantation | 0.19372483 |
| 118 | MP0001943_abnormal_respiration | 0.17945769 |
| 119 | MP0002970_abnormal_white_adipose | 0.17506561 |
| 120 | MP0000249_abnormal_blood_vessel | 0.17262469 |
| 121 | MP0008438_abnormal_cutaneous_collagen | 0.16329928 |
| 122 | MP0002896_abnormal_bone_mineralization | 0.16202683 |
| 123 | MP0005332_abnormal_amino_acid | 0.14909696 |
| 124 | MP0003959_abnormal_lean_body | 0.14745153 |
| 125 | MP0003984_embryonic_growth_retardation | 0.13960922 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Exercise-induced myalgia (HP:0003738) | 7.89471946 |
| 2 | Exercise-induced muscle cramps (HP:0003710) | 7.52628337 |
| 3 | Muscle hypertrophy of the lower extremities (HP:0008968) | 7.09747674 |
| 4 | Calf muscle hypertrophy (HP:0008981) | 6.99078998 |
| 5 | Muscle fiber inclusion bodies (HP:0100299) | 6.17993553 |
| 6 | Muscle fiber splitting (HP:0003555) | 5.94326240 |
| 7 | Sudden death (HP:0001699) | 5.92242182 |
| 8 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 5.91988102 |
| 9 | Myoglobinuria (HP:0002913) | 5.74685748 |
| 10 | Hyporeflexia of lower limbs (HP:0002600) | 5.30073530 |
| 11 | Nemaline bodies (HP:0003798) | 5.24654332 |
| 12 | Ventricular tachycardia (HP:0004756) | 5.19340399 |
| 13 | Abnormality of the calf musculature (HP:0001430) | 5.13483158 |
| 14 | Difficulty running (HP:0009046) | 4.92998641 |
| 15 | EMG: myopathic abnormalities (HP:0003458) | 4.66727370 |
| 16 | Type 1 muscle fiber predominance (HP:0003803) | 4.62437935 |
| 17 | Rhabdomyolysis (HP:0003201) | 4.62065163 |
| 18 | Abnormality of the left ventricular outflow tract (HP:0011103) | 4.55687017 |
| 19 | Subaortic stenosis (HP:0001682) | 4.55687017 |
| 20 | Increased connective tissue (HP:0009025) | 4.51570457 |
| 21 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 4.50003810 |
| 22 | Atrial fibrillation (HP:0005110) | 4.11673976 |
| 23 | Myotonia (HP:0002486) | 4.11426291 |
| 24 | Distal arthrogryposis (HP:0005684) | 3.96328066 |
| 25 | Muscle stiffness (HP:0003552) | 3.93963029 |
| 26 | Lipoatrophy (HP:0100578) | 3.91342201 |
| 27 | Asymmetric septal hypertrophy (HP:0001670) | 3.86557772 |
| 28 | Primary atrial arrhythmia (HP:0001692) | 3.84568489 |
| 29 | Myopathic facies (HP:0002058) | 3.83524932 |
| 30 | Supraventricular tachycardia (HP:0004755) | 3.71637332 |
| 31 | Bundle branch block (HP:0011710) | 3.65837110 |
| 32 | Supraventricular arrhythmia (HP:0005115) | 3.62588795 |
| 33 | Right ventricular cardiomyopathy (HP:0011663) | 3.46926552 |
| 34 | Round ear (HP:0100830) | 3.46702800 |
| 35 | Difficulty climbing stairs (HP:0003551) | 3.44043104 |
| 36 | Palpitations (HP:0001962) | 3.42570476 |
| 37 | Dilated cardiomyopathy (HP:0001644) | 3.40878920 |
| 38 | Abnormality of skeletal muscle fiber size (HP:0012084) | 3.24391092 |
| 39 | Ulnar deviation of the wrist (HP:0003049) | 3.16923112 |
| 40 | Increased variability in muscle fiber diameter (HP:0003557) | 3.16669766 |
| 41 | Areflexia of lower limbs (HP:0002522) | 3.16355957 |
| 42 | Syncope (HP:0001279) | 3.10810975 |
| 43 | Heart block (HP:0012722) | 3.00250234 |
| 44 | Neck muscle weakness (HP:0000467) | 2.98383658 |
| 45 | Prolonged QT interval (HP:0001657) | 2.98090419 |
| 46 | Rimmed vacuoles (HP:0003805) | 2.94682724 |
| 47 | Distal lower limb muscle weakness (HP:0009053) | 2.94032478 |
| 48 | Ventricular arrhythmia (HP:0004308) | 2.87011256 |
| 49 | Abnormal atrioventricular conduction (HP:0005150) | 2.82993802 |
| 50 | Abnormal mitochondria in muscle tissue (HP:0008316) | 2.67366728 |
| 51 | Atrioventricular block (HP:0001678) | 2.65083807 |
| 52 | Acute necrotizing encephalopathy (HP:0006965) | 2.64175623 |
| 53 | Calcaneovalgus deformity (HP:0001848) | 2.58877845 |
| 54 | Limb-girdle muscle atrophy (HP:0003797) | 2.51368040 |
| 55 | Bulbar palsy (HP:0001283) | 2.51298857 |
| 56 | Hepatic necrosis (HP:0002605) | 2.50900639 |
| 57 | Absent phalangeal crease (HP:0006109) | 2.48480151 |
| 58 | Weak cry (HP:0001612) | 2.46194194 |
| 59 | Ventricular fibrillation (HP:0001663) | 2.41106043 |
| 60 | Fetal akinesia sequence (HP:0001989) | 2.34580387 |
| 61 | Ketoacidosis (HP:0001993) | 2.33750553 |
| 62 | Deformed tarsal bones (HP:0008119) | 2.32641328 |
| 63 | Frequent falls (HP:0002359) | 2.32253063 |
| 64 | Slender build (HP:0001533) | 2.32011724 |
| 65 | Abnormality of the neuromuscular junction (HP:0003398) | 2.30972811 |
| 66 | Fatigable weakness (HP:0003473) | 2.30972811 |
| 67 | Muscular dystrophy (HP:0003560) | 2.30878332 |
| 68 | Acute encephalopathy (HP:0006846) | 2.30232153 |
| 69 | Left ventricular hypertrophy (HP:0001712) | 2.29719704 |
| 70 | Hypoplastic ischia (HP:0003175) | 2.26499395 |
| 71 | Facial diplegia (HP:0001349) | 2.24595584 |
| 72 | EMG: neuropathic changes (HP:0003445) | 2.22141843 |
| 73 | Exercise intolerance (HP:0003546) | 2.20876515 |
| 74 | Progressive macrocephaly (HP:0004481) | 2.20135034 |
| 75 | Hepatocellular necrosis (HP:0001404) | 2.20132848 |
| 76 | Increased muscle lipid content (HP:0009058) | 2.19467990 |
| 77 | Distal lower limb amyotrophy (HP:0008944) | 2.19117537 |
| 78 | Abnormal EKG (HP:0003115) | 2.18880172 |
| 79 | Gowers sign (HP:0003391) | 2.10853818 |
| 80 | Mitochondrial inheritance (HP:0001427) | 2.09000764 |
| 81 | Testicular atrophy (HP:0000029) | 2.08927813 |
| 82 | Proximal amyotrophy (HP:0007126) | 2.08825286 |
| 83 | Abnormality of the foot musculature (HP:0001436) | 2.08170521 |
| 84 | Abnormality of the calcaneus (HP:0008364) | 2.07878983 |
| 85 | Hip contracture (HP:0003273) | 2.07510458 |
| 86 | Generalized muscle weakness (HP:0003324) | 2.06982852 |
| 87 | Cerebral edema (HP:0002181) | 2.05145202 |
| 88 | Waddling gait (HP:0002515) | 2.02947811 |
| 89 | Limb-girdle muscle weakness (HP:0003325) | 2.02574135 |
| 90 | Spinal rigidity (HP:0003306) | 2.02432453 |
| 91 | Ragged-red muscle fibers (HP:0003200) | 2.01704585 |
| 92 | Abnormality of alanine metabolism (HP:0010916) | 2.01058685 |
| 93 | Hyperalaninemia (HP:0003348) | 2.01058685 |
| 94 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.01058685 |
| 95 | Progressive muscle weakness (HP:0003323) | 2.00481328 |
| 96 | Abnormal finger flexion creases (HP:0006143) | 2.00061450 |
| 97 | Hypoglycemic coma (HP:0001325) | 1.99756558 |
| 98 | Abnormality of the shoulder girdle musculature (HP:0001435) | 1.98251180 |
| 99 | Increased CSF lactate (HP:0002490) | 1.97404218 |
| 100 | Hyperkalemia (HP:0002153) | 1.97129907 |
| 101 | Abnormality of the ischium (HP:0003174) | 1.96675313 |
| 102 | Palmoplantar keratoderma (HP:0000982) | 1.96324032 |
| 103 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.96134108 |
| 104 | Malignant hyperthermia (HP:0002047) | 1.95813403 |
| 105 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.95573671 |
| 106 | Dicarboxylic aciduria (HP:0003215) | 1.95573671 |
| 107 | Conjunctival hamartoma (HP:0100780) | 1.94118597 |
| 108 | Lower limb amyotrophy (HP:0007210) | 1.93606390 |
| 109 | Increased intramyocellular lipid droplets (HP:0012240) | 1.93123763 |
| 110 | Abnormality of fatty-acid metabolism (HP:0004359) | 1.92477716 |
| 111 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.90105696 |
| 112 | Scapular winging (HP:0003691) | 1.87791115 |
| 113 | Abnormality of the musculature of the pelvis (HP:0001469) | 1.86612232 |
| 114 | Abnormality of the hip-girdle musculature (HP:0001445) | 1.86612232 |
| 115 | Foot dorsiflexor weakness (HP:0009027) | 1.86292483 |
| 116 | Lactic acidosis (HP:0003128) | 1.85182615 |
| 117 | Respiratory insufficiency due to muscle weakness (HP:0002747) | 1.79553568 |
| 118 | Paralysis (HP:0003470) | 1.67790831 |
| 119 | Nonprogressive disorder (HP:0003680) | 1.63677173 |
| 120 | Type 2 muscle fiber atrophy (HP:0003554) | 1.62601214 |
| 121 | Long clavicles (HP:0000890) | 1.60222284 |
| 122 | Shoulder girdle muscle weakness (HP:0003547) | 1.58866110 |
| 123 | Pelvic girdle muscle weakness (HP:0003749) | 1.56968375 |
| 124 | Popliteal pterygium (HP:0009756) | 1.52693957 |
| 125 | Muscle fiber atrophy (HP:0100295) | 1.47756710 |
| 126 | Steppage gait (HP:0003376) | 1.44843914 |
| 127 | Metatarsus adductus (HP:0001840) | 1.44167619 |
| 128 | Ulnar deviation of finger (HP:0009465) | 1.42023439 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | TTN | 7.20841412 |
| 2 | OBSCN | 5.94357033 |
| 3 | PHKG2 | 5.13172045 |
| 4 | PHKG1 | 5.13172045 |
| 5 | PDK4 | 3.21072535 |
| 6 | PDK3 | 3.21072535 |
| 7 | DMPK | 2.61130734 |
| 8 | BCKDK | 2.56731208 |
| 9 | PINK1 | 2.49222248 |
| 10 | NEK1 | 2.47374813 |
| 11 | TRIB3 | 2.42055321 |
| 12 | LMTK2 | 2.34645507 |
| 13 | MYLK | 2.19848657 |
| 14 | NME1 | 2.12731647 |
| 15 | PIK3CA | 2.10073719 |
| 16 | PKN2 | 2.04372734 |
| 17 | PDK2 | 2.01963863 |
| 18 | MUSK | 1.98336841 |
| 19 | MAP2K3 | 1.96419574 |
| 20 | PIK3CG | 1.67914987 |
| 21 | MAP3K7 | 1.57217944 |
| 22 | STK24 | 1.36773569 |
| 23 | MAPK12 | 1.36194556 |
| 24 | TIE1 | 1.27609170 |
| 25 | MARK1 | 1.13641990 |
| 26 | GRK7 | 1.09739685 |
| 27 | PRKAA1 | 0.94778176 |
| 28 | MAPKAPK3 | 0.92950620 |
| 29 | PRKAA2 | 0.92113297 |
| 30 | LIMK1 | 0.91583037 |
| 31 | PRKD1 | 0.90588630 |
| 32 | CAMK2D | 0.87298539 |
| 33 | PAK3 | 0.85685121 |
| 34 | CCNB1 | 0.84766289 |
| 35 | MAP3K3 | 0.83949263 |
| 36 | TRPM7 | 0.83742342 |
| 37 | MAP2K4 | 0.83143845 |
| 38 | ILK | 0.81716161 |
| 39 | MAP2K6 | 0.76590147 |
| 40 | NEK9 | 0.75245287 |
| 41 | ZAK | 0.73785250 |
| 42 | PKN1 | 0.66083181 |
| 43 | MOS | 0.65989217 |
| 44 | MAP3K5 | 0.65416909 |
| 45 | RIPK1 | 0.65225549 |
| 46 | FRK | 0.64839577 |
| 47 | ROCK1 | 0.61916085 |
| 48 | DYRK1B | 0.57835261 |
| 49 | EPHB1 | 0.55673099 |
| 50 | STK4 | 0.53567508 |
| 51 | NME2 | 0.52068454 |
| 52 | INSRR | 0.51745406 |
| 53 | FLT3 | 0.50423571 |
| 54 | CAMK2G | 0.50363022 |
| 55 | MAP2K1 | 0.49606828 |
| 56 | CAMK4 | 0.48586617 |
| 57 | AKT2 | 0.45580487 |
| 58 | STK38L | 0.44687445 |
| 59 | CAMK2B | 0.43775505 |
| 60 | WNK4 | 0.42953663 |
| 61 | PRKACB | 0.42917580 |
| 62 | MAPK11 | 0.39810579 |
| 63 | MAP3K13 | 0.39553263 |
| 64 | TGFBR2 | 0.38550143 |
| 65 | MAPK13 | 0.38120577 |
| 66 | PDGFRA | 0.37288500 |
| 67 | CDC42BPA | 0.36500460 |
| 68 | CAMK2A | 0.36072945 |
| 69 | TAOK1 | 0.35420955 |
| 70 | ROCK2 | 0.33400917 |
| 71 | STK38 | 0.33209017 |
| 72 | PRKACA | 0.32869392 |
| 73 | RPS6KC1 | 0.32614368 |
| 74 | RPS6KL1 | 0.32614368 |
| 75 | MAP3K11 | 0.32535445 |
| 76 | PDPK1 | 0.32491806 |
| 77 | WNK1 | 0.31366217 |
| 78 | PTK6 | 0.28452557 |
| 79 | TAOK2 | 0.27709220 |
| 80 | PRKACG | 0.27341195 |
| 81 | DAPK3 | 0.27211455 |
| 82 | RPS6KA6 | 0.26684132 |
| 83 | PDK1 | 0.26580152 |
| 84 | CAMK1 | 0.26325313 |
| 85 | SGK1 | 0.26071435 |
| 86 | SIK1 | 0.25180248 |
| 87 | SGK2 | 0.24944307 |
| 88 | ICK | 0.24123046 |
| 89 | RPS6KA1 | 0.23500418 |
| 90 | KDR | 0.23329315 |
| 91 | KSR2 | 0.23193330 |
| 92 | DAPK2 | 0.22679879 |
| 93 | MAP3K1 | 0.21133855 |
| 94 | RPS6KB1 | 0.20842559 |
| 95 | PTK2B | 0.19551004 |
| 96 | RPS6KA3 | 0.18782286 |
| 97 | MAPK10 | 0.18744371 |
| 98 | TBK1 | 0.18505200 |
| 99 | PRKG1 | 0.18203475 |
| 100 | SGK3 | 0.16473830 |
| 101 | MARK3 | 0.15511275 |
| 102 | EEF2K | 0.15508283 |
| 103 | MAPK7 | 0.14080927 |
| 104 | BMPR1B | 0.13091640 |
| 105 | LATS2 | 0.13087144 |
| 106 | PRKCH | 0.12141270 |
| 107 | RPS6KB2 | 0.11931332 |
| 108 | MAP3K6 | 0.11924333 |
| 109 | MAPK4 | 0.11663931 |
| 110 | JAK1 | 0.11075690 |
| 111 | STK11 | 0.10904409 |
| 112 | PRKCE | 0.10891769 |
| 113 | JAK2 | 0.10607133 |
| 114 | MTOR | 0.10461741 |
| 115 | LRRK2 | 0.09673352 |
| 116 | PAK6 | 0.09259118 |
| 117 | ERBB3 | 0.09231909 |
| 118 | NLK | 0.08886511 |
| 119 | LATS1 | 0.07974571 |
| 120 | RET | 0.07963018 |
| 121 | TYK2 | 0.07519119 |
| 122 | EPHA3 | 0.06701577 |
| 123 | ZAP70 | 0.04783874 |
| 124 | SGK494 | 0.04525780 |
| 125 | SGK223 | 0.04525780 |
| 126 | TNK2 | 0.03851517 |
| 127 | GSK3B | 0.03221505 |
| 128 | PRKCQ | 0.02622353 |
| 129 | MAPK9 | 0.02224650 |
| 130 | MARK2 | 0.02144807 |
| 131 | PRKCA | 0.01529977 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 5.76697636 |
| 2 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 4.24710606 |
| 3 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 4.09622352 |
| 4 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 3.61260025 |
| 5 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 3.44906037 |
| 6 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 3.37535812 |
| 7 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.34044389 |
| 8 | Parkinsons disease_Homo sapiens_hsa05012 | 3.15071499 |
| 9 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.04504685 |
| 10 | Fatty acid degradation_Homo sapiens_hsa00071 | 2.67907720 |
| 11 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 2.67311988 |
| 12 | Carbon metabolism_Homo sapiens_hsa01200 | 2.55651982 |
| 13 | Alzheimers disease_Homo sapiens_hsa05010 | 2.43492038 |
| 14 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.34675724 |
| 15 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 2.28751442 |
| 16 | Fatty acid metabolism_Homo sapiens_hsa01212 | 1.99838159 |
| 17 | Huntingtons disease_Homo sapiens_hsa05016 | 1.87196563 |
| 18 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.79826992 |
| 19 | Viral myocarditis_Homo sapiens_hsa05416 | 1.64276588 |
| 20 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.58614959 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.58371179 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.50284489 |
| 23 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.49098053 |
| 24 | Insulin resistance_Homo sapiens_hsa04931 | 1.35107907 |
| 25 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 1.33742133 |
| 26 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.28616607 |
| 27 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.26484490 |
| 28 | Insulin signaling pathway_Homo sapiens_hsa04910 | 1.26093512 |
| 29 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.25617889 |
| 30 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 1.24649023 |
| 31 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.08077051 |
| 32 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.02473750 |
| 33 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.00550626 |
| 34 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.97583694 |
| 35 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.97383223 |
| 36 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.96836699 |
| 37 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.94160651 |
| 38 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.93218907 |
| 39 | Galactose metabolism_Homo sapiens_hsa00052 | 0.91732704 |
| 40 | Circadian rhythm_Homo sapiens_hsa04710 | 0.87880180 |
| 41 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.84794393 |
| 42 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83479694 |
| 43 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.82518497 |
| 44 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.75860239 |
| 45 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.74137520 |
| 46 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.69070679 |
| 47 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.68760750 |
| 48 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.66939556 |
| 49 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.66426127 |
| 50 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.65163680 |
| 51 | Focal adhesion_Homo sapiens_hsa04510 | 0.62466075 |
| 52 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57469580 |
| 53 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.56009556 |
| 54 | Long-term potentiation_Homo sapiens_hsa04720 | 0.55458192 |
| 55 | Tight junction_Homo sapiens_hsa04530 | 0.55332595 |
| 56 | Salivary secretion_Homo sapiens_hsa04970 | 0.54737101 |
| 57 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.54704091 |
| 58 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.54616686 |
| 59 | Peroxisome_Homo sapiens_hsa04146 | 0.53506609 |
| 60 | Lysine degradation_Homo sapiens_hsa00310 | 0.52658930 |
| 61 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49055631 |
| 62 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.48699556 |
| 63 | Gastric acid secretion_Homo sapiens_hsa04971 | 0.48453287 |
| 64 | Phototransduction_Homo sapiens_hsa04744 | 0.46687623 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44033543 |
| 66 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.41008273 |
| 67 | Renin secretion_Homo sapiens_hsa04924 | 0.40571044 |
| 68 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36775287 |
| 69 | Olfactory transduction_Homo sapiens_hsa04740 | 0.35084073 |
| 70 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.34364080 |
| 71 | Histidine metabolism_Homo sapiens_hsa00340 | 0.34200602 |
| 72 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.33108393 |
| 73 | Purine metabolism_Homo sapiens_hsa00230 | 0.33030714 |
| 74 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.32179439 |
| 75 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.30990512 |
| 76 | Sulfur relay system_Homo sapiens_hsa04122 | 0.30841069 |
| 77 | Long-term depression_Homo sapiens_hsa04730 | 0.29896111 |
| 78 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.28490276 |
| 79 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.27397287 |
| 80 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27212933 |
| 81 | Metabolic pathways_Homo sapiens_hsa01100 | 0.26869120 |
| 82 | Insulin secretion_Homo sapiens_hsa04911 | 0.26274898 |
| 83 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.24824179 |
| 84 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.23843854 |
| 85 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.21745334 |
| 86 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.21539840 |
| 87 | Amoebiasis_Homo sapiens_hsa05146 | 0.20665715 |
| 88 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.20486960 |
| 89 | Platelet activation_Homo sapiens_hsa04611 | 0.20158352 |
| 90 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.19988909 |
| 91 | Adherens junction_Homo sapiens_hsa04520 | 0.19853121 |
| 92 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.18994510 |
| 93 | Leukocyte transendothelial migration_Homo sapiens_hsa04670 | 0.16442925 |
| 94 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.14452969 |
| 95 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.13867555 |
| 96 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.13225203 |
| 97 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.11979208 |
| 98 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.10979429 |
| 99 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.09429822 |
| 100 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.09190869 |
| 101 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.08703447 |
| 102 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.06565425 |
| 103 | Circadian entrainment_Homo sapiens_hsa04713 | 0.06549485 |
| 104 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.06297554 |
| 105 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.05638976 |
| 106 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.05069358 |
| 107 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.04230281 |
| 108 | Cholinergic synapse_Homo sapiens_hsa04725 | 0.04020660 |
| 109 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.03371811 |
| 110 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.01806834 |
| 111 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | -0.0736985 |
| 112 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | -0.0458028 |
| 113 | Bile secretion_Homo sapiens_hsa04976 | -0.0342256 |
| 114 | Linoleic acid metabolism_Homo sapiens_hsa00591 | -0.0308973 |
| 115 | Sulfur metabolism_Homo sapiens_hsa00920 | -0.0234263 |
| 116 | ABC transporters_Homo sapiens_hsa02010 | -0.0198718 |
| 117 | Gap junction_Homo sapiens_hsa04540 | -0.0088971 |

