ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.72526305
2	ribosomal small subunit assembly (GO:0000028)	4.55962398
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.32918785
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.24029468
5	ATP synthesis coupled proton transport (GO:0015986)	4.24029468
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.03805438
7	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.98152465
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.82687245
9	protein complex biogenesis (GO:0070271)	3.81978594
10	cytidine deamination (GO:0009972)	3.80397818
11	cytidine metabolic process (GO:0046087)	3.80397818
12	cytidine catabolic process (GO:0006216)	3.80397818
13	ribosomal small subunit biogenesis (GO:0042274)	3.75239649
14	viral transcription (GO:0019083)	3.74644677
15	positive regulation of prostaglandin secretion (GO:0032308)	3.70139243
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.63577842
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.63577842
18	behavioral response to nicotine (GO:0035095)	3.63364491
19	translational termination (GO:0006415)	3.62111519
20	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.60118963
21	NADH dehydrogenase complex assembly (GO:0010257)	3.60118963
22	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.60118963
23	maturation of SSU-rRNA (GO:0030490)	3.56871868
24	chaperone-mediated protein transport (GO:0072321)	3.49786418
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.46559576
26	fucose catabolic process (GO:0019317)	3.38560148
27	L-fucose metabolic process (GO:0042354)	3.38560148
28	L-fucose catabolic process (GO:0042355)	3.38560148
29	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.36537446
30	translational elongation (GO:0006414)	3.36247762
31	respiratory chain complex IV assembly (GO:0008535)	3.34068373
32	ribosomal large subunit biogenesis (GO:0042273)	3.30371774
33	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.28714698
34	electron transport chain (GO:0022900)	3.23892802
35	cotranslational protein targeting to membrane (GO:0006613)	3.23867100
36	protein targeting to ER (GO:0045047)	3.23731304
37	respiratory electron transport chain (GO:0022904)	3.21375521
38	protein neddylation (GO:0045116)	3.20513955
39	response to pheromone (GO:0019236)	3.17663089
40	tryptophan catabolic process (GO:0006569)	3.13920263
41	indole-containing compound catabolic process (GO:0042436)	3.13920263
42	indolalkylamine catabolic process (GO:0046218)	3.13920263
43	cytochrome complex assembly (GO:0017004)	3.11664671
44	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.09192974
45	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.09079647
46	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.08438876
47	protein localization to endoplasmic reticulum (GO:0070972)	3.05829100
48	platelet dense granule organization (GO:0060155)	3.05491816
49	positive regulation of fatty acid transport (GO:2000193)	3.05172468
50	preassembly of GPI anchor in ER membrane (GO:0016254)	3.04635346
51	termination of RNA polymerase III transcription (GO:0006386)	3.03507412
52	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03507412
53	rRNA modification (GO:0000154)	3.03394271
54	ncRNA 3-end processing (GO:0043628)	2.97307080
55	tRNA processing (GO:0008033)	2.96893068
56	GTP biosynthetic process (GO:0006183)	2.96172646
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.94516452
58	pseudouridine synthesis (GO:0001522)	2.94375908
59	cellular component biogenesis (GO:0044085)	2.87719912
60	positive regulation of respiratory burst (GO:0060267)	2.87480728
61	kynurenine metabolic process (GO:0070189)	2.86680924
62	positive regulation of icosanoid secretion (GO:0032305)	2.86490780
63	peptidyl-histidine modification (GO:0018202)	2.86045326
64	proteasome assembly (GO:0043248)	2.79793134
65	indolalkylamine metabolic process (GO:0006586)	2.77370958
66	regulation of prostaglandin secretion (GO:0032306)	2.76319261
67	translation (GO:0006412)	2.75383718
68	mannosylation (GO:0097502)	2.75019431
69	piRNA metabolic process (GO:0034587)	2.71496866
70	protein-cofactor linkage (GO:0018065)	2.68597440
71	positive regulation of defense response to virus by host (GO:0002230)	2.66830460
72	negative regulation of telomere maintenance (GO:0032205)	2.66537495
73	viral life cycle (GO:0019058)	2.65713937
74	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.64520014
75	translational initiation (GO:0006413)	2.63412170
76	ribonucleoprotein complex biogenesis (GO:0022613)	2.62386060
77	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.61921413
78	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60614989
79	maturation of 5.8S rRNA (GO:0000460)	2.58791411
80	cellular protein complex disassembly (GO:0043624)	2.58400241
81	parturition (GO:0007567)	2.57757898
82	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.56110730
83	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.56023459
84	rRNA metabolic process (GO:0016072)	2.54624245
85	rRNA processing (GO:0006364)	2.53976289
86	hydrogen ion transmembrane transport (GO:1902600)	2.52548232
87	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.50117625
88	S-adenosylmethionine metabolic process (GO:0046500)	2.49633408
89	tryptophan metabolic process (GO:0006568)	2.49520889
90	ATP biosynthetic process (GO:0006754)	2.49386255
91	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.47525174
92	rRNA catabolic process (GO:0016075)	2.47415954
93	regulation of regulatory T cell differentiation (GO:0045589)	2.47292873
94	proton transport (GO:0015992)	2.47146691
95	UTP metabolic process (GO:0046051)	2.44200405
96	GPI anchor metabolic process (GO:0006505)	2.43120141
97	tRNA metabolic process (GO:0006399)	2.42296690
98	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.42073613
99	branched-chain amino acid catabolic process (GO:0009083)	2.41959184
100	hydrogen transport (GO:0006818)	2.41711821

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.74642355
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.70045570
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.39291333
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.20717274
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.95426447
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.94703313
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.91335904
8	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.83161053
9	VDR_22108803_ChIP-Seq_LS180_Human	2.66955505
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.64729475
11	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.56059164
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51866561
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.46375208
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.11981276
15	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.98977841
16	FOXP3_21729870_ChIP-Seq_TREG_Human	1.96889052
17	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93992037
18	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92616749
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.90471443
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.84353583
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83172753
22	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.80112093
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.77418116
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.76903931
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.71619608
26	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.69119854
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.67098590
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.65536416
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63334113
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.60466554
31	EWS_26573619_Chip-Seq_HEK293_Human	1.56463940
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52564200
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52564200
34	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.50739241
35	AR_20517297_ChIP-Seq_VCAP_Human	1.50681858
36	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.48710014
37	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.48053455
38	FUS_26573619_Chip-Seq_HEK293_Human	1.42910327
39	NCOR_22424771_ChIP-Seq_293T_Human	1.41735388
40	EZH2_22144423_ChIP-Seq_EOC_Human	1.41182621
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.36950412
42	GATA3_26560356_Chip-Seq_TH2_Human	1.36069804
43	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.31119832
44	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30991954
45	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.30791135
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30760156
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26140839
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24722822
49	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.24422967
50	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.23657557
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.22870282
52	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.22581868
53	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.21979407
54	NANOG_20526341_ChIP-Seq_ESCs_Human	1.21934932
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.21518071
56	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.20985989
57	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.20602858
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19674801
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.19431568
60	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.19035590
61	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.18905561
62	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17613699
63	CBP_20019798_ChIP-Seq_JUKART_Human	1.17276777
64	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.17276777
65	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14177903
66	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13735118
67	ER_23166858_ChIP-Seq_MCF-7_Human	1.13239287
68	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.12318575
69	ERA_21632823_ChIP-Seq_H3396_Human	1.12185852
70	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12079596
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12079596
72	P300_19829295_ChIP-Seq_ESCs_Human	1.11662978
73	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.10759445
74	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.07631915
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07598301
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.07037975
77	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06448066
78	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.06417518
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.05689662
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05446669
81	TTF2_22483619_ChIP-Seq_HELA_Human	1.05445018
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03451916
83	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.01847176
84	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.01222548
85	STAT1_20625510_ChIP-Seq_HELA_Human	1.00379470
86	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99746117
87	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99718481
88	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.99347301
89	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97647447
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.97313146
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.96393799
92	ERG_20517297_ChIP-Seq_VCAP_Human	0.96120652
93	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94430967
94	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.93610153
95	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.93587094
96	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.92996162
97	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.90497729
98	BCAT_22108803_ChIP-Seq_LS180_Human	0.89433444
99	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.88830762
100	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.88689194

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.02069404
2	MP0005671_abnormal_response_to	2.97722544
3	MP0002138_abnormal_hepatobiliary_system	2.65866789
4	MP0001835_abnormal_antigen_presentation	2.49445739
5	MP0002102_abnormal_ear_morphology	2.35109131
6	MP0008877_abnormal_DNA_methylation	2.33209130
7	MP0003195_calcinosis	2.31833553
8	MP0008875_abnormal_xenobiotic_pharmacok	2.28831990
9	MP0009379_abnormal_foot_pigmentation	2.25396050
10	MP0002837_dystrophic_cardiac_calcinosis	2.20569902
11	MP0002876_abnormal_thyroid_physiology	2.19502234
12	MP0005646_abnormal_pituitary_gland	2.18345507
13	MP0004147_increased_porphyrin_level	2.09052262
14	MP0005360_urolithiasis	1.99159956
15	MP0006072_abnormal_retinal_apoptosis	1.94957058
16	MP0008872_abnormal_physiological_respon	1.89857217
17	MP0001986_abnormal_taste_sensitivity	1.84034734
18	MP0005551_abnormal_eye_electrophysiolog	1.80873586
19	MP0001968_abnormal_touch/_nociception	1.79527363
20	MP0005645_abnormal_hypothalamus_physiol	1.75328066
21	MP0009785_altered_susceptibility_to	1.74210906
22	MP0002148_abnormal_hypersensitivity_rea	1.71453020
23	MP0001800_abnormal_humoral_immune	1.68713921
24	MP0004885_abnormal_endolymph	1.67697329
25	MP0005084_abnormal_gallbladder_morpholo	1.65063938
26	MP0005075_abnormal_melanosome_morpholog	1.62412530
27	MP0004142_abnormal_muscle_tone	1.56337421
28	MP0000685_abnormal_immune_system	1.55713173
29	MP0002736_abnormal_nociception_after	1.55407002
30	MP0001501_abnormal_sleep_pattern	1.46385909
31	MP0002234_abnormal_pharynx_morphology	1.45869411
32	MP0000372_irregular_coat_pigmentation	1.44017040
33	MP0003866_abnormal_defecation	1.42979550
34	MP0001873_stomach_inflammation	1.39829843
35	MP0003011_delayed_dark_adaptation	1.36280905
36	MP0003646_muscle_fatigue	1.35752419
37	MP0001790_abnormal_immune_system	1.32632576
38	MP0005387_immune_system_phenotype	1.32632576
39	MP0005000_abnormal_immune_tolerance	1.31639238
40	MP0001764_abnormal_homeostasis	1.31303163
41	MP0010155_abnormal_intestine_physiology	1.29996405
42	MP0006276_abnormal_autonomic_nervous	1.29863424
43	MP0003806_abnormal_nucleotide_metabolis	1.28792749
44	MP0001919_abnormal_reproductive_system	1.28017496
45	MP0003786_premature_aging	1.26932354
46	MP0004043_abnormal_pH_regulation	1.25765507
47	MP0003718_maternal_effect	1.23930854
48	MP0005389_reproductive_system_phenotype	1.23365107
49	MP0002723_abnormal_immune_serum	1.22933760
50	MP0005253_abnormal_eye_physiology	1.21936103
51	MP0003787_abnormal_imprinting	1.19692514
52	MP0002163_abnormal_gland_morphology	1.18653016
53	MP0009333_abnormal_splenocyte_physiolog	1.17859623
54	MP0005332_abnormal_amino_acid	1.15162160
55	MP0003878_abnormal_ear_physiology	1.13805241
56	MP0005377_hearing/vestibular/ear_phenot	1.13805241
57	MP0008775_abnormal_heart_ventricle	1.13623432
58	MP0002420_abnormal_adaptive_immunity	1.10936791
59	MP0001819_abnormal_immune_cell	1.10050183
60	MP0001905_abnormal_dopamine_level	1.09463022
61	MP0008995_early_reproductive_senescence	1.07941241
62	MP0002452_abnormal_antigen_presenting	1.07312788
63	MP0009764_decreased_sensitivity_to	1.05639299
64	MP0003724_increased_susceptibility_to	1.04320863
65	MP0002272_abnormal_nervous_system	1.03173873
66	MP0001293_anophthalmia	1.01451644
67	MP0005410_abnormal_fertilization	1.00275250
68	MP0005085_abnormal_gallbladder_physiolo	0.99780637
69	MP0005636_abnormal_mineral_homeostasis	0.99282796
70	MP0003186_abnormal_redox_activity	0.98414874
71	MP0006036_abnormal_mitochondrial_physio	0.98057162
72	MP0002638_abnormal_pupillary_reflex	0.96197158
73	MP0004145_abnormal_muscle_electrophysio	0.95488651
74	MP0002139_abnormal_hepatobiliary_system	0.94978675
75	MP0001845_abnormal_inflammatory_respons	0.94480256
76	MP0000631_abnormal_neuroendocrine_gland	0.93516942
77	MP0000230_abnormal_systemic_arterial	0.91972530
78	MP0009745_abnormal_behavioral_response	0.89316859
79	MP0006082_CNS_inflammation	0.89089131
80	MP0002693_abnormal_pancreas_physiology	0.88098505
81	MP0000689_abnormal_spleen_morphology	0.88003318
82	MP0005379_endocrine/exocrine_gland_phen	0.87239316
83	MP0002095_abnormal_skin_pigmentation	0.87095195
84	MP0001765_abnormal_ion_homeostasis	0.87093880
85	MP0003763_abnormal_thymus_physiology	0.86466594
86	MP0005025_abnormal_response_to	0.86343120
87	MP0002933_joint_inflammation	0.84330355
88	MP0001727_abnormal_embryo_implantation	0.82896106
89	MP0000716_abnormal_immune_system	0.82610577
90	MP0008058_abnormal_DNA_repair	0.81823597
91	MP0002733_abnormal_thermal_nociception	0.81791254
92	MP0009643_abnormal_urine_homeostasis	0.80209569
93	MP0003436_decreased_susceptibility_to	0.78985631
94	MP0004019_abnormal_vitamin_homeostasis	0.76458330
95	MP0001486_abnormal_startle_reflex	0.76238490
96	MP0001970_abnormal_pain_threshold	0.75182914
97	MP0001485_abnormal_pinna_reflex	0.74758259
98	MP0001663_abnormal_digestive_system	0.74752479
99	MP0002938_white_spotting	0.74560708
100	MP0002398_abnormal_bone_marrow	0.73634468

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.57045925
2	Acute necrotizing encephalopathy (HP:0006965)	3.48188652
3	Pancreatic fibrosis (HP:0100732)	3.44201609
4	Mitochondrial inheritance (HP:0001427)	3.43563437
5	Congenital stationary night blindness (HP:0007642)	3.36515617
6	IgG deficiency (HP:0004315)	3.27976633
7	Increased CSF lactate (HP:0002490)	3.27467798
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.23509565
9	True hermaphroditism (HP:0010459)	3.17172173
10	Abnormality of midbrain morphology (HP:0002418)	3.14312401
11	Molar tooth sign on MRI (HP:0002419)	3.14312401
12	Hepatocellular necrosis (HP:0001404)	3.12926255
13	Type II lissencephaly (HP:0007260)	3.01922657
14	Acute encephalopathy (HP:0006846)	2.99509739
15	Progressive macrocephaly (HP:0004481)	2.95996557
16	Hepatic necrosis (HP:0002605)	2.94798453
17	Nephronophthisis (HP:0000090)	2.90493726
18	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.90181814
19	Attenuation of retinal blood vessels (HP:0007843)	2.90168700
20	3-Methylglutaconic aciduria (HP:0003535)	2.86682200
21	Abnormality of B cell number (HP:0010975)	2.83191409
22	Abnormality of the renal cortex (HP:0011035)	2.81777981
23	Stomatitis (HP:0010280)	2.80659308
24	Methylmalonic acidemia (HP:0002912)	2.73608272
25	Methylmalonic aciduria (HP:0012120)	2.71648590
26	Constricted visual fields (HP:0001133)	2.71342596
27	Elevated erythrocyte sedimentation rate (HP:0003565)	2.70557117
28	Lipid accumulation in hepatocytes (HP:0006561)	2.69453851
29	Congenital, generalized hypertrichosis (HP:0004540)	2.68254209
30	Increased hepatocellular lipid droplets (HP:0006565)	2.66070949
31	Reticulocytopenia (HP:0001896)	2.65316345
32	Cerebral edema (HP:0002181)	2.64403208
33	Abolished electroretinogram (ERG) (HP:0000550)	2.62166862
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.60177950
35	Panhypogammaglobulinemia (HP:0003139)	2.55816704
36	Optic disc pallor (HP:0000543)	2.55279390
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.54650056
38	Thyroiditis (HP:0100646)	2.52150923
39	Severe combined immunodeficiency (HP:0004430)	2.51875264
40	Increased serum lactate (HP:0002151)	2.51060917
41	B lymphocytopenia (HP:0010976)	2.49737194
42	Abnormal drinking behavior (HP:0030082)	2.47675886
43	Polydipsia (HP:0001959)	2.47675886
44	Abnormality of the renal medulla (HP:0100957)	2.44946509
45	Lactic acidosis (HP:0003128)	2.34003804
46	Lethargy (HP:0001254)	2.27752448
47	Abnormality of cells of the erythroid lineage (HP:0012130)	2.27129139
48	Decreased central vision (HP:0007663)	2.26995769
49	Aplasia/hypoplasia of the uterus (HP:0008684)	2.26830473
50	Abnormal number of erythroid precursors (HP:0012131)	2.26113030
51	Increased intramyocellular lipid droplets (HP:0012240)	2.25692632
52	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.24848665
53	Renal cortical cysts (HP:0000803)	2.24182852
54	Hypoproteinemia (HP:0003075)	2.20209979
55	Medial flaring of the eyebrow (HP:0010747)	2.17143650
56	Chronic hepatic failure (HP:0100626)	2.15897657
57	Abnormality of macular pigmentation (HP:0008002)	2.13798947
58	Renal Fanconi syndrome (HP:0001994)	2.12391789
59	Abnormality of vitamin B metabolism (HP:0004340)	2.11908524
60	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.11899254
61	Ketosis (HP:0001946)	2.11533784
62	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.10343050
63	Type 2 muscle fiber atrophy (HP:0003554)	2.10305329
64	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.09978156
65	Cystic liver disease (HP:0006706)	2.09146162
66	Sclerocornea (HP:0000647)	2.08126679
67	Polyuria (HP:0000103)	2.07444501
68	Absent thumb (HP:0009777)	2.06534746
69	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.05107608
70	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.05107608
71	Abnormality of the prostate (HP:0008775)	2.00874697
72	Abnormal biliary tract physiology (HP:0012439)	1.98249850
73	Bile duct proliferation (HP:0001408)	1.98249850
74	Hypoplasia of the uterus (HP:0000013)	1.96366430
75	Abnormality of T cell physiology (HP:0011840)	1.95761301
76	Increased corneal curvature (HP:0100692)	1.95302622
77	Keratoconus (HP:0000563)	1.95302622
78	Pancytopenia (HP:0001876)	1.94741567
79	Increased muscle lipid content (HP:0009058)	1.94682832
80	Abnormality of urine glucose concentration (HP:0011016)	1.93230994
81	Glycosuria (HP:0003076)	1.93230994
82	Macrocytic anemia (HP:0001972)	1.92905239
83	Pendular nystagmus (HP:0012043)	1.92206052
84	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.92015009
85	Dicarboxylic aciduria (HP:0003215)	1.92015009
86	Tubular atrophy (HP:0000092)	1.91144247
87	Hyperglycinemia (HP:0002154)	1.89998340
88	Abnormality of T cells (HP:0002843)	1.86477430
89	Severe muscular hypotonia (HP:0006829)	1.82536275
90	Abnormality of DNA repair (HP:0003254)	1.81357350
91	Congenital hepatic fibrosis (HP:0002612)	1.80957764
92	Respiratory failure (HP:0002878)	1.80884631
93	Colon cancer (HP:0003003)	1.80798168
94	Decreased circulating renin level (HP:0003351)	1.80646830
95	Hypomagnesemia (HP:0002917)	1.79927786
96	Combined immunodeficiency (HP:0005387)	1.79582810
97	Stomach cancer (HP:0012126)	1.76080615
98	IgM deficiency (HP:0002850)	1.75431909
99	Abnormality of serine family amino acid metabolism (HP:0010894)	1.75166828
100	Abnormality of glycine metabolism (HP:0010895)	1.75166828

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	3.71492810
2	TAOK3	3.11802618
3	MAP4K2	2.90550009
4	BCKDK	2.78792135
5	FRK	2.77832726
6	ADRBK2	2.76528059
7	NUAK1	2.65745615
8	ZAK	2.64846406
9	TLK1	2.55723215
10	GRK1	2.25424551
11	STK16	2.14776090
12	KIT	2.13295017
13	TEC	2.12199853
14	WNK4	2.04751496
15	MAP4K1	2.02126114
16	FES	1.93124549
17	VRK2	1.88455066
18	TIE1	1.79516290
19	EIF2AK3	1.68000413
20	BMPR1B	1.62272103
21	IKBKB	1.54478603
22	MST4	1.52116149
23	ITK	1.51301875
24	CDK19	1.38632116
25	VRK1	1.37764290
26	OXSR1	1.34381836
27	PINK1	1.33065795
28	DYRK2	1.23638323
29	MUSK	1.21715479
30	SYK	1.19887232
31	PIK3CA	1.17804590
32	STK39	1.14291095
33	WNK3	1.10178078
34	MAP2K6	1.09733151
35	MAPKAPK3	1.07704900
36	GRK6	1.05639435
37	DAPK2	1.00731488
38	ACVR1B	0.96275732
39	BTK	0.92076285
40	CSF1R	0.91992935
41	PHKG1	0.91861794
42	PHKG2	0.91861794
43	EIF2AK1	0.91801372
44	PASK	0.91150246
45	MAP2K2	0.86609320
46	MAP3K12	0.86330551
47	NME1	0.85383232
48	DAPK1	0.83883468
49	ADRBK1	0.82153083
50	IKBKE	0.80303026
51	TRIM28	0.79971177
52	KDR	0.77710930
53	PRKCQ	0.76096534
54	TNK2	0.73958898
55	MAP2K7	0.73954676
56	LYN	0.73453920
57	CSNK1G3	0.72137980
58	PIK3CG	0.71369605
59	LCK	0.69073219
60	CSNK1G1	0.68295755
61	INSRR	0.67908818
62	MAP3K4	0.65111617
63	RPS6KA4	0.65057032
64	MAPK13	0.63516868
65	CAMKK2	0.63508136
66	EIF2AK2	0.61082291
67	PLK3	0.60512742
68	RPS6KA5	0.58574263
69	TGFBR1	0.55858960
70	FLT3	0.55147116
71	RPS6KB2	0.53837642
72	IRAK1	0.52915662
73	NEK1	0.52726899
74	PDK2	0.52675726
75	MKNK1	0.51702300
76	CSNK1A1L	0.51053108
77	GRK5	0.50551776
78	CSNK1G2	0.50118312
79	PRKCG	0.49006479
80	IGF1R	0.47028383
81	PRKCE	0.46789451
82	PRKCA	0.46707955
83	TAF1	0.46548186
84	TESK2	0.46198999
85	NME2	0.45742353
86	MAPKAPK5	0.45632294
87	BMPR2	0.45527061
88	PRKACA	0.43618796
89	CSNK1A1	0.40976332
90	PLK4	0.40011335
91	CAMK1	0.39775766
92	PAK3	0.38668361
93	MYLK	0.38466694
94	ABL1	0.38196687
95	PLK2	0.37523131
96	PIM1	0.36429204
97	LIMK1	0.36331866
98	CSNK2A2	0.35908520
99	TBK1	0.35470579
100	OBSCN	0.34965766

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.44691066
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.23199545
3	Asthma_Homo sapiens_hsa05310	2.90779506
4	Proteasome_Homo sapiens_hsa03050	2.78824417
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.74225323
6	Parkinsons disease_Homo sapiens_hsa05012	2.51211255
7	Allograft rejection_Homo sapiens_hsa05330	2.45057234
8	RNA polymerase_Homo sapiens_hsa03020	2.42016511
9	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.30887796
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.22014298
11	Primary immunodeficiency_Homo sapiens_hsa05340	2.17696116
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.16167470
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.14044794
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96173890
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.91762952
16	Phototransduction_Homo sapiens_hsa04744	1.91530641
17	Protein export_Homo sapiens_hsa03060	1.78338290
18	Caffeine metabolism_Homo sapiens_hsa00232	1.63212224
19	Alzheimers disease_Homo sapiens_hsa05010	1.57071827
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.55439810
21	Huntingtons disease_Homo sapiens_hsa05016	1.54970532
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.52834639
23	Sulfur metabolism_Homo sapiens_hsa00920	1.51560717
24	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.50078738
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.47937657
26	One carbon pool by folate_Homo sapiens_hsa00670	1.43836824
27	RNA degradation_Homo sapiens_hsa03018	1.41719046
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.40780518
29	Propanoate metabolism_Homo sapiens_hsa00640	1.39950590
30	Butanoate metabolism_Homo sapiens_hsa00650	1.38708521
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.38006991
32	Homologous recombination_Homo sapiens_hsa03440	1.37123795
33	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.31741745
34	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.30560064
35	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.28802311
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.26490913
37	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24535468
38	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.22092914
39	Fat digestion and absorption_Homo sapiens_hsa04975	1.20867501
40	Nitrogen metabolism_Homo sapiens_hsa00910	1.17712739
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.17027177
42	Antigen processing and presentation_Homo sapiens_hsa04612	1.13846227
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.13783702
44	Basal transcription factors_Homo sapiens_hsa03022	1.13044051
45	Rheumatoid arthritis_Homo sapiens_hsa05323	1.11652467
46	Purine metabolism_Homo sapiens_hsa00230	1.10274306
47	Peroxisome_Homo sapiens_hsa04146	1.07495933
48	Fanconi anemia pathway_Homo sapiens_hsa03460	1.02242744
49	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97700117
50	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94542681
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89061987
52	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.83360661
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81988922
54	Nucleotide excision repair_Homo sapiens_hsa03420	0.81847848
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.80898666
56	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.78139899
57	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77268698
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76003379
59	Mismatch repair_Homo sapiens_hsa03430	0.74620315
60	Retinol metabolism_Homo sapiens_hsa00830	0.74155064
61	Selenocompound metabolism_Homo sapiens_hsa00450	0.73605064
62	Metabolic pathways_Homo sapiens_hsa01100	0.72537785
63	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72192351
64	Regulation of autophagy_Homo sapiens_hsa04140	0.71387886
65	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.71264246
66	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.67832326
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.66708843
68	Olfactory transduction_Homo sapiens_hsa04740	0.66420316
69	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66291721
70	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65452376
71	Sulfur relay system_Homo sapiens_hsa04122	0.61512057
72	RNA transport_Homo sapiens_hsa03013	0.60681305
73	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.55345854
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.54203480
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53446976
76	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.53355679
77	Base excision repair_Homo sapiens_hsa03410	0.53143851
78	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.52078769
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.51226161
80	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.50347757
81	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49540750
82	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.49030161
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47361206
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.47275252
85	Fatty acid elongation_Homo sapiens_hsa00062	0.46139332
86	Viral myocarditis_Homo sapiens_hsa05416	0.45939751
87	Spliceosome_Homo sapiens_hsa03040	0.45497755
88	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.44443438
89	Fatty acid degradation_Homo sapiens_hsa00071	0.41387399
90	Glutathione metabolism_Homo sapiens_hsa00480	0.40760588
91	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.39526860
92	Mineral absorption_Homo sapiens_hsa04978	0.39495554
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38708905
94	Taste transduction_Homo sapiens_hsa04742	0.38693115
95	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.37819318
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37730804
97	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.35158735
98	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.35151772
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.34880420
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33483989

RPL3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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