ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	4.56198964
2	water-soluble vitamin biosynthetic process (GO:0042364)	4.47467190
3	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.42849295
4	DNA deamination (GO:0045006)	4.41154561
5	kidney morphogenesis (GO:0060993)	4.10634950
6	behavioral response to nicotine (GO:0035095)	4.05836919
7	protein neddylation (GO:0045116)	3.90542966
8	fucose catabolic process (GO:0019317)	3.89603585
9	L-fucose metabolic process (GO:0042354)	3.89603585
10	L-fucose catabolic process (GO:0042355)	3.89603585
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.83028586
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.83028586
13	NADH dehydrogenase complex assembly (GO:0010257)	3.83028586
14	cellular ketone body metabolic process (GO:0046950)	3.81485819
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.79427389
16	protein complex biogenesis (GO:0070271)	3.76474991
17	preassembly of GPI anchor in ER membrane (GO:0016254)	3.66637478
18	ketone body metabolic process (GO:1902224)	3.55499012
19	mitochondrial respiratory chain complex assembly (GO:0033108)	3.51493918
20	negative regulation of telomere maintenance (GO:0032205)	3.49536551
21	respiratory chain complex IV assembly (GO:0008535)	3.46779269
22	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.36558243
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.32105821
24	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.32105821
25	lactate metabolic process (GO:0006089)	3.31793673
26	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.31782139
27	iron coordination entity transport (GO:1901678)	3.29881055
28	GTP biosynthetic process (GO:0006183)	3.29861516
29	metanephric tubule development (GO:0072170)	3.22024337
30	metanephric nephron tubule development (GO:0072234)	3.22024337
31	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.17939713
32	peptidyl-histidine modification (GO:0018202)	3.13868519
33	signal peptide processing (GO:0006465)	3.11929167
34	rRNA modification (GO:0000154)	3.11844968
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.11312344
36	ATP synthesis coupled proton transport (GO:0015986)	3.11312344
37	negative regulation of acute inflammatory response (GO:0002674)	3.10581756
38	pseudouridine synthesis (GO:0001522)	3.07929443
39	maturation of 5.8S rRNA (GO:0000460)	3.07417611
40	intracellular protein transmembrane import (GO:0044743)	2.93653741
41	termination of RNA polymerase III transcription (GO:0006386)	2.93597325
42	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.93597325
43	cytochrome complex assembly (GO:0017004)	2.93444620
44	indolalkylamine metabolic process (GO:0006586)	2.91927613
45	protein localization to cilium (GO:0061512)	2.90199962
46	nonmotile primary cilium assembly (GO:0035058)	2.87769023
47	regulation of hexokinase activity (GO:1903299)	2.87353462
48	regulation of glucokinase activity (GO:0033131)	2.87353462
49	C-terminal protein lipidation (GO:0006501)	2.87067749
50	protein prenylation (GO:0018342)	2.85667571
51	prenylation (GO:0097354)	2.85667571
52	piRNA metabolic process (GO:0034587)	2.84458836
53	rRNA methylation (GO:0031167)	2.83574647
54	heme transport (GO:0015886)	2.83241075
55	maturation of SSU-rRNA (GO:0030490)	2.81837721
56	tRNA processing (GO:0008033)	2.80947804
57	removal of superoxide radicals (GO:0019430)	2.80860628
58	cellular response to superoxide (GO:0071451)	2.80860628
59	cellular response to oxygen radical (GO:0071450)	2.80860628
60	mitochondrial RNA metabolic process (GO:0000959)	2.80155284
61	synapsis (GO:0007129)	2.75142570
62	proteasome assembly (GO:0043248)	2.75036178
63	kynurenine metabolic process (GO:0070189)	2.74778036
64	UTP biosynthetic process (GO:0006228)	2.72897352
65	protein-cofactor linkage (GO:0018065)	2.71401526
66	glycerophospholipid catabolic process (GO:0046475)	2.71216252
67	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.71012137
68	positive regulation of respiratory burst (GO:0060267)	2.69270679
69	dentate gyrus development (GO:0021542)	2.68143247
70	tryptophan metabolic process (GO:0006568)	2.67575584
71	negative regulation of protein oligomerization (GO:0032460)	2.66885715
72	UTP metabolic process (GO:0046051)	2.66081335
73	metanephric nephron epithelium development (GO:0072243)	2.65758277
74	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.65259350
75	ubiquinone biosynthetic process (GO:0006744)	2.64690548
76	response to pheromone (GO:0019236)	2.62859113
77	indole-containing compound catabolic process (GO:0042436)	2.60884395
78	indolalkylamine catabolic process (GO:0046218)	2.60884395
79	tryptophan catabolic process (GO:0006569)	2.60884395
80	C-terminal protein amino acid modification (GO:0018410)	2.59285247
81	inner mitochondrial membrane organization (GO:0007007)	2.57620091
82	tRNA metabolic process (GO:0006399)	2.56946299
83	aldehyde catabolic process (GO:0046185)	2.53565555
84	motile cilium assembly (GO:0044458)	2.53459270
85	cilium morphogenesis (GO:0060271)	2.53192995
86	interferon-gamma production (GO:0032609)	2.52847155
87	regulation of cellular respiration (GO:0043457)	2.52238960
88	protein K6-linked ubiquitination (GO:0085020)	2.50671497
89	centriole replication (GO:0007099)	2.50476332
90	DNA methylation involved in gamete generation (GO:0043046)	2.50291916
91	epithelial cilium movement (GO:0003351)	2.48934338
92	electron transport chain (GO:0022900)	2.45535656
93	metanephric epithelium development (GO:0072207)	2.43792793
94	platelet dense granule organization (GO:0060155)	2.42727169
95	substrate-independent telencephalic tangential migration (GO:0021826)	2.42159795
96	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.42159795
97	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.42057814
98	double-strand break repair via homologous recombination (GO:0000724)	2.41348584
99	inositol phosphate catabolic process (GO:0071545)	2.41113283
100	lung epithelium development (GO:0060428)	2.40150618

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.05992354
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.75089453
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.43543418
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.35463930
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.27190112
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.20840141
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.06573269
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.83179351
9	VDR_22108803_ChIP-Seq_LS180_Human	2.67756176
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50805893
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.34898815
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.32659605
13	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.21812678
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.12044443
15	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.01414392
16	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.97586918
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93786398
18	VDR_23849224_ChIP-Seq_CD4+_Human	1.86216024
19	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.83656252
20	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.81699459
21	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80575465
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79987879
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.78695657
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.70726998
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.70704604
26	EZH2_22144423_ChIP-Seq_EOC_Human	1.69160405
27	GBX2_23144817_ChIP-Seq_PC3_Human	1.65573104
28	EWS_26573619_Chip-Seq_HEK293_Human	1.64030617
29	TP53_22573176_ChIP-Seq_HFKS_Human	1.61568132
30	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.53866779
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.53501996
32	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.50929114
33	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.50929114
34	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50073560
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.49946570
36	FUS_26573619_Chip-Seq_HEK293_Human	1.49238644
37	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.47939055
38	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.46788152
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.45367828
40	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.45283118
41	P300_19829295_ChIP-Seq_ESCs_Human	1.43002665
42	IGF1R_20145208_ChIP-Seq_DFB_Human	1.41708273
43	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.40139564
44	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.39511397
45	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.34536750
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.34060515
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.32364257
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25833531
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.24633811
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22085393
51	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21795396
52	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21675092
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.20692646
54	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.19239599
55	NCOR_22424771_ChIP-Seq_293T_Human	1.19132256
56	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.19103865
57	AR_20517297_ChIP-Seq_VCAP_Human	1.18702835
58	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17892913
59	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.17783550
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17705935
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17705935
62	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.16625045
63	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.14278269
64	MYC_19829295_ChIP-Seq_ESCs_Human	1.12204645
65	HOXB7_26014856_ChIP-Seq_BT474_Human	1.11871680
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.11553744
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10517335
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.09236648
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.07804429
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07523588
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05366064
72	AR_25329375_ChIP-Seq_VCAP_Human	1.05042157
73	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.03590451
74	CBP_20019798_ChIP-Seq_JUKART_Human	1.01730192
75	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01730192
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.01508442
77	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01466879
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00810184
79	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.99284412
80	GABP_19822575_ChIP-Seq_HepG2_Human	0.98366583
81	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.98222407
82	STAT3_23295773_ChIP-Seq_U87_Human	0.96117980
83	CDX2_22108803_ChIP-Seq_LS180_Human	0.95584879
84	TAF15_26573619_Chip-Seq_HEK293_Human	0.95350865
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.94920878
86	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.92646326
87	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.92123144
88	TTF2_22483619_ChIP-Seq_HELA_Human	0.92084264
89	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91993971
90	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.91698380
91	NANOG_20526341_ChIP-Seq_ESCs_Human	0.90962852
92	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.90885305
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.89733183
94	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.89049514
95	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.88475944
96	REST_21632747_ChIP-Seq_MESCs_Mouse	0.87572892
97	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.87492203
98	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.86656463
99	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.86430302
100	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.85898467

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002163_abnormal_gland_morphology	3.67450763
2	MP0003787_abnormal_imprinting	3.29846998
3	MP0005379_endocrine/exocrine_gland_phen	3.29323184
4	MP0008877_abnormal_DNA_methylation	3.23829221
5	MP0006292_abnormal_olfactory_placode	3.17584674
6	MP0002102_abnormal_ear_morphology	2.87550356
7	MP0002837_dystrophic_cardiac_calcinosis	2.79496062
8	MP0008875_abnormal_xenobiotic_pharmacok	2.64437854
9	MP0005646_abnormal_pituitary_gland	2.50152889
10	MP0003123_paternal_imprinting	2.40422773
11	MP0000372_irregular_coat_pigmentation	2.35791521
12	MP0002653_abnormal_ependyma_morphology	2.29992289
13	MP0004142_abnormal_muscle_tone	2.23154130
14	MP0003122_maternal_imprinting	2.13726319
15	MP0004885_abnormal_endolymph	2.04708039
16	MP0003283_abnormal_digestive_organ	1.97533127
17	MP0001986_abnormal_taste_sensitivity	1.94961334
18	MP0006072_abnormal_retinal_apoptosis	1.91488766
19	MP0003806_abnormal_nucleotide_metabolis	1.90006418
20	MP0003195_calcinosis	1.86609617
21	MP0002876_abnormal_thyroid_physiology	1.84562377
22	MP0001346_abnormal_lacrimal_gland	1.82692121
23	MP0003646_muscle_fatigue	1.81778971
24	MP0008872_abnormal_physiological_respon	1.80854786
25	MP0005551_abnormal_eye_electrophysiolog	1.75602359
26	MP0003121_genomic_imprinting	1.70062135
27	MP0005084_abnormal_gallbladder_morpholo	1.66588543
28	MP0009379_abnormal_foot_pigmentation	1.64251987
29	MP0010030_abnormal_orbit_morphology	1.56829448
30	MP0001529_abnormal_vocalization	1.55051290
31	MP0005645_abnormal_hypothalamus_physiol	1.54011696
32	MP0002938_white_spotting	1.52143821
33	MP0001968_abnormal_touch/_nociception	1.45958072
34	MP0009046_muscle_twitch	1.41680396
35	MP0004147_increased_porphyrin_level	1.41279572
36	MP0001984_abnormal_olfaction	1.34908704
37	MP0008058_abnormal_DNA_repair	1.30936502
38	MP0005248_abnormal_Harderian_gland	1.30695280
39	MP0008789_abnormal_olfactory_epithelium	1.30386531
40	MP0002272_abnormal_nervous_system	1.30294528
41	MP0005075_abnormal_melanosome_morpholog	1.30183858
42	MP0003693_abnormal_embryo_hatching	1.27723753
43	MP0002138_abnormal_hepatobiliary_system	1.26568864
44	MP0002693_abnormal_pancreas_physiology	1.25099617
45	MP0004133_heterotaxia	1.23768024
46	MP0001905_abnormal_dopamine_level	1.23546260
47	MP0002928_abnormal_bile_duct	1.22089766
48	MP0001485_abnormal_pinna_reflex	1.21232810
49	MP0003878_abnormal_ear_physiology	1.19957587
50	MP0005377_hearing/vestibular/ear_phenot	1.19957587
51	MP0001944_abnormal_pancreas_morphology	1.18579573
52	MP0000013_abnormal_adipose_tissue	1.16945246
53	MP0001501_abnormal_sleep_pattern	1.15091220
54	MP0009745_abnormal_behavioral_response	1.14528279
55	MP0000427_abnormal_hair_cycle	1.14374866
56	MP0002638_abnormal_pupillary_reflex	1.10479945
57	MP0006036_abnormal_mitochondrial_physio	1.09921596
58	MP0005671_abnormal_response_to	1.09611752
59	MP0002557_abnormal_social/conspecific_i	1.07432603
60	MP0003718_maternal_effect	1.04103265
61	MP0004742_abnormal_vestibular_system	1.02299787
62	MP0003786_premature_aging	1.01870809
63	MP0005332_abnormal_amino_acid	1.00853418
64	MP0005253_abnormal_eye_physiology	0.96477896
65	MP0002277_abnormal_respiratory_mucosa	0.94545768
66	MP0005387_immune_system_phenotype	0.94250034
67	MP0001790_abnormal_immune_system	0.94250034
68	MP0002909_abnormal_adrenal_gland	0.93904937
69	MP0004043_abnormal_pH_regulation	0.92860885
70	MP0005389_reproductive_system_phenotype	0.92808234
71	MP0005636_abnormal_mineral_homeostasis	0.91136442
72	MP0005195_abnormal_posterior_eye	0.90496746
73	MP0000631_abnormal_neuroendocrine_gland	0.90284499
74	MP0002733_abnormal_thermal_nociception	0.89307562
75	MP0005499_abnormal_olfactory_system	0.87598285
76	MP0005394_taste/olfaction_phenotype	0.87598285
77	MP0002160_abnormal_reproductive_system	0.85718356
78	MP0001502_abnormal_circadian_rhythm	0.84492540
79	MP0002095_abnormal_skin_pigmentation	0.83909373
80	MP0008775_abnormal_heart_ventricle	0.83895416
81	MP0001970_abnormal_pain_threshold	0.82030425
82	MP0004145_abnormal_muscle_electrophysio	0.81659196
83	MP0003186_abnormal_redox_activity	0.80551194
84	MP0001293_anophthalmia	0.80376792
85	MP0006035_abnormal_mitochondrial_morpho	0.80270285
86	MP0003011_delayed_dark_adaptation	0.79602080
87	MP0003880_abnormal_central_pattern	0.77877625
88	MP0000685_abnormal_immune_system	0.76983668
89	MP0002572_abnormal_emotion/affect_behav	0.76957551
90	MP0002234_abnormal_pharynx_morphology	0.76618342
91	MP0005220_abnormal_exocrine_pancreas	0.76485899
92	MP0003936_abnormal_reproductive_system	0.76458402
93	MP0004924_abnormal_behavior	0.74054141
94	MP0005386_behavior/neurological_phenoty	0.74054141
95	MP0004215_abnormal_myocardial_fiber	0.73557920
96	MP0000015_abnormal_ear_pigmentation	0.73421467
97	MP0002067_abnormal_sensory_capabilities	0.72832644
98	MP0001727_abnormal_embryo_implantation	0.71429616
99	MP0002210_abnormal_sex_determination	0.71049607
100	MP0009780_abnormal_chondrocyte_physiolo	0.69190624

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.33076709
2	Pancreatic fibrosis (HP:0100732)	4.25071960
3	True hermaphroditism (HP:0010459)	4.12464176
4	Molar tooth sign on MRI (HP:0002419)	3.79349341
5	Abnormality of midbrain morphology (HP:0002418)	3.79349341
6	Nephronophthisis (HP:0000090)	3.70190393
7	Large for gestational age (HP:0001520)	3.41609251
8	Absent/shortened dynein arms (HP:0200106)	3.37581003
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.37581003
10	Abnormality of the renal medulla (HP:0100957)	3.29133939
11	Acute necrotizing encephalopathy (HP:0006965)	3.26493959
12	Neoplasm of the adrenal cortex (HP:0100641)	3.25736523
13	Cystic liver disease (HP:0006706)	3.04587503
14	Increased CSF lactate (HP:0002490)	3.01562984
15	Medial flaring of the eyebrow (HP:0010747)	2.97337914
16	Progressive macrocephaly (HP:0004481)	2.94935444
17	Abolished electroretinogram (ERG) (HP:0000550)	2.94489010
18	Mitochondrial inheritance (HP:0001427)	2.93562353
19	Acute encephalopathy (HP:0006846)	2.88550194
20	3-Methylglutaconic aciduria (HP:0003535)	2.88044075
21	Ketoacidosis (HP:0001993)	2.84736186
22	Methylmalonic acidemia (HP:0002912)	2.79789197
23	Abnormality of the labia minora (HP:0012880)	2.78288395
24	Abnormal mitochondria in muscle tissue (HP:0008316)	2.74196973
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72952054
26	Abnormal biliary tract physiology (HP:0012439)	2.71475537
27	Bile duct proliferation (HP:0001408)	2.71475537
28	Pendular nystagmus (HP:0012043)	2.63863131
29	Hyperglycemia (HP:0003074)	2.59853059
30	Abnormality of the renal cortex (HP:0011035)	2.57419594
31	Neoplasm of the adrenal gland (HP:0100631)	2.55592303
32	Hyperinsulinemic hypoglycemia (HP:0000825)	2.55466893
33	Sclerocornea (HP:0000647)	2.55123189
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.54264209
35	Abnormal drinking behavior (HP:0030082)	2.53217037
36	Polydipsia (HP:0001959)	2.53217037
37	Furrowed tongue (HP:0000221)	2.52501026
38	Adrenal hypoplasia (HP:0000835)	2.49778015
39	Agitation (HP:0000713)	2.49526481
40	Hypothermia (HP:0002045)	2.47348834
41	Increased hepatocellular lipid droplets (HP:0006565)	2.45418674
42	Increased serum lactate (HP:0002151)	2.43279099
43	Ketosis (HP:0001946)	2.41642975
44	Lipid accumulation in hepatocytes (HP:0006561)	2.37089580
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36641851
46	Methylmalonic aciduria (HP:0012120)	2.35598834
47	Abnormality of the metopic suture (HP:0005556)	2.34665200
48	Abnormal ciliary motility (HP:0012262)	2.32741532
49	Abnormality of the pancreatic islet cells (HP:0006476)	2.30772470
50	Abnormality of endocrine pancreas physiology (HP:0012093)	2.30772470
51	Attenuation of retinal blood vessels (HP:0007843)	2.29549704
52	Prominent metopic ridge (HP:0005487)	2.29033724
53	Anencephaly (HP:0002323)	2.28064855
54	Congenital stationary night blindness (HP:0007642)	2.28014974
55	Congenital primary aphakia (HP:0007707)	2.27023959
56	Abnormal respiratory epithelium morphology (HP:0012253)	2.26972159
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.26972159
58	Gait imbalance (HP:0002141)	2.26849630
59	Supernumerary spleens (HP:0009799)	2.24485132
60	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.20335984
61	Nephrogenic diabetes insipidus (HP:0009806)	2.18540854
62	Tubular atrophy (HP:0000092)	2.18397500
63	Hepatocellular necrosis (HP:0001404)	2.18229825
64	Decreased central vision (HP:0007663)	2.16408321
65	Stomatitis (HP:0010280)	2.14918197
66	Polyuria (HP:0000103)	2.12601697
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.10134081
68	Hypoplasia of the fovea (HP:0007750)	2.10134081
69	Chronic hepatic failure (HP:0100626)	2.10123574
70	Cerebral edema (HP:0002181)	2.06011358
71	Abnormal pancreas size (HP:0012094)	2.05430927
72	Hepatic necrosis (HP:0002605)	2.05320238
73	Male pseudohermaphroditism (HP:0000037)	2.04678896
74	Colon cancer (HP:0003003)	2.03839159
75	Optic disc pallor (HP:0000543)	2.03347302
76	Asplenia (HP:0001746)	1.99382192
77	Hypoglycemic seizures (HP:0002173)	1.98745806
78	Increased corneal curvature (HP:0100692)	1.98200331
79	Keratoconus (HP:0000563)	1.98200331
80	Postaxial foot polydactyly (HP:0001830)	1.97869264
81	Abnormality of vitamin B metabolism (HP:0004340)	1.96914317
82	Hypomagnesemia (HP:0002917)	1.95848619
83	Congenital hepatic fibrosis (HP:0002612)	1.88527051
84	Congenital, generalized hypertrichosis (HP:0004540)	1.88432987
85	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.87835465
86	Abnormality of alanine metabolism (HP:0010916)	1.87835465
87	Hyperalaninemia (HP:0003348)	1.87835465
88	Pancreatic islet-cell hyperplasia (HP:0004510)	1.86871838
89	Hyperglycinemia (HP:0002154)	1.86543769
90	Insulin-resistant diabetes mellitus (HP:0000831)	1.86173947
91	Lactic acidosis (HP:0003128)	1.84871338
92	Metabolic alkalosis (HP:0200114)	1.76138279
93	Aplasia/hypoplasia of the uterus (HP:0008684)	1.75982395
94	Hyperglycinuria (HP:0003108)	1.75663284
95	Abnormality of abdominal situs (HP:0011620)	1.75639555
96	Abdominal situs inversus (HP:0003363)	1.75639555
97	Chorioretinal atrophy (HP:0000533)	1.74673087
98	Muscular hypotonia of the trunk (HP:0008936)	1.74291671
99	Optic nerve hypoplasia (HP:0000609)	1.71950085
100	Absent thumb (HP:0009777)	1.71827136

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.18019361
2	TAOK3	3.18082285
3	MST4	3.02399334
4	ZAK	2.88421031
5	TSSK6	2.86098165
6	NUAK1	2.85748117
7	TLK1	2.57061203
8	WNK4	2.49789076
9	BMPR1B	2.39595716
10	PINK1	2.21450428
11	MAP3K9	2.18133381
12	ADRBK2	2.09801042
13	EIF2AK1	2.04638265
14	BCR	2.01827858
15	ACVR1B	1.89529470
16	VRK2	1.86699296
17	TRIM28	1.78321659
18	STK39	1.70467450
19	NEK1	1.70260135
20	PLK3	1.67916539
21	PASK	1.65931411
22	MAP4K2	1.60160212
23	GRK1	1.57087413
24	WNK3	1.54712346
25	OXSR1	1.45516927
26	TAF1	1.44115015
27	TXK	1.43039152
28	STK16	1.42371012
29	EIF2AK3	1.34802152
30	PAK3	1.32962248
31	TNIK	1.31556600
32	BCKDK	1.27196061
33	FGFR2	1.23948017
34	BUB1	1.18167361
35	VRK1	1.17568303
36	PHKG2	1.12420780
37	PHKG1	1.12420780
38	SRPK1	1.04201659
39	PLK2	0.98251329
40	MAP2K6	0.98075217
41	STK38L	0.96322957
42	EPHA4	0.93962742
43	INSRR	0.91420829
44	CSNK1G2	0.84381629
45	ADRBK1	0.83899779
46	TNK2	0.83501487
47	DYRK2	0.81547183
48	MKNK2	0.79680868
49	CAMKK2	0.78923400
50	MAP3K12	0.78756999
51	PBK	0.78753501
52	CSNK1G3	0.78180554
53	CDK19	0.75490108
54	TGFBR1	0.74802099
55	CASK	0.74552599
56	CSNK1G1	0.73604152
57	PRKCE	0.72849313
58	STK3	0.68305718
59	CAMK1	0.66560491
60	GRK5	0.65710057
61	NME1	0.65452539
62	CSNK1A1L	0.62474699
63	TEC	0.60441304
64	PRKCG	0.59346970
65	PRKD3	0.59266146
66	PLK4	0.58120396
67	TTK	0.58074173
68	PLK1	0.54545841
69	EIF2AK2	0.54316866
70	ITK	0.54106663
71	IKBKB	0.53980578
72	PRKCH	0.52811166
73	TRPM7	0.49789406
74	MAPK13	0.49070056
75	DAPK2	0.48475861
76	MAP3K4	0.48340831
77	STK24	0.47920996
78	PRKAA2	0.45011964
79	PRKACA	0.43141820
80	NLK	0.37942119
81	PRKCQ	0.37122242
82	TIE1	0.36502613
83	CAMK2D	0.36250910
84	CSNK1A1	0.35520221
85	CAMK2A	0.34581504
86	ATM	0.34555536
87	ATR	0.34191468
88	AURKB	0.34177182
89	PRKCA	0.32194602
90	PTK2B	0.31179451
91	CAMK4	0.28765147
92	CSNK2A2	0.28522099
93	NTRK3	0.28287171
94	STK4	0.28054597
95	KSR1	0.25716939
96	ALK	0.25208036
97	OBSCN	0.25205119
98	FER	0.24437265
99	CSNK1E	0.23803171
100	DAPK3	0.23514316

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	3.56202453
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.01847541
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.92327950
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.74430817
5	RNA polymerase_Homo sapiens_hsa03020	2.51932928
6	Ribosome_Homo sapiens_hsa03010	2.41513612
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.37283820
8	Proteasome_Homo sapiens_hsa03050	2.26682248
9	Parkinsons disease_Homo sapiens_hsa05012	2.23953179
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.23261461
11	Caffeine metabolism_Homo sapiens_hsa00232	2.20132320
12	Sulfur metabolism_Homo sapiens_hsa00920	1.92983117
13	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.89335875
14	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.87939543
15	Collecting duct acid secretion_Homo sapiens_hsa04966	1.86316576
16	Butanoate metabolism_Homo sapiens_hsa00650	1.84898230
17	Propanoate metabolism_Homo sapiens_hsa00640	1.84257032
18	Phototransduction_Homo sapiens_hsa04744	1.78339796
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.78073546
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.74294552
21	Basal transcription factors_Homo sapiens_hsa03022	1.73537302
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.70927307
23	RNA degradation_Homo sapiens_hsa03018	1.70233303
24	Non-homologous end-joining_Homo sapiens_hsa03450	1.66116882
25	One carbon pool by folate_Homo sapiens_hsa00670	1.64494539
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.63326316
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.59796691
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.57810032
29	Selenocompound metabolism_Homo sapiens_hsa00450	1.49797207
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48277051
31	Alzheimers disease_Homo sapiens_hsa05010	1.46622331
32	Huntingtons disease_Homo sapiens_hsa05016	1.46560756
33	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.41264348
34	Homologous recombination_Homo sapiens_hsa03440	1.36449635
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.35030689
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.28470698
37	Peroxisome_Homo sapiens_hsa04146	1.21180986
38	Insulin secretion_Homo sapiens_hsa04911	1.21136840
39	Mismatch repair_Homo sapiens_hsa03430	1.19086315
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.14655967
41	Cardiac muscle contraction_Homo sapiens_hsa04260	1.10733937
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.06444927
43	Purine metabolism_Homo sapiens_hsa00230	1.02423123
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.02146417
45	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.01715002
46	Folate biosynthesis_Homo sapiens_hsa00790	1.00286156
47	Type I diabetes mellitus_Homo sapiens_hsa04940	0.95498301
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.89226023
49	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.87011976
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.84652397
51	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.83185018
52	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81591370
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.81208049
54	Regulation of autophagy_Homo sapiens_hsa04140	0.80501754
55	Fatty acid elongation_Homo sapiens_hsa00062	0.79263913
56	Metabolic pathways_Homo sapiens_hsa01100	0.79259646
57	RNA transport_Homo sapiens_hsa03013	0.77546029
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.70763042
59	Fatty acid degradation_Homo sapiens_hsa00071	0.70470643
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.66972439
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.66882698
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.65161383
63	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.64076461
64	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.63350545
65	Steroid biosynthesis_Homo sapiens_hsa00100	0.63135212
66	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.63112047
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.62607544
68	Nucleotide excision repair_Homo sapiens_hsa03420	0.62448920
69	Asthma_Homo sapiens_hsa05310	0.62184735
70	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.61941257
71	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.61443682
72	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.61173189
73	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.58145615
74	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.57224734
75	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56788616
76	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55780008
77	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.54365238
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.54234712
79	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.53914052
80	Allograft rejection_Homo sapiens_hsa05330	0.52806233
81	Nicotine addiction_Homo sapiens_hsa05033	0.49825125
82	Glutathione metabolism_Homo sapiens_hsa00480	0.49472767
83	Retinol metabolism_Homo sapiens_hsa00830	0.47961189
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.47405452
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47378982
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43590980
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42407656
88	Pyruvate metabolism_Homo sapiens_hsa00620	0.41523417
89	Morphine addiction_Homo sapiens_hsa05032	0.40263202
90	Olfactory transduction_Homo sapiens_hsa04740	0.39934654
91	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.38796381
92	ABC transporters_Homo sapiens_hsa02010	0.34707514
93	Mineral absorption_Homo sapiens_hsa04978	0.33766340
94	Spliceosome_Homo sapiens_hsa03040	0.31980956
95	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31958966
96	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.31262159
97	Rheumatoid arthritis_Homo sapiens_hsa05323	0.30256661
98	Vibrio cholerae infection_Homo sapiens_hsa05110	0.26982402
99	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.26193650
100	Serotonergic synapse_Homo sapiens_hsa04726	0.22955401

RPL3P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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