RPL3P11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.31815406
2positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.03795752
3DNA deamination (GO:0045006)4.97287133
4water-soluble vitamin biosynthetic process (GO:0042364)4.81751850
5regulation of isotype switching to IgG isotypes (GO:0048302)4.64453017
6regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.49723732
7viral transcription (GO:0019083)4.45297230
8translational termination (GO:0006415)4.33835096
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.20593003
10cotranslational protein targeting to membrane (GO:0006613)4.18867670
11protein targeting to ER (GO:0045047)4.12907258
12fucose catabolic process (GO:0019317)4.11607924
13L-fucose metabolic process (GO:0042354)4.11607924
14L-fucose catabolic process (GO:0042355)4.11607924
15energy coupled proton transport, down electrochemical gradient (GO:0015985)4.11379416
16ATP synthesis coupled proton transport (GO:0015986)4.11379416
17GTP biosynthetic process (GO:0006183)4.09320801
18establishment of protein localization to endoplasmic reticulum (GO:0072599)3.98846016
19establishment of protein localization to mitochondrial membrane (GO:0090151)3.98740892
20chaperone-mediated protein transport (GO:0072321)3.98710511
21ribosomal large subunit biogenesis (GO:0042273)3.92802615
22protein localization to endoplasmic reticulum (GO:0070972)3.88574366
23translational elongation (GO:0006414)3.80798888
24behavioral response to nicotine (GO:0035095)3.75310912
25regulation of immunoglobulin secretion (GO:0051023)3.74050631
26protein complex biogenesis (GO:0070271)3.71060821
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70386124
28rRNA modification (GO:0000154)3.67710913
29tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.61269398
30RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.61269398
31UTP biosynthetic process (GO:0006228)3.58996490
32mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.58542373
33ribosomal small subunit biogenesis (GO:0042274)3.53954775
34mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52170775
35mitochondrial respiratory chain complex I assembly (GO:0032981)3.52170775
36NADH dehydrogenase complex assembly (GO:0010257)3.52170775
37response to xenobiotic stimulus (GO:0009410)3.44857938
38rRNA methylation (GO:0031167)3.43209749
39CTP metabolic process (GO:0046036)3.39894704
40CTP biosynthetic process (GO:0006241)3.39894704
41proteasome assembly (GO:0043248)3.39331060
42mitochondrial respiratory chain complex assembly (GO:0033108)3.36317973
43UTP metabolic process (GO:0046051)3.28469336
44viral life cycle (GO:0019058)3.27283980
45translational initiation (GO:0006413)3.25548972
46translation (GO:0006412)3.25394626
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22078041
48protein neddylation (GO:0045116)3.22050171
49cellular protein complex disassembly (GO:0043624)3.20105510
50regulation of chronic inflammatory response (GO:0002676)3.19230986
51pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.16475821
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12990344
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.07406373
54nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03003666
55cellular component biogenesis (GO:0044085)3.02194908
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01946448
57nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.98301939
58pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.98121888
59response to pheromone (GO:0019236)2.97798839
60maturation of SSU-rRNA (GO:0030490)2.96709565
61regulation of regulatory T cell differentiation (GO:0045589)2.95027872
62pseudouridine synthesis (GO:0001522)2.94474229
63ubiquinone biosynthetic process (GO:0006744)2.94325757
64ribonucleoprotein complex biogenesis (GO:0022613)2.94206730
65cellular response to exogenous dsRNA (GO:0071360)2.92780653
66signal peptide processing (GO:0006465)2.91734882
67base-excision repair, AP site formation (GO:0006285)2.89742178
68pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.87627951
69purine nucleoside triphosphate biosynthetic process (GO:0009145)2.86532517
70epithelial cilium movement (GO:0003351)2.86259279
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.85243740
72protein-cofactor linkage (GO:0018065)2.84755201
73preassembly of GPI anchor in ER membrane (GO:0016254)2.83802918
74tRNA processing (GO:0008033)2.82688498
75positive regulation of defense response to virus by host (GO:0002230)2.81928018
76rRNA processing (GO:0006364)2.79384706
77inositol phosphate dephosphorylation (GO:0046855)2.78885049
78phosphorylated carbohydrate dephosphorylation (GO:0046838)2.78885049
79parturition (GO:0007567)2.78875717
80protein polyglutamylation (GO:0018095)2.78841916
81cytidine deamination (GO:0009972)2.77722660
82cytidine metabolic process (GO:0046087)2.77722660
83cytidine catabolic process (GO:0006216)2.77722660
84rRNA metabolic process (GO:0016072)2.76369847
85regulation of podosome assembly (GO:0071801)2.76031166
86phosphatidylinositol acyl-chain remodeling (GO:0036149)2.73444228
87axoneme assembly (GO:0035082)2.72963695
88pyrimidine nucleotide catabolic process (GO:0006244)2.72535250
89pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.70975218
90ribonucleoside triphosphate biosynthetic process (GO:0009201)2.65779502
91protein targeting to membrane (GO:0006612)2.64652957
92pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.62200362
93ubiquinone metabolic process (GO:0006743)2.62068208
94protein complex disassembly (GO:0043241)2.60913465
95inositol phosphate catabolic process (GO:0071545)2.60598108
96electron transport chain (GO:0022900)2.58677912
97negative regulation of acute inflammatory response (GO:0002674)2.57823394
98respiratory electron transport chain (GO:0022904)2.57755840
99maturation of 5.8S rRNA (GO:0000460)2.57204195
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.56826326

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.24852255
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.69117693
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57521737
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.21167176
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86093715
6ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82328712
7EZH2_22144423_ChIP-Seq_EOC_Human2.78286629
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.56170042
9ZNF274_21170338_ChIP-Seq_K562_Hela2.53448757
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.48103368
11VDR_22108803_ChIP-Seq_LS180_Human2.45722420
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.37655047
13VDR_23849224_ChIP-Seq_CD4+_Human2.19554495
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18821413
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18573158
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11106589
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.10252368
18ELK1_19687146_ChIP-ChIP_HELA_Human2.01842264
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93820950
20FOXP3_21729870_ChIP-Seq_TREG_Human1.93626438
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91205490
22SRF_21415370_ChIP-Seq_HL-1_Mouse1.89578921
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.84873139
24MYC_18940864_ChIP-ChIP_HL60_Human1.82661633
25RBPJ_22232070_ChIP-Seq_NCS_Mouse1.79390527
26NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.75348044
27EWS_26573619_Chip-Seq_HEK293_Human1.74140252
28IGF1R_20145208_ChIP-Seq_DFB_Human1.71734581
29TP53_22573176_ChIP-Seq_HFKS_Human1.66892551
30EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65128614
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64712082
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62144635
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.59311509
34FUS_26573619_Chip-Seq_HEK293_Human1.54743662
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.53473676
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47637820
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47247535
38CREB1_15753290_ChIP-ChIP_HEK293T_Human1.40940899
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.40422675
40MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40092122
41IRF1_19129219_ChIP-ChIP_H3396_Human1.36737268
42FOXA1_27270436_Chip-Seq_PROSTATE_Human1.35759309
43FOXA1_25329375_ChIP-Seq_VCAP_Human1.35759309
44P300_19829295_ChIP-Seq_ESCs_Human1.34965051
45TTF2_22483619_ChIP-Seq_HELA_Human1.34649455
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.33583384
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30930978
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30257995
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.28272291
50NFE2_27457419_Chip-Seq_LIVER_Mouse1.25863828
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.22543985
52NCOR_22424771_ChIP-Seq_293T_Human1.20699290
53ELK1_22589737_ChIP-Seq_MCF10A_Human1.19962000
54AR_20517297_ChIP-Seq_VCAP_Human1.19887605
55NANOG_19829295_ChIP-Seq_ESCs_Human1.19367331
56SOX2_19829295_ChIP-Seq_ESCs_Human1.19367331
57GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17828875
58CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16368171
59ZFP57_27257070_Chip-Seq_ESCs_Mouse1.16321763
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16291566
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13280870
62TAF2_19829295_ChIP-Seq_ESCs_Human1.11133956
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10469000
64NANOG_20526341_ChIP-Seq_ESCs_Human1.09510665
65ERA_21632823_ChIP-Seq_H3396_Human1.08440454
66GATA3_21878914_ChIP-Seq_MCF-7_Human1.07766829
67GABP_19822575_ChIP-Seq_HepG2_Human1.06389812
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05746255
69ER_23166858_ChIP-Seq_MCF-7_Human1.04026034
70HOXB7_26014856_ChIP-Seq_BT474_Human1.03443902
71BCAT_22108803_ChIP-Seq_LS180_Human1.03139689
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02228107
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01667574
74EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00533876
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99596944
76CBP_20019798_ChIP-Seq_JUKART_Human0.99596944
77FOXH1_21741376_ChIP-Seq_EPCs_Human0.99190076
78PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99053252
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98108769
80PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97479725
81RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.96947286
82POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96267679
83MYC_19829295_ChIP-Seq_ESCs_Human0.96011884
84IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.95065526
85AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93677271
86MYC_18358816_ChIP-ChIP_MESCs_Mouse0.92933041
87FOXH1_21741376_ChIP-Seq_ESCs_Human0.92550918
88SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.89286956
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89138410
90LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89122457
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89079435
92IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.88239122
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88157397
94GATA3_26560356_Chip-Seq_TH2_Human0.86984947
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86125448
96TCF4_22108803_ChIP-Seq_LS180_Human0.86011741
97UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85466662
98HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84494030
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84417971
100EZH2_27294783_Chip-Seq_NPCs_Mouse0.84274958

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level2.90995477
2MP0008877_abnormal_DNA_methylation2.80700403
3MP0005646_abnormal_pituitary_gland2.74804734
4MP0008875_abnormal_xenobiotic_pharmacok2.63717971
5MP0001873_stomach_inflammation2.56324044
6MP0006292_abnormal_olfactory_placode2.46451023
7MP0001835_abnormal_antigen_presentation2.30340438
8MP0002163_abnormal_gland_morphology2.20113860
9MP0003186_abnormal_redox_activity2.19522964
10MP0003787_abnormal_imprinting2.16851915
11MP0002876_abnormal_thyroid_physiology2.08087571
12MP0008872_abnormal_physiological_respon2.06816052
13MP0005671_abnormal_response_to2.06200113
14MP0005645_abnormal_hypothalamus_physiol2.05713514
15MP0004885_abnormal_endolymph1.98399736
16MP0002653_abnormal_ependyma_morphology1.97538379
17MP0005551_abnormal_eye_electrophysiolog1.92002246
18MP0004142_abnormal_muscle_tone1.88583351
19MP0002138_abnormal_hepatobiliary_system1.83029461
20MP0003122_maternal_imprinting1.79826536
21MP0001986_abnormal_taste_sensitivity1.70465179
22MP0003195_calcinosis1.70346692
23MP0002837_dystrophic_cardiac_calcinosis1.70194222
24MP0005379_endocrine/exocrine_gland_phen1.66533354
25MP0002148_abnormal_hypersensitivity_rea1.59633047
26MP0004782_abnormal_surfactant_physiolog1.57218864
27MP0006072_abnormal_retinal_apoptosis1.55611495
28MP0001968_abnormal_touch/_nociception1.54139336
29MP0009379_abnormal_foot_pigmentation1.52588915
30MP0002736_abnormal_nociception_after1.51483030
31MP0002272_abnormal_nervous_system1.50796458
32MP0001501_abnormal_sleep_pattern1.45614949
33MP0005389_reproductive_system_phenotype1.43314862
34MP0003718_maternal_effect1.42836408
35MP0002938_white_spotting1.41707874
36MP0001348_abnormal_lacrimal_gland1.41282587
37MP0003121_genomic_imprinting1.38454173
38MP0001790_abnormal_immune_system1.37121879
39MP0005387_immune_system_phenotype1.37121879
40MP0005084_abnormal_gallbladder_morpholo1.30191405
41MP0002102_abnormal_ear_morphology1.28501054
42MP0000685_abnormal_immune_system1.28430826
43MP0003011_delayed_dark_adaptation1.26644028
44MP0001293_anophthalmia1.25621401
45MP0004145_abnormal_muscle_electrophysio1.25105299
46MP0000372_irregular_coat_pigmentation1.24773539
47MP0001919_abnormal_reproductive_system1.24572855
48MP0002254_reproductive_system_inflammat1.20219430
49MP0006276_abnormal_autonomic_nervous1.20179658
50MP0001800_abnormal_humoral_immune1.18713985
51MP0003878_abnormal_ear_physiology1.16500165
52MP0005377_hearing/vestibular/ear_phenot1.16500165
53MP0001905_abnormal_dopamine_level1.14639050
54MP0005410_abnormal_fertilization1.14462957
55MP0001440_abnormal_grooming_behavior1.14288896
56MP0000631_abnormal_neuroendocrine_gland1.13589700
57MP0005253_abnormal_eye_physiology1.13176755
58MP0003806_abnormal_nucleotide_metabolis1.12219217
59MP0002277_abnormal_respiratory_mucosa1.11128926
60MP0002095_abnormal_skin_pigmentation1.10986771
61MP0005075_abnormal_melanosome_morpholog1.10694543
62MP0002160_abnormal_reproductive_system1.10656124
63MP0009785_altered_susceptibility_to1.09342503
64MP0009745_abnormal_behavioral_response1.09295208
65MP0003436_decreased_susceptibility_to1.09067910
66MP0008775_abnormal_heart_ventricle1.08897339
67MP0002638_abnormal_pupillary_reflex1.08896018
68MP0001502_abnormal_circadian_rhythm1.06582236
69MP0001663_abnormal_digestive_system1.05316764
70MP0001984_abnormal_olfaction1.04051457
71MP0005167_abnormal_blood-brain_barrier1.02459539
72MP0005195_abnormal_posterior_eye1.02402356
73MP0000613_abnormal_salivary_gland0.98979916
74MP0002405_respiratory_system_inflammati0.98820944
75MP0002733_abnormal_thermal_nociception0.97939223
76MP0004133_heterotaxia0.97704733
77MP0000427_abnormal_hair_cycle0.97551705
78MP0003786_premature_aging0.96403761
79MP0002693_abnormal_pancreas_physiology0.94439783
80MP0005636_abnormal_mineral_homeostasis0.93713124
81MP0003646_muscle_fatigue0.92108662
82MP0009333_abnormal_splenocyte_physiolog0.92028628
83MP0003880_abnormal_central_pattern0.91849281
84MP0005000_abnormal_immune_tolerance0.91203731
85MP0003123_paternal_imprinting0.87925055
86MP0008058_abnormal_DNA_repair0.87398060
87MP0002928_abnormal_bile_duct0.85421245
88MP0003567_abnormal_fetal_cardiomyocyte0.84599762
89MP0005423_abnormal_somatic_nervous0.84089246
90MP0001765_abnormal_ion_homeostasis0.83080444
91MP0003724_increased_susceptibility_to0.79361249
92MP0008789_abnormal_olfactory_epithelium0.79065608
93MP0005174_abnormal_tail_pigmentation0.78799809
94MP0001970_abnormal_pain_threshold0.78511798
95MP0002210_abnormal_sex_determination0.78233115
96MP0005332_abnormal_amino_acid0.77049380
97MP0000230_abnormal_systemic_arterial0.76528356
98MP0002557_abnormal_social/conspecific_i0.76203188
99MP0003936_abnormal_reproductive_system0.74880825
100MP0003879_abnormal_hair_cell0.74842328

Predicted human phenotypes

RankGene SetZ-score
1Molar tooth sign on MRI (HP:0002419)4.50459742
2Abnormality of midbrain morphology (HP:0002418)4.50459742
3Pancreatic fibrosis (HP:0100732)4.15185488
4Pancreatic cysts (HP:0001737)3.67834248
5Stomatitis (HP:0010280)3.61984398
6Acute necrotizing encephalopathy (HP:0006965)3.57203695
7Increased hepatocellular lipid droplets (HP:0006565)3.56310490
8Nephronophthisis (HP:0000090)3.51277827
9Lipid accumulation in hepatocytes (HP:0006561)3.49773876
10Aplasia/Hypoplasia of the spleen (HP:0010451)3.45216191
11Asplenia (HP:0001746)3.29431921
12Dynein arm defect of respiratory motile cilia (HP:0012255)3.29023193
13Absent/shortened dynein arms (HP:0200106)3.29023193
14Acute encephalopathy (HP:0006846)3.23406405
15True hermaphroditism (HP:0010459)3.23214483
16Mitochondrial inheritance (HP:0001427)3.19647204
17Medial flaring of the eyebrow (HP:0010747)3.14672693
18Abnormality of cells of the erythroid lineage (HP:0012130)3.10104601
19Abnormal mitochondria in muscle tissue (HP:0008316)3.09413323
20Progressive macrocephaly (HP:0004481)2.97701502
21Increased CSF lactate (HP:0002490)2.97277087
22Abnormal respiratory motile cilium morphology (HP:0005938)2.95781485
23Abnormal respiratory epithelium morphology (HP:0012253)2.95781485
24Elevated erythrocyte sedimentation rate (HP:0003565)2.92068974
253-Methylglutaconic aciduria (HP:0003535)2.91744472
26Abnormality of the renal medulla (HP:0100957)2.84313536
27Chronic hepatic failure (HP:0100626)2.74217182
28Supernumerary spleens (HP:0009799)2.73124471
29Renal Fanconi syndrome (HP:0001994)2.73121866
30Reticulocytopenia (HP:0001896)2.72817664
31Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.65753298
32Absent rod-and cone-mediated responses on ERG (HP:0007688)2.64830921
33Abnormality of the renal cortex (HP:0011035)2.63141762
34Congenital stationary night blindness (HP:0007642)2.56300870
35IgG deficiency (HP:0004315)2.55957112
36Pendular nystagmus (HP:0012043)2.49116704
37Methylmalonic acidemia (HP:0002912)2.48080952
38Large for gestational age (HP:0001520)2.47512693
39Abnormal rod and cone electroretinograms (HP:0008323)2.42183786
40Abolished electroretinogram (ERG) (HP:0000550)2.41156666
41Increased serum lactate (HP:0002151)2.37885549
42Macrocytic anemia (HP:0001972)2.33707693
43Abnormal number of erythroid precursors (HP:0012131)2.33611654
44Optic disc pallor (HP:0000543)2.33186029
45Gait imbalance (HP:0002141)2.31895511
46Tubular atrophy (HP:0000092)2.31299772
47Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28098147
48Polydipsia (HP:0001959)2.25785151
49Abnormal drinking behavior (HP:0030082)2.25785151
50Congenital primary aphakia (HP:0007707)2.25320766
51Increased intramyocellular lipid droplets (HP:0012240)2.25059930
52Cerebral edema (HP:0002181)2.24985157
53Hepatic necrosis (HP:0002605)2.24366538
54Abnormal pupillary function (HP:0007686)2.18811133
55Hepatocellular necrosis (HP:0001404)2.16080290
56Abnormal ciliary motility (HP:0012262)2.15555677
57Cystic liver disease (HP:0006706)2.15211404
58Median cleft lip (HP:0000161)2.14525654
59Constricted visual fields (HP:0001133)2.14425605
60Congenital hepatic fibrosis (HP:0002612)2.08270812
61Hypomagnesemia (HP:0002917)2.07472579
62Colon cancer (HP:0003003)2.06800983
63Abnormality of renal resorption (HP:0011038)2.05762205
64Nephrogenic diabetes insipidus (HP:0009806)2.04695570
65Type II lissencephaly (HP:0007260)2.04233489
66Abnormality of the labia minora (HP:0012880)2.04168321
67Abnormality of the pons (HP:0007361)2.03768579
68Postaxial foot polydactyly (HP:0001830)2.02911290
69Renal cortical cysts (HP:0000803)2.01291479
70Stenosis of the external auditory canal (HP:0000402)2.00483076
71Exertional dyspnea (HP:0002875)1.99204030
72Increased muscle lipid content (HP:0009058)1.98616256
73Methylmalonic aciduria (HP:0012120)1.98457210
74Male pseudohermaphroditism (HP:0000037)1.97751139
75Attenuation of retinal blood vessels (HP:0007843)1.96379394
76Glycosuria (HP:0003076)1.96049257
77Abnormality of urine glucose concentration (HP:0011016)1.96049257
78Lactic acidosis (HP:0003128)1.95900336
79Abnormal biliary tract physiology (HP:0012439)1.94747223
80Bile duct proliferation (HP:0001408)1.94747223
81Inability to walk (HP:0002540)1.94263896
82Type 2 muscle fiber atrophy (HP:0003554)1.92820062
83Postaxial hand polydactyly (HP:0001162)1.92722540
84Aplasia/hypoplasia of the uterus (HP:0008684)1.92566983
85Septo-optic dysplasia (HP:0100842)1.92120681
86Keratoconus (HP:0000563)1.90061551
87Increased corneal curvature (HP:0100692)1.90061551
88Tachypnea (HP:0002789)1.89808939
89Hyperglycinemia (HP:0002154)1.89328038
90Polyuria (HP:0000103)1.88567349
91Papilledema (HP:0001085)1.86714093
92Exercise intolerance (HP:0003546)1.85937801
93Decreased central vision (HP:0007663)1.84133834
94Absent thumb (HP:0009777)1.81856811
95Confusion (HP:0001289)1.81190720
96Sclerocornea (HP:0000647)1.79108669
97Lethargy (HP:0001254)1.78180317
98Chronic sinusitis (HP:0011109)1.76846088
99Optic nerve coloboma (HP:0000588)1.74072312
100Abnormal respiratory motile cilium physiology (HP:0012261)1.73679236

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE13.23892829
2TNIK3.03118801
3NUAK12.89772414
4TLK12.70732318
5TXK2.58490702
6WNK42.57533577
7FRK2.57301632
8GRK12.51202272
9TAOK32.49879544
10MAP3K122.35012815
11VRK22.26085081
12DYRK22.20935278
13STK162.17263471
14ZAK2.13154659
15ADRBK22.07525406
16WNK31.99959855
17MAP4K21.93933986
18BCKDK1.93385450
19STK391.75569573
20TSSK61.75201163
21TEC1.64521783
22NEK11.59001411
23MST41.55680755
24TAF11.53238253
25NME11.47837852
26BMPR1B1.46211516
27PIK3CA1.34259967
28PHKG21.27876599
29PHKG11.27876599
30ITK1.21526948
31VRK11.18547434
32EIF2AK31.18525440
33MAP2K61.14310042
34PLK31.03995283
35PASK1.03409373
36OXSR11.01382566
37PRKCQ0.99782956
38DAPK20.99482870
39MKNK10.98703371
40ACVR1B0.95895341
41KIT0.94303397
42PRKD30.91942487
43PRKCG0.90972473
44PBK0.84862454
45IKBKB0.83574441
46LIMK10.82027957
47PINK10.81183113
48NLK0.81053111
49PAK30.78768392
50MAPKAPK50.78329730
51PTK2B0.77207935
52DAPK10.75942600
53FES0.73836835
54EIF2AK10.73028748
55TRIM280.71697760
56ADRBK10.70613567
57INSRR0.70510445
58PLK20.66707298
59WNK10.66274507
60PRKCH0.65525885
61TGFBR10.61612225
62NME20.61433014
63EIF2AK20.61146994
64BTK0.60966251
65TNK20.60765485
66MAPK130.60459718
67CSNK1G10.58379079
68CSNK1G20.57116491
69CSNK1A1L0.53982264
70PRKCE0.51682615
71CSNK1G30.51617181
72MAP3K110.50286942
73GRK50.50178165
74MAPK150.48467176
75RPS6KA60.45613056
76CSNK2A20.44298657
77PRKACA0.43058851
78STK30.42863862
79CAMKK20.42524937
80LRRK20.42195976
81GRK70.41361952
82PAK60.41250259
83SYK0.40551669
84MAP4K10.40135943
85CDC70.39964433
86DAPK30.39890709
87PRKCI0.39818986
88LYN0.39580655
89OBSCN0.39556446
90ATR0.38041189
91CDK190.37865463
92MAP3K40.37555229
93MKNK20.36338685
94STK38L0.36219326
95MAP2K20.35274734
96PIM10.34475760
97CSNK2A10.34373631
98LCK0.33562210
99CAMK2D0.33369446
100CAMK2A0.33291325

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.05051590
2Protein export_Homo sapiens_hsa030603.36812834
3Oxidative phosphorylation_Homo sapiens_hsa001902.99043102
4Proteasome_Homo sapiens_hsa030502.97279968
5Asthma_Homo sapiens_hsa053102.50567936
6Parkinsons disease_Homo sapiens_hsa050122.31807965
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.27544977
8Allograft rejection_Homo sapiens_hsa053302.19160703
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.14621641
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.09123542
11RNA polymerase_Homo sapiens_hsa030202.08174025
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.00163009
13Basal transcription factors_Homo sapiens_hsa030221.99945958
14Linoleic acid metabolism_Homo sapiens_hsa005911.98647380
15Autoimmune thyroid disease_Homo sapiens_hsa053201.89212859
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.88242941
17Caffeine metabolism_Homo sapiens_hsa002321.82966557
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.78665330
19Propanoate metabolism_Homo sapiens_hsa006401.77854814
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76313397
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75494043
22Type I diabetes mellitus_Homo sapiens_hsa049401.75265702
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.72343717
24RNA degradation_Homo sapiens_hsa030181.66237848
25Cardiac muscle contraction_Homo sapiens_hsa042601.56061306
26Phototransduction_Homo sapiens_hsa047441.51664789
27Primary immunodeficiency_Homo sapiens_hsa053401.50875851
28Huntingtons disease_Homo sapiens_hsa050161.45825510
29Alzheimers disease_Homo sapiens_hsa050101.45143543
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44621679
31Butanoate metabolism_Homo sapiens_hsa006501.43971850
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39857444
33Maturity onset diabetes of the young_Homo sapiens_hsa049501.29404782
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27912343
35One carbon pool by folate_Homo sapiens_hsa006701.27026198
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.22727575
37Pyrimidine metabolism_Homo sapiens_hsa002401.22713254
38Graft-versus-host disease_Homo sapiens_hsa053321.12927466
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.12127803
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.09968473
41RNA transport_Homo sapiens_hsa030131.09167761
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06329489
43Regulation of autophagy_Homo sapiens_hsa041401.05183990
44Ether lipid metabolism_Homo sapiens_hsa005651.04917512
45Fanconi anemia pathway_Homo sapiens_hsa034601.03707582
46Peroxisome_Homo sapiens_hsa041461.01684992
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.01607544
48Tryptophan metabolism_Homo sapiens_hsa003801.00803590
49Arachidonic acid metabolism_Homo sapiens_hsa005900.96514090
50Sulfur metabolism_Homo sapiens_hsa009200.96382510
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.95044264
52Nitrogen metabolism_Homo sapiens_hsa009100.93551193
53Nucleotide excision repair_Homo sapiens_hsa034200.91198519
54Purine metabolism_Homo sapiens_hsa002300.91063368
55Rheumatoid arthritis_Homo sapiens_hsa053230.85203899
56Hematopoietic cell lineage_Homo sapiens_hsa046400.85025826
57Homologous recombination_Homo sapiens_hsa034400.84103512
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.80292976
59Collecting duct acid secretion_Homo sapiens_hsa049660.79122805
60Fatty acid degradation_Homo sapiens_hsa000710.77095774
61Nicotine addiction_Homo sapiens_hsa050330.75192397
62Selenocompound metabolism_Homo sapiens_hsa004500.69093232
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.68895532
64Fatty acid elongation_Homo sapiens_hsa000620.68682829
65Mismatch repair_Homo sapiens_hsa034300.68574547
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68379896
67Fat digestion and absorption_Homo sapiens_hsa049750.68117805
68Metabolic pathways_Homo sapiens_hsa011000.67514339
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67196192
70Ovarian steroidogenesis_Homo sapiens_hsa049130.65890638
71Pyruvate metabolism_Homo sapiens_hsa006200.64455685
72Sulfur relay system_Homo sapiens_hsa041220.61900959
73Chemical carcinogenesis_Homo sapiens_hsa052040.61007574
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.57582401
75Retinol metabolism_Homo sapiens_hsa008300.57152032
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54835268
77Non-homologous end-joining_Homo sapiens_hsa034500.54660565
78Mineral absorption_Homo sapiens_hsa049780.54237210
79Steroid biosynthesis_Homo sapiens_hsa001000.53833919
80Spliceosome_Homo sapiens_hsa030400.49144713
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47645136
82Insulin secretion_Homo sapiens_hsa049110.46923534
83Glutathione metabolism_Homo sapiens_hsa004800.46737060
84Base excision repair_Homo sapiens_hsa034100.46206512
85beta-Alanine metabolism_Homo sapiens_hsa004100.45048047
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42561421
87Olfactory transduction_Homo sapiens_hsa047400.40576930
88Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40261634
89T cell receptor signaling pathway_Homo sapiens_hsa046600.37649446
90Morphine addiction_Homo sapiens_hsa050320.37230296
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.36724704
92Folate biosynthesis_Homo sapiens_hsa007900.36394630
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.35954656
94Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34480680
95Glycerolipid metabolism_Homo sapiens_hsa005610.32381170
96Fatty acid metabolism_Homo sapiens_hsa012120.31863468
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31231392
98Fatty acid biosynthesis_Homo sapiens_hsa000610.31108782
99Antigen processing and presentation_Homo sapiens_hsa046120.29895052
100Vitamin digestion and absorption_Homo sapiens_hsa049770.29196356

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