RPL3P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.67369025
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.50721950
3ATP synthesis coupled proton transport (GO:0015986)4.31259151
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.31259151
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.09094150
6cytidine deamination (GO:0009972)4.03698085
7cytidine metabolic process (GO:0046087)4.03698085
8cytidine catabolic process (GO:0006216)4.03698085
9ribosomal small subunit assembly (GO:0000028)3.74274983
10regulation of regulatory T cell differentiation (GO:0045589)3.69765255
11water-soluble vitamin biosynthetic process (GO:0042364)3.59226566
12positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.55352925
13pyrimidine ribonucleoside catabolic process (GO:0046133)3.55143220
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49449134
15RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41467377
16tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41467377
17negative T cell selection (GO:0043383)3.38940716
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38617940
19cytochrome complex assembly (GO:0017004)3.35700767
20respiratory chain complex IV assembly (GO:0008535)3.35673540
21regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.29420014
22protein complex biogenesis (GO:0070271)3.28956715
23positive regulation of T cell mediated cytotoxicity (GO:0001916)3.21728059
24respiratory electron transport chain (GO:0022904)3.16481692
25electron transport chain (GO:0022900)3.15221171
26regulation of T cell receptor signaling pathway (GO:0050856)3.13848384
27regulation of isotype switching to IgG isotypes (GO:0048302)3.13426236
28positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10512048
29regulation of immunoglobulin secretion (GO:0051023)3.10040686
30proteasome assembly (GO:0043248)3.09736587
31response to pheromone (GO:0019236)3.08879101
32positive regulation of defense response to virus by host (GO:0002230)3.07591148
33protein neddylation (GO:0045116)3.07510632
34regulation of memory T cell differentiation (GO:0043380)3.07369730
35regulation of T cell mediated cytotoxicity (GO:0001914)2.99635239
36positive regulation of prostaglandin secretion (GO:0032308)2.99412752
37mitochondrial respiratory chain complex assembly (GO:0033108)2.97783380
38adenosine metabolic process (GO:0046085)2.95751729
39somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.94074927
40isotype switching (GO:0045190)2.94074927
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.94074927
42iron-sulfur cluster assembly (GO:0016226)2.88523146
43metallo-sulfur cluster assembly (GO:0031163)2.88523146
44regulation of cellular amino acid metabolic process (GO:0006521)2.87562178
45regulation of chronic inflammatory response (GO:0002676)2.86471872
46sleep (GO:0030431)2.86345340
47termination of RNA polymerase III transcription (GO:0006386)2.86056442
48transcription elongation from RNA polymerase III promoter (GO:0006385)2.86056442
49platelet dense granule organization (GO:0060155)2.85834195
50indolalkylamine metabolic process (GO:0006586)2.82181933
51negative thymic T cell selection (GO:0045060)2.82114714
52peptidyl-histidine modification (GO:0018202)2.80740014
53L-fucose catabolic process (GO:0042355)2.80322639
54fucose catabolic process (GO:0019317)2.80322639
55L-fucose metabolic process (GO:0042354)2.80322639
56positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.80162304
57mannosylation (GO:0097502)2.80148144
58negative regulation of mast cell activation (GO:0033004)2.79449863
59protein-cofactor linkage (GO:0018065)2.78762573
60tryptophan metabolic process (GO:0006568)2.78061091
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.77435894
62tryptophan catabolic process (GO:0006569)2.75410793
63indole-containing compound catabolic process (GO:0042436)2.75410793
64indolalkylamine catabolic process (GO:0046218)2.75410793
65signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.73576458
66signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.73576458
67signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.73576458
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73520710
69preassembly of GPI anchor in ER membrane (GO:0016254)2.73481599
70pseudouridine synthesis (GO:0001522)2.73102651
71maturation of 5.8S rRNA (GO:0000460)2.71300345
72proton transport (GO:0015992)2.71216640
73cullin deneddylation (GO:0010388)2.71012617
74cellular ketone body metabolic process (GO:0046950)2.70982382
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.70629221
76rRNA modification (GO:0000154)2.70596089
77cellular response to interleukin-15 (GO:0071350)2.69603983
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68777435
79hydrogen transport (GO:0006818)2.68224959
80hydrogen ion transmembrane transport (GO:1902600)2.67980692
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.67746802
82regulation of leukocyte mediated cytotoxicity (GO:0001910)2.66628544
83signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65077808
84intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65077808
85mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62292530
86mitochondrial respiratory chain complex I assembly (GO:0032981)2.62292530
87NADH dehydrogenase complex assembly (GO:0010257)2.62292530
88tRNA processing (GO:0008033)2.61583393
89regulation of gamma-delta T cell differentiation (GO:0045586)2.59802539
90S-adenosylmethionine metabolic process (GO:0046500)2.59285292
91kynurenine metabolic process (GO:0070189)2.56276195
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.56031244
93protein deneddylation (GO:0000338)2.55645584
94regulation of alpha-beta T cell proliferation (GO:0046640)2.55033593
95positive regulation of gamma-delta T cell activation (GO:0046645)2.54786582
96RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.54351395
97signal transduction involved in DNA integrity checkpoint (GO:0072401)2.54208052
98signal transduction involved in DNA damage checkpoint (GO:0072422)2.54208052
99positive T cell selection (GO:0043368)2.54024782
100behavioral response to nicotine (GO:0035095)2.53878278

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.05429247
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.85313125
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.23212090
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.03541644
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.91717522
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.87103883
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82633963
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78433354
9VDR_22108803_ChIP-Seq_LS180_Human2.70645221
10VDR_23849224_ChIP-Seq_CD4+_Human2.70068510
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.68273480
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.53148931
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48015507
14ZNF274_21170338_ChIP-Seq_K562_Hela2.46773478
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37362090
16FLI1_27457419_Chip-Seq_LIVER_Mouse2.36307093
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.36091174
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.33942914
19NOTCH1_21737748_ChIP-Seq_TLL_Human2.30764980
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25136010
21FOXP3_21729870_ChIP-Seq_TREG_Human2.11692759
22ELK1_19687146_ChIP-ChIP_HELA_Human2.07811830
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04783121
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87882916
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.84317621
26GATA3_26560356_Chip-Seq_TH2_Human1.82543733
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.81007012
28PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.80528470
29MYC_18940864_ChIP-ChIP_HL60_Human1.74562118
30IRF8_21731497_ChIP-ChIP_J774_Mouse1.73983447
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63319940
32TP53_22573176_ChIP-Seq_HFKS_Human1.60239231
33MYB_26560356_Chip-Seq_TH2_Human1.56870345
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55957682
35IGF1R_20145208_ChIP-Seq_DFB_Human1.53817288
36CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53100017
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.48719992
38AR_20517297_ChIP-Seq_VCAP_Human1.48485523
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.46800273
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.46800273
41RUNX_20019798_ChIP-Seq_JUKART_Human1.45649905
42EWS_26573619_Chip-Seq_HEK293_Human1.41255351
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.38730766
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38535486
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37641056
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34392314
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27869563
48CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25363790
49NFE2_27457419_Chip-Seq_LIVER_Mouse1.25132075
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.24383053
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22899574
52GATA3_27048872_Chip-Seq_THYMUS_Human1.21844042
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20762814
54SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20321911
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.19788919
56TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.18921141
57NCOR_22424771_ChIP-Seq_293T_Human1.18025878
58NANOG_19829295_ChIP-Seq_ESCs_Human1.16317577
59SOX2_19829295_ChIP-Seq_ESCs_Human1.16317577
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15701086
61PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.15665852
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.13688163
63ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11218485
64NANOG_20526341_ChIP-Seq_ESCs_Human1.11204355
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.11075321
66PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.11061930
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10667068
68PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09297106
69ERG_20517297_ChIP-Seq_VCAP_Human1.08490450
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08401996
71AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07999506
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.07914786
73IRF1_19129219_ChIP-ChIP_H3396_Human1.07409385
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07144838
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.06860004
76P300_19829295_ChIP-Seq_ESCs_Human1.06075416
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04903430
78CBP_20019798_ChIP-Seq_JUKART_Human1.04692505
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04692505
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04360435
81FUS_26573619_Chip-Seq_HEK293_Human1.04116872
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03444209
83GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02748499
84MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02552634
85GABP_19822575_ChIP-Seq_HepG2_Human1.01771882
86MYC_19829295_ChIP-Seq_ESCs_Human1.01428230
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01399026
88GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00185406
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00142296
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00140415
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99888808
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99267142
93STAT1_20625510_ChIP-Seq_HELA_Human0.98855391
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98847883
95GATA3_26560356_Chip-Seq_TH1_Human0.98815730
96GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96724262
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.96050083
98DCP1A_22483619_ChIP-Seq_HELA_Human0.95914026
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.94581454
100ER_23166858_ChIP-Seq_MCF-7_Human0.93934694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.25880784
2MP0001835_abnormal_antigen_presentation2.97750815
3MP0002837_dystrophic_cardiac_calcinosis2.35419699
4MP0003195_calcinosis2.33725729
5MP0008875_abnormal_xenobiotic_pharmacok2.28398136
6MP0003763_abnormal_thymus_physiology2.27606527
7MP0006072_abnormal_retinal_apoptosis2.24385588
8MP0002138_abnormal_hepatobiliary_system2.23103188
9MP0009785_altered_susceptibility_to2.18337977
10MP0000685_abnormal_immune_system2.16906588
11MP0002876_abnormal_thyroid_physiology2.14639127
12MP0008872_abnormal_physiological_respon2.01363369
13MP0005075_abnormal_melanosome_morpholog2.00604060
14MP0005000_abnormal_immune_tolerance1.97137818
15MP0008877_abnormal_DNA_methylation1.96496827
16MP0001800_abnormal_humoral_immune1.96314874
17MP0002166_altered_tumor_susceptibility1.96166010
18MP0002148_abnormal_hypersensitivity_rea1.90464666
19MP0004147_increased_porphyrin_level1.88052461
20MP0002102_abnormal_ear_morphology1.87422537
21MP0005084_abnormal_gallbladder_morpholo1.71619254
22MP0005646_abnormal_pituitary_gland1.71582412
23MP0005645_abnormal_hypothalamus_physiol1.71514161
24MP0009333_abnormal_splenocyte_physiolog1.71144904
25MP0001968_abnormal_touch/_nociception1.69912829
26MP0003011_delayed_dark_adaptation1.69739929
27MP0002723_abnormal_immune_serum1.68466584
28MP0002006_tumorigenesis1.67898523
29MP0005551_abnormal_eye_electrophysiolog1.63472652
30MP0001819_abnormal_immune_cell1.63264312
31MP0002420_abnormal_adaptive_immunity1.62497849
32MP0005387_immune_system_phenotype1.59415564
33MP0001790_abnormal_immune_system1.59415564
34MP0001986_abnormal_taste_sensitivity1.56471230
35MP0003724_increased_susceptibility_to1.56123150
36MP0000372_irregular_coat_pigmentation1.52351136
37MP0005360_urolithiasis1.50977585
38MP0003786_premature_aging1.50575291
39MP0002452_abnormal_antigen_presenting1.49517326
40MP0005379_endocrine/exocrine_gland_phen1.47441931
41MP0004885_abnormal_endolymph1.46263701
42MP0005253_abnormal_eye_physiology1.46211391
43MP0003866_abnormal_defecation1.45491069
44MP0002736_abnormal_nociception_after1.43819063
45MP0008058_abnormal_DNA_repair1.43696122
46MP0001919_abnormal_reproductive_system1.42508046
47MP0002163_abnormal_gland_morphology1.42033667
48MP0003646_muscle_fatigue1.37541576
49MP0003878_abnormal_ear_physiology1.36883097
50MP0005377_hearing/vestibular/ear_phenot1.36883097
51MP0005025_abnormal_response_to1.33213924
52MP0001501_abnormal_sleep_pattern1.32814915
53MP0004145_abnormal_muscle_electrophysio1.28673407
54MP0005167_abnormal_blood-brain_barrier1.25654811
55MP0003436_decreased_susceptibility_to1.25410410
56MP0000689_abnormal_spleen_morphology1.19264496
57MP0005389_reproductive_system_phenotype1.17583819
58MP0006036_abnormal_mitochondrial_physio1.17011216
59MP0000716_abnormal_immune_system1.16668139
60MP0009764_decreased_sensitivity_to1.15990202
61MP0003806_abnormal_nucleotide_metabolis1.13460590
62MP0002398_abnormal_bone_marrow1.10779395
63MP0004043_abnormal_pH_regulation1.10469862
64MP0001905_abnormal_dopamine_level1.10015033
65MP0001845_abnormal_inflammatory_respons1.07605530
66MP0003045_fibrosis1.06312534
67MP0005636_abnormal_mineral_homeostasis1.05725957
68MP0001984_abnormal_olfaction1.05336045
69MP0002405_respiratory_system_inflammati1.05308244
70MP0001764_abnormal_homeostasis1.05132322
71MP0010155_abnormal_intestine_physiology1.04716795
72MP0005410_abnormal_fertilization1.03192351
73MP0003252_abnormal_bile_duct1.02100372
74MP0000703_abnormal_thymus_morphology1.01660549
75MP0001873_stomach_inflammation1.01568398
76MP0003186_abnormal_redox_activity1.00636381
77MP0002693_abnormal_pancreas_physiology1.00310546
78MP0000465_gastrointestinal_hemorrhage0.99772461
79MP0004142_abnormal_muscle_tone0.98665796
80MP0005332_abnormal_amino_acid0.96394178
81MP0002722_abnormal_immune_system0.95060684
82MP0002638_abnormal_pupillary_reflex0.92721476
83MP0008469_abnormal_protein_level0.91718963
84MP0006082_CNS_inflammation0.91010671
85MP0002429_abnormal_blood_cell0.88398058
86MP0002419_abnormal_innate_immunity0.87960536
87MP0010329_abnormal_lipoprotein_level0.87571623
88MP0001765_abnormal_ion_homeostasis0.85834831
89MP0008995_early_reproductive_senescence0.85074307
90MP0002933_joint_inflammation0.83292556
91MP0009643_abnormal_urine_homeostasis0.83063611
92MP0009745_abnormal_behavioral_response0.81463285
93MP0002277_abnormal_respiratory_mucosa0.80629975
94MP0005085_abnormal_gallbladder_physiolo0.80076299
95MP0003880_abnormal_central_pattern0.78871194
96MP0008775_abnormal_heart_ventricle0.78561954
97MP0003718_maternal_effect0.75041931
98MP0002095_abnormal_skin_pigmentation0.73896748
99MP0002272_abnormal_nervous_system0.72925248
100MP0001533_abnormal_skeleton_physiology0.71582091

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.52492943
2Congenital stationary night blindness (HP:0007642)3.79819962
3Stomatitis (HP:0010280)3.73863685
4Mitochondrial inheritance (HP:0001427)3.72908927
53-Methylglutaconic aciduria (HP:0003535)3.69100259
6Hepatocellular necrosis (HP:0001404)3.57445291
7Severe combined immunodeficiency (HP:0004430)3.56903913
8Acute necrotizing encephalopathy (HP:0006965)3.47510988
9Increased CSF lactate (HP:0002490)3.44109974
10Hepatic necrosis (HP:0002605)3.35354120
11Elevated erythrocyte sedimentation rate (HP:0003565)3.31870581
12Pancreatic cysts (HP:0001737)3.24592842
13Increased hepatocellular lipid droplets (HP:0006565)3.22857796
14Lipid accumulation in hepatocytes (HP:0006561)3.21740127
15Abnormal mitochondria in muscle tissue (HP:0008316)3.09669760
16Renal cortical cysts (HP:0000803)3.05022685
17Progressive macrocephaly (HP:0004481)3.05004305
18Acute encephalopathy (HP:0006846)2.89257753
19Abnormality of the renal cortex (HP:0011035)2.87635496
20Thyroiditis (HP:0100646)2.76351664
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73147033
22Renal Fanconi syndrome (HP:0001994)2.70735359
23Aplastic anemia (HP:0001915)2.69662232
24Abnormality of T cells (HP:0002843)2.66615061
25T lymphocytopenia (HP:0005403)2.66379389
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.66189421
27Combined immunodeficiency (HP:0005387)2.62670052
28Abnormality of T cell number (HP:0011839)2.61701099
29Congenital, generalized hypertrichosis (HP:0004540)2.59655312
30Pancreatic fibrosis (HP:0100732)2.59556665
31Increased intramyocellular lipid droplets (HP:0012240)2.56414900
32Abnormality of B cell number (HP:0010975)2.55959383
33Type II lissencephaly (HP:0007260)2.55641817
34Abolished electroretinogram (ERG) (HP:0000550)2.55160421
35Methylmalonic acidemia (HP:0002912)2.54114990
36Abnormal rod and cone electroretinograms (HP:0008323)2.53948353
37Increased serum lactate (HP:0002151)2.47834090
38Hypoproteinemia (HP:0003075)2.47501467
39Abnormality of T cell physiology (HP:0011840)2.46524670
40Abnormality of midbrain morphology (HP:0002418)2.46392936
41Molar tooth sign on MRI (HP:0002419)2.46392936
42Prostate neoplasm (HP:0100787)2.45483165
43Polydipsia (HP:0001959)2.39684970
44Abnormal drinking behavior (HP:0030082)2.39684970
45Abnormality of the prostate (HP:0008775)2.39568002
46B lymphocytopenia (HP:0010976)2.37557706
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37543116
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37543116
49Stomach cancer (HP:0012126)2.37040900
50True hermaphroditism (HP:0010459)2.36330513
51Lactic acidosis (HP:0003128)2.35600098
52Panhypogammaglobulinemia (HP:0003139)2.34839297
53Cerebral edema (HP:0002181)2.33770416
54Increased IgM level (HP:0003496)2.33055028
55Increased muscle lipid content (HP:0009058)2.24336934
56Methylmalonic aciduria (HP:0012120)2.22848849
57Pancytopenia (HP:0001876)2.21949016
58Optic disc pallor (HP:0000543)2.21692616
59Type 2 muscle fiber atrophy (HP:0003554)2.17986179
60Nephronophthisis (HP:0000090)2.17527588
61Abnormality of eosinophils (HP:0001879)2.15666953
62Aplasia/hypoplasia of the uterus (HP:0008684)2.14665020
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13836119
64Dicarboxylic aciduria (HP:0003215)2.13836119
65Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08655138
66Exertional dyspnea (HP:0002875)2.04590699
67Medial flaring of the eyebrow (HP:0010747)2.02874897
68Attenuation of retinal blood vessels (HP:0007843)2.02132905
69Ketosis (HP:0001946)2.02024722
70Glycosuria (HP:0003076)1.99675811
71Abnormality of urine glucose concentration (HP:0011016)1.99675811
72Polyuria (HP:0000103)1.99496932
73Lethargy (HP:0001254)1.99216400
74Myositis (HP:0100614)1.97898144
75Colon cancer (HP:0003003)1.95323507
76IgM deficiency (HP:0002850)1.92350689
77Respiratory failure (HP:0002878)1.91976143
78Absent thumb (HP:0009777)1.91736815
79Pustule (HP:0200039)1.91530024
80Ketoacidosis (HP:0001993)1.91214214
81Abnormality of the pons (HP:0007361)1.90541656
82Large for gestational age (HP:0001520)1.89970053
83Decreased electroretinogram (ERG) amplitude (HP:0000654)1.87047001
84Type I transferrin isoform profile (HP:0003642)1.86003326
85Abnormal number of erythroid precursors (HP:0012131)1.83681807
86Optic neuritis (HP:0100653)1.82507487
87Retrobulbar optic neuritis (HP:0100654)1.82507487
88Abnormality of the renal medulla (HP:0100957)1.81194909
89Hypothermia (HP:0002045)1.80790012
90Muscle fiber atrophy (HP:0100295)1.79504288
91Generalized aminoaciduria (HP:0002909)1.79394443
92Hyperglycinuria (HP:0003108)1.77929402
93Neutropenia (HP:0001875)1.77907616
94Abnormal protein glycosylation (HP:0012346)1.77860636
95Abnormal glycosylation (HP:0012345)1.77860636
96Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.77860636
97Abnormal protein N-linked glycosylation (HP:0012347)1.77860636
98Severe muscular hypotonia (HP:0006829)1.76968975
99Abnormality of vitamin B metabolism (HP:0004340)1.76834382
100Abnormal biliary tract physiology (HP:0012439)1.72496409

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.91911592
2MAP4K23.17662844
3ZAK3.17431332
4TAOK32.86265191
5VRK22.84649387
6TLK12.76108983
7NUAK12.59727191
8GRK12.45067411
9ADRBK22.37640347
10FRK2.28741504
11KDR2.14030730
12MST41.97245014
13GRK61.87422928
14BCKDK1.85765652
15TESK21.80766168
16ITK1.73145569
17TEC1.60569807
18MAP4K11.58176213
19BMPR1B1.56304422
20WNK41.53473113
21PASK1.45917625
22STK161.44018926
23TSSK61.43619994
24PINK11.42898559
25VRK11.42533283
26MAP3K121.38807207
27EIF2AK31.31667239
28IKBKB1.26845174
29CDK191.22060092
30FES1.21379926
31STK391.21273051
32NME11.20527757
33OXSR11.16475032
34SYK1.14222671
35PHKG11.13942029
36PHKG21.13942029
37MUSK1.13605441
38LIMK11.07697967
39WNK31.05468112
40BTK1.01992914
41SCYL21.00463778
42IKBKE0.99122983
43TIE10.97471059
44INSRR0.95609079
45EIF2AK20.93810412
46MAP2K60.92298113
47MAP3K140.84241543
48MAPKAPK30.81540628
49LCK0.79079665
50TNK20.77792197
51PRKCQ0.77339810
52KIT0.76861067
53PLK30.75162530
54RPS6KA50.74712563
55TBK10.74326792
56RPS6KA40.73493794
57DAPK10.73388545
58TAF10.73103257
59LYN0.72641968
60BUB10.72370487
61DAPK20.71689275
62CSNK1G30.69673004
63ZAP700.68094510
64SRPK10.65170268
65CDK80.64773116
66CAMKK20.62607872
67ERBB30.62443623
68MAP2K20.61616219
69MYLK0.61360819
70CLK10.60361285
71EPHA30.60295646
72NLK0.58133831
73TRIM280.56573124
74ADRBK10.56334345
75CSNK1G10.56177085
76PLK20.53809430
77CSNK1A1L0.52126868
78GRK50.50841408
79EIF2AK10.50525861
80TESK10.49797514
81PLK40.49778763
82MAP3K40.49550514
83CSF1R0.47766448
84IGF1R0.47266160
85GRK70.46847321
86TGFBR10.44840205
87BMPR20.44722259
88MAPK130.44647038
89IRAK40.43824189
90CSNK1G20.42283885
91MAPKAPK50.40525488
92FLT30.40214448
93DYRK20.36949026
94CSK0.36274499
95PIM10.35494014
96ABL10.34764633
97HCK0.33508916
98PBK0.33091152
99PTK2B0.32905893
100ACVR1B0.32623486

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.66375258
2Primary immunodeficiency_Homo sapiens_hsa053403.38693804
3Oxidative phosphorylation_Homo sapiens_hsa001903.35221717
4Parkinsons disease_Homo sapiens_hsa050122.61937704
5Ribosome_Homo sapiens_hsa030102.61373400
6Protein export_Homo sapiens_hsa030602.48781056
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.46903951
8RNA polymerase_Homo sapiens_hsa030202.44395617
9Allograft rejection_Homo sapiens_hsa053302.43542041
10Asthma_Homo sapiens_hsa053102.33077848
11Autoimmune thyroid disease_Homo sapiens_hsa053202.27227680
12Graft-versus-host disease_Homo sapiens_hsa053322.14711530
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.13979917
14Type I diabetes mellitus_Homo sapiens_hsa049402.01723787
15Caffeine metabolism_Homo sapiens_hsa002321.97220563
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79031933
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67851758
18Antigen processing and presentation_Homo sapiens_hsa046121.60732593
19Alzheimers disease_Homo sapiens_hsa050101.60677530
20Huntingtons disease_Homo sapiens_hsa050161.55829177
21Sulfur metabolism_Homo sapiens_hsa009201.55584254
22Phototransduction_Homo sapiens_hsa047441.54148156
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.51755145
24Linoleic acid metabolism_Homo sapiens_hsa005911.50755593
25Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46023964
26Homologous recombination_Homo sapiens_hsa034401.44874101
27Tryptophan metabolism_Homo sapiens_hsa003801.39471364
28Nitrogen metabolism_Homo sapiens_hsa009101.38354667
29Propanoate metabolism_Homo sapiens_hsa006401.38285569
30RNA degradation_Homo sapiens_hsa030181.35183409
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33891532
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31724559
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.30522582
34Hematopoietic cell lineage_Homo sapiens_hsa046401.27538742
35Peroxisome_Homo sapiens_hsa041461.26142924
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.22921543
37Butanoate metabolism_Homo sapiens_hsa006501.21204325
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20110550
39Rheumatoid arthritis_Homo sapiens_hsa053231.16247975
40Basal transcription factors_Homo sapiens_hsa030221.15857727
41Fanconi anemia pathway_Homo sapiens_hsa034601.09829377
42One carbon pool by folate_Homo sapiens_hsa006701.09345911
43Cardiac muscle contraction_Homo sapiens_hsa042601.07178028
44Pyrimidine metabolism_Homo sapiens_hsa002401.04705355
45Purine metabolism_Homo sapiens_hsa002301.04584492
46Mismatch repair_Homo sapiens_hsa034301.02129628
47T cell receptor signaling pathway_Homo sapiens_hsa046601.01035393
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98719200
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.93998508
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.93997410
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.90971538
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90755954
53Chemical carcinogenesis_Homo sapiens_hsa052040.89798140
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86074637
55Collecting duct acid secretion_Homo sapiens_hsa049660.82892888
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.82515278
57Folate biosynthesis_Homo sapiens_hsa007900.81148791
58Nucleotide excision repair_Homo sapiens_hsa034200.79298577
59Arachidonic acid metabolism_Homo sapiens_hsa005900.78568362
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77252020
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.74786985
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71769823
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71441505
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.70490079
65Retinol metabolism_Homo sapiens_hsa008300.70413322
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69352750
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67669775
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65342437
69Metabolic pathways_Homo sapiens_hsa011000.63081381
70Spliceosome_Homo sapiens_hsa030400.62648886
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62457786
72Regulation of autophagy_Homo sapiens_hsa041400.62113835
73Selenocompound metabolism_Homo sapiens_hsa004500.62096624
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60807385
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59039094
76Ether lipid metabolism_Homo sapiens_hsa005650.56274353
77RNA transport_Homo sapiens_hsa030130.55995014
78Olfactory transduction_Homo sapiens_hsa047400.54876575
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.53982018
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.51873327
81Vitamin B6 metabolism_Homo sapiens_hsa007500.51789160
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49594828
83Fat digestion and absorption_Homo sapiens_hsa049750.49536333
84Measles_Homo sapiens_hsa051620.48203665
85Taste transduction_Homo sapiens_hsa047420.45278747
86Fatty acid elongation_Homo sapiens_hsa000620.43809900
87ABC transporters_Homo sapiens_hsa020100.43681150
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43431780
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40461826
90beta-Alanine metabolism_Homo sapiens_hsa004100.39005564
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.35945746
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35204970
93Sulfur relay system_Homo sapiens_hsa041220.34564999
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32210477
95Viral myocarditis_Homo sapiens_hsa054160.32072994
96DNA replication_Homo sapiens_hsa030300.30645131
97Morphine addiction_Homo sapiens_hsa050320.29870085
98Herpes simplex infection_Homo sapiens_hsa051680.29410797
99Base excision repair_Homo sapiens_hsa034100.28354946
100Glutathione metabolism_Homo sapiens_hsa004800.27727540

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