RPL3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.77157339
2tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.44961393
3RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.44961393
4ATP synthesis coupled proton transport (GO:0015986)4.10659857
5energy coupled proton transport, down electrochemical gradient (GO:0015985)4.10659857
6protein neddylation (GO:0045116)3.98426998
7nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.91291486
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.82867978
9chaperone-mediated protein transport (GO:0072321)3.81775812
10cytidine metabolic process (GO:0046087)3.79505453
11cytidine catabolic process (GO:0006216)3.79505453
12cytidine deamination (GO:0009972)3.79505453
13exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.79179123
14water-soluble vitamin biosynthetic process (GO:0042364)3.71222040
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.65745692
16protein deneddylation (GO:0000338)3.63296822
17proteasome assembly (GO:0043248)3.62167570
18respiratory chain complex IV assembly (GO:0008535)3.56135063
19protein complex biogenesis (GO:0070271)3.55363317
20cullin deneddylation (GO:0010388)3.53927173
21mitochondrial respiratory chain complex assembly (GO:0033108)3.37047732
22regulation of cellular amino acid metabolic process (GO:0006521)3.34636532
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.30003382
24cytochrome complex assembly (GO:0017004)3.29364520
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.27919544
26pyrimidine ribonucleoside catabolic process (GO:0046133)3.25567478
27platelet dense granule organization (GO:0060155)3.18781109
28DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17014347
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.11599176
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.11599176
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.11599176
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.11378610
33RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11181863
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.10135587
35NADH dehydrogenase complex assembly (GO:0010257)3.10135587
36mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10135587
37L-fucose catabolic process (GO:0042355)3.09189960
38fucose catabolic process (GO:0019317)3.09189960
39L-fucose metabolic process (GO:0042354)3.09189960
40ribosomal small subunit assembly (GO:0000028)3.05254555
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.04651358
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.04651358
43positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00827156
44transcription elongation from RNA polymerase III promoter (GO:0006385)3.00571403
45termination of RNA polymerase III transcription (GO:0006386)3.00571403
46iron-sulfur cluster assembly (GO:0016226)3.00035692
47metallo-sulfur cluster assembly (GO:0031163)3.00035692
48DNA double-strand break processing (GO:0000729)2.97417070
49response to pheromone (GO:0019236)2.96210833
50pseudouridine synthesis (GO:0001522)2.93020181
51preassembly of GPI anchor in ER membrane (GO:0016254)2.92924128
52mannosylation (GO:0097502)2.92447177
53signal transduction involved in cell cycle checkpoint (GO:0072395)2.92276753
54signal transduction involved in DNA damage checkpoint (GO:0072422)2.91770181
55signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91770181
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.91743662
57tRNA processing (GO:0008033)2.91213311
58electron transport chain (GO:0022900)2.91205833
59respiratory electron transport chain (GO:0022904)2.90121664
60peptidyl-histidine modification (GO:0018202)2.90039546
61negative regulation of telomere maintenance (GO:0032205)2.90021822
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89606716
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89519556
64negative regulation of ligase activity (GO:0051352)2.89519556
65regulation of mitotic spindle checkpoint (GO:1903504)2.87759483
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.87759483
67rRNA modification (GO:0000154)2.84547706
68GTP biosynthetic process (GO:0006183)2.83241278
69protein-cofactor linkage (GO:0018065)2.81478851
70GPI anchor metabolic process (GO:0006505)2.81211430
71base-excision repair, AP site formation (GO:0006285)2.78081303
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.76326916
73isotype switching (GO:0045190)2.76326916
74somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.76326916
75purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.73622592
76GPI anchor biosynthetic process (GO:0006506)2.73200716
77behavioral response to nicotine (GO:0035095)2.70104461
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.69026725
79maturation of 5.8S rRNA (GO:0000460)2.66079199
80S-adenosylmethionine metabolic process (GO:0046500)2.65968139
81branched-chain amino acid catabolic process (GO:0009083)2.64630552
82ubiquinone biosynthetic process (GO:0006744)2.63738301
83positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.62263617
84deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.61850068
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.61828449
86positive regulation of defense response to virus by host (GO:0002230)2.60277667
87purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.58985268
88aldehyde catabolic process (GO:0046185)2.56338362
89DNA catabolic process, exonucleolytic (GO:0000738)2.54970273
90positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.54128189
91L-methionine biosynthetic process (GO:0071265)2.53215707
92amino acid salvage (GO:0043102)2.53215707
93L-methionine salvage (GO:0071267)2.53215707
94positive regulation of ligase activity (GO:0051351)2.52746191
95ATP biosynthetic process (GO:0006754)2.51325476
96tRNA modification (GO:0006400)2.50505027
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.49991252
98anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49888830
99tRNA metabolic process (GO:0006399)2.49691234
100translation (GO:0006412)2.49153824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.22980526
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.20087016
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.66093408
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.17819295
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.06922588
6ZNF274_21170338_ChIP-Seq_K562_Hela3.01364142
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.01162354
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.99566698
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95185342
10VDR_23849224_ChIP-Seq_CD4+_Human2.88539100
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.67354291
12VDR_22108803_ChIP-Seq_LS180_Human2.57777959
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41318810
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.40708233
15ELK1_19687146_ChIP-ChIP_HELA_Human2.37061611
16FOXP3_21729870_ChIP-Seq_TREG_Human2.35212558
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.29271878
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27012545
19SRF_21415370_ChIP-Seq_HL-1_Mouse2.20513538
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16561124
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.02974124
22IGF1R_20145208_ChIP-Seq_DFB_Human2.01358013
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.91993743
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90401743
25MYC_18940864_ChIP-ChIP_HL60_Human1.87453494
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.84902251
27IRF8_22096565_ChIP-ChIP_GC-B_Human1.83483624
28BP1_19119308_ChIP-ChIP_Hs578T_Human1.78479035
29EWS_26573619_Chip-Seq_HEK293_Human1.75296025
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.71144977
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67678693
32MYC_18555785_ChIP-Seq_MESCs_Mouse1.59517444
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.55709830
34CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55083470
35TP53_22573176_ChIP-Seq_HFKS_Human1.54164601
36IRF1_19129219_ChIP-ChIP_H3396_Human1.53407876
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.51131459
38IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.47967328
39FUS_26573619_Chip-Seq_HEK293_Human1.45736127
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45138134
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.44449703
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42701733
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38406343
44GABP_19822575_ChIP-Seq_HepG2_Human1.37617233
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.36252202
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36035541
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35591308
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34422648
49GATA3_26560356_Chip-Seq_TH2_Human1.29570936
50TTF2_22483619_ChIP-Seq_HELA_Human1.28990801
51TAF15_26573619_Chip-Seq_HEK293_Human1.27450313
52FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.26459472
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25883309
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.25883309
55AR_20517297_ChIP-Seq_VCAP_Human1.25668527
56PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24061714
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23177454
58DCP1A_22483619_ChIP-Seq_HELA_Human1.22196841
59GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21987487
60FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21830880
61P300_19829295_ChIP-Seq_ESCs_Human1.21082349
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20306037
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13626387
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.12605245
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11845549
66STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11800120
67NANOG_19829295_ChIP-Seq_ESCs_Human1.11714804
68SOX2_19829295_ChIP-Seq_ESCs_Human1.11714804
69CIITA_25753668_ChIP-Seq_RAJI_Human1.11570693
70MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11203377
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.11064023
72POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10164863
73POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07518860
74SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.07157194
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06566758
76CBP_20019798_ChIP-Seq_JUKART_Human1.06566758
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06543034
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06289780
79NCOR_22424771_ChIP-Seq_293T_Human1.05769928
80AUTS2_25519132_ChIP-Seq_293T-REX_Human1.02571093
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.02362978
82MYB_26560356_Chip-Seq_TH2_Human1.01811774
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01121500
84FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00479911
85NANOG_20526341_ChIP-Seq_ESCs_Human0.99875883
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99497904
87CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98807575
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.97976914
89EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96445521
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96318876
91PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.96112200
92FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95614604
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.95462298
94GATA3_21878914_ChIP-Seq_MCF-7_Human0.95359381
95FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94461900
96LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94438672
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94317376
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.93278380
99TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91954477
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.90394825

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.36377373
2MP0008877_abnormal_DNA_methylation3.14485115
3MP0002102_abnormal_ear_morphology2.82778214
4MP0006072_abnormal_retinal_apoptosis2.72139098
5MP0004147_increased_porphyrin_level2.46611798
6MP0001835_abnormal_antigen_presentation2.42076023
7MP0002138_abnormal_hepatobiliary_system2.41661564
8MP0008058_abnormal_DNA_repair2.40330959
9MP0003195_calcinosis2.15860738
10MP0005075_abnormal_melanosome_morpholog2.06848317
11MP0006292_abnormal_olfactory_placode2.02641348
12MP0003787_abnormal_imprinting1.99032522
13MP0009785_altered_susceptibility_to1.89650624
14MP0008872_abnormal_physiological_respon1.87408720
15MP0005645_abnormal_hypothalamus_physiol1.84590884
16MP0003786_premature_aging1.83343654
17MP0008875_abnormal_xenobiotic_pharmacok1.83309989
18MP0005084_abnormal_gallbladder_morpholo1.80266302
19MP0000372_irregular_coat_pigmentation1.78381308
20MP0003011_delayed_dark_adaptation1.76681002
21MP0002736_abnormal_nociception_after1.70620501
22MP0002837_dystrophic_cardiac_calcinosis1.70358737
23MP0003806_abnormal_nucleotide_metabolis1.66203286
24MP0005253_abnormal_eye_physiology1.62506303
25MP0002638_abnormal_pupillary_reflex1.60156282
26MP0001968_abnormal_touch/_nociception1.57330882
27MP0006036_abnormal_mitochondrial_physio1.51209698
28MP0005551_abnormal_eye_electrophysiolog1.48463292
29MP0008995_early_reproductive_senescence1.47314421
30MP0001986_abnormal_taste_sensitivity1.46211884
31MP0001800_abnormal_humoral_immune1.44261736
32MP0002876_abnormal_thyroid_physiology1.40031057
33MP0003724_increased_susceptibility_to1.37729030
34MP0005000_abnormal_immune_tolerance1.36191404
35MP0002166_altered_tumor_susceptibility1.35327230
36MP0002163_abnormal_gland_morphology1.34583535
37MP0003646_muscle_fatigue1.33718986
38MP0003763_abnormal_thymus_physiology1.32872385
39MP0002148_abnormal_hypersensitivity_rea1.32654122
40MP0005646_abnormal_pituitary_gland1.31646109
41MP0000685_abnormal_immune_system1.29710665
42MP0004142_abnormal_muscle_tone1.28981867
43MP0002006_tumorigenesis1.26970239
44MP0009333_abnormal_splenocyte_physiolog1.24425852
45MP0001529_abnormal_vocalization1.22888311
46MP0001764_abnormal_homeostasis1.22223199
47MP0003866_abnormal_defecation1.21080692
48MP0001873_stomach_inflammation1.20788088
49MP0002277_abnormal_respiratory_mucosa1.20704353
50MP0004145_abnormal_muscle_electrophysio1.20464244
51MP0005377_hearing/vestibular/ear_phenot1.20084223
52MP0003878_abnormal_ear_physiology1.20084223
53MP0002723_abnormal_immune_serum1.18035687
54MP0003880_abnormal_central_pattern1.17790938
55MP0001905_abnormal_dopamine_level1.17008124
56MP0005389_reproductive_system_phenotype1.15355293
57MP0003718_maternal_effect1.13582852
58MP0008789_abnormal_olfactory_epithelium1.12597040
59MP0001790_abnormal_immune_system1.12458865
60MP0005387_immune_system_phenotype1.12458865
61MP0002420_abnormal_adaptive_immunity1.12265498
62MP0001819_abnormal_immune_cell1.11013992
63MP0010094_abnormal_chromosome_stability1.10329295
64MP0001984_abnormal_olfaction1.09545715
65MP0002938_white_spotting1.09466916
66MP0003693_abnormal_embryo_hatching1.09123346
67MP0001919_abnormal_reproductive_system1.09094484
68MP0004043_abnormal_pH_regulation1.08941699
69MP0006276_abnormal_autonomic_nervous1.08812610
70MP0009764_decreased_sensitivity_to1.06741371
71MP0003186_abnormal_redox_activity1.05770183
72MP0005360_urolithiasis1.05198268
73MP0004885_abnormal_endolymph1.04117951
74MP0001501_abnormal_sleep_pattern1.04100761
75MP0005379_endocrine/exocrine_gland_phen1.02649943
76MP0005332_abnormal_amino_acid1.02051839
77MP0001188_hyperpigmentation1.01591710
78MP0002452_abnormal_antigen_presenting1.01304781
79MP0000689_abnormal_spleen_morphology0.98110642
80MP0006035_abnormal_mitochondrial_morpho0.97956018
81MP0010155_abnormal_intestine_physiology0.94416682
82MP0005636_abnormal_mineral_homeostasis0.93996642
83MP0002254_reproductive_system_inflammat0.92328459
84MP0008007_abnormal_cellular_replicative0.91402296
85MP0003567_abnormal_fetal_cardiomyocyte0.89844536
86MP0002398_abnormal_bone_marrow0.87414504
87MP0002751_abnormal_autonomic_nervous0.87381782
88MP0001845_abnormal_inflammatory_respons0.85169058
89MP0000716_abnormal_immune_system0.85037060
90MP0005025_abnormal_response_to0.84616941
91MP0002160_abnormal_reproductive_system0.82458864
92MP0000516_abnormal_urinary_system0.80938116
93MP0005367_renal/urinary_system_phenotyp0.80938116
94MP0002272_abnormal_nervous_system0.80562223
95MP0001485_abnormal_pinna_reflex0.78941722
96MP0005085_abnormal_gallbladder_physiolo0.78526319
97MP0001119_abnormal_female_reproductive0.78434354
98MP0002234_abnormal_pharynx_morphology0.78317469
99MP0002722_abnormal_immune_system0.75987278
100MP0000703_abnormal_thymus_morphology0.75474289

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.79806552
2Mitochondrial inheritance (HP:0001427)3.63527856
3Abnormal mitochondria in muscle tissue (HP:0008316)3.43673519
4Increased CSF lactate (HP:0002490)3.41947971
5Acute encephalopathy (HP:0006846)3.39647823
63-Methylglutaconic aciduria (HP:0003535)3.36262052
7Hepatocellular necrosis (HP:0001404)3.34521887
8IgG deficiency (HP:0004315)3.33495187
9Pancreatic cysts (HP:0001737)3.29179555
10Methylmalonic acidemia (HP:0002912)3.29043464
11Progressive macrocephaly (HP:0004481)3.28388720
12Hepatic necrosis (HP:0002605)3.13777338
13Increased hepatocellular lipid droplets (HP:0006565)3.04026374
14Methylmalonic aciduria (HP:0012120)2.93051984
15Severe combined immunodeficiency (HP:0004430)2.89918222
16Elevated erythrocyte sedimentation rate (HP:0003565)2.89020394
17Lipid accumulation in hepatocytes (HP:0006561)2.82736052
18Congenital stationary night blindness (HP:0007642)2.76357436
19Abolished electroretinogram (ERG) (HP:0000550)2.74040019
20Pancreatic fibrosis (HP:0100732)2.66927784
21True hermaphroditism (HP:0010459)2.66262926
22Stomatitis (HP:0010280)2.64639036
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61844612
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61844612
25Increased serum lactate (HP:0002151)2.61799375
26Molar tooth sign on MRI (HP:0002419)2.61286954
27Abnormality of midbrain morphology (HP:0002418)2.61286954
28Cerebral edema (HP:0002181)2.58062838
29Aplastic anemia (HP:0001915)2.56979354
30Lactic acidosis (HP:0003128)2.50765602
31Increased intramyocellular lipid droplets (HP:0012240)2.48019488
32Thyroiditis (HP:0100646)2.47737098
33Renal Fanconi syndrome (HP:0001994)2.44183468
34Hypoproteinemia (HP:0003075)2.41598493
35Hyperglycinemia (HP:0002154)2.38489295
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.37932032
37Decreased electroretinogram (ERG) amplitude (HP:0000654)2.35977999
38Abnormality of alanine metabolism (HP:0010916)2.34761420
39Hyperalaninemia (HP:0003348)2.34761420
40Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.34761420
41Abnormality of vitamin B metabolism (HP:0004340)2.32043332
42Hypothermia (HP:0002045)2.31549802
43Optic disc pallor (HP:0000543)2.29225876
44Nephronophthisis (HP:0000090)2.28748160
45Abnormality of the vitamin B12 metabolism (HP:0004341)2.26540690
46Aplasia/hypoplasia of the uterus (HP:0008684)2.26438588
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.25074863
48Exertional dyspnea (HP:0002875)2.24460598
49Attenuation of retinal blood vessels (HP:0007843)2.23017306
50Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22800112
51Combined immunodeficiency (HP:0005387)2.22242405
52Abnormality of serum amino acid levels (HP:0003112)2.21296235
53Medial flaring of the eyebrow (HP:0010747)2.21170699
54Type I transferrin isoform profile (HP:0003642)2.21081075
55Type 2 muscle fiber atrophy (HP:0003554)2.19340047
56Lethargy (HP:0001254)2.18568229
57Pendular nystagmus (HP:0012043)2.16272419
58Colon cancer (HP:0003003)2.15604016
59Abnormal rod and cone electroretinograms (HP:0008323)2.13902734
60Abnormality of the labia minora (HP:0012880)2.10900636
61Dicarboxylic aciduria (HP:0003215)2.10581552
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10581552
63Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08925855
64Abnormality of serine family amino acid metabolism (HP:0010894)2.08368050
65Abnormality of glycine metabolism (HP:0010895)2.08368050
66Congenital, generalized hypertrichosis (HP:0004540)2.07758517
67Abnormality of the renal cortex (HP:0011035)2.07215402
68Renal cortical cysts (HP:0000803)2.04672832
69Abnormality of eosinophils (HP:0001879)2.03549475
70Increased muscle lipid content (HP:0009058)2.02421333
71Abnormality of T cells (HP:0002843)2.01738550
72Abnormal protein glycosylation (HP:0012346)2.01223766
73Abnormal glycosylation (HP:0012345)2.01223766
74Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01223766
75Abnormal protein N-linked glycosylation (HP:0012347)2.01223766
76T lymphocytopenia (HP:0005403)2.00346125
77Abnormality of B cell number (HP:0010975)2.00076488
78Abnormality of the pons (HP:0007361)1.98074319
79Delayed CNS myelination (HP:0002188)1.97546276
80Respiratory failure (HP:0002878)1.97326462
81Pancytopenia (HP:0001876)1.95594609
82Abnormality of T cell number (HP:0011839)1.94700741
83Panhypogammaglobulinemia (HP:0003139)1.92606567
84Hypoplasia of the pons (HP:0012110)1.92598524
85Abnormal biliary tract physiology (HP:0012439)1.91971172
86Bile duct proliferation (HP:0001408)1.91971172
87Abnormality of the prostate (HP:0008775)1.91189270
88B lymphocytopenia (HP:0010976)1.90628143
89Glycosuria (HP:0003076)1.87406320
90Abnormality of urine glucose concentration (HP:0011016)1.87406320
91Abnormality of the renal medulla (HP:0100957)1.84472778
92Hypomagnesemia (HP:0002917)1.84345782
93Ketosis (HP:0001946)1.83600381
94Decreased central vision (HP:0007663)1.80683649
95Hyperglycinuria (HP:0003108)1.80102488
96Exercise intolerance (HP:0003546)1.79574892
97Ketoacidosis (HP:0001993)1.78119089
98Cerebral palsy (HP:0100021)1.77141085
99Generalized aminoaciduria (HP:0002909)1.76101257
100Sclerocornea (HP:0000647)1.75009521

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.63960062
2TXK3.16520752
3ZAK3.08570980
4NUAK12.75795891
5FRK2.64925908
6TAOK32.57372708
7VRK22.44141743
8BCKDK2.42509990
9TRIM282.17211305
10TLK12.15367967
11ADRBK22.11769339
12WNK32.07140410
13MST42.04578565
14GRK11.95640770
15KDR1.89251763
16STK161.88025164
17EIF2AK31.78892520
18SRPK11.75835636
19CDK191.69634411
20BMPR1B1.61382473
21PASK1.48128726
22VRK11.47757059
23BUB11.46872293
24TIE11.42059122
25TSSK61.40453957
26MAP4K11.38440755
27WNK41.30772404
28MKNK11.26635209
29ACVR1B1.24490164
30PLK31.19167977
31MKNK21.14659571
32OXSR11.13178932
33TEC1.08077567
34PINK11.07927469
35ERBB31.07755597
36FES1.07739238
37IKBKB1.05690943
38DYRK21.03918678
39CSNK1G31.03255016
40ITK1.02827226
41NME11.02352304
42CSNK1G11.01162265
43RPS6KA40.99224381
44BCR0.98127800
45INSRR0.95787628
46TESK20.94921415
47TNIK0.91289291
48GRK60.87315278
49MAP3K40.85205872
50CSNK1G20.83721240
51IKBKE0.83621017
52RPS6KA50.81799110
53PLK40.80028500
54DAPK10.79397828
55KIT0.77670631
56FLT30.74920681
57TGFBR10.71476913
58NEK10.70117000
59LIMK10.69398176
60MAPK130.68615360
61CSNK1A1L0.68293815
62MAP3K120.67956133
63NLK0.67849090
64PLK20.67496893
65SYK0.66893801
66MUSK0.65512954
67PRKCQ0.64524801
68LCK0.63719680
69PHKG20.62280886
70PHKG10.62280886
71ATR0.61987702
72LYN0.58787226
73MAP2K60.58225109
74PLK10.55565865
75PRKCE0.52648238
76EIF2AK20.52430168
77MAP2K70.51344951
78ADRBK10.50797188
79CDC70.50524351
80CSF1R0.49093400
81STK390.47917233
82CSNK2A10.47158099
83PRKCG0.42897596
84BMPR20.42823189
85MAPKAPK30.42524192
86CSNK1A10.42327816
87PIK3CA0.39900269
88IGF1R0.38827688
89DAPK20.38381575
90MAP2K20.38137146
91CSNK2A20.37774530
92PIM10.37191771
93BTK0.37130603
94MYLK0.36139508
95SIK30.32961215
96EIF2AK10.32604388
97PRKCA0.32226249
98TNK20.30808477
99PAK30.30450995
100AURKB0.30299370

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.93833640
2Oxidative phosphorylation_Homo sapiens_hsa001902.94480295
3Protein export_Homo sapiens_hsa030602.80750468
4Asthma_Homo sapiens_hsa053102.53501869
5Ribosome_Homo sapiens_hsa030102.52310236
6Parkinsons disease_Homo sapiens_hsa050122.42609369
7Allograft rejection_Homo sapiens_hsa053302.38747699
8Primary immunodeficiency_Homo sapiens_hsa053402.37825370
9RNA polymerase_Homo sapiens_hsa030202.35525932
10Autoimmune thyroid disease_Homo sapiens_hsa053202.27996152
11Type I diabetes mellitus_Homo sapiens_hsa049402.19117051
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.16093296
13Graft-versus-host disease_Homo sapiens_hsa053322.13309050
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00219827
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.73331485
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.72820775
17Propanoate metabolism_Homo sapiens_hsa006401.72694529
18RNA degradation_Homo sapiens_hsa030181.71665096
19Homologous recombination_Homo sapiens_hsa034401.60516106
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60397243
21Antigen processing and presentation_Homo sapiens_hsa046121.54844712
22Phototransduction_Homo sapiens_hsa047441.45480556
23Huntingtons disease_Homo sapiens_hsa050161.45078445
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44868491
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41837805
26One carbon pool by folate_Homo sapiens_hsa006701.39906318
27Alzheimers disease_Homo sapiens_hsa050101.38915794
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.34975684
29Basal transcription factors_Homo sapiens_hsa030221.34853259
30Mismatch repair_Homo sapiens_hsa034301.34825053
31Sulfur metabolism_Homo sapiens_hsa009201.30736868
32Linoleic acid metabolism_Homo sapiens_hsa005911.28103308
33Butanoate metabolism_Homo sapiens_hsa006501.28085416
34Non-homologous end-joining_Homo sapiens_hsa034501.24119727
35Pyrimidine metabolism_Homo sapiens_hsa002401.22545494
36Fatty acid elongation_Homo sapiens_hsa000621.20822220
37Fanconi anemia pathway_Homo sapiens_hsa034601.20126683
38Spliceosome_Homo sapiens_hsa030401.17511025
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.16084554
40RNA transport_Homo sapiens_hsa030131.12690548
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.11871249
42Nitrogen metabolism_Homo sapiens_hsa009101.11543419
43DNA replication_Homo sapiens_hsa030301.11533682
44Caffeine metabolism_Homo sapiens_hsa002321.10718127
45Peroxisome_Homo sapiens_hsa041461.09566535
46Rheumatoid arthritis_Homo sapiens_hsa053231.08838663
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.07431367
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.07256369
49Purine metabolism_Homo sapiens_hsa002301.05177703
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.05100671
51Tryptophan metabolism_Homo sapiens_hsa003800.98859317
52Selenocompound metabolism_Homo sapiens_hsa004500.96202033
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.94097272
54Base excision repair_Homo sapiens_hsa034100.92898204
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92840860
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91590809
57Regulation of autophagy_Homo sapiens_hsa041400.90297599
58Hematopoietic cell lineage_Homo sapiens_hsa046400.89762784
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89574291
60Nucleotide excision repair_Homo sapiens_hsa034200.89406625
61Cardiac muscle contraction_Homo sapiens_hsa042600.84141307
62Collecting duct acid secretion_Homo sapiens_hsa049660.78832734
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77948146
64Arachidonic acid metabolism_Homo sapiens_hsa005900.77889393
65SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76470233
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73352362
67Viral myocarditis_Homo sapiens_hsa054160.71104064
68Chemical carcinogenesis_Homo sapiens_hsa052040.69791781
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69064578
70Ether lipid metabolism_Homo sapiens_hsa005650.68290687
71Metabolic pathways_Homo sapiens_hsa011000.67487867
72Retinol metabolism_Homo sapiens_hsa008300.64599713
73Systemic lupus erythematosus_Homo sapiens_hsa053220.62714256
74Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61627318
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61021267
76Glutathione metabolism_Homo sapiens_hsa004800.60883954
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60713884
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60553268
79Sulfur relay system_Homo sapiens_hsa041220.56977988
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.56584013
81Fat digestion and absorption_Homo sapiens_hsa049750.55898081
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55818719
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54013229
84Drug metabolism - other enzymes_Homo sapiens_hsa009830.53774353
85Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49463515
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47218158
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46578427
88beta-Alanine metabolism_Homo sapiens_hsa004100.42165407
89Pyruvate metabolism_Homo sapiens_hsa006200.42106915
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41368058
91Herpes simplex infection_Homo sapiens_hsa051680.40965928
92Steroid hormone biosynthesis_Homo sapiens_hsa001400.40909560
93Olfactory transduction_Homo sapiens_hsa047400.39875611
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34357329
95Nicotine addiction_Homo sapiens_hsa050330.33686947
96Taste transduction_Homo sapiens_hsa047420.33635120
97Staphylococcus aureus infection_Homo sapiens_hsa051500.32210595
98Steroid biosynthesis_Homo sapiens_hsa001000.30450851
99Epstein-Barr virus infection_Homo sapiens_hsa051690.29209154
100Vitamin digestion and absorption_Homo sapiens_hsa049770.29100989

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