ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.34848221
2	behavioral response to nicotine (GO:0035095)	5.19619857
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.94420087
4	ATP synthesis coupled proton transport (GO:0015986)	4.94420087
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.75733441
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.25973906
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.14146066
8	protein complex biogenesis (GO:0070271)	4.10267202
9	respiratory chain complex IV assembly (GO:0008535)	4.06499558
10	chaperone-mediated protein transport (GO:0072321)	4.05077397
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.03880406
12	protein neddylation (GO:0045116)	3.94617048
13	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.90004703
14	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.90004703
15	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.83285071
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.82455805
17	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.81637630
18	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.81632464
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.77082404
20	NADH dehydrogenase complex assembly (GO:0010257)	3.77082404
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.77082404
22	cytochrome complex assembly (GO:0017004)	3.73072132
23	preassembly of GPI anchor in ER membrane (GO:0016254)	3.66917490
24	maturation of SSU-rRNA (GO:0030490)	3.64193354
25	electron transport chain (GO:0022900)	3.59068790
26	ribosomal small subunit assembly (GO:0000028)	3.57123295
27	respiratory electron transport chain (GO:0022904)	3.56231602
28	response to pheromone (GO:0019236)	3.56062884
29	ribosomal large subunit biogenesis (GO:0042273)	3.46300210
30	proteasome assembly (GO:0043248)	3.41429442
31	rRNA modification (GO:0000154)	3.37169941
32	kynurenine metabolic process (GO:0070189)	3.27526259
33	cytidine deamination (GO:0009972)	3.25185450
34	cytidine metabolic process (GO:0046087)	3.25185450
35	cytidine catabolic process (GO:0006216)	3.25185450
36	positive regulation of protein homodimerization activity (GO:0090073)	3.24575512
37	synaptic transmission, cholinergic (GO:0007271)	3.23493344
38	viral transcription (GO:0019083)	3.11481904
39	tryptophan catabolic process (GO:0006569)	3.09168894
40	indole-containing compound catabolic process (GO:0042436)	3.09168894
41	indolalkylamine catabolic process (GO:0046218)	3.09168894
42	fucose catabolic process (GO:0019317)	3.08808265
43	L-fucose metabolic process (GO:0042354)	3.08808265
44	L-fucose catabolic process (GO:0042355)	3.08808265
45	tRNA processing (GO:0008033)	3.05883568
46	platelet dense granule organization (GO:0060155)	3.05557215
47	translational termination (GO:0006415)	3.05103482
48	GMP metabolic process (GO:0046037)	3.04383852
49	mannosylation (GO:0097502)	3.03883139
50	termination of RNA polymerase III transcription (GO:0006386)	3.03638190
51	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.03638190
52	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.03261952
53	GPI anchor metabolic process (GO:0006505)	3.02927599
54	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.99684547
55	indolalkylamine metabolic process (GO:0006586)	2.99603431
56	cotranslational protein targeting to membrane (GO:0006613)	2.98817525
57	ATP biosynthetic process (GO:0006754)	2.98604732
58	protein targeting to ER (GO:0045047)	2.98113563
59	aldehyde catabolic process (GO:0046185)	2.97326777
60	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.96831964
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94950540
62	GPI anchor biosynthetic process (GO:0006506)	2.94866564
63	positive regulation of prostaglandin secretion (GO:0032308)	2.92668290
64	hydrogen ion transmembrane transport (GO:1902600)	2.91939046
65	pseudouridine synthesis (GO:0001522)	2.87940786
66	translational elongation (GO:0006414)	2.86570678
67	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.86427691
68	protein localization to endoplasmic reticulum (GO:0070972)	2.85109695
69	proton transport (GO:0015992)	2.84450479
70	GTP biosynthetic process (GO:0006183)	2.83378933
71	peptidyl-histidine modification (GO:0018202)	2.82247235
72	hydrogen transport (GO:0006818)	2.79825957
73	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.79784676
74	translation (GO:0006412)	2.78110945
75	negative regulation of heart rate (GO:0010459)	2.74150790
76	tryptophan metabolic process (GO:0006568)	2.72376056
77	piRNA metabolic process (GO:0034587)	2.71628452
78	protein-cofactor linkage (GO:0018065)	2.70212248
79	rRNA methylation (GO:0031167)	2.70093130
80	negative regulation of telomere maintenance (GO:0032205)	2.67605337
81	regulation of cellular amino acid metabolic process (GO:0006521)	2.66770982
82	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.66664589
83	cellular component biogenesis (GO:0044085)	2.64187820
84	ncRNA catabolic process (GO:0034661)	2.62588976
85	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.60216458
86	inositol phosphate dephosphorylation (GO:0046855)	2.59123913
87	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.59123913
88	positive regulation of defense response to virus by host (GO:0002230)	2.57686313
89	S-adenosylmethionine metabolic process (GO:0046500)	2.55511297
90	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.55140283
91	protein deneddylation (GO:0000338)	2.54651085
92	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.54233208
93	intracellular protein transmembrane import (GO:0044743)	2.53662499
94	maturation of 5.8S rRNA (GO:0000460)	2.52681985
95	DNA double-strand break processing (GO:0000729)	2.52009097
96	tRNA metabolic process (GO:0006399)	2.51182592
97	rRNA catabolic process (GO:0016075)	2.51014474
98	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.49817842
99	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.49817842
100	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.49817842

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.98999798
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.85070045
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.53511180
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.45536093
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.34167814
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.15435874
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.01632297
8	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.96989006
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.86478850
10	VDR_22108803_ChIP-Seq_LS180_Human	2.76556707
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.56554404
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.49908787
13	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42270639
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.41951973
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37867012
16	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.35877257
17	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.18633327
18	FOXP3_21729870_ChIP-Seq_TREG_Human	2.11837976
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.10897483
20	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.94294798
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94288049
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.92895470
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.83524484
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.81230112
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78338180
26	EWS_26573619_Chip-Seq_HEK293_Human	1.73300618
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.65426735
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.61713797
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60527513
30	FUS_26573619_Chip-Seq_HEK293_Human	1.60297954
31	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57423406
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.55066375
33	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.48067440
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47791960
35	IRF1_19129219_ChIP-ChIP_H3396_Human	1.47656142
36	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44830133
37	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.44621049
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.43399060
39	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.43399060
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.37699860
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36939481
42	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.36756258
43	AR_20517297_ChIP-Seq_VCAP_Human	1.35621417
44	P300_19829295_ChIP-Seq_ESCs_Human	1.34806499
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32321044
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32321044
47	EZH2_22144423_ChIP-Seq_EOC_Human	1.29543296
48	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27446909
49	GBX2_23144817_ChIP-Seq_PC3_Human	1.27386780
50	TAF15_26573619_Chip-Seq_HEK293_Human	1.25089352
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.22099797
52	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.20446399
53	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.20401960
54	GATA3_26560356_Chip-Seq_TH2_Human	1.20254977
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.19811420
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.19742126
57	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.18340228
58	CBP_20019798_ChIP-Seq_JUKART_Human	1.18340228
59	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.17694623
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.17483167
61	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.17397640
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16478620
63	NCOR_22424771_ChIP-Seq_293T_Human	1.15297581
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.14470832
65	TTF2_22483619_ChIP-Seq_HELA_Human	1.14295147
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13892906
67	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.12822297
68	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.12609486
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09676461
70	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.09271974
71	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08538155
72	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.06269257
73	ERG_20517297_ChIP-Seq_VCAP_Human	1.06194917
74	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06004904
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.05900763
76	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04522033
77	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.01661312
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.00908302
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.00758151
80	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.00467782
81	NANOG_20526341_ChIP-Seq_ESCs_Human	1.00114285
82	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.98364473
83	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98355229
84	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.97187840
85	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96480315
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.96336809
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.95913970
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95676388
89	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95458045
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.95164396
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.94223409
92	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.94156934
93	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.94086665
94	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.93984922
95	GABP_19822575_ChIP-Seq_HepG2_Human	0.93815631
96	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.91733078
97	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.90392568
98	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.89473332
99	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.89247203
100	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.87301095

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.30778909
2	MP0005646_abnormal_pituitary_gland	2.88437930
3	MP0008877_abnormal_DNA_methylation	2.69286636
4	MP0004147_increased_porphyrin_level	2.54782426
5	MP0008875_abnormal_xenobiotic_pharmacok	2.50178960
6	MP0002837_dystrophic_cardiac_calcinosis	2.49554455
7	MP0005671_abnormal_response_to	2.46752047
8	MP0006072_abnormal_retinal_apoptosis	2.39648461
9	MP0002102_abnormal_ear_morphology	2.31759444
10	MP0004885_abnormal_endolymph	2.17506271
11	MP0003787_abnormal_imprinting	2.07514298
12	MP0003195_calcinosis	2.07365946
13	MP0008872_abnormal_physiological_respon	2.06655187
14	MP0000372_irregular_coat_pigmentation	2.01636798
15	MP0001835_abnormal_antigen_presentation	2.01568857
16	MP0005551_abnormal_eye_electrophysiolog	1.81305879
17	MP0001968_abnormal_touch/_nociception	1.80964326
18	MP0002736_abnormal_nociception_after	1.79493314
19	MP0009379_abnormal_foot_pigmentation	1.78468395
20	MP0005645_abnormal_hypothalamus_physiol	1.75894287
21	MP0004142_abnormal_muscle_tone	1.69018791
22	MP0003806_abnormal_nucleotide_metabolis	1.66395685
23	MP0005253_abnormal_eye_physiology	1.61775575
24	MP0005389_reproductive_system_phenotype	1.55183193
25	MP0001501_abnormal_sleep_pattern	1.50614913
26	MP0003718_maternal_effect	1.50543568
27	MP0001919_abnormal_reproductive_system	1.49302284
28	MP0005075_abnormal_melanosome_morpholog	1.43943318
29	MP0004145_abnormal_muscle_electrophysio	1.42800483
30	MP0002876_abnormal_thyroid_physiology	1.42496336
31	MP0001764_abnormal_homeostasis	1.42061804
32	MP0003646_muscle_fatigue	1.34931941
33	MP0005360_urolithiasis	1.33086646
34	MP0008058_abnormal_DNA_repair	1.32630036
35	MP0005084_abnormal_gallbladder_morpholo	1.31921140
36	MP0002938_white_spotting	1.31255345
37	MP0006036_abnormal_mitochondrial_physio	1.28774008
38	MP0002272_abnormal_nervous_system	1.28007187
39	MP0001485_abnormal_pinna_reflex	1.26601326
40	MP0001986_abnormal_taste_sensitivity	1.26150724
41	MP0000631_abnormal_neuroendocrine_gland	1.25732982
42	MP0002138_abnormal_hepatobiliary_system	1.22480329
43	MP0001800_abnormal_humoral_immune	1.21233417
44	MP0009785_altered_susceptibility_to	1.20129580
45	MP0002166_altered_tumor_susceptibility	1.20024232
46	MP0001905_abnormal_dopamine_level	1.18123844
47	MP0002160_abnormal_reproductive_system	1.16400250
48	MP0002163_abnormal_gland_morphology	1.15992289
49	MP0009745_abnormal_behavioral_response	1.15846279
50	MP0002006_tumorigenesis	1.15420606
51	MP0003011_delayed_dark_adaptation	1.13887879
52	MP0002148_abnormal_hypersensitivity_rea	1.13082183
53	MP0008789_abnormal_olfactory_epithelium	1.12991539
54	MP0000685_abnormal_immune_system	1.11820825
55	MP0001529_abnormal_vocalization	1.11530491
56	MP0002638_abnormal_pupillary_reflex	1.07946072
57	MP0005379_endocrine/exocrine_gland_phen	1.07923060
58	MP0006276_abnormal_autonomic_nervous	1.07300444
59	MP0002234_abnormal_pharynx_morphology	1.05178232
60	MP0005636_abnormal_mineral_homeostasis	1.04797892
61	MP0003186_abnormal_redox_activity	1.03603114
62	MP0001486_abnormal_startle_reflex	1.02362596
63	MP0003786_premature_aging	1.01374457
64	MP0003252_abnormal_bile_duct	1.00728108
65	MP0005332_abnormal_amino_acid	1.00604923
66	MP0008775_abnormal_heart_ventricle	0.98961416
67	MP0009764_decreased_sensitivity_to	0.98540933
68	MP0003878_abnormal_ear_physiology	0.98517942
69	MP0005377_hearing/vestibular/ear_phenot	0.98517942
70	MP0001984_abnormal_olfaction	0.95050357
71	MP0001970_abnormal_pain_threshold	0.93812716
72	MP0000230_abnormal_systemic_arterial	0.93187825
73	MP0003724_increased_susceptibility_to	0.92997423
74	MP0009046_muscle_twitch	0.92647749
75	MP0001293_anophthalmia	0.92185858
76	MP0003693_abnormal_embryo_hatching	0.92105295
77	MP0005387_immune_system_phenotype	0.92025971
78	MP0001790_abnormal_immune_system	0.92025971
79	MP0005174_abnormal_tail_pigmentation	0.89468608
80	MP0002277_abnormal_respiratory_mucosa	0.86171514
81	MP0002723_abnormal_immune_serum	0.86136088
82	MP0002557_abnormal_social/conspecific_i	0.85419076
83	MP0004742_abnormal_vestibular_system	0.84700802
84	MP0009333_abnormal_splenocyte_physiolog	0.84576184
85	MP0000569_abnormal_digit_pigmentation	0.81903460
86	MP0002735_abnormal_chemical_nociception	0.81352780
87	MP0008995_early_reproductive_senescence	0.81090342
88	MP0003866_abnormal_defecation	0.81074860
89	MP0002693_abnormal_pancreas_physiology	0.80316308
90	MP0002572_abnormal_emotion/affect_behav	0.80224904
91	MP0002095_abnormal_skin_pigmentation	0.79218803
92	MP0005195_abnormal_posterior_eye	0.77739145
93	MP0002210_abnormal_sex_determination	0.76671647
94	MP0002733_abnormal_thermal_nociception	0.75752133
95	MP0010155_abnormal_intestine_physiology	0.74237611
96	MP0002452_abnormal_antigen_presenting	0.74237272
97	MP0001929_abnormal_gametogenesis	0.74012694
98	MP0005085_abnormal_gallbladder_physiolo	0.73832840
99	MP0002928_abnormal_bile_duct	0.73643488
100	MP0001819_abnormal_immune_cell	0.73248366

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.04984480
2	Mitochondrial inheritance (HP:0001427)	3.67948546
3	Progressive macrocephaly (HP:0004481)	3.61580072
4	Increased CSF lactate (HP:0002490)	3.58146988
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.50961438
6	Pancreatic cysts (HP:0001737)	3.47861049
7	Acute encephalopathy (HP:0006846)	3.41286338
8	Abnormality of the renal cortex (HP:0011035)	3.21863408
9	Molar tooth sign on MRI (HP:0002419)	3.18142850
10	Abnormality of midbrain morphology (HP:0002418)	3.18142850
11	Congenital stationary night blindness (HP:0007642)	3.16782049
12	Hepatocellular necrosis (HP:0001404)	3.15999099
13	Hepatic necrosis (HP:0002605)	3.11758310
14	Increased hepatocellular lipid droplets (HP:0006565)	3.11051771
15	Pancreatic fibrosis (HP:0100732)	3.05703137
16	Lipid accumulation in hepatocytes (HP:0006561)	3.03867439
17	Nephronophthisis (HP:0000090)	2.89798287
18	Congenital, generalized hypertrichosis (HP:0004540)	2.82895599
19	Methylmalonic acidemia (HP:0002912)	2.79293425
20	Abolished electroretinogram (ERG) (HP:0000550)	2.78972433
21	Renal cortical cysts (HP:0000803)	2.76344476
22	True hermaphroditism (HP:0010459)	2.74909502
23	3-Methylglutaconic aciduria (HP:0003535)	2.74308024
24	Type II lissencephaly (HP:0007260)	2.65963959
25	Abnormality of the renal medulla (HP:0100957)	2.61990717
26	Increased serum lactate (HP:0002151)	2.60485351
27	Cerebral edema (HP:0002181)	2.59103711
28	Hypoproteinemia (HP:0003075)	2.56392224
29	Type I transferrin isoform profile (HP:0003642)	2.55820963
30	IgG deficiency (HP:0004315)	2.52665184
31	Methylmalonic aciduria (HP:0012120)	2.45209799
32	Reduced antithrombin III activity (HP:0001976)	2.44748485
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.44303926
34	Abnormality of the pons (HP:0007361)	2.42540297
35	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.42416502
36	Asplenia (HP:0001746)	2.41750679
37	Optic disc pallor (HP:0000543)	2.41253529
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.38714556
39	Renal Fanconi syndrome (HP:0001994)	2.38528560
40	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.35550664
41	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.35550664
42	Hypoplasia of the pons (HP:0012110)	2.33882929
43	Medial flaring of the eyebrow (HP:0010747)	2.33596713
44	Chronic hepatic failure (HP:0100626)	2.33262578
45	Lactic acidosis (HP:0003128)	2.33182440
46	Stomatitis (HP:0010280)	2.31843752
47	Abnormal biliary tract physiology (HP:0012439)	2.28522206
48	Bile duct proliferation (HP:0001408)	2.28522206
49	Abnormal drinking behavior (HP:0030082)	2.28098686
50	Polydipsia (HP:0001959)	2.28098686
51	Attenuation of retinal blood vessels (HP:0007843)	2.27641492
52	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.27144641
53	Increased intramyocellular lipid droplets (HP:0012240)	2.25632908
54	Optic nerve hypoplasia (HP:0000609)	2.25021047
55	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.18890592
56	Abnormality of cells of the erythroid lineage (HP:0012130)	2.15791805
57	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.15618178
58	Type 2 muscle fiber atrophy (HP:0003554)	2.15221160
59	Thyroiditis (HP:0100646)	2.13533550
60	Decreased central vision (HP:0007663)	2.08542683
61	Exertional dyspnea (HP:0002875)	2.06942567
62	Abnormal number of erythroid precursors (HP:0012131)	2.06587568
63	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.06569387
64	Testicular atrophy (HP:0000029)	2.04662386
65	Absent/shortened dynein arms (HP:0200106)	2.04540801
66	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.04540801
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.03711759
68	Abnormal protein N-linked glycosylation (HP:0012347)	2.03711759
69	Abnormal protein glycosylation (HP:0012346)	2.03711759
70	Abnormal glycosylation (HP:0012345)	2.03711759
71	Abnormality of urine glucose concentration (HP:0011016)	2.02963434
72	Glycosuria (HP:0003076)	2.02963434
73	Lethargy (HP:0001254)	2.02838183
74	Increased corneal curvature (HP:0100692)	2.02252072
75	Keratoconus (HP:0000563)	2.02252072
76	Adrenal hypoplasia (HP:0000835)	2.00178851
77	Hypothermia (HP:0002045)	1.99948241
78	Aplasia/hypoplasia of the uterus (HP:0008684)	1.99905564
79	Constricted visual fields (HP:0001133)	1.99159370
80	Pendular nystagmus (HP:0012043)	1.99153135
81	Tubular atrophy (HP:0000092)	1.98801374
82	Reticulocytopenia (HP:0001896)	1.96595988
83	Absent thumb (HP:0009777)	1.95881855
84	Hypomagnesemia (HP:0002917)	1.95227768
85	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93560393
86	Polyuria (HP:0000103)	1.93380190
87	Supernumerary spleens (HP:0009799)	1.91276022
88	Severe combined immunodeficiency (HP:0004430)	1.90324651
89	Increased muscle lipid content (HP:0009058)	1.90143556
90	Sclerocornea (HP:0000647)	1.89267848
91	Abnormality of the labia minora (HP:0012880)	1.85341507
92	Respiratory failure (HP:0002878)	1.84699391
93	Large for gestational age (HP:0001520)	1.84458672
94	Cystic liver disease (HP:0006706)	1.83890042
95	Abnormality of magnesium homeostasis (HP:0004921)	1.78122736
96	Abnormality of vitamin B metabolism (HP:0004340)	1.77500594
97	Leukodystrophy (HP:0002415)	1.77101340
98	Macrocytic anemia (HP:0001972)	1.75055047
99	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73047775
100	Dicarboxylic aciduria (HP:0003215)	1.73047775

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.98803235
2	FRK	3.46626825
3	TLK1	3.05221480
4	NUAK1	2.92129551
5	TAOK3	2.84560610
6	TXK	2.77280840
7	EIF2AK3	2.62848780
8	ZAK	2.57801619
9	ADRBK2	2.38229271
10	GRK1	2.37454998
11	VRK2	2.32373596
12	TIE1	2.10773674
13	WNK4	2.08134957
14	CDK19	2.03636821
15	BCKDK	1.98706904
16	BMPR1B	1.81571250
17	OXSR1	1.63926479
18	STK39	1.58167344
19	MST4	1.55257632
20	DYRK2	1.45833293
21	WNK3	1.40362036
22	VRK1	1.39562686
23	STK16	1.34265198
24	EIF2AK2	1.26418248
25	TNIK	1.23070216
26	PINK1	1.22686416
27	INSRR	1.22039009
28	MAP3K12	1.21319927
29	WEE1	1.20565851
30	NME1	1.19673379
31	CAMKK2	1.19347204
32	PLK3	1.16248223
33	IKBKB	1.15220802
34	NEK1	1.13824395
35	TEC	1.08110425
36	PHKG2	1.07207942
37	PHKG1	1.07207942
38	BRSK2	1.06991270
39	BMPR2	1.05836127
40	KIT	1.00893768
41	TRIM28	0.99762194
42	MAP4K1	0.95404364
43	BUB1	0.94264305
44	PASK	0.93822204
45	MAP2K6	0.90425368
46	ITK	0.89439436
47	TGFBR1	0.85133487
48	SYK	0.79772537
49	TSSK6	0.79612672
50	MAPK13	0.76314790
51	FES	0.75870333
52	ERBB3	0.74819522
53	MYLK	0.73717301
54	KDR	0.73548351
55	DAPK2	0.73526375
56	IKBKE	0.68706960
57	EIF2AK1	0.68265973
58	FLT3	0.67276370
59	MKNK1	0.66203574
60	TRPM7	0.62074401
61	MKNK2	0.61897134
62	GRK6	0.60031961
63	PRKCQ	0.59751650
64	CSF1R	0.58724689
65	PLK2	0.58683158
66	PRKCG	0.58659706
67	PRKCE	0.57434381
68	ADRBK1	0.55985605
69	LYN	0.55890622
70	AURKB	0.52628194
71	RPS6KA5	0.52410129
72	PKN1	0.51135104
73	CAMK1	0.50224703
74	CSNK1G2	0.50107098
75	PAK3	0.49946709
76	DAPK1	0.49896146
77	SRPK1	0.47276863
78	CSNK1G3	0.46941150
79	ALK	0.46448555
80	ACVR1B	0.43951039
81	CDK8	0.43512884
82	TNK2	0.42837289
83	IGF1R	0.42806770
84	ATR	0.42448175
85	LCK	0.41445161
86	CDC7	0.41059295
87	CSNK2A1	0.40728539
88	ERBB2	0.40126821
89	MUSK	0.39495142
90	TAF1	0.38852521
91	OBSCN	0.38787045
92	BTK	0.38693418
93	PIK3CA	0.37854912
94	PRKACA	0.37612699
95	CSNK2A2	0.36704957
96	PLK4	0.35439354
97	GRK7	0.35309049
98	PRKCA	0.34676099
99	CSNK1G1	0.34550934
100	ATM	0.33488876

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.40692861
2	Asthma_Homo sapiens_hsa05310	3.38204574
3	Proteasome_Homo sapiens_hsa03050	3.25807371
4	Ribosome_Homo sapiens_hsa03010	3.11025192
5	Parkinsons disease_Homo sapiens_hsa05012	2.71325097
6	Protein export_Homo sapiens_hsa03060	2.58473247
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.54806944
8	RNA polymerase_Homo sapiens_hsa03020	2.40634191
9	Allograft rejection_Homo sapiens_hsa05330	2.40236517
10	Caffeine metabolism_Homo sapiens_hsa00232	2.34981696
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.33356223
12	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.27147658
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.21981955
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.92739354
15	Homologous recombination_Homo sapiens_hsa03440	1.90217991
16	Phototransduction_Homo sapiens_hsa04744	1.84558201
17	Huntingtons disease_Homo sapiens_hsa05016	1.76252429
18	Alzheimers disease_Homo sapiens_hsa05010	1.74853610
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.74119333
20	RNA degradation_Homo sapiens_hsa03018	1.66984832
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59480603
22	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.58184600
23	Cardiac muscle contraction_Homo sapiens_hsa04260	1.44308859
24	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.39014203
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.36754759
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.34150332
27	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.32368538
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.29970284
29	One carbon pool by folate_Homo sapiens_hsa00670	1.29122821
30	Primary immunodeficiency_Homo sapiens_hsa05340	1.24853796
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.24487764
32	Propanoate metabolism_Homo sapiens_hsa00640	1.24369304
33	Basal transcription factors_Homo sapiens_hsa03022	1.22085850
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21989183
35	Butanoate metabolism_Homo sapiens_hsa00650	1.17577510
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16252201
37	Purine metabolism_Homo sapiens_hsa00230	1.13286904
38	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.06976422
39	Nitrogen metabolism_Homo sapiens_hsa00910	1.04586950
40	Antigen processing and presentation_Homo sapiens_hsa04612	1.02738086
41	Pyrimidine metabolism_Homo sapiens_hsa00240	1.02348296
42	Rheumatoid arthritis_Homo sapiens_hsa05323	1.02105615
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01592252
44	Nucleotide excision repair_Homo sapiens_hsa03420	1.01045930
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00241635
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.99828733
47	Selenocompound metabolism_Homo sapiens_hsa00450	0.97752106
48	Ether lipid metabolism_Homo sapiens_hsa00565	0.97041340
49	Peroxisome_Homo sapiens_hsa04146	0.95999306
50	Mismatch repair_Homo sapiens_hsa03430	0.87794805
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.86122197
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.85858922
53	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.84677496
54	Nicotine addiction_Homo sapiens_hsa05033	0.81558927
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.79477357
56	Sulfur metabolism_Homo sapiens_hsa00920	0.77259248
57	RNA transport_Homo sapiens_hsa03013	0.75137875
58	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.74487308
59	Spliceosome_Homo sapiens_hsa03040	0.74251039
60	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.73413409
61	Regulation of autophagy_Homo sapiens_hsa04140	0.73298390
62	Olfactory transduction_Homo sapiens_hsa04740	0.71120576
63	Retinol metabolism_Homo sapiens_hsa00830	0.69430877
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.69179183
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66412203
66	Metabolic pathways_Homo sapiens_hsa01100	0.66002376
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65238656
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.64450907
69	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63021406
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.62466979
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.57952568
72	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.57110229
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.55938580
74	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.55765894
75	Non-homologous end-joining_Homo sapiens_hsa03450	0.55751573
76	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54539174
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.54487011
78	Collecting duct acid secretion_Homo sapiens_hsa04966	0.53771233
79	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52340872
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51584395
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.51483166
82	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49728360
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.49407824
84	Glutathione metabolism_Homo sapiens_hsa00480	0.48377323
85	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.48190674
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46723173
87	Viral myocarditis_Homo sapiens_hsa05416	0.45866884
88	Base excision repair_Homo sapiens_hsa03410	0.45237252
89	Fatty acid elongation_Homo sapiens_hsa00062	0.43256695
90	Fatty acid degradation_Homo sapiens_hsa00071	0.41983391
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.41360086
92	Morphine addiction_Homo sapiens_hsa05032	0.41215434
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.40393091
94	Folate biosynthesis_Homo sapiens_hsa00790	0.37728528
95	Mineral absorption_Homo sapiens_hsa04978	0.37526984
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36810966
97	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36668233
98	Taste transduction_Homo sapiens_hsa04742	0.36580260
99	Salivary secretion_Homo sapiens_hsa04970	0.31180723
100	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.28384968

RPL3P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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