RPL3P5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.93869393
2water-soluble vitamin biosynthetic process (GO:0042364)5.12339172
3ATP synthesis coupled proton transport (GO:0015986)4.57202464
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57202464
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.18705891
6ribosomal small subunit assembly (GO:0000028)4.16794922
7establishment of protein localization to mitochondrial membrane (GO:0090151)4.00900015
8chaperone-mediated protein transport (GO:0072321)3.86091994
9proteasome assembly (GO:0043248)3.82745071
10cytidine metabolic process (GO:0046087)3.79971569
11cytidine catabolic process (GO:0006216)3.79971569
12cytidine deamination (GO:0009972)3.79971569
13protein complex biogenesis (GO:0070271)3.75571000
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74879865
15regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.73080067
16maturation of 5.8S rRNA (GO:0000460)3.65925071
17protein neddylation (GO:0045116)3.65094228
18rRNA modification (GO:0000154)3.61286376
19response to pheromone (GO:0019236)3.56162679
20ribosomal large subunit biogenesis (GO:0042273)3.51717485
21cullin deneddylation (GO:0010388)3.49562664
22mitochondrial respiratory chain complex assembly (GO:0033108)3.48410384
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.44093072
24NADH dehydrogenase complex assembly (GO:0010257)3.44093072
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.44093072
26termination of RNA polymerase III transcription (GO:0006386)3.36253943
27transcription elongation from RNA polymerase III promoter (GO:0006385)3.36253943
28electron transport chain (GO:0022900)3.34825985
29nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34634761
30respiratory electron transport chain (GO:0022904)3.33324248
31positive regulation of prostaglandin secretion (GO:0032308)3.31000623
32protein-cofactor linkage (GO:0018065)3.26220540
33pseudouridine synthesis (GO:0001522)3.23299061
34protein deneddylation (GO:0000338)3.23116832
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20562147
36aldehyde catabolic process (GO:0046185)3.19940547
37pyrimidine ribonucleoside catabolic process (GO:0046133)3.17766290
38DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.14395893
39regulation of cellular amino acid metabolic process (GO:0006521)3.12902627
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.09282501
41signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.06948592
42signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.06948592
43signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.06948592
44fucose catabolic process (GO:0019317)3.06678063
45L-fucose metabolic process (GO:0042354)3.06678063
46L-fucose catabolic process (GO:0042355)3.06678063
47signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.02668457
48intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.02668457
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.98629785
50respiratory chain complex IV assembly (GO:0008535)2.95961170
51maturation of SSU-rRNA (GO:0030490)2.94382774
52indolalkylamine catabolic process (GO:0046218)2.92355874
53tryptophan catabolic process (GO:0006569)2.92355874
54indole-containing compound catabolic process (GO:0042436)2.92355874
55signal transduction involved in DNA integrity checkpoint (GO:0072401)2.91367917
56signal transduction involved in DNA damage checkpoint (GO:0072422)2.91367917
57signal transduction involved in cell cycle checkpoint (GO:0072395)2.87964987
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.87885446
59GTP biosynthetic process (GO:0006183)2.87368378
60cytochrome complex assembly (GO:0017004)2.85061533
61piRNA metabolic process (GO:0034587)2.84721304
62vitamin biosynthetic process (GO:0009110)2.83179892
63ubiquinone biosynthetic process (GO:0006744)2.81470110
64viral transcription (GO:0019083)2.78128629
65rRNA methylation (GO:0031167)2.76283448
66RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76268485
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76268485
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.74500444
69tRNA processing (GO:0008033)2.74060696
70negative regulation of ligase activity (GO:0051352)2.74058231
71negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74058231
72tryptophan metabolic process (GO:0006568)2.71744487
73indolalkylamine metabolic process (GO:0006586)2.70968970
74response to interferon-beta (GO:0035456)2.70671407
75translation (GO:0006412)2.69064302
76translational elongation (GO:0006414)2.68902218
77regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.67113851
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.66215959
79translational termination (GO:0006415)2.65977305
80purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65659078
81behavioral response to nicotine (GO:0035095)2.64755808
82protein targeting to ER (GO:0045047)2.63773830
83cotranslational protein targeting to membrane (GO:0006613)2.63421331
84kynurenine metabolic process (GO:0070189)2.62485862
85preassembly of GPI anchor in ER membrane (GO:0016254)2.59561695
86ATP biosynthetic process (GO:0006754)2.58803510
87rRNA catabolic process (GO:0016075)2.58147275
88cellular component biogenesis (GO:0044085)2.58070837
89regulation of prostaglandin secretion (GO:0032306)2.56887989
90intracellular protein transmembrane import (GO:0044743)2.54646952
91regulation of chronic inflammatory response (GO:0002676)2.52656268
92protein localization to endoplasmic reticulum (GO:0070972)2.51759271
93immunoglobulin mediated immune response (GO:0016064)2.50634753
94hydrogen ion transmembrane transport (GO:1902600)2.50119596
95ubiquinone metabolic process (GO:0006743)2.49384968
96DNA catabolic process, exonucleolytic (GO:0000738)2.49106830
97phosphatidylinositol acyl-chain remodeling (GO:0036149)2.48890011
98negative regulation of telomere maintenance (GO:0032205)2.47198769
99hydrogen transport (GO:0006818)2.47046448
100proton transport (GO:0015992)2.47001615

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.55086203
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.12832943
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.95698472
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95548866
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33745126
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.16643912
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97006519
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.91479344
9VDR_22108803_ChIP-Seq_LS180_Human2.83065331
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.81060420
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72408255
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.56179236
13ZNF274_21170338_ChIP-Seq_K562_Hela2.50331174
14VDR_23849224_ChIP-Seq_CD4+_Human2.49652391
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47091755
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.43834824
17IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.27445987
18FOXP3_21729870_ChIP-Seq_TREG_Human2.20678640
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.20466336
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.20008601
21ELK1_19687146_ChIP-ChIP_HELA_Human2.14865071
22IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.03913166
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92714671
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.91104648
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.90891429
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81947294
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.76262707
28IGF1R_20145208_ChIP-Seq_DFB_Human1.76148776
29EWS_26573619_Chip-Seq_HEK293_Human1.69905107
30MYC_18555785_ChIP-Seq_MESCs_Mouse1.64464170
31MYC_18940864_ChIP-ChIP_HL60_Human1.63296785
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.59068274
33CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.58584993
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52615007
35TP53_22573176_ChIP-Seq_HFKS_Human1.49442688
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.48810418
37IRF1_19129219_ChIP-ChIP_H3396_Human1.45093603
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43236385
39AR_20517297_ChIP-Seq_VCAP_Human1.41355931
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.40976048
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.40976048
42EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39894645
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38325228
44GATA3_26560356_Chip-Seq_TH2_Human1.32925739
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.31258521
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28489204
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27669665
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27307594
49PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26794005
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.25428724
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24371955
52GATA3_21878914_ChIP-Seq_MCF-7_Human1.24125680
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20541350
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.16786491
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.16642140
56FUS_26573619_Chip-Seq_HEK293_Human1.16041361
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15300889
58PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14953620
59AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13392261
60SOX2_19829295_ChIP-Seq_ESCs_Human1.13329024
61NANOG_19829295_ChIP-Seq_ESCs_Human1.13329024
62LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12695919
63ER_23166858_ChIP-Seq_MCF-7_Human1.12325451
64TTF2_22483619_ChIP-Seq_HELA_Human1.12256082
65NCOR_22424771_ChIP-Seq_293T_Human1.11134482
66TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10840704
67PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10271066
68TAF2_19829295_ChIP-Seq_ESCs_Human1.09204654
69POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08790835
70MYC_19829295_ChIP-Seq_ESCs_Human1.08151526
71FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08120819
72GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08117005
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07817310
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06848030
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04976859
76NANOG_20526341_ChIP-Seq_ESCs_Human1.04891367
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.03775939
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.03465847
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03430255
80GABP_19822575_ChIP-Seq_HepG2_Human1.02506899
81SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.02005636
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99195738
83FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98833516
84NFE2_27457419_Chip-Seq_LIVER_Mouse0.98257231
85CIITA_25753668_ChIP-Seq_RAJI_Human0.97483879
86ELK1_22589737_ChIP-Seq_MCF10A_Human0.97323035
87FOXH1_21741376_ChIP-Seq_EPCs_Human0.96836419
88TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96294584
89P300_19829295_ChIP-Seq_ESCs_Human0.96252213
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96195126
91CBP_20019798_ChIP-Seq_JUKART_Human0.96195126
92DCP1A_22483619_ChIP-Seq_HELA_Human0.95842753
93ERG_20517297_ChIP-Seq_VCAP_Human0.95344510
94STAT1_20625510_ChIP-Seq_HELA_Human0.95233606
95HOXB7_26014856_ChIP-Seq_BT474_Human0.95163774
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94162747
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92535468
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92353501
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91573226
100E2F1_18555785_ChIP-Seq_MESCs_Mouse0.90860797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.30287505
2MP0005084_abnormal_gallbladder_morpholo2.99927120
3MP0001835_abnormal_antigen_presentation2.74018725
4MP0003806_abnormal_nucleotide_metabolis2.60345786
5MP0008875_abnormal_xenobiotic_pharmacok2.48703652
6MP0005671_abnormal_response_to2.48331919
7MP0008872_abnormal_physiological_respon2.35982691
8MP0008058_abnormal_DNA_repair2.34062258
9MP0008877_abnormal_DNA_methylation2.17176786
10MP0000685_abnormal_immune_system2.15672150
11MP0002102_abnormal_ear_morphology2.11035105
12MP0004147_increased_porphyrin_level2.02245967
13MP0003195_calcinosis1.92547977
14MP0003252_abnormal_bile_duct1.88333864
15MP0006292_abnormal_olfactory_placode1.87742360
16MP0000372_irregular_coat_pigmentation1.85563744
17MP0002876_abnormal_thyroid_physiology1.82340696
18MP0002166_altered_tumor_susceptibility1.80259395
19MP0005645_abnormal_hypothalamus_physiol1.76393536
20MP0001968_abnormal_touch/_nociception1.72581972
21MP0001800_abnormal_humoral_immune1.71391114
22MP0002148_abnormal_hypersensitivity_rea1.69493409
23MP0005646_abnormal_pituitary_gland1.66462488
24MP0005075_abnormal_melanosome_morpholog1.64278920
25MP0009785_altered_susceptibility_to1.63840733
26MP0002006_tumorigenesis1.63463560
27MP0006072_abnormal_retinal_apoptosis1.58962115
28MP0001873_stomach_inflammation1.57023463
29MP0005085_abnormal_gallbladder_physiolo1.56530773
30MP0005167_abnormal_blood-brain_barrier1.56249891
31MP0003786_premature_aging1.55825434
32MP0003718_maternal_effect1.55766909
33MP0001790_abnormal_immune_system1.48545848
34MP0005387_immune_system_phenotype1.48545848
35MP0006036_abnormal_mitochondrial_physio1.47015614
36MP0001986_abnormal_taste_sensitivity1.44528858
37MP0003186_abnormal_redox_activity1.42174447
38MP0002139_abnormal_hepatobiliary_system1.42114683
39MP0005360_urolithiasis1.42099607
40MP0009764_decreased_sensitivity_to1.40759701
41MP0004885_abnormal_endolymph1.39996257
42MP0005551_abnormal_eye_electrophysiolog1.38279555
43MP0001764_abnormal_homeostasis1.36713954
44MP0001905_abnormal_dopamine_level1.36080749
45MP0003866_abnormal_defecation1.34977845
46MP0002736_abnormal_nociception_after1.34870790
47MP0005000_abnormal_immune_tolerance1.33598943
48MP0002723_abnormal_immune_serum1.32695745
49MP0003011_delayed_dark_adaptation1.30595350
50MP0010155_abnormal_intestine_physiology1.30476314
51MP0009379_abnormal_foot_pigmentation1.29438423
52MP0004142_abnormal_muscle_tone1.28920657
53MP0001501_abnormal_sleep_pattern1.27672247
54MP0002452_abnormal_antigen_presenting1.26186307
55MP0003646_muscle_fatigue1.25582771
56MP0002277_abnormal_respiratory_mucosa1.23143908
57MP0003724_increased_susceptibility_to1.21686270
58MP0002928_abnormal_bile_duct1.21158521
59MP0002234_abnormal_pharynx_morphology1.19576219
60MP0005389_reproductive_system_phenotype1.16616076
61MP0009333_abnormal_splenocyte_physiolog1.16093228
62MP0002420_abnormal_adaptive_immunity1.13740916
63MP0008775_abnormal_heart_ventricle1.13503379
64MP0001819_abnormal_immune_cell1.13356257
65MP0005636_abnormal_mineral_homeostasis1.13137089
66MP0005410_abnormal_fertilization1.10888640
67MP0004145_abnormal_muscle_electrophysio1.08274422
68MP0003693_abnormal_embryo_hatching1.06761354
69MP0002160_abnormal_reproductive_system1.03812612
70MP0002837_dystrophic_cardiac_calcinosis1.03504287
71MP0003787_abnormal_imprinting1.02363372
72MP0009697_abnormal_copulation1.00986017
73MP0001845_abnormal_inflammatory_respons0.99686168
74MP0008007_abnormal_cellular_replicative0.99649173
75MP0002272_abnormal_nervous_system0.95207861
76MP0005332_abnormal_amino_acid0.95204306
77MP0003638_abnormal_response/metabolism_0.91088663
78MP0005025_abnormal_response_to0.91034131
79MP0001919_abnormal_reproductive_system0.89802796
80MP0001293_anophthalmia0.89572126
81MP0006035_abnormal_mitochondrial_morpho0.89280579
82MP0000230_abnormal_systemic_arterial0.89121375
83MP0005253_abnormal_eye_physiology0.88473871
84MP0005365_abnormal_bile_salt0.87753726
85MP0009643_abnormal_urine_homeostasis0.86952006
86MP0008469_abnormal_protein_level0.84739475
87MP0006082_CNS_inflammation0.84401558
88MP0001663_abnormal_digestive_system0.84094379
89MP0004019_abnormal_vitamin_homeostasis0.83301648
90MP0000716_abnormal_immune_system0.82825765
91MP0002163_abnormal_gland_morphology0.82031526
92MP0005319_abnormal_enzyme/_coenzyme0.81519714
93MP0000689_abnormal_spleen_morphology0.79513767
94MP0002398_abnormal_bone_marrow0.77706966
95MP0002733_abnormal_thermal_nociception0.77647883
96MP0001765_abnormal_ion_homeostasis0.76932434
97MP0004043_abnormal_pH_regulation0.76580944
98MP0010094_abnormal_chromosome_stability0.75191518
99MP0003436_decreased_susceptibility_to0.74949653
100MP0002638_abnormal_pupillary_reflex0.72892936

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.32216907
2Mitochondrial inheritance (HP:0001427)4.05784257
3Abnormal mitochondria in muscle tissue (HP:0008316)4.00907713
4Increased CSF lactate (HP:0002490)3.95217761
5Progressive macrocephaly (HP:0004481)3.86108598
6Increased hepatocellular lipid droplets (HP:0006565)3.80816788
7Acute encephalopathy (HP:0006846)3.79636329
8Hepatocellular necrosis (HP:0001404)3.64430127
9Lipid accumulation in hepatocytes (HP:0006561)3.63639285
10Hepatic necrosis (HP:0002605)3.40868260
11IgG deficiency (HP:0004315)3.20674932
12Renal Fanconi syndrome (HP:0001994)3.17010024
13Stomatitis (HP:0010280)3.15542358
14Cerebral edema (HP:0002181)3.04142081
15Abolished electroretinogram (ERG) (HP:0000550)3.03695030
16Methylmalonic aciduria (HP:0012120)2.99084769
17Increased serum lactate (HP:0002151)2.98891252
18Pancreatic cysts (HP:0001737)2.96768208
19Congenital stationary night blindness (HP:0007642)2.84567463
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.81329211
21Elevated erythrocyte sedimentation rate (HP:0003565)2.77770841
22Methylmalonic acidemia (HP:0002912)2.75317986
233-Methylglutaconic aciduria (HP:0003535)2.71895831
24Pancreatic fibrosis (HP:0100732)2.66741294
25Colon cancer (HP:0003003)2.65804803
26Hypoproteinemia (HP:0003075)2.65246346
27Lactic acidosis (HP:0003128)2.59519828
28Increased intramyocellular lipid droplets (HP:0012240)2.59366564
29Optic disc pallor (HP:0000543)2.55676094
30Abnormality of the renal cortex (HP:0011035)2.51659390
31Lethargy (HP:0001254)2.51314043
32Abnormal number of erythroid precursors (HP:0012131)2.45846437
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.43055802
34Exertional dyspnea (HP:0002875)2.40091294
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.39893693
36IgM deficiency (HP:0002850)2.38275498
37Respiratory failure (HP:0002878)2.34124606
38Abnormality of the prostate (HP:0008775)2.33709609
39Abnormality of urine glucose concentration (HP:0011016)2.32268810
40Glycosuria (HP:0003076)2.32268810
41Pendular nystagmus (HP:0012043)2.30255074
42Attenuation of retinal blood vessels (HP:0007843)2.29497280
43Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28914549
44Abnormality of cells of the erythroid lineage (HP:0012130)2.26911019
45Abnormal drinking behavior (HP:0030082)2.26783954
46Polydipsia (HP:0001959)2.26783954
47Congenital, generalized hypertrichosis (HP:0004540)2.26172840
48True hermaphroditism (HP:0010459)2.24347608
49Abnormality of midbrain morphology (HP:0002418)2.23759357
50Molar tooth sign on MRI (HP:0002419)2.23759357
51Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20774062
52Bile duct proliferation (HP:0001408)2.19442477
53Abnormal biliary tract physiology (HP:0012439)2.19442477
54Increased muscle lipid content (HP:0009058)2.19436567
55Dicarboxylic aciduria (HP:0003215)2.19132184
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.19132184
57Renal cortical cysts (HP:0000803)2.18619714
58Large for gestational age (HP:0001520)2.17874953
59Abnormal rod and cone electroretinograms (HP:0008323)2.16796141
60Type II lissencephaly (HP:0007260)2.14388277
61Panhypogammaglobulinemia (HP:0003139)2.14105948
62Abnormality of B cell number (HP:0010975)2.11809698
63Aplasia/Hypoplasia of the spleen (HP:0010451)2.10895734
64Abnormality of T cell physiology (HP:0011840)2.10172163
65Aplasia/hypoplasia of the uterus (HP:0008684)2.10144653
66CNS demyelination (HP:0007305)2.10034967
67Nephronophthisis (HP:0000090)2.09067619
68Hyperglycinemia (HP:0002154)2.08169328
69Keratoconus (HP:0000563)2.07853885
70Increased corneal curvature (HP:0100692)2.07853885
71Exercise intolerance (HP:0003546)2.03518849
72Abnormality of renal resorption (HP:0011038)2.01333374
73Stomach cancer (HP:0012126)2.00468584
74Reticulocytopenia (HP:0001896)1.99699085
75Asplenia (HP:0001746)1.99337365
76Decreased central vision (HP:0007663)1.97995914
77Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96207500
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96207500
79Abnormality of the vitamin B12 metabolism (HP:0004341)1.95658725
80Tubular atrophy (HP:0000092)1.95116016
81Leukodystrophy (HP:0002415)1.94009049
82Abnormality of the renal medulla (HP:0100957)1.92114891
83Ketosis (HP:0001946)1.91629441
84Abnormality of serine family amino acid metabolism (HP:0010894)1.88359351
85Abnormality of glycine metabolism (HP:0010895)1.88359351
86Respiratory difficulties (HP:0002880)1.87141191
87Pancytopenia (HP:0001876)1.86921494
88Absent thumb (HP:0009777)1.86805038
89Increased IgM level (HP:0003496)1.86339372
90Hypothermia (HP:0002045)1.85038122
91Polyuria (HP:0000103)1.84449237
92Thyroiditis (HP:0100646)1.83156926
93Abnormality of vitamin B metabolism (HP:0004340)1.82678588
94Hyperglycinuria (HP:0003108)1.82371681
95Abnormality of the pons (HP:0007361)1.82326382
96Abnormality of serum amino acid levels (HP:0003112)1.82218992
97Type 2 muscle fiber atrophy (HP:0003554)1.80975665
98Hypoplasia of the uterus (HP:0000013)1.79662728
99Abnormality of T cells (HP:0002843)1.79518677
100Severe combined immunodeficiency (HP:0004430)1.78988352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.79819493
2NUAK13.73223262
3VRK23.59583811
4TIE13.21753628
5FRK3.10496318
6TAOK32.85521090
7ZAK2.82989856
8TLK12.77618793
9MAP4K22.67460732
10EIF2AK32.66267777
11GRK12.22090109
12VRK12.21629663
13ADRBK22.06328445
14BMPR1B1.93471822
15MST41.82659337
16TSSK61.76345121
17PINK11.67361103
18OXSR11.64297080
19MAPKAPK31.63736593
20TXK1.63014311
21WNK41.59947793
22TEC1.58334626
23BCKDK1.55663262
24EIF2AK11.33209798
25BUB11.32937784
26PLK31.32527965
27STK391.22425667
28FES1.21285426
29ACVR1B1.20995156
30TAF11.16000065
31MAPKAPK51.14336244
32ITK1.13205518
33KIT1.09846837
34IKBKB1.09575445
35MKNK11.03793884
36PBK0.98015729
37CDK190.97740503
38KDR0.96676603
39CSNK1G30.93422876
40PHKG20.92542908
41PHKG10.92542908
42GRK60.87926404
43SYK0.86277298
44MAP4K10.85403619
45TRIM280.83751478
46DAPK10.80718498
47PASK0.80656344
48WNK30.80606964
49INSRR0.79310933
50DYRK20.78777493
51TGFBR10.78304152
52CSNK1G10.78130604
53EIF2AK20.78021682
54PDK20.76477203
55PLK20.74779835
56RPS6KA50.71084042
57PIK3CG0.71035272
58MAP2K60.70909501
59MAPK150.70151323
60PLK40.67088261
61CSNK1G20.66135962
62CDK80.65797610
63IKBKE0.64998665
64TNIK0.62523470
65GRK50.60085044
66PRKCQ0.59441687
67CAMKK20.59438043
68BTK0.59036434
69CSNK1A1L0.57941430
70TRPM70.56345300
71LYN0.55037290
72MATK0.54771020
73BMPR20.53391176
74ERBB30.53321553
75NME10.50085813
76FGFR20.49927740
77DAPK20.48546922
78ADRBK10.46503348
79NME20.45314457
80LCK0.44141934
81LIMK10.43998381
82TNK20.42677931
83MYLK0.42432455
84CCNB10.41500973
85NLK0.40709202
86RPS6KB20.39827036
87SRPK10.38901818
88MKNK20.38327229
89MAPK130.37973154
90MAP3K140.36094099
91SCYL20.35754179
92MAP3K120.35611368
93CSNK2A20.35013539
94MAP2K20.35008905
95IGF1R0.34524055
96PIK3CA0.33605740
97CSNK2A10.33131957
98PRKCA0.32417934
99PRKCG0.31184761
100PTK2B0.30988222

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.09760023
2Proteasome_Homo sapiens_hsa030503.41859265
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.32037177
4Allograft rejection_Homo sapiens_hsa053303.26098082
5Autoimmune thyroid disease_Homo sapiens_hsa053203.14980563
6Ribosome_Homo sapiens_hsa030102.77544012
7Oxidative phosphorylation_Homo sapiens_hsa001902.75742156
8Graft-versus-host disease_Homo sapiens_hsa053322.59532982
9Type I diabetes mellitus_Homo sapiens_hsa049402.55637246
10Parkinsons disease_Homo sapiens_hsa050122.27665740
11RNA polymerase_Homo sapiens_hsa030202.25613837
12Protein export_Homo sapiens_hsa030602.13917061
13Linoleic acid metabolism_Homo sapiens_hsa005911.77745618
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73618183
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.67274125
16Antigen processing and presentation_Homo sapiens_hsa046121.62780106
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59906985
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58890119
19Primary immunodeficiency_Homo sapiens_hsa053401.58666520
20Homologous recombination_Homo sapiens_hsa034401.52580207
21Rheumatoid arthritis_Homo sapiens_hsa053231.47861031
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45748004
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45623392
24Propanoate metabolism_Homo sapiens_hsa006401.39228955
25One carbon pool by folate_Homo sapiens_hsa006701.39035235
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.36230503
27Alzheimers disease_Homo sapiens_hsa050101.35673921
28RNA degradation_Homo sapiens_hsa030181.27534716
29Mismatch repair_Homo sapiens_hsa034301.26808225
30Huntingtons disease_Homo sapiens_hsa050161.26489906
31Tryptophan metabolism_Homo sapiens_hsa003801.23852976
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23833452
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18432896
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.17861024
35Phototransduction_Homo sapiens_hsa047441.16630180
36Arachidonic acid metabolism_Homo sapiens_hsa005901.13771677
37Staphylococcus aureus infection_Homo sapiens_hsa051501.13660252
38Butanoate metabolism_Homo sapiens_hsa006501.10458612
39Pyrimidine metabolism_Homo sapiens_hsa002401.08189389
40Nucleotide excision repair_Homo sapiens_hsa034201.05557538
41Sulfur metabolism_Homo sapiens_hsa009201.04140338
42Purine metabolism_Homo sapiens_hsa002301.03310795
43Non-homologous end-joining_Homo sapiens_hsa034501.01858737
44Nitrogen metabolism_Homo sapiens_hsa009101.01396607
45Fat digestion and absorption_Homo sapiens_hsa049750.99573297
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.98998309
47Basal transcription factors_Homo sapiens_hsa030220.98621147
48DNA replication_Homo sapiens_hsa030300.98084658
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97609858
50Peroxisome_Homo sapiens_hsa041460.96416789
51Fanconi anemia pathway_Homo sapiens_hsa034600.95408481
52Viral myocarditis_Homo sapiens_hsa054160.95175483
53Caffeine metabolism_Homo sapiens_hsa002320.92078452
54Cardiac muscle contraction_Homo sapiens_hsa042600.88810982
55Base excision repair_Homo sapiens_hsa034100.87612158
56Chemical carcinogenesis_Homo sapiens_hsa052040.87042448
57RNA transport_Homo sapiens_hsa030130.81703249
58Ether lipid metabolism_Homo sapiens_hsa005650.81516640
59Hematopoietic cell lineage_Homo sapiens_hsa046400.77129723
60Systemic lupus erythematosus_Homo sapiens_hsa053220.73452986
61Selenocompound metabolism_Homo sapiens_hsa004500.73121833
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73071107
63Fatty acid elongation_Homo sapiens_hsa000620.72755146
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68369889
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66782436
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66334039
67Leishmaniasis_Homo sapiens_hsa051400.65959045
68Spliceosome_Homo sapiens_hsa030400.65650571
69Retinol metabolism_Homo sapiens_hsa008300.64787225
70Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63541024
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62650774
72Fatty acid degradation_Homo sapiens_hsa000710.61812653
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.61686844
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.60182696
75Vitamin digestion and absorption_Homo sapiens_hsa049770.59287058
76Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59219293
77Metabolic pathways_Homo sapiens_hsa011000.58452779
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56818748
79Glutathione metabolism_Homo sapiens_hsa004800.56548941
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55975962
81Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52241002
82Collecting duct acid secretion_Homo sapiens_hsa049660.51206736
83Cyanoamino acid metabolism_Homo sapiens_hsa004600.49256413
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.49053182
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49030716
86Glycerolipid metabolism_Homo sapiens_hsa005610.45885342
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44416943
88Primary bile acid biosynthesis_Homo sapiens_hsa001200.43065839
89Herpes simplex infection_Homo sapiens_hsa051680.42111847
90Sulfur relay system_Homo sapiens_hsa041220.40299251
91Drug metabolism - other enzymes_Homo sapiens_hsa009830.38463085
92Folate biosynthesis_Homo sapiens_hsa007900.37077074
93Regulation of autophagy_Homo sapiens_hsa041400.36831031
94Fatty acid metabolism_Homo sapiens_hsa012120.36460303
95Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35544289
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34561447
97Olfactory transduction_Homo sapiens_hsa047400.34051520
98Epstein-Barr virus infection_Homo sapiens_hsa051690.33377593
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.33068551
100Pyruvate metabolism_Homo sapiens_hsa006200.30705237

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