ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.35255632
2	cytidine deamination (GO:0009972)	5.22870809
3	cytidine metabolic process (GO:0046087)	5.22870809
4	cytidine catabolic process (GO:0006216)	5.22870809
5	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.19710370
6	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.59169110
7	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.45456057
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.34556350
9	ATP synthesis coupled proton transport (GO:0015986)	4.34556350
10	platelet dense granule organization (GO:0060155)	3.66478115
11	respiratory chain complex IV assembly (GO:0008535)	3.53148956
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.48703988
13	mast cell activation (GO:0045576)	3.32339768
14	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.31644396
15	ribosomal small subunit assembly (GO:0000028)	3.30264468
16	electron transport chain (GO:0022900)	3.29975744
17	respiratory electron transport chain (GO:0022904)	3.29776594
18	proteasome assembly (GO:0043248)	3.26413750
19	protein neddylation (GO:0045116)	3.26139803
20	regulation of cellular amino acid metabolic process (GO:0006521)	3.24808801
21	protein complex biogenesis (GO:0070271)	3.23030128
22	cytochrome complex assembly (GO:0017004)	3.18805699
23	actin nucleation (GO:0045010)	3.16665268
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.15438787
25	water-soluble vitamin biosynthetic process (GO:0042364)	3.15328627
26	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.12627887
27	termination of RNA polymerase III transcription (GO:0006386)	3.12627887
28	mannosylation (GO:0097502)	3.10793566
29	regulation of chronic inflammatory response (GO:0002676)	3.09840062
30	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06953579
31	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	3.06283267
32	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.04818334
33	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.04096918
34	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.04096918
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.04008256
36	regulation of regulatory T cell differentiation (GO:0045589)	3.03054365
37	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	3.02085154
38	negative T cell selection (GO:0043383)	3.01916763
39	mast cell activation involved in immune response (GO:0002279)	3.00901868
40	mast cell degranulation (GO:0043303)	3.00901868
41	negative regulation of T cell apoptotic process (GO:0070233)	3.00318995
42	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.99362510
43	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.95676366
44	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.95676366
45	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.95676366
46	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.93286630
47	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.93286630
48	kynurenine metabolic process (GO:0070189)	2.92723615
49	tryptophan catabolic process (GO:0006569)	2.92302024
50	indole-containing compound catabolic process (GO:0042436)	2.92302024
51	indolalkylamine catabolic process (GO:0046218)	2.92302024
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.91797202
53	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.89423130
54	rRNA modification (GO:0000154)	2.83913354
55	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.82454347
56	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.81201801
57	positive T cell selection (GO:0043368)	2.79351467
58	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.78952505
59	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.76995833
60	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.76995833
61	sequestering of actin monomers (GO:0042989)	2.75638060
62	positive thymic T cell selection (GO:0045059)	2.73941592
63	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.73216371
64	GPI anchor metabolic process (GO:0006505)	2.72511855
65	peptidyl-histidine modification (GO:0018202)	2.72277980
66	regulation of isotype switching to IgG isotypes (GO:0048302)	2.71006262
67	hydrogen ion transmembrane transport (GO:1902600)	2.69997698
68	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.69971842
69	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.69971842
70	NADH dehydrogenase complex assembly (GO:0010257)	2.69971842
71	negative regulation of mast cell activation (GO:0033004)	2.69831851
72	iron-sulfur cluster assembly (GO:0016226)	2.69823857
73	metallo-sulfur cluster assembly (GO:0031163)	2.69823857
74	positive regulation of calcium-mediated signaling (GO:0050850)	2.69453423
75	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.68278119
76	GPI anchor biosynthetic process (GO:0006506)	2.67949231
77	regulation of B cell receptor signaling pathway (GO:0050855)	2.67359462
78	negative regulation of ligase activity (GO:0051352)	2.66930054
79	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.66930054
80	pyrimidine nucleoside catabolic process (GO:0046135)	2.66157904
81	proton transport (GO:0015992)	2.65014903
82	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.63765320
83	regulation of T cell receptor signaling pathway (GO:0050856)	2.63105008
84	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.62917052
85	T cell receptor signaling pathway (GO:0050852)	2.61970097
86	cellular response to interleukin-15 (GO:0071350)	2.61615428
87	GTP biosynthetic process (GO:0006183)	2.60996247
88	tryptophan metabolic process (GO:0006568)	2.60984500
89	regulation of T cell tolerance induction (GO:0002664)	2.60742780
90	hydrogen transport (GO:0006818)	2.60576402
91	T cell migration (GO:0072678)	2.60455820
92	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.58885520
93	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.58697874
94	regulation of interleukin-8 secretion (GO:2000482)	2.58543151
95	indolalkylamine metabolic process (GO:0006586)	2.58263664
96	regulation of T cell mediated cytotoxicity (GO:0001914)	2.57463385
97	regulation of alpha-beta T cell proliferation (GO:0046640)	2.56542294
98	positive regulation of tolerance induction (GO:0002645)	2.56342669
99	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.55109900
100	negative thymic T cell selection (GO:0045060)	2.55044840

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.40862377
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.40297473
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.19958036
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.15155092
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.04576405
6	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.99641746
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.96498864
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.93593191
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.92731349
10	VDR_22108803_ChIP-Seq_LS180_Human	2.89184797
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.71728555
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.71682116
13	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.67517666
14	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.66928492
15	VDR_23849224_ChIP-Seq_CD4+_Human	2.63492779
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.48333907
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.39524710
18	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.35806417
19	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27516396
20	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.19032165
21	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16993408
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.07053115
23	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.03674471
24	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01344255
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.00028093
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.97658854
27	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.94821728
28	GATA3_26560356_Chip-Seq_TH2_Human	1.79156668
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.78762247
30	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74432790
31	MYB_26560356_Chip-Seq_TH2_Human	1.67634177
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.65796032
33	EWS_26573619_Chip-Seq_HEK293_Human	1.62364712
34	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.60100157
35	TP53_22573176_ChIP-Seq_HFKS_Human	1.46613973
36	FUS_26573619_Chip-Seq_HEK293_Human	1.45243546
37	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.44780326
38	TAF15_26573619_Chip-Seq_HEK293_Human	1.42126017
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.42038183
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.42038183
41	MYC_18940864_ChIP-ChIP_HL60_Human	1.37360263
42	AR_20517297_ChIP-Seq_VCAP_Human	1.36118714
43	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.32155922
44	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31125926
45	GATA3_27048872_Chip-Seq_THYMUS_Human	1.30207277
46	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.30199573
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.30199573
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29810319
49	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.29746260
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27470000
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.26541914
52	P300_19829295_ChIP-Seq_ESCs_Human	1.25232630
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.25201162
54	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.25196833
55	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.24205640
56	RUNX_20019798_ChIP-Seq_JUKART_Human	1.24196060
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22170723
58	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.20825803
59	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.19861285
60	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19251727
61	SOX2_19829295_ChIP-Seq_ESCs_Human	1.19229456
62	NANOG_19829295_ChIP-Seq_ESCs_Human	1.19229456
63	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.19109427
64	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.17870070
65	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.17398093
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.15621772
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.13585324
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.13095554
69	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.12671807
70	NCOR_22424771_ChIP-Seq_293T_Human	1.12404310
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.12009201
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.10638251
73	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10495821
74	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.10281345
75	HTT_18923047_ChIP-ChIP_STHdh_Human	1.09995821
76	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.09841879
77	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.08962258
78	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.08516924
79	ERG_20517297_ChIP-Seq_VCAP_Human	1.06962878
80	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.04961376
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.04945587
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03774717
83	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.02149705
84	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.02008745
85	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.01751651
86	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01237867
87	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.00828891
88	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.00544569
89	TAF2_19829295_ChIP-Seq_ESCs_Human	1.00032500
90	GATA3_26560356_Chip-Seq_TH1_Human	0.98997946
91	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.98711056
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.98446083
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.97449164
94	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.96152988
95	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96080365
96	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.95373619
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95220702
98	NANOG_20526341_ChIP-Seq_ESCs_Human	0.94389206
99	GBX2_23144817_ChIP-Seq_PC3_Human	0.94315671
100	BCAT_22108803_ChIP-Seq_LS180_Human	0.93411793

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.43188418
2	MP0001835_abnormal_antigen_presentation	3.90163427
3	MP0009785_altered_susceptibility_to	2.60603224
4	MP0002166_altered_tumor_susceptibility	2.43610233
5	MP0004147_increased_porphyrin_level	2.39178857
6	MP0006072_abnormal_retinal_apoptosis	2.31870245
7	MP0003195_calcinosis	2.26348497
8	MP0003763_abnormal_thymus_physiology	2.21165149
9	MP0001800_abnormal_humoral_immune	2.17161268
10	MP0002148_abnormal_hypersensitivity_rea	2.14610998
11	MP0005000_abnormal_immune_tolerance	2.14211332
12	MP0000685_abnormal_immune_system	1.97264128
13	MP0009333_abnormal_splenocyte_physiolog	1.96983227
14	MP0002006_tumorigenesis	1.95084628
15	MP0008875_abnormal_xenobiotic_pharmacok	1.92426199
16	MP0002138_abnormal_hepatobiliary_system	1.87551166
17	MP0003646_muscle_fatigue	1.84959223
18	MP0005084_abnormal_gallbladder_morpholo	1.83734988
19	MP0003724_increased_susceptibility_to	1.82635497
20	MP0002723_abnormal_immune_serum	1.82142461
21	MP0005387_immune_system_phenotype	1.80523695
22	MP0001790_abnormal_immune_system	1.80523695
23	MP0008872_abnormal_physiological_respon	1.78711115
24	MP0002420_abnormal_adaptive_immunity	1.76785329
25	MP0001873_stomach_inflammation	1.74764792
26	MP0001819_abnormal_immune_cell	1.73621074
27	MP0003866_abnormal_defecation	1.71914318
28	MP0005551_abnormal_eye_electrophysiolog	1.71415445
29	MP0002102_abnormal_ear_morphology	1.68304159
30	MP0005075_abnormal_melanosome_morpholog	1.62553164
31	MP0002452_abnormal_antigen_presenting	1.59499318
32	MP0005253_abnormal_eye_physiology	1.58583634
33	MP0005645_abnormal_hypothalamus_physiol	1.58137190
34	MP0006292_abnormal_olfactory_placode	1.56921152
35	MP0008877_abnormal_DNA_methylation	1.56232343
36	MP0002876_abnormal_thyroid_physiology	1.55402965
37	MP0002837_dystrophic_cardiac_calcinosis	1.54591791
38	MP0003786_premature_aging	1.53855162
39	MP0005377_hearing/vestibular/ear_phenot	1.53671319
40	MP0003878_abnormal_ear_physiology	1.53671319
41	MP0001968_abnormal_touch/_nociception	1.53639678
42	MP0002736_abnormal_nociception_after	1.52390835
43	MP0005025_abnormal_response_to	1.46227828
44	MP0009764_decreased_sensitivity_to	1.44928927
45	MP0004142_abnormal_muscle_tone	1.42317574
46	MP0001501_abnormal_sleep_pattern	1.38762549
47	MP0002405_respiratory_system_inflammati	1.34877989
48	MP0003787_abnormal_imprinting	1.33151619
49	MP0000372_irregular_coat_pigmentation	1.30813255
50	MP0002398_abnormal_bone_marrow	1.30246778
51	MP0010155_abnormal_intestine_physiology	1.28133963
52	MP0000716_abnormal_immune_system	1.27978218
53	MP0005646_abnormal_pituitary_gland	1.25817635
54	MP0006036_abnormal_mitochondrial_physio	1.24192656
55	MP0003252_abnormal_bile_duct	1.22517864
56	MP0002277_abnormal_respiratory_mucosa	1.22085271
57	MP0000689_abnormal_spleen_morphology	1.21941439
58	MP0008058_abnormal_DNA_repair	1.21522069
59	MP0001845_abnormal_inflammatory_respons	1.20835908
60	MP0006082_CNS_inflammation	1.20104487
61	MP0008995_early_reproductive_senescence	1.19666189
62	MP0004145_abnormal_muscle_electrophysio	1.18452052
63	MP0002163_abnormal_gland_morphology	1.12384706
64	MP0003436_decreased_susceptibility_to	1.10342646
65	MP0005389_reproductive_system_phenotype	1.09630139
66	MP0001905_abnormal_dopamine_level	1.06569639
67	MP0000569_abnormal_digit_pigmentation	1.04857057
68	MP0002693_abnormal_pancreas_physiology	1.04806225
69	MP0003806_abnormal_nucleotide_metabolis	1.04348743
70	MP0001764_abnormal_homeostasis	1.03121006
71	MP0001986_abnormal_taste_sensitivity	1.01951221
72	MP0001919_abnormal_reproductive_system	1.01479070
73	MP0002722_abnormal_immune_system	1.00690437
74	MP0002429_abnormal_blood_cell	0.99761050
75	MP0000703_abnormal_thymus_morphology	0.98292148
76	MP0005636_abnormal_mineral_homeostasis	0.96131129
77	MP0002419_abnormal_innate_immunity	0.94995913
78	MP0005410_abnormal_fertilization	0.90790260
79	MP0002160_abnormal_reproductive_system	0.90100379
80	MP0003186_abnormal_redox_activity	0.89746589
81	MP0002272_abnormal_nervous_system	0.88775959
82	MP0008469_abnormal_protein_level	0.88138245
83	MP0002254_reproductive_system_inflammat	0.85981634
84	MP0003011_delayed_dark_adaptation	0.85737048
85	MP0009379_abnormal_foot_pigmentation	0.84314353
86	MP0002095_abnormal_skin_pigmentation	0.84237606
87	MP0002933_joint_inflammation	0.83908236
88	MP0004885_abnormal_endolymph	0.83737529
89	MP0005379_endocrine/exocrine_gland_phen	0.82126237
90	MP0005174_abnormal_tail_pigmentation	0.77982919
91	MP0005464_abnormal_platelet_physiology	0.76835792
92	MP0003880_abnormal_central_pattern	0.76528075
93	MP0009643_abnormal_urine_homeostasis	0.76114591
94	MP0003045_fibrosis	0.75302674
95	MP0001765_abnormal_ion_homeostasis	0.72852908
96	MP0003718_maternal_effect	0.71810543
97	MP0009763_increased_sensitivity_to	0.71244027
98	MP0005332_abnormal_amino_acid	0.70965588
99	MP0001970_abnormal_pain_threshold	0.70622033
100	MP0001984_abnormal_olfaction	0.69941758

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplastic anemia (HP:0001915)	4.46296958
2	Mitochondrial inheritance (HP:0001427)	3.88737643
3	Increased hepatocellular lipid droplets (HP:0006565)	3.82970068
4	IgG deficiency (HP:0004315)	3.79132831
5	Hepatocellular necrosis (HP:0001404)	3.67954154
6	Increased CSF lactate (HP:0002490)	3.66650781
7	Acute necrotizing encephalopathy (HP:0006965)	3.64253015
8	Stomatitis (HP:0010280)	3.57271564
9	Lipid accumulation in hepatocytes (HP:0006561)	3.57028867
10	Elevated erythrocyte sedimentation rate (HP:0003565)	3.46645850
11	Pancreatic cysts (HP:0001737)	3.38579104
12	Hepatic necrosis (HP:0002605)	3.32795668
13	Hypoproteinemia (HP:0003075)	3.31308041
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.24322471
15	Progressive macrocephaly (HP:0004481)	3.15920846
16	Congenital stationary night blindness (HP:0007642)	3.14804541
17	Severe combined immunodeficiency (HP:0004430)	3.12500368
18	Acute encephalopathy (HP:0006846)	3.12318376
19	Abolished electroretinogram (ERG) (HP:0000550)	3.05156928
20	T lymphocytopenia (HP:0005403)	3.00936603
21	Renal Fanconi syndrome (HP:0001994)	3.00113327
22	Increased intramyocellular lipid droplets (HP:0012240)	2.97318779
23	3-Methylglutaconic aciduria (HP:0003535)	2.95774444
24	Attenuation of retinal blood vessels (HP:0007843)	2.89526914
25	Abnormality of T cell number (HP:0011839)	2.85064955
26	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.84724811
27	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.84724811
28	Abnormality of midbrain morphology (HP:0002418)	2.83930378
29	Molar tooth sign on MRI (HP:0002419)	2.83930378
30	Pancreatic fibrosis (HP:0100732)	2.73372133
31	Thyroiditis (HP:0100646)	2.72823352
32	Increased serum lactate (HP:0002151)	2.72811830
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.71935108
34	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.63488799
35	Cerebral edema (HP:0002181)	2.62940826
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.57976052
37	Abnormality of T cells (HP:0002843)	2.57147828
38	Exertional dyspnea (HP:0002875)	2.56389361
39	True hermaphroditism (HP:0010459)	2.53968659
40	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.53267587
41	Panhypogammaglobulinemia (HP:0003139)	2.51107889
42	Lactic acidosis (HP:0003128)	2.49078969
43	Abnormality of alanine metabolism (HP:0010916)	2.46916394
44	Hyperalaninemia (HP:0003348)	2.46916394
45	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.46916394
46	Methylmalonic acidemia (HP:0002912)	2.46418454
47	Increased muscle lipid content (HP:0009058)	2.45292075
48	Abnormality of the prostate (HP:0008775)	2.44456706
49	Optic disc pallor (HP:0000543)	2.43816505
50	Hypothermia (HP:0002045)	2.42408620
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.38207778
52	Congenital, generalized hypertrichosis (HP:0004540)	2.35146937
53	Abnormality of the renal cortex (HP:0011035)	2.34049866
54	Nephronophthisis (HP:0000090)	2.30709579
55	Combined immunodeficiency (HP:0005387)	2.29541884
56	Recurrent cutaneous fungal infections (HP:0011370)	2.28960687
57	Chronic mucocutaneous candidiasis (HP:0002728)	2.28960687
58	Decreased central vision (HP:0007663)	2.26618352
59	Autoimmune hemolytic anemia (HP:0001890)	2.24347525
60	Methylmalonic aciduria (HP:0012120)	2.18891594
61	Chronic diarrhea (HP:0002028)	2.18365154
62	Increased IgM level (HP:0003496)	2.17313499
63	Lethargy (HP:0001254)	2.16001299
64	Type II lissencephaly (HP:0007260)	2.14031390
65	Polydipsia (HP:0001959)	2.13414495
66	Abnormal drinking behavior (HP:0030082)	2.13414495
67	Abnormality of T cell physiology (HP:0011840)	2.12113619
68	Pancytopenia (HP:0001876)	2.11030126
69	Renal cortical cysts (HP:0000803)	2.07178343
70	Abnormality of eosinophils (HP:0001879)	2.06536159
71	Abnormality of the renal medulla (HP:0100957)	2.00039681
72	Respiratory failure (HP:0002878)	1.99715441
73	Hypoalbuminemia (HP:0003073)	1.99148790
74	Abnormal albumin level (HP:0012116)	1.99148790
75	Encephalitis (HP:0002383)	1.97843470
76	Ketosis (HP:0001946)	1.97538968
77	Constricted visual fields (HP:0001133)	1.96160278
78	Generalized aminoaciduria (HP:0002909)	1.95930655
79	Ketoacidosis (HP:0001993)	1.93048894
80	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.90358928
81	Abnormality of B cell number (HP:0010975)	1.89365785
82	Abnormality of renal resorption (HP:0011038)	1.88649088
83	Abnormal number of erythroid precursors (HP:0012131)	1.88596734
84	Dicarboxylic aciduria (HP:0003215)	1.87921018
85	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.87921018
86	Glycosuria (HP:0003076)	1.78790099
87	Abnormality of urine glucose concentration (HP:0011016)	1.78790099
88	Hyperphosphaturia (HP:0003109)	1.78590851
89	Cystic liver disease (HP:0006706)	1.76982236
90	Polyuria (HP:0000103)	1.76595616
91	Respiratory difficulties (HP:0002880)	1.75892228
92	Cerebral palsy (HP:0100021)	1.75551127
93	Keratoconus (HP:0000563)	1.74878145
94	Increased corneal curvature (HP:0100692)	1.74878145
95	Type 2 muscle fiber atrophy (HP:0003554)	1.72222178
96	Abnormality of serum amino acid levels (HP:0003112)	1.72042455
97	Exercise intolerance (HP:0003546)	1.71722760
98	Eosinophilia (HP:0001880)	1.71313626
99	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.69594139
100	Cerebellar dysplasia (HP:0007033)	1.68503685

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.34893020
2	MAP4K2	2.94971705
3	FRK	2.79899238
4	KDR	2.72061558
5	BCKDK	2.53867764
6	ZAK	2.51869524
7	TAOK3	2.51474653
8	ADRBK2	2.42102601
9	TLK1	2.41105433
10	MAP4K1	2.35565768
11	NUAK1	2.31923256
12	VRK2	2.17199885
13	TESK2	2.12388447
14	MST4	2.02361624
15	MAP3K12	1.99829258
16	GRK1	1.98413282
17	CDK19	1.87415103
18	ITK	1.75309997
19	TEC	1.69332404
20	FES	1.57831442
21	VRK1	1.52399000
22	OXSR1	1.50359240
23	WNK4	1.46237103
24	BMPR2	1.42136264
25	SYK	1.39486583
26	TIE1	1.37694168
27	SCYL2	1.32483098
28	GRK6	1.32063046
29	PINK1	1.30412569
30	WNK3	1.24267615
31	IKBKB	1.18364743
32	NME1	1.17095082
33	STK16	1.10975621
34	EIF2AK3	1.10549702
35	BTK	1.09883560
36	BMPR1B	1.03063358
37	KIT	1.01744128
38	CSF1R	1.00922530
39	PRKCQ	0.99579766
40	ERBB3	0.96737434
41	BUB1	0.96172178
42	MAP2K6	0.95693815
43	LCK	0.94241282
44	MYLK	0.93720643
45	PIK3CG	0.92262669
46	DAPK1	0.90770111
47	CAMKK2	0.88870572
48	ZAP70	0.88321736
49	LYN	0.84730629
50	STK39	0.84131360
51	INSRR	0.83271110
52	RPS6KA5	0.83246126
53	TNK2	0.77691087
54	TRPM7	0.77550811
55	PHKG2	0.77393995
56	PHKG1	0.77393995
57	TRIM28	0.76025781
58	BRSK2	0.74851011
59	IKBKE	0.72751360
60	ADRBK1	0.71414976
61	MAPKAPK3	0.68820762
62	CSNK1G3	0.63123372
63	DAPK2	0.60468280
64	CSNK1G1	0.59390495
65	PASK	0.58902851
66	MAP3K14	0.58885315
67	DYRK2	0.58645345
68	CSK	0.57788993
69	MUSK	0.56066131
70	NLK	0.54081974
71	PIK3CA	0.53993811
72	PLK3	0.51771889
73	CSNK1G2	0.51563214
74	IGF1R	0.50974613
75	GRK7	0.50349979
76	RPS6KA4	0.48905794
77	PIM1	0.48362929
78	OBSCN	0.47408684
79	HCK	0.46211452
80	PRKCE	0.45493146
81	MKNK1	0.44605991
82	CSNK1A1L	0.43134087
83	LIMK1	0.42287105
84	FLT3	0.41526541
85	RIPK4	0.39343380
86	PTK2B	0.39305022
87	NEK1	0.38706245
88	PRKCA	0.37702806
89	ABL1	0.35878632
90	DAPK3	0.35432024
91	JAK3	0.35092363
92	PRKACA	0.35019125
93	MAP3K11	0.33548001
94	CAMK2A	0.33350941
95	SRPK1	0.32775070
96	ATR	0.32544947
97	MAPK13	0.32367096
98	CSNK2A1	0.30242001
99	PDK2	0.30182060
100	CSNK2A2	0.29214102

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.98602314
2	Asthma_Homo sapiens_hsa05310	3.29323953
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.21801079
4	Allograft rejection_Homo sapiens_hsa05330	3.20856819
5	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15556316
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.06776401
7	Graft-versus-host disease_Homo sapiens_hsa05332	2.94907753
8	Type I diabetes mellitus_Homo sapiens_hsa04940	2.84127094
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.66461636
10	Parkinsons disease_Homo sapiens_hsa05012	2.52562230
11	RNA polymerase_Homo sapiens_hsa03020	2.51624851
12	Ribosome_Homo sapiens_hsa03010	2.43024142
13	Protein export_Homo sapiens_hsa03060	2.33449383
14	Antigen processing and presentation_Homo sapiens_hsa04612	2.23401148
15	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.88876734
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.88154264
17	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.84810885
18	Phototransduction_Homo sapiens_hsa04744	1.75246481
19	Alzheimers disease_Homo sapiens_hsa05010	1.59749713
20	Rheumatoid arthritis_Homo sapiens_hsa05323	1.57547636
21	Huntingtons disease_Homo sapiens_hsa05016	1.52685607
22	Homologous recombination_Homo sapiens_hsa03440	1.48695384
23	RNA degradation_Homo sapiens_hsa03018	1.47466640
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.46117737
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42774130
26	Caffeine metabolism_Homo sapiens_hsa00232	1.40336891
27	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.38325903
28	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32438673
29	Linoleic acid metabolism_Homo sapiens_hsa00591	1.30109839
30	Propanoate metabolism_Homo sapiens_hsa00640	1.24412793
31	Nitrogen metabolism_Homo sapiens_hsa00910	1.23602763
32	One carbon pool by folate_Homo sapiens_hsa00670	1.19843776
33	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.14412509
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.13239924
35	Viral myocarditis_Homo sapiens_hsa05416	1.07770822
36	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.04873100
37	Tryptophan metabolism_Homo sapiens_hsa00380	1.01679115
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.00274641
39	Butanoate metabolism_Homo sapiens_hsa00650	0.97850102
40	Purine metabolism_Homo sapiens_hsa00230	0.94410674
41	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.91399393
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90542574
43	Basal transcription factors_Homo sapiens_hsa03022	0.90388459
44	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.89487308
45	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88306158
46	Peroxisome_Homo sapiens_hsa04146	0.87644548
47	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.87474157
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.84656182
49	Regulation of autophagy_Homo sapiens_hsa04140	0.83964802
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.83606835
51	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.82976517
52	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79386307
53	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77332110
54	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.76982867
55	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76065464
56	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.75637514
57	Olfactory transduction_Homo sapiens_hsa04740	0.75218836
58	RNA transport_Homo sapiens_hsa03013	0.73053334
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72471343
60	Sulfur metabolism_Homo sapiens_hsa00920	0.72464769
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.69031413
62	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.67882324
63	Spliceosome_Homo sapiens_hsa03040	0.66354053
64	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64673366
65	Mismatch repair_Homo sapiens_hsa03430	0.62885450
66	Ether lipid metabolism_Homo sapiens_hsa00565	0.62456173
67	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58015039
68	Leishmaniasis_Homo sapiens_hsa05140	0.57974349
69	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57726805
70	Nucleotide excision repair_Homo sapiens_hsa03420	0.57212984
71	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55396057
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53216908
73	Selenocompound metabolism_Homo sapiens_hsa00450	0.51534141
74	Retinol metabolism_Homo sapiens_hsa00830	0.51481459
75	Measles_Homo sapiens_hsa05162	0.48469009
76	Metabolic pathways_Homo sapiens_hsa01100	0.47624003
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.47389475
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44133259
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.43329111
80	Herpes simplex infection_Homo sapiens_hsa05168	0.42848018
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42719472
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.41981650
83	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36131164
84	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.35317932
85	Base excision repair_Homo sapiens_hsa03410	0.32810616
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.31409094
87	Non-homologous end-joining_Homo sapiens_hsa03450	0.29999462
88	Taste transduction_Homo sapiens_hsa04742	0.27666430
89	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.27552994
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.25196102
91	DNA replication_Homo sapiens_hsa03030	0.24725637
92	Folate biosynthesis_Homo sapiens_hsa00790	0.24661529
93	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.24493627
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.24461702
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.22616484
96	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.21829854
97	Glutathione metabolism_Homo sapiens_hsa00480	0.21664241
98	Fat digestion and absorption_Homo sapiens_hsa04975	0.21126934
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19984141
100	Legionellosis_Homo sapiens_hsa05134	0.19394222

RPL3P6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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