RPL3P7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.44433178
2ATP synthesis coupled proton transport (GO:0015986)5.19850444
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.19850444
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.04401248
5cytidine deamination (GO:0009972)4.85152749
6cytidine metabolic process (GO:0046087)4.85152749
7cytidine catabolic process (GO:0006216)4.85152749
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.63401701
9ribosomal small subunit assembly (GO:0000028)4.34002765
10pyrimidine ribonucleoside catabolic process (GO:0046133)4.14509887
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.13399040
12protein complex biogenesis (GO:0070271)4.00238584
13respiratory electron transport chain (GO:0022904)3.86519455
14electron transport chain (GO:0022900)3.85231714
15water-soluble vitamin biosynthetic process (GO:0042364)3.76028505
16protein neddylation (GO:0045116)3.73618502
17mitochondrial respiratory chain complex assembly (GO:0033108)3.67834503
18cytochrome complex assembly (GO:0017004)3.65876312
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.65786462
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.65786462
21respiratory chain complex IV assembly (GO:0008535)3.65416242
22viral transcription (GO:0019083)3.54341428
23chaperone-mediated protein transport (GO:0072321)3.52304296
24translational termination (GO:0006415)3.47513302
25SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.35864147
26mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35439242
27mitochondrial respiratory chain complex I assembly (GO:0032981)3.35439242
28NADH dehydrogenase complex assembly (GO:0010257)3.35439242
29positive regulation of defense response to virus by host (GO:0002230)3.32616066
30protein targeting to ER (GO:0045047)3.30243573
31cotranslational protein targeting to membrane (GO:0006613)3.29718030
32nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.26969814
33translational elongation (GO:0006414)3.22622515
34regulation of activation of Janus kinase activity (GO:0010533)3.21075725
35response to pheromone (GO:0019236)3.16185921
36exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16020676
37protein localization to endoplasmic reticulum (GO:0070972)3.16012958
38platelet dense granule organization (GO:0060155)3.14816084
39establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11503448
40ATP biosynthetic process (GO:0006754)3.09502493
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.08613849
42purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.07962483
43purine nucleoside triphosphate biosynthetic process (GO:0009145)3.07364682
44GTP biosynthetic process (GO:0006183)3.03085784
45proteasome assembly (GO:0043248)3.01811550
46hydrogen ion transmembrane transport (GO:1902600)3.00713765
47maturation of SSU-rRNA (GO:0030490)2.96434958
48regulation of regulatory T cell differentiation (GO:0045589)2.95838083
49behavioral response to nicotine (GO:0035095)2.94190168
50positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.94095939
51positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94004767
52pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.92316091
53proton transport (GO:0015992)2.87406692
54regulation of cellular amino acid metabolic process (GO:0006521)2.86810774
55translation (GO:0006412)2.86389661
56ribosomal small subunit biogenesis (GO:0042274)2.84632218
57pseudouridine synthesis (GO:0001522)2.83705932
58positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83634723
59mannosylation (GO:0097502)2.83125786
60hydrogen transport (GO:0006818)2.81489684
61GPI anchor metabolic process (GO:0006505)2.81065589
62positive regulation of prostaglandin secretion (GO:0032308)2.72957197
63transcription elongation from RNA polymerase III promoter (GO:0006385)2.71466226
64termination of RNA polymerase III transcription (GO:0006386)2.71466226
65positive regulation of alpha-beta T cell proliferation (GO:0046641)2.71115381
66actin nucleation (GO:0045010)2.68014515
67DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.67732641
68positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.66997792
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.66966493
70Arp2/3 complex-mediated actin nucleation (GO:0034314)2.66550120
71GPI anchor biosynthetic process (GO:0006506)2.66538821
72fucose catabolic process (GO:0019317)2.65749245
73L-fucose metabolic process (GO:0042354)2.65749245
74L-fucose catabolic process (GO:0042355)2.65749245
75regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.65684970
76regulation of T cell mediated cytotoxicity (GO:0001914)2.64526982
77ribonucleoside triphosphate biosynthetic process (GO:0009201)2.60678872
78negative regulation of T cell apoptotic process (GO:0070233)2.60475185
79regulation of memory T cell differentiation (GO:0043380)2.59871529
80cellular ketone body metabolic process (GO:0046950)2.59577327
81preassembly of GPI anchor in ER membrane (GO:0016254)2.58942247
82regulation of chronic inflammatory response (GO:0002676)2.58721600
83ribosomal large subunit biogenesis (GO:0042273)2.58661095
84signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.57681917
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.57681917
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.57681917
87viral life cycle (GO:0019058)2.57510841
88translational initiation (GO:0006413)2.56067141
89regulation of isotype switching to IgG isotypes (GO:0048302)2.55344177
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.55125361
91intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.55125361
92rRNA modification (GO:0000154)2.52421763
93cellular component biogenesis (GO:0044085)2.52392289
94peptidyl-histidine modification (GO:0018202)2.52365211
95cellular protein complex disassembly (GO:0043624)2.51203418
96positive regulation of T-helper 1 type immune response (GO:0002827)2.51117600
97regulation of T cell receptor signaling pathway (GO:0050856)2.50976613
98regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.50269065
99positive regulation of fatty acid transport (GO:2000193)2.49891125
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49195960

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.68009229
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.38457188
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.38274422
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35379707
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.18705036
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93050090
7ZNF274_21170338_ChIP-Seq_K562_Hela2.80419260
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.79803002
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.72390946
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66188322
11VDR_22108803_ChIP-Seq_LS180_Human2.62289656
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.60749310
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58866676
14VDR_23849224_ChIP-Seq_CD4+_Human2.53920630
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.37204556
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.36088403
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.34893533
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29888137
19IGF1R_20145208_ChIP-Seq_DFB_Human2.15833316
20SRF_21415370_ChIP-Seq_HL-1_Mouse1.99760500
21FOXP3_21729870_ChIP-Seq_TREG_Human1.98512220
22FLI1_27457419_Chip-Seq_LIVER_Mouse1.92125185
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84338354
24ELK1_19687146_ChIP-ChIP_HELA_Human1.83178529
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78811536
26MYC_18940864_ChIP-ChIP_HL60_Human1.76328165
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76133836
28NOTCH1_21737748_ChIP-Seq_TLL_Human1.74845203
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.63228672
30EWS_26573619_Chip-Seq_HEK293_Human1.56067149
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54510365
32TP53_22573176_ChIP-Seq_HFKS_Human1.53261992
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52972158
34GATA3_26560356_Chip-Seq_TH2_Human1.50979676
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.47608459
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47608459
37AR_20517297_ChIP-Seq_VCAP_Human1.43938471
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41860882
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39883813
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.32194059
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.30721143
42NANOG_19829295_ChIP-Seq_ESCs_Human1.29929467
43SOX2_19829295_ChIP-Seq_ESCs_Human1.29929467
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28982719
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.26300192
46HTT_18923047_ChIP-ChIP_STHdh_Human1.25629729
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25284755
48MYB_26560356_Chip-Seq_TH2_Human1.23622767
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23442054
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.23438670
51NCOR_22424771_ChIP-Seq_293T_Human1.23134133
52TAF2_19829295_ChIP-Seq_ESCs_Human1.22174178
53NANOG_20526341_ChIP-Seq_ESCs_Human1.20906945
54ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20749377
55FUS_26573619_Chip-Seq_HEK293_Human1.20613044
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.20368499
57YY1_21170310_ChIP-Seq_MESCs_Mouse1.19576997
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.17975950
59ER_23166858_ChIP-Seq_MCF-7_Human1.16316947
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.15709087
61P300_19829295_ChIP-Seq_ESCs_Human1.15095416
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.14994014
63MYC_18555785_ChIP-Seq_MESCs_Mouse1.14688776
64TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14527388
65PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.14420783
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13685241
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.13556952
68RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.12213692
69ERG_20517297_ChIP-Seq_VCAP_Human1.12055606
70EZH2_22144423_ChIP-Seq_EOC_Human1.11540177
71IRF1_19129219_ChIP-ChIP_H3396_Human1.10098801
72CBP_20019798_ChIP-Seq_JUKART_Human1.09738224
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09738224
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.09325694
75MYC_19829295_ChIP-Seq_ESCs_Human1.09174705
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07671281
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06772340
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06644584
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06286726
80CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04954918
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04729273
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04441523
83GATA3_27048872_Chip-Seq_THYMUS_Human1.03533871
84GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.02649364
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02227081
86AUTS2_25519132_ChIP-Seq_293T-REX_Human1.00656312
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00493860
88CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99351277
89RUNX_20019798_ChIP-Seq_JUKART_Human0.99295945
90NFE2_27457419_Chip-Seq_LIVER_Mouse0.98776993
91HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98475399
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97765565
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.97498546
94GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.96303404
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96036882
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95742287
97FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95356182
98ERA_21632823_ChIP-Seq_H3396_Human0.94779953
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94015292
100GATA6_21074721_ChIP-Seq_CACO-2_Human0.93889769

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.92128200
2MP0001835_abnormal_antigen_presentation2.66097046
3MP0009379_abnormal_foot_pigmentation2.58185490
4MP0009785_altered_susceptibility_to2.40643490
5MP0006072_abnormal_retinal_apoptosis2.28035856
6MP0008877_abnormal_DNA_methylation2.24211936
7MP0002102_abnormal_ear_morphology2.21839255
8MP0002163_abnormal_gland_morphology2.18744379
9MP0005075_abnormal_melanosome_morpholog2.14286271
10MP0002837_dystrophic_cardiac_calcinosis2.11579345
11MP0005645_abnormal_hypothalamus_physiol2.11160362
12MP0003646_muscle_fatigue2.01947883
13MP0006292_abnormal_olfactory_placode2.01902509
14MP0008875_abnormal_xenobiotic_pharmacok2.01261395
15MP0002876_abnormal_thyroid_physiology1.89846157
16MP0002148_abnormal_hypersensitivity_rea1.87350334
17MP0005379_endocrine/exocrine_gland_phen1.85110103
18MP0004147_increased_porphyrin_level1.84010778
19MP0008872_abnormal_physiological_respon1.81523045
20MP0002638_abnormal_pupillary_reflex1.79978380
21MP0000372_irregular_coat_pigmentation1.74302553
22MP0003195_calcinosis1.74229186
23MP0005000_abnormal_immune_tolerance1.70980398
24MP0005646_abnormal_pituitary_gland1.70559644
25MP0005084_abnormal_gallbladder_morpholo1.68181939
26MP0003787_abnormal_imprinting1.67192100
27MP0003011_delayed_dark_adaptation1.66676194
28MP0001800_abnormal_humoral_immune1.64355188
29MP0009333_abnormal_splenocyte_physiolog1.63762803
30MP0002166_altered_tumor_susceptibility1.63084776
31MP0005389_reproductive_system_phenotype1.60185845
32MP0003763_abnormal_thymus_physiology1.55201721
33MP0001919_abnormal_reproductive_system1.55085468
34MP0005253_abnormal_eye_physiology1.54190233
35MP0005551_abnormal_eye_electrophysiolog1.53967503
36MP0004145_abnormal_muscle_electrophysio1.47212475
37MP0000685_abnormal_immune_system1.45813262
38MP0002723_abnormal_immune_serum1.42739918
39MP0002138_abnormal_hepatobiliary_system1.39508615
40MP0002420_abnormal_adaptive_immunity1.37291996
41MP0005387_immune_system_phenotype1.37185348
42MP0001790_abnormal_immune_system1.37185348
43MP0006036_abnormal_mitochondrial_physio1.34279239
44MP0001819_abnormal_immune_cell1.34067850
45MP0002006_tumorigenesis1.33838926
46MP0001905_abnormal_dopamine_level1.33774624
47MP0001873_stomach_inflammation1.33707593
48MP0003866_abnormal_defecation1.31703375
49MP0005025_abnormal_response_to1.30735569
50MP0004142_abnormal_muscle_tone1.29090978
51MP0001968_abnormal_touch/_nociception1.28935712
52MP0002277_abnormal_respiratory_mucosa1.27887560
53MP0004885_abnormal_endolymph1.25765085
54MP0003786_premature_aging1.22815917
55MP0002736_abnormal_nociception_after1.22645194
56MP0001986_abnormal_taste_sensitivity1.21695240
57MP0002160_abnormal_reproductive_system1.21635818
58MP0002693_abnormal_pancreas_physiology1.19084195
59MP0002452_abnormal_antigen_presenting1.16171466
60MP0001764_abnormal_homeostasis1.16026715
61MP0002095_abnormal_skin_pigmentation1.15873249
62MP0010155_abnormal_intestine_physiology1.11580613
63MP0005636_abnormal_mineral_homeostasis1.06825365
64MP0008058_abnormal_DNA_repair1.04377577
65MP0001845_abnormal_inflammatory_respons1.04220139
66MP0009764_decreased_sensitivity_to1.03656427
67MP0006082_CNS_inflammation1.02612202
68MP0000716_abnormal_immune_system1.02448839
69MP0006276_abnormal_autonomic_nervous1.01413927
70MP0003186_abnormal_redox_activity1.00695002
71MP0004043_abnormal_pH_regulation0.99629394
72MP0002398_abnormal_bone_marrow0.99332867
73MP0008995_early_reproductive_senescence0.99106042
74MP0003283_abnormal_digestive_organ0.99097508
75MP0005410_abnormal_fertilization0.98206685
76MP0003252_abnormal_bile_duct0.95987978
77MP0000689_abnormal_spleen_morphology0.95356903
78MP0005174_abnormal_tail_pigmentation0.94961831
79MP0001501_abnormal_sleep_pattern0.94426773
80MP0005360_urolithiasis0.94355341
81MP0003724_increased_susceptibility_to0.93897391
82MP0009745_abnormal_behavioral_response0.93332551
83MP0005332_abnormal_amino_acid0.92453470
84MP0010386_abnormal_urinary_bladder0.92162405
85MP0002234_abnormal_pharynx_morphology0.87582257
86MP0003880_abnormal_central_pattern0.86512309
87MP0008469_abnormal_protein_level0.85838934
88MP0001984_abnormal_olfaction0.85718373
89MP0003806_abnormal_nucleotide_metabolis0.84498988
90MP0002405_respiratory_system_inflammati0.83724817
91MP0000703_abnormal_thymus_morphology0.81858024
92MP0002272_abnormal_nervous_system0.81246624
93MP0001765_abnormal_ion_homeostasis0.80771307
94MP0000230_abnormal_systemic_arterial0.79410096
95MP0005085_abnormal_gallbladder_physiolo0.78417223
96MP0002429_abnormal_blood_cell0.78352461
97MP0002722_abnormal_immune_system0.78290179
98MP0001485_abnormal_pinna_reflex0.77339908
99MP0009643_abnormal_urine_homeostasis0.77227239
100MP0005377_hearing/vestibular/ear_phenot0.76769627

Predicted human phenotypes

RankGene SetZ-score
1Mitochondrial inheritance (HP:0001427)4.22230879
2Increased hepatocellular lipid droplets (HP:0006565)4.00355853
3Acute necrotizing encephalopathy (HP:0006965)3.97256785
4Increased CSF lactate (HP:0002490)3.85980121
5Lipid accumulation in hepatocytes (HP:0006561)3.72222026
6Abnormal mitochondria in muscle tissue (HP:0008316)3.69602594
7IgG deficiency (HP:0004315)3.69343423
8Hepatocellular necrosis (HP:0001404)3.64251069
93-Methylglutaconic aciduria (HP:0003535)3.58868910
10Renal Fanconi syndrome (HP:0001994)3.51559934
11Increased intramyocellular lipid droplets (HP:0012240)3.47676881
12Progressive macrocephaly (HP:0004481)3.47508220
13Acute encephalopathy (HP:0006846)3.36419923
14Aplastic anemia (HP:0001915)3.34977226
15Hepatic necrosis (HP:0002605)3.34765049
16Congenital stationary night blindness (HP:0007642)3.30809775
17Absent rod-and cone-mediated responses on ERG (HP:0007688)3.10389272
18Hypoproteinemia (HP:0003075)2.99911531
19Abnormal rod and cone electroretinograms (HP:0008323)2.99193311
20Methylmalonic acidemia (HP:0002912)2.98716653
21Pancreatic cysts (HP:0001737)2.96086732
22Increased muscle lipid content (HP:0009058)2.90564618
23Decreased activity of mitochondrial respiratory chain (HP:0008972)2.90147468
24Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.90147468
25Severe combined immunodeficiency (HP:0004430)2.87286932
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.78648101
27Elevated erythrocyte sedimentation rate (HP:0003565)2.75470688
28Increased serum lactate (HP:0002151)2.72620350
29Exertional dyspnea (HP:0002875)2.72301929
30Stomatitis (HP:0010280)2.69873330
31Cerebral edema (HP:0002181)2.66577239
32Thyroiditis (HP:0100646)2.66200688
33Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.62226223
34Methylmalonic aciduria (HP:0012120)2.62192073
35Abolished electroretinogram (ERG) (HP:0000550)2.61731307
36Attenuation of retinal blood vessels (HP:0007843)2.54399039
37Decreased central vision (HP:0007663)2.52801261
38Lactic acidosis (HP:0003128)2.52591829
39Molar tooth sign on MRI (HP:0002419)2.50446426
40Abnormality of midbrain morphology (HP:0002418)2.50446426
41Pancreatic fibrosis (HP:0100732)2.48631572
42Abnormality of B cell number (HP:0010975)2.47453365
43True hermaphroditism (HP:0010459)2.45295609
44Optic disc pallor (HP:0000543)2.37996003
45B lymphocytopenia (HP:0010976)2.36746069
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33664929
47T lymphocytopenia (HP:0005403)2.29900480
48Aplasia/hypoplasia of the uterus (HP:0008684)2.26063844
49Abnormality of T cell number (HP:0011839)2.25065923
50Glycosuria (HP:0003076)2.23980157
51Abnormality of urine glucose concentration (HP:0011016)2.23980157
52Type II lissencephaly (HP:0007260)2.23587320
53Abnormality of renal resorption (HP:0011038)2.21527341
54Abnormality of T cells (HP:0002843)2.19803403
55Ketoacidosis (HP:0001993)2.19331823
56Ketosis (HP:0001946)2.18621813
57Abnormality of the renal cortex (HP:0011035)2.18454521
58Lethargy (HP:0001254)2.17209738
59Dicarboxylic aciduria (HP:0003215)2.16667998
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.16667998
61Autoimmune hemolytic anemia (HP:0001890)2.13371082
62Respiratory failure (HP:0002878)2.10930892
63Nephronophthisis (HP:0000090)2.10907554
64Congenital, generalized hypertrichosis (HP:0004540)2.10626596
65Respiratory difficulties (HP:0002880)2.09612462
66Renal cortical cysts (HP:0000803)2.09410857
67Hypothermia (HP:0002045)2.05721690
68Combined immunodeficiency (HP:0005387)2.03880786
69Pendular nystagmus (HP:0012043)2.02854358
70Abnormality of vitamin B metabolism (HP:0004340)2.02593744
71Macrocytic anemia (HP:0001972)2.01792177
72Abnormality of eosinophils (HP:0001879)1.98979220
73Abnormality of the prostate (HP:0008775)1.98782894
74Panhypogammaglobulinemia (HP:0003139)1.98517740
75Abnormal number of erythroid precursors (HP:0012131)1.98108616
76Abnormality of cells of the erythroid lineage (HP:0012130)1.97995805
77Absent thumb (HP:0009777)1.96790657
78Pancytopenia (HP:0001876)1.94900111
79Exercise intolerance (HP:0003546)1.94370197
80Abnormality of alanine metabolism (HP:0010916)1.93676555
81Hyperalaninemia (HP:0003348)1.93676555
82Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93676555
83Type 2 muscle fiber atrophy (HP:0003554)1.92566217
84Hyperphosphaturia (HP:0003109)1.91576655
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.87634494
86Keratoconus (HP:0000563)1.87032944
87Increased corneal curvature (HP:0100692)1.87032944
88Constricted visual fields (HP:0001133)1.86222249
89CNS demyelination (HP:0007305)1.85214805
90Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81694196
91Increased IgM level (HP:0003496)1.81636288
92Type I transferrin isoform profile (HP:0003642)1.78756023
93Hypoplasia of the uterus (HP:0000013)1.77908326
94Polydipsia (HP:0001959)1.75970581
95Abnormal drinking behavior (HP:0030082)1.75970581
96IgM deficiency (HP:0002850)1.75008262
97Hyperglycinemia (HP:0002154)1.74777894
98Abnormality of the renal medulla (HP:0100957)1.71517293
99Abnormality of T cell physiology (HP:0011840)1.70563083
100Eosinophilia (HP:0001880)1.68914572

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.19900440
2FRK3.08892950
3KDR2.88052149
4ZAK2.77930462
5ADRBK22.66920860
6MAP4K22.64827954
7TAOK32.61040346
8TLK12.58388345
9VRK22.53392688
10NUAK12.38227923
11BCKDK2.33374889
12GRK12.30996880
13TESK21.99175994
14MAP4K11.88088213
15ITK1.79773493
16VRK11.75508336
17STK161.75359331
18BMPR1B1.65011706
19FES1.55295128
20MST41.54574320
21TEC1.42474868
22WNK41.38743076
23PINK11.38037899
24CDK191.36479161
25WNK31.30819769
26PASK1.30135504
27MAP2K61.26859867
28EIF2AK31.26718976
29IKBKB1.20004382
30MAP3K121.19948110
31TIE11.19154299
32GRK61.19050771
33SYK1.14599619
34SCYL21.14160766
35OXSR11.09726866
36KIT1.09032595
37IKBKE1.09018984
38LIMK11.06623660
39PRKCQ1.00945617
40INSRR1.00548824
41LCK0.95839797
42BUB10.91864194
43MUSK0.90078502
44PHKG20.89325378
45PHKG10.89325378
46ADRBK10.85957313
47NME10.84535138
48ACVR1B0.82802680
49CSNK1G30.82602633
50TNK20.81152282
51BMPR20.79454498
52DAPK10.77090123
53RPS6KA50.76705928
54CSNK1G10.76184208
55BTK0.73681659
56TRIM280.73087429
57LYN0.72354885
58STK390.71070928
59GRK70.71008582
60CSF1R0.70138517
61CAMKK20.69738535
62CSNK1G20.69244278
63MYLK0.68490830
64PIK3CG0.64603405
65DYRK20.63642649
66MAPK130.63200132
67OBSCN0.61797138
68PLK30.61469532
69TBK10.60153417
70DAPK20.59762707
71PRKCE0.59476284
72JAK30.58310271
73PIM10.56868148
74ERBB30.56492024
75PIK3CA0.54211032
76PLK20.52575202
77PRKCG0.51208898
78TAF10.49969619
79PRKCA0.49870050
80GRK50.49097656
81MAPKAPK30.48120773
82FLT30.45827270
83PRKACA0.45583096
84ZAP700.45287036
85IGF1R0.45181476
86CDK80.43777282
87CSNK2A20.41741488
88CSNK2A10.39091344
89CSNK1A10.38939535
90CSNK1A1L0.38254813
91ILK0.38024820
92NME20.37863097
93RPS6KA40.37395230
94PRKCI0.35485489
95PBK0.35314426
96MATK0.35154241
97CAMK10.34953885
98MAPKAPK50.34868647
99DAPK30.34694856
100TGFBR10.34651469

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.86281975
2Proteasome_Homo sapiens_hsa030503.69265139
3Ribosome_Homo sapiens_hsa030103.60651896
4Parkinsons disease_Homo sapiens_hsa050123.11454079
5Primary immunodeficiency_Homo sapiens_hsa053403.08338617
6Allograft rejection_Homo sapiens_hsa053302.40390423
7Autoimmune thyroid disease_Homo sapiens_hsa053202.39091972
8Asthma_Homo sapiens_hsa053102.28330026
9Type I diabetes mellitus_Homo sapiens_hsa049402.27285681
10Protein export_Homo sapiens_hsa030602.26946803
11Graft-versus-host disease_Homo sapiens_hsa053322.23621646
12RNA polymerase_Homo sapiens_hsa030202.22503830
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.11266882
14Alzheimers disease_Homo sapiens_hsa050102.04651900
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.01241722
16Huntingtons disease_Homo sapiens_hsa050161.89483699
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.79568985
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71047460
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65931540
20Maturity onset diabetes of the young_Homo sapiens_hsa049501.63828396
21Cardiac muscle contraction_Homo sapiens_hsa042601.59278245
22Antigen processing and presentation_Homo sapiens_hsa046121.58452768
23Phototransduction_Homo sapiens_hsa047441.57472144
24Linoleic acid metabolism_Homo sapiens_hsa005911.48692553
25RNA degradation_Homo sapiens_hsa030181.41247722
26Homologous recombination_Homo sapiens_hsa034401.36201018
27Rheumatoid arthritis_Homo sapiens_hsa053231.35330172
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.32066450
29Hematopoietic cell lineage_Homo sapiens_hsa046401.30913435
30Sulfur metabolism_Homo sapiens_hsa009201.27043023
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25682200
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24552789
33Peroxisome_Homo sapiens_hsa041461.22822934
34Nitrogen metabolism_Homo sapiens_hsa009101.22062278
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.19006761
36Caffeine metabolism_Homo sapiens_hsa002321.16821163
37Basal transcription factors_Homo sapiens_hsa030221.13513576
38Butanoate metabolism_Homo sapiens_hsa006501.13019241
39Pyrimidine metabolism_Homo sapiens_hsa002401.11240972
40One carbon pool by folate_Homo sapiens_hsa006701.11140799
41Tryptophan metabolism_Homo sapiens_hsa003801.06391541
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.05380330
43Propanoate metabolism_Homo sapiens_hsa006401.04139030
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97871461
45Collecting duct acid secretion_Homo sapiens_hsa049660.96328818
46Selenocompound metabolism_Homo sapiens_hsa004500.94468779
47Purine metabolism_Homo sapiens_hsa002300.91458177
48Arachidonic acid metabolism_Homo sapiens_hsa005900.88598851
49Fanconi anemia pathway_Homo sapiens_hsa034600.87540092
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87434348
51Nucleotide excision repair_Homo sapiens_hsa034200.85335644
52Retinol metabolism_Homo sapiens_hsa008300.81287673
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.80040715
54Chemical carcinogenesis_Homo sapiens_hsa052040.79313596
55Olfactory transduction_Homo sapiens_hsa047400.76033960
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.75674753
57T cell receptor signaling pathway_Homo sapiens_hsa046600.75505838
58Ether lipid metabolism_Homo sapiens_hsa005650.75195483
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74354657
60Regulation of autophagy_Homo sapiens_hsa041400.71272961
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.69332904
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67820891
63Mismatch repair_Homo sapiens_hsa034300.66834962
64Metabolic pathways_Homo sapiens_hsa011000.66744198
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64582405
66RNA transport_Homo sapiens_hsa030130.63906608
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61707677
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.59992390
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58530868
70Spliceosome_Homo sapiens_hsa030400.58276969
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57072011
72Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56282375
73Sulfur relay system_Homo sapiens_hsa041220.55957534
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.55102731
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53774631
76Systemic lupus erythematosus_Homo sapiens_hsa053220.53431763
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52356818
78Base excision repair_Homo sapiens_hsa034100.48623680
79DNA replication_Homo sapiens_hsa030300.48307158
80Viral myocarditis_Homo sapiens_hsa054160.46475156
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.46289698
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46200565
83Fatty acid elongation_Homo sapiens_hsa000620.45352178
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.44864463
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41627224
86Taste transduction_Homo sapiens_hsa047420.41321789
87Fat digestion and absorption_Homo sapiens_hsa049750.40583665
88Glutathione metabolism_Homo sapiens_hsa004800.40256222
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.35642201
90Staphylococcus aureus infection_Homo sapiens_hsa051500.33808743
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31758149
92Measles_Homo sapiens_hsa051620.30919127
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30868264
94Vitamin digestion and absorption_Homo sapiens_hsa049770.29192401
95beta-Alanine metabolism_Homo sapiens_hsa004100.29037778
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28360474
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27290782
98ABC transporters_Homo sapiens_hsa020100.26512300
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25738644
100Fatty acid degradation_Homo sapiens_hsa000710.23975438

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