ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.31602181
2	proteasome assembly (GO:0043248)	5.01779331
3	ATP synthesis coupled proton transport (GO:0015986)	4.94079772
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.94079772
5	maturation of SSU-rRNA (GO:0030490)	4.40231756
6	water-soluble vitamin biosynthetic process (GO:0042364)	4.27290555
7	ribosomal small subunit assembly (GO:0000028)	4.20507623
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.14988895
9	S-adenosylmethionine metabolic process (GO:0046500)	4.10386812
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.07748174
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.05877421
12	chaperone-mediated protein transport (GO:0072321)	3.89495742
13	termination of RNA polymerase III transcription (GO:0006386)	3.84886003
14	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.84886003
15	protein complex biogenesis (GO:0070271)	3.79285908
16	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.74577741
17	NADH dehydrogenase complex assembly (GO:0010257)	3.74577741
18	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.74577741
19	protein neddylation (GO:0045116)	3.72362978
20	L-fucose metabolic process (GO:0042354)	3.70143716
21	L-fucose catabolic process (GO:0042355)	3.70143716
22	fucose catabolic process (GO:0019317)	3.70143716
23	respiratory chain complex IV assembly (GO:0008535)	3.69675060
24	ribosomal large subunit biogenesis (GO:0042273)	3.62766115
25	electron transport chain (GO:0022900)	3.58002770
26	mitochondrial respiratory chain complex assembly (GO:0033108)	3.55204696
27	respiratory electron transport chain (GO:0022904)	3.54978823
28	protein-cofactor linkage (GO:0018065)	3.49355302
29	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.38488157
30	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.38488157
31	protein deneddylation (GO:0000338)	3.31324068
32	cullin deneddylation (GO:0010388)	3.26698947
33	mannosylation (GO:0097502)	3.26448300
34	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.22657469
35	GTP biosynthetic process (GO:0006183)	3.18756306
36	cytochrome complex assembly (GO:0017004)	3.17355179
37	preassembly of GPI anchor in ER membrane (GO:0016254)	3.14956183
38	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.14043045
39	peptidyl-histidine modification (GO:0018202)	3.13333375
40	ATP biosynthetic process (GO:0006754)	3.12554647
41	tRNA processing (GO:0008033)	3.10402109
42	GPI anchor metabolic process (GO:0006505)	3.05513381
43	viral transcription (GO:0019083)	3.05499203
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.04791912
45	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.01773451
46	hydrogen ion transmembrane transport (GO:1902600)	3.01051392
47	GPI anchor biosynthetic process (GO:0006506)	3.00805579
48	translational termination (GO:0006415)	3.00591481
49	intracellular protein transmembrane import (GO:0044743)	2.97031398
50	rRNA modification (GO:0000154)	2.95339784
51	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.93330038
52	indolalkylamine catabolic process (GO:0046218)	2.92468309
53	tryptophan catabolic process (GO:0006569)	2.92468309
54	indole-containing compound catabolic process (GO:0042436)	2.92468309
55	translation (GO:0006412)	2.92024182
56	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.89655029
57	translational elongation (GO:0006414)	2.89194590
58	regulation of cellular amino acid metabolic process (GO:0006521)	2.87418739
59	cotranslational protein targeting to membrane (GO:0006613)	2.86393517
60	protein targeting to ER (GO:0045047)	2.85092606
61	regulation of immunoglobulin secretion (GO:0051023)	2.84796990
62	cellular component biogenesis (GO:0044085)	2.84254137
63	UTP metabolic process (GO:0046051)	2.83810367
64	tryptophan metabolic process (GO:0006568)	2.82867097
65	proton transport (GO:0015992)	2.81013258
66	hydrogen transport (GO:0006818)	2.79785878
67	aldehyde catabolic process (GO:0046185)	2.77104863
68	protein localization to endoplasmic reticulum (GO:0070972)	2.76659049
69	ubiquinone biosynthetic process (GO:0006744)	2.72950588
70	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.71865148
71	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.71712318
72	indolalkylamine metabolic process (GO:0006586)	2.71469795
73	protein targeting to mitochondrion (GO:0006626)	2.71335861
74	platelet dense granule organization (GO:0060155)	2.70985247
75	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.69199411
76	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.68965168
77	piRNA metabolic process (GO:0034587)	2.67060943
78	kynurenine metabolic process (GO:0070189)	2.66894486
79	purine deoxyribonucleotide catabolic process (GO:0009155)	2.65916414
80	ribosomal small subunit biogenesis (GO:0042274)	2.64244327
81	base-excision repair, AP site formation (GO:0006285)	2.63340351
82	cytidine metabolic process (GO:0046087)	2.63298228
83	cytidine catabolic process (GO:0006216)	2.63298228
84	cytidine deamination (GO:0009972)	2.63298228
85	rRNA processing (GO:0006364)	2.63254558
86	branched-chain amino acid catabolic process (GO:0009083)	2.63227343
87	positive regulation of prostaglandin secretion (GO:0032308)	2.62639762
88	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.62422343
89	rRNA metabolic process (GO:0016072)	2.61823519
90	tRNA metabolic process (GO:0006399)	2.61822501
91	UTP biosynthetic process (GO:0006228)	2.61647734
92	behavioral response to nicotine (GO:0035095)	2.58568971
93	metallo-sulfur cluster assembly (GO:0031163)	2.58416640
94	iron-sulfur cluster assembly (GO:0016226)	2.58416640
95	GMP metabolic process (GO:0046037)	2.58380481
96	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.58118283
97	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.58118283
98	isotype switching (GO:0045190)	2.58118283
99	pseudouridine synthesis (GO:0001522)	2.56496904
100	establishment of protein localization to mitochondrion (GO:0072655)	2.56141926

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.40194014
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.12579895
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.77710226
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.59124114
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.23974250
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.18813939
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.12926955
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.92724209
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.91614902
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.89010865
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.80370666
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.62451507
13	VDR_22108803_ChIP-Seq_LS180_Human	2.50108603
14	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.35042617
15	FOXP3_21729870_ChIP-Seq_TREG_Human	2.27344458
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.11016576
17	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.09255276
18	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08680010
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.00852467
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99417232
21	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.97311804
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.95088588
23	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.82827387
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.82463602
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78773129
26	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.73548431
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.70929876
28	MYC_18940864_ChIP-ChIP_HL60_Human	1.67174390
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.65136955
30	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.64399419
31	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.58408235
32	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.54174252
33	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.53402176
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.49958411
35	TTF2_22483619_ChIP-Seq_HELA_Human	1.49674622
36	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48924301
37	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.47625815
38	AR_20517297_ChIP-Seq_VCAP_Human	1.46853647
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.45676469
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.45676469
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.44634650
42	DCP1A_22483619_ChIP-Seq_HELA_Human	1.44629239
43	EWS_26573619_Chip-Seq_HEK293_Human	1.40887182
44	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.38183032
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.36890103
46	GATA3_26560356_Chip-Seq_TH2_Human	1.32639859
47	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.31126009
48	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.29815583
49	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.29764426
50	FUS_26573619_Chip-Seq_HEK293_Human	1.29447289
51	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.29074168
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.28977312
53	NANOG_19829295_ChIP-Seq_ESCs_Human	1.26268965
54	SOX2_19829295_ChIP-Seq_ESCs_Human	1.26268965
55	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.24453756
56	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.23374900
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23186823
58	NCOR_22424771_ChIP-Seq_293T_Human	1.17119490
59	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12293360
60	ERG_20517297_ChIP-Seq_VCAP_Human	1.12096949
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.11689220
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.11227798
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09930993
64	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.09738104
65	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.09593587
66	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.09346572
67	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.08013580
68	P300_19829295_ChIP-Seq_ESCs_Human	1.06836537
69	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.06669401
70	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.04404538
71	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03962083
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.03317479
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.03269916
74	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.02820822
75	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.02629461
76	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.01761078
77	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01333963
78	ER_23166858_ChIP-Seq_MCF-7_Human	1.00475442
79	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.00226395
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.00080292
81	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.99657424
82	NANOG_20526341_ChIP-Seq_ESCs_Human	0.99073607
83	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98698169
84	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.98198723
85	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.97742193
86	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.95391524
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.95343566
88	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.95324536
89	RBPJ_21746931_ChIP-Seq_IB4_Human	0.95150785
90	ERA_21632823_ChIP-Seq_H3396_Human	0.94397385
91	P53_21459846_ChIP-Seq_SAOS-2_Human	0.94015002
92	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.93848234
93	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.93479397
94	PHF8_20622853_ChIP-Seq_HELA_Human	0.92468498
95	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.92235116
96	TAF15_26573619_Chip-Seq_HEK293_Human	0.92057233
97	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91812023
98	XRN2_22483619_ChIP-Seq_HELA_Human	0.91630379
99	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.91218980
100	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.90908251

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.55098211
2	MP0008875_abnormal_xenobiotic_pharmacok	2.84625721
3	MP0003195_calcinosis	2.73983468
4	MP0001986_abnormal_taste_sensitivity	2.62937692
5	MP0004147_increased_porphyrin_level	2.49333255
6	MP0005671_abnormal_response_to	2.43521091
7	MP0006072_abnormal_retinal_apoptosis	2.41349027
8	MP0002876_abnormal_thyroid_physiology	2.39616752
9	MP0005377_hearing/vestibular/ear_phenot	2.39423035
10	MP0003878_abnormal_ear_physiology	2.39423035
11	MP0005360_urolithiasis	2.37009486
12	MP0008877_abnormal_DNA_methylation	2.21901350
13	MP0004885_abnormal_endolymph	2.17504403
14	MP0005646_abnormal_pituitary_gland	2.08914430
15	MP0002102_abnormal_ear_morphology	2.08722367
16	MP0002138_abnormal_hepatobiliary_system	2.06838509
17	MP0001835_abnormal_antigen_presentation	2.05821538
18	MP0001968_abnormal_touch/_nociception	1.97848971
19	MP0008872_abnormal_physiological_respon	1.95875317
20	MP0002736_abnormal_nociception_after	1.86698768
21	MP0006036_abnormal_mitochondrial_physio	1.85449034
22	MP0002837_dystrophic_cardiac_calcinosis	1.80081654
23	MP0002163_abnormal_gland_morphology	1.80060529
24	MP0005084_abnormal_gallbladder_morpholo	1.74350836
25	MP0003786_premature_aging	1.72172894
26	MP0005551_abnormal_eye_electrophysiolog	1.64623362
27	MP0003724_increased_susceptibility_to	1.59379139
28	MP0008058_abnormal_DNA_repair	1.53678270
29	MP0004145_abnormal_muscle_electrophysio	1.53453893
30	MP0001501_abnormal_sleep_pattern	1.49686141
31	MP0006292_abnormal_olfactory_placode	1.48870353
32	MP0004142_abnormal_muscle_tone	1.47700470
33	MP0002277_abnormal_respiratory_mucosa	1.45871862
34	MP0005645_abnormal_hypothalamus_physiol	1.43348080
35	MP0005379_endocrine/exocrine_gland_phen	1.42157785
36	MP0005253_abnormal_eye_physiology	1.40808279
37	MP0009785_altered_susceptibility_to	1.38020039
38	MP0003186_abnormal_redox_activity	1.37740158
39	MP0002148_abnormal_hypersensitivity_rea	1.37581794
40	MP0009379_abnormal_foot_pigmentation	1.37490893
41	MP0000685_abnormal_immune_system	1.35348580
42	MP0005636_abnormal_mineral_homeostasis	1.35163727
43	MP0005332_abnormal_amino_acid	1.33871411
44	MP0003718_maternal_effect	1.31170167
45	MP0001764_abnormal_homeostasis	1.29932200
46	MP0001800_abnormal_humoral_immune	1.29084642
47	MP0003866_abnormal_defecation	1.21522429
48	MP0006276_abnormal_autonomic_nervous	1.20562672
49	MP0002909_abnormal_adrenal_gland	1.19145996
50	MP0000372_irregular_coat_pigmentation	1.17842560
51	MP0004043_abnormal_pH_regulation	1.17612223
52	MP0006035_abnormal_mitochondrial_morpho	1.16697275
53	MP0003646_muscle_fatigue	1.15335212
54	MP0001485_abnormal_pinna_reflex	1.15114157
55	MP0005000_abnormal_immune_tolerance	1.09478760
56	MP0001905_abnormal_dopamine_level	1.07545562
57	MP0008995_early_reproductive_senescence	1.07440785
58	MP0002723_abnormal_immune_serum	1.07036632
59	MP0010329_abnormal_lipoprotein_level	1.05178308
60	MP0005075_abnormal_melanosome_morpholog	1.03366742
61	MP0002234_abnormal_pharynx_morphology	1.03143585
62	MP0003787_abnormal_imprinting	1.02281974
63	MP0001984_abnormal_olfaction	1.01973128
64	MP0002095_abnormal_skin_pigmentation	1.01964288
65	MP0003880_abnormal_central_pattern	1.01378141
66	MP0003693_abnormal_embryo_hatching	0.99212098
67	MP0003011_delayed_dark_adaptation	0.99195958
68	MP0000631_abnormal_neuroendocrine_gland	0.98969709
69	MP0002693_abnormal_pancreas_physiology	0.98392659
70	MP0005389_reproductive_system_phenotype	0.97982498
71	MP0008775_abnormal_heart_ventricle	0.96293901
72	MP0005085_abnormal_gallbladder_physiolo	0.96053613
73	MP0000230_abnormal_systemic_arterial	0.93553471
74	MP0002139_abnormal_hepatobiliary_system	0.92876580
75	MP0009745_abnormal_behavioral_response	0.91788421
76	MP0002452_abnormal_antigen_presenting	0.89667446
77	MP0001756_abnormal_urination	0.88596685
78	MP0005365_abnormal_bile_salt	0.88405929
79	MP0009764_decreased_sensitivity_to	0.88297229
80	MP0002272_abnormal_nervous_system	0.86853194
81	MP0001819_abnormal_immune_cell	0.86803902
82	MP0001919_abnormal_reproductive_system	0.86274277
83	MP0009643_abnormal_urine_homeostasis	0.85622343
84	MP0005410_abnormal_fertilization	0.85192354
85	MP0002420_abnormal_adaptive_immunity	0.83672719
86	MP0001845_abnormal_inflammatory_respons	0.81029996
87	MP0005387_immune_system_phenotype	0.80811613
88	MP0001790_abnormal_immune_system	0.80811613
89	MP0003283_abnormal_digestive_organ	0.79278635
90	MP0000015_abnormal_ear_pigmentation	0.78131543
91	MP0001529_abnormal_vocalization	0.77981595
92	MP0003436_decreased_susceptibility_to	0.77882302
93	MP0008789_abnormal_olfactory_epithelium	0.75607011
94	MP0004019_abnormal_vitamin_homeostasis	0.74345621
95	MP0001502_abnormal_circadian_rhythm	0.73274555
96	MP0002006_tumorigenesis	0.73049081
97	MP0001765_abnormal_ion_homeostasis	0.72147711
98	MP0002938_white_spotting	0.71510665
99	MP0009333_abnormal_splenocyte_physiolog	0.71074049
100	MP0002160_abnormal_reproductive_system	0.70273902

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.76654274
2	Acute encephalopathy (HP:0006846)	4.32817297
3	Mitochondrial inheritance (HP:0001427)	4.25330633
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.22730379
5	Increased CSF lactate (HP:0002490)	4.11457832
6	Progressive macrocephaly (HP:0004481)	4.07138642
7	Hepatocellular necrosis (HP:0001404)	3.95230866
8	Hepatic necrosis (HP:0002605)	3.82654152
9	Pancreatic cysts (HP:0001737)	3.49679090
10	3-Methylglutaconic aciduria (HP:0003535)	3.30249007
11	Stomatitis (HP:0010280)	3.28321769
12	Cerebral edema (HP:0002181)	3.26921390
13	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.22658045
14	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.22658045
15	Increased serum lactate (HP:0002151)	3.13010521
16	Increased hepatocellular lipid droplets (HP:0006565)	3.10226068
17	Pancreatic fibrosis (HP:0100732)	2.98171357
18	Renal cortical cysts (HP:0000803)	2.93740459
19	Lipid accumulation in hepatocytes (HP:0006561)	2.90955363
20	Lactic acidosis (HP:0003128)	2.86485603
21	Congenital stationary night blindness (HP:0007642)	2.84695096
22	IgG deficiency (HP:0004315)	2.80661819
23	Renal Fanconi syndrome (HP:0001994)	2.79625561
24	Molar tooth sign on MRI (HP:0002419)	2.78080798
25	Abnormality of midbrain morphology (HP:0002418)	2.78080798
26	Increased intramyocellular lipid droplets (HP:0012240)	2.65536033
27	Abnormality of the renal cortex (HP:0011035)	2.64213939
28	Lethargy (HP:0001254)	2.62359583
29	True hermaphroditism (HP:0010459)	2.62250470
30	Generalized aminoaciduria (HP:0002909)	2.57444909
31	Colon cancer (HP:0003003)	2.56602490
32	Nephronophthisis (HP:0000090)	2.52903859
33	Methylmalonic acidemia (HP:0002912)	2.51289177
34	Hypothermia (HP:0002045)	2.50938885
35	Optic disc pallor (HP:0000543)	2.50069808
36	Abolished electroretinogram (ERG) (HP:0000550)	2.44108679
37	Respiratory failure (HP:0002878)	2.42998865
38	Abnormal rod and cone electroretinograms (HP:0008323)	2.36669464
39	Methylmalonic aciduria (HP:0012120)	2.36072600
40	Abnormal number of erythroid precursors (HP:0012131)	2.35549685
41	Abnormality of cells of the erythroid lineage (HP:0012130)	2.30273663
42	Aplasia/hypoplasia of the uterus (HP:0008684)	2.29895344
43	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.29353228
44	Type II lissencephaly (HP:0007260)	2.29058139
45	Increased muscle lipid content (HP:0009058)	2.21664930
46	Exertional dyspnea (HP:0002875)	2.21626963
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.19238071
48	Attenuation of retinal blood vessels (HP:0007843)	2.18417390
49	Stomach cancer (HP:0012126)	2.15266057
50	Type I transferrin isoform profile (HP:0003642)	2.14328460
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.14031247
52	Medial flaring of the eyebrow (HP:0010747)	2.11842018
53	Chronic hepatic failure (HP:0100626)	2.10449495
54	Exercise intolerance (HP:0003546)	2.09355160
55	Glycosuria (HP:0003076)	2.09293692
56	Abnormality of urine glucose concentration (HP:0011016)	2.09293692
57	Leukodystrophy (HP:0002415)	2.08176905
58	Elevated erythrocyte sedimentation rate (HP:0003565)	2.05808862
59	Dicarboxylic aciduria (HP:0003215)	2.05052523
60	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.05052523
61	Polydipsia (HP:0001959)	2.03834101
62	Abnormal drinking behavior (HP:0030082)	2.03834101
63	Progressive microcephaly (HP:0000253)	2.03492941
64	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.03328687
65	Ketosis (HP:0001946)	2.02415596
66	Severe combined immunodeficiency (HP:0004430)	2.01356767
67	Abnormality of the renal medulla (HP:0100957)	2.01118264
68	Hyperglycinemia (HP:0002154)	2.00404561
69	Macrocytic anemia (HP:0001972)	1.97282564
70	Severe muscular hypotonia (HP:0006829)	1.96884207
71	Hyperglycinuria (HP:0003108)	1.96790626
72	Reticulocytopenia (HP:0001896)	1.95283489
73	Decreased central vision (HP:0007663)	1.95017137
74	Ketoacidosis (HP:0001993)	1.94756055
75	Pendular nystagmus (HP:0012043)	1.94701220
76	Hyperalaninemia (HP:0003348)	1.94599470
77	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.94599470
78	Abnormality of alanine metabolism (HP:0010916)	1.94599470
79	Pancytopenia (HP:0001876)	1.94073503
80	Bile duct proliferation (HP:0001408)	1.93823795
81	Abnormal biliary tract physiology (HP:0012439)	1.93823795
82	Hypomagnesemia (HP:0002917)	1.91130007
83	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.90929227
84	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.89046672
85	Thyroid-stimulating hormone excess (HP:0002925)	1.86329228
86	CNS demyelination (HP:0007305)	1.84691664
87	Abnormality of T cell physiology (HP:0011840)	1.83577543
88	Type 2 muscle fiber atrophy (HP:0003554)	1.81787070
89	Abnormality of the prostate (HP:0008775)	1.81114184
90	Abnormal hemoglobin (HP:0011902)	1.79284408
91	Tongue fasciculations (HP:0001308)	1.75784790
92	Abnormality of glycine metabolism (HP:0010895)	1.73856669
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.73856669
94	Cystic liver disease (HP:0006706)	1.73643899
95	Constricted visual fields (HP:0001133)	1.73247775
96	Hypoplasia of the uterus (HP:0000013)	1.70984159
97	Panhypogammaglobulinemia (HP:0003139)	1.70798434
98	Absent thumb (HP:0009777)	1.70525668
99	Testicular atrophy (HP:0000029)	1.69704272
100	Hypoproteinemia (HP:0003075)	1.69376509

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.43945618
2	TLK1	3.33204906
3	TXK	3.24721974
4	NUAK1	3.04343902
5	ZAK	3.01562380
6	FRK	2.76318014
7	TRIM28	2.33662427
8	ADRBK2	2.33373721
9	GRK1	2.25393698
10	BCKDK	2.11903868
11	BMPR1B	2.03366000
12	MST4	2.01436958
13	MAP4K2	1.95065979
14	VRK2	1.80761924
15	EIF2AK3	1.78480283
16	CDK19	1.77044841
17	ITK	1.70176550
18	WNK4	1.65506822
19	WNK3	1.57210807
20	STK16	1.54234686
21	TEC	1.53278703
22	BUB1	1.50907496
23	MAP2K6	1.50247847
24	TSSK6	1.49990480
25	PINK1	1.49653734
26	SRPK1	1.48137489
27	MAP4K1	1.46689217
28	OXSR1	1.41617112
29	IKBKB	1.40635383
30	NME2	1.40456309
31	MAP3K12	1.39269601
32	VRK1	1.28015248
33	PHKG2	1.23500796
34	PHKG1	1.23500796
35	EIF2AK1	1.23280006
36	PDK2	1.19174952
37	DYRK2	1.13748619
38	PASK	1.08365104
39	TIE1	1.07746890
40	NME1	1.05505392
41	PLK3	0.98945506
42	KDR	0.97413393
43	STK39	0.93004409
44	INSRR	0.88479243
45	LIMK1	0.88369785
46	RPS6KA5	0.88123484
47	SYK	0.87943110
48	MYLK	0.81970257
49	GRK6	0.81741325
50	EIF2AK2	0.78760256
51	DAPK1	0.76105222
52	CSNK1G3	0.75103887
53	BMPR2	0.74214148
54	RPS6KA4	0.73905125
55	FLT3	0.71665702
56	NEK1	0.70085765
57	BTK	0.69817755
58	MAP2K2	0.67966826
59	PBK	0.67802037
60	MKNK1	0.67668175
61	CSF1R	0.67618764
62	MKNK2	0.67544387
63	TGFBR1	0.66716430
64	CSNK1G1	0.66094449
65	PRKCQ	0.63473552
66	ABL2	0.61945269
67	ADRBK1	0.59277251
68	GRK7	0.58488900
69	PLK4	0.58378927
70	DAPK2	0.57684860
71	PLK2	0.57415336
72	TRPM7	0.56670956
73	ERBB3	0.55580061
74	LYN	0.55376395
75	CSNK1G2	0.53750026
76	FES	0.50556630
77	TNIK	0.50122195
78	PRKCG	0.49414555
79	LCK	0.48809615
80	PRKCE	0.48694586
81	IGF1R	0.46776382
82	CSNK2A1	0.46385897
83	CSNK1A1L	0.46108363
84	CSNK2A2	0.46003720
85	KIT	0.44005155
86	IKBKE	0.43197111
87	CHUK	0.42289093
88	OBSCN	0.42068917
89	PRKACA	0.40324936
90	ABL1	0.39004433
91	PRKCA	0.38907291
92	CSNK1A1	0.37486499
93	PIK3CG	0.36816813
94	MUSK	0.34307984
95	GRK5	0.34028533
96	MAP3K14	0.32350824
97	CAMKK2	0.32143214
98	PTK2B	0.32080198
99	AURKB	0.30744631
100	PAK3	0.30383138

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.30898696
2	Ribosome_Homo sapiens_hsa03010	3.19503222
3	Asthma_Homo sapiens_hsa05310	3.05437602
4	Proteasome_Homo sapiens_hsa03050	3.01935335
5	Parkinsons disease_Homo sapiens_hsa05012	2.65853539
6	RNA polymerase_Homo sapiens_hsa03020	2.58606647
7	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.36238647
8	Allograft rejection_Homo sapiens_hsa05330	2.34246516
9	Protein export_Homo sapiens_hsa03060	2.25906554
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.16334221
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.04330026
12	Type I diabetes mellitus_Homo sapiens_hsa04940	1.97175737
13	One carbon pool by folate_Homo sapiens_hsa00670	1.95256733
14	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80300725
15	Propanoate metabolism_Homo sapiens_hsa00640	1.77754984
16	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.69681647
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.66881600
18	Alzheimers disease_Homo sapiens_hsa05010	1.61822422
19	Huntingtons disease_Homo sapiens_hsa05016	1.60203172
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.55738556
21	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.54994914
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.50723210
23	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.49580981
24	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.48566635
25	Sulfur metabolism_Homo sapiens_hsa00920	1.44655419
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.43255410
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.34903955
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.34037059
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33858072
30	Selenocompound metabolism_Homo sapiens_hsa00450	1.31182436
31	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.30337619
32	RNA degradation_Homo sapiens_hsa03018	1.28464079
33	Homologous recombination_Homo sapiens_hsa03440	1.28176895
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.26590954
35	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25056748
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.23072121
37	Butanoate metabolism_Homo sapiens_hsa00650	1.19105672
38	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.16450460
39	Peroxisome_Homo sapiens_hsa04146	1.15722798
40	Basal transcription factors_Homo sapiens_hsa03022	1.15587620
41	Phototransduction_Homo sapiens_hsa04744	1.13394816
42	Purine metabolism_Homo sapiens_hsa00230	1.10390737
43	Rheumatoid arthritis_Homo sapiens_hsa05323	1.09777306
44	Nitrogen metabolism_Homo sapiens_hsa00910	1.01911994
45	Mismatch repair_Homo sapiens_hsa03430	0.98154913
46	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.96381152
47	Caffeine metabolism_Homo sapiens_hsa00232	0.95959189
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.94989690
49	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.94723140
50	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.94538620
51	Base excision repair_Homo sapiens_hsa03410	0.92711288
52	Collecting duct acid secretion_Homo sapiens_hsa04966	0.91181542
53	Antigen processing and presentation_Homo sapiens_hsa04612	0.90723681
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.89564303
55	RNA transport_Homo sapiens_hsa03013	0.86568342
56	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.84815094
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.81273365
58	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.81208290
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.81201973
60	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80666050
61	Metabolic pathways_Homo sapiens_hsa01100	0.79747317
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.79163350
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.78472806
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.77347079
65	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.76625286
66	Sulfur relay system_Homo sapiens_hsa04122	0.76548693
67	Regulation of autophagy_Homo sapiens_hsa04140	0.75367271
68	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.73790515
69	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72250979
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.72199700
71	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71074677
72	Folate biosynthesis_Homo sapiens_hsa00790	0.71010433
73	Fatty acid elongation_Homo sapiens_hsa00062	0.70533814
74	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.69547386
75	DNA replication_Homo sapiens_hsa03030	0.67280691
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66416370
77	Glutathione metabolism_Homo sapiens_hsa00480	0.66368910
78	Spliceosome_Homo sapiens_hsa03040	0.66335118
79	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64131781
80	Retinol metabolism_Homo sapiens_hsa00830	0.61644115
81	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.59504026
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.59457195
83	Fatty acid degradation_Homo sapiens_hsa00071	0.57385527
84	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56286413
85	Pyruvate metabolism_Homo sapiens_hsa00620	0.49041126
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48675710
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48066778
88	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.47755451
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.42781868
90	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.41271125
91	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.41256874
92	Viral myocarditis_Homo sapiens_hsa05416	0.40483323
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.38757573
94	Fatty acid metabolism_Homo sapiens_hsa01212	0.38261550
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.35484571
96	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.33963572
97	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.32419761
98	Olfactory transduction_Homo sapiens_hsa04740	0.31846071
99	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30130353
100	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.30103983

RPL3P8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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