RPL3P9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)5.37300926
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)5.36560124
3tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)5.36560124
4ribosomal small subunit assembly (GO:0000028)5.31217006
5translational termination (GO:0006415)5.26037592
6DNA deamination (GO:0045006)4.84946983
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.70488509
8translational elongation (GO:0006414)4.67073527
9cotranslational protein targeting to membrane (GO:0006613)4.64339983
10protein targeting to ER (GO:0045047)4.61241013
11behavioral response to nicotine (GO:0035095)4.58094889
12ATP synthesis coupled proton transport (GO:0015986)4.53516048
13energy coupled proton transport, down electrochemical gradient (GO:0015985)4.53516048
14establishment of protein localization to endoplasmic reticulum (GO:0072599)4.41065249
15ribosomal small subunit biogenesis (GO:0042274)4.37112830
16protein localization to endoplasmic reticulum (GO:0070972)4.32795240
17protein complex biogenesis (GO:0070271)4.26330649
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.18759815
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.13228941
20mitochondrial respiratory chain complex assembly (GO:0033108)4.03365705
21fucose catabolic process (GO:0019317)3.94727811
22L-fucose metabolic process (GO:0042354)3.94727811
23L-fucose catabolic process (GO:0042355)3.94727811
24CTP biosynthetic process (GO:0006241)3.92045304
25CTP metabolic process (GO:0046036)3.92045304
26water-soluble vitamin biosynthetic process (GO:0042364)3.87907773
27cellular protein complex disassembly (GO:0043624)3.85325160
28viral life cycle (GO:0019058)3.84711318
29regulation of memory T cell differentiation (GO:0043380)3.82079021
30chaperone-mediated protein transport (GO:0072321)3.73252294
31regulation of activation of Janus kinase activity (GO:0010533)3.68576213
32translational initiation (GO:0006413)3.67582162
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.63921133
34positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.62384585
35maturation of SSU-rRNA (GO:0030490)3.57684763
36translation (GO:0006412)3.55337000
37DNA double-strand break processing (GO:0000729)3.53903622
38ribosomal large subunit biogenesis (GO:0042273)3.53063657
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51785473
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.50925915
41nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47523162
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.45148178
43cytochrome complex assembly (GO:0017004)3.44848527
44pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.36707261
45pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.33397915
46pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.30468949
47rRNA modification (GO:0000154)3.26595730
48mitochondrial respiratory chain complex I assembly (GO:0032981)3.26093612
49NADH dehydrogenase complex assembly (GO:0010257)3.26093612
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.26093612
51GTP biosynthetic process (GO:0006183)3.25875092
52pseudouridine synthesis (GO:0001522)3.25457588
53nucleotide salvage (GO:0043173)3.22032779
54regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.21110726
55respiratory chain complex IV assembly (GO:0008535)3.19169285
56protein complex disassembly (GO:0043241)3.17326057
57electron transport chain (GO:0022900)3.16970505
58regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.16175627
59tRNA processing (GO:0008033)3.12939158
60respiratory electron transport chain (GO:0022904)3.10841425
61positive regulation of cell fate commitment (GO:0010455)3.10448624
62protein neddylation (GO:0045116)3.10064125
63nucleoside salvage (GO:0043174)3.05652985
64macromolecular complex disassembly (GO:0032984)3.00050684
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.95970364
66cellular component biogenesis (GO:0044085)2.95875942
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.95578857
68preassembly of GPI anchor in ER membrane (GO:0016254)2.94150760
69positive regulation of T-helper 1 type immune response (GO:0002827)2.92939153
70L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92891412
71DNA catabolic process, exonucleolytic (GO:0000738)2.87913231
72protein targeting to membrane (GO:0006612)2.87149170
73signal peptide processing (GO:0006465)2.86179382
74nuclear-transcribed mRNA catabolic process (GO:0000956)2.86063616
75ribonucleoside triphosphate biosynthetic process (GO:0009201)2.85402187
76pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.84407087
77pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.80853558
78transcription elongation from RNA polymerase III promoter (GO:0006385)2.80363420
79termination of RNA polymerase III transcription (GO:0006386)2.80363420
80positive regulation of defense response to virus by host (GO:0002230)2.78234134
81pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)2.77963892
82UMP metabolic process (GO:0046049)2.77963892
83pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)2.77963892
84UMP biosynthetic process (GO:0006222)2.77963892
85positive regulation of interleukin-17 production (GO:0032740)2.74642129
86UTP biosynthetic process (GO:0006228)2.74030569
87rRNA processing (GO:0006364)2.73692207
88purine nucleoside triphosphate biosynthetic process (GO:0009145)2.71632405
89purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.71527142
90rRNA methylation (GO:0031167)2.71510804
91rRNA metabolic process (GO:0016072)2.69600134
92intracellular protein transmembrane import (GO:0044743)2.69458043
93piRNA metabolic process (GO:0034587)2.69420728
94pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.67812353
95ribonucleoprotein complex biogenesis (GO:0022613)2.66756619
96mRNA catabolic process (GO:0006402)2.66474343
97pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.66444570
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.65818015
99mannosylation (GO:0097502)2.64040853
100L-methionine biosynthetic process (GO:0071265)2.62800690

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99877225
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.91176424
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.48864131
4ZNF274_21170338_ChIP-Seq_K562_Hela3.34978345
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94378078
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.74759677
7VDR_22108803_ChIP-Seq_LS180_Human2.74530149
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61737709
9MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59515488
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.59325327
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46517184
12E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.41100877
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30376464
14ELK1_19687146_ChIP-ChIP_HELA_Human2.27451116
15VDR_23849224_ChIP-Seq_CD4+_Human2.26926801
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.17033561
17IGF1R_20145208_ChIP-Seq_DFB_Human2.13881770
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.09476330
19FOXP3_21729870_ChIP-Seq_TREG_Human1.99212825
20MYC_18555785_ChIP-Seq_MESCs_Mouse1.97879390
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.95130601
22EWS_26573619_Chip-Seq_HEK293_Human1.94481489
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.90920884
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87735332
25MYC_18940864_ChIP-ChIP_HL60_Human1.81578266
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75069217
27CREB1_15753290_ChIP-ChIP_HEK293T_Human1.71425672
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70049337
29TP53_22573176_ChIP-Seq_HFKS_Human1.65050797
30NOTCH1_21737748_ChIP-Seq_TLL_Human1.55149215
31PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48588072
32IRF1_19129219_ChIP-ChIP_H3396_Human1.46417494
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.45995488
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.45947492
35EZH2_22144423_ChIP-Seq_EOC_Human1.45764226
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45096773
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44347310
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43104904
39FUS_26573619_Chip-Seq_HEK293_Human1.41609155
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.34267247
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34267247
42TTF2_22483619_ChIP-Seq_HELA_Human1.34141325
43NANOG_19829295_ChIP-Seq_ESCs_Human1.32623722
44SOX2_19829295_ChIP-Seq_ESCs_Human1.32623722
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31793601
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31736534
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30846975
48P300_19829295_ChIP-Seq_ESCs_Human1.29574234
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26935549
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.25670370
51AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21844043
52BP1_19119308_ChIP-ChIP_Hs578T_Human1.20562764
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.18042816
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16769146
55AR_20517297_ChIP-Seq_VCAP_Human1.15529282
56NCOR_22424771_ChIP-Seq_293T_Human1.15337249
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14959955
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14747253
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.11564062
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.11092693
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.09931441
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09648535
63CBP_20019798_ChIP-Seq_JUKART_Human1.07523365
64IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07523365
65TAF15_26573619_Chip-Seq_HEK293_Human1.06636409
66CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06288964
67GATA3_26560356_Chip-Seq_TH2_Human1.05917437
68MYC_19829295_ChIP-Seq_ESCs_Human1.05215666
69ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04913157
70NANOG_20526341_ChIP-Seq_ESCs_Human1.04205385
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04032826
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03387081
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03008044
74ER_23166858_ChIP-Seq_MCF-7_Human1.02316251
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01821912
76BCAT_22108803_ChIP-Seq_LS180_Human1.01713746
77THAP11_20581084_ChIP-Seq_MESCs_Mouse1.01617745
78HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00059117
79GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99796814
80ELK1_22589737_ChIP-Seq_MCF10A_Human0.99757718
81EZH2_27294783_Chip-Seq_NPCs_Mouse0.99689440
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99621042
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99262585
84IKZF1_21737484_ChIP-ChIP_HCT116_Human0.98619889
85TAF2_19829295_ChIP-Seq_ESCs_Human0.98326421
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.98251271
87XRN2_22483619_ChIP-Seq_HELA_Human0.96733689
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.96075615
89ERA_21632823_ChIP-Seq_H3396_Human0.95014586
90POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93011204
91KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92675350
92MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91681231
93P53_21459846_ChIP-Seq_SAOS-2_Human0.91231747
94GATA6_21074721_ChIP-Seq_CACO-2_Human0.90526038
95HTT_18923047_ChIP-ChIP_STHdh_Human0.89472603
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88905360
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.88514911
98REST_21632747_ChIP-Seq_MESCs_Mouse0.88339072
99FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88038335
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87332237

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode3.45590255
2MP0009379_abnormal_foot_pigmentation3.27867247
3MP0008875_abnormal_xenobiotic_pharmacok2.99556813
4MP0005360_urolithiasis2.77886649
5MP0004885_abnormal_endolymph2.57691779
6MP0006072_abnormal_retinal_apoptosis2.55439164
7MP0003646_muscle_fatigue2.53296918
8MP0008872_abnormal_physiological_respon2.36703902
9MP0008877_abnormal_DNA_methylation2.34786491
10MP0002102_abnormal_ear_morphology2.27008745
11MP0002837_dystrophic_cardiac_calcinosis2.24217431
12MP0002163_abnormal_gland_morphology2.22725121
13MP0002638_abnormal_pupillary_reflex2.13300628
14MP0001986_abnormal_taste_sensitivity2.03441196
15MP0003787_abnormal_imprinting2.01265779
16MP0002876_abnormal_thyroid_physiology1.93572015
17MP0005551_abnormal_eye_electrophysiolog1.90422440
18MP0004142_abnormal_muscle_tone1.90253958
19MP0001968_abnormal_touch/_nociception1.88564552
20MP0005084_abnormal_gallbladder_morpholo1.83090314
21MP0003195_calcinosis1.81022185
22MP0005645_abnormal_hypothalamus_physiol1.77473789
23MP0002736_abnormal_nociception_after1.74708738
24MP0002138_abnormal_hepatobiliary_system1.64547615
25MP0005379_endocrine/exocrine_gland_phen1.64507378
26MP0004147_increased_porphyrin_level1.63866111
27MP0003718_maternal_effect1.56935408
28MP0005671_abnormal_response_to1.55642918
29MP0005389_reproductive_system_phenotype1.53924958
30MP0001501_abnormal_sleep_pattern1.52620355
31MP0001984_abnormal_olfaction1.51642232
32MP0002277_abnormal_respiratory_mucosa1.42667565
33MP0001905_abnormal_dopamine_level1.42082696
34MP0010386_abnormal_urinary_bladder1.39574407
35MP0008058_abnormal_DNA_repair1.39544511
36MP0003011_delayed_dark_adaptation1.38375177
37MP0009046_muscle_twitch1.36537967
38MP0002160_abnormal_reproductive_system1.35036069
39MP0000372_irregular_coat_pigmentation1.33687320
40MP0006276_abnormal_autonomic_nervous1.32367188
41MP0009785_altered_susceptibility_to1.29402188
42MP0005075_abnormal_melanosome_morpholog1.28426995
43MP0009745_abnormal_behavioral_response1.27411921
44MP0002272_abnormal_nervous_system1.26727868
45MP0005253_abnormal_eye_physiology1.25838489
46MP0002234_abnormal_pharynx_morphology1.24781979
47MP0001835_abnormal_antigen_presentation1.24459364
48MP0005387_immune_system_phenotype1.19719240
49MP0001790_abnormal_immune_system1.19719240
50MP0001919_abnormal_reproductive_system1.18867449
51MP0003121_genomic_imprinting1.16847972
52MP0005332_abnormal_amino_acid1.16355160
53MP0000631_abnormal_neuroendocrine_gland1.15082664
54MP0004145_abnormal_muscle_electrophysio1.14570148
55MP0003283_abnormal_digestive_organ1.13728618
56MP0005636_abnormal_mineral_homeostasis1.10545382
57MP0003567_abnormal_fetal_cardiomyocyte1.09069990
58MP0005646_abnormal_pituitary_gland1.08871318
59MP0002148_abnormal_hypersensitivity_rea1.08344864
60MP0002938_white_spotting1.08238560
61MP0003122_maternal_imprinting1.05257207
62MP0006036_abnormal_mitochondrial_physio1.05044287
63MP0000538_abnormal_urinary_bladder1.04386303
64MP0002095_abnormal_skin_pigmentation1.03325012
65MP0002909_abnormal_adrenal_gland0.99205128
66MP0003786_premature_aging0.98411733
67MP0008789_abnormal_olfactory_epithelium0.97910138
68MP0001873_stomach_inflammation0.95697034
69MP0001756_abnormal_urination0.95252125
70MP0003186_abnormal_redox_activity0.93787310
71MP0001485_abnormal_pinna_reflex0.92590648
72MP0003252_abnormal_bile_duct0.91099457
73MP0008775_abnormal_heart_ventricle0.89535114
74MP0005000_abnormal_immune_tolerance0.89252634
75MP0001800_abnormal_humoral_immune0.89182371
76MP0004019_abnormal_vitamin_homeostasis0.87862881
77MP0002693_abnormal_pancreas_physiology0.87068741
78MP0001293_anophthalmia0.87043015
79MP0003880_abnormal_central_pattern0.86452448
80MP0001970_abnormal_pain_threshold0.84916426
81MP0005085_abnormal_gallbladder_physiolo0.84252823
82MP0000427_abnormal_hair_cycle0.83115611
83MP0004133_heterotaxia0.79457812
84MP0010329_abnormal_lipoprotein_level0.78775031
85MP0001944_abnormal_pancreas_morphology0.78233735
86MP0004043_abnormal_pH_regulation0.77913361
87MP0005167_abnormal_blood-brain_barrier0.77546425
88MP0003638_abnormal_response/metabolism_0.76982832
89MP0001765_abnormal_ion_homeostasis0.76570123
90MP0004742_abnormal_vestibular_system0.76486290
91MP0000685_abnormal_immune_system0.74584907
92MP0000230_abnormal_systemic_arterial0.74256682
93MP0009643_abnormal_urine_homeostasis0.74015703
94MP0005195_abnormal_posterior_eye0.71661349
95MP0002733_abnormal_thermal_nociception0.71085648
96MP0001502_abnormal_circadian_rhythm0.70224611
97MP0002006_tumorigenesis0.70110505
98MP0005410_abnormal_fertilization0.70074214
99MP0002229_neurodegeneration0.69097421
100MP0002735_abnormal_chemical_nociception0.68585656

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.98716352
2Increased hepatocellular lipid droplets (HP:0006565)3.88871725
3Lipid accumulation in hepatocytes (HP:0006561)3.71687290
4Pancreatic fibrosis (HP:0100732)3.66905636
5Pancreatic cysts (HP:0001737)3.66457086
6Mitochondrial inheritance (HP:0001427)3.56859933
7Abnormal mitochondria in muscle tissue (HP:0008316)3.46936365
8Progressive macrocephaly (HP:0004481)3.43029118
9Acute encephalopathy (HP:0006846)3.40666829
10Increased CSF lactate (HP:0002490)3.25937988
11Abnormality of midbrain morphology (HP:0002418)3.23499196
12Molar tooth sign on MRI (HP:0002419)3.23499196
13Congenital stationary night blindness (HP:0007642)3.21836211
14Renal Fanconi syndrome (HP:0001994)3.14719814
15IgG deficiency (HP:0004315)3.06307241
16Nephronophthisis (HP:0000090)2.97420451
17Abnormal biliary tract physiology (HP:0012439)2.97077065
18Bile duct proliferation (HP:0001408)2.97077065
19Abnormal rod and cone electroretinograms (HP:0008323)2.96058324
20Congenital, generalized hypertrichosis (HP:0004540)2.85852905
21Hypoplasia of the pons (HP:0012110)2.85422694
22Abnormality of the renal cortex (HP:0011035)2.82715943
23True hermaphroditism (HP:0010459)2.80109585
24Reticulocytopenia (HP:0001896)2.77667960
25Absent rod-and cone-mediated responses on ERG (HP:0007688)2.77301900
26Abnormality of the pons (HP:0007361)2.75801291
27Aplasia/Hypoplasia of the spleen (HP:0010451)2.74298154
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.71452629
29Stomatitis (HP:0010280)2.68180289
30Abnormal drinking behavior (HP:0030082)2.67184298
31Polydipsia (HP:0001959)2.67184298
32Asplenia (HP:0001746)2.63871688
33Exertional dyspnea (HP:0002875)2.62988290
34Hepatic necrosis (HP:0002605)2.62797018
35Hepatocellular necrosis (HP:0001404)2.62172184
36Pendular nystagmus (HP:0012043)2.58285992
37Abnormality of the renal medulla (HP:0100957)2.56765713
38Cerebral edema (HP:0002181)2.52692654
39Abnormality of cells of the erythroid lineage (HP:0012130)2.50857685
40Increased intramyocellular lipid droplets (HP:0012240)2.50436140
41Abnormal number of erythroid precursors (HP:0012131)2.48640473
42Methylmalonic acidemia (HP:0002912)2.47548977
43Macrocytic anemia (HP:0001972)2.46347527
44Medial flaring of the eyebrow (HP:0010747)2.42072265
45Tubular atrophy (HP:0000092)2.32613253
46Hyperglycinemia (HP:0002154)2.32050506
47Parakeratosis (HP:0001036)2.30305739
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.28434158
49Erythroderma (HP:0001019)2.25621752
50Polyuria (HP:0000103)2.24653625
51Aplasia/hypoplasia of the uterus (HP:0008684)2.24418407
523-Methylglutaconic aciduria (HP:0003535)2.23899782
53Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.22064435
54Abnormality of renal resorption (HP:0011038)2.21759338
55Optic disc pallor (HP:0000543)2.19840592
56Abolished electroretinogram (ERG) (HP:0000550)2.18983541
57Cystic liver disease (HP:0006706)2.17875034
58Glycosuria (HP:0003076)2.17710927
59Abnormality of urine glucose concentration (HP:0011016)2.17710927
60Increased muscle lipid content (HP:0009058)2.13384022
61Panhypogammaglobulinemia (HP:0003139)2.12549488
62Poor suck (HP:0002033)2.10688252
63Increased serum lactate (HP:0002151)2.08686993
64Renal cortical cysts (HP:0000803)2.07266434
65Supernumerary spleens (HP:0009799)2.07123871
66Type II lissencephaly (HP:0007260)2.06567036
67Hypomagnesemia (HP:0002917)2.06497174
68Pallor (HP:0000980)2.04278889
69Methylmalonic aciduria (HP:0012120)2.04048880
70Decreased central vision (HP:0007663)2.02323470
71Attenuation of retinal blood vessels (HP:0007843)2.01103725
72Absent thumb (HP:0009777)1.97691374
73Opisthotonus (HP:0002179)1.97042444
74Keratoconus (HP:0000563)1.91071740
75Increased corneal curvature (HP:0100692)1.91071740
76Lactic acidosis (HP:0003128)1.90494252
77Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89806244
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89806244
79Lethargy (HP:0001254)1.87467971
80Hypoplasia of the uterus (HP:0000013)1.87174328
81Sclerocornea (HP:0000647)1.85921468
82Respiratory failure (HP:0002878)1.82502941
83B lymphocytopenia (HP:0010976)1.81905133
84Abnormal urine output (HP:0012590)1.81553206
85Abnormality of B cell number (HP:0010975)1.81483265
86Anencephaly (HP:0002323)1.81476305
87Thyroiditis (HP:0100646)1.80426045
88Adrenal hypoplasia (HP:0000835)1.80399780
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80303172
90Abnormality of alanine metabolism (HP:0010916)1.80303172
91Hyperalaninemia (HP:0003348)1.80303172
92Large for gestational age (HP:0001520)1.79925248
93Degeneration of anterior horn cells (HP:0002398)1.79821343
94Abnormality of the anterior horn cell (HP:0006802)1.79821343
95Hyperphosphaturia (HP:0003109)1.79197083
96Hyperinsulinemic hypoglycemia (HP:0000825)1.76010659
97Leukodystrophy (HP:0002415)1.75499514
98Dyskinesia (HP:0100660)1.73882079
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72484367
100Gait imbalance (HP:0002141)1.72324227

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK23.36596774
2FRK3.27643666
3GRK12.87929797
4BMPR1B2.87609096
5VRK22.79815072
6TAOK32.61113268
7ZAK2.52577881
8NUAK12.51969263
9TXK2.51843719
10WNK42.50983610
11STK162.47865161
12TLK12.46208643
13MAP4K22.06790712
14MST41.99658661
15TIE11.94373238
16MAP4K11.67676824
17TAF11.67345351
18PASK1.65957637
19STK391.57040285
20PHKG11.56813140
21PHKG21.56813140
22VRK11.55077866
23WNK31.44938636
24OXSR11.44433585
25BCKDK1.35021507
26PLK21.34698192
27PLK31.33256884
28ITK1.30021145
29NME11.28298110
30TEC1.28014161
31TNIK1.20566643
32NME21.19007803
33LIMK11.18095123
34MAP2K61.15998598
35EIF2AK31.15893644
36PRKCG1.14871400
37PINK11.14856117
38EIF2AK11.13440124
39DYRK21.09837912
40NLK1.08077465
41TGFBR11.05554859
42ADRBK11.05199372
43CDC71.04684408
44INSRR0.97369954
45NEK10.97304982
46TSSK60.95103730
47ACVR1B0.93411112
48STK30.89880248
49DAPK20.86630392
50GRK70.86393639
51TRIM280.82869927
52IKBKB0.82760396
53CSNK1G10.82017823
54KIT0.79446275
55MAP3K120.74665405
56PRKCQ0.71523498
57MAPKAPK30.67320156
58PBK0.67229341
59MAPKAPK50.66545443
60BUB10.65254204
61PRKCE0.63576766
62RPS6KA50.63150638
63CDK190.63118032
64FGFR20.62448255
65CSNK2A20.59152582
66MAP3K90.58698610
67OBSCN0.57915022
68CSNK2A10.55707765
69IKBKE0.54049346
70MKNK20.52820850
71PLK40.52034140
72SYK0.51348179
73MKNK10.50630725
74FES0.50103946
75PIK3CA0.49349649
76PRKACA0.47716173
77LCK0.47657209
78GRK60.46284674
79PRKCA0.46252231
80PLK10.44339211
81PIK3CG0.43856708
82CSNK1G30.43526590
83LYN0.42709934
84MAPK130.42277081
85SRPK10.42067633
86PRKCI0.40727105
87GRK50.39638119
88MAP3K40.38171214
89MAP3K130.37871016
90CSNK1A10.37310058
91STK40.34564012
92DAPK30.33879509
93MYLK0.33846547
94CSNK1G20.33721906
95IGF1R0.33488745
96CAMK2D0.32840286
97EIF2AK20.32618608
98FLT30.30812503
99LRRK20.30294937
100WNK10.29603587

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.74154683
2Oxidative phosphorylation_Homo sapiens_hsa001903.32122313
3Proteasome_Homo sapiens_hsa030502.72115159
4Parkinsons disease_Homo sapiens_hsa050122.67456560
5Protein export_Homo sapiens_hsa030602.51817025
6RNA polymerase_Homo sapiens_hsa030202.35441319
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.16087232
8Basal transcription factors_Homo sapiens_hsa030222.04110409
9Asthma_Homo sapiens_hsa053102.01735904
10Sulfur relay system_Homo sapiens_hsa041221.91910905
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.88740101
12RNA degradation_Homo sapiens_hsa030181.85221354
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.80038122
14Alzheimers disease_Homo sapiens_hsa050101.69620622
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.68467461
16Huntingtons disease_Homo sapiens_hsa050161.67418151
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.66478948
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.63973903
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.58120894
20Primary immunodeficiency_Homo sapiens_hsa053401.57453369
21Linoleic acid metabolism_Homo sapiens_hsa005911.55970909
22Allograft rejection_Homo sapiens_hsa053301.55831219
23Pyrimidine metabolism_Homo sapiens_hsa002401.55397066
24Phototransduction_Homo sapiens_hsa047441.54576954
25Homologous recombination_Homo sapiens_hsa034401.52344157
26Autoimmune thyroid disease_Homo sapiens_hsa053201.51187419
27Type I diabetes mellitus_Homo sapiens_hsa049401.50339576
28Cardiac muscle contraction_Homo sapiens_hsa042601.47156793
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44871985
30Butanoate metabolism_Homo sapiens_hsa006501.44534526
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.42555673
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42257221
33One carbon pool by folate_Homo sapiens_hsa006701.37588665
34Tryptophan metabolism_Homo sapiens_hsa003801.37192297
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.30291362
36Caffeine metabolism_Homo sapiens_hsa002321.29608851
37Sulfur metabolism_Homo sapiens_hsa009201.25941866
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23921119
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16560366
40Propanoate metabolism_Homo sapiens_hsa006401.15667983
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.15281370
42Nitrogen metabolism_Homo sapiens_hsa009101.11982723
43Fanconi anemia pathway_Homo sapiens_hsa034601.10782594
44Arachidonic acid metabolism_Homo sapiens_hsa005901.05602947
45Graft-versus-host disease_Homo sapiens_hsa053321.04558793
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02943633
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.02861750
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.02285575
49Purine metabolism_Homo sapiens_hsa002301.00874109
50Mismatch repair_Homo sapiens_hsa034300.99708329
51RNA transport_Homo sapiens_hsa030130.97314845
52Non-homologous end-joining_Homo sapiens_hsa034500.96872820
53Collecting duct acid secretion_Homo sapiens_hsa049660.95654165
54Peroxisome_Homo sapiens_hsa041460.95226374
55Chemical carcinogenesis_Homo sapiens_hsa052040.92284458
56Nucleotide excision repair_Homo sapiens_hsa034200.92243396
57Rheumatoid arthritis_Homo sapiens_hsa053230.90877201
58Selenocompound metabolism_Homo sapiens_hsa004500.90867275
59DNA replication_Homo sapiens_hsa030300.90340432
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90122101
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85855234
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84493482
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.80694136
64Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80288332
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80229951
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77915462
67Retinol metabolism_Homo sapiens_hsa008300.76619522
68Fat digestion and absorption_Homo sapiens_hsa049750.76613600
69Base excision repair_Homo sapiens_hsa034100.75610407
70Metabolic pathways_Homo sapiens_hsa011000.75585639
71Hematopoietic cell lineage_Homo sapiens_hsa046400.72029148
72Vitamin B6 metabolism_Homo sapiens_hsa007500.71864705
73Spliceosome_Homo sapiens_hsa030400.68239630
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.67951738
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.64198335
76Ether lipid metabolism_Homo sapiens_hsa005650.64112884
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62899130
78Folate biosynthesis_Homo sapiens_hsa007900.62842370
79Olfactory transduction_Homo sapiens_hsa047400.62470859
80Pyruvate metabolism_Homo sapiens_hsa006200.58777468
81Glycerolipid metabolism_Homo sapiens_hsa005610.57628572
82Fatty acid elongation_Homo sapiens_hsa000620.56346787
83beta-Alanine metabolism_Homo sapiens_hsa004100.54771987
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53402113
85Fatty acid degradation_Homo sapiens_hsa000710.50660082
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47702186
87Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46664700
88Glutathione metabolism_Homo sapiens_hsa004800.44233110
89Taste transduction_Homo sapiens_hsa047420.43102784
90Nicotine addiction_Homo sapiens_hsa050330.42969486
91Morphine addiction_Homo sapiens_hsa050320.41056490
92Insulin secretion_Homo sapiens_hsa049110.40830288
93Serotonergic synapse_Homo sapiens_hsa047260.40067049
94Antigen processing and presentation_Homo sapiens_hsa046120.38646614
95Ovarian steroidogenesis_Homo sapiens_hsa049130.37421313
96Regulation of autophagy_Homo sapiens_hsa041400.34593844
97Arginine and proline metabolism_Homo sapiens_hsa003300.33962060
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.30643990
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.30493665
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.30152534

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