RPL4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.17708475
2* viral transcription (GO:0019083)5.17304514
3* translational termination (GO:0006415)5.06606469
4DNA unwinding involved in DNA replication (GO:0006268)4.92899675
5maturation of SSU-rRNA (GO:0030490)4.91658639
6DNA strand elongation involved in DNA replication (GO:0006271)4.64212542
7formation of translation preinitiation complex (GO:0001731)4.64033558
8* translational elongation (GO:0006414)4.62944046
9ribosomal small subunit biogenesis (GO:0042274)4.56939095
10DNA strand elongation (GO:0022616)4.41913669
11DNA replication initiation (GO:0006270)4.34224591
12* translational initiation (GO:0006413)4.30462457
13* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.29911584
14* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.29867650
15telomere maintenance via semi-conservative replication (GO:0032201)4.25834297
16ribosomal large subunit biogenesis (GO:0042273)4.22281149
17* protein targeting to ER (GO:0045047)4.17243863
18* cotranslational protein targeting to membrane (GO:0006613)4.16985534
19IMP biosynthetic process (GO:0006188)4.02418517
20nucleobase biosynthetic process (GO:0046112)3.99380262
21* establishment of protein localization to endoplasmic reticulum (GO:0072599)3.97020257
22* cellular protein complex disassembly (GO:0043624)3.95148309
23* viral life cycle (GO:0019058)3.92085451
24protein localization to kinetochore (GO:0034501)3.92039629
25* protein localization to endoplasmic reticulum (GO:0070972)3.88917477
26heterochromatin organization (GO:0070828)3.83820783
27ribonucleoprotein complex biogenesis (GO:0022613)3.80761306
28folic acid-containing compound biosynthetic process (GO:0009396)3.80720772
29telomere maintenance via recombination (GO:0000722)3.80222269
30mitotic nuclear envelope disassembly (GO:0007077)3.73585274
31DNA topological change (GO:0006265)3.71249520
32mitotic recombination (GO:0006312)3.67887732
33nuclear pore organization (GO:0006999)3.66568306
34* protein complex disassembly (GO:0043241)3.63055857
35IMP metabolic process (GO:0046040)3.61589470
36DNA replication checkpoint (GO:0000076)3.60040280
37purine nucleobase biosynthetic process (GO:0009113)3.59965888
38telomere maintenance via telomere lengthening (GO:0010833)3.51067819
39membrane disassembly (GO:0030397)3.45936706
40nuclear envelope disassembly (GO:0051081)3.45936706
41nuclear pore complex assembly (GO:0051292)3.45548119
42ribosome biogenesis (GO:0042254)3.42219946
43ribosome assembly (GO:0042255)3.41260264
44* macromolecular complex disassembly (GO:0032984)3.41178741
45* nuclear-transcribed mRNA catabolic process (GO:0000956)3.40285135
46regulation of RNA export from nucleus (GO:0046831)3.39014207
47mitotic metaphase plate congression (GO:0007080)3.37958090
48protein localization to chromosome, centromeric region (GO:0071459)3.34951493
49nucleotide-excision repair, DNA gap filling (GO:0006297)3.34827522
50DNA duplex unwinding (GO:0032508)3.34251129
51DNA geometric change (GO:0032392)3.32382342
52DNA deamination (GO:0045006)3.32358336
53DNA replication-dependent nucleosome assembly (GO:0006335)3.32202298
54DNA replication-dependent nucleosome organization (GO:0034723)3.32202298
55negative regulation of mRNA processing (GO:0050686)3.25631194
56rRNA processing (GO:0006364)3.24879880
57chromatin remodeling at centromere (GO:0031055)3.24076300
58* mRNA catabolic process (GO:0006402)3.22888457
59CENP-A containing nucleosome assembly (GO:0034080)3.22821464
60spliceosomal tri-snRNP complex assembly (GO:0000244)3.22346769
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.20313421
62* RNA catabolic process (GO:0006401)3.17759048
63DNA synthesis involved in DNA repair (GO:0000731)3.14502529
64rRNA metabolic process (GO:0016072)3.14288841
65DNA replication-independent nucleosome assembly (GO:0006336)3.13621361
66DNA replication-independent nucleosome organization (GO:0034724)3.13621361
67negative regulation of mRNA metabolic process (GO:1903312)3.12905923
68viral mRNA export from host cell nucleus (GO:0046784)3.12109562
69metaphase plate congression (GO:0051310)3.11257864
70RNA stabilization (GO:0043489)3.10888800
71mRNA stabilization (GO:0048255)3.10888800
72regulation of DNA damage checkpoint (GO:2000001)3.09880553
73mitotic chromosome condensation (GO:0007076)3.09128155
74* translation (GO:0006412)3.09094309
75negative regulation of DNA repair (GO:0045738)3.05751643
76regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.05385139
77somatic diversification of immune receptors via somatic mutation (GO:0002566)3.04777071
78somatic hypermutation of immunoglobulin genes (GO:0016446)3.04777071
79positive regulation of chromosome segregation (GO:0051984)3.04679227
80regulation of spindle organization (GO:0090224)3.03973801
81protein complex localization (GO:0031503)3.03955492
82kinetochore organization (GO:0051383)3.01867381
83chromosome condensation (GO:0030261)3.01458140
84negative regulation of RNA splicing (GO:0033119)3.00858820
85proline biosynthetic process (GO:0006561)3.00012933
86negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.99333792
87regulation of sister chromatid cohesion (GO:0007063)2.98708748
88tRNA aminoacylation for protein translation (GO:0006418)2.95687682
89peptidyl-arginine omega-N-methylation (GO:0035247)2.95435118
90pre-miRNA processing (GO:0031054)2.93646537
91protein export from nucleus (GO:0006611)2.93638200
92non-recombinational repair (GO:0000726)2.92956639
93double-strand break repair via nonhomologous end joining (GO:0006303)2.92956639
94cellular protein complex localization (GO:0034629)2.92263994
95regulation of nucleobase-containing compound transport (GO:0032239)2.90002683
96regulation of translational initiation (GO:0006446)2.89232100
97translesion synthesis (GO:0019985)2.88209008
98attachment of spindle microtubules to kinetochore (GO:0008608)2.87825945
99tRNA aminoacylation (GO:0043039)2.87412037
100amino acid activation (GO:0043038)2.87412037
101telomere maintenance (GO:0000723)2.87285663
102telomere organization (GO:0032200)2.86242526
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.85802976
104nucleosome disassembly (GO:0006337)2.84302642
105protein-DNA complex disassembly (GO:0032986)2.84302642
106chromatin assembly (GO:0031497)2.83315889
107establishment of chromosome localization (GO:0051303)2.83306020
108mitotic sister chromatid segregation (GO:0000070)2.80170246
109spliceosomal snRNP assembly (GO:0000387)2.79899677
110mRNA splicing, via spliceosome (GO:0000398)2.79104505
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.79104505
112RNA splicing, via transesterification reactions (GO:0000375)2.79072895
113regulation of histone H3-K9 methylation (GO:0051570)2.78365602
114DNA conformation change (GO:0071103)2.74598326
115postreplication repair (GO:0006301)2.74377845
116mRNA transport (GO:0051028)2.74160684
117sister chromatid segregation (GO:0000819)2.73858395
118mitotic sister chromatid cohesion (GO:0007064)2.71990846
119DNA packaging (GO:0006323)2.71912212
120pseudouridine synthesis (GO:0001522)2.70499919
121chromatin assembly or disassembly (GO:0006333)2.70090561
122* protein targeting to membrane (GO:0006612)2.68889891
123ncRNA 3-end processing (GO:0043628)2.67744257
124nuclear envelope organization (GO:0006998)2.67475213
125histone exchange (GO:0043486)2.67358142
126pore complex assembly (GO:0046931)2.67031134
127dosage compensation (GO:0007549)2.66784035
128regulation of translational fidelity (GO:0006450)2.66481447
129establishment of integrated proviral latency (GO:0075713)2.65446077
130negative regulation of histone methylation (GO:0031061)2.65054921
131transcription-coupled nucleotide-excision repair (GO:0006283)2.64836887
132regulation of helicase activity (GO:0051095)2.62008472
133cellular component biogenesis (GO:0044085)2.61760927
134intra-S DNA damage checkpoint (GO:0031573)2.60593953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.68166390
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.29387826
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.77060072
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.63149344
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38443756
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03363480
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84709107
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68987426
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.68116929
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62644402
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.61164176
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.46061912
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.41269418
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.35384177
15* XRN2_22483619_ChIP-Seq_HELA_Human2.33960803
16MYC_22102868_ChIP-Seq_BL_Human2.26426500
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25476187
18* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.25169794
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.21814661
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17045002
21VDR_23849224_ChIP-Seq_CD4+_Human2.09931477
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03704358
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95718184
24* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95147949
25E2F1_21310950_ChIP-Seq_MCF-7_Human1.93414228
26AR_21909140_ChIP-Seq_LNCAP_Human1.92000945
27FOXP3_21729870_ChIP-Seq_TREG_Human1.91154512
28* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84126176
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82902816
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.80448281
31CIITA_25753668_ChIP-Seq_RAJI_Human1.80018942
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.78431415
33DCP1A_22483619_ChIP-Seq_HELA_Human1.77775903
34* TTF2_22483619_ChIP-Seq_HELA_Human1.77375322
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69334581
36GABP_19822575_ChIP-Seq_HepG2_Human1.69037605
37NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.66957934
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66262518
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65764779
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63767229
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63089558
42ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59916221
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56289750
44ELK1_19687146_ChIP-ChIP_HELA_Human1.55230959
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50925417
46ZNF263_19887448_ChIP-Seq_K562_Human1.50467047
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.50178423
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.49047244
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46820270
50* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.44641915
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43524496
52VDR_21846776_ChIP-Seq_THP-1_Human1.42369664
53KDM5A_27292631_Chip-Seq_BREAST_Human1.41415065
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.37122876
55* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34635989
56* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34365053
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30607900
58* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.30023015
59* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27815764
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26431735
61TFEB_21752829_ChIP-Seq_HELA_Human1.24806903
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22189045
63KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21290405
64* YY1_21170310_ChIP-Seq_MESCs_Mouse1.19444961
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19138035
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18648836
67CHD1_26751641_Chip-Seq_LNCaP_Human1.18016262
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14230731
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13315716
70SPI1_23547873_ChIP-Seq_NB4_Human1.12686736
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.12047163
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.11984660
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09278455
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08038920
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.07676120
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05470569
77TCF7_22412390_ChIP-Seq_EML_Mouse1.04025110
78NCOR1_26117541_ChIP-Seq_K562_Human1.03854174
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03676010
80POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02593673
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02255506
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01507694
83CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00199671
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00110395
85* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99867047
86ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99345778
87SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99073640
88NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99035206
89SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98081840
90* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.95620209
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94600201
92KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94100171
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93739844
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93668744
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.92941197
96CLOCK_20551151_ChIP-Seq_293T_Human0.92396458
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91834723
98MAF_26560356_Chip-Seq_TH1_Human0.91233364
99UTX_26944678_Chip-Seq_JUKART_Human0.91016861
100MYB_26560356_Chip-Seq_TH2_Human0.90946246
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.90363332
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.89977129
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89102046
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88862624
105ELK3_25401928_ChIP-Seq_HUVEC_Human0.88622214
106SCL_19346495_ChIP-Seq_HPC-7_Human0.88555791
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.87779982
108MYB_26560356_Chip-Seq_TH1_Human0.87051892
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87002668
110MAF_26560356_Chip-Seq_TH2_Human0.86818848
111TP63_17297297_ChIP-ChIP_HaCaT_Human0.85535963
112MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85418256
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85161189
114MYC_18940864_ChIP-ChIP_HL60_Human0.84463092
115CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83814013
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83100989
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82165647
118NANOG_21062744_ChIP-ChIP_HESCs_Human0.81796592
119HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.81090518

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.71205736
2MP0010094_abnormal_chromosome_stability4.16705313
3MP0004957_abnormal_blastocyst_morpholog4.00667313
4MP0003111_abnormal_nucleus_morphology3.75589352
5MP0003077_abnormal_cell_cycle3.60057803
6MP0008057_abnormal_DNA_replication3.34033489
7MP0002396_abnormal_hematopoietic_system3.12262881
8MP0008058_abnormal_DNA_repair2.94346659
9MP0002009_preneoplasia2.76146276
10MP0010352_gastrointestinal_tract_polyps2.71093410
11MP0008007_abnormal_cellular_replicative2.70776082
12MP0001730_embryonic_growth_arrest2.18177481
13MP0000350_abnormal_cell_proliferation2.09891796
14MP0004808_abnormal_hematopoietic_stem2.09325381
15MP0003123_paternal_imprinting2.08102493
16MP0008932_abnormal_embryonic_tissue2.07572132
17MP0004185_abnormal_adipocyte_glucose2.00497823
18MP0003763_abnormal_thymus_physiology1.98673619
19MP0000490_abnormal_crypts_of1.97415899
20MP0010307_abnormal_tumor_latency1.91680619
21MP0003786_premature_aging1.67552300
22MP0001697_abnormal_embryo_size1.59272882
23MP0009333_abnormal_splenocyte_physiolog1.57670832
24MP0002019_abnormal_tumor_incidence1.56318275
25MP0001545_abnormal_hematopoietic_system1.55995146
26MP0005397_hematopoietic_system_phenotyp1.55995146
27MP0005380_embryogenesis_phenotype1.55434384
28MP0001672_abnormal_embryogenesis/_devel1.55434384
29MP0006054_spinal_hemorrhage1.54262599
30MP0001661_extended_life_span1.54028803
31MP0002080_prenatal_lethality1.51710518
32MP0002398_abnormal_bone_marrow1.50886091
33MP0000703_abnormal_thymus_morphology1.46981788
34MP0003984_embryonic_growth_retardation1.45785143
35MP0003567_abnormal_fetal_cardiomyocyte1.45672540
36MP0004233_abnormal_muscle_weight1.45576611
37MP0004197_abnormal_fetal_growth/weight/1.45048656
38MP0000313_abnormal_cell_death1.42806306
39MP0008877_abnormal_DNA_methylation1.42712607
40MP0002088_abnormal_embryonic_growth/wei1.42374457
41MP0002086_abnormal_extraembryonic_tissu1.39282365
42MP0002084_abnormal_developmental_patter1.36810251
43MP0002722_abnormal_immune_system1.35765775
44MP0002085_abnormal_embryonic_tissue1.34747152
45MP0005076_abnormal_cell_differentiation1.31223046
46MP0000689_abnormal_spleen_morphology1.28339680
47MP0005501_abnormal_skin_physiology1.27635981
48MP0002796_impaired_skin_barrier1.19046029
49MP0002429_abnormal_blood_cell1.15656807
50MP0002697_abnormal_eye_size1.15515907
51MP0000685_abnormal_immune_system1.15492231
52MP0001835_abnormal_antigen_presentation1.12852041
53MP0001346_abnormal_lacrimal_gland1.11604924
54MP0000858_altered_metastatic_potential1.10112177
55MP0001293_anophthalmia1.08954030
56MP0005023_abnormal_wound_healing1.08881464
57MP0001800_abnormal_humoral_immune1.07923455
58MP0000716_abnormal_immune_system1.07711617
59MP0003121_genomic_imprinting1.07084782
60MP0002166_altered_tumor_susceptibility1.04551225
61MP0009278_abnormal_bone_marrow1.02319803
62MP0009697_abnormal_copulation1.01816809
63MP0000537_abnormal_urethra_morphology1.01449507
64MP0002420_abnormal_adaptive_immunity0.96989650
65MP0000428_abnormal_craniofacial_morphol0.96103105
66MP0005671_abnormal_response_to0.95377941
67MP0003937_abnormal_limbs/digits/tail_de0.95363430
68MP0003806_abnormal_nucleotide_metabolis0.95357079
69MP0002163_abnormal_gland_morphology0.95335248
70MP0009703_decreased_birth_body0.95229922
71MP0001819_abnormal_immune_cell0.94880661
72MP0002006_tumorigenesis0.92464981
73MP0002452_abnormal_antigen_presenting0.91785213
74MP0003566_abnormal_cell_adhesion0.91574179
75MP0000566_synostosis0.90977349
76MP0002405_respiratory_system_inflammati0.89227261
77MP0010155_abnormal_intestine_physiology0.88757479
78MP0003705_abnormal_hypodermis_morpholog0.87806598
79MP0002092_abnormal_eye_morphology0.87168026
80MP0000465_gastrointestinal_hemorrhage0.87147309
81MP0001286_abnormal_eye_development0.86946403
82MP0010030_abnormal_orbit_morphology0.86159687
83MP0000477_abnormal_intestine_morphology0.85964420
84MP0001853_heart_inflammation0.85754772
85MP0003115_abnormal_respiratory_system0.84071764
86MP0002210_abnormal_sex_determination0.83504507
87MP0003453_abnormal_keratinocyte_physiol0.82902329
88MP0001873_stomach_inflammation0.82500381
89MP0005451_abnormal_body_composition0.81937278
90MP0003385_abnormal_body_wall0.81573812
91MP0000358_abnormal_cell_content/0.80490307
92MP0004858_abnormal_nervous_system0.79963333
93MP0000678_abnormal_parathyroid_gland0.79941521
94MP0000733_abnormal_muscle_development0.79854817
95MP0002723_abnormal_immune_serum0.79457045
96MP0002132_abnormal_respiratory_system0.78576349
97MP0009053_abnormal_anal_canal0.78286528
98MP0002249_abnormal_larynx_morphology0.77533063
99MP0001145_abnormal_male_reproductive0.77391462
100MP0008995_early_reproductive_senescence0.77056447
101MP0005666_abnormal_adipose_tissue0.76799409
102MP0001915_intracranial_hemorrhage0.76668994
103MP0005384_cellular_phenotype0.75388230
104MP0003866_abnormal_defecation0.75346086
105MP0005621_abnormal_cell_physiology0.74061196
106MP0001849_ear_inflammation0.73900752
107MP0002095_abnormal_skin_pigmentation0.72168598
108MP0006035_abnormal_mitochondrial_morpho0.72012285
109MP0002877_abnormal_melanocyte_morpholog0.71684953
110MP0003315_abnormal_perineum_morphology0.71652852
111MP0009379_abnormal_foot_pigmentation0.70677909
112MP0002114_abnormal_axial_skeleton0.70432127
113MP0003119_abnormal_digestive_system0.70294968
114MP0009785_altered_susceptibility_to0.70061449
115MP0004264_abnormal_extraembryonic_tissu0.69987306
116MP0010630_abnormal_cardiac_muscle0.69811207
117MP0005623_abnormal_meninges_morphology0.69610462
118MP0005075_abnormal_melanosome_morpholog0.69560862
119MP0009672_abnormal_birth_weight0.69111537
120MP0001348_abnormal_lacrimal_gland0.69048184
121MP0002111_abnormal_tail_morphology0.68958393
122MP0005220_abnormal_exocrine_pancreas0.68807263
123MP0003941_abnormal_skin_development0.68787618
124MP0003942_abnormal_urinary_system0.68279135
125MP0004782_abnormal_surfactant_physiolog0.66810804
126MP0000377_abnormal_hair_follicle0.66659907
127MP0005025_abnormal_response_to0.65869650
128MP0010234_abnormal_vibrissa_follicle0.65578464
129MP0003890_abnormal_embryonic-extraembry0.64401178
130MP0003436_decreased_susceptibility_to0.63904432
131MP0003186_abnormal_redox_activity0.62575022
132MP0003221_abnormal_cardiomyocyte_apopto0.62250115
133MP0003448_altered_tumor_morphology0.61713372
134MP0003943_abnormal_hepatobiliary_system0.61206230
135MP0005000_abnormal_immune_tolerance0.61137099

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.10682536
2Abnormality of cells of the erythroid lineage (HP:0012130)5.00315399
3Abnormal number of erythroid precursors (HP:0012131)4.62773175
4Colon cancer (HP:0003003)4.15058397
5Birth length less than 3rd percentile (HP:0003561)3.90037145
6Thrombocytosis (HP:0001894)3.86140855
7Aplastic anemia (HP:0001915)3.36552935
8Medulloblastoma (HP:0002885)3.28509816
9Ependymoma (HP:0002888)3.26968429
10Selective tooth agenesis (HP:0001592)3.24033794
11Macrocytic anemia (HP:0001972)3.17671794
12Oral leukoplakia (HP:0002745)3.15545611
13Pallor (HP:0000980)3.15067450
1411 pairs of ribs (HP:0000878)3.05690850
15Abnormality of the anterior horn cell (HP:0006802)3.03028198
16Degeneration of anterior horn cells (HP:0002398)3.03028198
17Progressive external ophthalmoplegia (HP:0000590)2.89031670
18Basal cell carcinoma (HP:0002671)2.82221224
19Chromsome breakage (HP:0040012)2.81686134
20Agnosia (HP:0010524)2.77443656
21Microvesicular hepatic steatosis (HP:0001414)2.77272512
22Breast hypoplasia (HP:0003187)2.73411536
23IgM deficiency (HP:0002850)2.70273621
24Myelodysplasia (HP:0002863)2.68343964
25Progressive muscle weakness (HP:0003323)2.66907134
26Hyperacusis (HP:0010780)2.65497791
27Absent thumb (HP:0009777)2.60514786
28Amaurosis fugax (HP:0100576)2.56476409
29Abnormality of chromosome stability (HP:0003220)2.52322583
30Deep philtrum (HP:0002002)2.47861972
31Patellar aplasia (HP:0006443)2.43498667
32Neoplasm of the pancreas (HP:0002894)2.42852067
33Ankyloglossia (HP:0010296)2.42827887
34Rhabdomyosarcoma (HP:0002859)2.42449068
35Deviation of the thumb (HP:0009603)2.39832850
36Proximal placement of thumb (HP:0009623)2.39538486
37Carpal bone hypoplasia (HP:0001498)2.38490498
38Missing ribs (HP:0000921)2.35368755
39Asymmetry of the thorax (HP:0001555)2.31792698
40Rough bone trabeculation (HP:0100670)2.31433448
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30925753
42Microretrognathia (HP:0000308)2.30867410
43Aplasia/Hypoplasia of the patella (HP:0006498)2.30280980
44Abnormality of the preputium (HP:0100587)2.30070927
45Dysmetric saccades (HP:0000641)2.29138172
46Nephroblastoma (Wilms tumor) (HP:0002667)2.27979705
47Lymphoma (HP:0002665)2.27892736
48Abnormal number of incisors (HP:0011064)2.27212183
49Multiple enchondromatosis (HP:0005701)2.24196126
50High anterior hairline (HP:0009890)2.23733104
51Meckel diverticulum (HP:0002245)2.23637045
52Spinal cord lesions (HP:0100561)2.22491166
53Syringomyelia (HP:0003396)2.22491166
54Increased nuchal translucency (HP:0010880)2.20800506
55Trismus (HP:0000211)2.19626879
56Deep palmar crease (HP:0006191)2.19063913
57Abnormality of cochlea (HP:0000375)2.17001616
58Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.16169729
59Premature graying of hair (HP:0002216)2.11865354
60Insomnia (HP:0100785)2.11351074
61Abnormality of the ileum (HP:0001549)2.10782801
62Atresia of the external auditory canal (HP:0000413)2.08655316
63Embryonal renal neoplasm (HP:0011794)2.06698842
64Cortical dysplasia (HP:0002539)2.05480449
65Flat acetabular roof (HP:0003180)2.04844732
66Broad distal phalanx of finger (HP:0009836)2.04075098
67Abnormality of reticulocytes (HP:0004312)2.01154585
68Abnormality of T cells (HP:0002843)2.00733270
69Bone marrow hypocellularity (HP:0005528)2.00390206
70Poikiloderma (HP:0001029)1.99789861
71Neoplasm of the colon (HP:0100273)1.99392603
72Biliary tract neoplasm (HP:0100574)1.98292769
73Diastasis recti (HP:0001540)1.97273065
74Squamous cell carcinoma (HP:0002860)1.97262601
75Aplasia/Hypoplasia of the uvula (HP:0010293)1.96446585
76Neoplasm of the oral cavity (HP:0100649)1.96316286
77Duodenal stenosis (HP:0100867)1.95851809
78Small intestinal stenosis (HP:0012848)1.95851809
79Abnormality of the calcaneus (HP:0008364)1.94064298
80Abnormality of oral frenula (HP:0000190)1.92644161
81Optic nerve coloboma (HP:0000588)1.92150361
82Abnormality of T cell physiology (HP:0011840)1.92137996
83Asplenia (HP:0001746)1.92032593
84Duplication of thumb phalanx (HP:0009942)1.91529459
85Cellular immunodeficiency (HP:0005374)1.91484401
86Glossoptosis (HP:0000162)1.90308382
87Prominent nose (HP:0000448)1.90225914
88Rectal prolapse (HP:0002035)1.90035362
89Astrocytoma (HP:0009592)1.89981875
90Abnormality of the astrocytes (HP:0100707)1.89981875
91Recurrent bronchitis (HP:0002837)1.86772514
92High pitched voice (HP:0001620)1.86625729
93Short middle phalanx of the 5th finger (HP:0004220)1.85509918
94Volvulus (HP:0002580)1.85224620
95Premature ovarian failure (HP:0008209)1.85195551
96Tracheoesophageal fistula (HP:0002575)1.84622877
97Overlapping toe (HP:0001845)1.84051834
98Acute myeloid leukemia (HP:0004808)1.83633020
99Septate vagina (HP:0001153)1.83199522
100Sloping forehead (HP:0000340)1.82503943
101Abnormality of the fingertips (HP:0001211)1.81961574
102Glioma (HP:0009733)1.81622913
103Overriding aorta (HP:0002623)1.80619096
104Abnormality of the thoracic spine (HP:0100711)1.80458721
105Calcaneovalgus deformity (HP:0001848)1.80305133
106Sandal gap (HP:0001852)1.79929376
107Aplasia/Hypoplasia of the sacrum (HP:0008517)1.79817270
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.78419821
109Self-mutilation (HP:0000742)1.77427892
110Abnormality of DNA repair (HP:0003254)1.77358375
111Neoplasm of striated muscle (HP:0009728)1.76851805
112Cutaneous melanoma (HP:0012056)1.75475326
113Ovarian neoplasm (HP:0100615)1.74938017
114Broad palm (HP:0001169)1.74440413
115Long palpebral fissure (HP:0000637)1.74386713
116Slender long bone (HP:0003100)1.73857659
117Vertebral arch anomaly (HP:0008438)1.73342863
118Ectopic kidney (HP:0000086)1.71938900
119Pseudobulbar signs (HP:0002200)1.71787015
120Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.71568062
121Short 4th metacarpal (HP:0010044)1.71568062
122T lymphocytopenia (HP:0005403)1.71545172
123Pancytopenia (HP:0001876)1.71399073
124Cafe-au-lait spot (HP:0000957)1.71028691
125Recurrent viral infections (HP:0004429)1.70862253
126Thoracic kyphosis (HP:0002942)1.69310076
127Acute lymphatic leukemia (HP:0006721)1.67513665
128Flared metaphyses (HP:0003015)1.66866334
129Abnormal lung lobation (HP:0002101)1.66205520
130Chronic otitis media (HP:0000389)1.65130787
131Neoplasm of the rectum (HP:0100743)1.64775978
132Entropion (HP:0000621)1.64604258
133Gastrointestinal carcinoma (HP:0002672)1.64189532
134Malignant gastrointestinal tract tumors (HP:0006749)1.64189532
135Renal duplication (HP:0000075)1.64031348
136Urethral obstruction (HP:0000796)1.62835016
137Elfin facies (HP:0004428)1.62747060
138Pointed chin (HP:0000307)1.62719491
139Impulsivity (HP:0100710)1.62673843
140Abnormality of B cell number (HP:0010975)1.62108252
141B lymphocytopenia (HP:0010976)1.62108252
142Horseshoe kidney (HP:0000085)1.62068443
143Disproportionate tall stature (HP:0001519)1.61894385
144Petechiae (HP:0000967)1.61716041
145Abnormality of the duodenum (HP:0002246)1.61453206
146Abnormality of the carotid arteries (HP:0005344)1.61312814
147Choanal atresia (HP:0000453)1.60463066
148Metaphyseal cupping (HP:0003021)1.59454159
149Obsessive-compulsive behavior (HP:0000722)1.59322198
150Triphalangeal thumb (HP:0001199)1.58731786
151Sparse lateral eyebrow (HP:0005338)1.57874749
152Truncus arteriosus (HP:0001660)1.56505349
153Embryonal neoplasm (HP:0002898)1.56389748
154Abnormality of the distal phalanx of the thumb (HP:0009617)1.55462801
155Premature skin wrinkling (HP:0100678)1.55381774
156Colitis (HP:0002583)1.54678352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.72397883
2WEE13.64480791
3SMG13.24600322
4BUB13.18749576
5EEF2K3.13918814
6PASK2.81261832
7TSSK62.63567971
8NEK22.55113543
9NME22.51879569
10EIF2AK12.36657745
11RPS6KB22.36264909
12PRPF4B2.34662889
13TGFBR12.23292322
14PKN21.98785632
15MAP4K11.94888537
16ACVR1B1.93527737
17ICK1.92845214
18SRPK11.83495503
19FLT31.80156670
20BRSK21.79024147
21NEK11.77413868
22TTK1.72549317
23RPS6KA41.70627866
24ATR1.68135860
25PBK1.67032369
26CDK121.66418583
27MKNK11.64099641
28SCYL21.63125150
29MAP3K101.57842390
30CDK71.57520171
31PLK11.53822304
32EIF2AK31.53493450
33AURKB1.51964389
34STK101.50538202
35TESK21.43965462
36LRRK21.43023549
37CDK41.41690473
38DYRK31.37375694
39MAP3K81.31800500
40VRK11.26163587
41KSR21.22371390
42STK161.22169581
43PLK41.21055140
44PAK41.21006844
45PLK31.17892336
46TAF11.16090866
47TLK11.14522760
48BTK1.09544064
49CHEK11.09527721
50MAP2K31.07816635
51ZAP701.03154103
52PIM11.02975475
53IRAK31.02746727
54PIM21.02108220
55EPHA21.01477150
56BRAF1.01151110
57CHEK20.98619839
58CDK190.97468823
59STK40.96682865
60JAK30.93777989
61MAPKAPK30.92252048
62FGFR40.91363404
63BRSK10.91179669
64ALK0.89955410
65MKNK20.89857377
66TEC0.88758809
67AURKA0.86628426
68BRD40.85356172
69CDK60.85024128
70ATM0.80429195
71PDGFRA0.78291281
72LATS10.77688048
73CDK20.74794897
74TRIB30.73831524
75MAP3K130.73728961
76LATS20.72657021
77CSNK2A20.70340275
78CLK10.69641784
79CCNB10.67767574
80KIT0.67345186
81SIK10.66480189
82CDK80.62847865
83KDR0.59801352
84GRK60.58785573
85TESK10.58611679
86RAF10.58460229
87STK240.57787114
88ILK0.56527962
89CSNK2A10.56272540
90NEK90.55682003
91CSF1R0.53904524
92PAK20.53417566
93MST40.52722118
94TYRO30.52702807
95AKT20.51558266
96ITK0.49926914
97PAK10.48692781
98MAPK110.48188946
99MAP3K90.47884993
100RPS6KC10.47193937
101RPS6KL10.47193937
102MELK0.47071328
103CDK10.45606831
104PRKCI0.45215924
105MAP3K30.44497818
106TXK0.44225163
107MTOR0.44119309
108TAOK20.43846721
109TYK20.43259309
110MAP2K20.41328594
111BMPR20.40392864
112VRK20.39635480
113MAP3K110.39356686
114NLK0.39156241
115RPS6KA60.39069574
116ZAK0.38841188
117PTK60.38437728
118MAP3K140.38434750
119CHUK0.38428466
120CDK90.38063962
121YES10.37179656
122STK30.36987634
123CAMK1D0.36947780
124MST1R0.36499382
125RPS6KA50.36337870
126FGFR10.35494064
127RPS6KA10.35145064
128BCKDK0.35130406
129NEK60.35005236
130IKBKB0.34292310
131PDK20.33994151
132KSR10.33762517
133LCK0.33032749
134SYK0.31299230
135PRKDC0.30158556
136EIF2AK20.29711169
137RPS6KB10.29183567
138BLK0.28127278

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.91975162
2Mismatch repair_Homo sapiens_hsa034304.16719782
3* Ribosome_Homo sapiens_hsa030104.14775354
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.21521571
5Spliceosome_Homo sapiens_hsa030403.12866507
6Base excision repair_Homo sapiens_hsa034103.02004805
7RNA transport_Homo sapiens_hsa030132.92656679
8Homologous recombination_Homo sapiens_hsa034402.72835478
9Nucleotide excision repair_Homo sapiens_hsa034202.71570099
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.66364928
11One carbon pool by folate_Homo sapiens_hsa006702.63773512
12Proteasome_Homo sapiens_hsa030502.60568551
13Cell cycle_Homo sapiens_hsa041102.53110981
14RNA polymerase_Homo sapiens_hsa030202.47890980
15Non-homologous end-joining_Homo sapiens_hsa034502.18930049
16Pyrimidine metabolism_Homo sapiens_hsa002402.11365972
17Fanconi anemia pathway_Homo sapiens_hsa034601.83462986
18RNA degradation_Homo sapiens_hsa030181.79449517
19mRNA surveillance pathway_Homo sapiens_hsa030151.63963203
20p53 signaling pathway_Homo sapiens_hsa041151.55673761
21Basal transcription factors_Homo sapiens_hsa030221.50415930
22Antigen processing and presentation_Homo sapiens_hsa046121.43826671
23Primary immunodeficiency_Homo sapiens_hsa053401.29050189
24Herpes simplex infection_Homo sapiens_hsa051681.22053231
25Epstein-Barr virus infection_Homo sapiens_hsa051691.21912285
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10154298
27Purine metabolism_Homo sapiens_hsa002301.03907462
28Viral carcinogenesis_Homo sapiens_hsa052031.03897165
29Lysine degradation_Homo sapiens_hsa003100.98038017
30HTLV-I infection_Homo sapiens_hsa051660.94995849
31Systemic lupus erythematosus_Homo sapiens_hsa053220.90053360
32Endometrial cancer_Homo sapiens_hsa052130.89947044
33Thyroid cancer_Homo sapiens_hsa052160.89680079
34Legionellosis_Homo sapiens_hsa051340.88422056
35Selenocompound metabolism_Homo sapiens_hsa004500.85617161
36Cyanoamino acid metabolism_Homo sapiens_hsa004600.85470041
37Pentose phosphate pathway_Homo sapiens_hsa000300.84620787
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82554116
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79855740
40Small cell lung cancer_Homo sapiens_hsa052220.79061738
41Measles_Homo sapiens_hsa051620.77885342
42Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77608801
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76992799
44Glioma_Homo sapiens_hsa052140.74220715
45Biosynthesis of amino acids_Homo sapiens_hsa012300.73186302
46ErbB signaling pathway_Homo sapiens_hsa040120.73173611
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72011536
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72008081
49Renal cell carcinoma_Homo sapiens_hsa052110.71116663
50Pyruvate metabolism_Homo sapiens_hsa006200.71104959
51VEGF signaling pathway_Homo sapiens_hsa043700.71013545
52Longevity regulating pathway - mammal_Homo sapiens_hsa042110.70059270
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.68364916
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68096471
55Protein export_Homo sapiens_hsa030600.67447500
56N-Glycan biosynthesis_Homo sapiens_hsa005100.64664483
57Oocyte meiosis_Homo sapiens_hsa041140.64075334
58Chronic myeloid leukemia_Homo sapiens_hsa052200.63307554
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.63096964
60MicroRNAs in cancer_Homo sapiens_hsa052060.63046063
61Apoptosis_Homo sapiens_hsa042100.62180469
62Sulfur relay system_Homo sapiens_hsa041220.62018188
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.60750836
64Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58713784
65Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57905661
66Fructose and mannose metabolism_Homo sapiens_hsa000510.57177022
67Hepatitis B_Homo sapiens_hsa051610.56783409
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.55826006
69Acute myeloid leukemia_Homo sapiens_hsa052210.54931197
70Insulin signaling pathway_Homo sapiens_hsa049100.54563782
71Hematopoietic cell lineage_Homo sapiens_hsa046400.54336379
72Shigellosis_Homo sapiens_hsa051310.52841141
73Colorectal cancer_Homo sapiens_hsa052100.51892272
74Folate biosynthesis_Homo sapiens_hsa007900.49547859
75Inositol phosphate metabolism_Homo sapiens_hsa005620.48397022
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48331017
77Notch signaling pathway_Homo sapiens_hsa043300.47370372
78Influenza A_Homo sapiens_hsa051640.46173500
79Wnt signaling pathway_Homo sapiens_hsa043100.45355604
80B cell receptor signaling pathway_Homo sapiens_hsa046620.44931939
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44737587
82AMPK signaling pathway_Homo sapiens_hsa041520.44470043
83Viral myocarditis_Homo sapiens_hsa054160.43643835
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43429424
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42590592
86Melanoma_Homo sapiens_hsa052180.42580375
87Vitamin B6 metabolism_Homo sapiens_hsa007500.42305070
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.42068373
89Leishmaniasis_Homo sapiens_hsa051400.41692266
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40983658
91HIF-1 signaling pathway_Homo sapiens_hsa040660.40934688
92Choline metabolism in cancer_Homo sapiens_hsa052310.40845195
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.40360243
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.40345087
95TGF-beta signaling pathway_Homo sapiens_hsa043500.39927769
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.39716673
97Carbon metabolism_Homo sapiens_hsa012000.39253759
98T cell receptor signaling pathway_Homo sapiens_hsa046600.38872292
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.37466842
100Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37352547
101Bladder cancer_Homo sapiens_hsa052190.36476870
102Prolactin signaling pathway_Homo sapiens_hsa049170.36451897
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.34026595
104Galactose metabolism_Homo sapiens_hsa000520.33424039
105Pathways in cancer_Homo sapiens_hsa052000.33187902
106FoxO signaling pathway_Homo sapiens_hsa040680.32872877
107Non-small cell lung cancer_Homo sapiens_hsa052230.32794241
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.32646632
109Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32052579
110Hippo signaling pathway_Homo sapiens_hsa043900.32010244
111Basal cell carcinoma_Homo sapiens_hsa052170.31980475
112Toxoplasmosis_Homo sapiens_hsa051450.31837137
113Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31491947
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.31246931
115Glutathione metabolism_Homo sapiens_hsa004800.31067645
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28713122
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28215121
1182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27524255
119Pancreatic cancer_Homo sapiens_hsa052120.25446719
120Adherens junction_Homo sapiens_hsa045200.25130279
121mTOR signaling pathway_Homo sapiens_hsa041500.24784850
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23732741
123Allograft rejection_Homo sapiens_hsa053300.22965066
124Prostate cancer_Homo sapiens_hsa052150.22619158
125Alcoholism_Homo sapiens_hsa050340.22066209
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.19894092
127Proteoglycans in cancer_Homo sapiens_hsa052050.19344947

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