RPL41

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.39757075
2ribosomal small subunit assembly (GO:0000028)8.00221139
3ATP synthesis coupled proton transport (GO:0015986)7.46597336
4energy coupled proton transport, down electrochemical gradient (GO:0015985)7.46597336
5* viral transcription (GO:0019083)7.34763832
6* translational termination (GO:0006415)7.10075015
7ribosomal small subunit biogenesis (GO:0042274)6.80904002
8* translational elongation (GO:0006414)6.24712472
9* SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.13907478
10maturation of SSU-rRNA (GO:0030490)6.13772745
11* protein targeting to ER (GO:0045047)5.98641811
12* cotranslational protein targeting to membrane (GO:0006613)5.97722652
13establishment of protein localization to mitochondrial membrane (GO:0090151)5.74480793
14* establishment of protein localization to endoplasmic reticulum (GO:0072599)5.70128560
15* nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.64506093
16* translational initiation (GO:0006413)5.63387534
17* protein localization to endoplasmic reticulum (GO:0070972)5.59746398
18* cellular protein complex disassembly (GO:0043624)5.55243019
19chaperone-mediated protein transport (GO:0072321)5.53451217
20* viral life cycle (GO:0019058)5.51634882
21respiratory electron transport chain (GO:0022904)5.37309078
22ribosomal large subunit biogenesis (GO:0042273)5.30564733
23electron transport chain (GO:0022900)5.27753276
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.24754556
25* protein complex disassembly (GO:0043241)4.93403460
26DNA deamination (GO:0045006)4.77438787
27* macromolecular complex disassembly (GO:0032984)4.62280045
28ribonucleoprotein complex biogenesis (GO:0022613)4.55333306
29formation of translation preinitiation complex (GO:0001731)4.41822343
30* translation (GO:0006412)4.33993023
31* nuclear-transcribed mRNA catabolic process (GO:0000956)4.17869528
32inner mitochondrial membrane organization (GO:0007007)4.17624815
33ATP biosynthetic process (GO:0006754)3.99914967
34DNA strand elongation involved in DNA replication (GO:0006271)3.98175523
35* mRNA catabolic process (GO:0006402)3.95732427
36* protein targeting (GO:0006605)3.94981348
37protein complex biogenesis (GO:0070271)3.94254234
38* protein targeting to membrane (GO:0006612)3.93836206
39telomere maintenance via semi-conservative replication (GO:0032201)3.88596192
40mitochondrial respiratory chain complex assembly (GO:0033108)3.82294745
41rRNA processing (GO:0006364)3.79984768
42DNA strand elongation (GO:0022616)3.77996753
43sequestering of actin monomers (GO:0042989)3.77452477
44* RNA catabolic process (GO:0006401)3.77076631
45protein neddylation (GO:0045116)3.73741566
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.72179511
47mitochondrial respiratory chain complex I assembly (GO:0032981)3.72179511
48NADH dehydrogenase complex assembly (GO:0010257)3.72179511
49purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.66667620
50rRNA metabolic process (GO:0016072)3.66218224
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.65713533
52nucleobase biosynthetic process (GO:0046112)3.53512505
53DNA replication initiation (GO:0006270)3.52573751
54hydrogen ion transmembrane transport (GO:1902600)3.51756329
55ribosome assembly (GO:0042255)3.49667594
56ribosome biogenesis (GO:0042254)3.48727014
57spliceosomal snRNP assembly (GO:0000387)3.48354641
58protein localization to kinetochore (GO:0034501)3.45243057
59telomere maintenance via recombination (GO:0000722)3.44676086
60* protein localization to membrane (GO:0072657)3.43880017
61DNA replication checkpoint (GO:0000076)3.43339443
62cellular component biogenesis (GO:0044085)3.42988197
63mitotic metaphase plate congression (GO:0007080)3.36262927
64purine nucleobase biosynthetic process (GO:0009113)3.35138035
65deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.33906746
66ribonucleoside triphosphate biosynthetic process (GO:0009201)3.33491969
67mitotic recombination (GO:0006312)3.24569080
68chromatin remodeling at centromere (GO:0031055)3.23178356
69regulation of mitochondrial translation (GO:0070129)3.22953248
70CENP-A containing nucleosome assembly (GO:0034080)3.22399677
71spliceosomal complex assembly (GO:0000245)3.21951660
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18689261
73proteasome assembly (GO:0043248)3.18425199
74DNA unwinding involved in DNA replication (GO:0006268)3.18286217
75transcription elongation from RNA polymerase III promoter (GO:0006385)3.17754126
76termination of RNA polymerase III transcription (GO:0006386)3.17754126
77oxidative phosphorylation (GO:0006119)3.17660588
78kinetochore organization (GO:0051383)3.13219105
79kinetochore assembly (GO:0051382)3.11835245
80negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.10798617
81mitotic nuclear envelope disassembly (GO:0007077)3.10731799
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10244946
83telomere maintenance via telomere lengthening (GO:0010833)3.08164423
84pseudouridine synthesis (GO:0001522)3.07750676
85protein localization to chromosome, centromeric region (GO:0071459)3.06906256
86folic acid-containing compound biosynthetic process (GO:0009396)3.03858453
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.03024721
88rRNA modification (GO:0000154)3.01116959
89intracellular protein transmembrane import (GO:0044743)3.00711010
90proton transport (GO:0015992)3.00312717
91positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99143236
92IMP biosynthetic process (GO:0006188)2.99050376
93regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.98999126
94nucleoside triphosphate biosynthetic process (GO:0009142)2.95890737
95transcription-coupled nucleotide-excision repair (GO:0006283)2.94918242
96* protein localization to organelle (GO:0033365)2.93755391
97nucleotide-excision repair, DNA gap filling (GO:0006297)2.93517778
98DNA replication-dependent nucleosome assembly (GO:0006335)2.93512063
99DNA replication-dependent nucleosome organization (GO:0034723)2.93512063
100hydrogen transport (GO:0006818)2.93299420
101DNA replication-independent nucleosome organization (GO:0034724)2.92297650
102DNA replication-independent nucleosome assembly (GO:0006336)2.92297650
103negative regulation of ligase activity (GO:0051352)2.84775807
104negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.84775807
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.84725082
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.84725082
107metaphase plate congression (GO:0051310)2.83879788
108membrane disassembly (GO:0030397)2.82232366
109nuclear envelope disassembly (GO:0051081)2.82232366
110ncRNA 3-end processing (GO:0043628)2.80871061
111protein targeting to mitochondrion (GO:0006626)2.80518724
112establishment of protein localization to mitochondrion (GO:0072655)2.79060393
113establishment of integrated proviral latency (GO:0075713)2.78137303
114negative regulation of RNA splicing (GO:0033119)2.77475258
115exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72951344
116midbrain development (GO:0030901)2.72075455
117transcription from RNA polymerase I promoter (GO:0006360)2.71120542
1187-methylguanosine mRNA capping (GO:0006370)2.69699916
119DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.69651541
120* establishment of protein localization to membrane (GO:0090150)2.69347928
121regulation of spindle organization (GO:0090224)2.69183546
122protein localization to mitochondrion (GO:0070585)2.68524210
123ncRNA processing (GO:0034470)2.66314194
124intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.65568082
125signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.65568082
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65332131
127signal transduction involved in DNA damage checkpoint (GO:0072422)2.65332131
128signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.64576585
129signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.64576585
130signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.64576585
131aerobic respiration (GO:0009060)2.64492591
132termination of RNA polymerase I transcription (GO:0006363)2.64487351
133positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.63967422
134nucleobase-containing small molecule interconversion (GO:0015949)2.63865017
1357-methylguanosine RNA capping (GO:0009452)2.63029382
136RNA capping (GO:0036260)2.63029382
137otic vesicle formation (GO:0030916)2.62624914
138RNA splicing, via transesterification reactions (GO:0000375)2.62023360
139mitochondrial transport (GO:0006839)2.61672483
140GTP biosynthetic process (GO:0006183)2.61384353
141* establishment of protein localization to organelle (GO:0072594)2.61136505
142histone exchange (GO:0043486)2.56110264
143* cellular component disassembly (GO:0022411)2.55049575
144DNA damage response, detection of DNA damage (GO:0042769)2.49656548
145cytochrome complex assembly (GO:0017004)2.48942311

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.57151782
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47957577
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.10264035
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.27690773
5* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.25336584
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08076386
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.05570153
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.01292064
9* GABP_17652178_ChIP-ChIP_JURKAT_Human2.97451247
10* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.93536066
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.91744155
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85879921
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85140048
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82767298
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78423134
16* XRN2_22483619_ChIP-Seq_HELA_Human2.61610118
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.60141276
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37458119
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.25900809
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25317102
21* SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24506922
22* VDR_23849224_ChIP-Seq_CD4+_Human2.22436017
23NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.16264487
24DCP1A_22483619_ChIP-Seq_HELA_Human2.07120524
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05025834
26* TTF2_22483619_ChIP-Seq_HELA_Human1.95388105
27ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94146523
28FOXP3_21729870_ChIP-Seq_TREG_Human1.88295799
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86404432
30* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84813638
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83982532
32* GABP_19822575_ChIP-Seq_HepG2_Human1.82249064
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78764512
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71180846
35THAP11_20581084_ChIP-Seq_MESCs_Mouse1.68479290
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.68453225
37* ELK1_19687146_ChIP-ChIP_HELA_Human1.66364600
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64392598
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.62245675
40YY1_21170310_ChIP-Seq_MESCs_Mouse1.59388635
41AR_21909140_ChIP-Seq_LNCAP_Human1.57596918
42MYC_22102868_ChIP-Seq_BL_Human1.57373592
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56283073
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.55989086
45SOX2_16153702_ChIP-ChIP_HESCs_Human1.54887836
46CIITA_25753668_ChIP-Seq_RAJI_Human1.50531965
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50300751
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45069418
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.44062210
50E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.43949641
51* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.43924491
52POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43830521
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42447407
54TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42241317
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39445252
56FUS_26573619_Chip-Seq_HEK293_Human1.39129959
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37801894
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34470616
59KDM5A_27292631_Chip-Seq_BREAST_Human1.33437417
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33162907
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.32937970
62SRF_21415370_ChIP-Seq_HL-1_Mouse1.32750108
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31201111
64CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30369744
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29448275
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29144464
67VDR_21846776_ChIP-Seq_THP-1_Human1.27604561
68NANOG_16153702_ChIP-ChIP_HESCs_Human1.27272399
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.25419613
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.24596056
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.24016683
72* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22901747
73EWS_26573619_Chip-Seq_HEK293_Human1.21738885
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20470375
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19025575
76* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.18208092
77ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16433817
78* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16238113
79* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15889066
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10064411
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06690013
82HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.06649573
83* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.06367814
84TFEB_21752829_ChIP-Seq_HELA_Human1.06220660
85CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05011859
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.04534003
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.03512394
88* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01658915
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01350341
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97712346
91CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97436748
92* SPI1_23547873_ChIP-Seq_NB4_Human0.97243091
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96568065
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.95658773
95MYC_18940864_ChIP-ChIP_HL60_Human0.95303220
96OCT4_18692474_ChIP-Seq_MEFs_Mouse0.95006234
97ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94543641
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94023323
99PADI4_21655091_ChIP-ChIP_MCF-7_Human0.91138578
100* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90168387
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89032051
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88792902
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.88674649
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87861450
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87861450
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87861450
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.87831644
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87334058
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86408085
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85913597
111* SOX17_20123909_ChIP-Seq_XEN_Mouse0.85436484
112TCF3_18692474_ChIP-Seq_MEFs_Mouse0.85428887
113BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82271560
114* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80956302
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80425235
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80179574
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.79614617
118VDR_22108803_ChIP-Seq_LS180_Human0.79000510
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78429516
120* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.78023555
121ELF5_23300383_ChIP-Seq_T47D_Human0.76268389
122MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76202434
123ERG_20517297_ChIP-Seq_VCAP_Human0.74246819
124* FOXP1_21924763_ChIP-Seq_HESCs_Human0.67708103
125NANOG_21062744_ChIP-ChIP_HESCs_Human0.65665845

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.39160714
2MP0003136_yellow_coat_color4.50037753
3MP0004957_abnormal_blastocyst_morpholog4.10521365
4MP0003111_abnormal_nucleus_morphology3.66789275
5MP0000566_synostosis3.57052048
6MP0003077_abnormal_cell_cycle3.48400799
7MP0010094_abnormal_chromosome_stability3.35637877
8MP0006292_abnormal_olfactory_placode3.35122392
9MP0009379_abnormal_foot_pigmentation2.86560922
10MP0008007_abnormal_cellular_replicative2.47817698
11MP0008932_abnormal_embryonic_tissue2.45527214
12MP0003123_paternal_imprinting2.38101639
13MP0008058_abnormal_DNA_repair2.37690102
14MP0008057_abnormal_DNA_replication2.25484099
15MP0002277_abnormal_respiratory_mucosa2.20255444
16MP0010352_gastrointestinal_tract_polyps2.18571188
17MP0002396_abnormal_hematopoietic_system2.11688444
18MP0001346_abnormal_lacrimal_gland2.04429906
19MP0000490_abnormal_crypts_of2.00401647
20MP0001730_embryonic_growth_arrest1.99414453
21MP0000350_abnormal_cell_proliferation1.93306684
22MP0009333_abnormal_splenocyte_physiolog1.75526396
23MP0003786_premature_aging1.74720243
24MP0010030_abnormal_orbit_morphology1.74420145
25MP0003011_delayed_dark_adaptation1.69561931
26MP0003938_abnormal_ear_development1.64968864
27MP0002697_abnormal_eye_size1.64481113
28MP0001529_abnormal_vocalization1.63505924
29MP0008995_early_reproductive_senescence1.62971738
30MP0002653_abnormal_ependyma_morphology1.61570289
31MP0006054_spinal_hemorrhage1.61141091
32MP0006072_abnormal_retinal_apoptosis1.59189437
33MP0001286_abnormal_eye_development1.57783885
34MP0004808_abnormal_hematopoietic_stem1.52101314
35MP0003283_abnormal_digestive_organ1.50907346
36MP0008789_abnormal_olfactory_epithelium1.50067838
37MP0000631_abnormal_neuroendocrine_gland1.47630699
38MP0002638_abnormal_pupillary_reflex1.47184687
39MP0001697_abnormal_embryo_size1.46190908
40MP0003567_abnormal_fetal_cardiomyocyte1.45985722
41MP0005380_embryogenesis_phenotype1.43998324
42MP0001672_abnormal_embryogenesis/_devel1.43998324
43MP0003718_maternal_effect1.43661223
44MP0000313_abnormal_cell_death1.42357438
45MP0010307_abnormal_tumor_latency1.41980704
46MP0001485_abnormal_pinna_reflex1.40760445
47MP0002080_prenatal_lethality1.40325468
48MP0001545_abnormal_hematopoietic_system1.36374456
49MP0005397_hematopoietic_system_phenotyp1.36374456
50MP0003315_abnormal_perineum_morphology1.35437962
51MP0003186_abnormal_redox_activity1.32078978
52MP0005377_hearing/vestibular/ear_phenot1.31293854
53MP0003878_abnormal_ear_physiology1.31293854
54MP0003984_embryonic_growth_retardation1.31199263
55MP0002019_abnormal_tumor_incidence1.30422715
56MP0002234_abnormal_pharynx_morphology1.29934783
57MP0002132_abnormal_respiratory_system1.28683614
58MP0003890_abnormal_embryonic-extraembry1.28556381
59MP0002088_abnormal_embryonic_growth/wei1.28416915
60MP0002085_abnormal_embryonic_tissue1.24341834
61MP0000372_irregular_coat_pigmentation1.22461339
62MP0004142_abnormal_muscle_tone1.21486416
63MP0000858_altered_metastatic_potential1.19000741
64MP0002282_abnormal_trachea_morphology1.17885787
65MP0002086_abnormal_extraembryonic_tissu1.17653170
66MP0002233_abnormal_nose_morphology1.15102710
67MP0004197_abnormal_fetal_growth/weight/1.13893007
68MP0005084_abnormal_gallbladder_morpholo1.13137419
69MP0003941_abnormal_skin_development1.11703780
70MP0009053_abnormal_anal_canal1.09377280
71MP0002084_abnormal_developmental_patter1.08782964
72MP0000750_abnormal_muscle_regeneration1.07781849
73MP0005076_abnormal_cell_differentiation1.07276475
74MP0005499_abnormal_olfactory_system1.07066190
75MP0005394_taste/olfaction_phenotype1.07066190
76MP0002249_abnormal_larynx_morphology1.05859459
77MP0000026_abnormal_inner_ear1.05388998
78MP0000579_abnormal_nail_morphology1.05352110
79MP0001293_anophthalmia1.04526112
80MP0002722_abnormal_immune_system1.03959640
81MP0000703_abnormal_thymus_morphology1.03778281
82MP0000762_abnormal_tongue_morphology1.03143344
83MP0002398_abnormal_bone_marrow1.00515788
84MP0000537_abnormal_urethra_morphology1.00319050
85MP0003763_abnormal_thymus_physiology0.99391942
86MP0005023_abnormal_wound_healing0.96642930
87MP0009250_abnormal_appendicular_skeleto0.95412827
88MP0005391_vision/eye_phenotype0.95039574
89MP0003119_abnormal_digestive_system0.94779120
90MP0002092_abnormal_eye_morphology0.93154407
91MP0000358_abnormal_cell_content/0.91646973
92MP0003755_abnormal_palate_morphology0.90849098
93MP0003806_abnormal_nucleotide_metabolis0.89513722
94MP0003705_abnormal_hypodermis_morpholog0.89286762
95MP0000689_abnormal_spleen_morphology0.89257330
96MP0003880_abnormal_central_pattern0.88418408
97MP0002429_abnormal_blood_cell0.86573891
98MP0002111_abnormal_tail_morphology0.86252661
99MP0002938_white_spotting0.85978082
100MP0000477_abnormal_intestine_morphology0.83195447
101MP0002751_abnormal_autonomic_nervous0.80609083
102MP0000685_abnormal_immune_system0.80416228
103MP0003942_abnormal_urinary_system0.79892198
104MP0001835_abnormal_antigen_presentation0.77648526
105MP0005075_abnormal_melanosome_morpholog0.77492113
106MP0001853_heart_inflammation0.76174362
107MP0002160_abnormal_reproductive_system0.76055955
108MP0010155_abnormal_intestine_physiology0.75598706
109MP0000428_abnormal_craniofacial_morphol0.74561410
110MP0002102_abnormal_ear_morphology0.74470305
111MP0000778_abnormal_nervous_system0.73780241
112MP0000049_abnormal_middle_ear0.73151707
113MP0009697_abnormal_copulation0.73018070
114MP0001849_ear_inflammation0.72560261
115MP0005195_abnormal_posterior_eye0.72366360
116MP0000678_abnormal_parathyroid_gland0.72112007
117MP0005389_reproductive_system_phenotype0.71801045
118MP0000716_abnormal_immune_system0.71760799
119MP0003861_abnormal_nervous_system0.71617017
120MP0005253_abnormal_eye_physiology0.71382019
121MP0002210_abnormal_sex_determination0.71293958
122MP0004133_heterotaxia0.70637589
123MP0004742_abnormal_vestibular_system0.70383357
124MP0002736_abnormal_nociception_after0.70373965
125MP0006035_abnormal_mitochondrial_morpho0.70209747
126MP0001881_abnormal_mammary_gland0.69006248
127MP0003566_abnormal_cell_adhesion0.68630563
128MP0002405_respiratory_system_inflammati0.68376290
129MP0009278_abnormal_bone_marrow0.67524757
130MP0003936_abnormal_reproductive_system0.66846997
131MP0001324_abnormal_eye_pigmentation0.66826169
132MP0005501_abnormal_skin_physiology0.66587873
133MP0003436_decreased_susceptibility_to0.66531089
134MP0001145_abnormal_male_reproductive0.66420646
135MP0005384_cellular_phenotype0.66370217
136MP0000733_abnormal_muscle_development0.66041487
137MP0003121_genomic_imprinting0.65173442
138MP0000653_abnormal_sex_gland0.64645051
139MP0002932_abnormal_joint_morphology0.63963668
140MP0002452_abnormal_antigen_presenting0.63559775
141MP0008877_abnormal_DNA_methylation0.63441054
142MP0003937_abnormal_limbs/digits/tail_de0.62135770
143MP0002420_abnormal_adaptive_immunity0.61629924
144MP0002116_abnormal_craniofacial_bone0.61528830
145MP0001819_abnormal_immune_cell0.61436949
146MP0005621_abnormal_cell_physiology0.60426163
147MP0002109_abnormal_limb_morphology0.60174660
148MP0001929_abnormal_gametogenesis0.59904214
149MP0002006_tumorigenesis0.59883026
150MP0002163_abnormal_gland_morphology0.59830521
151MP0005503_abnormal_tendon_morphology0.59646015
152MP0000647_abnormal_sebaceous_gland0.59424046
153MP0001800_abnormal_humoral_immune0.59373128
154MP0009672_abnormal_birth_weight0.58893492
155MP0005408_hypopigmentation0.58750469
156MP0002752_abnormal_somatic_nervous0.58592085
157MP0002095_abnormal_skin_pigmentation0.58255036
158MP0005174_abnormal_tail_pigmentation0.57720598
159MP0003448_altered_tumor_morphology0.57687834
160MP0002928_abnormal_bile_duct0.56214931
161MP0006036_abnormal_mitochondrial_physio0.55804356

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)7.12904639
2Reticulocytopenia (HP:0001896)6.95127329
3Abnormal number of erythroid precursors (HP:0012131)6.60706500
4Macrocytic anemia (HP:0001972)4.99252961
5Pallor (HP:0000980)4.62841794
6Abnormal mitochondria in muscle tissue (HP:0008316)4.44995330
7Acute encephalopathy (HP:0006846)4.24356853
8Progressive macrocephaly (HP:0004481)4.06269309
9Renal Fanconi syndrome (HP:0001994)3.82211373
10Septo-optic dysplasia (HP:0100842)3.72705097
11Partial duplication of thumb phalanx (HP:0009944)3.59697727
12Colon cancer (HP:0003003)3.57222845
13Partial duplication of the phalanx of hand (HP:0009999)3.53953235
14Birth length less than 3rd percentile (HP:0003561)3.51177032
15Aplasia/Hypoplasia of the sacrum (HP:0008517)3.42010029
16Thrombocytosis (HP:0001894)3.40189130
17Multiple enchondromatosis (HP:0005701)3.39074651
18Aplastic anemia (HP:0001915)3.37852631
19Oral leukoplakia (HP:0002745)3.28256685
20Trismus (HP:0000211)3.24048317
21Selective tooth agenesis (HP:0001592)3.17682311
22Carpal bone hypoplasia (HP:0001498)3.16500372
23Rough bone trabeculation (HP:0100670)3.16380541
24Breast hypoplasia (HP:0003187)3.15418830
25Cerebral edema (HP:0002181)3.12326688
2611 pairs of ribs (HP:0000878)3.04179659
27Increased intramyocellular lipid droplets (HP:0012240)3.01598399
28Respiratory difficulties (HP:0002880)2.93915385
293-Methylglutaconic aciduria (HP:0003535)2.91236894
30Abnormality of the parietal bone (HP:0002696)2.84613751
31Microretrognathia (HP:0000308)2.77112330
32Patellar aplasia (HP:0006443)2.76230657
33Absent thumb (HP:0009777)2.73995315
34Abnormality of reticulocytes (HP:0004312)2.69020381
35Aplasia/Hypoplasia of the patella (HP:0006498)2.66931054
36Absent septum pellucidum (HP:0001331)2.66208056
37Maternal diabetes (HP:0009800)2.63600722
38Degeneration of anterior horn cells (HP:0002398)2.57824654
39Abnormality of the anterior horn cell (HP:0006802)2.57824654
40Duplication of thumb phalanx (HP:0009942)2.52321517
41Abnormality of renal resorption (HP:0011038)2.48153285
42Abnormal hemoglobin (HP:0011902)2.45687108
43Esophageal atresia (HP:0002032)2.42090570
44Leukodystrophy (HP:0002415)2.40517513
45Increased muscle lipid content (HP:0009058)2.39855503
46Rib fusion (HP:0000902)2.37033923
47Bilateral microphthalmos (HP:0007633)2.36622173
48Optic disc pallor (HP:0000543)2.34780328
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34299571
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34299571
51Concave nail (HP:0001598)2.30189931
52Abnormal trabecular bone morphology (HP:0100671)2.30011231
53Abnormality of the septum pellucidum (HP:0007375)2.29386316
54Neoplasm of the pancreas (HP:0002894)2.28033583
55Nasolacrimal duct obstruction (HP:0000579)2.27556426
56Exercise intolerance (HP:0003546)2.26826759
57Respiratory failure (HP:0002878)2.26804074
58Glossoptosis (HP:0000162)2.23025122
59Secondary amenorrhea (HP:0000869)2.21815017
60Pancreatic cysts (HP:0001737)2.21778193
61Meckel diverticulum (HP:0002245)2.21756572
62Cerebral hypomyelination (HP:0006808)2.20565723
63Pancreatic fibrosis (HP:0100732)2.20189149
64Premature graying of hair (HP:0002216)2.19124999
65Missing ribs (HP:0000921)2.18122625
66Anophthalmia (HP:0000528)2.17368202
67Cleft eyelid (HP:0000625)2.17082672
68Atresia of the external auditory canal (HP:0000413)2.15687938
69Depressed nasal ridge (HP:0000457)2.15628806
70Woolly hair (HP:0002224)2.15413774
71Lactic acidosis (HP:0003128)2.14927393
72Hyperphosphaturia (HP:0003109)2.13016200
73Hypoplasia of the radius (HP:0002984)2.11386263
74Abnormality of the lacrimal duct (HP:0011481)2.09515278
75Triphalangeal thumb (HP:0001199)2.07403127
76Abnormality of the preputium (HP:0100587)2.06898140
77Myelodysplasia (HP:0002863)2.06134031
78Abnormality of the ileum (HP:0001549)2.05367091
79True hermaphroditism (HP:0010459)2.02261880
80Cellular immunodeficiency (HP:0005374)2.01514602
81Hypoplasia of the pons (HP:0012110)2.01276083
82Poor head control (HP:0002421)2.01177324
83Horseshoe kidney (HP:0000085)2.00718819
84Abnormality of the pons (HP:0007361)2.00443026
85Premature ovarian failure (HP:0008209)1.99983766
86Chromsome breakage (HP:0040012)1.99363685
87Tracheoesophageal fistula (HP:0002575)1.97772829
88Increased hepatocellular lipid droplets (HP:0006565)1.97000942
89Abnormality of the nasolacrimal system (HP:0000614)1.96652670
90Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.96422334
91Exertional dyspnea (HP:0002875)1.92695177
92Abnormality of urine glucose concentration (HP:0011016)1.92676280
93Glycosuria (HP:0003076)1.92676280
94Abnormality of chromosome stability (HP:0003220)1.90066611
95Abnormal number of incisors (HP:0011064)1.89590082
96Sparse eyelashes (HP:0000653)1.89229593
97Stenosis of the external auditory canal (HP:0000402)1.89080584
98Thick lower lip vermilion (HP:0000179)1.88546732
99Molar tooth sign on MRI (HP:0002419)1.87812741
100Abnormality of midbrain morphology (HP:0002418)1.87812741
101Abnormality of the labia minora (HP:0012880)1.87285737
102Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86994791
103Impulsivity (HP:0100710)1.86173943
104Abnormality of the umbilical cord (HP:0010881)1.85734410
105Congenital, generalized hypertrichosis (HP:0004540)1.84725721
106Bone marrow hypocellularity (HP:0005528)1.83848319
107Abnormality of the phalanges of the 2nd finger (HP:0009541)1.82910650
108Absent radius (HP:0003974)1.82142043
109Abnormality of the heme biosynthetic pathway (HP:0010472)1.81554330
110Mitochondrial inheritance (HP:0001427)1.81056190
111Sclerocornea (HP:0000647)1.80929584
112Optic nerve hypoplasia (HP:0000609)1.80876379
113Hepatocellular necrosis (HP:0001404)1.77904369
114Petechiae (HP:0000967)1.75373844
115Abnormal respiratory motile cilium physiology (HP:0012261)1.73696927
116Abnormality of the fetal cardiovascular system (HP:0010948)1.72935919
117Abnormal umbilical cord blood vessels (HP:0011403)1.72935919
118Single umbilical artery (HP:0001195)1.72935919
119Abnormal ciliary motility (HP:0012262)1.72572865
120Medulloblastoma (HP:0002885)1.71684599
121Increased serum lactate (HP:0002151)1.71440731
122Small intestinal stenosis (HP:0012848)1.70853182
123Duodenal stenosis (HP:0100867)1.70853182
124Pancytopenia (HP:0001876)1.69857228
125Gastrointestinal atresia (HP:0002589)1.69831642
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69828319
127Type I transferrin isoform profile (HP:0003642)1.68875055
128Nephronophthisis (HP:0000090)1.68862313
129Lipid accumulation in hepatocytes (HP:0006561)1.68681791
130Duplicated collecting system (HP:0000081)1.67844918
131Slender long bone (HP:0003100)1.67425924
132Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66990420
133Megaloblastic anemia (HP:0001889)1.66687048
134Lethargy (HP:0001254)1.66439714
135IgM deficiency (HP:0002850)1.65517282
136Aplasia involving forearm bones (HP:0009822)1.65246789
137Absent forearm bone (HP:0003953)1.65246789
138Aplasia/Hypoplasia of the uvula (HP:0010293)1.65080308
139Hemivertebrae (HP:0002937)1.64735908
140Increased CSF lactate (HP:0002490)1.64503826
141Hyperglycinemia (HP:0002154)1.63791892
142Abdominal situs inversus (HP:0003363)1.63500766
143Abnormality of abdominal situs (HP:0011620)1.63500766
144Facial cleft (HP:0002006)1.62793812
145Hepatic necrosis (HP:0002605)1.61461770
146Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60034170
147Ankle contracture (HP:0006466)1.59646337
148Basal cell carcinoma (HP:0002671)1.59502776
149Renal tubular dysfunction (HP:0000124)1.59202365
150Microvesicular hepatic steatosis (HP:0001414)1.59110063
151Protrusio acetabuli (HP:0003179)1.58993605
152Short thumb (HP:0009778)1.58783811
153Progressive muscle weakness (HP:0003323)1.57697448
154Hypoplasia of the capital femoral epiphysis (HP:0003090)1.57531057
155Short middle phalanx of the 5th finger (HP:0004220)1.57266140
156Lymphoma (HP:0002665)1.55768542
157Acute necrotizing encephalopathy (HP:0006965)1.55618664
158Irregular epiphyses (HP:0010582)1.55149634
159Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.54911245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.89841728
2NME24.71794309
3BUB14.19582037
4WEE13.98848104
5EIF2AK12.87041786
6TLK12.71269160
7TAF12.55321980
8CDC72.48035808
9NEK22.38464924
10EPHB22.23133315
11SRPK12.22494505
12PIM22.09468218
13VRK12.04370669
14PNCK2.01639295
15RPS6KB21.96583793
16LRRK21.94734874
17BRSK21.93641583
18PLK41.90026640
19TESK21.85242464
20STK161.83653128
21TSSK61.83324664
22EEF2K1.79995806
23RPS6KA41.79350823
24MAPK151.73122608
25AURKB1.64230576
26PLK11.62237282
27FGFR21.58177689
28DYRK21.57539547
29EPHA21.54577786
30PASK1.50347399
31TTK1.48418575
32NEK11.48018858
33EIF2AK31.47083200
34CDK71.46687820
35NUAK11.42255766
36DYRK31.41580507
37TNIK1.35462871
38MAP3K81.34711855
39PAK41.30398049
40ACVR1B1.27656178
41MKNK11.25839689
42ILK1.24233186
43MAP3K101.23123456
44TESK11.21426248
45SCYL21.20782238
46BRSK11.18281022
47ATR1.17171041
48AURKA1.12295221
49BMPR1B1.10714854
50ZAK1.09806502
51KDR1.08262161
52PLK31.07793478
53STK101.07577090
54MAP4K11.07247038
55TGFBR11.06654322
56PIM11.06583168
57NME11.05248050
58WNK31.05088527
59STK240.98803356
60CDK40.98319368
61CDK190.97633726
62STK40.97553617
63CHEK20.96261282
64MAP3K110.93316050
65PKN20.93055155
66TRIB30.87771747
67INSRR0.83983251
68PAK10.83505403
69MKNK20.82139055
70MAP3K120.81267737
71CHEK10.79521738
72FLT30.78573713
73PRKCI0.75175309
74CSNK2A20.71685720
75IRAK30.69649149
76PBK0.69625624
77MUSK0.69502616
78BRAF0.69327461
79EIF2AK20.69130540
80CSNK2A10.68471342
81NLK0.67353669
82ABL20.63252390
83ERN10.62357843
84FGFR10.62280488
85RPS6KA50.62170071
86MST40.61195669
87CDK30.60594332
88MAP2K20.60276557
89MAP2K30.59348251
90GRK10.58879629
91CDK20.57681000
92ADRBK20.57287876
93CDK80.57137286
94DAPK30.57119113
95IKBKB0.55864963
96PRKCG0.54654326
97MAPKAPK30.53989701
98TYK20.52849529
99BCKDK0.52287977
100LATS20.52068712
101MAP3K30.51585472
102BTK0.51430943
103ALK0.51113213
104ATM0.50980698
105CDK60.49697685
106WNK40.46169393
107UHMK10.45390520
108CSNK1E0.45355491
109CCNB10.45240315
110TEC0.44692747
111STK30.44531550
112CASK0.43883389
113PAK20.42136559
114BLK0.40699917
115ADRBK10.38521457
116ARAF0.38350746
117EPHA40.35908289
118TBK10.35500132
119AKT20.35308064
120ZAP700.35221592
121MAPKAPK50.33668271
122STK38L0.32975519
123CDK10.32306969
124LIMK10.29544215
125RPS6KC10.29275022
126RPS6KL10.29275022
127CHUK0.29163296
128TYRO30.29132267
129MAPKAPK20.29131293
130STK390.28317118
131RPS6KA60.28078767
132MARK30.27696605
133MELK0.26280027
134DYRK1B0.25517460
135PDK20.20365749
136PRKACA0.18130589
137PRKCD0.17704894
138PTK60.17308948
139PRKACB0.17250209
140CAMK10.17233957
141PIK3CA0.16881919
142CSNK1A10.16611010
143OXSR10.15569852
144PRKDC0.14523683

Predicted pathways (KEGG)

RankGene SetZ-score
1* Ribosome_Homo sapiens_hsa030106.13604999
2DNA replication_Homo sapiens_hsa030304.18555545
3RNA polymerase_Homo sapiens_hsa030203.55445308
4Proteasome_Homo sapiens_hsa030503.49350234
5Mismatch repair_Homo sapiens_hsa034303.41328426
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09731391
7Spliceosome_Homo sapiens_hsa030403.09357318
8Pyrimidine metabolism_Homo sapiens_hsa002402.65329704
9Homologous recombination_Homo sapiens_hsa034402.61652028
10RNA transport_Homo sapiens_hsa030132.61028810
11Base excision repair_Homo sapiens_hsa034102.49190531
12Nucleotide excision repair_Homo sapiens_hsa034202.44474948
13One carbon pool by folate_Homo sapiens_hsa006702.17252627
14Cell cycle_Homo sapiens_hsa041102.08209037
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89208359
16Fanconi anemia pathway_Homo sapiens_hsa034601.63778563
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.55127728
18RNA degradation_Homo sapiens_hsa030181.53505836
19p53 signaling pathway_Homo sapiens_hsa041151.52705651
20Protein export_Homo sapiens_hsa030601.42752803
21Basal transcription factors_Homo sapiens_hsa030221.41186361
22Parkinsons disease_Homo sapiens_hsa050121.37399471
23Non-homologous end-joining_Homo sapiens_hsa034501.34529857
24Systemic lupus erythematosus_Homo sapiens_hsa053221.31597534
25Oxidative phosphorylation_Homo sapiens_hsa001901.29547553
26Purine metabolism_Homo sapiens_hsa002301.28700808
27Huntingtons disease_Homo sapiens_hsa050161.26541007
28Sulfur relay system_Homo sapiens_hsa041221.18499005
29Pentose phosphate pathway_Homo sapiens_hsa000301.12346782
30Epstein-Barr virus infection_Homo sapiens_hsa051691.11102297
31mRNA surveillance pathway_Homo sapiens_hsa030151.09836035
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.09700304
33Folate biosynthesis_Homo sapiens_hsa007900.98523338
34Antigen processing and presentation_Homo sapiens_hsa046120.97837916
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96527586
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95057153
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92218593
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.90797988
39Viral carcinogenesis_Homo sapiens_hsa052030.85088779
40Herpes simplex infection_Homo sapiens_hsa051680.84089339
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.77324087
42Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76341715
43Pyruvate metabolism_Homo sapiens_hsa006200.71553788
44Legionellosis_Homo sapiens_hsa051340.71076304
45Glutathione metabolism_Homo sapiens_hsa004800.69626995
46HTLV-I infection_Homo sapiens_hsa051660.67674182
47Alzheimers disease_Homo sapiens_hsa050100.67604786
48Vitamin digestion and absorption_Homo sapiens_hsa049770.67153522
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65811714
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.65509613
51Thyroid cancer_Homo sapiens_hsa052160.60927016
52Small cell lung cancer_Homo sapiens_hsa052220.59260587
53Selenocompound metabolism_Homo sapiens_hsa004500.59163788
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58757652
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58613871
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58243447
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58058102
58Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57255604
59Apoptosis_Homo sapiens_hsa042100.56969845
60N-Glycan biosynthesis_Homo sapiens_hsa005100.56571326
61Nitrogen metabolism_Homo sapiens_hsa009100.55768727
62Biosynthesis of amino acids_Homo sapiens_hsa012300.55039783
63Bladder cancer_Homo sapiens_hsa052190.50751604
64Propanoate metabolism_Homo sapiens_hsa006400.48090734
65Chemical carcinogenesis_Homo sapiens_hsa052040.47855485
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45724628
67Fructose and mannose metabolism_Homo sapiens_hsa000510.45342583
68Primary immunodeficiency_Homo sapiens_hsa053400.45137364
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44796098
70Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44259462
71Vitamin B6 metabolism_Homo sapiens_hsa007500.43800205
72Oocyte meiosis_Homo sapiens_hsa041140.43690058
73Phototransduction_Homo sapiens_hsa047440.43626964
74Cyanoamino acid metabolism_Homo sapiens_hsa004600.43581686
75Linoleic acid metabolism_Homo sapiens_hsa005910.43278668
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.41513561
77Basal cell carcinoma_Homo sapiens_hsa052170.39923356
78Wnt signaling pathway_Homo sapiens_hsa043100.39062490
79Butanoate metabolism_Homo sapiens_hsa006500.38862148
80Alcoholism_Homo sapiens_hsa050340.38768897
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.38721905
82Measles_Homo sapiens_hsa051620.38052054
83MicroRNAs in cancer_Homo sapiens_hsa052060.37871328
84NF-kappa B signaling pathway_Homo sapiens_hsa040640.37026445
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35912229
86Galactose metabolism_Homo sapiens_hsa000520.35911224
87Hematopoietic cell lineage_Homo sapiens_hsa046400.35384637
88Carbon metabolism_Homo sapiens_hsa012000.35112192
89Hepatitis B_Homo sapiens_hsa051610.33333014
90Shigellosis_Homo sapiens_hsa051310.33287675
91TGF-beta signaling pathway_Homo sapiens_hsa043500.32516720
92HIF-1 signaling pathway_Homo sapiens_hsa040660.30636760
93Peroxisome_Homo sapiens_hsa041460.30628237
94Acute myeloid leukemia_Homo sapiens_hsa052210.30215209
95Metabolic pathways_Homo sapiens_hsa011000.29760739
96Chronic myeloid leukemia_Homo sapiens_hsa052200.28956845
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28299520
98Arachidonic acid metabolism_Homo sapiens_hsa005900.28131286
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27836616
100Tyrosine metabolism_Homo sapiens_hsa003500.27628451
101Caffeine metabolism_Homo sapiens_hsa002320.26951464
102Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.26691812
103Tryptophan metabolism_Homo sapiens_hsa003800.26542477
104Fatty acid elongation_Homo sapiens_hsa000620.26326960
105Influenza A_Homo sapiens_hsa051640.26258425
106Hippo signaling pathway_Homo sapiens_hsa043900.26254071
107Collecting duct acid secretion_Homo sapiens_hsa049660.25741676
108Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25449381
109Asthma_Homo sapiens_hsa053100.24999269
110Allograft rejection_Homo sapiens_hsa053300.24627690
111Retinol metabolism_Homo sapiens_hsa008300.24609262
112Leishmaniasis_Homo sapiens_hsa051400.23715177
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22805503
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.21612525
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21335822
116Pathways in cancer_Homo sapiens_hsa052000.21116815
117Mineral absorption_Homo sapiens_hsa049780.20044070
118Notch signaling pathway_Homo sapiens_hsa043300.20002975
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.19625087
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.17810133
121Fat digestion and absorption_Homo sapiens_hsa049750.16632652
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.15927957
123Renin-angiotensin system_Homo sapiens_hsa046140.15752507
124Other glycan degradation_Homo sapiens_hsa005110.15339133
125Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.14893709
126Colorectal cancer_Homo sapiens_hsa052100.14583301
127Graft-versus-host disease_Homo sapiens_hsa053320.14211163
128Hedgehog signaling pathway_Homo sapiens_hsa043400.13606134
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.13489344
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12623085
131Viral myocarditis_Homo sapiens_hsa054160.12112101
132Cardiac muscle contraction_Homo sapiens_hsa042600.12051281
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11926847
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.11760715
135Melanogenesis_Homo sapiens_hsa049160.09538379
136Arginine and proline metabolism_Homo sapiens_hsa003300.08019247
137beta-Alanine metabolism_Homo sapiens_hsa004100.06772190
138Steroid biosynthesis_Homo sapiens_hsa001000.05661983
139Taste transduction_Homo sapiens_hsa047420.04322665
140Sulfur metabolism_Homo sapiens_hsa009200.03709670

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