RPL41P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003609.72864072
2negative regulation of cardiac muscle hypertrophy (GO:0010614)9.37306071
3negative regulation of glycogen biosynthetic process (GO:0045719)9.12937743
4interleukin-6-mediated signaling pathway (GO:0070102)8.98346032
5galactose catabolic process (GO:0019388)8.47740883
6negative regulation of muscle hypertrophy (GO:0014741)8.47686519
7establishment of skin barrier (GO:0061436)8.43181652
8regulation of interleukin-12 biosynthetic process (GO:0045075)8.41142287
9tolerance induction (GO:0002507)8.38172203
10regulation of oxidative stress-induced neuron death (GO:1903203)8.29520942
11membrane tubulation (GO:0097320)8.15237670
12regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00438.05357811
13protein localization to endosome (GO:0036010)7.95241335
14N-terminal protein amino acid acetylation (GO:0006474)7.85478974
15regulation of energy homeostasis (GO:2000505)7.78385750
16negative regulation of glycogen metabolic process (GO:0070874)7.33627746
17regulation of water loss via skin (GO:0033561)7.07316639
18cellular response to interleukin-6 (GO:0071354)6.68468894
19regulation of cellular respiration (GO:0043457)6.40710560
20ribosomal small subunit biogenesis (GO:0042274)5.68702419
21response to interleukin-6 (GO:0070741)5.48546686
22forebrain morphogenesis (GO:0048853)5.21483202
23cysteine metabolic process (GO:0006534)5.14531852
24viral transcription (GO:0019083)5.13676941
25galactose metabolic process (GO:0006012)4.88881157
26translational termination (GO:0006415)4.86420774
27protein heterotetramerization (GO:0051290)4.81975908
28desmosome organization (GO:0002934)4.47250267
29multicellular organismal water homeostasis (GO:0050891)4.45915748
30ubiquinone biosynthetic process (GO:0006744)4.23541675
31response to nitrosative stress (GO:0051409)4.19105765
32sequestering of actin monomers (GO:0042989)4.13908586
33viral life cycle (GO:0019058)4.10357059
34ribonucleoprotein complex biogenesis (GO:0022613)4.04965161
35regulation of hypersensitivity (GO:0002883)4.03037280
36megakaryocyte development (GO:0035855)4.00157607
37spermatid nucleus differentiation (GO:0007289)3.96850531
38regulation of the force of heart contraction (GO:0002026)3.96663191
39epithelial cell differentiation involved in prostate gland development (GO:0060742)3.89842444
40SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.87328167
41keratinocyte proliferation (GO:0043616)3.85427219
42water homeostasis (GO:0030104)3.84315661
43tyrosine metabolic process (GO:0006570)3.84186531
44regulation of natural killer cell differentiation (GO:0032823)3.82842686
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.81432152
46L-phenylalanine catabolic process (GO:0006559)3.81432152
47ribosomal large subunit biogenesis (GO:0042273)3.79921071
48cotranslational protein targeting to membrane (GO:0006613)3.79635571
49negative regulation of potassium ion transport (GO:0043267)3.79538326
50ubiquinone metabolic process (GO:0006743)3.77826028
51protein targeting to ER (GO:0045047)3.74945031
52regulation of cardiac muscle hypertrophy (GO:0010611)3.74185311
53translational elongation (GO:0006414)3.69446417
54regulation of chromatin binding (GO:0035561)3.69143380
55ribosome biogenesis (GO:0042254)3.66102831
56lymph node development (GO:0048535)3.64748315
57regulation of muscle hypertrophy (GO:0014743)3.61849209
58quinone biosynthetic process (GO:1901663)3.58981210
59cellular protein complex disassembly (GO:0043624)3.58564328
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.57234679
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46439569
62endosome to melanosome transport (GO:0035646)3.45796667
63endosome to pigment granule transport (GO:0043485)3.45796667
64protein localization to endoplasmic reticulum (GO:0070972)3.43355441
65valine metabolic process (GO:0006573)3.42455377
66otic vesicle formation (GO:0030916)3.32762672
67superoxide anion generation (GO:0042554)3.27847380
68negative regulation of erythrocyte differentiation (GO:0045647)3.27836636
69positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)3.25260606
70regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)3.25260606
71erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.23906534
72L-phenylalanine metabolic process (GO:0006558)3.23906534
73negative regulation of JAK-STAT cascade (GO:0046426)3.22091139
74N-terminal protein amino acid modification (GO:0031365)3.18628937
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.17652094
76interkinetic nuclear migration (GO:0022027)3.15441894
77regulation of respiratory gaseous exchange (GO:0043576)3.12080144
78vesicle fusion (GO:0006906)3.10713330
79negative thymic T cell selection (GO:0045060)3.10350271
80positive regulation of gamma-delta T cell activation (GO:0046645)3.07363069
81positive regulation of T cell apoptotic process (GO:0070234)3.02970082
82protein complex disassembly (GO:0043241)3.02124567
83keratinocyte differentiation (GO:0030216)2.99645308
84regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.95975902
85positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.95975902
86regulation of proton transport (GO:0010155)2.95817148
87activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.93524551
88regulation of gamma-delta T cell differentiation (GO:0045586)2.92335571
89CDP-diacylglycerol biosynthetic process (GO:0016024)2.91277859
90regulation of mammary gland epithelial cell proliferation (GO:0033599)2.90144028
91antimicrobial humoral response (GO:0019730)2.88163029
92endosome to lysosome transport (GO:0008333)2.87735611
93positive regulation of positive chemotaxis (GO:0050927)2.85299643
94negative T cell selection (GO:0043383)2.84473876
95regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.84132645
96positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.83463839
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.83061861
98dendrite development (GO:0016358)2.82075538
99innate immune response in mucosa (GO:0002227)2.78183411
100keratinization (GO:0031424)11.3132624

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.49880876
2SRY_22984422_ChIP-ChIP_TESTIS_Rat3.41308889
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.96756858
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72253540
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72253540
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72253540
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.60614885
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.56215081
9DROSHA_22980978_ChIP-Seq_HELA_Human2.50401030
10SCL_19346495_ChIP-Seq_HPC-7_Human2.36728460
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.31248655
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.30484537
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.20747644
14PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.15799624
15GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse2.11901233
16VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.01766272
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99931815
18EZH2_27304074_Chip-Seq_ESCs_Mouse1.98931298
19TP63_19390658_ChIP-ChIP_HaCaT_Human1.96146380
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.92074450
21PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.89752362
22EGR1_19374776_ChIP-ChIP_THP-1_Human1.87816359
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87200240
24STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79367768
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.73931410
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71856847
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.70831179
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.58954260
29JARID2_20075857_ChIP-Seq_MESCs_Mouse1.57902174
30SMAD_19615063_ChIP-ChIP_OVARY_Human1.53487269
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.50703744
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.50703744
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50359183
34EZH2_27294783_Chip-Seq_ESCs_Mouse1.49892379
35EGR1_19032775_ChIP-ChIP_M12_Human1.48937371
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.47909897
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46863894
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.45333375
39BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44705789
40HTT_18923047_ChIP-ChIP_STHdh_Human1.44307315
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.44297020
42SMAD3_21741376_ChIP-Seq_HESCs_Human1.43739105
43RXRA_24833708_ChIP-Seq_LIVER_Mouse1.42751497
44CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.42095204
45P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37666914
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.36017328
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35734494
48TP53_20018659_ChIP-ChIP_R1E_Mouse1.32692650
49PPAR_26484153_Chip-Seq_NCI-H1993_Human1.30352677
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.30296485
51RUNX_20019798_ChIP-Seq_JUKART_Human1.26790153
52DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24555845
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22592460
54ZNF274_21170338_ChIP-Seq_K562_Hela1.17784520
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16804900
56GATA1_22025678_ChIP-Seq_K562_Human1.15438451
57SPI1_23127762_ChIP-Seq_K562_Human1.14654070
58FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14086644
59P300_27268052_Chip-Seq_Bcells_Human1.12590288
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.11709415
61CBP_20019798_ChIP-Seq_JUKART_Human1.11709415
62TP53_22127205_ChIP-Seq_IMR90_Human1.11698209
63RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09912238
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09342164
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.08096428
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.07947603
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.07407662
68RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06044800
69CDX2_20551321_ChIP-Seq_CACO-2_Human1.05937198
70RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05200083
71AHR_22903824_ChIP-Seq_MCF-7_Human1.03587384
72SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03540377
73RING1B_27294783_Chip-Seq_ESCs_Mouse1.03219279
74SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.02853783
75BCAT_22108803_ChIP-Seq_LS180_Human1.02412778
76STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.02261605
77SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.01487620
78ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00772246
79PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98334325
80PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97545846
81TP63_22573176_ChIP-Seq_HFKS_Human0.94243844
82GATA3_27048872_Chip-Seq_THYMUS_Human0.94202303
83GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.93965977
84SA1_27219007_Chip-Seq_Bcells_Human0.93860692
85NANOG_20526341_ChIP-Seq_ESCs_Human0.90696388
86GBX2_23144817_ChIP-Seq_PC3_Human0.89217632
87ERG_20517297_ChIP-Seq_VCAP_Human0.89079142
88SMAD4_21741376_ChIP-Seq_HESCs_Human0.88955622
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87920158
90GF1_26923725_Chip-Seq_HPCs_Mouse0.87863960
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.87451224
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.87255740
93FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86691816
94EZH2_22144423_ChIP-Seq_EOC_Human0.85909153
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85541517
96KAP1_27257070_Chip-Seq_ESCs_Mouse0.84979212
97AR_25329375_ChIP-Seq_VCAP_Human0.84176706
98STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.83828424
99RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.83645935
100TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83437176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage8.62889385
2MP0002796_impaired_skin_barrier5.81631558
3MP0002653_abnormal_ependyma_morphology5.64648310
4MP0005623_abnormal_meninges_morphology5.44876917
5MP0002837_dystrophic_cardiac_calcinosis5.27554514
6MP0005275_abnormal_skin_tensile4.60310483
7MP0004084_abnormal_cardiac_muscle4.30971073
8MP0003279_aneurysm4.15378710
9MP0001915_intracranial_hemorrhage3.19877489
10MP0005501_abnormal_skin_physiology2.79826295
11MP0003941_abnormal_skin_development2.53578421
12MP0009379_abnormal_foot_pigmentation2.34111961
13MP0004036_abnormal_muscle_relaxation2.30184679
14MP0004145_abnormal_muscle_electrophysio2.25983115
15MP0004130_abnormal_muscle_cell2.01759690
16MP0001346_abnormal_lacrimal_gland1.82538853
17MP0004215_abnormal_myocardial_fiber1.78178104
18MP0000579_abnormal_nail_morphology1.70221144
19MP0003011_delayed_dark_adaptation1.56372878
20MP0005377_hearing/vestibular/ear_phenot1.52931787
21MP0003878_abnormal_ear_physiology1.52931787
22MP0004185_abnormal_adipocyte_glucose1.51688923
23MP0000767_abnormal_smooth_muscle1.47562159
24MP0004484_altered_response_of1.43874326
25MP0002163_abnormal_gland_morphology1.32551374
26MP0001986_abnormal_taste_sensitivity1.32480666
27MP0003191_abnormal_cellular_cholesterol1.28071965
28MP0004885_abnormal_endolymph1.25605386
29MP0006292_abnormal_olfactory_placode1.23063081
30MP0000678_abnormal_parathyroid_gland1.19324208
31MP0009333_abnormal_splenocyte_physiolog1.18411426
32MP0005220_abnormal_exocrine_pancreas1.16607947
33MP0001216_abnormal_epidermal_layer1.15648744
34MP0010155_abnormal_intestine_physiology1.15326088
35MP0003186_abnormal_redox_activity1.13085072
36MP0003705_abnormal_hypodermis_morpholog1.12553278
37MP0003300_gastrointestinal_ulcer1.09777246
38MP0010771_integument_phenotype1.08727446
39MP0004947_skin_inflammation1.07856405
40MP0001764_abnormal_homeostasis1.05733904
41MP0009250_abnormal_appendicular_skeleto1.03162997
42MP0009765_abnormal_xenobiotic_induced1.00934230
43MP0010352_gastrointestinal_tract_polyps1.00928046
44MP0002697_abnormal_eye_size1.00583347
45MP0004782_abnormal_surfactant_physiolog1.00425641
46MP0003195_calcinosis0.98786355
47MP0001340_abnormal_eyelid_morphology0.93201134
48MP0003633_abnormal_nervous_system0.91091293
49MP0000465_gastrointestinal_hemorrhage0.89670083
50MP0001286_abnormal_eye_development0.88466556
51MP0005165_increased_susceptibility_to0.86940692
52MP0001348_abnormal_lacrimal_gland0.84762019
53MP0005503_abnormal_tendon_morphology0.82832314
54MP0009785_altered_susceptibility_to0.80715340
55MP0002693_abnormal_pancreas_physiology0.78971931
56MP0008775_abnormal_heart_ventricle0.77980098
57MP0001191_abnormal_skin_condition0.77612310
58MP0002060_abnormal_skin_morphology0.76884693
59MP0005448_abnormal_energy_balance0.72844421
60MP0001661_extended_life_span0.69901429
61MP0003453_abnormal_keratinocyte_physiol0.69867446
62MP0003631_nervous_system_phenotype0.69018805
63MP0000377_abnormal_hair_follicle0.68326166
64MP0003303_peritoneal_inflammation0.68118879
65MP0002160_abnormal_reproductive_system0.68083540
66MP0001800_abnormal_humoral_immune0.67021853
67MP0001784_abnormal_fluid_regulation0.64807177
68MP0005023_abnormal_wound_healing0.63016903
69MP0002972_abnormal_cardiac_muscle0.62315536
70MP0005379_endocrine/exocrine_gland_phen0.60152643
71MP0005197_abnormal_uvea_morphology0.59813421
72MP0001188_hyperpigmentation0.55418803
73MP0000367_abnormal_coat/_hair0.54588244
74MP0005647_abnormal_sex_gland0.54074538
75MP0000762_abnormal_tongue_morphology0.51129443
76MP0003646_muscle_fatigue0.49713366
77MP0004197_abnormal_fetal_growth/weight/0.47349884
78MP0002095_abnormal_skin_pigmentation0.45587807
79MP0005334_abnormal_fat_pad0.44142387
80MP0009931_abnormal_skin_appearance0.43938416
81MP0002723_abnormal_immune_serum0.41553965
82MP0005376_homeostasis/metabolism_phenot0.41537292
83MP0005385_cardiovascular_system_phenoty0.40908829
84MP0001544_abnormal_cardiovascular_syste0.40908829
85MP0000685_abnormal_immune_system0.40664175
86MP0005193_abnormal_anterior_eye0.38971665
87MP0002234_abnormal_pharynx_morphology0.37441291
88MP0005375_adipose_tissue_phenotype0.36411481
89MP0000477_abnormal_intestine_morphology0.35465280
90MP0002106_abnormal_muscle_physiology0.35342887
91MP0005620_abnormal_muscle_contractility0.34030073
92MP0000428_abnormal_craniofacial_morphol0.34028918
93MP0000534_abnormal_ureter_morphology0.33743906
94MP0000647_abnormal_sebaceous_gland0.32852178
95MP0002896_abnormal_bone_mineralization0.32656327
96MP0003866_abnormal_defecation0.32615608
97MP0000627_abnormal_mammary_gland0.32576739
98MP0000566_synostosis0.32428889
99MP0010234_abnormal_vibrissa_follicle0.31578443
100MP0005666_abnormal_adipose_tissue0.31118746

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of nail color (HP:0100643)7.25228099
2Progressive inability to walk (HP:0002505)5.62728402
3Increased IgE level (HP:0003212)5.62054801
4Abnormality of the axillary hair (HP:0100134)5.49826693
5Abnormality of secondary sexual hair (HP:0009888)5.49826693
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.45972613
7Absent/shortened dynein arms (HP:0200106)5.45972613
8Onycholysis (HP:0001806)5.29526295
9Premature ovarian failure (HP:0008209)5.12125784
10Mutism (HP:0002300)5.11273417
11Hypergonadotropic hypogonadism (HP:0000815)4.91477204
12Chronic otitis media (HP:0000389)4.76874916
13Erythroderma (HP:0001019)4.54186507
14Hypotrichosis (HP:0001006)4.51495621
15Loss of speech (HP:0002371)4.50154515
16Congenital ichthyosiform erythroderma (HP:0007431)4.49552717
17Alopecia of scalp (HP:0002293)4.47351111
18Abnormal number of erythroid precursors (HP:0012131)4.34199279
19Palmoplantar hyperkeratosis (HP:0000972)4.24184282
20Corneal erosion (HP:0200020)4.12866223
21Palmar hyperkeratosis (HP:0010765)3.97873679
22Abnormality of cells of the erythroid lineage (HP:0012130)3.91264601
23Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.87776793
24Disinhibition (HP:0000734)3.74768362
25Aortic regurgitation (HP:0001659)3.65270332
26Plantar hyperkeratosis (HP:0007556)3.44424961
27Dyskinesia (HP:0100660)3.28867446
28Chronic sinusitis (HP:0011109)3.24084403
29Erythema (HP:0010783)3.08842572
30Abnormal ciliary motility (HP:0012262)3.04206822
31Gangrene (HP:0100758)2.99530735
32Absent eyelashes (HP:0000561)2.99438088
33Sepsis (HP:0100806)2.97490942
34Abnormal respiratory epithelium morphology (HP:0012253)2.96103044
35Abnormal respiratory motile cilium morphology (HP:0005938)2.96103044
36Absent hair (HP:0002298)2.84600835
37Hypohidrosis (HP:0000966)2.78031679
38Parakeratosis (HP:0001036)2.73186950
39Elfin facies (HP:0004428)2.52421255
40Sparse eyelashes (HP:0000653)2.51299146
41Inability to walk (HP:0002540)2.49013771
42Oral leukoplakia (HP:0002745)2.47610470
43Palmoplantar keratoderma (HP:0000982)2.42416440
44Overriding aorta (HP:0002623)2.37027207
45Agammaglobulinemia (HP:0004432)2.33090606
46Mitral regurgitation (HP:0001653)2.31985263
47Furrowed tongue (HP:0000221)2.22516796
48Renovascular hypertension (HP:0100817)2.19928695
49Ectropion (HP:0000656)2.18359297
50Genetic anticipation (HP:0003743)2.17257171
51Rhinitis (HP:0012384)2.15023231
52Stomatitis (HP:0010280)2.14791610
53Pustule (HP:0200039)2.14488466
54Delayed epiphyseal ossification (HP:0002663)2.11972684
55Hyperacusis (HP:0010780)2.10077936
56Abnormal respiratory motile cilium physiology (HP:0012261)2.09793940
57Flat cornea (HP:0007720)2.08501812
58Submucous cleft hard palate (HP:0000176)2.08430194
59Thick nail (HP:0001805)2.06710218
60Elevated erythrocyte sedimentation rate (HP:0003565)2.06040171
61Personality changes (HP:0000751)2.00530109
62Right ventricular cardiomyopathy (HP:0011663)2.00274815
63Chronic hepatic failure (HP:0100626)10.4608368
64Renal duplication (HP:0000075)1.99713985
65Enlarged epiphyses (HP:0010580)1.99657866
66Bladder diverticulum (HP:0000015)1.99264628
67Apathy (HP:0000741)1.96933759
68Thin bony cortex (HP:0002753)1.96888848
69Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.94737457
70Chronic diarrhea (HP:0002028)1.92606224
71Abnormality of the nasal septum (HP:0000419)1.92267474
72Septate vagina (HP:0001153)1.91073909
73Pruritus (HP:0000989)1.88965887
74Depressed nasal tip (HP:0000437)1.87376069
75Inappropriate behavior (HP:0000719)1.87346002
76Hypergammaglobulinemia (HP:0010702)1.86711848
77Centrally nucleated skeletal muscle fibers (HP:0003687)1.86116126
78Malignant hyperthermia (HP:0002047)1.82656109
79Lip pit (HP:0100267)1.78226314
80Dysmetric saccades (HP:0000641)1.77155226
81Hallux valgus (HP:0001822)1.73732857
82Nail dystrophy (HP:0008404)1.72609055
83Systemic lupus erythematosus (HP:0002725)1.72431478
84Abnormal number of incisors (HP:0011064)1.70685175
85Split foot (HP:0001839)1.68057627
86Widely patent fontanelles and sutures (HP:0004492)1.67933132
87Eczematoid dermatitis (HP:0000976)1.67517190
88Abnormality of the diencephalon (HP:0010662)1.67347134
89Diminished motivation (HP:0000745)1.66532368
90Hepatocellular necrosis (HP:0001404)1.65042270
91Abnormality of placental membranes (HP:0011409)1.63669217
92Amniotic constriction ring (HP:0009775)1.63669217
93Sparse scalp hair (HP:0002209)1.62470318
94Hamartoma of the eye (HP:0010568)1.62397888
95Deviation of the hallux (HP:0010051)1.62042372
96Bulbous nose (HP:0000414)1.61395733
97Restlessness (HP:0000711)1.59003872
98Anhidrosis (HP:0000970)1.58930975
99Insomnia (HP:0100785)1.54841538
100Oligodontia (HP:0000677)1.53186571

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K136.75982516
2CAMKK15.78538106
3TXK3.45975379
4RIPK42.98632288
5MAP3K142.48396915
6LRRK22.27761670
7SIK22.16962698
8BRSK22.07795859
9PASK11.5285280
10CAMKK21.99672418
11MAP4K11.98852484
12TGFBR11.56182076
13JAK31.42895554
14MAP3K71.25439243
15BTK1.12629387
16TYRO31.01304908
17IKBKB0.95514522
18MAPKAPK30.94007789
19BRSK10.82336430
20SYK0.79436465
21STK380.78895427
22TEC0.77477767
23CHUK0.74224762
24ACVR1B0.73989380
25NEK20.69313893
26PAK60.68090382
27ITK0.67963558
28PRKCQ0.65371074
29PTK60.63231920
30SGK2230.61350747
31SGK4940.61350747
32LCK0.59490119
33YES10.58460429
34ZAP700.58232664
35FRK0.57815262
36STK110.57564040
37BMPR1B0.57480622
38PRKAA20.55975334
39MARK30.51687262
40ADRBK20.50812096
41STK40.48927471
42CLK10.44516867
43PIK3CG0.44424724
44FGR0.41692272
45SGK10.37696046
46PAK20.35719179
47INSRR0.34360051
48PRKCZ0.33937763
49JAK20.32388879
50EEF2K0.29036624
51CSNK1A1L0.28910628
52PRKCD0.28556783
53KIT0.28538533
54LYN0.26885784
55DYRK20.25537387
56CSNK1G30.25368325
57ADRBK10.25067490
58OBSCN0.24214440
59MAPK130.22875407
60MAPK150.21777138
61MKNK20.21188908
62MAPKAPK20.19453797
63CSNK1G10.18914888
64MUSK0.17064148
65HCK0.16604624
66RPS6KB20.16323576
67RPS6KA50.15040521
68MAPK120.14596856
69KDR0.14504804
70DMPK0.12423170
71ERBB20.11819795
72FGFR10.11477037
73IGF1R0.11240465
74PDK10.11172681
75SGK20.09827121
76TIE10.09787464
77CSNK1G20.09769147
78GRK70.09087408
79GRK10.08099781
80PRKCA0.07332535
81RPS6KA30.07309767
82FYN0.06953293
83MAP4K20.06839400
84PAK10.06796218
85FGFR20.06445254
86MAPK140.06251459
87AKT30.04693645
88SRC0.03913300
89MAP2K60.03888365
90MAPK110.03257105
91GRK60.02794910
92ERBB40.02365589
93WNK10.01804032
94JAK10.01801406
95PRKACG0.01670843
96PDGFRB0.01238918
97DDR20.00729254
98CAMK2B-0.0069489
99FGFR3-0.0047463
100WNK3-0.0020191

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.75756205
2Ribosome_Homo sapiens_hsa030104.04218821
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.90251891
4Galactose metabolism_Homo sapiens_hsa000522.84243736
5SNARE interactions in vesicular transport_Homo sapiens_hsa041302.64849163
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.43183212
7Staphylococcus aureus infection_Homo sapiens_hsa051502.37084396
8Cocaine addiction_Homo sapiens_hsa050302.16969707
9Amphetamine addiction_Homo sapiens_hsa050311.93557320
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64747569
11Long-term potentiation_Homo sapiens_hsa047201.64681162
12Prolactin signaling pathway_Homo sapiens_hsa049171.61110764
13Glycerolipid metabolism_Homo sapiens_hsa005611.60981065
14Phototransduction_Homo sapiens_hsa047441.59065618
15Tyrosine metabolism_Homo sapiens_hsa003501.51887884
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.50127830
17Rheumatoid arthritis_Homo sapiens_hsa053231.49396842
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49059127
19GnRH signaling pathway_Homo sapiens_hsa049121.44776132
20Acute myeloid leukemia_Homo sapiens_hsa052211.43815534
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.28498539
22Adipocytokine signaling pathway_Homo sapiens_hsa049201.28159016
23Asthma_Homo sapiens_hsa053101.27073969
24Type I diabetes mellitus_Homo sapiens_hsa049401.26342237
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19929641
26ABC transporters_Homo sapiens_hsa020101.19641054
27Autoimmune thyroid disease_Homo sapiens_hsa053201.19333121
28Type II diabetes mellitus_Homo sapiens_hsa049301.13473690
29Glucagon signaling pathway_Homo sapiens_hsa049221.12950853
30Graft-versus-host disease_Homo sapiens_hsa053321.11036543
31Allograft rejection_Homo sapiens_hsa053301.09670261
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.02689031
33TGF-beta signaling pathway_Homo sapiens_hsa043501.02501791
34Prostate cancer_Homo sapiens_hsa052150.99432385
35TNF signaling pathway_Homo sapiens_hsa046680.98025015
36Estrogen signaling pathway_Homo sapiens_hsa049150.97901998
37Thyroid hormone synthesis_Homo sapiens_hsa049180.96677066
38T cell receptor signaling pathway_Homo sapiens_hsa046600.94970883
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94321580
40p53 signaling pathway_Homo sapiens_hsa041150.92065873
41Steroid biosynthesis_Homo sapiens_hsa001000.91511897
42Insulin secretion_Homo sapiens_hsa049110.89651686
43Olfactory transduction_Homo sapiens_hsa047400.86693799
44Linoleic acid metabolism_Homo sapiens_hsa005910.84984542
45Chemokine signaling pathway_Homo sapiens_hsa040620.83036239
46Regulation of autophagy_Homo sapiens_hsa041400.78177118
47Pertussis_Homo sapiens_hsa051330.78162316
48PPAR signaling pathway_Homo sapiens_hsa033200.77084142
49Intestinal immune network for IgA production_Homo sapiens_hsa046720.76324536
50Shigellosis_Homo sapiens_hsa051310.75787277
51cAMP signaling pathway_Homo sapiens_hsa040240.75409685
52Nitrogen metabolism_Homo sapiens_hsa009100.75377052
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70861505
54Histidine metabolism_Homo sapiens_hsa003400.70859819
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69556767
56Primary immunodeficiency_Homo sapiens_hsa053400.68321177
57Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67892578
58Hepatitis B_Homo sapiens_hsa051610.63362265
59Measles_Homo sapiens_hsa051620.63030129
60Serotonergic synapse_Homo sapiens_hsa047260.61763509
61Insulin resistance_Homo sapiens_hsa049310.61603999
62Apoptosis_Homo sapiens_hsa042100.58878534
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58687455
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58546665
65B cell receptor signaling pathway_Homo sapiens_hsa046620.57246222
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57184742
67Complement and coagulation cascades_Homo sapiens_hsa046100.55207595
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.54919524
69Renin secretion_Homo sapiens_hsa049240.52889776
70Gastric acid secretion_Homo sapiens_hsa049710.52559680
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52123923
72Retinol metabolism_Homo sapiens_hsa008300.50606336
73African trypanosomiasis_Homo sapiens_hsa051430.49970386
74HTLV-I infection_Homo sapiens_hsa051660.49961242
75Influenza A_Homo sapiens_hsa051640.47201473
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47192794
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47097908
78Hematopoietic cell lineage_Homo sapiens_hsa046400.46439226
79mTOR signaling pathway_Homo sapiens_hsa041500.46415236
80Arachidonic acid metabolism_Homo sapiens_hsa005900.45923072
81Dopaminergic synapse_Homo sapiens_hsa047280.44651052
82Taste transduction_Homo sapiens_hsa047420.44466769
83Cholinergic synapse_Homo sapiens_hsa047250.44019420
84Salivary secretion_Homo sapiens_hsa049700.43093126
85Ras signaling pathway_Homo sapiens_hsa040140.42975577
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42537201
87Viral myocarditis_Homo sapiens_hsa054160.41735257
88Systemic lupus erythematosus_Homo sapiens_hsa053220.41433493
89Amoebiasis_Homo sapiens_hsa051460.40941116
90Tuberculosis_Homo sapiens_hsa051520.40647875
91Sulfur metabolism_Homo sapiens_hsa009200.40471349
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37924572
93Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37561528
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36551471
95Renin-angiotensin system_Homo sapiens_hsa046140.36540930
96MAPK signaling pathway_Homo sapiens_hsa040100.36493867
97Steroid hormone biosynthesis_Homo sapiens_hsa001400.35324666
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.34726470
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.34505259
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34462819

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